Centre de recherche du

Centre hospitalier de l’Université de Montréal (CRCHUM)

A hospital-based research centre oriented towards discovery, therapeutic innovation,

non-invasive exploration of human beings and transfers to patients and populations

Mission

• To improve the health of adults through a continuum of high-quality academic research.

• To provide a training environment that ensures renewal and a commitment to excellence.

Vision

• The CRCHUM is committed to excellence in the development of new knowledge. In keeping with the mission of the hospital, the CRCHUM improves the health of adults through an understanding of etiological and pathogenic mechanisms, the development, implementation and evaluation of new preventive, diagnostic and therapeutic strategies, and health promotion.

• The CRCHUM seeks to foster cross-disciplinary exchanges and to harmonize laboratory research collaborations for the benefit of patients and the population.

Main Partners

Université de Montréal : • Canada’s second-ranked university for income by researcher• Largest faculty of medicine in Canada – encompasses all disciplines• 4th largest faculty of medicine in North America

CHUM :• Quebec's largest teaching hospital• More than 500,000 patient visits annually• Heads up Quebec's largest integrated health network

CRCHUM

International network of partnerships and alliances with the academic, industrial and public sectors

Major Strengths

• Cancer• Infection, Immunity, Inflammation • Cardiometabolic diseases• Musculoskeletal diseases• Neuroscience• Public Health

• February 2008– The CRCHUM’s strengths and vision rated as “exceptional” by

an external review committee of the Fonds de Recherche en Santé du Québec

• Unique capacities in clinical research– Phase I/IIa/IIb trials– Phase III/IV trials

• Optimal integration of basic, clinical, epidemiological and evaluative research

• Unique integration of public health research

• Highly cross-disciplinary and multi-sector environment– Enhanced recruitment and training potential– Magnet for partnerships with industry

• Benefits for the population– Direct impact on health policy, care delivery and services in Quebec, Canada and

abroad (developing countries)– Knowledge and technology transfers to users – population, public sector, private

sector

Major Strengths

Evolution of research income ($M CDN)

Year Peer-reviewed Industry Other Total

1997-98 14.8 8.9 2.2 25.9

1998-99 14.9 11.1 2.5 28.6

1999-00 16.2 9.2 3.9 29.3

2000-01 18.5 9.8 6.2 34.5

2001-02 20.8 10.5 8.5 39.8

2002-03 23.7 11.1 11.3 46.1

2003-04 24.5 11.2 9.3 45.0

2004-05 24.9 9.4 12.2 46.6

2005-06 32.3 10.9 11.7 54.9

2006-07 26.7 9.5 13.8 50.0

2007-08 25.6 10.1 12.4 48.1

2008-09 27.9 12.1 14.0 54.0

1,300 people on six sites 286 clinician researchers (MD & MD/PhD) 101 researchers PhD 6 engineers PhD 356 students

- 118 MSc - 137 PhD - 101 Post docs et Fellows

445 professionals, technicians, office personnel 96 research coordinators

Human Resources

Research Themes

• Cancer– Breast cancer– Ovarian cancer– Prostate cancer

• Cardio-metabolic diseases• Infection, Immunity, Inflammation • Neuroscience• Musculo-skeletal diseases • Public health

Research Themes

• Cancer• Cardio-metabolic diseases

– Diabetes – Cardiovascular diseases – stroke, hypertension,

embolisations, cardiac regeneration…– Cystic fibrosis

• Infection, Immunity, Inflammation • Neuroscience• Musculo-skeletal diseases • Public health

Axes de recherche

• Cancer• Cardio-metabolic diseases• Infection, Immunity, Inflammation

– HIV/AIDS– Hepatitis B & C– Transplantation– Burns

• Neuroscience• Musculo-skeletal diseases • Public health

Axes de recherche

• Cancer• Cardio-metabolic diseases• Infection, Immunity, Inflammation• Neuroscience

– Degenerative genetic diseases : Lou Gehrig’s disease, Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, epilepsy, ataxias, Cushing's disease, muscular dystrophy, encephalopathies, dystonia, Tourette syndrome,…

• Musculo-skeletal diseases • Public health

Axes de recherche

• Cancer• Cardio-metabolic diseases• Infection, Immunity, Inflammation• Neuroscience• Musculo-skeletal diseases

– Arthrosis– Arthritis et rheumatoid arthritis – Osteoarthritis– Biomedical engineering : scoliosis, joint reconstruction

and treatment• Public health

Axes de recherche

• Cancer• Cardio-metabolic diseases• Infection, Immunity, Inflammation• Neuroscience• Musculo-skeletal diseases• Public health

– Risks to health– Global health– Health care system and services

Research Themes

Public health• Three themes:

– Risks to health – ex: modifiable causes of cancer and HIV/AIDS, potential links between behaviour or the environment and a given disease.

– Global health – action-research in developing countries – health care equity, maternal mortality, chronic diseases and access to health care, consultancy service for health infrastructure projects.

– Health care system and services – health care system as a determinant of health, impact of modes of service organization on clinical practices, service quality and access to front-line services.

• Integration of researchers from regional health boards and the Institut national de santé publique du Québec

• Ensures the link between basic and clinical research with regard to the behavioural and environmental (social and physical) bases of disease development.