GreatBritain

Germany

France

Czech Republic

Austria

Switzerland

1

8

2

3

4

567

9

Netherlands

1. Hahn-Schickard CoordinatorMicrofluidic design, simulation, and integration; disc and test cartridge manufacturing

2. ait austrian institute of technology GmbHSaliva sampling strategy, nucleic acid assay development

3. University of Zurich Center of Dental Medicine, Clinic for Preventive Dentistry, Periodontology and Cariology, clinical validation / Section of Oral Microbiology and Immunology, assay development for oral infections

4. Erasmus University Medical Centre rotterdamLaboratory testing, clinical validation, future-proofing, development of a central server for data processing

5. aSKion GmbHDevelopment and manufacturing of LabDisk reader

6. MagnaMedics diagnostics.B.V.Protocols for samples and isolation of nucleic acids, implementation of quantum dots as optical detection nanoparticles

7. ClinicaGeno LtdSoftware algorithms for analysis and interpretation, user interface, data storage

8. BioVendor Laboratorni MedicinaAntibody production, immunoassays, manufacturing of PCR kits, commercialisation

9. Sparks & CoCommunication and dissemination

diaGoraS MiLEStonES 2015-2019

diaGnoStiC worKfLow

June 2015: DIAGORAS project starts

Summer 2016: Ethical approvals

completed

Early 2017: Biological assays and discs

ready as components

End 2017: System integration of

components completed into first prototype

Mid 2018: Analytical validation

in laboratory conditions completed & start of clinical

validation

June 2019: End of the project with clinically validated and

quality control-approved platform

Oral

Respiratory

Saliva

Swab Reagents, DNA/RNA,

protein

LabDisk cartridge

LabDisk reader

Software algorithm

Diagnosis and treatment

Infection Sampling BiossaysAnalysis all-in-one

Readout and detection

Data interpretation

Health outcome;clinical decision

Chair/bedside Diagnosis of Oral and Respiratory Tract Infections, and Identification of Antibiotic Resistances for Personalised Monitoring and Treatment

Global healthcare systems are struggling with the enormous burden of morbidity/mortality associated with infectious diseases, as well as the incessant rise of antimicrobial resistance. To adequately address this problem, there is an urgent need for rapid and accurate point-of-care infectious disease diagnostics.

With funding from the European Union’s Horizon 2020 Programme and the collaboration of 9 organisations from 7 countries, the DIAGO-RAS project utilises research and innovation technologies from the lab to the market in order to address major health concerns: oral and respiratory infections, with associated antibiotic resistance.

The DIAGORAS project will develop a point-of-care microbiological diagnostic platform for use in general practitioner offices, dentist practices and hospital emergency rooms.

the diaGoraS platform will:

• Improve patient management through accurate differentiation between bacterial and viral infections with similar clinical symptoms

• Prevent antibiotic overuse based on antimicrobial resistance screening for targeted therapy

• Increase accessibility by allowing more widespread of epidemiological data

• Early diagnosis and determination of disease level via quantitative bacterial DNA assays and host response protein biomarker detection

• Personalised monitoring for status control during the entire period of treatment

infECtioUS diSEaSES and antiBiotiC rESiStanCE arE GLoBaL iSSUES

Hahn-Schickard © All rights reserved

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant

agreement No 633780.

9 institutions (Including SMEs, universities, research and medical centres)

4 yEarS (2015-2019)

5.6 million €(4.7 M€ from EU with an additional 0.9 M€

contribution from Switzerland)

want to know more?

@diagorasEU

www.diagoras.eu