BIOGRAPHICAL SKETCH

Name: Happi T. Christian Position/Title: Professor & Director, World Bank

funded African Center of Excellence for Genomics of Infectious Diseases (ACEGID)

eRA Commons Username: CTHAPPI Current Working Addresses:

1. Department of Biological Sciences, College of Natural Sciences, Redeemers’ University, Ede, Osun Sate, Nigeria.

2. Office of the Director, African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University, Ede, Osun State, Nigeria.

3. Office of the Director, Directorate of Research, Innovations and Partnerships (DRIPs), Redeemer’s University, Ede, Osun State, Nigeria.

Current Employer (s): Redeemers’ University, Ede, Osun State, Nigeria.

Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

YEAR(s) FIELD OF STUDY

Harvard University, School of Public Health, Boston, MA, USA

Postdoctoral Fellow 2000-2003 Molecular Biology

University of Ibadan, Nigeria

PhD

2000

Molecular Parasitology

University of Ibadan, Nigeria

M.Sc

1995

Molecular Parasitology

University of Yaounde, Cameroon

B.Sc (Hons)

1992

Biochemistry

A. Positions and employments

2017- Director, Directorate of Research, Innovation and Partnerships, Redeemer’s University, Ede, Osun State, Nigeria.

2013-2018- Visiting Professor, Harvard University, Department of Organismic and Evolutionary Biology, Cambridge, Massachusetts, USA.

2012- 2016: Dean, College of Postgraduate Studies, Redeemer’s University, Ede, Osun State, Nigeria.

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2012- Present: Senior Associate Member, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

2011- Present: Professor of Molecular Biology and Genomics, Department of Biological Sciences, College

of Natural Sciences, Redeemers’ University, Ede, Osun State, Nigeria. 2011-Present: Fellow, Exxon-Mobil Corp, USA, Malaria Leadership Programme, Harvard Malaria Initiative,

Harvard University, Boston, MA, USA. 2010-2012: Consultant and Technical Expert, International Atomic Energy Agency, AFRA Programme. 2009-2012: Honorary Senior Research Fellow, Division of Infections and Immunity, School of Medicine,

University of Glasgow, Scotland, United Kingdom. 2009-Present: Visiting Professor, Harvard University, Department of Immunology and Infectious Diseases,

Harvard School of Public Health, Boston, MA, USA. 2007- present: Adjunct Faculty, Department of Pharmacology and Therapeutics, College of Medicine,

University of Ibadan, Ibadan, Nigeria. 2006- Visiting Faculty, Department of Preventive Medicine, Faculty of Medicine, Federal University

of Rio de Janeiro, Brazil. 2004-2009: Research Fellow, Department of Immunology and Infectious Diseases, Harvard School of

Public Health, Harvard University, Boston, MA, USA. 2003-2012: Committee member and Temporary advisor, WHO/TDR Transfection Technology Network. 2003-2012: Principal Investigator, Malaria Research Laboratories, IMRAT, College of Medicine, University

of Ibadan, Nigeria. 2002-2013: Visiting Research Scientist, Division of Experimental Therapeutics, Walter Reed Army Institute

of Research, Silver Springs, MD, USA. 2002-2009: Nigerian National Coordinator, International Atomic Energy Agency (IAEA) RAF/0625/UNDP

project Monitoring Drug Resistance to Malaria and Tuberculosis. 2001 to 2005: WHO/TDR Molecular Biologist Consultant, MIM/TDR Antimalarial Drugs Resistance Network

in Africa. 2000 to 2003: Post-doctoral Research Fellow, Department of Immunology and Infectious Diseases, Harvard

School of Public Health, Harvard University, Boston, MA, USA. 1997-2000: Junior Research Fellow, Malaria Research Laboratories, PIMRAT, College of Medicine,

University of Ibadan, Nigeria.

B. Honors and Awards. 2016- National Universities Commission Award for the Best Nigerian Academic Researcher in the

field of Life Sciences and Medicine. 2015- Vice-Chancellor’s Hero Award, Redeemer’s University 10th Anniversary. 2015- Best Researcher Award, Redeemer’s University 10th Anniversary. 2014-2018 World Bank Grant Award to establish the African Centre of Excellence of Genomics of

Infectious Diseases (ACEGID).

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2013-2017 USA, NIH Grant Award to Characterize Fevers of Unknown Origin through Microbial Metagenomics.

2011-2016 Exxon-Mobil Corp. USA, Harvard University Malaria Leadership Fellowship Award (USA).

2011- 2011, Merle A. Sande Health Leadership Award (Accordia Foundation, USA).

2010-2015 USA, NIAID Grant Award to study Host Genetic Factors in Resistance to Lassa fever. 2010-2014 USA, NIH Grant Award to study Host Pathogen Evolution in Lassa fever. 2010- Scholarship to attend the Second Annual Course on Point-of-Care Diagnostics for Global

Health, University of Washington Seattle (USA).

2010- Boroughs Wellcome and Bill & Melinda Gates Awards (USA). 2009-2014 USA, NIAID Grant to study the Roles of Protective or Pathogenic B cell Epitopes in Human

Lassa Fever. 2009-2014 Wellcome Trust Research Grant Award (UK).

2009- 2011 European Union-Developing Countries Clinical Trials Partnership (EDCTP) Senior Research

Fellowship Award (The Hague, Netherlands). 2008- Chair, Scientific Advisory Committee Africa Health Research Organization (AHRO) (Ghana). 2007-2011 NIH/Fogarty International Centre Research Collaboration Grant Award. (NIH, USA).

2007- Turner Biosciences Research Grant Award (USA).

2005-2008 WHO/TDR Plasmodium falciparum Pathogenesis and Applied Genomics Research Grant

Award (World Bank/ UNICEF/WHO/TDR).

2005-2006 International Society of Infectious Diseases (ISID) Research Grant Award (USA). 2004-2005 Research Award for Microarrays Analysis of Plasmodium falciparum Genome (MR4, USA).

2004 Chair, Molecular Parasitology session, 50th Annual Meeting and Anniversary of the American

Society of Tropical Medicine and Hygiene, Philadelphia, Pennsylvania, USA. 2003-2006 NIH/Fogarty International Center Research Collaboration Grant Award (NIH, USA).

2000-2003 WHO/TDR Postdoctoral Research Fellowship Award (World Bank/UNICEF/WHO/TDR). 1999 Award of the Best Postgraduate Student, University of Ibadan (Nigeria). 1998 Wellcome Trust Travel Award to attend the 1st Gordon Conference on Malaria (Oxford, UK).

1995 Award of the Best International Student, University of Ibadan (Nigeria). 1994-1997 Organization of African Unity (OAU), PhD Scholarship Award.

1988-1993 Cameroon Government Scholarship.

C. Membership of Learned Society.

1. Member Advisory Board, 2016 World Innovation Summit for Health Conference, Doha, Qatar 2. Member, International Scientific Organizing Committee, 9th Pan-African MIM Conference (Senegal, 2017)

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3. Member, Scientific Advisory Committee, Keystone Symposia Africa (Keystone Symposia USA) 4. Member Scientific Advisory Board, NIH funded BRAINS Project, Harvard University-University of Lagos, Nigeria 5. Member Scientific Advisory Board, NIH funded STAMINA Project, Harvard University-University of Jos, Nigeria 6. Member, Wellcome Trust-CIDRAP Ebola Vaccine Team B (2014)

7.Board Member, African Health Research Organization (AHRO), Ghana

8. Member, USA National Institutes of Health (NIH) International Centers of Infectious Diseases Research (ICIDR) Review Committee. (2014)

9. Member, USA National Institutes of Health (NIH) Centers of Excellence for Translational Research (CETR) Review Committee and Special Emphasis Panel. (2013). 10. Senior Associate Member, Broad Institute of Harvard and MIT 11. Member Steering Committee H3 Africa Consortium 12. Member, International Scientific Advisory Board, Accordia Global Health Foundation, Washington, DC, USA. (2011-2014).

13. Member of the African Academy of Science. (2004-Date)

14. International Scientific Committee Member, 4th Pan-African MIM conference (Cameroon). 15. Member of the Royal Society of Tropical Medicine, UK. (2001-date) 16. Member of the American Society of Tropical Medicine and Hygiene, USA. (2000-date)

17. Foundation member, Worldwide Antimalarial drugs Resistance Network [WWARN] (USA).

D. Peer-Review. Member of Editorial Board/ Reviewer for Internationally Peer-reviewed Journals including:

1. Acta Tropica (Sweden); 2. African Journal of Medicine and Medical Sciences (Nigeria); 3. American Journal of Tropical Medicine and Hygiene (USA); 4. Annals of Tropical Medicine and Parasitology (UK); 5. Antimicrobial Agents and Chemotherapy (USA); 6. BMC Infectious Diseases (UK); 7. Drug Design, Development and Therapy (USA); 8. Emerging Infectious Diseases (USA); 9. Experimental Parasitology (USA); 10. Genome Biology (UK) 11. Infectious Disease News (USA); 12. International Journal of Parasitology (Australia); 13. Journal of Bacteriology and Parasitology (USA); 14. Journal of Infectious Diseases (USA); 15. Journal of Postgraduate Medicine (Canada); 16. Journal of Travel Medicine (USA); 17. Lancet Infectious Diseases (UK); 18. Malaria Journal (UK);

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19. Parasitology Research (Germany); 20. Parasitology International (Japan) 21. Pharmacogenetics and Pharmacogenomics (Australia); 22. PLOS Genetics (USA) 23. PLOS Infectious Diseases (USA); 24. PLOS Medicine (USA); 25. PLOS One (USA); 26. Science (USA) 27. The Open Tropical Medicine Journal (USA); 28. The Medical Letter (USA); 29. Transactions of the Royal Society of Tropical Medicine and Hygiene (UK); 30. Tropical Medicine and International Health (UK). E. Selected Peer-reviewed Publications (Selected out of >150 in Reverse Chronological Order).

1. Gytis Dudas, Luiz Max Carvalho, Trevor Bedford, Andrew J. Tatem, Guy Baele, Nuno R. Faria, Daniel J. Park, Jason T. Ladner, Armando Arias, Danny Asogun, Filip Bielejec, Sarah L. Caddy, Matthew Cotton, Jonathan D’Ambrozio, Simon Dellicour, Antonino Di Caro, Joseph W. Diclaro II, Sophie Duraffour, Michael J. Elmore, Lawrence S. Fakoli III, Ousmane Faye, Merle L. Gilbert, Sahr M. Gevao, Stephen Gire, Adrianne Gladden-Young, Andreas Gnirke, Augustine Goba, Donald S. Grant, Bart L. Haagmans, Julian A. Hiscox, Umaru Jah, Brima Kargbo, Jeffrey R. Kugelman, Di Liu, Jia Lu, Christine M. Malboeuf, Suzanne Mate, David A. Matthews, Christian B. Matranga, Luke W. Meredith, James Qu, Joshua Quick, Suzan D. Pas, My VT Phan, Georgios Pollakis Chantal B. Reusken, Mariano Sanchez-Lockhart, Stephen F. Schaffner, John S. Schieffelin, Rachel S. Sealfon, Etienne Simon-Loriere, Saskia L. Smits, Kilian Stoecker, Lucy Thorne, Ekaete Alice Tobin, Mohamed A. Vandi, Simon J. Watson, Kendra West, Shannon Whitmer, Michael R. Wiley, Sarah M. Winnicki, Shirlee Wohl, Roman W olfel, Nathan L.Yozwiak, Kristian G. Andersen, Sylvia O. Blyden, Fatorma Bolay, Miles W. Carroll, Bernice Dahn, Boubacar Diallo, Pierre Formenty, Christophe Fraser, George F. Gao, Robert F. Garry, Ian Goodfellow, Stephan Gunther, Christian T. Happi, Edward C. Holmes, Brima Kargbo, Sakoba Keıta, Paul Kellam, Marion P. G. Koopmans, Jens H. Kuhn, Nicholas J. Loman, N’Faly Magassouba, Dhamari Naidoo ,Stuart T. Nichol, Tolbert Nyenswah, Gustavo Palacios, Oliver G. Pybus, Pardis C. Sabeti, Amadou Sall, Ute Stroher, Isatta Wurie, Marc A. Suchard, Philippe Lemey & Andrew Rambaut. (2017). Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature (In Press). 2. Sowunmi A, Akano K, Ayede AI, Adewoye EO, Ntadom G, Fatunmbi B, Gbotosho GO, Folarin OA, Happi CT. (2017). Early rising asexual parasitaemia in Nigerian children following a first dose of artemisinin-based combination treatments of falciparum malaria. BMC Infect Dis. 17(1):110. doi: 10.1186/s12879-016-2173-z. 3. Akintunde Sowunmi, Kazeem Akano, Godwin Ntadom, Adejumoke I. Ayede, Folasade O. Ibironke, Temitope Aderoyeje, Elsie O. Adewoye, Bayo Fatunmbi, Stephen Oguche, Henrietta U. Okafor, Ismaila Watila, Martin Meremikwu, Philip Agomo, William Ogala, Chimere Agomo, Onikepe A. Folarin, Grace O. Gbotosho, Christian Happi. (2016), Therapeutic efficacy and effects of artemisinin-based combination treatments on uncomplicated Plasmodium falciparum-associated anaemia in Nigerian children during seven years of adoption as first-line treatments. Infectious Disease of Poverty. 6(1):36. doi: 10.1186/s40249-016-0217-7. 4. Olumuyiwa B. Salu, Ayorinde B. James, Bamidele O. Oke, Mercy R. Orenolu, Roosevelt A. Anyanwu, Maryam A. Abdullah, Christian Happi, Jide Idris, Ismail A. Abdus-Salam, Abdul-Salam Nasidi, Folashade T. Ogunsola, Oyewale Tomori, Sunday AOmilabu. (2016). Biosafety level-2 laboratory diagnosis of Zaire Ebola virus disease imported from Liberia to Nigeria. Afr J Lab Med. 2016;5(1), a468.doi.org/10.4102/ajlm.v5i1.468

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5. Olumide O Adenmosun, Christian Happi, Oluwaseyi Ogunmodede, Yemi Adesokan and Obidele Samuel Opeyemi. (2016). Preventing resurgence of Ebola Resurgence from Zoonotic Routes: A Random Assessment of Bat populations in Osun State, Nigeria. J Prev Inf Cntrl. 2016, 2:2.15. DOI: 10.21767/2471-9668.100024 6. Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF; Viral Hemorrhagic Fever Consortium. (2016). An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. J Infect Dis. 214(suppl 3):S110-S121. 7. Folarin OA, Ehichioya D, Schaffner SF, Winnicki SM, Wohl S, Eromon P, West KL, Gladden-Young A, Oyejide NE, Matranga CB, Deme AB, James A, Tomkins-Tinch C, Onyewurunwa K, Ladner JT, Palacios G, Nosamiefan I, Andersen KG, Omilabu S, Park DJ, Yozwiak NL, Nasidi A, Garry RF, Tomori O, Sabeti PC, Happi CT. (2016). Ebola Virus Epidemiolpgy and Evolution in Nigeria. J Infect Dis. 214(suppl 3):S102-S109 8. Yozwiak NL, Happi CT, Grant DS, Schieffelin JS, Garry RF, Sabeti PC, Andersen KG. (2016). Roots, Not Parachutes: Research Collaborations Combat Outbreaks. Cell. 2016 Jun 30;166(1):5-8. doi: 10.1016/j.cell.2016.06.029. 9. Robinson JE, Hastie KM, Cross RW, Yenni RE, Elliott DH, Rouelle JA, Kannadka CB, Smira AA, Garry CE, Bradley BT, Yu H, Shaffer JG, Boisen ML, Hartnett JN, Zandonatti MA, Rowland MM, Heinrich ML, Martínez-Sobrido L, Cheng B, de la Torre JC, Andersen KG, Goba A, Momoh M, Fullah M, Gbakie M, Kanneh L, Koroma VJ, Fonnie R, Jalloh SC, Kargbo B, Vandi MA, Gbetuwa M, Ikponmwosa O, Asogun DA, Okokhere PO, Folarin OA, Schieffelin JS, Pitts KR, Geisbert JB, Kulakoski PC, Wilson RB, Happi CT, Sabeti PC, Gevao SM, Khan SH, Grant DS, Geisbert TW, Saphire EO, Branco LM, Garry RF. (2016). Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. Nat Commun.7:11544. doi: 10.1038/ncomms11544. 10. G. David Poznik, Yali Xue, Fernando L. Mendez, Thomas F. Willems, Andrea Massaia, Melissa A. Wilson Sayres, Qasim Ayub, Shane A. McCarthy, Apurva Narechania, Seva Kashin, Yuan Chen, Ruby Banerjee, Juan L. Rodriguez-Flores, Maria Cerezo, Haojing Shao, Melissa Gymrek, Ankit Malhotra, Sandra Louzada, Rob Desalle, Graham R. S. Ritchie, Eliza Cerveira, Tomas W. Fitzgerald, Erik Garrison, Anthony Marcketta, David Mittelman, Mallory Romanovitch, Chengsheng Zhang, Xiangqun Zheng-Bradley, Goncalo R. Abecasis, Steven A. McCarroll, Paul Flicek, Peter A. Underhill, Lachlan Coi, Daniel R. Zerbino, Fengtang Yang, Charles Lee, Laura Clarke, Adam Auton, Yaniv Erlich, Robert E. Handsaker, The 1000 Genomes Project Consortium, Carlos D. Bustamante, and Chris Tyler-Smith. (2016). Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nature Genetics. 48(6): 593–599. doi:10.1038/ng.3559. 11. Osterholm M, Moore K, Ostrowsky J, Kimball-Baker K, Farrar J; Wellcome Trust-CIDRAP Ebola Vaccine Team B. (2016). The Ebola Vaccine Team B: a model for promoting the rapid development of medical countermeasures for emerging infectious disease threats. Lancet Infect Dis. 16(1):e1-9. doi: 10.1016/S1473-3099(15)00416-8. 12. Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A, Huddleston J, Zhang Y, Ye K, Jun G, Hsi-Yang Fritz M, Konkel MK, Malhotra A, Stütz AM, Shi X, Paolo Casale F, Chen J, Hormozdiari F, Dayama G, Chen K, Malig M, Chaisson MJ, Walter K, Meiers S, Kashin S, Garrison E, Auton A, Lam HY, Jasmine Mu X, Alkan C, Antaki D, Bae T, Cerveira E, Chines P, Chong Z, Clarke L, Dal E, Ding L, Emery S, Fan X, Gujral M, Kahveci F, Kidd JM, Kong Y, Lameijer EW, McCarthy S, Flicek P, Gibbs RA, Marth G, Mason CE, Menelaou A, Muzny DM, Nelson BJ, Noor A, Parrish NF, Pendleton M, Quitadamo A, Raeder B, Schadt EE, Romanovitch M, Schlattl A, Sebra R, Shabalin AA, Untergasser A, Walker JA, Wang M, Yu F, Zhang C, Zhang J, Zheng-

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Bradley X, Zhou W, Zichner T, Sebat J, Batzer MA, McCarroll SA; 1000 Genomes Project Consortium, Mills RE, Gerstein MB, Bashir A, Stegle O, Devine SE, Lee C, Eichler EE, Korbel JO. An integrated map of structural variation in 2,504 human genomes. (2015). Nature. 526(7571):75-81. doi: 10.1038/nature15394. 13. 1000 Genomes Project Consortium, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, Abecasis GR. (2015). A Golobal reference for human genetic variations. Nature. 526(7571):68-74. doi: 10.1038/nature15393. 14. Kristian Graugaard Andersen, B. Jesse Shapiro, Christian B Matranga, Rachel Sealfon, Aaron E Lin, Lina M Moses, Onikepe A Folarin, Augustine Goba, Ikponmwonsa Odia, Philomena E Ehiane, Mambu Momoh, Eleina M England, Sarah Winnicki, Luis M Branco, Stephen K Gire, Eric Phelan, Ridhi Tariyal, Ryan Tewhey, Omowunmi Omoniwa, Mohammed Fullah, Richard Fonnie, Mbalu Fonnie, Lansana Kanneh, Simbirie Jalloh, Michael Gbakie, Sidiki Saffa, Kandeh Karbo, Adrianne D Gladden, James Qu, Matthew Stremlau, Mahan Nekoui, Hilary K Finucane, Shervin Tabrizi, Joseph J Vitti, Bruce Birren, Michael Fitzgerald, Caryn McCowan, Andrea Ireland, Aaron M Berlin, James Bochicchio, Barbara Tazon-Vega, Niall J Lennon, Elizabeth M Ryan, Zach Bjornson, Danny A Milner JR, Amanda K Lukens, Nisha Broodie, Megan Rowland, Megan Heinrich, Marjan Akdag, John S Schieffelin, Danielle Levy, Henry Akpan, Daniel G Bausch, Kathleen Rubins, Joseph B McCormick, Eric S Landers, Stephan Gunther, Lisa Hensley, Sylvanus Okogbenin, Stephen F Schaffner, Peter O Okokhere, S. Humarr Khan, Donald S Grant, George O Akpede, Danny A Asogun, Andreas Gnirke, Joshua Levin, Christian T. Happi, Robert F Garry, Pardis C Sabeti. (2015). Genome-sequencing from clinical and field samples uncovers ancient origins and intra-host evolution of Lassa virus. Cell. 162(4): 738-750. doi: 10.1016/j.cell.2015.07.20. 15. Park DJ, Dudas G, Wohl S, Goba A, Whitmer SLM, Andersen KG, Sealfon RS, Ladner JT, Kugelman JR, Matranga CB, Winnicki SM, Qu J, Gire SK, Gladden-Young A, Jalloh S, Nosamiefan D, Yozwiak NL, Moses L, Jiang P-P, Lin AE, Schaffner SF, Bird B, Towner J, Mamoh M, Gbakie M, Kanneh L, Kargbo D, Massally JLB, Kamara FK, Konuwa E, Sellu J, Jalloh AA, Mustapha I, Foday M, Yillah M, Erickson BR, Sealy T, Blau D, Paddock C, Brault A, Amman B, Basile J, Bearden S, Belser J, Bergeron E, Campbell S, Chakrabarti A, Dodd K, Flint M, Gibbons A, Goodman C, Klena J, Mc- Mullan L, Morgan L, Russell B, Salzer J, Sanchez A, WAng D, Jungreis I, Tomkins-Tinch C, Kislyuk A, Lin MF, Chapman S, MacInnis B, Matthews A, Bochicchio J, Hensley LE, Kuhn JH, Nusbaum C, Scheiffelin JS, Birren BW, Forget M, Nichol ST, Palacios GF, Ndiaye D, Happi C, Gevao SM, Vandi MA, Kargbo B, Holmes EC, Bedford T, Gnirke A, Stroeher U, Rambaut A, Garry RF, Sabeti PC. (2015). Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone. Cell. 161(7): 1516-26. doi: 10.1016/j.cell.2015.06.007. 16. Jessica N Hartnett, Matthew L Boisen1, Darin Oottamasathien, Abigail B Jones, Molly M Millett, Diana S Nelson, Ivana J Muncy, Augustine Goba, Mambu Momoh, Mohammed Fullah, Chad E Mire, Joan B Geisbert, Thomas W Geisbert, Debra L Holto, Julie A Rouelle, Chandrika B Kannadka, Ashley A Reyna, Lina M Moses, S Humarr Khan, Sahr M Gevao, Donald S Grant, James E Robinson, Christian Happi, Kelly R Pitts, Robert F Garry, Luis M Branco & the Viral Hemorrhagic Fever Consortium. (2015). Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever. Future Virol. (2015) 10(5), 559–584. 17. Matthew H. Stremlau, Kristian G. Andersen, Onikepe A. Folarin, Jessica N. Grove, Ikponmwonsa Odia, Philomena E. Ehiane, Omowunmi Omoniwa, Omigie Omoregie, Pan-Pan Jiang, Nathan L. Yozwiak, Christian B. Matranga, Xiao Yang, Stephen K. Gire, Sarah Winnicki, Ridhi Tariyal, Stephen F. Schaffner, Peter O. Okokhere, Sylvanus Okogbenin, George O. Akpede, Danny A. Asogun, Dennis E. Agbonlahor, Peter J. Walker, Robert B. Tesh, Joshua Z. Levin, Robert F.Garry, Pardis C. Sabeti, and Christian T. Happi. (2015). Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa. PLoS Negl Trop Dis 9(3): e0003631. doi:10.1371/journal.pntd.0003631. 18. Falajiki FY, Akinola O, Abiodun OO, Happi CT, Sowunmi A and Gbotosho GO. (2015). Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria. Parasitology. 4: 1-6. 19. Jens H. Kuhn, Kristian G. Andersen, Sylvain BAIZE, Yīmíng Bào, Sina Bavari, Nicolas Berthet, Olga Blinkova, J. Rodney Brister, Anna N. Clawson, Joseph Fair, Martin Gabriel, Robert F. Garry, Stephen K. Gire, Augustine Goba, Jean-Paul Gonzalez, Stephan Günther, Christian T. Happi, Peter B. Jahrling, Jimmy

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110. Adedeji, A.A., Fehintola, F.A., Fateye, B.A., Happi, T.C., Amoo, A.O.J., Gbotosho, G.O. and A. Sowunmi. (2005). Plasmodium falciparum malaria during high and low transmission seasons in Nigerian children: gametocyte carriage and response to oral chloroquine. Journal of Tropical Paediatrics. 51(5):288-94. 111. Sowunmi A, Fateye BA, Adedeji AA, Fehintola FA, Gbotosho GO, Happi TC, Tambo E and AMJ Oduola. (2005). Predictors of failure of treatment with chloroquine in children with acute, uncomplicated, Plasmodium falciparum malaria, in an area with high increasing incidences of chloroquine resistance. Annals of Tropical Medicine & Parasitology. 99 (6):535-544. 112. Sowunmi A, Fateye BA, Adedeji AA, Fehintola FA, Bamgboye EA, Babalola CP, Happi TC and Gbotosho GO. (2005). Effects of antifolates – co-trimoxazole and pyrimethamine-sulfadoxine on gametocytes in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria. Mem Inst Oswaldo Cruz. 100 (4): 451-455. 113. Happi CT, Gbotosho GO, Folarin OA, Akinboye DO, Yusuf BO, Ebong, OO, Sowunmi A, Kyle DE, Milhous W, Wirth DF and AMJ Oduola. (2005). Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria. Acta Tropica. 95 (3):183-193. 114. Sowunmi A, Fateye BA, Adedeji AA, Fehintola FA, Gbotosho GO, Happi TC, Oduola AM. (2005). Predictors of the failure of treatment with chloroquine plus chlorpheniramine, in children with acute, uncomplicated, Plasmodium falciparum malaria. Annals of Tropical Medicine & Parasitology. 99(4):331-8. 115. Sarah J. Bates, Peter A. Winstanley, William M. Watkins, Ali Alloueche, Juma Bwika, Christian T. Happi, Peter G. Kremsner, James G. Kublin, Zul Premji, Carol Hopkins Sibley. (2004). Rare, highly pyrimethamine-resistant alleles of Plasmodium falciparum dihydrofolate reductase from five African sites. The Journal of Infectious Diseases. 190(10):1783-92. 116. Sowunmi, A., Fateye, B.A., Adedeji, A.A., Fehintola, F.A. & Happi, T.C. (2004). Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children. Parasitology. 129:255-62. 117. Sowunmi, A., Happi, T.C. & Oduola, A.M.J. (2004). Reversal of chloroquine resistance in Plasmodium falciparum. Journal of Applied Therapeutic Research. 5 (1): 3-11. 118. Oduola, O.O., Happi T.C., Gbotosho, G.O., Ogundahunsi, O. A. T., Falade, C. O., Akinboye, D.O., Sowunmi, A., and A.M.J.Oduola. (2004). Plasmodium berghei: efficacy and safety of combinations of chloroquine and promethazine in chloroquine resistant infections in gravid mice. African Journal of Medicine and Medical Sciences. 33. 77-81. 119. Happi, C.T., Gbotosho, G.O., Sowunmi, A., Falade, C.O., Akinboye, D.O. Oladepo O., and AMJ Oduola (2004). Malaria diagnosis: False negative parasighttm-f tests in falciparum malaria patients in Nigeria. African Journal of Medicine and Medical Sciences. 33. 15-18. 120. Sowunmi, A., Fehintola, F.A., Adedeji, A.A., Gbotosho, G.O., Falade, C.O., Tambo, E., Fateye, B.A., Happi, T.C. & Oduola, A.M.J. (2004). Open randomized study of pyrimethamine-sulfadoxine versus pyrimethamine-sulfadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children. Tropical Medicine & International Health. 9 (5): 606–614. 121. Fehintola, F.A., Adedeji, A.A., Tambo, E., Fateye, B.B., Happi, T.C. & Sowunmi, A. (2004). Cotrimoxazole in the treatment of acute uncomplicated falciparum malaria in Nigerian children: a controlled clinical trial. Clinical Drugs Investigation. 24 (3): 149-155. 122. Happi CT, Gbotosho GO, Sowunmi A, Falade CO, Akinboye DO, Gerena L, Kyle DE, Milhous W, Wirth DF and AMJ Oduola (2004). Molecular analysis of recrudescent Plasmodium falciparum malaria infections in children treated with chloroquine in Nigeria. American Journal Tropical Medicine & Hygiene. 70 (1): 20-26. 123. Ajaiyeoba EO, Oladepo O, Fawole OI, Bolaji OM, Akinboye DO, Ogundahunsi OA, Falade CO, Gbotosho GO, Itiola OA, Happi TC, Ebong OO, Ononiwu IM, Osowole OS, Oduola OO, Ashidi JS, Oduola AM. (2003).

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Cultural categorization of febrile illnesses in correlation with herbal remedies used for treatment in Southwestern Nigeria. J Ethnopharmacology. 85 (2-3):179-85. 124. Sowunmi, A., Fateye, B.A., Happi, TC., Gbotosho, G.O. & Odula, A.M.J. (2003). Plasmodium falciparum gametocytaemia in Nigerian children: peripheral immature gametocytaemia as indicator of response to chloroquine treatment and its relationship to molecular determinants of chloroquine resistance. Annals of Tropical Medicine & Parasitology.97 (5): 453-468. 125. Happi CT, Thomas SM, Gbotosho GO, Falade CO, Akinboye DO, Gerena L, Hudson T, Sowunmi A, Kyle DE, Milhous W, Wirth DF, and AMJ Oduola. (2003). Point mutations in the pfcrt and pfmdr1 genes of Plamsodium falciparum and clinical response to chloroquine in malaria patients from Nigeria. Annals of Tropical Medicine & Parasitology.97 (5): 439-451. 126. Sowunmi, A., A. I. Ayede, A. G. Falade, V. N. Ndikum, C. O. Sowunmi, A. A. Adedeji, C. O. Falade, TC. Happi and A. M. Oduola (2001). Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine & Parasitology. 95(6): 549-58. 127. Sowunmi, A., A. A. Adedeji, C. O. Sowunmi, C. O. Falade, A. G. Falade, B. Ohaeri, T. C. Happi and A. M. Oduola (2001). Clinical characteristics and disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine & Parasitology. 95(1): 7-18. 128. Sowunmi, A, Falade, C.O, A.A Adedeji, Happi, T.C., C.O.Sowunmi, and A.B.Ofi, F.A. Okunlawon and A.M.J Oduola (2000). Electrocardiograhic changes during chloroquine and halofantrine treatment in patients of southwest Nigeria. Clinical Drugs Investigation. 20 (4): 229-235. 129. Sowunmi, A., F. A. Fehintola, O. A. Ogundahunsi, A. B. Ofi, T. C. Happi and A. M. Oduola (1999). Comparative cardiac effects of halofantrine and chloroquine plus chlorpheniramine in children with acute uncomplicated falciparum malaria. Transactions of the Royal Society of Tropical Medicine & Hygiene. 93(1): 78-83.

E. Research Support.

Ongoing Support

1. African Center of Excellence for Genomics of Infectious Diseases (ACEGID).

Role: Centre Director: Funding: World Bank. Period: 2014-2018.

This project aims at establishing at Redeemer’s University an African Center of Excellence devoted to the genomics of Infectious diseases. ACEGID has as one of its mandates to use knowledge of genomics to the issue of Infectious diseases in Africa. In addition, ACEGID will develop a critical mass of well-trained African scientists that will use genomics knowledge to address African health problems. ACEGID will also establish in Nigeria the first postgraduate curriculum in Genomics and the first formal postdoctoral training programme in Infectious diseases of Africa.

2. Characterizing Fevers of Unknown Origin through Microbial Metagenomics

Role: Principal Investigator. Funding: NIH (USA) 1U01HG007480 - 01. Period: 2013-2017.

Major efforts in this project will devoted to establish a West African genomics Research (WAGER) Network. Initial members of the WAGER network consist of Institutions in Nigeria, Senegal and Sierra-Leone. Scientific activities around the network will consist of using the microbial metagenomics approach to characterize fever of unknown origin and for pathogen discovery in West Africa.

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3. Development of a novel malaria-screening tool in resource-poor settings using a simple, power-free cell phone device

Role: Co-Principal Investigator. Funding: NIH (USA) 1R21TW009915-01. Period: 2015-2017

Efforts in this project were devoted to use an innovative approach that combines, malaria biology, Magnetic levitation and smart phone technology to develop a simple power free tool for malaria diagnosis in resource poor settings of Africa.

Completed

1. Host and Pathogen Evolution in Lassa Fever. Role: International project Director. Funding: National Institutes of Health (USA). Period: 2010-2015

The project has three specific efforts: 1) Support the field-site in Nigeria where we collect samples of both patients of Lassa virus and their contacts. 2) Sequence virus from patients with Lassa virus to study viral diversity and develop a diagnostic, 3) Genotype both human patients with Lassa virus and healthy contacts to identify genetic factors driving Lassa susceptibility, 4) work on computational methods to detect natural selection in humans and to carry out functional validation of candidate loci.

2. Host Genetic Factors in Resistance to Lassa Hemorrhagic Fever Role: International Project Director. Funding: NIAID (USA). Period: 2010-2015. The goal of this Project is to replicate strong signals of natural selection found in Yorubas at genes critical for infection with Lassa virus (LASV) in four additional West African populations, and to localize and characterize the key functional mutations. Seventy (70) mother-father-child trios from 4 populations with high rates of Lassa Fever (Nigeria, Sierra Leone, Liberia, and Guinea) will be recruited. We will also collect 500-1000 cases of severe Lassa fever (LF) and 1500-2000 controls at the Specialist Teaching Hospital in Irrua, Nigeria, perform Lassa Fever genome wide association study (GWAS) in Nigeria and Sierra Leone, and localize causal variants in candidate regions.

3. Roles of protective or pathogenic B cell epitopes in human Lassa Fever

Role: International Project Director. Funding: NIAID (USA). Period: 2009-2014. The goal of this program is to identify novel B cell epitopes on Lassa virus (LASV) proteins and elucidate novel mechanisms of antibody-mediated protection or pathogenesis in humans Lassa fever (LF).

4. Validation of New Biomarkers for Monitoring Plasmodium falciparum Reduced

susceptibility/Tolerance or Resistance to Artemisinin Derivatives and Partner Drugs in Nigeria.

Role: Principal Investigator. Funding: EDCTP (EU). Period: 2009-2013.

Activities in this project aim at validating new biomarkers of Plasmodium falciparum reduced susceptibility/tolerance/resistance to artemisinin derivatives and lumefantrine in clinical testing centers of Nigeria.

5. Genetic determinants of human susceptibility to Lassa Fever Virus. Role: International Project Director. Funding: Harvard University (USA). Period: 2008- 2013.

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This project has two major objectives. 1) use of the understanding of genetic variation in Lassa virus sequences for development of a rapid and reliable diagnostic for Lassa fever virus and 2) use a genome-wide sequencing approach to identify and validate genetic determinants of human susceptibility to Lassa fever virus.

6. Molecular determinants of P. falciparum resistance to ACTs in Nigeria.

Role: Principal Investigator. Funding: NIH/FIC (USA). Period: 2008-2011.

The major goal of this project is identify new molecular determinants of P. falciparum resistance to artermisinin derivatives and partner drugs used for treatment of acute uncomplicated malaria in Nigeria and other African countries.

7. Molecular determinants of drug response and resistance in P. falciparum of Africa and South-

America. Role: Principal investigator. Funding: WHO/TDR. Period: 07/2005-09/2009.

The goal of this project is to explore the geographic differential expression profiles of P. falciparum genes

in culture adapted isolates from Nigeria and Brazil. 8. Plasmodium Transfection Network: Nigeria Center.

Role: Co-Principal Investigator. Funding: WHO/TDR. Period: 2003-2012 This project aims at using the transfection technology to develop unique animals and human models of malaria parasites for antimalarial drugs screening in vitro and in vivo. This project also aims at building capacity in transfection technology among Young Nigerian scientists.

9. World-wide Plasmodium Genetic Diversity. Role: Co-investigator. Funding: Bill and Melinda Gates Foundation. Period: 2009-2012.

The aim of this project is to study and understand genome diversity in the Plasmodium specie from different endemic areas of the world.

10. Validation of a new fluoremetric method for determining Plasmodium falciparum susceptibility to

antimalarial drugs in vitro in fresh patients’ samples.

Role: Principal Investigator. Funding: TurnerBiosciences, USA. Period: 12/2007-12/2009.

The goal of this project is to use a TBS-380 fluorescence detector to validate SYBR Green as an alternative colorimetric assay for determination of Plasmodium falciparum susceptibility to antimalarial drugs in vitro in Nigeria.

11. Molecular determinants of drug resistant malaria in Nigeria

Role: Principal Investigator. Funding: NIH/Fogarty International Centre. 10/01/2003- 10/11/2007.

The major goal of this project is identify new molecular determinant of drug response in fresh field isolates of P. falciparum from Nigeria.

12. Improving home management of malaria using the combination of artemether-lumefantrine in

southwest Nigeria.

Role: Co-investigator. Funding: WHO/TDR. 04/2005-12/2007.

The main objective of the study is to produce evidence on the feasibility, acceptability and safety of the use of Artemether-lumefantrine in the context of Home Management of Malaria (HMM) in Nigeria.

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13. Antimalarial Drug Resistant Network in Africa: Defining and Monitoring Drug Resistant P. falciparum In Southwest Nigeria.

Role: Co-Principal Investigator. Funding: WHO/MIM/TDR. 04/2002- 10/2006.

The aim of the project was to define the characteristics of P. falciparum resistance to standard antimalarial drugs (chloroquine, sulphadoxine-pyrimethamine, amodiaquine). Clinical outcome of patients were collated with parasitological and pharmacokinetics data in children treated with the first (Cchloroquine) and second line (Sulfadoxine-pyrimethamine) antimalarial drugs in Nigeria.

14. MIM/TDR Antimalaria drug resistant network Analytical and Training Center for pharmacokinetics

Role: Co-principal Investigator. Funding:WHO/MIM/TDR. 04/2002-10/2006.

Efforts in this study were devoted to providing support and the protocols for drug analysis adopted by the MIM/TDR antimalarial drug resistance network. In addition, the project provided training on pharmacokinetic analysis and facilitated transfer of technology to the network sites.

15. A collaborative approach for monitoring the spread of resistant Plasmodium falciparum infections in Nigeria

Role: Principal investigator. Funding: IAEA /UNDP. 01/10/2003-31/06/2006.

The dot-blot technique was used for identification of markers of chloroquine and sulfadoxine pyrimethamine resistance in patients isolates of P. falciparum in Nigeria, through a partnership between the Malaria Research Laboratories (MRL), University of Ibadan, the International atomic energy Agency (IAEA) and WHO-Roll back malaria.

16. Identification of candidate single nucleotide polymorphisms (SNPs) in Plasmodium falciparum isolates showing false negative results using the parasight®-f dipstick.

Role: Co-Principal Investigator. Funding: International Society for Infectious Diseases. 10/2002-10/2005.

This study involves a multidisciplinary approach in ascertaining the existence of candidate SNPs in HRPII gene of Plasmodium falciparum isolates in Ibadan, Nigeria.

17.Microarrays analysis of fresh field isolates of drug resistant P. falciparum from Nigeria and Brazil.

Role: Principal Investigator. Funding: MR4/NIAD, USA. Period: 2004-2005.

The goal of this project was to use the microarrays technology for discerning temporal and geographical differential gene expression profiles in field isolates of P. falciparum from Nigeria and Brazil. Clustering of specific drug resistance patterns and gene expression responses to therapy were used to evaluate the relationship between treatment modalities and the development of unique drug resistant phenotypes.

18. Studies of Plasmodium falciparum genetic diversity in Nigeria.

Role: Co- Investigator. Funding: Exxon Mobil Corporation, USA. Period: 2002- 2005.

Efforts in this project were devoted in understanding genetic diversity of P. falciparum populations in various areas of Nigeria.

19. Validation of molecular markers, determinants and clinical relevance in chloroquine resistance P. falciparum infections in Benin Republic and Nigeria.

Role: Principal Investigator. Funding: WHO/TDR. 30/04/2001-30/10/2003.

The project focused on Identification and validation of mutations in targeted genes known to be associated with chloroquine resistance (Pfmdr1 and Pfcrt) and correlate the prevalence of these mutations with in vitro susceptibility of parasites to chloroquine and clinical response in patients in Nigeria and Benin Republic.

120. Intersectoral model for management, control and policy formulation on drug resistant malaria in Nigeria.

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Role: Co-investigator. Funding: WHO/MIM/TDR. Period: 03/1998- 12/2002

Efforts in this study are devoted to improving the clinical management of drug resistant malaria. Part of the study includes validation of a new diagnostic kit based on a biological phenomenon in the malaria parasites for detecting and documenting drug resistant parasites. The study also involves a collaborative network between the malaria research group, the Oyo state ministry of health, the Oyo state hospital management board and the development policy center.

03/03/2017