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VU Research Portal Pediatric acute lymphoblastic leukemia: Quality of life and cost-effectiveness of treatment van Litsenburg, R.R.L. 2012 document version Publisher's PDF, also known as Version of record Link to publication in VU Research Portal citation for published version (APA) van Litsenburg, R. R. L. (2012). Pediatric acute lymphoblastic leukemia: Quality of life and cost-effectiveness of treatment. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. E-mail address: [email protected] Download date: 14. Feb. 2021

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Page 1: Chapter 3 - research.vu.nl 3.pdf · Chapter 3!"#$%&’()*($%*+(,"-%./(%.,"01).(&-+#&2+.& 49 30"&+(4’256)7$#810(4+"9+2%#(:344;(%8(&6+(2)8&(0)22).(&’5+()*(06%$,6)),(0#.0+-+-(&6+(5#8&(,+0#,+8(8

VU Research Portal

Pediatric acute lymphoblastic leukemia: Quality of life and cost-effectiveness oftreatmentvan Litsenburg, R.R.L.

2012

document versionPublisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)van Litsenburg, R. R. L. (2012). Pediatric acute lymphoblastic leukemia: Quality of life and cost-effectiveness oftreatment.

General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.

• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ?

Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.

E-mail address:[email protected]

Download date: 14. Feb. 2021

Page 2: Chapter 3 - research.vu.nl 3.pdf · Chapter 3!"#$%&’()*($%*+(,"-%./(%.,"01).(&-+#&2+.& 49 30"&+(4’256)7$#810(4+"9+2%#(:344;(%8(&6+(2)8&(0)22).(&’5+()*(06%$,6)),(0#.0+-+-(&6+(5#8&(,+0#,+8(8

Chapter 3!"#"$%&'('#)*+,*-.(/&#0*+,*/&,"*1.$&'2*&'1.34+'*

#5"$(60*&'*6"1&(#$&3*(3.#"*/0%65+7/()43*/".8"%&(

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Page 3: Chapter 3 - research.vu.nl 3.pdf · Chapter 3!"#$%&’()*($%*+(,"-%./(%.,"01).(&-+#&2+.& 49 30"&+(4’256)7$#810(4+"9+2%#(:344;(%8(&6+(2)8&(0)22).(&’5+()*(06%$,6)),(0#.0+-+-(&6+(5#8&(,+0#,+8(8

!"#$%&'()48

Abstract 

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‐#.5&(/.(05,'&0A(*+$#/'&4(@,7(D#0(+,0%(,U&.(#00,5/#%&4(D/%"(,24&'(5"/24'&.(#.4(B/'20A(620,C(3#%"&'G'&0$,.4&.%0(0&&+(%,("#-&(#(2,D&'(@,7($&'5&$:,.(5,+$#'&4(%,(+,%"&'G'&0$,.4&.%0(#2%",1B"(%"/0(.&&40(%,(9&(5,.E'+&4(/.(31%1'&('&0&#'5"A([$&5/E5(5,1.0&2/.B(3,'(%"&0&(0190&%0(,3($#:&.%0(41'/.B(%"&(&#'28($"#0&0(,3(%"&'#$8(/0(D#''#.%&4A(

Page 4: Chapter 3 - research.vu.nl 3.pdf · Chapter 3!"#$%&’()*($%*+(,"-%./(%.,"01).(&-+#&2+.& 49 30"&+(4’256)7$#810(4+"9+2%#(:344;(%8(&6+(2)8&(0)22).(&’5+()*(06%$,6)),(0#.0+-+-(&6+(5#8&(,+0#,+8(8

Chap

ter 3

49!"#$%&'()*($%*+(,"-%./(%.,"01).(&-+#&2+.&

!"#$%&'()%"

30"&+( 4'256)7$#810( 4+"9+2%#( :344;( %8( &6+(2)8&( 0)22).( &'5+( )*( 06%$,6)),( 0#.0+-<(=>+-(&6+(5#8&(,+0#,+8(8"->%>#$(*)$$)?%./(&-+#&2+.&(*)-(06%$,6)),(344(6#8(%25-)>+,(8"7‐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‐.#.&8<(U6+(-+8"$&8()*(&6+(X-8&(#88+882+.&()*(!)4(#.,(%&8(,+&+-2%.#.&8(,"-%./(%.,"01).(&6+-#5'(#-+(-+5)-&+,(6+-+<(

Methods

*+),"#-

3($)./%&",%.#$(5-)85+01>+(2"$1B0+.&-+(0)6)-&(8&",'(?#8(,+8%/.+,<(_#-+.&8()*(06%$,-+.(*-)2( 8%\( )*( 8+>+.(O"&06( 5+,%#&-%0( ).0)$)/'( 0+.&+-8(?+-+( +.-)$$+,`( a22#( b6%$,-+.c8(W)85%&#$(30#,+2%0(d+,%0#$(b+.&+-(328&+-,#2G(e.%>+-8%&'(d+,%0#$(b+.&+-(f-).%./+.G(4+%,+.(e.%>+-8%&'(d+,%0#$(b+.&+-(4+%,+.G(R#,7)",(e.%>+-8%&'(d+,%0#$(b+.&+-(g%P2+/+.G(h%$6+$2%.#(b6%$,-+.c8(W)85%&#$(e.%>+-8%&'(d+,%0#$(b+.&+-(e&-+06&G(#.,(ie(e.%>+-8%&'(d+,%0#$(b+.&+-(328&+-,#2<(_#-+.&8()*(06%$,-+.(7+&?++.(&6+(#/+8()*(F(#.,(T@('+#-8(,%#/.)8+,(?%&6( 344( #.,( &-+#&+,( #00)-,%./( &)( &6+( O"&06( b6%$,6)),( =.0)$)/'( f-)"5(:Ob=f;( 344TA( 5-)&)0)$( ?+-+( +$%/%7$+<( _#-+.&8( ?+-+( -+L"%-+,( &)( 7+( Z"+.&( %.( O"&06<(

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Procedure

N'0/(O6%0>&'(PQQF(4++(O6%0>&'(PQQR($#'&-%3(0C(-&.+:(,*#5-03&,($#4&-%3(.&'&(*-E*%&,(%0($#'46*$#%&(*-(%"&(3%A,:8(S#'&-%3(.*++*-5(%0($#'46*$#%&(.&'&(#$$'0#6"&,(.*%"*-(%"&(T'3%(.&&J3(#K&'(,*#5-03*3(>:(0-&(0C(%"&($'*-6*$#+('&3&#'6"&'3(#-,('&6&*E&,(#,,*40-#+(E&'>#+(#-,(.'*U&-(*-C0'/#40-(0-(%"&(3%A,:8(D(>00J+&%(60-%#*-*-5(%"&(?0@(/&#3A'&3(#-,(#,,*‐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`(,#%#>#3&38(B02*6*%:(.#3(5'#,&,(#660',*-5(%0(%"&(Z#40-#+(!#-6&'(_-34%A%&(!0//0-(B02*6*%:(!'*%&'*#8(D++(3&'*0A3(%02*6*%:(75'#,&()1G;(,A'*-5(*-,A640-H60-30+*,#40-(%'&#%/&-%(.#3(*-6+A,&,(*-(%"&(#-#+:3*38(B"&(3%A,:(.#3(#$$'0E&,(0C(>:(&#6"(0C(%"&(/&,*‐6#+(&%"*6#+('&E*&.(>0#',3(0C(%"&($#'46*$#4-5(*-34%A40-38

Measures

S#'&-%1$'02:('&$0'%3(.&'&(60++&6%&,(A3*-5(#(5&-&'*6(#-,(#(,*3&#3&(3$&6*T6(*-3%'A/&-%8(B"&(9A%6"(E&'3*0-(0C(%"&(!"*+,(L&#+%"(?A&340--#*'&(7!L?;(]Q(*%&/3($#'&-%1C0'/(*3(#(5&-&'*6(?0@(#33&33/&-%(%00+(%"#%("#3(3"0.-(500,('&+*#>*+*%:(#-,(E#+*,*%:(abQc<(bQMd8(B"*3(*-3%'A/&-%(60E&'3(%"&($":3*6#+<(&/040-#+(#-,(306*#+(.&++1>&*-5(0C(6"*+,'&-(#-,(#++0.3(C0'(%.0(3A//#':(360'&3(7$":3*6#+(#-,($3:6"0306*#+;8(_%&/3(#'&(360'&,(A3*-5(#(C0A'(%0(3*2($0*-%(@*J&'%(36#+&(#-,(60-E&'%&,(%0(#(Q(%0(bQQ($0*-%(60-4-AA/<(.*%"("*5"&'(360'&3(*-,*‐6#4-5(>&U&'(?0@8(9A%6"(-0'/3(#'&(#E#*+#>+&(#-,(#++0.(C0'(#(60/$#'*30-(.*%"(%"&(9A%6"("&#+%":( $0$A+#40-( abQMd8( B"&( S&,*#%'*6( !#-6&'(?A#+*%:( 0C( @*C&( _-E&-%0':( )8Q%/(D6A%&(

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Chap

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TE+(,%P+-+.0+(%.(!)8(B+&D++.(&E+(\88(/-)"=(#.,(&E+(.)-2(D#5(*"-&E+-(+G=$)-+,(B'(0#$0"$#1./(&E+(."2B+-()*(\88(=#1+.&5(D%&E(#(0$%.%0#$$'(2+#.%./*"$(%2=#%-+,(!)8@(4#-.%(+&( #$@( QMMMS( =-+C%)"5$'( +5&#B$%5E+,( &E#&( %.( E+#$&E'( 0E%$,-+.( 50)-+5( ).+( UY( B+$)D( &E+(=)="$#1).(2+#.(%.,%0#&+(#(0$%.%0#$$'(2+#.%./*"$$'(%2=#%-+,(!)8F(5%.0+(&E%5(%5(5%2%$#-(&)(50)-+5( %.(#(=)="$#1).(D%&E(5+C+-+(0E-).%0(0).,%1).5@(c)$$)D%./(=-+C%)"5(-+5+#-0E(%.(&E%5(>+$,F(*)-(&E+(0)2=#-%5).()*()"-(0#.0+-(=)="$#1).(D%&E(E+#$&E'(3J!(.)-25(#(0"&<)P(=)%.&()*(<:UY(D#5(+2=$)'+,(QMX:F(MXOS@(c)-(&E+(7+,5!8F(#(0"&<)P()*(<MUY(D#5("5+,(5%.0+(&E+(0)2=#-%5).(D#5(2#,+(D%&E(0#.0+-(.)-25(#5()==)5+,(&)(E+#$&E'(.)-25@(

TE+( =)&+.1#$( ,+&+-2%.#.&5( )*( !)8( D+-+( 0$#55%>+,( %.&)( 0E%$,( 0E#-#0&+-%5105( 6#/+F(/+.,+-9F(&-+#&2+.&(0E#-#0&+-%5105(6,#'5(5%.0+(,%#/.)5%5F(-%5H(/-)"=F(#,2%55%).(,#'5(#.,(&-+#&2+.&(&)G%0%&'9(#.,(=#-+.&(0E#-#0&+-%5105(6#/+F(/+.,+-(#.,(E%/E+5&(+,"0#1).()*(&E+(-+5=).,+.&F(*#2%$'(5%&"#1).9@(T)(,+&+-2%.+(DE%0E(*#0&)-5(,+&+-2%.+(&E+(0)--+$#&+5()*(!)8F(>-5&(#(".%C#-%#&+($%.+#-(-+/-+55%).(#.#$'5%5(D#5(=+-*)-2+,@(c#0&)-5(#55)0%#&+,(D%&E(!)8(D%&E(#(=<C#$"+(dX@M(D+-+(+.&+-+,(%.(#(*)-D#-,(5+$+01).(2"$1=$+(-+/-+55%).(2),+$@(U%/.%>0#.0+($+C+$(D#5(5+&(#&(&D)<5%,+,(=dX@XW(*)-(#$$(#.#$'5+5@

Page 7: Chapter 3 - research.vu.nl 3.pdf · Chapter 3!"#$%&’()*($%*+(,"-%./(%.,"01).(&-+#&2+.& 49 30"&+(4’256)7$#810(4+"9+2%#(:344;(%8(&6+(2)8&(0)22).(&’5+()*(06%$,6)),(0#.0+-+-(&6+(5#8&(,+0#,+8(8

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Chap

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Table 3.1 [+2)/-#I@%0(L#-%#H$+4()*(&@+(I#-10%I#1./(EFF(I#1+.&4

\#-%#H$+ N \#$"+

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Chap

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55!"#$%&'()*($%*+(,"-%./(%.,"01).(&-+#&2+.&

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Discussion

A"0/(/%4,>( 0+<&/;*#%&,(B-C( 0+(:"0=,'&+(,4'0+*(GCC( 0+,4:;-+H:-+/-=0,#;-+(%'&#%E&+%(#+,(,&%&'E0+&,(.#:%-'/(#//-:0#%&,(D0%"(B-C@(B-C(#/(E&#/4'&,(D0%"(%"&(!IB(D#/(/%#;/‐;:#==>(0E$#0'&,(:-E$#'&,(%-(%"&("&#=%">(+-'E@(A"&(&J&:%(/0K&/(D&'&(=#'*&(#+,(:=0+0:#==>('&=&<#+%9(#/(,&E-+/%'#%&,(L>(%"&(=#'*&($&':&+%#*&/(-.(:"0=,'&+(D0%"(/:-'&/(4+,&'(MNOP(-.("&#=%">(+-'E/( Q555R@(S&+&'#==>9($">/0:#==>(-'0&+%&,(B-C(D#/(E-'&(-T&+( 0E$#0'&,(%"#+($/>:"-/-:0#==>(-'0&+%&,(B-C@(O0E0=#'('&/4=%/("#<&(L&&+('&$-'%&,(L>(O4+*(&%(#=@Q5U)R(

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Chap

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Chap

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