www.monash.edu 2015 Unit Guide CHE4171 Biochemical Engineering Quantitative and analytical skills required for biochemical and bioprocess engineering will be covered. The relationships between chemical engineering principles and approaches and biology will be explored. Knowledge about the operational considerations for suspended cultures, immobilized cultures, bioreactors, scaling, process selection, and operation of bioprocess unit operations will be discussed and worked on through calculations. Mode of DeliveryOn campus Workload requirements 2 hours lectures, 3 hours of practice sessions/tutor mediated group work/laboratory work and 7 hours of private study per week Unit RelationshipsRefer to handbook PrerequisitesCHE2165 (or BCH2011 or BMS1011 or BIO1011 or PSC2011 or PSC2041) and CHM1011 (or CHM1022 or CHM2735 or PSC1021 or PSC1022) Co-requisitesRefer to handbook ProhibitionsRefer to handbook Chief Examiner(s)Professor Karen Hapgood Unit Coordinator(s):Professor Tey Beng Ti (Unit Coordinator), Dr Edward Ooi Chien Wei (Co-Lecturer) Campus:Sunway Phone:03-55146240 (Prof Tey Beng Ti),03-55146201(Dr Edward Ooi Chien Wei), Email:tey.beng.ti@monash.edu, ooi.chien.wei@monash.edu, Office hours:9 am 5 pm Campus Coordinator Prof Tey Beng Ti (Sunway)/ Dr Lizhong He (Clayton)Campus:Sunway / ClaytonPhone:0355146240 / +61-3-99053437Email:tey.beng.ti@monash.edu Office Hours:9 am 5 pm Tutor(s)Miss Catherine Chang Campus:Sunway Phone: Email:chang.ching.han@monash.edu Consultation hours:10:00 am-12:00 noon Thursday SEMESTER 2, 2015 http://monash.edu/pubs/handbooks/units/CHE4171.html www.monash.edu Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 2 Your Feedback to Us Monashiscommittedtoexcellenceineducationandregularlyseeksfeedbackfromstudents,employersand staff.OneofthekeyformalwaysstudentshavetoprovidefeedbackisthroughtheStudentEvaluationof TeachingandUnits(SETU)survey.TheUniversitysstudentevaluationpolicyrequiresthateveryunitis evaluatedeachyear.Studentsarestronglyencouragedtocompletethesurveys.Thefeedbackisanonymous and provides the Faculty with evidence of aspects that students are satisfied and areas for improvement. For more information on Monashs educational strategy, see: www.monash.edu.au/about/monash-directions/directions.html and on student evaluations, see:www.policy.monash.edu/policy-bank/academic/education/quality/student-evaluation-policy.html

Previous Student Evaluations of this Unit In response to the last SETU of this unit, the following changes have been made: A group presentation has replaced literature review as the assignment. Student feedback has highlighted the following strength(s) in this unit:Great lecturers, great tutor, good subject. The tutorials are very useful, since marks are taken for attendance and work done, the students are 'forced' to attend and do the tutorial, which is actually very good for ourselves. Lecture Notes were well presented, clear and concise. Tutorials also helped in the overall learning process where the important concepts learnt in the lectures were practiced through sample questions. Submission of tutorials, this was really good,it made us really do the tutorials, which would otherwise been have not done and we end up printing the solution guide which may not contribute to be effective learning.Lecture notes/teaching syllabus/material are up-to-date with the latest biological technology with many case studies which widen our knowledge. If you wish to view how previous students rated this unit, please go to https://emuapps.monash.edu.au/unitevaluations/index.jsp ACADEMIC OVERVIEW Learning Outcomes On successful completion of this unit, students should be able to: LOs published in Unit HandbookRevised LOs for OBE analysis (Only applicable to Sunway Campus) 1.apply principles of fluid flow, mixing, heat transfer and mass transfer to analyse bioreactors 1.applyprinciplesoffluidflow,mixing,heattransfer and mass transfer to analyse bioreactors (PO1) 2.assesstheperformanceofbioreactorsand trouble-shoot operational problems 2.assesstheperformanceofbioreactorsandtrouble-shoot operational problems; (PO2)3. solve engineering problems related to the design and operation of bioreactors and bioprocesses; 3solveengineeringproblemsrelatedtothedesign andoperationofbioreactorsandbioprocesses; (PO2) 4.applyprinciplesofbiochemicalengineeringto analyseandassessspecialtopicssuchas syntheticbiology,animalandplantcellculture, and tissue engineering 5.solvetechnicalandpracticalissuesin commercial bioprocessing. 4.applyprinciples of biochemical engineering tosolve thetechnical,andpracticalissuesincommercial bioprocessing. (PO6) Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 3 Monash Graduate Attributes Monash has defined a set of Monash Graduate Attributes, which encompass more generic aspects of knowledge, skills and attitudes. Monash prepares its graduates to be: 1. responsible and effective global citizens who: a.engage in an internationalised world b.exhibit cross-cultural competence c.demonstrate ethical values 2. critical and creative scholars who: a.produce innovative solutions to problems b.apply research skills to a range of challenges c.communicate perceptively and effectively Program Education Objectives The School of Engineering expects its graduates to produce graduates, who have1.successful careers in ChemicalEngineering discipline 2.competencies to become professional engineers 3.the ability to work and communicate in globalized engineering teams 4.the capacity for life-long learning Program Outcomes The School of Engineering has developed a set of generic Program Outcomes (POs) for all of its graduates based on the Malaysian Engineering Accreditation Councils manual. Program Outcomes The Chemical Engineering discipline has developed a set of Program Outcomes (POs) for all of its graduates based on the Malaysian Engineering Accreditation Councils manual. Program OutcomesActivities used in this unit to develop program outcomes PO1 Engineering knowledge: Apply knowledge of basic science and engineering fundamentals and achieve specialization in Chemical Engineering discipline; Knowledgeiscoveredinthetheoreticallecture material,prescribedtextsandrecommendedreading. Applications of knowledge are covered in lectures and tutorials. (LO1) PO2 Problem solving and analysis: Identify, formulate, analyze and solve complex engineering problems; Thedescriptionandevaluationoftheperformanceof bioreactorsandtrouble-shoottheoperational problems of bioreactor (LO2); Learnhowtosolveengineeringproblemsrelatedto thedesignandoperationofbioreactorsand bioprocesses (LO3); PO3 Design/Development of solutions:Design solutions to complex engineering problems; N/A PO4 Research-based investigation of systems: Analyze complex engineering problems and systems using research-based knowledge and methods; N/A PO5 Modern tool usage:Create, select and apply appropriate techniques, resources and modern engineering and IT tools to complex engineering activities with an understanding of their limitations; N/A Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 4 PO6 Engineers and society:Assess social, public health and safety, cultural andlegal consequences of complex engineering solutions and relate them to the responsibilities of a professional engineer; The technical, and practical in commercial bioprocessing are covered in the selected special topics in topics in biochemical engineering, such as plant cell culture, animal cell cultures, and systems biology. (PO6) PO7 Environment and sustainability: Demonstrate knowledge of and need for sustainable development and understand the environmental impacts of engineering solutions; N/A PO8 Professional ethics:Apply ethical principles and commit to professional ethics and responsibilities and norms of engineering practice; N/A PO9 Communication:Communicate effectively both in oral and written forms; N/A PO10 Individual and team work: Function effectively as an individual and in multi-disciplinary and multi-cultural teams; N/A PO11 Lifelong learning:Recognise the need for independent and lifelong learning, and possess the capacity to do so; N/A PO12 Project management and finance: Manage an engineering project systematically; N/A Relationship between Unit Learning Outcomes and Program Outcomes PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11PO12 LO1 LO2 LO3 LO4 Key No emphasis Emphasized in the unit UNIT SCHEDULEWeekActivities Lecture: Wed - 08:00-09:00 am @9303 Thu -10:00-11:00 am @LT6008 Tutorial: Thu -14:00-16:00 @ 9305 Assessment 1 27/7-31/7 L1: Introduction to the Unit (TBT) L2: Metabolic Stoichiometry (TBT) T1: Metabolic Stoichiometry Tutorial 2 3/8-7/8 L3: Kinetics and mass balance (TBT) L4: Fermentor basics (TBT) Tutorial Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 5 T2: Kinetics and mass balance 3 10/8-14/8 L5:Fluid and mixing in bioreactor (TBT) L6:Shear effects (TBT) T3: Shear Problems Tutorial 4 17/8-21/8 L7: Heat Transfer in Bioreactors (EO) L8: Mass Transfer in Bioreactors (EO) T4: Heat and Mass Transfer in Bioreactors Tutorial 5 24/8-28/8 Test one - Wednesday 26 August 2015 L18: Guest lecture (Thu-10:00-11:00 am) Bioplastics from fermentation by Assoc. Prof. John Lan Chi-Wei, Yuan Ze University, Taiwan L9: Operating Considerations for Bioreactors (I) (TBT) (Thu-14:00-15:00 @ 9305) Test One Wednesday 26 August 2015 8:00-9:30 am 6 31/8-4/9 L10: Operating Considerations for Bioreactors (II) (TBT) L11: Time constants and regime analysis (I) (TBT) T5: Bioreactors and Time constants Tutorial 7 7/9-11/9 L12: Time constants and regime analysis (II) (TBT) L13: Sterilization (EO) T6: Regime analysis and sterilization Tutorial 8 14/9-18/9 16 September 2015 (Wednesday)-Malaysia Day L14: Synthetic biology (I) (EO) L15: Synthetic biology (II) (EO) T7: Briefing on group presentation Tutorial Short report for group presentationSubmission: 5 pm, Friday 18 September 2015 9 21/9-25/9 Test Two 8:00-9:30 am, Wednesday, 23 September 24 September 2015 (Thursday)- Hari Raya Haji (Eid Al-Adha) Test TwoWednesday, 23 September 2015 8:00-9:30 am Mid Semester break (26th Sept 4th Oct) 10 5/10-9/10 L16: Plant cell culture (EO) L17: Animal cell culture (EO) T8: Plant and animal cell culture and Unit revision Tutorial 11 12/10-16/10 14 October 2015 (Wednesday)- Awal Muharram (New Year) Group Presentation (Thursday) (EO/TBT) Presentation Thursday 15 October 2015 10:00-13:00 12 19/10-23/10 Unit revision and consultancy (EO/TBT) Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 6 SWOT VACNo formal assessment is undertaken in SWOT VAC Examination periodLINK to Assessment Policy: www.policy.monash.edu/policybank/academic/education/assessment/assessment-in-coursework-policy.html Assessment Summary Assessment TaskValueDue Date 1. Assignment 1: Tutorials10%At the end of each tutorial session 2. Assignment 2: Group Presentation that includes a) A short report on topic of the presentation b) A group presentation on the topic (a team of 4 students) 12% a) 3% for the short report b) 9% for presentation a)The short report5 pm Friday 18 September 2015 b)Final presentation 10:00-13:00 Thursday 15 October 2015 3. Test one13%8:00-9:30 Wednesday 26 August 2015 4. Test two13%8:00-9:30 Wednesday23 September 2015 5. Final exam50%Consult exam time table Studentsarerequiredtoachieveatleast45%inthetotalcontinuousassessmentcomponent(assignments, tests,mid-semesterexams,laboratoryreports)andatleast45%inthefinalexaminationcomponentandan overall mark of 50% to achieve a pass grade in the unit. Students failing to achieve this requirement will be given a maximum of 45% in the unit. Relationship between Unit Learning Outcomes and Assessments No.Learning OutcomesAssessment Assignment 1: Tutorials Assignment 2: Group Presentation Test OneTest TwoFinal Exam 1Beabletoapplyprinciplesoffluidflow, mixing,heattransferandmasstransfer to analyse bioreactors (PO1) C2C2C3 2Beabletoassesstheperformanceof bioreactors and trouble-shoot operational problems; (PO2)C2C3C2 3Beabletosolveengineeringproblems relatedtothedesignandoperationof bioreactors and bioprocesses; (PO2) C2C2C3C3 4Be able to apply principles of biochemical engineeringtosolvethetechnicaland practicalissuesincommercial bioprocessing. (PO6) C2C2C2C3 Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 7 Blooms Taxonomy: A committee of colleges, led by Benjamin Bloom, identified three domains of educational activities:oCognitive: mental skills (Head) oAffective: growth in feelings or emotional areas (Heart) oPsychomotor: manual or physical skills (Hand) The cognitive domain involves knowledge and the development of intellectual skills. This includes the recall or recognitionofspecificfacts,proceduralpatterns,andconceptsthatserveinthedevelopmentofintellectual abilities and skills. The affective domain includes the attitudes with which someone deals with things emotionally, such as feelings, values, appreciation, enthusiasms and motivations. Thepsychomotordomainincludesphysicalmovement,coordination,anduseofthemotor-skillareas. Developmentoftheseskillsrequirespracticeandismeasuredintermsofspeed,precision,distance, procedures, or techniques in execution. Key for the table above:Psychomotor:P1 (Low), P2 (Medium), P3 (High),Affective:A1 (Low),A2 (Medium), A3 (High),Cognitive: C1 (Low), C2 (Medium), C3 (High) Teaching and Learning Method This unit consists of lectures and tutorial classes. Learning in this unitis mainly through individual study of the content of the unit.Tutorial allocationThere is one 2-hours tutorial class each week, commencing in week 2. There will be an end-term review in week 10, and tutorial classes will be given in the lecturing hours as well as in the tutorial hour. Communication, participation and feedbackMonashaimstoprovidealearningenvironmentinwhichstudentsreceivearangeofongoingfeedback throughout their studies. In this unit it will take the form of group feedback via tutorials, individual feedback, peer feedback,self-comparison,verbalandwrittenfeedback,discussionsinclass.Students/Youareencouragedto draw on a variety of feedback to enhance their/your learning. ASSESSMENT REQUIREMENTS Assessment Tasks Task 1 Assignment 1 Tutorials (12%) Task 2 Assignment 2 - Group Presentation (12%) Task 3 Test One (13%) Task 4 Test Two (13%) Task 5 Final Exams (50%) Participation Task 1: Assignment 1 - Tutorials Due Date: 12:00-14:00 Thursday, at the end of each tutorial session.Details of task: You are required to solve tutorial problems in each tutorial session. You will need to sign a log book and hand your answer sheets to the tutors. There are 8 sessions of tutorials, and only 6 sessions which you perform best will be used for marking. Weight: 12% Each session will be marked out of 2 marks; 0.8 mark is given for attendance and 1.2 mark is based on efforts and quality of answers. Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 8 Task 2: Assignment 2 - Group presentation (a group of 4 students) Due Date: 1) the short report, 5pm Friday 18 September 2015, 2) final presentation, 10:00-13:00 Thursday, 15 October, 2015 Weight: 12% Details of taskStudentswillworkingrouptoprepareashortreportandanoralpresentation(15minforeachgroup)onthe innovative design of biologic or cellular systems using the principle of synthetic biology. Students have to identify anengineering/scientificprobleminanemergingarea(asshownbelow)wherethesyntheticbiologyis applicable, and propose the solution to the identified problem. List of areas having significant commercial and social importance: 1) Health sector (therapeutics and diagnostics) 2) Biotransformation (the manufacture of novel high value chemicals) 3) Bioremediation (environmental control) The short report (120-200 words) must state: 1) The scientific/engineering problem that the group is going to solve; 2) The area (health sector, biotransformation, and bioremediation) of the problem;3) List of 3-5 literature (patents or research articles) which are related to the problem and the area of research; 4) One single paragraph (100-150 words) to justify why you choose this problem to solve. Release dates (where applicable): N/A Word limit (where applicable): For the short report: 120 to 200 words in length excluding figures, tables, references and declaration of contribution (12 font, double spaced). Presentation requirements: For oral presentation: Each group must perform a 15-min oral presentation on the proposeddesigncoveringtheaspectssuchasproblemstatement,objective,literaturereviewandproposed methodology(designofcellularsystem,andselectionofhost/biobrick/plasimd)tosolvetheproblemthatis stated in the short report. Estimated return date: Short report- within two weeks of the submission date or after receipt, whichever is later. Final presentation results will be released by Friday 16 October 2015. Hurdle requirements:Students must attend all presentations and actively ask questions. Individual assessment in group tasks: N/A Multilevel distinction (where applicable): N/ACriteria for marking: Top mark will be awarded if following criteria are met Short report (3 marks)Marking criteria Technical understanding of the proposed topic The proposed topic shows the importance and significance of synthetic biology. Student shows in-depth understanding of all aspects of the proposed topic. All required information are provided. Presentation (9 marks) Problem statement and objective (2 marks) Problem statement is convincingly articulated with clear description of specific problem that leads to formulation of specific hypothesis/solution. Objectives are clearly and succintly described with high specificity. Literature review(3 marks) Summarizes and shows independent ability to provide insightful synthesis and analysis of the literature information of synthetic biology in general and the specified research area in particular. Proposed methodology(4 marks) Well-described methodology to achieve the objectives based on sound scientific method and strong justification. Demonstated innovative thinking in application of sythetic biology to solve the probelm. Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 9 Task 3:Test one Type: Test during class Due Date: 08:00-09:30 Wednesday 26 August 2015 Weight: 13% Perusal: 10 minutes Duration: 75 minutes Format: Multiple-choice, Short answer, Problem solving Task Description: Multiple choice, short answer and problem solving questions on lecture materials up to and including lecture 8. Task 4:Test two Type: Test during class Due Date: 08:00-09:30 Wednesday 23 September 2015 Weight: 13% Perusal: 10 minutes Duration: 75 minutes Format: Multiple-choice, Short answer, Problem solving Task Description: Multiple choice, short answer and problem solving questions on lecture materials including lectures 9-15. Examination(s) Final exam: consult exam time table. Learning resources Recommended text(s) and readings 1. Title: Bioprocess Engineering PrinciplesAuthor: Pauline M. DoranPublisher: Elsevier Edition: online version ISBN: 978-0-12-220855-3 An electronic version can be accessed at: http://www.sciencedirect.com/science/book/9780122208515 2. Title: Bioprocess engineering: basic concepts Author: Michael L. Shuler, Fikret Kargi Publisher: Upper Saddle River, NJ: Prentice HallDate: 2002Edition: 2nd ed.ISBN: 0130819085 Feedback to you Comments on tutorial problems, verbal feedbacks in the tutorial classes andlectures. Feedback will be given to the whole class if certain matter concerns all students. Extensions and penalties Tutorial answer sheets must be submitted to the tutors at the end of each tutorial session. You must sign tutorial log book to receive marking for each session. Late submission will not be marked. Returning assignments Standard solutions of tutorial questions will be uploaded on Moodle site after each tutorial session. Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 10 Resubmission of assignments No resubmission is allowed. Referencing requirements N.A. Required Resources N.A. Recommended Resources Monash online learning system https://my.monash.edu.au/teaching/learning-systems/ Field trips N.A. Additional subject costs N.A. Examination material or equipment A faculty approved calculator is permitted (meaning only scientific calculators that are not programmable and detailed in the list below will be permitted in the examination. These calculators must be checked by the faculty and have either a Faculty of Engineering or a Faculty of Science approved sticker) A list of the Faculty of Engineering approved calculators and the process for obtaining a sticker is available online at: www.eng.monash.edu.au/current-students/calculators.html

IMPORTANT: Only these listed calculators with the authorised Monash University-Science or Monash University-Engineering STICKER will be allowed into the examination by the invigilators. OTHER INFORMATION Policies Monash has educational policies, procedures and guidelines, which are designed to ensure that staff and students are aware of the Universitys academic standards, and to provide advice on how they might uphold them. You can find Monashs Education Policies at: www.policy.monash.edu.au/policy-bank/academic/education/index.html Key educational policies include: Student Academic Integrity Policy and Student Academic Integrity: Managing Plagiarism and Collusion Procedures ; Assessment in Coursework Programs; Special Consideration; Grading Scale; Discipline: Student Policy; Academic Calendar and Semesters; Orientation and Transition; and Academic and Administrative Complaints and Grievances Policy. Copyright Monash University 2015. All rights reserved. Except as provided in the Copyright Act 1968, this work may not be reproduced in any form without the written permission of the host Faculty and School/Department. 11 Graduate Attributes Policy http://www.policy.monash.edu/policy-bank/academic/education/management/monash-graduate-attributes-policy.html Student Charter All Monash Occupational Health & Safety Policies, procedures and Guidelines are available on the OHSwebsite (http://www.monash.edu.my/ohse/) The OHS website has information on: Occupational Health and Safety Policy at Monash, Emergency Guidelines for the Sunway Campus, Contacts, Emergency Hotline Numbers, List of Marshals and First Aiders. If you see something dangerous or hazardous on campus or if you are hurt during working hours, please report this to your lecturer / supervisor or call the emergency number 46333. For all emergencies on Sunway Campuses, please dial +603 5514 46333. Student Services TheUniversityprovidesmanydifferentkindsofservicestohelpyougainthemostfromyourstudies.Contact yourlecturerortutorifyouneedadviceandseetherangeofservicesavailableat http://www.monash.edu.my/Student-services/ TheLibraryandLearningCommons,MonashUniversitySunwayCampus,providesarangeofservicesand resourcesthatenableyoutosavetimeandbemoreeffectiveinyourlearningandresearch.Goto http://www.lib.monash.edu.my or the library tab in my.monash portal for more information. Disability Liaison Unit Academicsupportservicesmaybeavailableforstudentswhohaveadisabilityormedical condition.Registration with the Disability Liaison Unit is required. Further information is available as follows. Website: http://monash.edu/equity-diversity/disability/index.html; For information and referral, telephone: Sudent Adviser, Student Community Services at 0355146018; ordropIn:StudentCommunityServicesDepartment,Level2Building2,MonashUniversity,Sunway Campus. Email: dlu@monash.edu (Disability Liaison Unit, Monash University Australia)