Chem 509Signal Transduction

Winter 2010

Lecture 1

6 general classes of receptors

Ligand, agonist, antagonist

Autocrine, paracrine, endocrine: three mechanisms of signaling cells

Fight or Flight Response

http://monmouthfamilywellness.com/yahoo_site_admin/assets/images/fight-or-flight.107165735_std.jpg

Cholera

Vibrio cholerae

http://geo.arc.nasa.gov/sge/health/sensor/diseases/cholera.html

http://blackminis.wordpress.com/2008/12/12/winter-brings-infection/

AKAP: A kinaseanchoring protein

Protein Kinase A

Termination of beta adrenergic signaling pathway:

1. Epinepherine concentration is lowered.2. GAP activity of Gs alpha (GTP converted to GDP)3. cAMP phosphodiesterase4. Phosphorylation of beta-adrenergic receptor

-kinase is beta-adrenergic receptor kinase(BARK)-also known as G protein-coupled receptor kinase 2

5. Association of phosphorylated beta-adrenergic receptor with arrestin. This is followed by receptor endocytosis.

End of Lecture 1