cheminform abstract: synthetic analogues of sb-219383. novel c-glycosyl peptides as inhibitors of...

2001 carbohydrates carbohydrates U 0500 24 - 196 Synthetic Analogues of SB-219383. Novel C-Glycosyl Peptides as Inhibitors of Tyrosyl tRNA Synthase. — Novel inhibitors of bacterial tyrosyl tRNA synthetase are synthesized, in which the cyclic hydroxylamine moiety of the natural product SB-219383 is replaced by C-pyranosyl derivatives [cf. (IX)/(X)]. The L-arabinose-derived derivative (IX) is a potent and selective inhibitor of bacterial tyrosyl tRNA synthetase. — (BROWN, PAMELA; EGGLESTON, DRAKE S.; HALTIWANGER, R. CURTIS; JARVEST, RICHARD L.; MENSAH, LUCY; O’HANLON, PETER J.; POPE, ANDREW J.; Bioorg. Med. Chem. Lett. 11 (2001) 5, 711-714; SmithKline Beecham Pharm., New Front. Sci. Park, Harlow, Essex CM19 5AW, UK; EN) 1

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Page 1: ChemInform Abstract: Synthetic Analogues of SB-219383. Novel C-Glycosyl Peptides as Inhibitors of Tyrosyl tRNA Synthase

2001 carbohydrates

carbohydratesU 0500

24 - 196Synthetic Analogues of SB-219383. Novel C-Glycosyl Peptides asInhibitors of Tyrosyl tRNA Synthase. — Novel inhibitors of bacterialtyrosyl tRNA synthetase are synthesized, in which the cyclic hydroxylaminemoiety of the natural product SB-219383 is replaced by C-pyranosyl derivatives[cf. (IX)/(X)]. The L-arabinose-derived derivative (IX) is a potent and selectiveinhibitor of bacterial tyrosyl tRNA synthetase. — (BROWN, PAMELA;EGGLESTON, DRAKE S.; HALTIWANGER, R. CURTIS; JARVEST,RICHARD L.; MENSAH, LUCY; O’HANLON, PETER J.; POPE, ANDREWJ.; Bioorg. Med. Chem. Lett. 11 (2001) 5, 711-714; SmithKline BeechamPharm., New Front. Sci. Park, Harlow, Essex CM19 5AW, UK; EN)

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