chmi 2227 - e.r. gauthier, ph.d. 1 chmi 2227e biochemistry i introduction
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CHMI 2227 - E.R. Gauthier, Ph.D. 5
Example 1Myostatin deficiency and muscular development
Normal mouse Mighty mouse
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Example 2Leptin deficiency and obesity
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Boy with an inherited deficiency in the gene encoding leptin
- Top: at age 3
- Bottom: same boy, at age 8, after years of treatment with leptin
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Example 3:Hutchinson-Gilford Progeria Syndrome
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Ultrastructure of life - the AIDS virus
LipidsNucleic acidsProteinsSugars
http://en.wikipedia.org/wiki/Image:800px-HIV_Viron.png
CHMI 2227 - E.R. Gauthier, Ph.D. 9
Ultrastructure of life - A bacteria
LipidsNucleic acidsProteinsSugars
http://en.wikipedia.org/wiki/Image:Prokaryote_cell_diagram.svg
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Ultrastructure of life - A mammalian cell
1- Nucleolus Synthesis of ribosomes
2- Nucleus Contains DNA Site of DNA and RNA synthesis
3- Ribosome Contains RNA and proteins Site of protein sythesis
4 –secretory vesicle Transport
5- rough endoplasmic reticulum Cellular highway
6- Golgi appatarus Cellular highway Sugarland!
http://en.wikipedia.org/wiki/Image:Biological_cell.svg
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Ultrastructure of life - A mammalian cell
7- Cytoskeleton Scaffold
8- Smooth endoplasmic reticulum Cellular highway
9- Mitochondria Powerhouse
10 –Vacuole Storage
11- Cytoplasm Cellular Jello
12 – Lysosome Digestive organ of the cell
13 – Centriole Makes flagella/cilia Required during cell division
http://en.wikipedia.org/wiki/Image:Biological_cell.svg