cholestatic jaundice
TRANSCRIPT
Prepared by 32-Ahmed Samir
36-Ahmed Khattab 49-Ahmed Abdel-Wane
60-Ahmed Shahen66-Ahmed Atwa
Cholestasis
Extrahepatic (obstructive)
Intrahepatic (hepatocellular)
Extrahepatic (obstructive)
Lumen
Wall
Outside
Intrahepatic (hepatocellular)
hereditary
acquired
Causes :-lumen ....
Wall ….
A) Hereditary Dublin –Johnson syndrome Rotor’s syndrome Progressive familial intrahepatic
cholestasis syndromes
Autosomal recessive reduced ability to transport organic anions ….. liver biopsy dark pigment prognosis excellent
same as Dubin-Johnson syndrome except
*it’s autosomal dominant *there is no hepatic
pigmentation
heterogeneous group of conditions …. autosomal recessive the only cure Liver transplantation
B) Acquired Acute hepatitis Liver cirrhosis Drugs
-unconjugated hyperbilirubinemia-conjugated hyperbilirubinemia
Benign recurrent intrahepatic cholestasis
.Dark Urine
Pale Stool
Other symptoms
Pruritis
Yellowed Skin
Clinical Manifes-tations
Nausea vomiting Fever Pain in the abdomen Loss of appetite Fatigue Confusion Headache