Chromosome abnormalities and genetic counseling, 1989, 255 pages, R. J. M.Gardner, Grant R. Sutherland, 0195049322, 9780195049329, Oxford UniversityPress, 1989

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Chromosomal defects are one of the most common causes of genetic disorders and are responsiblefor a large proportion of miscarriages. As a result, more and more parents are becoming interestedin genetic counseling in order to learn about the risks of reproductive failure, or to understand whythey had a child with a particular defect, whether it will happen again, and what might be done toprevent it. This book addresses these and other questions concerning chromosome abnormalities.Although the book is written primarily for genetic counselors and laboratory workers incytogenetics, it will be of interest to all physicians concerned with genetic counseling. Each chapterdiscusses a different type of defect, such as translocations, duplications, insertions, deletions, andnon-disjunction. The basic biological theory underlying the problem is discussed and in-depthinformation is provided on the reproductive risks of chromosomally abnormal individuals and ofnormal parents who have a child with a chromosome abnormality. The book will help concernedparents determine an appropriate course of action, including prenatal diagnosis, and helpcounselors to communicate the information necessary for responsible decision-making.

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