ZEENAT KHAN2ND FACULTY OF MEDICINE

CHARLES UNIVERSITY

CIRCULATION CHANGES

AFTER BIRTHPhysiology 2014-15

FOETAL CIRCULATION

PLACENTA UMBILICAL VEIN DUCTUS VENOSUS INFERIOR VENA CAVA RIGHT ATRIUM FORAMEN OVALE LEFT ATRIUM LEFT VENTRICLE ASCENDING AORTA HEAD & UPPER BODY

FIG. #1

FOETAL CIRCULATION

SUPERIOR VENA CAVA RIGHT ATRIUM RIGHT VENTRICLE PULMONARY TRUNK DUCTUS ARTERIOSUS DESCENDING AORTA UMBILICAL ARTERIES PLACENTA

CIRCULATION AFTER BIRTH

FIG. #2

CHANGES OCCUR IN: -PULMONARY CIRCULATION

(LUNGS FUNCTIONAL)-SYSTEMIC CIRCULATION

(PLACENTA REMOVED)

… RESULTING IN CLOSURE OF:-FORAMEN OVALE-DUCTUS ARTERIOSUS-DUCTUS VENOSUS

CHANGES IN PULMONARY & SYSTEMIC CIRCULATION

(PULMONARY) BLOOD FLOW

ARTERIAL PRESSURE VASCULAR RESISTANCE

(SYSTEMIC) AORTIC PRESSURE LEFT VENTRICULAR

PRESSURE LEFT ATRIAL PRESSURE VASCULAR RESISTANCE

KEY FUNCTIONAL CHANGES AFTER BIRTH

12

3

45

1 & 2 – UMBILICAL CORD CLAMPED (CLOSURE OF UMBILICAL ARTERIES AND VEIN)3 – FORAMEN OVALE CLOSED.4 – DUCTUS ARTERIOSUS CLOSED.5 – DUCTUS VENOSUS CLOSED.

FIG. #3

CONSTRICTION OF UMBILICAL VESSELS

REASON:UMBILICAL CORD CUT TO DETACH NEONATE FROM PLACENTA , AS LUNGS ARE NOW FUNCTIONAL.METHOD:ARTERIES CONSTRICT INITIALLY; REDUCES FOETAL BLOOD LOSS TO THE PLACENTA .VEIN CONSTRICTS LATER; NUTRIENT-RICH BLOOD FROM PLACENTA CAN STILL REACH INFANT AFTER BIRTH.CONVERSION OF VEIN AND DISTAL PART OF ARTERIES TO FIBROUS LIGAMENTS .PROXIMAL PARTS OF UMBILICAL ARTERIES PERSIST, SUPPLYING URINARY BLADDER.

CLOSURE OF OVAL FORAMEN (CONNECTS R. TO L. ATRIUM)

REASON:PRESSURE DIFFERENTIALS BETWEEN LEFT AND RIGHT ATRIUM REVERSE (RIGHT: LOW//LEFT: HIGH)BLOOD PREVENTED FROM FLOWING LEFT TO RIGHT.METHOD:VALVE OF OVAL FORAMENT APPOSED WITH SEPTUM SECUNDUM, CREATING FOSSA OVALIS.*PATENT FORAMEN OVALE: (ASYMPTOMATIC) ATRIAL SEPTAL DEFECT

FIG. #4

CLOSURE OF DUCTUS ARTERIOSUS (CONNECTS PULMONARY A. TO AORTA)

REASON:INCREASE IN SYSTEMIC PRESSURE ; INCREASED PRESSURE IN LEFT SIDE OF HEART AND AORTA.DECREASE IN PULMONARY RESISTANCE; DECREASED PRESSURE IN PULMONARY ARTERIES.BLOOD PREVENTED FROM FLOWING FROM AORTA TO PULMONARY TRUNK.METHOD:SMOOTH MUSCLE CONSTRICTION (INDUCED BY INCREASED OXYGEN TENSION, RELEASE OF

BRADYKININ & REDUCTION IN CIRCULATING PROSTAGLANDINS)* PATENT DUCTUS ARTERIOSUM: (SYMPTOMATIC) DECREASED OXYGEN SATURATION OF AORTIC BLOOD.

FIG. #5

CLOSURE OF DUCTUS VENOSUS (CONNECTS UMBILICAL V. TO INFERIOR VENA CAVA)

REASON:FULL LIVER FUNCTION REQUIRED; PREVENTION OF ITS BYPASS BY BLOOD.

METHOD:CONTRACTION OF SPHINCTER NEAR UMBILICAL VEIN INCREASES PRESSURE IN PORTAL VEIN.CONVERSION TO FIBROUS LIGAMENT.

* PORTOSYSTEMIC SHUNT: (SYMPTOMATIC)FAILURE TO CLOSE, BLOOD CONTINUES BYPASSING LIVER.

FIG. #6

STRUCTURAL CHANGES

(FOETAL: ADULT)

UMBILICAL ARTERIES:DISTALLY: MEDIAL UMBILICAL LIGAMENTSPROXIMALLY: SUPERIOR VESICULAR ARTERIESUMBILICAL VEIN: LIGAMENTUM TERES HEPATISDUCTUS VENOSUM: LIGAMENTUM VENOSUMFORAMEN OVALE: FOSSA OVALISDUCTUS ARTERIOSUS: LIGAMENTUM ARTERIOSUM

FOETAL & ADULT CIRCULATION

(FOETAL)SHUNTS: DUCTUS VENOSUSDUCTUS ARTERIOSUSFORAMEN OVALE

OXYGENATION: VIA PLACENTA PVR: HIGHSVR: LOWHEART: CHAMBERS PUMP IN PARALLEL, RIGHT SIDE DOMINANT.

(ADULT)

REMNANTS; NON-FUNCTIONAL.

OXYGENATION VIA LUNGSLOW PVRHIGH SVRCHAMBERS PUMP IN SERIES, LEFT SIDE DOMINANT.

SUMMARY

Placental circulation provides foetus with oxygen and nutrients.

Pulmonary and systemic changes at birth lead to alterations in circulation in the neonate, enabling the infant to adjust to extra-uterine life.

Main changes include closure of the following, and eventual formation of their derivatives:

UMBILICAL VEIN (Lig. Teres Hepatis)UMBILICAL ARTERIES (DISTAL: Medial Umbilical

Ligaments, PROXIMAL: Superior Vesicular Arteries)

FORAMEN OVALE (Fossa Ovalis)DUCTUS ARTERIOSUS (Lig. Arteriosum)DUCTUS VENOSUS (Lig. Venosum)

FIG. #7

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REFERENCES

Barrett, K.E. et al, Ganong’s Review of Medical Physiology (24th Ed., McGraw-Hill, New York, 2012)Despopoulos, A. and Silbernagl, S., Color Atlas of Physiology, (6th Ed., Thieme, Stuttgart, 2009)Hall, J.E. and Guyton, A.C., Textbook of Medical Physiology (11th Ed., W.B. Saunders Company, Missisippi, 2006)Marcdante, K.J. and Kliegman, R.M., Nelson Essentials of Pediatrics (7th Ed., Elsevier Saunders, Philadelphia, 2015)Moore, K.L. et al, Before we are Born; Essentials of Embryology and Birth Defects (8th Ed., Elsevier Saunders, Philadelphia,

2013)Moore, K.L. and Persaud, T.V.N., The Developing Human; Clinically Oriented Embryology (9th Ed., Elsevier Saunders,

Philadelphia, 2011)Sadler, T.W., Langman’s Medical Embryology (12th Ed., Lippincott Williams and Wilkins, Philadelphia, 2012)Webster, S. and de Wreede, R., Embryology at a Glance (1st Ed., John Wiley & Sons, Oxford, 2012)

FIG #1: Before we are Born (p.219)FIG #2: Before we are Born (p.220)FIG #3: Embryology at a Glance (p.66)FIG #4: The Developing Human (p.331)FIG #5: Before we are Born (p.221)FIG #6: The Developing Human (p.330)FIG #7: Ganong’s Review of Medical Physiology