clinical trials registry : a tool to strengthen access to,and confidence in,clinical research...
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Clinical Trials Registry : A tool to strengthen access to ,andconfidence in ,clinical research
Gustavo Luiz F. Kesselring,MD
Gustavo Luiz F.Kesselring, MD
Disclosure• President Brazilian Society Of Pharmaceutical Medicine• Director Clinical Operations IBIC . Brazilian Clinical
Research Center• Current Clinical Investigator: Lilly ; Wyeth ; Stiefel ;
Sanofi-Aventis• Former Clinical Research Director Hoechst Marion
Roussel
REVISTA ÉPOCA, 07 DE AGOSTO DE 2006REVISTA ÉPOCA, 07 DE AGOSTO DE 2006
JAMA, Published online August 7, 2006
Reprinted) JAMA, Published online August 7, 2006
WHY MOST PUBLISHED RESEARCH FINDINGS ARE FALSE
Ioannidis, J.P.S. PLoS MEDICINE Vo. 2, No. 8: August 2005
DOI-10.1371/journal.pmed.0020124 http://medicine.plosjournals.org
WHY MOST PUBLISHED RESEARCH FINDINGS ARE FALSE. Ioannidis, J.P.S. PLoS MEDICINE Vo. 2, No. 8: August
2005
DOI-10.1371/journal.pmed.0020124 http://medicine.plosjournals.org
Corollary 5: The greater the financial and other interests and prejudices in a scientific field, the less likely the research findings are to be true
Conflicts of interest and prejudice may increase bias, u. Conflicts of interest are very common in biomedical research, and typically they are inadequately and sparsely reported. Prejudice may not necessarily have financial roots. Scientists in a given field may be prejudiced purely because of their belief in a scientific theory or commitment to their own findings.
WHY MOST PUBLISHED RESEARCH FINDINGS ARE FALSE. Ioannidis, J.P.S. PLoS MEDICINE Vo. 2, No. 8: August
2005
DOI-10.1371/journal.pmed.0020124 http://medicine.plosjournals.org
Corollary 5: The greater the financial and other interests and prejudices in a scientific field, the less likely the research findings are to be true
Many otherwise seemingly independent, university-based studies may be conducted for no other reason than to give physicians and researchers qualifications for promotion or tenure. Such nonfinancial conflicts may also lead to distorted reported results and interpretations.
PLoS Medicine | www.plosmedicine.org November 2005 | Volume 2 | Issue 11 | e378
,
JAMA 2004 292:1363-1363
International Standard Randomized Controlled Trial NumberISRCTN register
http://www.controlled-trials.com/isrctn/ 21/8/2006
ClinicalTrials.govNational Library of Medicine
http://www.clinicaltrials.gov/ 21/8/2006
July 2006 - The Secretariat of the Registry Platform, WHO,
Geneva, Switzerland
July 2006 - The Secretariat of the Registry Platform, WHO, Geneva, Switzerland
January 2005
January 2005
Clinical Trial Registration: The Differing Viewsof Industry, the WHO, and the Ottawa Group
www.plosmedicine.org November 2005 | Volume 2 | Issue 11 | e378
Clinical Trial Registration: The Differing Viewsof Industry, the WHO, and the Ottawa Group
www.plosmedicine.org November 2005 | Volume 2 | Issue 11 | e378
Clinical Trials Registry : A tool to strengthen access to ,and
confidence in ,clinical research
FUTURE?
Unique ?
Multiple?
WHO?
Clinicaltrials.gov ?
Controlled-trials.com/isrctn ?
Ifpma.org/clinicaltrials ?
Ottawa group ?
Others ?
.
PLoS Medicine | www.plosmedicine.org November 2005 | Volume 2 | Issue 11 | e378
