““Catch the Catch the Vision”Vision”

Cryptic Masons Cryptic Masons

Medical Medical Research Research

FoundationFoundation

General Grand Council, General Grand Council, Cryptic Masons, Cryptic Masons, InternationalInternational

The Vision

A World Class Philanthropy for

World Class Medical

Research

Your General Grand CouncilGeneral Grand Council, Cryptic Masons, International and Cryptic Masons Medical

Research Foundation is Advancing the Scope of

Atherosclerosis Research with the Cryptic Masons Chair in Vascular Biology Research.

Purpose of CMMRF Research is “BECAUSE”

Cardiovascular disease is the Number One Killer in the United States.

You Know Someone Who’s had a Heart Attack or Stroke.

You Are Committed to Improving Medicine for Future Generations.

YOU CARE.

Cryptic Masons Cryptic Masons Medical Research Medical Research FoundationFoundation

Since January 1, 1986 all contributions have been cumulative.

Located at Indiana University, Indianapolis, Indiana.

Many recognition levels for donations.

Donations are tax deductible. Your Donations will live forever.

They are “Never” spent.

Indiana Center for Vascular Biology& MedicineIndiana Center for Vascular Biology& Medicine(ICVBM)(ICVBM)

Cryptic Masons Medical Research CenterCryptic Masons Medical Research CenterIndiana University, Indianapolis,IndianaIndiana University, Indianapolis,Indiana

Mission Statement

The Indiana Center for Vascular Biology and Medicine (ICVBM) is committed to the rapid development, testing and extension to clinical application and commercialization of new knowledge in vascular biology. The ICVBM operates with the purpose of promoting research while impacting delivery of novel and innovative medical treatment in order to achieve positive results within the health care community.

General Grand Council, Cryptic Masons, International Has Already Accomplished With the ICVBM the Following in Vascular Biology:

1. Established a Center for Vascular Research. (ICVBM)

2. Establish Dr. March as Director of our Center. 3. Dr. March has more than 16 medical Patents 4. The “Closer”is being used on more than 500,000 patients annually. 5. Several Patents deal with the delivery of medicine to a damaged area. 6. Attracting a World Class Research Team to our Center. 7. The Research Team has over 300 Peer reviewed scientific publications to their credit.

Our Medical DirectorKeith March, M.D., Ph.D.

Dr. Keith March, M.D., Ph.D.

Born June 4, 1963 Five Children Indiana University Ph. D. 1983 with Highest Distinction Indiana University School of Medicine M.D./Ph.D. with highest Distinction

1985 Post Doctoral: Indiana U. Medical

Center Medical Article Author & Editorial

General Grand Council has donated over $1,884,000.00

World Class Researchers

Our Center includes clinicians, biologists, physicists, chemists, engineers, and technology transfer support. The participants within the center are also interacting with a highly complementary ensemble of industrial partners forming an overall consortium, with boundaries extending beyond the center itself.

Our Participants

Our key collaborators have been found at Indiana University, Methodist Research Institute, Indiana State University, Purdue University and Rose-Hulman Institute of Technology. These participants provide across-the-board applied research, technology and experimental design to support the basic science projects.

Research Medical Team

Dr. Dongming Hou M.D., Ph.D. -

People’s Repub. of China; Post Doc – Univ. of Heidelberg,Germany Asst. Scientist – IU

Investigating the mechanism of restenosis and examining techniques to prevent it.

Research Medical Team

Dr. Dan Meldrum

M. D. Michigan State Residency, Univ. of

Colorado; Fellowship, Johns Hopkins University

Asst. Prof. of Surgery at Indiana University.

Dr Meldrun’s Research Team

Standing from Left:Rajakumar SankulaAshley Streitmatter

Seated from Left:Meijing WangBen Tsai

Dr. Dan Meldrum’s Research

Investigating the mechanism of how the heart produces cell damaging cytokines (agents) during heart attacks or heart surgeries and targeting therapies to determine if blocking cytokines such as tumor necrosis factor (TNF) aids the heart.

Dr. Meldrum has authored over 100 peer reviewed scientific publications.

Research Medical Team

Dr. Jalees Rehman

Dr. Rehman's Research

The Rehman lab is currently researching the biology of endothelial progenitor cells as well as other stem and progenitor cells in the cardiovascular system.

The goal is to understand the physiological role of such cells in a healthy environment as well as how diseases can impact such cells. Understanding the biology of progenitor and stem cells may lead to novel cardiovascular therapies based on the modification of endogenous cells, and thus complement current cell therapies that involve cell transplantation.

Dr. Jalees Rehman

M.D. Munich, Germany; Post Doc. At Univ. of Calif.; Residency at IU Internal Med.; Cardiology Fellow, IU

Investigating the role of stem cells and progenitor cells in cardiovascular disease. Also studying growth factors secreted by fat tissue to investigate the relationship between obesity and heart disease.

Dr. Mike Murphy

Adult Stem Cells a vascular

surgeon from Duke University

Peripheral artery disease (PAD)

Enrolled five patients in the Phase I (safety) trial

Research Medical Team Dongni Feng, Research Technician

Studying molecular mechanisms directing artery remodeling

NanKai University, People’s Republic of China

Research Medical TeamCatharine Williams, Lab. Tech.

Animal Science, Purdue University

Cell isolation to differentiate cultured cells

General Laboratory support and cell culture experiments.

Dr March consults with Emily Judy an IU student learning about vascular research.

What are our current projects?

“I am looking at ways for people to grow new blood vessels (angiogenesis) using special delivery methods for genes and even using one’s own cells to convey the genes. I like to think that researchers today are working to develop the medicine for tomorrow.”

Dr. March 7-12-2002

CMMRF Director’s Projects:

1. The “Closer” 2. Stimulating vessel growth around the heart. 3. Extensive research investigating the role of a variety of genes and cells and how they interact in vascular biology. 4. Implement clinical programs to provide excellent care to patients with all vascular diseases.

“The Closer”A Completed successful Cryptic Masons Director’s Medical Project

ICVBM Project #1 The Closer

The Vascular Closer

Patent in place and completed Produced by Abbott Vascular 500,000 sold in 2001 Increased production in the future Royalties returned to CMMRF

Medical Center at Indiana University (IVCBM).

ICVBM Project #2

Recently ICVBM investigators have been experimenting with a groundbreaking technique to extract a special population of a patient’s own cells from the fat tissue using liposuction. We have found that we can select cells that are like stem cells and may soon be able to re-introduce them into the patient’s heart to enhance the growth of new blood vessels and possibly regenerate heart tissue.

ICVBM Project #3Electronic Pulsation Device

Non-Invasive device that uses electronic pulses to stimulate cell growth that produces a natural bypass around trouble areas in the coronary arteries.

Project #4 Adult Stem Cell Mediated Angiogenesis Study

Dr. Murphy has enrolled five patients in the Phase I (safety) trial where patients’ own adult stem cells are extracted from the hip bone before being injected into the leg along the calf. Four additional patients are scheduled for treatment in February 2006.

Current articles listed on our Website www.cmmrf.orgwww.cmmrf.org

Dr Murphy’s Stem Cell Mediated Angiogenesis Study

Why is our research so Important?

“Due to the length of time involved in developing a device like the Closer, it is necessary to think way ahead and advance research solutions to hasten clinical applications. To shorten this process, research dollars are critical. The more parallel efforts in place, the quicker solutions are found.”

Dr. March 7-12-2002

Maintaining open arteries after Angioplasty

One novel approach being developed and tested in the ICVBM involves the use of devices emitting ultrasound energy inside arteries following stenting to help perform gene therapy and keep such vessels open.

Early diagnosis of Coronary Artery Disease

Your ICVBM investigators are developing techniques that will detect early abnormalities in the blood vessels by imaging inflamed areas of blood vessels entirely non-invasively.

Our Cryptic Mason Goals

1. Continued monetary support of the ICVBM.

2. $10,000,000 Foundation corpus for continued funding of future research.

3. Your commitment/pledge today will ensure our future success.

Visit our Website for more information

www.cmmrf.orgwww.cmmrf.org

Cryptic Masons Medical Research Foundation

“What We Have Done For Ourselves Alone Dies With US; What We Have Done For Others And The World Is Immortal”

Albert Pike

General Grand Council, Cryptic Masons,

International Cryptic

Freemasonry and World Class Medical Research

Working together for Tomorrow's

“Visions”

Created for our future by Andrew R. Jackson, PIM IndianaCMMRF Graphic by Stephen McKim, CM Indiana Copywrite protected