colitis in a population-based cohort from olmsted county, minnesota, 1970–2001 number:op-g-343...
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COLITIS IN A POPULATION-BASED COHORT FROM OLMSTED COUNTY, MINNESOTA, 1970–2001
Number:OP-G-343Authors: Ingle S.B.1, Dhillon S.1, Harmsen W.S.1, Zinsmeister A.R.2, Sandborn W.J.1, Tremaine W.J.1, Loftus E.V.1Institutions: 1Gastroenterology and Hepatology, 2Biostatistics, Mayo Clinic College of Medicine, Rochester, United States
año población urbana
1970 84.104 64%
2001 124.277 69%
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COLITIS IN A POPULATION-BASED COHORT FROM OLMSTED COUNTY,
MINNESOTA, 1970–2001• Retrospectivo
(revisión de historias clínicas, con identificación de actos quirúrgicos).
• Segundos tiempos quirúrgicos se excluyeron.
• Se valoraron cirugías imprevistas.
• Tipos de colectomía:• Panproctocolectomía
total con anastomosis ileoanal: IPAA
• Panproctocolectomía total: TPC con ileostomia
• Colectomia subtotal SC
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• Se calcula:– Incidencia acumulada de colectomía inicial
(método de Kaplan-Meier).– Asociación de variables clínicas y
demográficas que influyan tanto en el tiempo de colectomía como en el seguimiento después de la misma.
COLITIS IN A POPULATION-BASED COHORT FROM OLMSTED COUNTY,
MINNESOTA, 1970–2001
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Risk (95% CI) IPAA TPC-ileo All
Cum. 10-yr risk colectomy from dx 10.7 (6.6–14.7) 4.9 (2.1–7.6) 16.5 (11.7–21.3)
Cum. 20-yr risk colectomy from dx 12.1 (7.6–18.4) 5.9 (2.5–10.2) 19.6 (14.0–26.5)
Cum. 10-yr risk unplanned surg 49.7 (25.7–59.3) 34.1 (0–56.9) 44.1 (25.7–59.3)
COLITIS IN A POPULATION-BASED COHORT FROM OLMSTED COUNTY,
MINNESOTA, 1970–2001n=316 (57% hombres)53 (16%) se operaronDe ellos 37 (69.8%) precisaron más de una intervenciónLos hombres se operaron más (HR: 2.2; 95% IC 1,67-6,5)La extensión (pancolónica vs izquierda) no es predictor (HR 1,4 95% IC, 0,7-2,6)
Si es predictor el uso de corticoides en los 3 primeros meses (HR 3,2, IC 1,6-6,5)
IPAA: 62%TPC: 30%SC: 6%Colectomía segementaria: 2%
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COLITIS IN A POPULATION-BASED COHORT FROM OLMSTED COUNTY,
MINNESOTA, 1970–2001
CONCLUSIONES
A los 20 años el riesgo acumulado de colectomìa es de 20%.
Sexo masculino y uso temprano de esteroides está asociado a colectomía.
Las IQ más precuentes : panproctocolectomia total con reservorio ileal y panproctocolectomía total con ileostomía.
Frecuentes cirugías no planeadas Imprevistas
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CHARACTERISTICS OF RESECTIONAL SURGERY IN A POPULATION-BASED INFLAMMATORY BOWEL DISEASE COHORTNumber:OP-G-345Authors: Chang H.1, Gearry R.B.1, Reilly M.J.1, Barclay M.L.1, Frizelle F.A.2Institutions:1Medicine, 2Surgery, Christchurch School of Medicine, Christchurch, New Zealand
Canterbury: 464.800 habitantesCohorte de 1421 pacientes (91% de los pacientes con EII de la zona)
Gut 2007; 56 (Suppl III) A81
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Christchurch350.000 habitantes
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CHARACTERISTICS OF RESECTIONAL SURGERY IN A POPULATION-BASED
INFLAMMATORY BOWEL DISEASE COHORT• Excluidos pacientes con diagnóstico incierto o
inespecífico quedaron:• Enf. De Crohn:
– n: 218/649 (33.6%)
– Edad• Edad<17 a. al diag (A1): 1.75 (IC 95%: 1.07-2.9)
veces + frec. la resección que 17-40 (A2) y 3.1 (IC 95% 1.78-5.42) que >40 (A3).
• Comportamiento:– B2 (estenosante) vs B1(no complicada): OR:18.6 (IC
95%– B3 (penetrante) vs B1: 70.4 (IC 95% 33.5-148)
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• Localización:– L3 (ileocolónica) comparada con L1 (ileal) OR=2.03 (IC 95%
1.27-3.25)– L3 comparada con L2 (colónica) OR=6.94(IC 95% 4.23-10.7)
• 39% de los intervenidos + de una resección.
• Los pacientes clasificados como A1,B3,L1 son los que antes se operan
• 36/649 (5.6%): estoma permanente (36 de 218: 16%)
CHARACTERISTICS OF RESECTIONAL SURGERY IN A POPULATION-BASED
INFLAMMATORY BOWEL DISEASE COHORT
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CHARACTERISTICS OF RESECTIONAL SURGERY IN A POPULATION-BASED
INFLAMMATORY BOWEL DISEASE COHORT
• CU: 109/668 se operaron (16.3%)
Joven OR=1.78(0.84-3.76)
Extensión (E3) OR=3.49(2.27-5.35)
42 /668 (6.3%) tienen estoma permanente. 38,5% de los intervenidos
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OUTCOME AFTER PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS FOR
ULCERATIVE COLITIS
Number: OP-G-348
Authors: Fante M.1, Declerck.1, Penninckx F.2, Rutgeerts P.1, Van Assche G.1, D’Hoore A.2, Vermeire S.1
Institutions: 1Department of Gastroenterology, 2Department of Abdominal Surgery, University Hospital Gasthuisberg, Leuven, Belgium
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• Resultados obtenidos en los pacientes sometidos a cirugía resectiva más reservorio en un centro de referencia belga.
• Intentar encontrar factores predictores de complicaciones evolutivas tras la intervención a corto y largo plazo (reservoritis).
• 187 pac. Intervenidos entre 1999-2004 (14 años).
• Estudio de variables clínicas y aspectos genéticos (receptores de reconocimiento bacteriano) y batería inmunológica (pANCA, ASCA, ALCA, ACCA, AMCA), esto en 145 pac.
OUTCOME AFTER PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS FOR
ULCERATIVE COLITIS
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• Seguimiento en 173 de 184• 67 mujeres, edad media en el momento
quirúrgico: 39 años.• Mortalidad temprana postoperatoria: 0• Complicaciones tempranas: 27%(4 sangrado
severo y 43 complicaciones inflamatorias).• Öresland score: al año: 3 (0-11).• La media de seguimiento fue de 6.5 años(3.4-
9.9) y 35% tuvieron complicaciones sépticas u obstructivas con predominio en los de edad avanzada en el momento de lo intervención (p=0.017) y cirugía múltiple
OUTCOME AFTER PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS FOR
ULCERATIVE COLITIS
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OUTCOME AFTER PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS FOR
ULCERATIVE COLITIS
• 46% desarrollaron pouchitis• Factores de riesgo independientes:
Manifestaciones extraintestinales
OR 2.16 (1.07–4.37), p = 0.033
Reconstrucción bolsa tras la intervención OR 2.54 (1.08–5.98), p = 0.033
Alelo T del TLR1 S87I OR 2.09 (1.03–4.23), p = 0.041
Edad joven en la intervención p = 0.015
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OUTCOME AFTER PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS FOR
ULCERATIVE COLITIS
• 33 pacientes 19% desarrollaron pouchitis crónica• Factores de riesgo independientes:
Genotipo CD14-260TT OR 4.26 (1.16–15.63), p = 0.028
Tiempo de seguimiento (p = 0.004)
Fallo de la bolsa en 9 pacientes (5%)
TLR1 y CD14, forman parte del complejo de la liposacaridasa
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EVALUATION OF FECAL LACTOFERRIN, CRP AND ACTIVITY INDICES FOR ASSESSING
THE PRESENCE OF INTESTINAL INFLAMMATION IN IBD AND IBS PATIENTS CLASSIFIED BY
ILEOCOLONOSCOPY
Number: MON-G-269
Authors: Langhorst J.1, Boone J.H.2, Koelzer J.1, Rueffer A.3, Michalsen A.1, Dobos G.J.1
Institutions: 1Department of Internal and Integrative Medicine, University of Duisburg-Essen, Kliniken Essen-Mitte, Essen, Germany, 2Research and Development, Techlab, Inc, Blacksburg, USA, 3Enterosan, Labor L+S,Bad Bocklet-Großenbrach, Germany
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• Conocer la actividad de la EII ayuda a la optimización del tratamiento.
• A veces diferenciar SII de EII puede ser dificultoso, en estos casos a veces se demora 4 años el diagnóstico.
• La PCR y la VSG tienen una baja sensibilidad y especificidad para “marcar la inflamación intestinal.
• La lactoferrina y las proteinas de los neutrófilos se han mostrado como un marcador sensible para discrminar entre EII y SII.
EVALUATION OF FECAL LACTOFERRIN, CRP AND ACTIVITY INDICES FOR ASSESSING THE PRESENCE
OF INTESTINAL INFLAMMATION IN IBD AND IBS PATIENTS CLASSIFIED BY ILEOCOLONOSCOPY
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• Comparar la lactoferrina fecal con la PCR, los indices clínicos de actividad, la ileocolonoscopia y la histologia, para intentar conocer el grado de afectación de la enfermedad.
• 97 pacientes; Edad media 42 años, ♂/♀ 1:2 • ileocolonoscopia y a. patologica. score: 0–3 (0 = normal
y 3= inflamación importante). • Colitis ulcerosa: Colitis Activity Index (CAI –
Rachmilewitz-Index; una puntuacíón>5 indica actividad de la enfermedad
• Para la EC: (CDAI; una puntuaión >150 = enfermedad activa).
EVALUATION OF FECAL LACTOFERRIN, CRP AND ACTIVITY INDICES FOR ASSESSING THE PRESENCE
OF INTESTINAL INFLAMMATION IN IBD AND IBS PATIENTS CLASSIFIED BY ILEOCOLONOSCOPY
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EVALUATION OF FECAL LACTOFERRIN, CRP AND ACTIVITY INDICES FOR ASSESSING THE PRESENCE
OF INTESTINAL INFLAMMATION IN IBD AND IBS PATIENTS CLASSIFIED BY ILEOCOLONOSCOPY
PARA INFLAMACIÓN INTESTINAL
SENSIB ESPECIF
PCR 62 71
LACTOFERRINA 83 76
CAI 88 57
CDAI 25 100
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EVALUATION OF FECAL LACTOFERRIN, CRP AND ACTIVITY INDICES FOR ASSESSING THE PRESENCE
OF INTESTINAL INFLAMMATION IN IBD AND IBS PATIENTS CLASSIFIED BY ILEOCOLONOSCOPY
3 vs 1 3 vs 0 1 vs 0
PCR p = 0.02 p = 0.005
LACTOFERRINA p = 0.04, p = 0.02 p = 0.0002,
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FECAL CALPROTECTIN, LACTOFERRIN AND ENDOSCOPIC DISEASE ACTIVITY IN MONITORING
TNF-ALPHA ANTAGONIST THERAPY IN PATIENTS WITH CROHN'S DISEASE
Number: MON-G-279
Authors: Spoken T.M.1, Savilahti E.2, Kolho K.2, Nuutinen H.1, Turunen U.1, Färkkilä M.1
Institutions: 1Gastroenterology, 2Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
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• La curación mucosa puede ser una diana terapéutica en el tratamiento con Anti TNF-a, pero es necesario hacer endoscopia para su confirmación.
• Las proteinas fecales provenientes de los neutrófilos como calprotectina y lactoferrina, podrían ser sustitutos no invasivos. Su comportamiento en los caos de E. de Crohn tratados con antagonistas TNF-alfa está por estudiar.
FECAL CALPROTECTIN, LACTOFERRIN AND ENDOSCOPIC DISEASE ACTIVITY IN MONITORING
TNF-ALPHA ANTAGONIST THERAPY IN PATIENTS WITH CROHN'S DISEASE
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FECAL CALPROTECTIN, LACTOFERRIN AND ENDOSCOPIC DISEASE ACTIVITY IN MONITORING
TNF-ALPHA ANTAGONIST THERAPY IN PATIENTS WITH CROHN'S DISEASE
n= 13Evaluación
Endoscópicapretratamiento
n=12) 2 bolus de infliximab a 0 y 8 semanas
(n=1) adalimumab c/15 d
EndoscopiaCDEIS
A la 12 y 10 sem respect.Calprotectina
lactoferrina
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FECAL CALPROTECTIN, LACTOFERRIN AND ENDOSCOPIC DISEASE ACTIVITY IN MONITORING
TNF-ALPHA ANTAGONIST THERAPY IN PATIENTS WITH CROHN'S DISEASE
CDEIS (range) CDAI (range) Fecal
calprotectin μg/g (range)
Fecal lactoferrin μg/g (range)
Antes ttº 12.1 (1.8–25.3) 153.5 (49–605) 1081 (88–2775) 92.38 (4.2–419.5)
Despues ttº 3.4 (0.0–11.2)* 60.0 (30–202)** 125 (13–1052)* 2.20 (0.0–93.4)*
* p < 0.01, ** p = 0.016
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CROHN'S DISEASE ACTIVITY ASSESSED BY FECAL CALPROTECTIN AND LACTOFERRIN: CORRELATION
WITH CROHN'S DISEASE ACTIVITY INDEX AND ENDOSCOPIC FINDINGS
Number: MON-G-280
Authors: Siphoned T.M.1, Savilahti E.2, Kolho K.2, Nuutinen H.1, Turunen U.1, Färkkilä M.1
Institutions: 1Gastroenterology, Helsinki University Central Hospital, 2Gastroenterology, Hospital of Children and Adolescents, Helsinki, Finland
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CROHN'S DISEASE ACTIVITY ASSESSED BY FECAL CALPROTECTIN AND LACTOFERRIN: CORRELATION
WITH CROHN'S DISEASE ACTIVITY INDEX AND ENDOSCOPIC FINDINGS
Necesitamos instrumentos para evaluar la actividad de la E.C. La endoscopia es el sistema mejor para valorar la
inflamación intestinal pero es invasiva y consume tiempo.La concentración fecal de las proteinas derivadas de
losneutrófilos como calprotectina y lactoferrina reflejan el incremento del flujo de neutrófilos a través de la pared intesinal hacia la luz. La correlación con los hallazgos
endoscòpicos esta por estudiarse.
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• Comparar calprotectina y lactoferrina con CDEIS
• A 77 pacientes con EC se le practicaron 106 ileoscopias, se clasificaron según CDEIS y se determinó calprotectina, lactoferrina, PCR y se calculó CDAI cada vez.
CROHN'S DISEASE ACTIVITY ASSESSED BY FECAL CALPROTECTIN AND LACTOFERRIN: CORRELATION
WITH CROHN'S DISEASE ACTIVITY INDEX AND ENDOSCOPIC FINDINGS
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CROHN'S DISEASE ACTIVITY ASSESSED BY FECAL CALPROTECTIN AND LACTOFERRIN: CORRELATION
WITH CROHN'S DISEASE ACTIVITY INDEX AND ENDOSCOPIC FINDINGS
CDEIS Fecal calprotectin μg/g (95% CI)
Fecal lactoferrin μg/g (95% CI)
CDAI(95%CI)
CRP mg/l <3 (inactive)
Normal n = 36 63 (40–88) * 1.92 (0.62–2.83)* 60 (45–78) 0 (0–0)
3–9 (leve) n = 38 170 (99–451)* 6.84 (4.09–12.65)* 69 (48–99) 0 (0–0)
9–12 (moderado) n=16 1014 (219–1484)* 68.48 (22.19–109.03)* 94 (41–222) 8.5 (0–23)
≥12 (grave) n = 16 2066 (1016–2588)* 253.64 (92.36–521.7)* 171 (102–
7)** 16.5 (7–54)**
* p < 0.05 between all activity groups, ** p < 0.05 between inactive or mild with severe
Correlación CDEIS calprotectin: Spearman's r 0.729 Correlación CDEIS lactoferrina: 0.773 p < 0.001)
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