comple men

8/17/2019 Comple Men

1/37

SISTEM KOMPLEMENSISTEM KOMPLEMEN


2/37

Complement: HistoryComplement: History

Discovered in 1894 byDiscovered in 1894 by

BordetBordet

It represents lyticIt represents lyticactivity of fresh serumactivity of fresh serum

Its lytic activity isIts lytic activity is

destroyed whendestroyed when

heated at !C for "#heated at !C for "#

minmin


3/37

Complemen :Complemen :

$erup% $ol% Dari sistem imun non spesi&'$erup% $ol% Dari sistem imun non spesi&'larutlarut

Ditemu'an dlm sir'ulasi dlm 'eadaan non a'tif Ditemu'an dlm sir'ulasi dlm 'eadaan non a'tif

(etiap saat dpt dia'tif'an oleh berba)ai(etiap saat dpt dia'tif'an oleh berba)ai

bahan:bahan: *)%+ 'omple, imun+*)%+ 'omple, imun+

Hasil a'tifasi 'omplemen : mediator 'imiaHasil a'tifasi 'omplemen : mediator 'imia

a'tif%a'tif%

-alur a'tivasi 'omplemen serin) disertai -alur a'tivasi 'omplemen serin) disertai

'erusa'an .arin)an / meru)i'an diri sendiri 0%'erusa'an .arin)an / meru)i'an diri sendiri 0%


4/37

Complement unctions

2 Host

detriment:

In3ammation

*naphyla,is

i)ure1% Complement has a central role inin3ammation as it causes chemota,is of pha)ocytes+

opsoni5ation and lysis of patho)ens and clearence ofimmune comple,es%


5/37

Ch% 6

p% 1!9


6/37

Ch% 184


7/37Ch% 6


8/37Ch% 6


9/37

Ch%6


10/37

Ch%6


11/37

Ch%6

p% 18!


12/37

7roteins of the complement7roteins of the complementsystemsystem /nomenclature0/nomenclature0

2 C1/rs0+ C+ C"+ C4+ C+ C!+ C6+ C8+ C9

2 factors B+ D+ H and I+ properdin /70

2 mannose bindin) lectin /$B0+ $Bassociated serine proteases /$*(71$*(70

2 C1 inhibitor /C1I;H+ serpin0+ C4bindin)protein /C4B70+ decay acceleratin) factor

/D*0+ Complement receptor 1 /C


13/37

$=DI*>??


14/37

Biolo)ical e@ects ofBiolo)ical e@ects ofCaCa


15/37

1% *;*I*>?A(I;1% *;*I*>?A(I; Bhn d)n B$ 'ecil dapat meninb% De)ranulasiBhn d)n B$ 'ecil dapat meninb% De)ranulasi

mastositbaso&l + menyeb pen)lepasan histaminmastositbaso&l + menyeb pen)lepasan histamin

Histamin menin)'t'n permiabilitasHistamin menin)'t'n permiabilitas

vascular'ont%otot polos meninmb% e.alavascular'ont%otot polos meninmb% e.ala

)e.ala rea'si aler)i)e.ala rea'si aler)i

7enin)'atan permiabilitas vascular menimb% =dem7enin)'atan permiabilitas vascular menimb% =dem

a'ulmulasi cairan dlm .ar% a'ulmulasi cairan dlm .ar%

% A=$?>*A(I;% A=$?>*A(I;$erup% Bahan bahan y) dpt menari'$erup% Bahan bahan y) dpt menari'

men)erah'an sel sel fa)osit% C"a+Ca men)erah'an sel sel fa)osit% C"a+Ca C!6 merupa'an 'emota'sinC!6 merupa'an 'emota'sin

"% ?7(?;I(*(I"% ?7(?;I(*(I 7roses melapisi parti'el *)% ?leh *b% 'omp%7roses melapisi parti'el *)% ?leh *b% 'omp%

Complemen+ sh)%lebih mudahcepat difa)osit %Complemen+ sh)%lebih mudahcepat difa)osit %


16/37

*A>IE*(I C?$7=$=;*A>IE*(I C?$7=$=; (istem 'omplemen dpt dia'tif'an mll% .alur :(istem 'omplemen dpt dia'tif'an mll% .alur :

.alur 'lasi' .alur alternatif .alur 'lasi' .alur alternatif Aedua .alur tsb% >er.adi secara beruntunAedua .alur tsb% >er.adi secara beruntun

7rodu' y) timbul pada suatu rea'si a'an merup%7rodu' y) timbul pada suatu rea'si a'an merup%

=n5im untu' rea'si beri'utnya=n5im untu' rea'si beri'utnya

*'tivasi .alur 'lasi' dimulai d)n C1+ sedan)'an*'tivasi .alur 'lasi' dimulai d)n C1+ sedan)'ana'tivasi .alur alternatif dimulai d)n C"%a'tivasi .alur alternatif dimulai d)n C"%

*'tivasi .alur 'lasi' emerlu'an 'omple's *)*b% +*'tivasi .alur 'lasi' emerlu'an 'omple's *)*b% +

sedan)'an .alur alternatif tida'%sedan)'an .alur alternatif tida'%


17/37

>hree pathways for Complementactivation:

• 1% Classical 7athway

• % *lternative 7athway

• "% ectin or $B 7athway

• 7athways for activation reuire multiplesteps cate)ori5ed as:

– 1%


18/37

Ch% 6

p% 16#


19/37

Ch%6

p% 161


20/37

Ch%6


21/37

C1C1

Activated

C4b2b

C3CONVERTASE

C5

C9C8C7C6

Bacterium

IgG

IgM

C4 C

C4a C4bCb Ca

C"

C"aC"b

C4b2b3b

C5 CONVERTASE

Ca CbLysis

MEMBRANEATTACK

COMPLEX

C5-C9

MAC


22/37

Ch%6

p% 16


23/37

Ch%6


24/37

Ch%6


25/37

Ch%6


26/37

Ch%6


27/37

Ch%6

p% 16


28/37

C4b2b

C3CONVERTASE

C5

C9C8C7C6

Bacterium

C4 C

C4a C4bCb Ca

C"

C"aC"b

C4b2b3b

C5 CONVERTASE

Ca CbLysis

MEMBRANEATTACK

COMPLEX

C5-C9

MAC

$*(7

$B


29/37

Ch%6

p% 164


30/37

Late steps of complement activation


31/37

C" C"b

C

C!C6C8C9

Bacterium Factor D

Ba Bb

C"

C"a C"b

C"bBb"b

*lternative Cconvertase

Cb

Ca

ysis

$=$B>*CA

C?$7=G

C5-C9

MAC

Factor B

C"bB C"bBb

*lternative C"convertase

7roperdin

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/mac_flash.htmlhttp://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/mac_flash.html


32/37

Ch%6

p% 181

R l i f l


33/37

Regulatory proteins of complement


34/37

Ch%6

p% 168


35/37

Ch%6


36/37

Ch%6


37/37

comple men

Documents