course contents per week course contents lectures week ... · spectroscopy, fluorimetry 6...

Introduction to Pharmacology (EF1254)

ECTS: 4 4 h/w theory Period: Feb - June

Coordinator: Atilla Akdemir, PhD

Course objective: Providing a basic understanding of pharmacology and its terminology and giving a short introduction to its disciplines. Also, we will discuss several proteins that are important players in pharmacology, such as enzymes and receptors. Course contents: Introduction to pharmacology, research disciplines in pharmacology, pharmacokinetics,

pharmacodynamics, cells, enzymes, receptors (classes, functions, structure), ligands (agonists, inverse agonists, neutral antagonists, allosteric modulators), intracellular signalling pathways. Learning outcomes: The students:

will be able to discuss how drugs act within the body and how they can treat diseases will be able to discuss the most important receptor classes and their signaling cascades

will be able to describe several functional classes of ligands

will be able to describe pharmacokinetics and its importance for medicine Form of tuition: Lectures, tutorials and self-study

Course material: Powerpoint presentations, internet, text book Literature: Rang and Dale’s Pharmacology, International Edition, Seventh Edition, Elsevier Churchill Livingstone

Entry requirements: None

Course contents per week

Course contents – lectures Week Contents

1 General introduction to pharmacology and its disciplines

2 Introduction to proteins as targets for drugs

3 G-protein coupled receptors and intracellular signalling cascades

4 Kinase-linked receptors and intracellular signalling cascades

5 Ion channels

6 Nuclear receptors

7 Calcium as a second messenger

8 Drug absorption and distribution

9 Drug absorption and distribution

10 Drug metabolism and elimination

11 Drug metabolism and elimination

12 Pharmacokinetics

13 Pharmacokinetics

14 Pharmacogenetics, pharmacogenomics and "personalized medicine"

15 Drug discovery and development

Assessment and evaluation system

Mid-term study Number Contribution (%)

Mid-term exam 100

Quiz

Project

Reports

Seminar

Assignments

Presentation

Laboratory

Field work

Total 100

Contribution of mid-term studies to pass mark

40

Contribution of final exam to pass mark

60

Relationship between the learning outcomes of the course and the programme outcomes

No Programme outcomes 1 2 3 4 5

1 The graduates shall know the historical developments, the importance and characteristics of pharmacies in the world and Turkey. The graduates shall know the national and international healthcare related organizations.

x

2 The graduates shall know the ethical and legal principles in the field of pharmacy and pharmaceutical sciences.

x

3 The graduates will be able to communicate health-related subjects and drug-related information to patients, health professionals and other parties.

x

4 The graduates will be able to follow, understand and apply the latest developments in pharmacies and pharmaceutical sciences.

x

5 The graduates will have the administrative and technical proficiencies around the responsibility given by law.

x

6 The graduates will be able to organize pharmacies and other pharmaceutical applications according to the rules.

x

7 The graduates will understand and successfully take part in every stage from design of pharmaceutical products to their marketing.

x

8 The graduates will be able to plan and perform all issues within the pharmaceutical services in the hospital.

x

9 The graduates will have knowledge about the obtainment, production and product technologies and production, obtainment of the natural and chemical pharmaceutical raw materials.

x

10 The graduates will be able to inform patients, their relatives and (patient) organizations in issues according to the safety and quality of natural products.

x

11 The graduates will be able to recognize plants with medical, economic and toxic potential.

x

12 The graduates shall know and will be able to take part in quality assurance. x

13 The graduates shall know and successfully take part in the production and development of the biotechnological and radiopharmaceutical products.

x

14 The graduates will know the drug licensing policies, data protection, and evaluates the relationship between patent issues.

x

15 The graduates shall comprehend the issues of drug recognition, ensuring of drug quality, drug control and standardization.

x

16 The graduates shall know the therapeutic effects of the effective substances of drug and solves problems related to drug such as pharmacokinetic properties and stability

x

17 The graduates will be able to advice on intelligent and safe use of drugs, and they will assist in pharmacovigilance applications.

x

18

The graduates will know the major determinants of the extent and kinetics of drug and drug product instability (e.g., temperature, humidity, light, pH, oxygen, free radicals) and the common types of reactions (and their mechanisms) which influence drug and drug product stability (e.g., hydrolysis, oxidation, cyclization, racemization)

x

19 The graduates will be able to set-up and perform an (scientific) experiment, collect data, evaluate the results and to resolve the problems in the laboratory.

x

20 The graduates will be able to follow and acquire scientific and technological knowledge and improvements

x

21 The graduates will be able to control the physical, chemical, biological, toxicological and pharmaceutical characteristics of nanoformulations.

x

22 The graduates will have knowledge about the mechanism of actions of drugs, their side effects and the benefits of using controlled release and/or nanoformulations to increase the effects of drugs.

x

23 The graduates will become familiar with pharmaceutical data bases and knows how to use them to determine the state of the art of all pharmaceutical technologies.

x

contribution level: 1 (low) – 5 (high)

ECTS – workload table

Activity Number Time (hour) Total workload Class Hours 15 4 60

Other Applications

Final Examinations (including preparatory year) 1 2 2

Quiz

Term Paper/ Project

Portfolio Study

Reports

Learning Diary

Thesis/ Project

Seminar

Other

Working Hours out of Class 15 3 45

Assignments

Presentation

Mid-term Examinations (including time for preparation)

Project

Clinical Practice

Laboratory

Field Work

Total Workload 107

Total Workload / 25 4.28

ECTS Credit of Course 4

Second year courses

Analytical Chemistry II (EF2151)

ECTS: 6 3 h/w theory; 4 h/w practice Period: Sep - Jan

Coordinator: Evrim TEKKELİ, PhD

Course objective:

Providing current and detailed information about the instrumental techniques that are

especially used for drug, metabolite analysis. In this way the students will get the ability

to design and develop new analytical methods according to the type, properties of

analytes and their matrices.

Course contents:

Introduction to instrumental analytical methods, optical and spectroscopic techniques,

atomic spectroscopy (atomic absorption and fluorescence spectroscopy, atomic emission

spectroscopy, atomic mass spectroscopy), molecular spectroscopy (UV, VIS, molecular

luminescence spectroscopy, infrared spectroscopy, raman spectroscopy, nuclear

magnetic resonance spectroscopy, mass spectrometry), Electrochemistry and

electrochemical analysis, electrometric methods (coulometry, conductometry,

voltammetry, potentiometry), chromatographic methods (liquid chromatography, gas

chromatography, supercritical liquid chromatography and other modern chromatographic

techniques), electrophoresis, automated analytical techniques, the use of instrumental

analysis in the studies of bioequivalence and bioavailability and drug analyses.

Learning outcomes:

The students:

• will be able to understand techniques of an instrumental analysis

• will be able to analyze analytes in different matrices

• will be able to describe biological fluids, pharmacokinetics and monitorizing a

drug substance after administration

Form of tuition:

Lectures, tutorials and self-study

Course material:

Powerpoint presentations, videos

Literature:

Instrumental analysis, Skoog

Entry requirements:

None


Course contents – lectures

Week Contents

1 Introduction to instrumental techniques

2 Optical and spectroscopic techniques

3 Atomic spectroscopy (atomic absorption and fluorescence spectroscopy, atomic emission spectroscopy, atomic mass spectroscopy)

4 Molecular spectroscopy (UV, VIS spectrometry)

5 Introduction to molecular luminescence spectroscopy, fluorimetry

6 Fluorimetry, phosphorimetry,chemiluminescence

7 Infrared spectroscopy, raman spectroscopy

8 Nuclear magnetic resonance spectroscopy, mass spectrometry

9 Introduction to electrochemical analysis and electrometric methods, culometry, conductometry

10 Voltammetry, potentiometry

11 General principles of chromatography

12 HPLC

13 GC

14 SFC and capillary electrophoresis

15

Micellary electrokinetic chromatography, application of instrumental analysis in bioequivalence, bioavailability studies, drug analyses

Course contents – practical courses

Week Contents

1 ____

2 ____

3 Some experiments to remind analytical chemistry 1

4 Spectrophotometric drug analysis

5 Spectrophotometric analysis

6 Spectrofluorimetric drug analysis

7 -------

8 HPLC study for drug analysis form pharmaceutical preparations

9 HPLC study for drug analysis from pharmaceutical preparations

10 HPLC study for drug analysis from biological fluids


12 UPLC study for drug analysis from pharmaceutical preparations

13 UPLC study for drug analysis from biological fluids

14 Literature survey for chromatographic analysis

15 Presentations about chromatographic drug analysis



Mid-term exam 1 100

Quiz 2 10

Project --- ---

Reports --- ---

Seminar --- ---

Assignments ---

Presentation 1 5

Laboratory 13 ---

Field work --- ---

Total --- ---


40


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x




Other Applications


Quiz 2 2.5 5

Term Paper/ Project

Portfolio Study

Reports 2 3 6

Learning Diary

Thesis/ Project

Seminar

Other


Assignments

Presentation 1 5 5


1 6 6

Project 1 5 5

Clinical Practice

Laboratory 12 4 48

Field Work

Total Workload 150

Total Workload / 25 6


Organic Chemistry (EF2156)

ECTS: 4 4 h/w theory Period: Sep - Jan

Coordinator: Binnur Temel, PhD

Course objective:

The course focuses on the properties and reactions of common classes of organic

compounds; the relationship between the structures of organic compounds and their

physical and chemical properties. Some reaction mechanisms are also covered.

Course contents:

Introduction to organic chemistry, orbitals and covalent bonds, structural isomers and

nomenclature. Chemical characteristics of alkanes, alkenes, alkynes, aromaticity and

benzene, alkyl halogens, alcohols, ethers, epoxides, thiols, aldehydes, ketones,

carboxylic acids and their derivatives, amines and amides, and their synthesis. Acidity

and basicity of organic compounds, and stereochemistry. Chemical reactions, basic

chemical reactions with mechanisms (substitutions, eliminations, free radical reactions,

etc.).

Learning outcomes:

Students will recognize the inherent properties of organic compounds, can systematically

name the structures, understand the mechanisms of reactions and gain the ability to

correlate this information with other disciplines.

Form of tuition:


Course material:

PowerPoint presentations, text book and internet

Literature:

Organic Chemistry, 3rd Edition by Janice Gorzynski Smith, McGraw-Hill

Organic Chemistry, 6th Edition by L. G. Wade, Jr., Pearson PrenticeHall

Entry requirements:

None



Week Contents

1 Structure and Bonding

2 Acids and Bases

3 Alkanes

4 Stereochemistry

5 Understanding Organic Reactions

6 Alkyl Halides

7 Alcohols, Ethers and Epoxides

8 Alkenes and Alkynes

9 Conjugation, Resonance and Dienes

10 Benzene and Aromatic Compounds

11 Carboxylic Acids and Their Derivatives

12 Amines

13 Carbohydrates

14 Amino Acids and Proteins

15 Lipids


Week Contents

1

2

3

4



Mid-term exam 1 80

Quiz 2 5

Project - -

Reports - -

Seminar - -

Assignments - -

Presentation - -

Laboratory - -

Field work - -

Total 3 100

Contribution of mid-term

studies to pass mark

(%)

- 40

Contribution of final

exam to pass mark (%)

- 60

Total 100














12 The graduates shall know and will be able to take part in quality assurance.






18









Activity Number Time (hour) Total workload

Class Hours 15 4 60

Other Applications 0 0 0

Mid-term Examinations (including time for

preparation) 1 5 5

Quiz 2 2 4

Term Paper/ Project 0 0 0

Portfolio Study 0 0 0

Reports 0 0 0

Learning Diary 0 0 0

Thesis/ Project 0 0 0

Seminar 0 0 0

Other 0 0 0


Assignments 0 0 0

Presentation 0 0 0

Final Examinations (including preparatory

year) 1 10 10

Project 0 0 0

Clinical Practice 0 0 0

Laboratory 0 0 0

Field Work 0 0 0

Total Workload 111



Pharmacology I (EF2254)



Course objective: We will deepen our knowledge of the important proteins (such as enzymes and receptors) and pharmacokinetics and pharmacodynamics. We will discuss several mechanisms of important diseases. Course contents: G-protein coupled receptors; ligand-gated ion channels; voltage-gated ion channels; receptor

tyrosine kinases; nuclear receptors; enzymes, intracellular signaling pathways; membrane potential; action potential generation and propagation; muscle contraction (smooth, heart, muscle); neurotransmission; autonomic nervous system; parasympathetic nervous system; sympathetic nervous system; neurotransmitter release; cholinergic system; noradrenergic system Learning outcomes: The students:

will be able to discuss the structure, function and signaling cascades linked to GPCRs,

LGICs, VGICs, RTKs, NRs and enzymes will be able to discuss the functioning of excitable cells and muscle cells will be able to discuss the functioning of the autonomous nervous system will be able to discuss the cholinergic and noradrenergic systems will be able to discuss the serotoninergic, histaminergic systems

will be able to discuss NO, cannabinoids, purines and cytokines related signaling Form of tuition: Lectures, tutorials and self-study Course material: Powerpoint presentations, internet, text book

Literature: Rang and Dale’s Pharmacology, International Edition, Seventh Edition, Elsevier Churchill Livingstone

Entry requirements: EF1254



1 Receptors and enzymes as drug targets

2 Chemical mediators and the autonomous nervous system

3 Cholinergic transmission

4 Cholinergic transmission

5 Noradrenergic transmission

6 Noradrenergic transmission

7 Serotoninergic transmission

8 Serotoninergic transmission

9 Histaminergic transmission

10 Histaminergic transmission

11 Nitric oxide as a messenger

12 Nitric oxide as a messenger

13 Cannabinoids

14 Purines

15 Cytokines



Quiz

Project

Reports

Seminar

Assignments

Presentation

Laboratory

Field work

Total


40


60




x


X


X


X


X


X


X


X


X


X


X

12 The graduates shall know and will be able to take part in quality assurance. X


X


X


X


x


X

18


X


X


X


X


X


x




Other Applications


Quiz

Term Paper/ Project

Portfolio Study

Reports

Learning Diary

Thesis/ Project

Seminar

Other


Assignments

Presentation


1 10 10

Project

Clinical Practice

Laboratory

Field Work

Total Workload 102



Introduction to Pharmaceutical Technology (EF2258)


Coordinator: Fatemeh Bahadori, PhD

Course objective:

At the end of this course, students will know the basic calculations in Pharmaceutical

Technology, applications and techniques.

Course contents:

Definition of drugs and the introduction of application forms, the basic calculations used

in pharmaceutical technology, processes and techniques, drug-related phase diagrams,

solubility, solutions, physical and kinetic etc. properties. Distilled water and preparation

methods for pharmaceutical purposes.

Learning outcomes:

To train students who are aware of the technologies which are used in pharmaceutical

and scientific developments and to teach them how to combine the knowledge obtained

from literature with laboratory experience and apply it to industry. To teach the basic

rules of pre formulations and to make sure that the graduates will be aware of safety

rules for human health and the environment during research and industrial applications.

Form of tuition:

Lectures, tutorials, self-study

Course material:

Powerpoint presentations

Literature:

An introduction to pharmaceutical formulation, A. G. Fishburn

Pharmaceutical Biotechnology:An Introduction for Pharmacists and Pharmaceutical

Scientists, Daan J. A. Crommelin, Robert D. Sindelar

Modern Farmasötik Teknoloji, TEB Eczacılık Akademisi

Entry requirements:

None



Week Contents

1 Definition of Pharm. Tech. Definition of drug, information about the codex and pharmacopoeia

2 The classification of drugs according to their formulations, applications and usage.

3 The classification of drugs according to their formulations, applications and usage.

4 Introduction to Pre-formulation

5 Definition of pre-formulation

6 Tests related to pre-formulation and the benefits of pre-formulation

7 Solvents and drugs in solvent forms

8 Semi-solid drugs, ointments and pomades,

creams, gels and colloidal systems.

9 Semi-solid drugs, enema and its applications

10 The basic procedures in drug production, drying, weighing, distillation

11 The basic procedures in drug production, mixing, sieving and filtration

12 The basic procedures in drug production, extraction, drugs produced by extraction

13 Information about prescription and prescription interpretation

14 Drug delivery systems

15 Nano- drug delivery systems


Week Contents

1



Mid-term exam 1 50

Quiz 2 40

Project - -

Reports - -

Seminar - -

Assignments 2 10

Presentation - -

Laboratory - -

Field work - -

Total 5 100



(%)

- 40



- 60

Total 100




X


X


X


X


X


X


X


X


X


X


X



X


X


X


X


X

18


X


X


X


X


X


X




Class Hours 15 2 30



preparation) 1 5 5

Quiz 2 3 6



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 2 2 4

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 0 0 0

Field Work 0 0 0

Total Workload 76

Total Workload / 25 3,04


Third year courses

Pharmacology II (EF3154)



Course objective: Providing a basic understanding of important diseases and the mechanisms of actions of selected drugs. Course contents: Pathophysiology of important diseases and action mechanisms of applied drugs: cancer, inflammation, neurological disorders, cardiovascular disorders, viral and bacterial infections, HIV

and AIDS. Drugs that are active in the immune system, histamine and antihistaminic drugs. Learning outcomes: The students:

will be able to discuss the cardiovascular system, the diseases that occur and the drugs that exists

will be able to discuss anti-inflammatory and immunosuppressant drugs

will be able to discuss neurodegenerative diseases and the existing drug treatments will be able to discuss general anaesthetic agents will be able to discuss diabetus and the existing drug treatments will be able to discuss cancer and aids the existing drug treatments

Form of tuition: Lectures, tutorials and self-study Course material: Powerpoint presentations, internet, text book Literature:

Rang and Dale’s Pharmacology, International Edition, Seventh Edition, Elsevier Churchill Livingstone




1 Cardiovascular system

2 Cardiovascular system

3 Atherosclerosis and lipoprotein metabolism

4 Atherosclerosis and lipoprotein metabolism

5 Anti-inflammatory and immunosuppressant drugs

6 Anti-inflammatory and immunosuppressant drugs

7 The control of blood glucose and drug treatment of diabetus mellitus

8 The nervous system

9 Neurodegenerative diseases

10 Neurodegenerative diseases

11 General anaesthetic agents

12 Cancer

13 Cancer

14 AIDS

15 AIDS



Quiz

Project

Reports

Seminar

Assignments

Presentation

Laboratory

Field work

Total


40


60




X


X


X


X


X


X


X


X


X


X


X



X


X


X


X


X

18


X


X


X


X


X


x




Other Applications


Quiz

Term Paper/ Project

Portfolio Study

Reports

Learning Diary

Thesis/ Project

Seminar

Other


Assignments

Presentation


1 10 10

Project

Clinical Practice

Laboratory

Field Work

Total Workload 102



Pharmaceutical Technology I (EF3158)



Course objective:

Students will learn about semi solid dosages, double phase systems and their functions

Course contents:

Preparation and usage of aromatic waters and syrups; potions, lemonades, merlits,

elixirs, the solutions that don’t have water as the major solute (syrup, potion, glyceres,

collutuars, lotions and enema), water (distilled and deionized water), solution (solubility

conditions and kinetics), and rheology, aerosols, macromolecules, colloids, suspensions,

emulsions.

Learning outcomes:


and scientific developments specially the semi-solid and colloidal ones and to teach them

how to combine the knowledge obtained from literature with laboratory experience and

apply it to the development of semi-solid formulations.

Form of tuition:


Course material:


Literature:

Current Research in Pharmaceutical Technology, Sabine Globig,William Hunter, Jr

Experimental pharmaceutical technology, Eugene L. Parrott, Witold Saski




Entry requirements:

EF 2258



Week Contents

1 Definition of standards, preparation of standards and harmonize them with the current rules

2 Definition of pharmaceutical water forms and its key role in pharmaceutical applications. Preparation of distilled water, introduction of water reservoirs and its delivery systems.

Validation methods of water systems and definition of quality control methods of

pharmaceutical waters.

3 The discussion of the dosage forms together with their applications and the resulted therapeutic effects. Application of physicochemical and biopharmaceutical rules to dosage forms.

4 Biopharmaceutical evaluations of pharmaceutical dosage forms and their

applications in design of different dosage forms

5 Definition of solutions, introduction to the solutions available in the market, advantage and dis-advantages of solution forms, definition of aqueous and dry dosage forms

6 Methods used in preparation of solutions, quality control and stability tests for solutions. Preparation of solutions and their labelling

7 The theory of disperse systems, intra-face circumstances, the electro-kinetic and rheological specifications of colloidal and rough dispersions. Definition of colloidal systems and intra-face events and their application to pharmaceutical productions.

8 Explanation of physical characteristics of suspensions, definition of flocculation and aggregation. The effects of viscosity on the sedimentation of suspensions.

9 Definition of emulsions and emulsion makers. The two most important factors in in definition of emulsion types; (o/w vs. w/o).

10 Definition of the instability levels related to emulsions. The methods for stabilizing the emulsions. The HLB (Hydrophilic, Lipophilic Balance) calculations for emulsions.

11 The classification of ointment based drug dosages. Their physical properties and the best usage form definitions

12 Integration of the solid drugs to the ointment bases and their different applications. The relation between the ointment ingredients and the release period.

13 The definition of suppositories, explanation of their size and applications, advantage and dis-advantages and related ingredients. Packing and storage conditions, quality control tests and the suggestions for patient for maximum efficacy

14 Definition of aerosols, their ingredients and their advantage and disadvantages. Definition of container, valve, propellant and product concentration which is used inn production of aerosols. Packing, storage and usage conditions.

15 Transdermal dosage forms, transdermal patch systems, their ingredients, advantages and dis advantages.


Week Contents

1 Preparation of topical solvent formulations

2 Preparation of topical solvent formulations

3 Preparing syrup formulations in small scale

4 Preparing syrup formulations in small scale

5 Preparation of topical suspensions and their labelling

6 Investigation of the rheological properties of the suspensions

7 Preparation of oral suspensions and their labelling

8 The methods used in preparation of emulsions

9 The methods used in preparation of ointments

10 The methods used in preparation of ointments

11 Preparation of suppositories

12 Stability tests

13 Stability tests

14 Make up

15 Make up



Mid-term exam 1 50

Quiz - -

Project - -

Reports - -

Seminar - -

Assignments - -

Presentation - -

Laboratory 2 25

Field work - -

Total 3 100



(%)

- 40



- 60

Total - 100




X


X


X


X


X


X


X


X


X


X


X



X


X


X


X


X

18


X


X


X


X


X


X




Class Hours 15 3 45



preparation) 1 5 5

Quiz 0 0 0



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 0 0 0

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 15 2 30

Field Work 0 0 0

Total Workload 111



Pharmaceutical Chemistry I (EF3161)



Course objective:

At the end of this course, the students should be able to: a) detect the relationship

between physicochemical properties and activity of different drugs, b) understand how

drugs function on the molecular level (mechanism of action), c) study the concepts of

drug latentiation and pro-drug formation, d) know some drug classes including

preparation, identity assay procedures, e) qualitatively analyse some of the studied

pharmaceutical substances, and f) perform different chemical limit tests according to

pharmacopeia requirements.

Course contents:

Factors that affect drug activities, physicochemical factors (solubility, ionization and

steric factors), chemical properties, chemical bonds, structural characteristics,

contribution of some functional groups to the biological effects, definition of isoster and

bioisosterism.

Learning outcomes:

To prepare students who are aware of the pharmaceutical and scientific developments in

related fields and will combine knowledge and creativity gained in education, to

contribute to the academia, community or industry. To provide the students with the

skills needed for the synthesis and purification of organic molecules in the laboratory. To

teach strict rules which to ensure conditions are safe for human health and the

environment during these applications.

Form of tuition:

Lectures, tutorials, laboratory and self-study

Course material:


Literature:

Medicinal Chemistry An Introduction, 2nd Edition by Gareth Thomas

Medicinal Chemistry, A Biochemical Approach, T.Nogrady

An Introduction to Medicinal Chemistry, G.L.Patrick

Foye’s Principle of Medicinal Chemistry, D.A.Williams, T.L.Lemke

Textbook of Organic Medicinal and Pharmaceutical Chemistry, J.N.Delgado, W.A.Remers

The Practice of Medicinal Chemistry, C.G.Wermuth

Entry requirements:

None



Week Contents

1 Pharmaceutical chemistry within the

framework of pharmacy education, sources

of drugs

2 Drug development, structure-activity

relationships, isosterism

3 Bioisosterism, factors effecting biological

activity,protein binding,solubility, patition

coefficient, acids and bases

4 Ionization constant (pKa), Handerson -

Hasselbach equation, inductive and

resonance effects

5 Electronic substituent constant,Hammet

equation, reaction constant

6 Quantitative structure activity relations,

interpretation of the equations,

7 Biological membranes, drug targets,

receptor types

8 Bonds in drug receptor interactions,

covalent bonds

9 Isomerism in drug receptor interactions,

enzymes

10 Nucleic acids,the chemistry of drug

metabolism and excretion, phase I

reactions

11 Oxidation, reduction, hydrolysis

12 Prodrugs,hard and soft drugs

13 Antibacterial agents

14 The peripheral nervous system-

cholinergics, anticholinergics, and

anticholineesterases

15 The peripheral nervous system-

cholinergics, anticholinergics, and

anticholineesterases


Week Contents

1 Physical and chemical methods in drug

synthesis

2 Physical and chemical methods in drug

synthesis

3 Distillation, extraction,

recrystallization,filtration

4 Distillation, extraction,

recrystallization,filtration

5 Nitration,halogenation,diazotization,

acylation, condensation,reduction,

oxidation,esterification, hydrolysis

























14 Make-up

15 Make-up



Mid-term exam 1 55

Quiz - -

Project - -

Reports - -

Seminar - -

Assignments - -

Presentation - -

Laboratory 9 5

Field work - -

Total 3 100



(%)

- 40



- 60

Total 100

Relationship between the learning outcomes of the course and the programme

outcomes


1

The graduates shall know the historical developments, the

importance and characteristics of pharmacies in the world and

Turkey. The graduates shall know the national and international

healthcare related organizations.

2 The graduates shall know the ethical and legal principles in the field

of pharmacy and pharmaceutical sciences.

3

The graduates will be able to communicate health-related subjects

and drug-related information to patients, health professionals and

other parties.

4 The graduates will be able to follow, understand and apply the

latest developments in pharmacies and pharmaceutical sciences.

5 The graduates will have the administrative and technical

proficiencies around the responsibility given by law.

6 The graduates will be able to organize pharmacies and other

pharmaceutical applications according to the rules.

7 The graduates will understand and successfully take part in every

stage from design of pharmaceutical products to their marketing.

8 The graduates will be able to plan and perform all issues within the

pharmaceutical services in the hospital.

9

The graduates will have knowledge about the obtainment,

production and product technologies and production, obtainment of

the natural and chemical pharmaceutical raw materials.

10

The graduates will be able to inform patients, their relatives and

(patient) organizations in issues according to the safety and quality

of natural products.

11 The graduates will be able to recognize plants with medical,

economic and toxic potential.

12 The graduates shall know and will be able to take part in quality

assurance.

13

The graduates shall know and successfully take part in the

production and development of the biotechnological and

radiopharmaceutical products.

14 The graduates will know the drug licensing policies, data protection,

and evaluates the relationship between patent issues.

15 The graduates shall comprehend the issues of drug recognition,

ensuring of drug quality, drug control and standardization.

16

The graduates shall know the therapeutic effects of the effective

substances of drug and solves problems related to drug such as

pharmacokinetic properties and stability

17 The graduates will be able to advice on intelligent and safe use of

drugs, and they will assist in pharmacovigilance applications.

18

The graduates will know the major determinants of the extent and

kinetics of drug and drug product instability (e.g., temperature,

humidity, light, pH, oxygen, free radicals) and the common types of

reactions (and their mechanisms) which influence drug and drug

product stability (e.g., hydrolysis, oxidation, cyclization,

racemization)

19

The graduates will be able to set-up and perform an (scientific)

experiment, collect data, evaluate the results and to resolve the

problems in the laboratory.

20 The graduates will be able to follow and acquire scientific and

technological knowledge and improvements

21 The graduates will be able to control the physical, chemical,

biological, toxicological and pharmaceutical characteristics of

nanoformulations.

22

The graduates will have knowledge about the mechanism of actions

of drugs, their side effects and the benefits of using controlled

release and/or nanoformulations to increase the effects of drugs.

23

The graduates will become familiar with pharmaceutical data bases

and knows how to use them to determine the state of the art of all

pharmaceutical technologies.




Class Hours 15 3 45



preparation) 1 5 5

Quiz 0 0 0



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 0 0 0

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 15 2 30

Field Work 0 0 0

Total Workload 111



Pharmaceutical Technology II (EF3258)

ECTS: 4 3 h/w theory; 2 h/w practice Period: Feb - June


Course objective:

The aim of this course is to understand the applications of Pharmaceutical technology in

the areas rather than medicine preparation such as preparation of hygiene products

Course contents:

Preparation of pharmaceuticals, physical, chemical and microbiological controls, in vivo

and in vitro experiments, suppository (general information and control of ointments,

preparation and control of suppositories), preparation of ovules, surgical materials

(gauze, cotton, plaster, etc.), paste, tooth paste, soap, radiopharmaceuticals, colorants

and antioxidants, parenteral solutions, ophtalmologic preparations (preparation and

sterilization of eye drops).

Learning outcomes:


procedures like sterilization. To teach them how to apply pharmaceutical sciences to

areas other than pharmacy practice

Form of tuition:


Course material:


Literature:

Current Research in Pharmaceutical Technology, Sabine Globig,William Hunter, Jr

Experimental pharmaceutical technology, Eugene L. Parrott, Witold Saski




Entry requirements:

None



Week Contents

1 isotonicity calculations and preparation of ophthalmic propagates. Tampons, tampon

capacity, isoosmotics, isoosmotic pressure and definition of hypertonicity and hypotonicity. The

pH area acceptable for ophthalmic solutions.

2 Tampons are used in preparation of ophthalmological solutions with the desired pH

and isotonicity, the importance of isotonicity in the ophthalmic preparations.

3 Preparation of nasal and otic preparations, the importance of sterilization in the preparation of otic and nasal formulations

4 Explanation of microbial contamination sources, introduction of the methods used in minimising

the microbial contaminations, microbial quality controls, disinfectants. Antiseptic applications and sterilization, the efficacy tests for the protectants. Sterilization methods, autoclaves, dry air sterilizations.

5 Sterilization by radiation, sterilization via filtration, sterilization by chemical methods. To select the best sterilization method. The safety of sterilization method, the sterilized dosages used in pharmacology.

6 A short history of parenteral preparations, parenteral application methods, production techniques and the necessary aseptic techniques. The calculations related to parenteral preparations.

7 The explanations about the decision procedure need to be done for parenteral dosages, the clean room definitions and the quantification tests like pyrogen test, clarity test and particle analysis

8 Parenteral solvents in bulk volumes, total parenteral feeding, irrigation solvents

9 Pharmaceutical powders, particle properties, the properties of powders and granules and the best ways of their applications

10 The advantages and disadvantages of tablets. The crucial USP tests for tablets and evaluation of tablets according to these results.

11 evaluation of tablets according to USP results.

12 Evaluation of tablets according to pharmacopeia

13 Advantage and disadvantages of capsules. The crucial USP tests for capsules. The methods for preparation of soft and hard capsules. Evaluation of capsules according to pharmacopeia

14 Some samples of hard and soft pastilles

15 Packing, primer and seconder packing, the importance of packing, the factors influence the selection of packing, the materials are used in different package forms.


Week Contents

1 Preparation of ophthalmic and nasal formulations



4 Preparation of sterilized parenteral formulations

5 Preparation of sterilized parenteral formulations

6 Sterilization techniques

7 Preparation of parenteral formulations in bulk volume

8 Preparation of powders, granules and effervescent tablets

9 Preparation of tablet formulations

10 Quality control of tablet formulations

11 Preparation of capsule formulations

12 Quality control of capsule formulations

13 Preparation of soft and hard pastilles

14 Make up

15 Make up



Mid-term exam 1 50

Quiz - -

Project - -

Reports - -

Seminar - -

Assignments - -

Presentation - -

Laboratory 2 25

Field work - -

Total 3 100



(%)

- 40



- 60

Total - 100




X


X


X


X


X


X


X


X


X


X


X



X


X


X


X


X

18


X


X


X


X


X


X




Class Hours 15 3 45



preparation) 1 5 5

Quiz 0 0 0



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 0 0 0

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 15 2 30

Field Work 0 0 0

Total Workload 111



Pharmaceutical Chemistry II (EF3261)

ECTS: 4 3 h/w theory; 2 h/w practice Period: Period: Sep - Jan


Course objective:

The objective of this course is to prepare the student for professional practice by

teaching the sources, nature, uses, and important chemical, biochemical and

pharmacological aspects of medicinal and pharmaceutical agents that treat or alleviate

the disorder and regain the proper function different systems of the human body.

Course contents:

Chemical properties, synthetic routes and metabolism, structure-activity relationships

of: Histamine and antihistamines, local anesthetics, analgesics and drugs acting on the

peripheral nervous system drugs (cholinergic, anticholinergic agents, adrenergics).

Drugs that affect the digestive system (emetics and anti-emetics, gastric acid-enhancing

drugs, anti-acid and medicines to prevent gastric secretion, drugs used to treat liver

disorders, cholagogues, laxative, antidiaretic drugs, endocrine system drugs, steroidal

hormones and diagnostic drugs. Antibacterial drugs (sulfonamides, urinary antibacterial

agents, antibiotics), antihelmentic and antifungal drugs, anticoagulant drugs, antitussive

drugs and anticancer drugs.

Learning outcomes:

Upon successful completion of this course the students can now understand the recent

advances in the medicinal chemistry and drug design together with the synthesis and

pharmacological profile of some selected classes of pharmaceutical agents.

Form of tuition:

Lectures, tutorials, laboratory and self-study

Course material:


Literature:

Medicinal Chemistry An Introduction, 2nd Edition by Gareth Thomas

Medicinal Chemistry, A Biochemical Approach, T.Nogrady

An Introduction to Medicinal Chemistry, G.L.Patrick

Foye’s Principle of Medicinal Chemistry, D.A.Williams, T.L.Lemke

Textbook of Organic Medicinal and Pharmaceutical Chemistry, J.N.Delgado, W.A.Remers

The Practice of Medicinal Chemistry, C.G.Wermuth

Entry requirements:

None



Week Contents

1 Sympathetic (adrenergic) system,

adrenergic agonists

2 Antihypertensive drugs,antiarrythmic and

antihyperlipidemic drugs

3 Drugs acting on coagulation mechanisms,

diuretics,antiparkisonian drugs

4 Muscle relaxants, drugs acting on the

gastro-intestinal system

5 General anesthetics,local anesthetics

6 Sedatives and hypnotics, antiepileptics

7 Antidepressants, psychoanaleptics

8 Psychoactive drugs, neuroleptics

9 Histamine and antihistaminic drugs,H1-

receptor antagonists

10 H2-receptor antagonists ,proton pump

inhibitors and inhibitors of histamine

release

11 Morphine and narcotic analgesics

12 Thyroid hormones and related drugs

13 Beta-lactam antibiotics, penicillins

14 Antifungal and antiviral drugs

15 Anticancer drugs


Week Contents

1 Qualitative chemical and spectral analysis

of organic compounds

2 Structure determination in organic

compounds

3 Determination of elemental composition

and solubility

4 Melting point determination

5 Functional group identification

6 UV and IR spectroscopy in structure

determination

7 Analysis of NMR and mass spectra

8 Structure determination of an unknown

using chemical and spectral methods











14 Make-up

15 Make-up



Mid-term exam 1 55

Quiz - -

Project - -

Reports - -

Seminar - -

Assignments - -

Presentation - -

Laboratory 9 5

Field work - -

Total 3 100



(%)

- 40



- 60

Total 100


outcomes


1







3



other parties.











9




10







assurance.

13








16






18






racemization)

19








nanoformulations.

22




23







Class Hours 15 3 45



preparation) 1 5 5

Quiz 0 0 0



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 0 0 0

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 15 2 30

Field Work 0 0 0

Total Workload 111



Fourth year courses

Drug Design and Structure-Activity Relationships (EF4168)



Course objective: Providing a basic understanding of drug design and development in general. Also, we will discuss computer-aided drug design and discovery procedures and SAR methods. Course contents: Introduction to drug development: target identification, target validation, hit identification, lead identification and optimization, preclinical studies, clinical studies, drug approval, marketing;

introduction to structure-activity relationships; methods for rational and computer-aided drug design and discovery; interactions between drug active substance and receptor/enzyme; sequence alignments; molecular modeling, homology models, docking, structure-based design procedures, ligand-based design procedures. Learning outcomes:

The students:

will be able to discuss the general features of drug development will be able to discuss the characteristics of a good target for drug development will be able to discuss the different procedures used for rational and computer-aided drug

design and discovery Form of tuition:

Lectures, tutorials and self-study Course material: Powerpoint presentations, internet Literature: --




1 Introduction to drug development

2 Target identification/validation – hit finding – lead finding/optimization

3 protein structures

4 structure-activity relationships

5 structure-activity relationships

6 ligand-protein interactions

7 homology modelling

8 docking

9 QSAR

10 literature project

11 literature project 12 literature project 13 literature project 14 literature project 15 presentation



Quiz

Project 1 40

Reports

Seminar

Assignments

Presentation

Laboratory

Field work

Total 40


-


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x




Other Applications


Quiz

Term Paper/ Project

Portfolio Study

Reports

Learning Diary


Seminar

Other


Assignments

Presentation 1 1 1


Project

Clinical Practice

Laboratory

Field Work

Total Workload 139



Optional lectures (during the third and fourth year)

Introduction to Polymer Chemistry (EF3302)

ECTS: 2 2 h/w theory Period: to be announced


Course objective:

Providing a basic understanding of the chemistry of organic, inorganic, and biopolymers,

with an emphasis on synthesis, mechanism, and reaction kinetics. Modern methods of

polymer characterization will be also discussed.

Course contents:

History of polymers, fundamental concepts in polymer science (classification, molecular

weight, glass transition temperature and melting point etc.), polymerization techniques

and mechanisms, thermal and mechanical properties of polymers, natural and synthetic

polymers and applications of polymers in pharmacy.

Learning outcomes:

Students will recognize the importance of organic chemistry on the daily life and

industry and will learn the basic topics of polymer chemistry.

Form of tuition:


Course material:


Literature:

Polymer Synthesis, P.Remp, Merril

Principles of Polymerization, 4th Edition by George Odian

Polymer Chemistry: An Introduction, 3rd Edition by Malcolm P. Stevens

Principles of Polymer Chemistry by Paul J. Flory

Textbook of Polymer Chemistry by Fred W. Billmeyer

Entry requirements:

None



Week Contents

1 History of Macromolecular Science

2 Concept of Macromolecules

3 Basic Concepts in Polymer Science

4 Chemical Bonding in Polymers

5 Stereochemistry of Polymers

6 Monomer Structure and Polymerizability

7 Polymerization Methods



10 Concept of Crystallization in Polymers

11 Polymer Characterization

12 Polymer Characterization

13 Reactions on Polymers

14 Natural Polymers

15 Natural Polymers


Week Contents

1

2

3

4



Mid-term exam 1 100

Quiz - -

Project - -

Reports - -

Seminar - -

Assignments - -

Presentation - -

Laboratory - -

Field work - -

Total 1 100



(%)

- 40



- 60

Total 100


outcomes


1







3



other parties.











9




10







assurance.

13








16






18






racemization)

19








nanoformulations.

22




23







Class Hours 15 2 30



preparation) 1 5 5

Quiz 0 0 0



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 0 0 0

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 0 0 0

Field Work 0 0 0

Total Workload 61



Synthetic Organic Chemistry (EF3303)



Course objective:

Providing a basic understanding of structure, reactivity and synthesis of biologically

important molecules. Particular emphasis is placed on carbohydrates, amino acids,

peptides, proteins, lipids, and nucleic acids. An introduction to the organic chemistry of

metabolism is given. Also, pericyclic reactions will be discussed.

Course contents:

Basic synthesis methods for a compound which has pharmaceutical importance,

functional group transformation and stereochemical synthesis strategies, planning the

synthesis of targeting molecule, total synthesis, retrosynthetic analysis and strategies,

several synthesis examples.

Learning outcomes:

Students will have knowledge about:

- base of synthetic organic chemistry reactions

- structure-reactivity principles in a variety of chemical structures

Students will be able to:

- to devise synthetic strategies to complex molecule construction

- develop fundamental critical thinking skills, including pattern recognition and

analogous reasoning

Form of tuition:


Course material:


Literature:

Advanced Organic Chemistry, Part B: Reactions and Synthesis, 5th edition (2008) by

Francis A. Carey and Richard J. Sundberg

Advanced Organic Chemistry, M. Smith and J. March

Comprehensive Organic Transformations , R. C. Larock

Entry requirements:

None



Week Contents

1 What is Organic Synthesis?



4 Synthesis of alkynes by alkylations

5 Synthesis of alkynes by Pd-catalyzed

reactions

6 Synthesis of alkenes and substituted

arenes

7 Synthesis of alkenes and substituted

arenes

8 Functional group manipulation

9 Functional group manipulation

10 Carbonyl chemistry



13 Pericyclic reactions




Week Contents

1

2

3

4



Mid-term exam 1 90

Quiz - -

Project - -

Reports - -

Seminar - -

Assignments 1 10

Presentation - -

Laboratory - -

Field work - -

Total 2 100



(%)

- 40



- 60

Total 100


outcomes


1







3



other parties.











9




10







assurance.

13








16






18






racemization)

19








nanoformulations.

22




23







Class Hours 15 3 45



preparation) 1 5 5

Quiz 0 0 0



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 1 3 3

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 0 0 0

Field Work 0 0 0

Total Workload 87



Synthesis and Preparation of New Drug Delivery Systems (EF3305)


Coordinators: Binnur Temel, PhD & Fatemeh Bahadori, PhD

Course objective:

Students will understand the differences between Controlled Release Drug Delivery

Systems and classic drugs and will become familiar with nano-scaled drugs

Course contents:

Fundamental concepts in controlled drug delivery systems, function and preparation of

drug delivery systems, colloidal drug delivery systems, micro and nanoparticle systems,

drug targeting, design, synthesis and preparation of new carrier systems, use of

nanotechnology in drug delivery systems, protein carrier and bioadhesive systems.

Learning outcomes:

Students will have knowledge about:

- types of new drug delivery systems

- their preparation techniques

- recent developments

Form of tuition:


Course material:


Literature:

Drug Delivery Systems, J.R.Juliano, Oxford University Press

Controlled Drug Delivery, J.R.Robinson and Vincent H.L. Lee, Drugs and Pharm. Sci.

Series, Vol. 29, Marcel Dekker Inc.

Novel Drug Delivery Systems, Yie W. Chien, Drugs and Pharm. Sci. Series, Vol.14,

Marcel Dekker Inc.N.Y.

Sustained and Controlled Release Drug Delivery Systems, Joseph R. Robinson, Drugs &

Pharm. Sci. Series, Vol. 6 Marcel Inc.,N.Y.

Polymers in Controlled Drug Ddelivery, Lisbeth, llum & Stanley S. Davis.

Entry requirements:

None



Week Contents

1 Theory of controlled release drug delivery

systems

2 Theory of controlled release drug delivery

systems

3 Microencapsulation

4 Microencapsulation

5 Transdermal drug delivery systems

6 Implants and Inserts

7 Targetted drug delivery systems

8 Targetted drug delivery systems

9 Liposomes

10 Advanced concepts in the design,

development and production of sustained

release products



release products



release products

13 Recent innovations in conventional dosage

form like tablets, capsules, sterile dosage

forms, pellets, Mucoadhesive system,

GRDDS etc.

14 Introduction of formulation of protein and

peptides

15 Introduction of formulation of protein and

peptides


Week Contents

1

2

3

4



Mid-term exam 1 80

Quiz - -

Project - -

Reports - -

Seminar - -

Assignments 2 10

Presentation - -

Laboratory - -

Field work - -

Total 1 100



(%)

- 40



- 60

Total 100


outcomes


1







3



other parties.











9




10







assurance.

13








16






18






racemization)

19








nanoformulations.

22




23







Class Hours 15 2 30



preparation) 1 5 5

Quiz 0 0 0



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 2 2 4

Presentation 0 0 0


year) 1 10 10

Project 0 0 0


Laboratory 0 0 0

Field Work 0 0 0

Total Workload 61



Nano Drug Delivery Systems and their Applications (EF4302)

ECTS: 2 2 h/w theory Period to be announced


Course objective:

The main objective of this course is to introduce the place of Nano Technology in

pharmaceutical applications, the advantages of Nano formulations to classic drugs and

to explain the materials and methods used in preparation of Nano Drug Delivery

Systems

Course contents:

A short review of the use of nano materials in prevention, diagnosis and treatment of

different diseases. Introducing different nano drug delivery systems, including gold nano

particles, carbon nanotubes, polymeric and lipid based materials and the advantages

and disadvantages of use of these materials for specified aims, like treatment of cancer,

rheumatoid arthritis, diabetes and Alzheimer’s disease. Uploading methods used to

upload drugs to different nano drug delivery systems. Explaining materials, methods and

instruments are used in characterization of nano drug delivery systems. Release studies

of nano drugdelivery systems and the pharmacokinetic of nano formulations.

Learning outcomes:

The graduates will gain a new point of view as an alternative for the traditional

pharmaceutical methods. They will learn how to use the possibilities of nano materials

for solving the problms associated with the traditional nano-formulations. They also will

become familiar with different materials such as polymers, cyclodextrines and chitosan

which are popular in production of nano-formulations

Form of tuition:


Course material:


Literature:

Entry requirements:

EF 3258



Week Contents

1 Introduction to nano scaled materials, pharmaceutical nano-formulations, their

applications and benefits

2 Polymeric drug delivery systems used in

production of nano-formulations.

3 Nano-capsules, nano-spheres and nano-gels

4 Nano-dendrimers

5 lipspmes

6 Niosomes

7 Solid lipid nano particles

8 Nano-emulsions

9 Micelles

10 Nano-crystals

11 Nano-tubes and nano-cages

12 Polymer-protein conjugates

13 Targeted drug delivery to cancer side using nano-formulations

14 Passing through Blood Brain Barrier using nano formulations

15 Are nano formulations safe?


Week Contents

1



Mid-term exam 1 50

Quiz 2 40

Project - -

Reports - -

Seminar - -

Assignments 2 10

Presentation - -

Laboratory - -

Field work - -

Total 5 100



(%)

- 40



- 60

Total 100




X


X


X


X


X


X


X


X


X


X


X



X


X


X


X


X

18


X


X


X


X


X


X




Class Hours 15 2 30



preparation) 1 5 5

Quiz 2 1 2



Reports 0 0 0



Seminar 0 0 0

Other 0 0 0


Assignments 2 2 4

Presentation 0 0 0


year) 1 5 5

Project 0 0 0


Laboratory 0 0 0

Field Work 0 0 0

Total Workload 53

Total Workload / 25 2,12


The Role of Enzymes in Diseases and Enzymes as targets for drug development (EF4303)



Course objective: Providing a basic understanding of enzymes in diseases. We will discuss examples of several important enzymes as drug targets for various diseases. Course contents: General introduction to enzymes; structure of enzymes; enzymes in physiology and

pathophysiology; enzyme reaction mechanisms; enzyme inhibition assays; important enzymes for pharmaceutical companies: CA, COX, AChE, BChE, ACE, proteases, reverse transcriptases. Learning outcomes: The students:

will be able to discuss enzymes and their characteristics will be able to discuss enzyme inhibition assays

will be able to discuss the physiological role of several important enzymes: CA, COX,

AChE, BChE, ACE, proteases, reverse transcriptases Form of tuition: Lectures, tutorials and self-study

Course material: Powerpoint presentations, internet Literature: -- Entry requirements:

None



1 introduction to enzymes

2 enzyme characteristics

3 enzyme structures

4 enzyme inhibition assays


6 carbonic anhydrases

7 carbonic anhydrases

8 acetyl/butyryl cholinesterases

9 acetyl/butyryl cholinesterases

10 cyclooxygenases

11 cyclooxygenases

12 proteases

13 proteases

14 reverse transcriptases

15 reverse transcriptases



Quiz

Project

Reports

Seminar

Assignments

Presentation

Laboratory

Field work

Total


40


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x




Other Applications


Quiz 1 2 1

Term Paper/ Project

Portfolio Study

Reports

Learning Diary

Thesis/ Project

Seminar

Other

Working Hours out of Class 15 1.8 27

Assignments

Presentation


Project

Clinical Practice

Laboratory

Field Work

Total Workload 60



Expertness lectures (during fifth year)

Development of New Analytical Methods and Validation (EF5321)

ECTS: 5 3 h/w theory; 2 h/w practice Period to be announced

Coordinator: Evrim Tekkeli, PhD

Course objective:

Providing students to be able to analyse different kinds of matrices, develop new

analytical methods and validate.

Course contents:

Quality control of drugs, qualitative and quantitative impurity analysis, determination of

excipients, bioequivalance and bioavailability, basic principles in developing new

methods, validation parameters (selectivity, linearity, accuracy, precision, robustness,

limit of dedection, limit of quantitation), the role of statistics in method validation and

applications, converting the data of analysis to reports.

Learning outcomes:

The students:

• will be able to develop a new analytical methods using chromatographic

techniques

• will be able to validate an analytical method

Form of tuition:


Course material:


Literature:

Instrumental analysis- Skoog; Goodman and Gilman’s The Pharmacological Basis of

Therapeutics; Guidance for Industry, Bioanalytical Method Validation, US Department of

Health and Human Services, Food and Drug Administration; Text on Validation of

Analytical Procedures Q2A, International Conference on Harmonisation of Technical

Requirements for Registration of Pharmaceuticals for Human Use.

Entry requirements:

None



Week Contents

1 Principles of method development and validation, studies on related ICH Guidelines

2 Principles of method development and validation, studies on related ICH Guidelines

3 Studying on how to choose applicable method

4 Chromatographic separation techniques

5 Suitable dedections for chromatographic process

6 Bioequivalance studies

7 Bioavailability studies

8 Quality control principles of pharmaceutical preparations

9 Interferences in analysis

10 Validation procedures

11 Validation parameters

12 Statistical test related to drug development

13 Data converting to an analyse report

14 Problem based studies about developing a new method for drug analysis

15

Problem based studies about developing a new method for drug analysis


Week Contents

1 ____

2 ____







9 HPLC study for drug analysis from pharmaceutical preparations



12 UPLC study for drug analysis from pharmaceutical preparations

13 UPLC study for drug analysis from biological fluids

14 Literature survey for new methods

15 Presentations about developing new methods for drug analysis



Mid-term exam 1 100

Quiz 2 10

Project 1 20

Reports --- ---

Seminar --- ---

Assignments ---

Presentation 1 5

Laboratory 14 ---

Field work --- ---

Total --- ---


40


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x




Other Applications


Quiz 2 4 4

Term Paper/ Project

Portfolio Study

Reports 2 3 6

Learning Diary

Thesis/ Project

Seminar

Other


Assignments

Presentation 1 5 5


1 6 6

Project 1 5 5

Clinical Practice

Laboratory 13 2 26

Field Work

Total Workload 125



Drug Analysis in Biological Fluids and Pharmaceutical Preparations (EF5322)

ECTS: 3 2 h/w theory; 1 h/w practice Period to be announced

Coordinator: Evrim Tekkeli, PhD

Course objective:

Learning the properties of different biological matrices, sample preparation techniques,

the characteristic properties of pharmaceutical preparations.

Course contents:

Basic principles of drug analysis in biological fluids, types of biological matrices,

pharmaceutical preparations and characteristics, sample preparation techniques and

their applications, derivatization and derivatizing agents, analysis with UV and

fluorimetric detections, investigating pharmacokinetics of drugs.

Learning outcomes:

The students:

• will be able to decide how type of an analytical method is suitable for a specific

matrix.

• will be get detailed information about biological fluids

• will be able to conduct a derivatization procedure

• will be able to describe pharmacokinetics and its importance for medicine

Form of tuition:


Course material:


Literature:

Instrumental analysis- Skoog; Goodman and Gilman’s The Pharmacological Basis of

Therapeutics; Guidance for Industry, Bioanalytical Method Validation, US Department of

Health and Human Services, Food and Drug Administration

Entry requirements:

None



Week Contents

1 Biological matrices, investigating the properties of plasma, serum, urine, cerebrospinal fluid, etc…

2 Biological matrices, investigating the properties of plasma, serum, urine, cerebrospinal fluid, etc…

3 Pharmaceutical formulations and their characteristics



6 Sample preparation techniques

7 Solid phase extraction and liquid-liquid extraction from biological fluids, protein precipitation

8 Derivatization

9 Derivatization

10 Analysis in biological fluids with examples



13 Pharmacokinetics of drugs

14 Pharmacokinetics of drugs

15

Problem based studies about developing a new method for drug analysis in various biological fluids


Week Contents

1 ____

2 ____




6 Spectrophotometric derivatization



9 Spectrofluorimetric derivatization






15 Presentations about developing new methods for drug analysis in biological studies



Mid-term exam 1 100

Quiz 2 10

Project 1 20

Reports --- ---

Seminar --- ---

Assignments ---

Presentation 1 5

Laboratory 13 ---

Field work --- ---

Total --- ---


40


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x




Other Applications


Quiz 2 4 8

Term Paper/ Project

Portfolio Study

Reports

Learning Diary


Seminar

Other

Working Hours out of Class

Assignments

Presentation 1 3 3


1 8 8

Project

Clinical Practice

Laboratory 13 1 13

Field Work

Total Workload 75



Computer-aided drug discovery I (EF5324)



Course objective: We will discuss ways in which ligands can bind selectively and with affinity to their target proteins. In addition, in silico screening procedures will be discussed. Course contents: Ligand binding interactions of several important drugs; development and validation of successful in silico screening procedures and their applications.

Learning outcomes: The students:

will be able to discuss how 3D structures of proteins can be obtained, what information can be extracted from them, and how they can be used in the design of new ligands

will be able to discuss structure-based and ligand-based design procedures will be able to discuss molecular dynamics simulations and what information can be

obtained from them

Form of tuition: Lectures, tutorials and self-study Course material:

Powerpoint presentations, internet Literature: -- Entry requirements: None



1 3D structures of proteins and ligands by NMR and X-ray

2 Protein-ligand interactions


4 Force fields and calculation of interaction energies

5 Sequence alignments and homology modelling

6 Pharmacophore models and ligand conformational alignments

7 Docking studies

8 Virtual screenings

9 Fragment-based screenings (NMR and in silico)

10 Scaffold hopping

11 De novo ligand generation

12 QSAR

13 3D-QSAR

14 Molecular dynamics




Quiz

Project

Reports

Seminar

Assignments

Presentation

Laboratory

Field work

Total


40


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x



Activity Number Time (hour) Total workload Class Hours

Other Applications

Final Examinations (including preparatory year)

Quiz

Term Paper/ Project

Portfolio Study

Reports

Learning Diary

Thesis/ Project

Seminar

Other


Assignments

Presentation


Project

Clinical Practice

Laboratory

Field Work

Total Workload

Total Workload / 25

ECTS Credit of Course

Computer-aided drug discovery II (EF5325)

ECTS: 5 3 h/w theory; 2 h/w practice Period: to be announced


Course objective: We will discuss ways in which ligands can bind selectively and with affinity to their target proteins. In addition, in silico screening procedures will be discussed. Course contents: Ligand binding interactions of several important drugs; development and validation of successful in silico screening procedures and their applications. This course will include a project and a

presentation. Learning outcomes: xxxxxxxx Form of tuition: Lectures, tutorials and self-study. Students will do a project and present their results.

Course material: Powerpoint presentations, internet Literature: --

Entry requirements: None



1 3D structures of proteins and ligands by NMR and X-ray



4 Force fields and calculation of interaction energies

5 Sequence alignments and homology modelling

6 Pharmacophore models and ligand conformational alignments

7 Docking studies

8 Virtual screenings

9 Fragment-based screenings (NMR and in silico)

10 Scaffold hopping

11 De novo ligand generation

12 QSAR

13 3D-QSAR





Quiz

Project

Reports

Seminar

Assignments

Presentation

Laboratory

Field work

Total


40


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x



Activity Number Time (hour) Total workload Class Hours

Other Applications

Final Examinations (including preparatory year)

Quiz

Term Paper/ Project

Portfolio Study

Reports

Learning Diary

Thesis/ Project

Seminar

Other


Assignments

Presentation


Project

Clinical Practice

Laboratory

Field Work

Total Workload

Total Workload / 25

ECTS Credit of Course

Molecular Pharmacology and Drug Discovery (EF5327)

ECTS: 5 3 h/w theory; 2 h/w practice Period: to be announced


Course objective: Providing working knowledge of molecular pharmacology and related techniques that are frequently used in drug discovery and development procedures. Course contents: This course will discuss commonly used (molecular) pharmacology based research techniques in drug design and development such as: mutagenesis studies, chimeric proteins, ligand-protein

interactions, binding assays, functional assays, enzyme inhibition assays, cell culture, protein-ligand cocrystallization studies, high-throughput screenings. Learning outcomes: The students:

will be able to discuss the role of frequently used (molecular) pharmacology techniques in drug discovery and development

will be able to learn and discuss new research techniques from the literature

Form of tuition: Lectures, tutorials, literature research and self-study Course material:

Powerpoint presentations, internet Literature: -- Entry requirements: None



1 introduction to molecular pharmacology

2 mutagenesis studies

3 chimeric proteins

4 ligand-protein interactions

5 binding assays

6 binding assays

7 functional assays

8 functional assays

9 functional assays



12 cell culture

13 cell culture

14 protein-ligand cocrystallization

15 protein-ligand cocrystallization



Quiz

Project

Reports

Seminar

Assignments

Presentation 1 40

Laboratory

Field work

Total


40


60




x


x


x


x


x


x


x


x


x


x


x



x


x


x


x


x

18


x


x


x


x


x


x




Other Applications


Quiz

Term Paper/ Project

Portfolio Study

Reports

Learning Diary

Thesis/ Project

Seminar

Other


Assignments

Presentation


1 10 10

Project 15 2 30

Clinical Practice

Laboratory

Field Work

Total Workload 132



course contents per week course contents lectures week ... · spectroscopy, fluorimetry 6...

Documents