CRIS Director’s Report

2016 CRIS Annual Meeting

October 6, 2016

Michael P. Holsapple, PhD, ATSDirector & Endowed Chair, CRIS

Professor, Food Science & Human Nutrition

A program that will broadly build capability in

chemical ingredient safety with specific and

targeted focus in three areas:

Scientific research

Risk communication

Education and training

What is CRIS?

Scientific

Research

(MSU)

Education

& Training

(MSU)

Risk

Communication

(ASU)

Components:

What is CRIS?

Let’s shift to Progress

Expand the opportunity to conduct basic and

applied research on the safety and toxicology

of ingredients in food, packaging, cosmetics,

and household care products

Areas of Engagement #1

What is CRIS?

Contribute to the development and validation

of testing methods and strategies for

evaluating the safety of ingredients in food,

packaging, cosmetics and household care

products

Areas of Engagement #2

What is CRIS?

Establish a graduate training program that

prepares scientists for a career in assessing

the safety and toxicology of ingredients in

food, packaging, cosmetics, and household

care products that includes training in risk

assessment and regulatory policies

Areas of Engagement #3

What is CRIS?

Scientific

Research

(MSU)

Education

& Training

(MSU)

Risk

Communication

(ASU)

Created new track within MSU

Environmental & Integrative

Toxicology (EITS) Graduate

Program:

Food Toxicology &

Ingredient Safety (FTIS)

(Launching in Fall, 2016)

What is CRIS?

Inform the public, health professionals,

regulators, and the scientific community on

research matters reflecting the state-of-the-

science pertaining to the safety and

toxicology of ingredients in food, packaging,

cosmetics, and household care products

Areas of Engagement #4

What is CRIS?

Actively participate in dialog on important

ingredient safety issues to support evidence-

based decision making

Areas of Engagement #5

What is CRIS?

Highlight of Select CRIS Activities

ACT AM, Summerlin, NV – November 8-10, 2015

CRIS AM, MSU – November 11-12, 2015

SOT CCT – FutureTox III, Arlington, VA – Nov 19-20, 2015

EITS Research Evening, MSU – November 23, 2015

Mtg w/ VP, RGS, MSU – December 1, 2015

Mtg w/ Chair, Pharmacology, MSU – December 7, 2015

Visit to Kellogg, Battle Creek, MI – December 10, 2015

CRIS Strategic Planning, MSU – January 20-21, 2016

CFS AM, Atlanta, GA – March 1-2, 2016

Mtg w/ Dept/School Chairs, MSU – March 4, 2016

Highlight of Select CRIS Activities

SOT AM, New Orleans, LA – 03/13-17/16

Mtg w/ Nestle Purina, MSU – 03/22/16

Mtg w/ Chair, Sch of Packaging, MSU – 03/29/16

Mtg w/ Chair, Chemistry, MSU – 04/01/16

Mtg w/ Chair, Biosystems & Ag Eng, MSU – 04/04/16

Mtg w/ Chair, Communication, MSU – 04/08/16

Visit to Mead Johnson Nutr, Evansville, IN – 04/13-14/16

Invited guest to SoP Adv Board Mtg, MSU – 04/15/16

GMA Science Forum, Washington, DC – 04/18-21/16

Mtg w/ ILSI NA ED/staff, Washington, DC – 04/18/16

Highlight of Select CRIS Activities

Mtg w/Chair, Material Science & Eng, MSU – 04/25/16

Ann’l Fac. Rev. w/ Chairs, FSHN & PHM, MSU – 06/01/16

Mtg, CRIS EAC, EIC & IAC, Detroit, MI – 06/13-14/16

Mtg w/ Chair, Micro & Molec Genetics, MSU – 07/01/16

IFT AM, Chicago, IL – 07/17-19/16

IAFP AM, St. Louis, MO – 07/31 to 08/03/16

Visit to Monsanto, St. Louis, MO – 08/03/16

Mtg w/ interim Chair, Biomed Eng, MSU – 08/29/16

Mtg w/ Provost, MSU – 09/01/16

CRIS AM, MSU – 10/04-06/16

CRIS Strategic Map

Mission (Why CRIS exists):

Conduct research and provide insight on the

safety of ingredients in food and consumer

products to support evidence-informed

decisions by consumers, industry and policy

makers

CRIS Strategic Map

Vision (long-term outcome for CRIS):

Credible, relevant information on

ingredient safety is accessible to a wide

range of decision makers

Implement Projects toEstablish the Credibility andImpact of CRIS

Develop andImplement aFocusedResearchAgenda

LaunchPrioritizedEducation andTraining

Secure theBase of NeededResources

BuildAdaptiveCommunicationCapability

Develop CoreOrganizationCapabilities

A B D EC

Central Challenge

Strategic

Priorities

CRIS Strategic Map

http://iit.msu.edu/cris/index.html

Identify and

Prioritize the

Research Agenda

Implement

High-Priority

Short-term

Research Projects

Support

Development of the

Food Toxicology &

Ingredient Safety

PhD Program

Develop and

Implement

Long-term

Research Portfolio

Steward,

Maintain and

Grow Partner

Subscriptions

Steward and

Maintain

MSU Support

Use CRIS to

Generate

Preliminary Data to

Compete for

Federal Funds

Build Relationships

with Key

Stakeholders

Establish a Media

Network and

Engagement

Strategy

Cultivate and

Implement

Individually-Funded

Projects

Develop

Ingredient Safety

Workshop(s)

Design and

Implement Safety

Communication to

a Lay Audience

Implement By-laws

and Integrate the

CRIS Governance

Processes

Implement Plan

to Recruit/Secure

Faculty

Engagement

Recruit CRIS

Tenure Track

Faculty

Integrate

Science into the

CRIS Annual

Meeting

Establish Website/

Portal to Manage

Recognition of

CRIS Contributions

1

2

3

4

5

6

Develop andImplement aFocusedResearchAgenda

LaunchPrioritizedEducation andTraining

Secure theBase of NeededResources

BuildAdaptiveCommunicationCapability

Develop CoreOrganizationCapabilities

A B D EC

Develop and

Implement the

Emerging Issues

Process

Establish Processes

To Monitor, Assess

and Respond to

Emerging Issues

Facilitate

Education in

Ingredient Safety

at MSU

Assess Workforce

Needs for

Ingredient Safety

Toxicologists

Cultivate/Maintain

Critical Partners:

GMA, Industry,

Academic, NGOs

and Government

Provide Access

to a Network

of Technical

Expertise

Develop and

Implement a

Strategy to

Promote CRIS

Strategic

Priorities

Strategic

Objectives

CRIS Strategic Map

CRIS Strategic Map

Identify and

Prioritize the

Research Agenda

Implement

High-Priority

Short-term

Research Projects

Build Relationships

with Key

Stakeholders

Establish a Media

Network and

Engagement

Strategy

Implement By-laws

and Integrate the

CRIS Governance

Processes

Implement Plan

to Recruit/Secure

Faculty

Engagement

Recruit CRIS

Tenure Track

Faculty1

2

3

Develop andImplement aFocusedResearchAgenda

LaunchPrioritizedEducation andTraining

Secure theBase of NeededResources

BuildAdaptiveCommunicationCapability

Develop CoreOrganizationCapabilities

A B D EC

Develop and

Implement the

Emerging Issues

Process

Establish Processes

To Monitor, Assess

and Respond to

Emerging Issues

Priority

Tracks of

Work for

YR 1

Scientific Research Plan

• Develop and implement the Emerging Issues process

• Identify and prioritize the research strategy

• Implement high-priority, short-term research projects

2016 Priority Tracks of Work

Scientific Research

• Working with EIC to improve Emerging Issues Process

• Continue to network with MSU academic unit leaders

• Distributed list of 10 topics for ‘white papers’ across MSU campus (authors lined up for 6)

• Developed list of 15 ‘Tier 1’ research projects

• Posted an RFP for MSU on 08/01/16

Recent Milestones

• Alternative approaches & Tox 21: Case study –endocrine disruptive chemicals

• Emulsifiers: Potential impacts on the gut microbiome **

• Epidemiological evidence: Bringing together

epidemiology, nutrition science & toxicology **

• Metals: Putting their impact on food safety into

context **

• Trichothecene Mycotoxins: Mechanism-based

safety assessment **

Top Choices for Papers

• N-hexane: Role of metabolism and relevance to humans

• Phycotoxins: Impact of these water-borne toxins on food safety

• Preservatives / antimicrobials: Review the risks

and benefits **

• Residual aquaculture drugs in farmed seafood:

Rising demand; but is it safe?

• Unavoidable contaminants or constituents: The

need for a new science-based approach **

Top Choices for Papers

TARGET AREAS OF STUDY• Applications of alternative testing for ingredient safety

• Effects of ingredients on microbiota

• Impact of Maillard Reaction products on food safety

• Application of exposure science / modeling for

ingredient safety

• Mycotoxins and food safety risks

• Investigator-initiated proposals relevant to CRIS

Mission

Will fund at least two awards of $75K starting on 01/01/17

CRIS RFP – Fall, 2016

Communication Plan

• Establish processes to monitor, assess and respond to emerging issues

• Build relationships with key stakeholders

• Establish a media network and engagement strategy

2016 Priority Tracks of Work

Communication / Outreach

• Established CRIS Website (MSU)

• Recruited post-doctoral fellow (ASU)

• Created CRIS Connects (monthly

newsletter; MSU)

• Launched CRIS Bits (blog; ASU)

• Networking with NGO community (ASU)

Recent Milestones

CRIS Bits – Insights into the Science of Food

Safety (crisbits.org/)

About Us – CRIS Bits is an editorially independent

blog from Michigan State University Center for

Research on Ingredient Safety. It covers expert

insights into the science of ingredient safety

Suggest a topic

• Have something you’d like us to write about?

• Please send your ideas to our Senior Editor Dr. Keri

Szejda, and we’ll see what we can do.

ASU blog

ASU blog

Update: FDA will “Exercise Discretion” with Healthy Food Labeling

by Keri Szejda September 27, 2016

Introduce Eggs and Peanuts Early in Infants’ Diets to Reduce the

Risk of Allergies by Guest Author September 22, 2016

Dose-Response. A Complicated Relationship? by Keri Szejda

September 21, 2016

Hazard and Risk – What’s the Difference? by Keri Szejda September

16, 2016

For Antibacterial Soaps, Context Matters by Guest Author September

14, 2016

Why Parents and Pupils Are Finding Healthy Packed Lunches Hard

to Stomach by Guest Author September 14, 2016

ASU blog

Will This Formula Make My Baby Cry Less? by Keri Szejda

September 9, 2016

FDA Makes Final Ruling on Antibacterial Soaps by Keri Szejda

September 3, 2016

Better Safe Than Sorry: Insect Repellents in the Age of Zika by Keri

Szejda August 31, 2016

One More Day for Public Comment on the FDA’s “Voluntary

Sodium Reduction Goals” by Keri Szejda August 30, 2016

Spray-on Food Packaging…That You Can Eat by Keri Szejda August

25, 2016

Why public health worries don’t have to ruin your cookie dough by

Guest Author July 18, 2016

ASU blog

News Brief: FDA Plans to Reevaluate Food Labeling Regulations

by Keri Szejda July 16, 2016

Should French consumers be worried about nanoparticles in their

food? by Andrew Maynard July 11, 2016

Which foods are “healthy”? by Keri Szejda July 7, 2016

How do food manufacturers pick those dates on their product

packaging – and what do they mean? by Guest Author June 27, 2016

GM food labeling: risk communication researcher finds that

consumers desire transparency and input in decision making by

Guest Author June 27, 2016

Raise a cup — of coffee; WHO no longer says it can cause cancer

by Keri Szejda June 16, 2016

ASU blog

Worried about arsenic in your baby’s rice cereal? There are other

foods that can provide essential iron by Keri Szejda May 25, 2016

Nanoparticles in baby formula: should parents be worried? by

Andrew Maynard May 17, 2016

News Brief: CRF Frozen Foods Expands Recall of Frozen Fruits

and Vegetables by Keri Szejda May 6, 2016

New Analysis of Old Data: A Paradox to the Diet-Heart Hypothesis?

by Keri Szejda April 25, 2016

Consumer Reactions to Europe’s Horsemeat Scandal by Keri Szejda

April 13, 2016

Bisphenol A (BPA) Questions and Answers by Andrew Maynard March 31, 2016

Resources & Core Capabilities

• Recruit CRIS tenure track faculty

• Implement plan to recruit / secure faculty engagement

• Implement by-laws and integrate the CRIS governance process

2016 Priority Tracks of Work

CRIS tenure-stream faculty

• Computational biologist/toxicologist

• Identified a candidate who is an ideal fit for this position

• Exposure science/modeling

• Search committee identified three solid candidates

• ‘skype’ interviews are being scheduled for week of October 17th

Recent Milestones

Plan for faculty engagement

• Continuing to network on campus

• Posted CRIS RFP

• Recruited speakers from across campus

for the 2016 AM

Recent Milestones

Implement by-laws & governance process

• draft bylaws developed in late April; have been reviewed by MSU General Counsel, MSU Business Connect, IAC, EAC, EIC

• MSU GC & BC now working with GMA GC

• Successfully integrated Chair / Vice Chair leadership into EAC & EIC

• Developed charters for IAC, EAC & EIC

Recent Milestones

Save the Date!!!

2017 Annual Meeting of CRIS

• Dates: October 3 – 5, 2017

• Location: Phoenix, AZ

• Hosts: ASU Team (Andrew Maynard, Di Bowman, and Keri Szjeda)