Ii i= "z JL

22nd International Symposium on HalogenatedEnvironmental Organic Pollutants and Persistent

Organic Pollutants (POPs)

Barcelona, Spain - August 11-16, 2002

Organized by:Spanish Council for Scientific Research

Laboratory of Dioxins

CSIC

With the collaboration of:

vi mmUNIVERSITATDEBARCELONA !• I I I / Generalitat de Catalunya

JJ i Departament de Medi Ambient

Plenary lecture

THE COMBINED EFFECT OF ENVIRONMENTAL HORMONES AND THE RISK OFHORMONE DEPENDENT DISEASESNicolas Olea

Environmental levels: biotic compartments (cont.)

ACCUMULATION PATTERN OF ORGANOCHLORINES IN JUVENILES OFARCTOCEPHALUS AUSTRAUS FOUND STRANDED ALONG THE COAST OFSOUTHERN BRAZIL 5Gilberto Fillmann , Luciano Hermanns, Tim W. Fileman and James W. Readman

LEVELS OF ORGANOHALOGENATED POLLUTANTS (PCBS, OCPS AND PBDES) INBIOTA FROM THE DANUBE DELTA, ROMANIA 9A. Covaci. A. Gheorghe, O. Hulea, P. Schepens

PERSISTENT ORGANIC POLLUTANTS IN MURRE EGGS FROM THE BERING SEAAND GULF OF ALASKA 13John R, Kucklick. Stacy S. Vander Pol, Paul R. Becker, Rebecca S. Pugh, Kristin

Simac, Geoff W. York and David G. Roseneau

CONCENTRATIONS AND CONGENER PROFILES OF PCBS AND PCDDS/PCDFSIN FAT AND LIVER TISSUES OF WILD DUCKS COLLECTED IN NEW YORKSTATE 17Patrick W. O'Keefe, , William Clayton, Steven Connor, Chia-Swee Hong and Robin

Storm

ACCUMULATION LEVELS OF 2,3,7,8-SUBSTITUTED DIOXINS IN THEAMPHIBIANS FROM THE BASINS OF MAJOR RIVERS IN S. KOREA 21Gi Ho Jeong, Dong-Ho Moon. Chang-Han Joo and Jae-Cheon You

ACCUMULATION OF POLYCHLORINATED BIPHENYLS IN AMPHIBIANS FROMTHE BASINS OF MAJOR RIVERS IN S.KOREA 25Gi Ho Jeong, Young Bok Kim, Do Yeon Kim, Mee Ok Kim, Ji Young Lee, Chang Han

Joo. Dong Ho Moon

PRELIMINARY EVALUATION OF ORGANOCHLORINE CONTAMINANTS (PCDDS,PCDFS, PCBS AND DDTS) IN BIRDS FROM BAJA CALIFORNIA, MEXICO 29Ruben Merino, Ricardo Rodn'guez-Estrella, Laura Rivera, Esteban Abad, Josep Rivera

and Begona Jimenez

LEVELS OF PCDD/PCDF AND SOME SELECTED MONO-, DI- AND NON-ORTHOSUBSTITUTED PCB IN MUSSELS AND FISH FROM A MEDITERRANEANCOASTAL AREA INFLUENCED BY CHEMICAL INDUSTRY 33W. Sunderhauf. J.L. Domingo, J.M. Llobet, L.Miiller

PCDD/F surrogates and gas monitoring systems forcombustion process monitoring

DIOXIN SURROGATES - A COMPARISON OF APPROACHES 37Oberg. T.: Neuer-Etscheidt, K.; Nordsieck, H.OH; Zimmermann R.

MEASURING DIOXINS' PRECURSORS - A WAY TO ENSURE A CLEANERENVIRONMENT 45Elena Daniela Lavric. Alexander A. Konnov and Jacques De Ruyck

SHORT TERM DE NOVO FORMATION OF PCDD/PCDF AND CORRELATION TOPOLYCHLORINATED BENZENES AS SURROGATES 49Roland Weber and Takeshi Sakurai

APPLICATION OF CONCENTRATION OF ORGANOHALOGEN COMPOUNDSIN FLUE GAS FOR THE MANAGEMENT OF DIOXINS 53Katsuya Kawamoto, Takashi Imaizumi, Hideaki Fujiyoshi and Masara Tanaka

A SENSOR CONCEPT FOR ON-LINE DETECTION OF PCDD/F-MEMORYFORMATION IN WASTE INCINERATOR FLUE GAS 57T. Streibel. M. Blumenstock, F.Miihlberger, T.Hauler, R. Zimmermann

MONITORING TECHNIQUE OF PCDDS/DFS FROM MSW INCINERATORS USINGDIOXIN PRECURSOR ANALYZER 61Masara Tanaka, Hideaki Fujiyoshi, Satoshi Hatazawa, Takashi Yokoyama, Hideki

Nagano. Toshihiko Iwasaki

REAL-TIME MONITORING OF DIOXIN PRECURSORS BY APCI-ITMS: CONTROLOF CATALYST INJECTION 65Masuyoshi Yamada. Izumi Waki, Minoru Sakairi, Masami Sakamoto and Tomoyuki

Imai

ON-LINE DETECTION OF AROMATIC COMBUSTION BY-PRODUCTS FROM ALEAN METHANE FLAME USING JET-REMPI-TOFMS 69Harald Oser. Lukas Oudejans, Michael J. Coggiola, Gregory W. Faris, David R. Crosley

and Brian K. Gullett

PROTOTYPE OF A MONITORING SYSTEM FOR ENVIRONMENTAL ORGANICPOLLUTANTS AND POPS IN STACK GASES OF THERMAL PROCESSES 73Thomas Ludwig. Johannes Jager

RESULTS OF ONE YEAR CONTINUOUS MONITORING OF THE PCDD/PCDFEMISSIONS OF WASTE INCINERATORS IN THE WALLOON REGION OFBELGIUM WITH AMESA® 77Jiirgen Reinmann

CONTINUOUS MONITORING OF DIOXIN EMISSIONS FROM A WASTE WOODCOMBUSTION PLANT 81Johannes Mayer. Rainer Grtimping

VALIDATION OF A STACK SAMPLING METHOD ACCORDING TO EN 1948 FORPCDD/F AND OTHER SEMI-VOLATILE ORGANIC COMPOUNDS 85Johannes Mayer. Ewald Manske

ANALYSIS OF CHLOROPHENOLS IN FLUE GAS OF WASTE INCINERATORSBY HPLC/ECD INSTALLED IN SEQUENTIAL AUTOMATED MONITORINGINSTRUMENT AS WELL AS BY HPLC/MS AND GC/MS 89Ikuo Watanabe. Masako Kudo, Yasundo Kurata, Kazuhiko Yamasaki, Chiaki Terashima,

Takashi Ikeguchi

INVESTIGATION OF TARGET ISOMERS AS AN INDICATOR FOR TOXICEQUVALENTS QUANTITY OF DIOXINS AND RELATED COMPOUNDS INFLUE GAS 93Takahiko Matsueda. Kazuhiro Tobiishi, Takeshi Kuroivva, Makoto Moriguchi,

Yoshifumi Hanada, Yasuhisa Ishiguro, Totaro Imasaka

OBTAINING DIOXIN VALUES WITH LOW UNCERTAINTY USING AUTOMATICLONG -TERM- SAMPLING EQUIPMENT AND DATA EVALUATION 97Gerhard Kahr. Thomas Steiner

APPLICATION OF CONTINUOUS DIOXIN MONITORING TECHNIQUEACCORDING THE EUROPEAN STANDARD AT HIGH DUST LEVELSAT A BRICK PRODUCTION PLANT AND CALULATION OF THE ANNUALMASS FLOW 101Thomas Steiner. Gerhard Kahr

DEVELOPMENT OF SIMPLE AND ACURATE EVALUATION METHOD ON AIRPOLLUTION BY DIOXIN ANALOGUES USING JAPANESE BLACK PINENEEDLE AS AN INDICATOR 103Hideaki Miyata. Naoki Iwata, Teruyuki Nakao, Osamu Aozasa, Akio Simamura and

Souichi Ohta

Risk Assessment

TRENDS IN THE RISK ASSESSMENT STRATEGY OF PERSISTENT ORGANICPOLLUTANTS. THE EUROPEAN PERSPECTIVE 107Jose V. Tarazona

CHEMICAL AND TOXICOLOGICAL RISK ASSESSMENT OF NORTH SEA SURFACESEDIMENTS. BROMINATED FLAME RETARDANTS AND DIOXIN-TYPETOXICITY IllHans J.C. Klamer. Pim E.G. Leonards and Joop F. Bakker

DIOXIN-LIKE CHEMICALS — A MATTER OF CONCERN FOR THEMEDITERRANEAN FAUNA? 115Roberto Miniero. Elena De Felip and Alessandro di Domenico

PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING AS A TOOL FORPREDICTING DOSE RESPONSE RELATIONSHIP FOR TCDD DURINGDEVELOPMENT 119Claude Emond. Michael J. DeVito and Linda S. Birnbaum

A PROPOSED REFERENCE DOSE FOR DIOXIN OF 1-10 PG/KG-DAY: AWEIGHT-OF-EVIDENCE EVALUATION OF THE HUMAN STUDIES 123Jessica F. Greene and Dennis Paustenbach

PROPOSAL FOR A GUIDELINE FOR DIOXIN DEPOSITION IN EUROPE:UNCERTAINTY ANALYSIS 127Johan Nouwen. Jeroen Provoost, Christa Cornelis, Raf De Fre, Marjory Desmedt

COMPARISON OF ASSESSING LEVELS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN IN SELECTED POPULATIONS BY BIOMONITORING AND EXPOSUREINDICES 131Larry L. Needham, Donald G. Patterson, Jr. and Wayman E. Turner

SEXUAL DIFFERENCE IN EFFECTS OF DIOXINS ON IMMUNE RESPONSESYSTEM IN JAPANESE INFANTS 135Junya Nagavama, Hiroshi Tsuji, Takao Iida, Hironori Hirakawa, Takahiko Matsueda,

Jun'ichiro Fukushige and Tadayoshi Watanabe

iXPOSURE TO PERSISTENT TOXIC SUBSTANCES AND HEALTH EFFECTS INAT-RISK POPULATIONS IN THE U.S. GREAT LAKES-A SENTINELENVIRONMENT 139Heraline E. Hicks. Annette Ashizawa, William Cibulas and Christopher T. De Rosa

STUDIES ON AROMATIC COMPOUNDS. REMARKABLE DIFFERENCE IN THEMOLECULAR ELECTROSTATIC POTENTIAL AND DIPOLE MOMENT OFTOXIC AND NON-TOXIC POLYCHLORINATED BIPHENYLS 143Bernardo Herradon, Antonio Chana. Miguel A. Concejero, Mercedes de Frutos, Maria

J. Gonzalez

THE USE OF MULTIMEDIA MODELS FOR HEALTH RISK ASSESSMENT TOPCDD/FS 147Montse Meneses, Marta Schuhmacher and Jose L. Domingo

SUBSTANCE FLOW ANALYSIS: A POTENTIAL TOOL FOR HEALTH RISKMANAGEMENT OF PCDD/FS 151Gerard Fuster, Marta Schuhmacher and Jose L. Domingo

EFFECT OF LOW DOSE MONO-ORTHO 2,3',4,4',5 PENTACHLOROBIPHENYL(PCB 118) ON THYROID HORMONE STATUS AND EROD ACTIVITY IN RATOFFSPRING: CONSEQUENCES FOR RISK ASSESSMENT. 155Sergio Kuriyama, Antonio Fidalgo-Neto, Wolfgang Mathar, Karen Friedrich and

Ibrahim Chahoud

INTERACTION PROFILE FOR A MIXTURE OF PCBS, TCE AND RADIONUCLIDES .... 159Hana R. Pohl. Mark Osier, Peter McClure, Christopher T. De Rosa

DIOXIN MANAGEMENT STRATEGIES AND RISK VIEWS: THEORETICALFRAMEWORKS, DOCUMENT ANALYSES AND OPINION SURVEYAPPROACHES 163Timo Assmuth and Mikael Hilden

EFFECTS OF SUBCHRONIC EXPOSURE TO FRACTIONS OF BALTIC HERRINGOIL ON METAPHYSEAL BONE OF RAT FEMUR 167Natalia Stern. Monica Lind, Mattias Oberg, Soren Jensen and Helen Hakansson

USING TISSUE DOSE OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXlN (TCDD)AS A PREDICTIVE RESPONSE FOR REVERSIBLE BIOCHEMICAL CHANGES 171Janet J. Diliberto, Michael J. DeVito and Linda S. Birnbaum

DETERMINATION OF 40 PBDE IN RIVER SEDIMENTS FROM PORTUGAL 175Silvia Lacorte. Miriam Guillamon, Elena Martinez, Marco Mantilla, Paula Viana and

Damia Barcelo

CONGENER SPECIFIC EVALUATION OF HUMAN TOXICITY POTENTIALS FORPCDD/FS, CO-PCBS AND HCB WITH FISH INTAKE 179Yasuhiro Hirai. Hiroshi Takatsuki and Shin-ichi Sakai

EXPRESSION OF CYTOCHROMES P450 1A1, 1A2 AND 1B1 ARE CORRELATEDWITH DIOXIN LEVELS IN HUMAN LIVER 183Jean A. Grassman. Larry L. Needham, Scott A. Masten, Donald Patterson, George W.

Lucier and Nigel J. Walker

A. METABOLISM-BASED BIOMAGNIFICATION MODEL FOR THE PREDICTION OFCONCENTRATIONS AND EFFECTS OF DIOXINS IN HIGH TROPHIC LEVELS 187Milagros Vega, Maria Victoria Pablos, Jose Maria Navas. Jose Vicente Tarazona

CHLORINATION EFFECTS ON PCBZS, PCPHS, PCDD/DFS AND PAHS BYDIOXIN-FREE FLYASH AND UNBURNT HYDROCARBON: 1. EFFECT OFTEMPERATURE 191Takumi Takasuga. Norihito Umetsu, Tetsuya Makino and Katsuya Tsubota

Formation and sources: field cases

AMOUNTS AND SOURCES OF PCDD/FS IN THE GULF OF FINLAND 195Pirjo Isosaari. Harri Kankaanpaa, Jukka Mattila, Hannu Kiviranta, Matti Verta, Simo

Salo and Terttu Vartiainen,

POLYCYCLIC AROMATIC HYDROCARBONS, PENTACHLOROPHENOL, DIOXINSAND FURANS IN WASTE WOODEN SLEEPERS ON THE RECYCLING MARKET... 199Misuzu Asari. Hiroshi Takatsuki, Shin-ichi Sakai

DIOXIN ASSESSMENT IN COAL-FIRED POWER STATIONS FROM SPAIN 203G. Fernandez-Martinez, J.M. Lopez- Vilarino, P. Lopez-Mahia, S. Muniategui-Lorenzo,

D. Prada-Rodriguez, E. Abad and J. Rivera

PCDD/FS IN THE ATMOSPHERE AND COMBUSTED MATERIAL DURING AFOREST FIRE IN QUEENSLAND, AUSTRALIA 207Joelle A. Prange. Melinda Cook, Olaf Papke, Jochen F. Miiller and Roland Weber

PCDD/PCDF EMISSIONS FROM STATIONARY SOURCES - FIRST RESULTS FROMTHAILAND 211H. Fiedler, P. Chareonsong, J. Mayer and H.-U. Hartenstein

DIOXIN REMOVAL BY SLURRY WET SCRUBBING 215M. Bodini, A. Bassetti, S. Rossini, O. Bergamaschi, F. Dionigi, M. Donega, G. Ferrini,

W. Tirler, G. Voto

POLYCHLORINATED BIPHENYL (PCB) CONCENTRATIONS INATMOSPHERICALLY DERIVED ORGANIC FILMS FROM LOWERMANHATTAN AFTER SEPTEMBER 11, 2001 219Craig M. Butt, Jennifer Truong, Miriam L. Diamond and Gary A. Stern

DIOXIN CONCENTRATION IN LIQUID CHLORINE USED FOR WATERPURIFICATION 223Yasumoto Magara. Takako Aizawa, Masanori Ando, Yoshie Seki and Tohru Matsumura

LEVELS OF PCDD/PCDFS AND DIOXIN-LIKE PCBS IN DIFFERENT FEEDMATERIALS OF PLANT ORIGIN FROM GERMANY 227P. A. Behnisch. R. Ludwigs und K. Klostermann

REGULATION AND CONTROL OF THE EMISSIONS OF PCDD/F IN FRANCE 231Caroline Perrin. Laurent Vasse, Peter Luthardt and Jochen Schulte

PCDD/FS IN AMBIENT AIR AT THE WORLD TRADE CENTER 235Laura Webb. Marcus Kantz, Mark Winter, Dan Vallaro and Alan Vette

THREE YEARS OF DIOXIN MONITORING NEAR THE ATSUGI BASE IN JAPANFOR CONCENTRATIONS IN PRE- AND POST-BAG FILTER INSTALLATIONAND AFTER FACILITY CLOSURE 239Yuji Horie

AN ALTERNATIVE HYPOTHESIS TO NATURAL PCDD FORMATION 243Caroline Gaus. Joelle A. Prange, Olaf Papke, Jochen F. Miiller and Roland Weber

THE CONCENTRATIONS OF PCBS IN DUST-FALL COLLECTED IN IRON ANDSTEEL INDUSTRIAL COMPLEX, KOREA 247In-Ho Kim. Young-Min Kim, Min-Kyun Kim and Byoung-Eog Kim

VERTICAL DISTRIBUTION OF PCDD/FS IN FOREST SOIL FROM QUEENSLAND,AUSTRALIA 251Joelle A. Prange. Caroline Gaus, Olaf Papke, Roland Weber and Jochen F. Miiller

ASSESSMENT OF EMISSIONS OF ORGANIC MICROPOLLUTANTS AFTER ANACCIDENTAL FIRE IN A COAL BURNING ELECTRICAL POWER PLANT 255D. Voutsa, H. Terzi, C. Samara, Th. Kouimtzis, L. Muller

LEVELS OF PCDD/FS IN A FIRE ACCIDENT OF PRIVATE RESIDENCE INHSINCHU, TAIWAN 259Ukai Chou. P.S. Cheng, M.S. Hsu, Edward Ma, M.W. Lia, J.T. Wang and Y.C. Ling

NATURAL FORMATION OF DIOXINS: A REVIEW OF TRENDS AMONGFOUR SITES 263Damien Gadomski. Erin Golden and Robert L. Irvine, Jeffrey W. Talley, Lakhwinder

S. Hundal

Other halogenated POPs of concern

GLOBAL DISTRIBUTION AND BIOACCUMULATION OF PERFLUORINATEDHYDROCARBONS 267Kurunthachalam Kannan and John P. Giesy

NATURAL HALOGENATED ORGANOHALOGENS - A "NEW" SERIES OF POPS 271Walter Vetter

FLUORINATED SURFACTANTS ~ ENVIRONMENTAL & ANALYTICALCHEMISTRY 275Scott A. Mabury, Jon Martin, Cheryl Moody, David Ellis and Derek Muir

CARBON SKELETON ANALYSIS OF CHLOROPARAFFINS IN SEDIMENT,MUSSELS AND CRABS 279Sabine Kemmlein, Anne Hermeneit, Wolfgang Rotard

POLYCHLORINATED PYRENES (PCPYS) - A LESS STUDIED AND POSSIBLYTOXIC GROUP OF POPS 283Jerzy Falandysz, Tomasz Puzyn

ENANTIOSELECTIVE SEPARATION OF CHIRAL METHYLSULFONYL-PCBSTANDARDS BY PREPARATIVE HPLC USING METHYLATED CYCLODEXTRINPHASES 287Heinrich Huhnerfuss. Nils Peters, Jens Dobler, Christina Larsson, Ake Bergman,

Ekkehard Geidel

POLYCHLORINATED PYRENES (PCPYS) - SIMILARITIES TO ANOTHER POPS 291Tomasz Puzyn, Jerzy Falandysz, Masahide Kawano

EVALUATION OF MS IONISATION MODES (El, PCI AND NCI) FOR THEANALYSIS OF CHLORINATED PARAFFINS 295P. Castells. FJ. Santos and M.T. Galceran

POLYBROMINATED DIPHENYL ETHERS (PBDES), POLYBROMINATEDDIOXINS/FURNAS (PBDD/FS) AND MONOBROMO-POLYCHLORINATEDDIOXINS/FURANS (MOBPXDD/FS) IN ATMOSPHERE AND BULKDEPOSITION IN KYOTO, JAPAN 299Kenichi Hayakawa. Hiroshi Takatsuki, Isao Watanabe, Shin-ichi Sakai

POLYCHLORINATED ALKANES IN AMBIENT AIR FROM BEAR ISLAND 303Anders R. Borgen. Martin Schlabach, Roland Kallenborn, Guttorm Christensen and

Trond Skotvold

ENVIRONMENTAL FATE AND BEHAVIOR OF HCH ISOMERS IN A SOIL-PLANTSYSTEM IN A CONTAMINATED SITE 307M. Carmen Monterroso. Marta Camps Arbestain, Roberto Calvelo Pereira, Beatriz

Gomez Garrido, Soledad Muniategui Lorenzo, Purification Lopez Mahia, Dan'oPrada and Felipe Macfas

THE FIRST ENVIRONMETAL SURVEY OF PERFLUOROOCTANE SULFONATE(PFOS) AND RELATED COMPOUNDS IN JAPAN 311Sachi Taniyasu, Kurunthachalam Kannan, Yuich Horii and Nobuyoshi Yamashita

PRODUCTION OF POLYCHLOROTERPENES IN THE USSR 315Vladimir A. Nikiforov

LEVELS OF PERFLUOROOCTANE SULFONATE (PFOS) AND OTHER RELATEDCOMPOUNDS IN THE BLOOD OF JAPANESE PEOPLE 319Shigeki Masunaga. Kurunthachalam Kannan, Rikuo Doi, Junko Nakanishi, and John

P. Giesy

ANAEROBIC DEGRADATION OF TOXAPHENE BY THE ISOLATEDMICROORGANISM DEHALOSPIRILLUM MULTIVORANS 323Steffen Ruppe, Anke Neumann, Walter Vetter

Epidemiology

CONSIDERATION OF A LINK BETWEEN DIOXINS AND DIABETES 327Rene B.J. Remillard and Nigel J. Bunce

HYPERTENSION AND SERUM 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN(TCDD) AND HYPERTENSION IN THE AIR FORCE VETERANS OF THEVIETNAM WAR 331James H. Dwyer, William G. Jackson Jr and Joel E. Michalek

HEALTH EFFECTS OF LOW DOSE EXPOSURE OF POLYCHLORINATEDDIBENZO-P-DIOXINS, DIBENZOFURANS AND COPLANAR PCB AMONGJAPANESE RESEDENTS 335Shaw Watanabe. Takao Iida, Megu Ohtaki and Jamshid Hosseinpour

SERUM DIOXIN CONCENTRATIONS AND ENDOMETRIOSIS: A COHORTSTUDY IN SEVESO, ITALY 339BrendaEskenazi. Paolo Mocarelli, Marcella Warner, Steven Samuels, Paolo Vercellini,

David Olive, Larry Needham, Donald Patterson, Pier Mario Gerthoux, PaoloBrambilla

CANCER IN HUMANS RELATED TO EXPOSURE TO CHEMICALS CONTAMINATEDWITH 2,3,7,8-TCDD: THE NIOSH STUDIES 343Marie Haring Sweeney. Marilyn A. Fingerhut, Laurie Piacitelli, Kyle Steenland

EFFECTS OF TCDD ON THYROID METABOLISM IN US AIR FORCE HERBICIDESPRAYERS 347Marian Pavuk. Arnold J. Schecter, Fatema Z. Akhtar, Joel E. Michalek

THE INFLUENCE OF AGE AND GENDER ON SERUM CONCENTRATIONS OFP,P'DDT, P,P'DDE AND THE DDT / DDE RATIO IN SUBJECTS WITH EXOCRINEPANCRETIC CANCER 351M Porta, E Zumeta. L Ruiz, M Jariod, N Malats, E Marco, A Carrato, FX Real, JO

Grimalt

ASSESSING UNCERTAINTY IN A TOXICOKINETIC MODEL FOR HUMANLIFETIME EXPOSURE TO TCDD 355Harald Heinzl and Lutz Edler

SERUM DIOXIN CONCENTRATIONS AND BREAST CANCER RISK IN THESEVESIO WOMEN'S HEALTH STUDY 359Marcella Warner. Brenda Eskenazi, Paolo Mocarelli, Pier Mario Gerthoux, Steven

Samuels, Larry Needham, Donald Patterson, Paolo Brambilla

THE DIOXIN POLLUTION AS A RISK OF DEVELOPMENT FEMALE BREASTCANCER. CHAPAEVSK STUDY, RUSSIA 361B. Revich, T. Ushakova, O. Sergeev,V. Zeilert

HEXACHLOROBENZENE (HCB) AND TOTAL POLYCHLORINATED BIPHENYLS(3PCBS) IN HUMAN BREAST LIPIDS AND BREAST CANCER RISK IN POLISHWOMEN 365Pawel Strucinski. Jan K. Ludwicki, Katarzyna Goralczyk, Bogdan Wojtyniak,

Wlodzimierz Olszewski, Brian Buckley, Katarzyna Czaja, Jozef Jethon, JoannaBaranska and Agnieszka Hernik

PERINATAL DIOXIN EXPOSURE AND THYROID FUNCTIONS AT FOLLOW-UPAFTER 7 - 1 2 YEARS: EVIDENCE FOR TRANSIENT EFFECTS ON THYROIDFUNCTIONS 369Gavin W. ten Tusscher. Adri Ilsen, Thomas Vulsma, Matthijs Westra, Johannes W. van

der Slikke, Kees Olie, Janna G. Koppe

PERINATAL DIOXIN EXPOSURE AND CYTOCHROME P-450 ACTIVITY ANDLIVER FUNCTIONS AT FOLLOW-UP AFTER 7 - 1 2 YEARS: EVIDENCE FORTRANSIENT EFFECTS ON LIVER FUNCTIONS 371Gavin W. ten Tusscher. Henk-Jan Guchelaar, Joost Koch, Adri Ilsen, Matthijs Westra,

Johannes W. van der Slikke, Frederik A. de Wolff, Kees Olie, Janna G. Koppe

THE PREVALENCE OF LEUKAEMIA IN THE CHILDREN OF AUSTRALIANVIETNAM VETERANS 373Paul Jelfs, Paul Magnus, Michelle McPherson, Phil Trickett and Keith Horsley

INDICES OF REPRODUCTIVE HEALTH OF MALE POPULATION IN THEINCREASED RISK ZONES OF DIOXIN EXPOSITION 377Shamil Galimov, Zarema Amirova. Edward Kruglov, Felix Kamilov, Elmira Galimova

A STUDY ON PCDD AND PCDF CONTAMINATION IN A CASE OF PUBLICCONCERN 381Luigi Turrio-Baldassarri. Chiara Laura Battistelli, Alessandro di Domenico, Anna Laura

Iamiceli, Nicola Iacovella, Paolo Mazzoli, Gaetano Settimo, Giuseppe Viviano

A CASE-COHORT STUDY OF CRYPTORCHIDISM, HYPOSPADIAS ANDDELAYED SEXUAL MATURATION IN A DIOXIN CONTAMINATED REGION:CHAPAEVSK, RUSSIA 385Oleg Sergeyev. Boris Revich, Paige Williams, Susan Korrick, Vladimir Zeilert, Mary

M. Lee, Tatiana Ushakova, Igor Saharov, Larisa Altshul and Russ Hauser

EFFECTS OF PERINATAL EXPOSURE TO ENVIRONMENTALLY PERSISTENTORGANIC POLLUTANTS AND HEAVY METALS ON NEUROBEHAVIORALDEVELOPMENT IN JAPANESE CHILDREN: II. PROTOCOL AND DESCRIPTIONOF STUDY COHORT 389Kunihiko Nakai. Tomoko Oka, Keita Suzuki, Kunihiro Okamura, Toru Hosokawa,

Takeo Sakai, Tomoyuki Nakamura, Hiroyuki Takahashi, Hiroshi Satoh.

ANALYSIS OF SEX RATIOS FROM SEVESO AND RANCH HAND COHORTSUSING BINOMIAL PROBABILITY 391John M. Warmerdam and Jessica F. Greene

SEMEN QUALITY AND SERUM ORGANOCHLORINE LEVELS 395Susan Korrick, Larisa Altshul. Boris Revich, Tsiliya Bobovnikova, Galina Chernik

Quality in POPs analysis

DETERMINATION OF CONSENSUS VALUES IN INTERLABORATORYCOMPARISON STUDIES ON LEVELS OF DIOXINS IN LOW CONTAMINATEDFOOD SAMPLES 399CathrineThomsen. Line Smastuen Haug, Tove Nicolaysen, GunillaLindstrom, Georg

Becher

ISO 17025 REQUIREMENTS: HOW TO EVALUATE UNCERTAINTY FOR DIOXINANALYSIS IN FOOD AND FEED FROM VALIDATION DATA? 403Gauthier Eppe and Edwin de Pauw

ARE TARGET DIOXIN LEVELS IN ANIMAL FEEDINGSTUFFS ACHIEVABLEFOR LABORATORIES IN TERMS OF ANALYTICAL REQUIREMENTS?RESULTS OF AN INTERLAB ORATORY STUDY 407Gauthier Eppe and Edwin de Pauw

AVERAGE METHOD BLANK QUANTITIES OF DIOXIN-LIKE CONGENERSAND THEIR RELATIONSHIP TO THE DETECTION LIMITS OF THE U.S. ERA'SNATIONAL DIOXIN AIR MONITORING NETWORK (NDAMN) 411Christian Byrne, Joseph Ferrario, David H. Cleverly, Dwain Winters and Aubry Dupuy

DETERMINATION OF PCBS IN TRANSFORMER OIL AND CHEMICALLYDEGRADED OIL BY ISOTOPE DILUTION METHOD WITH HRGC/MS:3-LAB INTERCALIBRATION STUDY AND EVALUATION OF NEWCALIBRATION PCB MIXTURE 415Takumi Takasuga. Tohru Matsumura, Ken Shiozaki, Shin-ichi Sakai

QUALITY ASSURANCE CONSIDERATIONS FOR AN AMBIENT DIOXINMONITORING NETWORK 419Karen B. Riggs. David H. Cleverly, Joseph Ferrario, Pamela A. Hartford and Darrell

W. Joseph

UNCERTAINTY OF DIOXINS ANALYSIS BY JIS(JAPANESE INDUSTRIALSTANDARD) METHOD 423Hiroaki Mochizuki. Katsunori Motohashi, Shouzou Asada, Kensei Ehara

RESULT FROM THE SECOND ROUND OF THE KOREA CALIBRATION STUDYOF PCDDS/FS : INCINERATION EXTRACT/SOIL 427Chang Han Joo. Seok Won Eom, Jong Chan Kim, Byoung Eog Kim, Chang Ho Yim,

Yoon Seok Chang

The Ah Receptor and AhR mechanism of action

NEW INSIGHTS INTO THE STRUCTURE OF THE MAHR LIGAND BINDINGDOMAIN 429Laura Bonati. Alessandro Pandini, Demetrio Pitea, Yujuan Song and Michael S. Denison

ENDOGENOUS LIGANDS OF ARYLHYDROCARBON RECEPTOR ANDINTERACTION WITH DIOXINS 433Jun Sekizawa and Tomonari Matsuda

ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR BY1-BENZYLIMIDAZOLE: A NON-COPLANAR COMPOUND 437Jose Maria Navas. Antonio Chana, Bernardo Herraddn, Helmut Segner

NF-KB IS INVOLVED IN CROSS-TALK BETWEEN AH-RECEPTOR AND SIGNALTRANSDUCTION PATHWAYS 441Elaine M. Khan and Michael S. Denison

ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR BY DIOXININDUCES CELL CYCLE ARREST 445Alvaro Puga, Jennifer Marlowe, Xaoqing Chang and Alvaro Puga

CHARACTERIZATION OF REGULATORY ELEMENTS IN THE HUMAN AHRECEPTOR PROMOTER 449Judith Racky. Hans-Joachim Schmitz and Dieter Schrenk

AH-RECEPTOR-MEDIATED INDUCTION OF DRUG-METABOLIZING ENZYMESBY INDIRUBIN AND INDIGO 453Kazumi Sugihara, Tsuyoshi Yamada, Shigeyuki Kitamura, Shigeru Ohta, Keisuke

Yamashita, Saori Okamura, Mineo Yasuda, Yoshiaki Fujii-Kuriyama, Ken'ich Saeki,Saburo Matsui and Tomonari Matsuda

SEXUAL DIFFERENCE IN EFFECTS OF DIOXINS ON THYROID HORMONESYSTEM IN JAPANESE INFANTS 455Junva Nagayama. Takao Iida, Hironori Hirakawa, Takahiko Matsueda, Hiroshi Tsuji,

Jun'ichiro Fukushige and Tadayoshi Watanabe