curcumin extreme™ julian blumenfeld, md chief medical officer market america & nutrametrix...
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Curcumin Extreme™Curcumin Extreme™
Julian Blumenfeld, MDChief Medical Officer
Market America & nutraMetrix
Curcumin Extreme™Code: 13145 and 13145NM
• Curcumin (BCM-95®): 400 mg• Broccoli Seed Extract (6% Glucosinolates): 167 mg• Selenium (Selenomethionine): 100 mcg
Curcumin Extreme™Curcumin Extreme™
CurcuminCurcumin•Turmeric root extract
•3 major curcuminoids
•Curcumin
•Demethoxycurcumin
•Bis-demethoxycurcumin
• Powerful antioxidant
• Promotes normal activity of NF-kappaB
• Promotes normal cell cycle activity, normal cellular regeneration
• Promotes neurological health, helps to maintain neurological health as we age
Curcumin: Biological ActivitiesCurcumin: Biological Activities
•Reduces superoxide anions•Reduces peroxides•Inhibits LDL oxidation and lipid peroxidation
• Powerful antioxidant
• Promotes normal activity of NF-kappaB
• Promotes normal cell cycle activity, normal cellular regeneration
• Promotes neurological health, helps to maintain neurological health as we age
Curcumin: Biological ActivitiesCurcumin: Biological Activities
In unhealthy cells, curcumin has been shown to interfere with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E) and apoptosis.
-Anand, P., et al. Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Letters. 267: 133-164, 2008.
Curcumin: Biological ActivitiesCurcumin: Biological Activities
• Powerful antioxidant
• Promotes normal activity of NF-kappaB
• Promotes normal cell cycle activity, normal cellular regeneration
• Promotes neurological health, helps to maintain neurological health as we age
Curcumin: Biological ActivitiesCurcumin: Biological Activities
Curcumin can cross the blood-brain barrier and bind directly to amyloid plaques and increase the uptake of amyloid-β protein by macrophages.
-Zhang, L., et al. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer’s disease patients. Journal of Alzheimer’s Disease. 10: 1-7, 2006.
Curcumin: Curcumin: The BCM-95The BCM-95®® Difference Difference
Broccoli Seed ExtractBroccoli Seed Extract (6% Glucosinolates)(6% Glucosinolates)
• Promotes the normal production of detoxification enzymes
• Helps maintain healthy glutathione levels
• Promotes apoptosis in unhealthy cells
• Promotes a strong immune systemkeap1m
keap1m keap1c
keap1cSH
SH
HS
HS
ARE
nrf2
Nucleus
Cytosol
GST’s, GR, GPx, HO-1
• Promotes the normal production of detoxification enzymes
• Helps maintain healthy glutathione levels
• Promotes apoptosis in unhealthy cells
• Promotes a strong immune system– Enhance total white blood cell count– Enhance phagocytic activity
– Reduced elevated TNFα from LPS stimulated macrophages
Broccoli Seed Extract (6% Glucosinolates)Broccoli Seed Extract (6% Glucosinolates)
-Thejass, P. and Kuttan, G. Immunomodulatory activity of sulforaphane, a naturally occuring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine. 14: 538-545, 2006.
Selenium (Selenomethionine)• Required cofactor for selenoproteins
– Glutathione peroxidase enzymes
– Iodothyronine deiodinase enzymesThyroxine (T4) Thyroid Hormone (T3)
-Brown, K. and Arthur, J. Selenium, selenoproteins and human health: a review. Public Health Nutrition. 4: 593-599, 2001.
O OH H
Glutathione
Glutathione
H
H H
H
Directions: Take one capsule per day, with or without a meal.
Warning: If you are currently taking warfarin (Coumadin) or other anti-platelet/anti-coagulant medications, you should not take this product. If you are taking any other prescription drugs or have an ongoing medical condition, you should consult your physician before using this product. Women who are pregnant or nursing should not take this product.
Curcumin Extreme™Curcumin Extreme™
SummarySummary• Curcumin Extreme™
– Curcumin (BCM-95®): 400 mg– Broccoli Seed Extract (6% Glucosinolates): 167 mg– Selenium (Selenomethionine): 100 mcg
• Why curcumin? Why now?
• Who would benefit?
Curcumin Extreme™Code: 13145 and 13145NMDC: $28.50SR: $39.95BV: 23
