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Curriculum Vitae

David G. Harrison

Business Address: 2220 Pierce Avenue, Room 536 RRB

Nashville, TN 37232-6602 Business Phone: (615) 875-3049

Cell Phone: (404) 290-0904 Fax: (615) 875-3297

E-mail: david.g.harrison@vanderbilt.edu EDUCATION: Undergraduate: Oklahoma State University, 1966-1970 Medical School: Oklahoma University School of Medicine 1970-1974 TRAINING:

1974-75 Medical Internship Duke Hospital, Durham, NC James Wyngaarden (Chairman) 1975-77 Medical Residency Duke Hospital, Durham, NC James Wyngaarden (Chairman) 1977-79 Cardiology Fellow Duke University Medical Center, Durham, NC James Wyngaarden (Chairman) 1980-82 Cardiovascular Cardiovascular Center, University of Iowa, Research Fellowship University of Iowa, Iowa City, Iowa

Francois M. Abboud (Chairman) LICENSURE/CERTIFICATION: State of Georgia Medical License, # 033348

State of Tennessee Medical License # 46911 Certified in Internal Medicine, 1977 #62864

Certified in Cardiovascular Diseases, 1979 # 62864 ACADEMIC APPOINTMENTS: Betty and Jack Bailey Professor of Medicine Director, Division of Clinical Pharmacology Vanderbilt University School of Medicine HOSPITAL APPOINTMENTS: Vanderbilt University Hospital and Medical Center OTHER EMPLOYMENT: (optional) None HONORS AND AWARDS: 1974 Alpha Omega Alpha, University of Oklahoma 1974 Benjamin Rush Award for Outstanding Student in Psychiatry, University of Oklahoma 1977 Haskel Schiff Award for Outstanding Medical House Officer, Duke University Department of

Medicine 1980 Outstanding Attending, Department of Medicine Charlotte Memorial Hospital 1980 Individual National Research Service Award, National Institute of Health 1981 Clinical Investigator Award, NIH, August 1982 - July 1987 1981 Clinician Scientist Award, American Heart Association (Awarded, but not accepted) 1987-92 Established Investigator, American Heart Association 1995 George E. Brown Memorial Lecture, American Heart Association Scientific Sessions 1998 Wellcome Visiting Professor in the Basic Medical Sciences, New York Medical College, May 10,

1998 2001 Pfizer Visiting Professorship, Temple University, Philadelphia

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February 14-16, 2001 2001 Robert Furchgott Lecture for the 8th Symposium on Mechanisms of Vasodilatation, Boston, Massachusetts 2001 Bernard Marcus Chair of Cardiovascular Medicine

2002 Robert M. Berne Award for Cardiovascular Research, Cardiovascular Section, American Physiological Society

2002 Sir George Pickering Lecture, British Hypertension Society Annual Scientific Meeting, Queens’ College, Cambridge, UK, September 2002

2003 2003 Distinguished Achievement Award (AHA Council on Basic Sciences) 2004 J. Willis Hurst Internal Medicine Residency Program Mentorship Award 2004 Novartis Award for Hypertension Research, American Heart Association Council of High Blood

Pressure 2008 Outstanding Basic Science Research Citation Award, Emory University Department of Medicine 2010 Carl J. Wiggers Award, Cardiovascular Section, American Physiological Society 2010 Distinguished Scientist Award, American Heart Association 2012 Distinguished Scientist Award, American Society of Hypertension 2013 Fellow, American Association for the Advancement of Science

PROFESSIONAL ORGANIZATIONS: 1985 Member, Central Society for Clinical Research 1984 Member, American Federation of Clinical Research, Midwest Section 1987 Member, American Physiological Society 1988 Fellow, Cardiovascular Section, American Physiological Society 1992 Member, American Society for Clinical Investigation 1993 Member, Society for Vascular Medicine and Biology

1994 Member, American Association of University Cardiologists 1996 Member, Oxygen Society 2001 Fellow, Basic Science Council, American Heart Association 2002 Fellow, American College of Cardiology 2002 Member, Association of American Physician 2012 Fellow, American Association for the Advancement of Science 2012 Member, American Clinical and Climatological Association

PROFESSIONAL ACTIVITIES:

INSTITUTIONAL SERVICE 1983-84 Medical Student Advisory Committee, University of Iowa

1983-90 University Animal Care Committee, University of Iowa 1983-90 House Staff Advisory Committee, Dept. of Medicine, Univ. of Iowa 1986-90 House Staff Evaluation Committee, Dept. of Medicine, Univ. of Iowa 1986-1989 Service Chief, Veterans Administration Hospital, Iowa City, IA 1988-89 Promotions Committee, University of Iowa (to Associate Professor) 1997-2000 Service Chief, Veterans Administration Hospital, Atlanta, GA 1997 Committee for Research Planning, Emory Univ. Health Sciences Center 2000 Department of Medicine Research Strategic Planning Committee 2000-2009 Director, Division of Cardiology, Emory University

2002-2009 Heart Center Steering Committee, Emory Heart Center 2003-2004 Proteomics, Chemical and Structural Biology Strategic Planning Committee 2003-2009 Member, Governing Board for Carlyle Frazier Heart Center, Crawford Long Hospital 2011- Present Director, Division of Clinical Pharmacology, Vanderbilt University

2011-present Executive committee, Mouse physiology core facility, Vanderbilt University Medical Center 2011-Present Director, Vascular Biology Center, Vanderbilt University Medical Center

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2011-2012 Member – Biochemistry Chair search committee 2011-2012 Chair – Search committee for Oates Chair of Translational Research TEACHING (past and present) Medical Student Teaching: 1994-2010 Pathophysiology lectures on Endothelial function and dysfunction, Emory Medical School 1995-2009 Sophomore Electives, Emory University Hospital. 2001-2009 Director, Bench to Bedside, Cardiology Sophomore Clinical Methods, Emory University Hospital 1990-2010 Attending Physician, Cardiology Service, Atlanta VA Hospital, 2.5 months per year

2001-2010 Attending Physician, R. Bruce Logue Cardiology Service, Emory University Hospital, 2-3 months per year

2011-Present Attending Physician, Harrison Cardiology Service, Vanderbilt University, 1 month per year

Graduate Program: Training programs:

Faculty Member, Molecular and Systems Pharmacology Program, Emory University. 1992-2010 Lecture Series on nitric oxide/cGMP biology to MSP graduate students every other year Emory University

2011 – present: Member Pharmacology faculty and mentor, Vanderbilt University 2013- present: Member Molecular Physiology and Biophysics faculty and mentor, Vanderbilt University

TRAINEES a. Ph.D. students directly supervised:

Years in Name Current position/Institution Training 1995-1998 Steven Presnell, Ph.D. Research Associate, Univ. of Kentucky Medical Center,

Department of Pathology 1998-2003 Linda Cai, M.D., Ph.D., Professor, UCLA 1999-2003 Michael E. Davis, Ph.D., Associate Professor, Emory University 2002-2005 Scott McNally, M.D., Ph.D Assistant Professor, University of Utah 2003-2008 Nyssa E. Hoch, Ph.D Medical Writer, San Francisco, CA 2006- 2011 Li Li Life Sciences Specialist, L.E.K. Consulting 2010 – present Jing Wu 2013 – present Allison Norlander 2013 – present Roxana Loprena

b. Post-doctoral fellows directly supervised:

Years in Training Name Current position/Institution 1984-1987 Paul Freiman, MD Cardiologist, Private Practice 1985-1986 Gordon Mitchell, MD Cardiologist, Private Practice 1985-1987 Darrel C. Gumm, MD Cardiologist, Private Practice 1986-1989 Rich Guerra, MD Cardiologist, Private Practice 1987-1988 Peter Banitt, MD Cardiologist, Private Practice 1987-1989 R. Paul Myers, MD, PhD Cardiologist, Private Practice 1988-1989 Frank Sellke, MD, Professor and Director Cardiothoracic Surgery, Brown University 1988-1990 Kevin Peters, M.D. Chief Scientific Officer and VP Research and Development, Akebia Therapeutics

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1989-1990 James Quillen, MD Cardiologist, Private Practice 1989-1990 Rob Minor, MD Cardiologist, Private Practice 1989-1990 Maurizio Cappelli-Bigazzi, MD Specialist, Pediatric Cardiology, University of Naples 1990-1992 Robert M. Wheatley, MD Cardiologist, Private Practice 1991-1993 Jorge Navas, MD Cardiologist, Private Practice 1991-1995 Yuichi Ohara, MD Assistant Professor, Kyushu University 1992-1995 Hassan S. Sayegh, MD Cardiologist, Private Practice 1993-1995 Natalie James, PhD Research Scientist, Ventassist Corporation, Australia 1993-1995 Thomas Münzel, MD Professor and Director of Cardiology, University of Mainz, Germany 1993-1995 Richard Venema, Ph.D Professor of Pharmacology and Toxicology, Georgia Health

Sciences University 1993-1995 Nobutaka Inoue, MD Professor, Kobe University 1993-1994 Jean-Francois Arnal, MD, PhD Faculty, INSERM, France 1994-1996 Sanjay Rajagopalan, MD Professor of Medicine and Radiology, Ohio State University 1994-1996 Sabine Kurz, MD Cardiologist, Private Practice 1995-1996 Georg Kojda, PhD Faculty Member, Pharmacology Department, Univ. of Dusseldorf, Germany 1995-1996 Jørn-Bech Laursen, MD Cardiologist, Private Practice, Denmark 1995-1999 Tohru Fukai, MD Associate Professor of Medicine and Pharmacology, University of Illinois Chicago 1995-1999 Jonathan D. Kent, PhD Research Scientist, Bayer Pharma 1995-1997 Charles Searles, MD Assistant Professor, Emory University 1996-1997 Ascan Warnholtz, MD Cardiologist, University of Mainz 1996-1999 Mark Somers, MD Cardiologist, Private Practice 1997-1999 Martin Siegfried, MD Cardiologist, Private Practice 1997-1999 Grant Drummond, PhD NHMRC RD Associate Professor, Monash University, Australia 1997-2000 Yoichi Miwa, MD, PhD Physician, Kobe University 1998-2000 Hans Ulrich Hink, MD Cardiologist, University of Mainz 1998-2001 David Schultz, MD, PhD Cardiologist, Private Practice 1998-2003 Hua (Linda) Cai, MD, Ph.D. Associate Professor of Anesthesiology, Cardiovascular Research Laboratories, University of California at Los Angeles 2000-2002 Ulf Landmesser, MD Director of translational research, Klinik für Kardiologie, HerzKreislaufZentrum UniversitätsSpital, Zürich, Switzerland 2000-2002 Kenji Kanazawa, MD, PhD Physician, Kyushu University 2002-2003 Quinton Gradek, MD Cardiologist, Private Practice 2002-2004 Cornelius Mueller, M.D. Cardiologist, University of Bonn, Germany 2002-2004 Karine Laude, Ph.D. Faculti de Medicine-Pharmacie, France 2002-2004 Isabella Grumbach, M.D., Ph.D. Assistant Professor, University of Iowa 2003-2006 Julian Widder, M.D. 2nd Uberartz, Medizinische Hochschule Hannover, Germany 2004-2008 Wei Chen, Ph.D. Assistant Professor, Vanderbilt University 2005-2011 Maria Carolina Gongora Cardiology Fellow, Emory University 2005-2008 Tomasz Guzik, M.D., Ph.D Professor, University of Cracow, Poland Department Chairman, Internal Medicine 2005-2007 Kathryn Brown, Ph.D. Manager, Medical Affairs, Imedex 2007-2008 Petra Gratze, M.D. Cardiology Fellow, University of Berlin 2007-2009 Klaudia Budzyn, Ph.D. Post-doctoral fellowship, NHMRC 2008-2009 Thomas Jansen, M.D. Research Fellow, Karolinska Institute 2007-2010 Meena Madhur, M.D., Ph.D. Assistant Professor, Vanderbilt University 2008-2010 Antony Vinh, Ph.D. Faculty member, Monash University, Australia 2006-2011 Paul Marvar, Ph.D. Marie Curie International Research Fellow

School of Physiology & Pharmacology, Bristol Heart Institute, University of Bristol, England

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2006-2011 Heinrich Lob, Ph.D. Research Scientist, Cornell University 2008-2012 Salim Thabet, M.D. Cardiology Fellow, Emory University

Current Trainees Years in Laboratory Name Support

2010-Present Jing Wu (pre-doctoral) NIH 2011-Present Daniel Trott, Ph.D. NIH T32 training grant 2011-Present Annett Kirabo, DVM, PhD AHA Fellowship 2012-Present Mohamed Saleh, Ph.D. NIH 2012-Present Liang Xiao, Ph.D. NIH 2012-Present Hanaa Itani, Ph.D. NIH T32 training grant 2013-Present William McMaster, M.D. NIH T32 training grant 2013-Present Daniele Michell, PhD NIH 2013-Present Allison Norlander (pre-doctoral) NIH T32 training grant 2013-Present Roxanna Loperena (pre-doctoral) APS 2014-Present Kim Montaniel (pre-doctoral)

EXTRAMURAL ACTIVITIES National and International: 1982-1985 Iowa Affiliate Study Section, American Heart Association 1983-1988 Great Plains Regional Review Committee Study Section, AHA

1987-1988 Chairman, Great Plains Regional Review Committee Study Section, American Heart Association

1987-1988 Committee for Regional and National Research, AHA 1987-1990 National Review Committee Study Section, AHA 1990-1994 VA Merit Review, Cardiovascular Study Section 1991-1992 Chairman, VA Merit Review Cardiovascular Study Section 1991-1994 Vascular Wall Biology Study Section, American Heart Association 1992-1994 Chairman, Credentials Committee, Council on Circulation, AHA 1992-1995 National Study Section on Vascular Biology, AHA

1992-1997 Member, Experimental Cardiovascular Sciences Study Section, Division of Research Grants, National Institutes of Health

1993-1995 Chairman, Scientific Conference Planning Committee, AHA 1993-1995 Chairman, Marcus Selection Committee, AHA 1993-1995 Member, Executive Committee, Council on Circulation, AHA 1994-1997 Chairman, Experimental Cardiovascular Sciences Study Section,

Division of Research Grants, National Institutes of Health 1995-1998 Vice Chairman, Executive Committee, Council on Circulation, AHA 1998-1999 Chairman, Executive Committee, Council on Circulation, AHA 1999-2000 Program Committee, Council Basic Cardiovascular Sciences, AHA 2000-2001 Member, American Heart Association Research Planning and

Evaluation Committee 2002-2004 Member, American Heart Association Research Committee 2005-present Member, Novartis Award Selection Committee of the Council for High Blood Pressure

Research (AHA) 2010 Organizer and Chair, American Physiological Conference on Inflammation, Immunity and

Cardiovascular Disease 2011 Organizer and Chair, North American Vascular Biology Organization. Session on

Immunology and Vascular Biology 2011-2012 Organizer, Vasculata Conference of North American Vascular Biology Organization 2012-2014 Chair – Research program for American Society of Hypertension 2014 Chair – Distinguished Scientist Award Selection Committee for American Society of

Hypertension 2014 Chair, NHLBI Workshop on Salt, Immunity and Hypertension

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Consultantships: External Advisory Committee - Louisiana State University COBRE grant. External Advisory Committee – T32 Training Grant, University of Alabama Birmingham External Advisory Committee – T32 Training Grant, Physiology University of Virginia Other administrative appointments:

Organizer, American Heart Association Winter Conference on Vascular Biology, 1992 Organizer, American Heart Association Winter Conference on Vascular Biology, 1995 American Heart Association Scientific Sessions Planning Committee, 1998 Chair, Basic Cardiovascular Research Council, American Heart Association, 1997-1998 Secretary/Treasurer, Association of University Cardiologists 2003-2006

Vice President, Association of University Cardiologists 2006-2007 President, Association of University Cardiologists, 2007-2008 Organizer and Chair, Inflammation, Immunity and Cardiovascular Disease Symposium, American Physiological Society, 2008-2010. Meeting Held August 2010 Co-chair for Basic Pathophysiology, American Society of Hypertension Meeting, May 2011. Chair and Organizer, Vascular Inflammation and Immunity Session. North American Vascular Biology Organization Symposium. October 2011 Chair and Organizer, Vasculata Conference held in Nashville, TN July 2012

Patents: US patent #5498539, “Endothelial Nitric Oxide Synthase,” Issued: 3/12/96,

EDITORIAL RESPONSIBILITIES

Editorships and Editorial Boards: 1990-1994 Editorial Board, Circulation 1991-present Editorial Board, Journal of Cardiovascular Pharmacology 1992-1993 Editorial Board, Trends in Cardiovascular Medicine 1992-1996 Editorial Board, Endothelium 1993-1998 Editorial Board, Journal of Vascular Medicine and Biology 1995-present Editorial Board, Circulation Research 1997-2006 Editorial Board, Journal of Clinical Investigation 1999-present Editorial Board, Arteriosclerosis, Thrombosis, and Vascular Biology 2000-present Editorial Board, Hypertension 2005-2008 Editorial Board, Circulation 2005-2010 Editorial Board, Journal of the CardioMetabolic Syndrome 2010-present Editorial Board, American Journal of Physiology, Renal physiology

Manuscript reviewer:

1982-present Circulation 1984-present American Journal of Physiology 1984-present Circulation Research 1988-present Journal of American College of Cardiology 1988-present Journal of Clinical Investigation

1990-present Journal of Pharmacological Exp. Therapeutics 1990-present Journal of Cardiovascular Pharmacology 1992-present Trends in Cardiovascular Medicine 1992-present Endothelium 1992-present Arteriosclerosis, Thrombosis, and Vascular Biology 1992-present American Journal of Medical Sciences 1992-present Journal of Cardiovascular Pharmacology 1992-present Nature

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1993-present Journal of Biological Chemistry 1993-1998 Journal of Vascular Medicine and Biology 1993-present American Journal of Cardiology 1995-present Proceedings of the National Academy of Sciences, USA 1996-present Molecular Pharmacology 1996-present Biochemical Pharmacology 1997-present Diabetes 1997-present Journal of Cell Physiology 1998-present Journal of Free Radicals in Medicine and Biology 2000-present Nature Medicine 2008-Present Atherosclerosis 2009-Present Lab Investigation 2011-Present Blood

GRANT AWARDS:

1. Principal Investigator; NIH R01 HL39006-24; Immunity, Inflammation and Hypertension; $325,000/yr; 08/01/87 to 11/31/2017. (Funded since 1997).

2. Principal Investigator, American Heart Association Strategically Focused Research Network; $750,000/year.

Basic Science Project Director, Meena Madhur Co-Director; $250,000/year.

3. Project Director, NIH P01 GM015431-46, Research Center for Pharmacology & Drug Toxicology. Principal investigator: L. Jackson Roberts. Project 4 – Therapeutic Modulation of Endothelial Cell Tetrahydrobiopterin. Period: 07/01/2011-06/31/2016. $250,000/year.

4. Co-Principal Investigator, NIH 1R01HL108701-01, Vascular Oxidative Stress in Obesity. Multi-investigator grant with Hua Cai, UCLA Medical School. Period 2/24/12 – 12/31/2015. Total project $499,562/year. Funding to Dr. Harrison $250,000

5. Co-Investigator, NIH Vascular Interventions and Therapeutic Advances. Period 1/1/14 -12/30/17. Total project $250,000 per year

6. Principal Investigator, Bristol Meyers Squibb industry grant; Use of Abatacept to Treat Patients with Resistant Hypertension. 5/1/14 – 4/30/16. Total project $375,000

Past Awards:

1. Veterans Administration Merit Award, 1984-2009. 2. Collaborating Investigator, NIH BAA-HV-10-08 Program of Excellence in Nanotechnology (PEN): Center for

Translational Cardiovascular Nanomedicine. $30,000/yr (Salary support). Principal Investigator Gang Bao

3. Collaborating Investigator, NIH R01DA030996-01 Cocaine, HIV/AIDS, and Antiretrovirals, $72,968/yr. (salary and post-doctoral support). Principal Investigator William Lewis

4. Principal Investigator & Preceptor; NIH; Research Training in Academic Cardiology; T32 HL07745; $495,092/yr (no salary); 7/1/04-12/3102010. (Funded since 1997)

PUBLICATIONS: A. Published and accepted research articles (clinical, basic science, other) in refereed journals: 1. Koyanagi S, Eastham CL, Harrison DG, Marcus ML. Transmural Variation in the Relationship Between Myocardial

Infarct Size and Risk Area. Am J Physiol 1982; 242:H867-874.

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2. Koyanagi S, Eastham CL, Harrison DG, Marcus ML. Increased Size of Myocardial Infarction in Dogs with Chronic Hypertension and Left Ventricular Hypertrophy. Circ Res 1982; 50:55-62.

3. Palmeri ST, Harrison DG, Cobb FR, Morris KG, Ideker RE, Harrell FE, Selvester RH, Wagner GS. A QRS Scoring

System for Assessing Left Ventricular Function After Myocardial Infarction. N Eng J Med 1982; 306:4-9. 4. Baker JT, Bramlet DA, Lester RM, Harrison DG, Roe CR, Cobb FR. Myocardial Infarct Extension: Incidence and

Relationship to Survival. Circulation1982; 65:918-923. 5. Anderson CI, Harrison DG, Stack NC, Hindman NB, Ideker RE, Palmeri ST, Selvester RH, Wagner GS. Evaluation of

Serial QRS Changes During Acute Inferior Myocardial Infarction Using a QRS Scoring System. Am J Cardiol 1983; 52:252-256.

6. Harrison DG, White CW, Hiratzka LF, Doty DB, Eastham CL, Marcus ML. The Value of Lesion Cross-Sectional Area

Determined by Quantitative Coronary Angiography in Assessing the Physiologic Significance of Proximal Left Anterior Descending Coronary Arterial Stenoses. Circulation 1984; 69:1111-1119.

7. Harrison DG, Ferguson DW, Collins SM, Skorton DJ, Ericksen EE, Kioschos JM, Marcus ML, White CW. Rethrombosis

After Reperfusion with Streptokinase: Importance of Geometry of Residual Lesions. Circulation 1984; 69:991-999. 8. White CW, Wright CB, Doty DB, Hiratzka LF, Eastham CL, Harrison DG, Marcus ML. Does Visual Interpretation of the

Coronary Arteriogram Predict the Physiologic Importance of a Coronary Stenosis? N Engl J Med 1984; 310:819-824. 9. Harrison DG, Barnes DH, Hiratzka LF, Eastham CL, Kerber RE, Marcus ML. The Effect of Cardiac Hypertrophy on the

Coronary Collateral Circulation. Circulation 1985; 71:1135-1145. 10. Roberts N, Harrison DG, Reimer KA, Crain BS, Wagner GS. Right Ventricular Infarction with Shock but Without

Significant Left Ventricular Infarction: A New Clinical Syndrome. Am Heart J 1985; 110:1047-1053. 11. Chilian WM, Harrison DG, Haws CW, Snyder WD, Marcus ML. Adrenergic Coronary Tone During Submaximal

Exercise in the Dog is Produced by Circulating Catecholamines: Evidence for Adrenergic Denervation Supersensitivity in the Myocardium But Not in Coronary Vessels. Circ Res 1986; 58:68-82.

12. Harrison DG, Chilian WM, Marcus ML. Absence of Functioning �-Adrenergic Receptors in Mature Canine Coronary

Collaterals. Circ Res 1986; 59:133-142. 13. Freiman PC, Mitchell GG, Heistad DD, Armstrong ML, Harrison DG. Atherosclerosis Impairs Endothelium-Dependent

Vascular Relaxation to Acetylcholine and Thrombin in Primates. Circ Res 1986; 58:783-789. 14. Harrison DG, Chapman MP, Christy JP, Marcus ML. Studies of Functional Site of Origin of Native Coronary Collaterals.

Am J Physiol 1986; 251:H1217-1224. 15. Johnson MR, Brayden GP, Ericksen EE, Collins SM, Skorton DJ, Harrison DG, Marcus ML, White CW. Changes in

Cross-Sectional Area of the Coronary Lumen in the Six Months After Angioplasty: A Quantitative Analysis of the Variable Response to Percutaneous Transluminal Angioplasty. Circulation 1986; 73:467-475.

16. Marcus ML, Harrison DG, Chilian WM, Koyanagi S, Inou T, Tomanek RJ, Martins JB, Eastham CL, Hiratzka LF.

Alterations in the Coronary Circulation in Hypertrophied Ventricles. Circulation 1987; 75:I19-25. 17. Harrison DG, Armstrong ML, Freiman PC, Heistad DD. Restoration of Endothelium-Dependent Relaxation by Dietary

Treatment of Atherosclerosis. J Clin Invest 1987; 80:1808-1811. 18. Harrison DG, Freiman PC, Armstrong ML, Marcus ML, Heistad DD. Alterations of Vascular Reactivity in

Atherosclerosis. Circ Res 1987; 61:II74-80. 19. Inou T, Lamberth WC Jr, Koyanagi S, Harrison DG, Eastham CL, Marcus ML. Relative Importance of Hypertension

After Coronary Occlusion in Chronic Hypertensive Dogs with LVH. Am J Physiol 1987; 253:H1148-158.

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20. Heistad DD, Harrison DG, Armstrong ML. Serotonin and Experimental Vascular Disease. Int J Cardiol 1987; 14:205-

212. 21. Gumm DC, Cooper SM, Thompson SB, Marcus ML, Harrison DG. Influence of Risk Area Size and Location on Native

Collateral Resistance and Ischemic Zone Perfusion. Am J Physiol 1988; 254:H473-480. 22. Harrison DG, Florentine MS, Brooks LA, Cooper SM, Marcus ML. The Effect of Hypertension and Left Ventricular

Hypertrophy on the Lower Range of Coronary Autoregulation. Circulation 1988; 77:1108-1115.

23. Lopez JA, Armstrong ML, Harrison DG, Piegors DJ, Heistad DD. Responsiveness of Iliac Collateral Vessels to Constrictor Stimuli in Atherosclerotic Primates. Circ Res 1988; 63:1020-1028.

24. Peters KG, Marcus ML, Harrison DG. Vasopressin and the Mature Coronary Collateral Circulation. Circulation 1989;

79:1324-1331. 25. Myers PR, Guerra R Jr, Harrison DG. Release of NO and EDRF from Cultured Bovine Aortic Endothelial Cells. Am J

Physiol 1989; 256:H1030-1037. 26. Myers PR, Banitt PF, Guerra R Jr, Harrison DG. Characteristics of Canine Coronary Resistance Arteries: Importance of

the Endothelium. Am J Physiol 1989; 257:H603-610. 27. Feldman RD, Christy JP, Paul ST, Harrison DG. ß-Adrenergic Receptors on Canine Coronary Collateral Vessels:

Characterization and Function. Am J Physiol 1989;257:H1634-1639. 28. Guerra R Jr, Brotherton AFA, Goodwin PJ, Clark CR, Armstrong ML, Harrison DG. Mechanisms of Abnormal

Endothelium-dependent Vascular Relaxation in Atherosclerosis: Implications for Altered Autocrine and Paracrine Functions of EDRF. Blood Vessels 1989; 26:300-314.

29. Tomanek RJ, Schalk KA, Marcus ML, Harrison DG. Coronary Angiogenesis During Long-Term Hypertension and Left

Ventricular Hypertrophy in Dogs. Circ Res 1989; 65:352-359. 30. Lopez JA, Armstrong ML, Harrison DG, Piegors DJ, Heistad DD. Vascular Responses to Leukocyte Products in

Atherosclerotic Primates. Circ Res 1989; 65:1078-1086. 31. Sellke FW, Myers PR, Bates JN, Harrison DG. Influence of Vessel Size on the Sensitivity of Porcine Microvessels to

Nitroglycerin. Am J Physiol 1990; 258:H515-520. 32. Sellke FW, Armstrong ML, Harrison DG. Endothelium-Dependent Vascular Relaxation is Abnormal in the Coronary

Microcirculation of Atherosclerotic Primates. Circulation 1990; 81:1586-1593. 33. Sellke FW, Quillen JE, Brooks LA, Harrison DG. Endothelial Modulation of the Coronary Vasculature in Vessels

Perfused Via Mature Collaterals. Circulation 1990; 81:1938-1947. 34. Sellke FW, Myers PR, Bates JN, Harrison DG. Influence of Vessel Size on the Sensitivity of Porcine Microvessels to

Nitroglycerin. Am J Physiol 1990; 258:H515-20. 35. Myers PR, Minor RL Jr, Guerra R Jr, Bates JN, Harrison DG. Vasorelaxant Properties of the Endothelium-Derived

Relaxing Factor More Closely Resemble S-Nitrosocysteine than Nitric Oxide. Nature 1990; 345:161-163. 36. Murphy S, Minor RL Jr, Welk G, Harrison DG. Evidence for an Astrocyte-Derived Vasorelaxing Factor with Properties

Similar to Nitric Oxide. J Neurochem 1990; 55:349-351. 37. Cappelli-Bigazzi M, Lamping KG, Nuno DW, Harrison DG. Leukocyte and Platelet-Derived Factors Augment Canine

Coronary Constriction to Serotonin. Am J Physiol 1990; 259:H1161-170.

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38. Quillen JE, Sellke FW, Brooks LA, Harrison DG. Ischemia-Reperfusion Impairs Endothelium-Dependent Relaxation of Coronary Microvessels but Does Not Affect Large Arteries. Circulation 1990; 82:586-594.

39. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, Harrison DG. Diet-Induced Atherosclerosis Increases the Release of

Nitrogen Oxides from Rabbit Aorta. J Clin Invest 1990; 86:2109-2116. 40. Mügge A, Harrison DG. L-Arginine Does Not Restore Endothelial Dysfunction in Atherosclerotic Rabbit Aorta In Vitro.

Blood Vessels 1991; 28:354-357. 41. Myers PR, Banitt PF, Guerra R Jr, Harrison DG. Role of the Endothelium in Modulation of the Acetylcholine

Vasoconstrictor Response in Porcine Coronary Microvessels. Cardiovasc Res 1991; 25:129-137. 42. Rubanyi G, Johns, Wilcox D, Bates JN, Harrison DG. Evidence That a S-Nitrosothiol, But Not Nitric Oxide, may be

Identical with Endothelium-Derived Relaxing Factor. J Cardiovasc Pharmacol 1991; 17:S41-S45. 43. Mügge A, Elwell JH, Peterson TE, Harrison DG. Release of Intact Endothelium-Derived Relaxing Factor Depends on

Endothelial Superoxide Dismutase Activity. Am J Physiol 1991; 260:C219-225. 44. Kurz MA, Lamping KG, Bates JN, Eastham CL, Marcus ML, Harrison DG. Mechanisms Responsible for the

Heterogeneous Coronary Microvascular Response to Nitroglycerin. Circ Res 1991; 68:847-855. 45. Mügge A, Peterson TE, Harrison DG. Release of Nitrogen Oxides from Cultured Bovine Endothelial Cells Is Not

Impaired by Calcium Channel Antagonists. Circulation 1991; 83:1404-1409. 46. Harrison DG, Treasure CB, Mügge A, Dellsperger KC, Lamping KG. Hypertension and the Coronary Circulation. With

Special Attention to Endothelial Regulation. Am J Hypertens 1991; 4:454S-459S. 47. Harrison DG, Marcus ML, Dellsperger KC, Lamping KG, Tomanek RJ: Pathophysiology of Myocardial Perfusion in

Hypertension. Circulation 1991; 83:III14-18 48. Sellke FW, Tomanek RJ, Harrison DG. L-Cysteine Selectively Potentiates Nitroglycerin-Induced Dilation of Small

Coronary Microvessels. J Pharmacol Exp Ther 1991; 258:365-369. 49. Bates JN, Harrison DG, Myers PR, Minor RL. EDRF Nitrosylated Compound or Authentic Nitric Oxide. Basic Res

Cardiol 1991; 86:17-26. 50. Tomanek RJ, Wessel TJ, Harrison DG. Capillary Growth and Geometry During Long-Term Hypertension and

Myocardial Hypertrophy in Dogs. Am J Physiol 1991; 261:H1011-8. 51. Bates JN, Baker MT, Guerra R Jr, Harrison DG. Nitric Oxide Generation from Nitroprusside by Vascular Tissue.

Evidence that Reduction of the Nitroprusside Anion and Cyanide Loss are Required. Biochem Pharmacol 1991; 42:S157-165.

52. Mügge A, Elwell JH, Peterson TE, Hofmeyer TG, Heistad DD, Harrison DG. Chronic Treatment with Polyethylene-

Glycolated Superoxide Dismutase Partially Restores Endothelium-Dependent Vascular Relaxations in Cholesterol-Fed Rabbits. Circ Res 1991; 69:1293-1300.

53. Komaru T, Lamping KG, Eastham CL, Harrison DG, Marcus ML, Dellsperger KC. Effect of an Arginine Analogue on

Acetylcholine-Induced Coronary Microvascular Dilation in Dogs. Am J Physiol 1991; 261:H2001-2007. 54. Quillen JE, Sellke FW, Armstrong ML, Harrison DG. Long-Term Cholesterol Feeding Alters the Reactivity of Primate

Coronary Microvessels to Platelet Products. Arterioscler Thromb Vasc Biol 1991; 11:639-644. 55. Murphy S, Minor RL Jr, Welk G, Harrison DG. Central Nervous System Astroglial Cells Release Nitrogen Oxide(s) with

Vasorelaxant Properties. J Cardiovasc Pharm 1991; 17:S265-S268. 56. Harrison DG, Simonetti I: Neurohumoral Regulation of Collateral Perfusion. Circulation 1991; 83:III62-III67

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57. Quillen JE, Sellke FW, Banitt P, Harrison DG. The Effect of Norepinephrine on the Coronary Microcirculation. J Vasc

Res 1992; 29:2-7. 58. Harrison DG. Kurz MA. Quillen JE. Sellke FW. Mugge A: Normal and pathophysiologic considerations of endothelial

regulation of vascular tone and their relevance to nitrate therapy. Am J Cardiol 1992; 70:11B-17B. 59. Quillen JE, Harrison DG. Vasomotor Properties of Porcine Endocardial and Epicardial Microvessels. Am J Physiol 1992;

262:H1143-1148. 60. Fuji M, Nuno DW, Lamping KG, Dellsperger KC, Eastham CL, Harrison DG. Effect of Hypertension and Hypertrophy

on Coronary Microvascular Pressure. Circ Res 1992; 71:120-126. 61. Myers PR, Guerra R, Jr, Harrison DG. Release of Multiple Endothelium-Derived Relaxing Factors from Porcine

Coronary Arteries. J Cardiovasc Pharmacol 1992; 20:392-400. 62. Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, Murphy TJ.

Molecular Cloning and Characterization of the Constitutive Bovine Aortic Endothelial Cell Nitric Oxide Synthase. J Clin Invest 1992; 90:2092-2096.

63. Harrison DG, Kurz MA, Quillen JE, Sellke FW, Mügge A. Normal and Pathophysiologic Considerations of Endothelial

Regulation of Vascular Tone: Relevance to Nitrate Therapy. Am J Cardiol 1992;70:11B-17B. 64. Münzel T, Mulsch A, Holtz J, Just H, Harrison DG, Bassenge E. Mechanisms of Interaction Between the Sulfhydryl

Precursor L-Methionine and Glyceryl Trinitrate. Circulation 1992; 86:995-1003. 65. Harrison DG, Bates JN. The Nitrovasodilators: New Ideas About Old Drugs. Circulation 1993; 87:1461-1467. 66. Kurz MA, Boyer TD, Harrison DG. Nitroglycerin Metabolism in Vascular Tissue: Role of Glutathione-S-Transferases

and the Relationship Between NO· and NO2¯ Formation. Biochem J 1993; 292:545-550. 67. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia Increases Endothelial Superoxide Anion Production. J Clin

Invest 1993; 91:2546-2551. 68. Delafontaine P, Lou H, Harrison DG, Bernstein KE. Sequence of a cDNA Encoding Dog Insulin-Like Growth Factor I.

Gene 1993; 130:305-306. 69. Wheatley RM, Dockery SP, Kurz MA, Harrison DG. Interactions of Nitroglycerin and Sulfhydryl Donating Compounds

in Canine Coronary Microvessels. Am J Physiol 1994; 266:H291-297. 70. Lamping KG, Bloom EN, Harrison DG. Regulation of Native Collateral Vessel Dilation Following Coronary Occlusion

in the Dog. Am J Physiol 1994; 266:H769-778. 71. Ohara Y, Peterson TE, Zheng B, Kuo JF, Harrison DG. Lysophosphatidylcholine Increases Vascular Superoxide Anion

Production Via Protein Kinase C Activation. Arterioscler Thromb Vasc Biol 1994; 14:1007-1013. 72. Venema RC, Nishida K, Alexander RW, Harrison DG, Murphy TJ. Organization of the Bovine Gene Encoding the

Endothelial Nitric Oxide Synthase. Biochim Biophys Acta 1994; 1218:413-420. 73. Arnal J-F, Yamin J, Dockery SP, Harrison DG. Regulation of Endothelial Nitric Oxide Synthase mRNA, Protein and

Activity during Cell Growth. Am J Physiol 1994; 267:C1381-1388. 74. Münzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison, DG. Evidence for Enhanced Vascular Superoxide Anion

Production in Nitrate Tolerance: A Novel Mechanism Underlying Tolerance and Cross Tolerance. J Clin Invest 1995; 95:187-194.

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75. Harrison DG, Venema RC, Arnal J-F, Inoue Y, Ohara Y, Sayegh H, Murphy TJ. The Endothelial Cell Nitric Oxide Synthase: Is It Really Constitutively Expressed? Agents Actions Suppl 1995; 45:107-117.

76. Supari F, Ungerer T, Harrison DG, Williams JK. Fish Oil Treatment Decreases Superoxide Anions in the Myocardium

and Coronary Arteries of Atherosclerotic Monkeys. Circulation 1995; 91:1123-1128. 77. Ohara Y, Sayegh HS, Yamin JJ, Harrison DG. Regulation of Endothelial Constitutive Nitric Oxide Synthase by Protein

Kinase C. Hypertension 1995; 25:415-420. 78. Inoue N, Venema RC, Sayegh HS, Ohara Y, Murphy TJ, Harrison DG. Molecular Regulation of the Bovine Endothelial

Cell Nitric Oxide Synthase by Transforming Growth Factor beta-1. Arterioscler Thromb Vasc Biol 1995; 15:1255-1261. 79. Arnal J-F, Münzel T, Venema RC, James NL, Bay C-L, Mitch W, Harrison DG. Interactions Between L-arginine and L-

glutamine Modulate Endothelial NO Production: An Effect Independent of NO Synthase Substrate Availability. J Clin Invest 1995;95:2565-72.

80. Ohara Y, Peterson T, Sayegh SH, Harrison DG. Dietary Correction of Hypercholesterolemia in the Rabbit Normalizes

Endothelial Superoxide Anion Production. Circulation 1995; 92:898-903. 81. Münzel T, Giaid A, Kurz S, Stewart DJ, Harrison DG. Evidence for a Role of Endothelin-1 and Protein Kinase C in

Nitroglycerin Tolerance. Proc Natl Acad Sci USA 1995; 92:5244-5248. 82. Venema RC, Sayegh HS, Arnal J-F, Harrison DG. Role of the Enzyme Calmodulin-Binding Domain in Membrane

Association and Phospholipid Inhibition of Endothelial Nitric Oxide Synthase. J Biol Chem 1995; 270:14705-11411. 83. Uematsu M, Navas JP, Nishida Y, Ohara Y, Murphy TJ, Alexander RW, Nerem RM, Harrison DG. Regulation of

Endothelial Cell Nitric Oxide Synthase Expression by Shear Stress. Am J Physiol 1995; 269:C1371-1378. 84. James NL, Harrison DG, Nerem RM. Effects of Shear on Endothelial Cell Calcium in the Presence and Absence of ATP.

FASEB J 1995; 9:968-973. 85. Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM. Nitric Oxide Regulates VCAM-1 Gene Expression

and Redox-sensitive Transcriptional Events in Human Vascular Endothelial Cells. Proc Natl Acad Sci USA 1996; 93:9114-9119.

86. Venema RC, Sayegh HS, Kent, JD, Harrison DG. Identification, Characterization, and Comparison of the Calmodulin-binding Domains of the Endothelial and Inducible Nitric Oxide Synthases. J Biol Chem 1996; 271:6435-6440.

87. Rajagopalan S, Kurz S, Münzel T,Tarpey M, Freeman B, Griendling KK, Harrison DG. Angiotensin II Mediated Hypertension in the Rat Increases Vascular Superoxide Production via Membrane NADH/NADPH Oxidase Activation: Contribution to Alterations of Vasomotor Tone. J Clin Invest 1996; 97:1916-1923.

88. Münzel T, Heitzer T, Kurz S, Harrison DG, Luhman C, Pape L, Olschewski M, Just H. Dissociation of Coronary Vascular Tolerance and Neurohormonal Adjustments During Long-term Nitroglycerin Therapy in Patients with Stable Coronary Artery Disease. J Am Coll Cardiol 1996; 27:297-303.

89. Furukawa K, Harrison DG, Saleh D, Shennib H, Chagnon FP, Giaid A. Expression of Nitric Oxide Synthase in the Human Nasal Mucosa. Am J Respir Crit Care Med 1996;153:847-850.

90. Inoue N, Ramasamy S, Fukai T, Nerem R, Harrison DG. Shear Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human Aortic Endothelial Cells. Circ Res 1996; 79:32-37.

91. Wang S, Feelisch M, Harrison DG, Sellke F. Preferential Dilation of Large Coronary Microvessels by the Mononitrates SPM-4744 and SPM-5185. J Cardiovasc Pharmacol 1996; 27:587-593.

92. Münzel T, Kurz S, Rajagopalan S, Bennington W R, Thompson A, Freeman B, Harrison DG. Hydralazine Prevents Nitroglycerin Tolerance by Inhibiting Activation of a Membrane-bound NADH Oxidase: A New Action for an Old Drug. J Clin Invest 1996; 98:1465-1470.

93. Corson M, James N, Latta S, Nerem R, Berk B, Harrison DG. Phosphorylation of Endothelial Nitric Oxide Synthase in Response to Fluid Shear Stress. Circ Res 1996; 79:984-991.

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94. Rajagopalan S, Meng X-P, Ramasamy S, Harrison DG, Galis Z. Reactive Oxygen Species Produced by Macrophage-derived Foam Cells Regulate the Activity of Vascular Matrix Metalloproteinases in vitro: Implications for Atherosclerotic Plaque Stability. J Clin Invest 1996; 98:2572-2579.

95. Harrison DG. Cellular and Molecular Mechanisms of Endothelial Cell Dysfunction. J Clin Invest 1997; 100:2153-2157.

96. Fukui T, Rajagopalan S, Ishizaka N, Capers Q, Taylor WR, Harrison DG, de Leon H, Wilcox JN, Griendling KK. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res 1997; 80:45-51.

97. Bech Laursen J, Rajagopalan S, Tarpey M, Freeman B, Harrison DG. A Role of Superoxide in Angiotensin II - but not Catecholamine-induced Hypertension. Circulation 1997; 95:588-593.

98. Rajagopalan S, Bech Laursen J, Borthayre A, Kurz S, Keiser J, Haleen S, Giaid A, Harrison DG. A Role for Endothelin-1 in Angiotensin II-Mediated Hypertension. Hypertension 1997; 30:29-34.

99. Capers QT, Laursen JB, Fukui T, Rajagopalan S, Mori I, Lou P, Freeman BA, Berrington WR, Griendling KK, Harrison DG, Runge MS, Alexander RW, Taylor WR. Vascular Thrombin Receptor Regulation in Hypertensive Rats. Circ Res 1997; 80:838-844

100. Wilcox JN, Subramanian RR, Sundell CL, Tracey WR, Pollock JS, Harrison DG, Marsden PA. Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels. Arterioscler Thromb Vasc Biol 1997; 17:2479-2488.

101. Ramasamy S, Parthasarathy S, Harrison DG. Regulation of Endothelial Nitric Oxide Synthase Gene Expression by Oxidized Linoleic Acid. J Lipid Res 1998; 39:268-276.

102. Inoue N, Ohara Y, Fukai T. Harrison DG. Nishida K. Probucol Improves Endothelial-dependent Relaxation and

Decreases Vascular Superoxide Production in Cholesterol-fed Rabbits. Am J Med Sci 1998; 315:242-247. 103. Fukai T, Galis ZS, Meng XP, Parthasarathy S, Harrison, DG. Vascular Expression of Extracellular Superoxide Dismutase

in Atherosclerosis. J Clin Invest 1998; 101:2101-2111. 104. Vejlstrup NG, Bouloumie A, Boesgaard S, Anderson CB, Nielsen-Kudsk JE, Mortensen SA, Kent JD, Harrison DG,

Busse R, Aldershvile J. Inducible Nitric Oxide Synthase (iNOS) in the Human Heart: Expression and Localization in Congestive Heart Failure. J Mol Cell Cardiol 1998; 30:1215-1223.

105. Zafari AM, Ushio-Fukai M, Akers M, Yin Q, Shah A, Harrison DG, Taylor WR, Griendling KK. Role of NADH/NADPH

Oxidase-derived H2O2 in Angiotensin II-induced Vascular Hypertrophy. Hypertension 1998; 32:488-495. 106. Skatchkov MP, Sperling D, Hink U, Mulsch A, Harrison DG, Sindermann I, Meinertz T, Munzel T. Validation of

Lucigenin as a Chemiluminescent Probe to Monitor Vascular Superoxide as well as Basal Vascular Nitric Oxide Production. Biochem & Biophys Res Commun 1999; 254:319-324.

107. Huraux C, Makita T, Kurz S, Yamaguchi K, Szlam F, Tarpey MM, Wilcox JN, Harrison DG, Levy JH. Superoxide

Production, Risk Factors, and Endothelium-dependent Relaxations in Human Internal Mammary Arteries. Circulation 1999;99:53-9.

108. Fukai T, Siegfried M, Ushio-Fukai M, Griendling KK, Harrison DG. Modulation of Extracellular Superoxide Dismutase

Expression by Angiotensin II and Hypertension. Circ Res 1999; 85:23-28. 109. Ramasamy S, Drummond GR, Ahn J, Storek M, Pohl J, Parthasarathy S, Harrison DG. Modulation of Expression of

Endothelial Nitric Oxide Synthase by Antioxidants in Cultured Endothelial Cells. Mol Pharmacol 1999; 56:116-123. 110. Kurz S, Hink U, Nickenig G, Borthayre AB, Harrison DG, Munzel T. Evidence for a Causal Role of the Renin

Angiotensin System in Nitrate Tolerance. Circulation 1999; 99:3181-3187. 111. Kojda G, Laursen JB, Ramasamy S, Kent JD, Kurz S, Burchfield J, Shesely EG, Harrison DG. Protein Expression,

Vascular Reactivity and Soluble Guanylate Cyclase Activity in Mice Lacking the Endothelial Cell Nitric Oxide Synthase: Contributions of NOS Isoforms to Blood Pressure and Heart Rate Control. Cardiovasc Res 1999; 42:206-213.

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112. Warnholtz A, Nickenig G, Schulz E, Macharzina R, Brasen JH, Skatchkov M, Heitzer T, Stasch JP, Griendling KK, Harrison DG, Bohm M, Meinertz T, Munzel T. Increased NADH-oxidase-mediated Superoxide Production in the Early Stages of Atherosclerosis: Evidence for Involvement of the Renin-angiotensin System. Circulaiton 1999; 99:2027-2033.

113. Kojda G, Harrison DG. Interactions Between NO and Reactive Oxygen Species: Pathophysiological Importance in

Atherosclerosis, Hypertension, Diabetes and Heart Failure. Cardiovasc Res 1999; 43:562-571. 114. Tummala PE, Chen XL, Sundell CL, Laursen JB, Hammes CP, Alexander RW, Harrison DG, Medford RM. Angiotensin

II Induces Vascular Cell Adhesion Molecule-1 Expression in Rat Vasculature: A Potential Link between the Renin-Angiotensin System and Atherosclerosis. Circulation 1999; 100:1223-1229.

115. Munzel T. Hink U. Yigit H. Macharzina R. Harrison DG. Mulsch A. Role of Superoxide Dismutase in in vivo and in

vitro Nitrate Tolerance. Br J Pharmacol 1999; 127:1224-1230. 116. Gallis B, Corthals GL, Goodlett DR, Ueba H, Kim F, Presnell SR, Figeys D, Harrison DG, Berk BC, Aebersold R, and

Corson MA. Identification of Flow-dependent Endothelial Nitric Oxide Synthase Phosphorylation Sites by Mass Spectrometry and Regulation of Phosphorylation and Nitric Oxide Production by the Phosphatidylinositol 3-Kinase Inhibitor LY294002. J Biol Chem 1999; 274: 30101-30108.

117. Searles CD. Miwa Y, Harrison DG, Ramasamy S. Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase

during Cell Growth. Circ Res 1999; 85:588-595. 118. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and Posttranscriptional Regulation of

Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide. Circ Res 2000; 86:347-354. 119. Somers MJ, Mavromatis K, Galis ZS, Harrison DG. Vascular Superoxide Production and Vasomotor Function in

Hypertension Induced by Deoxycorticosterone Acetate-Salt. Circulation 2000; 101:1722-1728. 120. Fukai T, Siegfried M, Ushio-Fukai M, Cheng Y, Kojda G, Harrison DG. Regulation of Extracellular Superoxide

Dismutase by Nitric Oxide and Exercise Training. J Clin Invest 2000; 105:1631-1639. 121. Kleschyov AL. Mollnau H. Oelze M. Meinertz T. Huang Y. Harrison DG. Munzel T. Spin Trapping of Vascular Nitric

Oxide using Colloid Fe(II)-diethyldithiocarbamate. Biochem Biophys Res Commun 2000; 275:672-677.

122. Somers MJ, Burchfield JS, Harrison DG. Evidence for a NADH/NADPH Oxidase in Human Umbilical Vein Endothelial Cells using Electron Spin Resonance. Antioxid Redox Signal 2000; 2:779-787.

123. Bech Laursen J, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG.

Endothelial Regulation of Vasomotion in Apo(E)-deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin. Circulation 2001; 103:1282-1288.

124. Sorescu D, Somers MJ, Lassegue B, Grant S, Harrison DG, Griendling KK. Electron Spin Resonance Characterization of

the NAD(P)H Oxidase in Vascular Smooth Muscle Cells. Free Radic Biol & Med 2001; 30:603-612. 125. Kojda G, Cheng Y, Burchfield J, Harrison DG. Dysfunctional Regulation of eNOS Expression in Response to Exercise in

Mice Lacking One eNOS Gene. Circulation 2001; 103:2839-2844. 126. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RAK, Warnholtz A, Meinertz

T, Griendling KK, Harrison DG, Forstermann U, Munzel T. Mechanisms Underlying Endothelial Dysfunction in Diabetis Mellitus. Circ Res 2001; 88:14-22.

127. Uemura S, Matsushita H, Li W, Glassford AJ, Asagami T, Lee KH, Harrison DG, Tsao PS. Diabetes Mellitus Enhances

Vascular Matrix Metalloproteinase Activity: Role of Oxidative Stress. Circ Res 2001; 88:1291-1298. 128. Cai H, Davis ME, Drummond GR, Harrison DG. Induction of Endothelial Nitric Oxide Synthase by Hydrogen Peroxide

via a Ca2+/CaM Kinase II/JAK2-dependent Pathway. Arterioscler Thromb Vasc Biol 2001; 21:1571-1576.

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129. Davis ME, Cai H, Drummond GR, Harrison DG. Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression through c-Src by Divergent Signaling Pathways. Circ Res 2001; 89:1073-1080.

130. Fukai T, Folz RJ, Landmesser U, Harrison DG. Extracellular Superoxide Dismutase and Cardiovascular Disease.

Cardiovascular Res 2002; 55:239-249. 131. Dikalov S, Landmesser U, Harrison DG. Geldanamycin Leads to Superoxide Formation by Enzymatic and Non-

enzymatic Dedox Cycling: Implications for Studies of Hsp90 and eNOS. J Biol Chem 2002; 277:25480-25485. 132. Landmesser U, Cai H, Dikalov S, MccAnn L, Hwang J, Jo H, Holland SM, Harrison DG. Role of p47phox in Vascular

Oxidative Stress and Hypertension caused by Angiotensin II. Hypertension 2002; 40:511-515. 133. Cai H, Li Z, Dikalov S, Holland SM, Hwang J, Jo H, Dudley SC Jr, Harrison DG. NAD(P)H Oxidase-derived Hydrogen

Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II. J Biol Chem 2002; 277:48311-48317.

134. Nickenig G, Harrison DG. The AT(1) Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part I: Oxidative

Stress and Atherogenesis. Circulation 2002; 105:393-396. 135. Nickenig G, Harrison DG. The AT(1)-Type Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part II: AT(1)

Receptor Regulation. Circulation 2002; 105:530-536. 136. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T. Peroxidase

Properties of Extracellular Superoxide Dismutase: Role of Uric Acid in Modulating in vivo Activity. Arterioscler Thromb Vasc Biol 2002; 22:1402-1408.

137. Munzel T, Afanas’ev IB, Kleschyov AL, Harrison DG. Detection of Superoxide in Vascular Tissue. Arterioscler Thromb

Vasc Biol 2002; 11:1761-1768. 138. Cai H, Li Z, Goette A, Mera F, Honeycutt C, Feterik K, Wilcox JN, Dudley SC, Harrison DG, Langberg JJ.

Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation: Potential Mechanisms for Atrial Thrombosis and Stroke. Circulation 2002; 106:2854-2858.

139. Braddon LG, Karoyli D, Harrison DG, Nerem RM. Maintenance of a Functional Endothelial Cell Monolayer on a

Fibroblast/Polymer Substrate under Physiologically Relevant Shear Stress Conditions. Tissue Eng 2002; 8:695-708. 140. Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H. Vascular

Oxidative Stress and Endothelial Dysfunction in Patients with Chronic Heart Failure: Role of Xanthine-Oxidase and Extracellular Superoxide Dismutase. Circulation 2002; 106:3073-3078.

141. Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Sudley SC Jr. Akt-dependent Phosphorylation of Serine 1179 and

Mitogen-activated Protein Kinase Kinase/Extracellular Signal-regulated Kinase 1/2 Cooperatively Mediate Activation of the Endothelial Nitric Oxide Synthase by Hydrogen Peroxide. Mol Pharmacol 2003; 63:325-331.

142. Davis ME, Cai H, McCann L, Fukai T, Harrison DG. Role of c-Src in Regulation of Endothelial Nitric Oxide Synthase

Expression During Exercise Training. Am J Physiol Heart Circ Physiol 2003; 284:H1449-1453. 143. Spiekermann S, Landmesser U, Dikalov S, Bredt M, Gamez G, Tatge H, Reepschlager N, Hornig B, Drexler H, Harrison

DG. Electron Spin Resonance Characterization of Vascular Xanthine and NAD(P)H Oxidase Activity in Patients with Coronary Artery Disease: Relation to Endothelin-dependent Vasodilation. Circulation 2003;107:1383-1389.

144. Landmesser U, Dikalov S, Price R, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG. Oxidation of

Tetrahydrobiopterin Leads to Uncoupling of Endothelial Cell Nitric Oxide Synthase in Hypertension: Role of the NADPH Oxidase. J Clin Invest 2003; 111:1201-1209.

145. Harrison DG, Cai H, Landmesser U, Griendling KK. Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress

and cardiovascular disease. J Renin Angiotensin Aldosterone Syst 2003;4:51-61.

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146. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid

and Thiols: Implications for Uncoupling Endothelial Nitric Oxide Synthase. J Biol Chem 2003; 278:22546-22554. 147. Boo YC, Sorescu GP, Bauer PM, Fulton D, Kemp BE, Harrison DG, Sessa WC, Jo H. Endothelial NO Synthase

Phosphorylated at Ser635 Produces NO Without Requiring Intracellular Calcium Increase. Free Radic Biol Med 2003;35:729-41.

148. Hwang J, Saha A, Boo YC, Sorescu GP, McNally JS, Holland SM, Dikalov S, Giddens DP, Griendling KK, Harrison DG,

Jo H. Oscillatory Shear Stress Stimulates Endothelial Production of O2•- from p47phox-dependent NAD(P)H Oxidases Leading to Monocyte Adhesion. J Biol Chem 2003; 278:47291-47298.

149. McNally JS, Davis ME, Giddens DP, Saha A, Hwang J, Dikalov S, Jo H, Harrison DG. Role of Xanthine Oxidoreductase

and the NAD(P)H Oxidase in Endothelial Superoxide Production in Response to Oscillatory Shear Stress. Am J Physiol Heart Circ Physiol 2003; 285:H2290-2297.

150. Cai H, Griendling KK, Harrison DG. The Vascular NAD(P)H Oxidases as Therapeutic Targets in Cardiovascular

Diseases. Trends Pharmacol Sci 2003; 24:471-478. 151. Khatri JJ, Johnson C, Magid R, Lessner S, Laude K, Dikalov S, Harrison DG, Galis ZS. Vascular Oxidant Stress

Enhances Progression and Angiogenesis of Experimental Atheroma. Circulation 2004;109:520-5. 152. Davis ME, Grumbach IM, Fukai T, Cutchins A, Harrison DG. Shear Stress Regulates Endothelial Nitric Oxide Synthase

Promoter Activity through Nuclear Factor Kappa-B Binding. J Biol Chem 2004; 279:163-8. 153. Wyche KE, Wang SS, Griendling KK, Dikalov SI, Austin H, Rao S, Fink B, Harrison DG, Zafari AM. C242T CYBA

Polymorphism of the NADPH Oxidase is Associated with Reduced Respiratory Burst in Human Neutrophils. Hypertension 2004; 43:1246-1251.

154. Ridker PM, Brown NJ, Vaughan DE, Harrison DG, Mehta JL. Established and Emerging Plasma Biomarkers in the

Prediction of First Atherothrombotic Events. Circulation 2004; 109:6-19. 155. Cai H, McNally JS, Weber M, Harrison DG. Oscillatory Shear Stress Upregulation of Endothelial Nitric Oxide Synthase

Requires Intracellular Hydrogen Peroxide and CaMKII. J Mol Cell Cardiol 2004; 37:121-125. 156. Fink B, Laude K, McCann L, Doughan A, Harrison DG, Dikalov S. Detection of Intracellular Superoxide Formation in

Endothelial Cells and Intact Tissues Using Dihydroethidium and an HPLC-based Assay. Am J Physiol Cell Physiol 2004; 287:C895-902.

157. Weber DS, Rocic P, Mellis AM, Laude K, Lyle AN, Harrison DG, Griendling KK. Angiotensin II-induced Hypertrophy

is Potentiated in Mice Overexpressing p22phox in Vascular Smooth Muscle. Am J Physiol Heart Circ Physiol 2005; 288:H37-42.

158. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy R,

Gamez G, Griendling KK, Harrison DG. Hemodynamic and Biochemical Adaptations to Vascular Smooth Muscle Overexpression of p22phox in Mice. Am J Physiol Heart Circ Physiol 2005; 288:H7-H12.

159. Abramson JL, Hooper WC, Jones DP, Ashfaq CS, Rhodes SD, Weintraub WS, Harrison DG, Quyyumi AA, Vaccarino V.

Association Between Novel Oxidative Stress Markers and C-reactive Protein Among Adults Without Clinical Coronary Heart Disease. Atherosclerosis 2005; 178:115-21.

160. Lauer N, Suvorava T, Ruther U, Jacob R, Meyer W, Harrison DG, Kojda G. Critical Involvement of Hydrogen Peroxide

in Exercise-Induced Upregulation of Endothelial NO Synthase. Cardiovasc Res 2005; 65:254-262. 161. Jeney V, Itoh S, Wendt M, Gradek Q, Ushio-Fukai M, Harrison DG, Fukai T. Role of Antioxidant-1 in Extracellular

Superoxide Dismutase Function and Expression. Circ Res, 2005; 96:723-729.

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162. Weber M, Hagedorn CH, Harrison DG, Searles CD. Laminar Shear Stress and 3’ Polyadenylation of eNOS mRNA. Circ Res, 2005; 96:1161-8.

163. McNally JS, Saxena A, Cai H, Dikalov S, Harrison DG. Regulation of Xanthine Oxidoreductase Protein Expression by

Hydrogen Peroxide and Calcium. Arterioscler Thromb Vasc Biol, 2005;25:1623-8. 164. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of Peroxynitrite with Uric Acid in the Presence of

Ascorbate and Thiols: Implications for Uncoupling Endothelial Nitric Oxide Synthase. Biochem Pharmacol, 2005; 70:343-54.

165. Grumbach IM, Chen W, Mertens SA, Harrison DG. A Negative Feedback Mechanism Involving Nitric Oxide and

Nuclear Factor Kappa-B Modulates Endothelial Nitric Oxide Synthase Transcription. J Mol Cell Cardiol, 2005; 39:595-603.

166. Dudley SC, Hoch NE, McCann LA, Honeycutt C, Diamandopoulos L, Fukai T, Harrison DG, Dikalov SI, Langberg J.

Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage: Role of the NADPH and Xanthine Oxidases. Circulation, 2005; 112:1266-1273.

167. Mueller CFH, Widder JD, McNally JS, McCann L, Jones DP, Harrison DG. The Role of the Multidrug Resistance

Protein-1 in Modulation of Endothelial Cell Oxidative Stress. Circ Res 2005; 97:637-644. 168. Modlinger P, Chabrashvili T, Gill PS, Mendonca M, Harrison DG, Griendling KK, Li M, Raggio J, Wellstein A, Chen Y,

Welch WJ, Wilcox CS. RNA Silencing In Vivo Reveals Role of p22phox in Rat Angiotensin Slow Pressor Response. Hypertension, 2006; 47:238-244.

169. Guzik TJ, Sadowski J, Guzik B, Jopek A, Kapelak B, Przybylowski P, Wierzbicki K, Harrison DG, Rorbut R, Channon

KA. Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease. Arterioscler Thromb Vasc Biol, 2005;26:333-339.

170. Ashfaq S, Abramson JL, Jones DP, Rhodes SD, Weintraub WS, Hooper WC, Vaccarino V, Harrison DG, Quyyumi AA.

The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults. J Am Coll Cardiol, 2006; 47:1005-1011.

171. Miriyala S, Gongora Nieto MC, Mingone C, Smith D, Dikalov S, Harrison DG, Jo H. Bone Morphogenic Protein-4

Induces Hypertension in Mice. Role of Noggin, Vascular NADPH Oxidases, and Impaired Vasorelaxation. Circulation, 2006;113:2818-2825.

172. Gongora MC, Qin Z, Laude K, Kim HW, McCann L, Folz JR, Dikalov S, Fukai T, Harrison DG. Role of Extracellular

Superoxide Dismutase in Hypertension. Hypertension, 2006; 48:473-481. 173. Boulden BM, Widder JD, Allen JC, Smith DA, Al-Baldawi RN, Harrison DG, Dikalov SI, Jo H, Dudley SC Jr.. Early

Determinants of H202-induced Endothelial Dysfunction. Free Radic Biol Med, 2006;41:810-817.

174. Ramchandran R, Takezako T, Saad Y, Stull L, Fink B, Yamada H, Dikalov S, Harrison DG, Moravec C, Karnik SS. Angiotensinergic Stimulation of Vascular Endothelium in Mice Causes Hypotension, Bradycardia, and Attenuated Angiotensin Response. Proc Natl Acad Sci USA, 2006; 103:19087-19092.

175. Widder JD, Guzik TJ, Mueller CF, Clempus RE, Schmidt HH, Dikalov SI, Griendling KK, Jones DP, Harrison DG. Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arterioscler Thromb Vasc Biol. 2007; 27:762-768.

176. San Martin A, Du P, Dikalova A, Lassegue B, Aleman M, Gongora MC, Brown K, Joseph G, Harrison DG, Taylor WR,

Jo H, Griendling KK. Reactive Oxygen Species-selective Regulation of Aortic Inflammatory Gene Expression in Type 2 Diabetes. Am J Physiol Heart Circ Physiol, 2007; 292:H2073-2082.

177. Widder JD, Chen W, Li L, Dikalov S, Thöny B, Hatakeyama K, Harrison DG. Regulation of Tetrahydrobiopterin

Biosynthesis by Shear Stress. Circ Res. 2007;101:830-838.

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178. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG. Role of the T-Cell in the Genesis of Angiotensin II-Induced Hypertension and Vascular Dysfunction. J Exp Med, 2007; 204:2449-2460.

179. Dikalov S, Griendling KK, Harrison DG. Measurement of reactive oxygen species in cardiovascular studies.

Hypertension. 2007; 49:717-727. 180. Doughan, AK, Harrison DG, Diklov SI. Molecular Mechanisms of Angiotensin II-Mediated Mitochondrial Dysfunction:

linking mitochondrial oxidative damage and vascular endothelial dysfunction. Cir Res, 2007; 102:488-496 181. Cai H, Dikalov S, Griendling KK, Harrison DG. Detection of reactive oxygen species and nitric oxide in vascular cells

and tissues: comparison of sensitivity and specificity. Methods Mol Med. 2007;139:293-312. 182. Chen W, Bacanamwo M, Harrison DG. Activation of p300 histone acetyl-transferase activity is an early endothelial

response to laminar shear stress and is essential for stimulation of eNOS mRNA transcription. J Biol Chem. 2008; 283:16293-16298.

183. S, Abramson JL, Jones DP, Rhodes SD, Weintraub WS, Hooper WC, Vaccarino V, Alexander RW, Harrison DG,

Quyyumi AA. Endothelial Function and Aminothiol Biomarkers of Oxidative Stress in Healthy Adults. Hypertension, 2008; 52:80-85

184. Porkert M, Sher S, Reddy U, Cheema F, Niessner C, Kolm P, Jones DP, Hooper C, Taylor WR, Harrison DG, Quyyumi

AA. Tetrahydrobiopterin: a novel antihypertensive therapy. J Hum Hypertens. 2008; 22:401-407. 185. Gongora MC, Lob HE, Landmesser U, Guzik TJ, Martin WD, Ozumi K, Wall SM, Wilson DS, Murthy N, Gravanis M,

Fukai T, Harrison DG. Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome. Am J Pathol. 2008; 173:915-926.

186. Qin Z, Gongora MC, Ozumi K, Itoh S, Akram K, Ushio-Fukai M, Harrison DG, Fukai T. Role of Menkes ATPase in

Angiotensin II-Induced Hypertension. A key modulator for extracellular superoxide dismutase function. Hypertension. 2008; 52:945-951.

187. Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Mangalat D, Hoch N, Dikalov S, Rudzinski P, Kapelak B, Sadowski

J, Harrison DG. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. J Am Coll Cardiol. 2008; 52:1803-1809.

188. Hoch NE, Guzik TJ, Chen W, Deans T, Maalouf SA, Gratze P, Weyand C, Harrison DG. Regulation of T cell function by

endogenously produced angiotensin II. Am J Physiol Regul Integr Comp Physiol. 2008; 296:R208-216. 189. Jones R, Baker MB, Weber M, Harrison DG, Bao G, Searles CD. Molecular Beacons Can Assess Changes in Expression

and 3' Polyadenylation of Human eNOS mRNA. Am J Physiol Cell Physiol. 2009; 296:C498-504. 190. Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, Boyadjian R, Bikineyeva A, Praticò D, Harrison DG, Hsueh

WA. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res. 2009; 104:e42-54. 191. Shuvaev VV, Chistofidou-Solomidou M, Bhora F, Laude K, Cai H, Dikalov S, Arguiri E, Solomides CC, Albelda SM,

Harrison DG, Muzykantiv VR. Targeted detoxification of selected reactive oxygen species in the vascular endothelium. J Pharm Exp Ther. 2009; 331:404-411.

192. Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison DG, Giddens D, Jo H. Partial carotid ligation is a model

of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. Am J Physiol Heart Circ Physiol. 2009; 297:H1535-1543.

193. Silberman GA, Fan TH, Liu H, Jiao Z, Xiao HD, Lovelock JD, Boulden BM, Widder J, Fredd S, Bernstein KE, Wolska

BM, Dikalov S, Harrison DG, Dudley SC Jr. Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation. 2010; 121:519-528.

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194. Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, Guzik TJ, Harrison DG. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension. 2010; 55:500-507.

195. Lob HE, Marvar PJ, Guzik TJ, Sharma S, McCann LA, Weyand C, Gordon FJ, Harrison DG. Induction of hypertension

and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension. 2010; 55:277-283.

196. Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H, Harrison DG, Chen W. GTP cyclohydrolase i phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Circ Res. 2010; 106:328-336.

197. Bonsall JM, Hughes R, Mosunjac M, Harrison DG, Samady H. A rare case of squamous cell carcinoma of the bladder presenting as a metastatic right ventricular mass. Case Reports in Med. 2010; ePUB

198. Kalogeropoulos A, Georgiopoulou V, Psaty BM, Rodondi N, Smith AL, Harrison DG, Liu Y, Hoffmann U, Bauer DC, Newman AB, Kritchevsky SB, Harris TB, Butler J, Health ABC Study Investigators; Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J Am Coll Cardiol. 2010; 55:2129-2137.

199. Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG, Dikalov SI. Therapeutic Targeting of Mitochondrial Superoxide in Hypertension. Circ Res. 2010, 107:106-116

200. Schneider MP, Sullivan JC, Wach PF, Boesen EI, Yamamoto T, Fukai T, Harrison DG, Pollock DM, Pollock JS.

Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury. Kidney Int., 2010, 78:374-378 201. Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, Gordon FJ, Harrison DG. Central and Peripheral

Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II-Induced Hypertension. Circ Res. 2010, 107:263-270

202. Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison DG, Giddens DP, Jo H. A model of disturbed flow-

induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of RNA isolation from carotid endothelium. J Vis Exp. 2010, pii: 1861

203. Dikalova AE, Gongora MC, Harrison DG, Lambeth JD, Dikalov S, Griendling KK. Upregulaiton of Nox1 in vascular

smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol. 2010, 299:H673-679.

204. VinhA,ChenW,BlinderY,WeissD,TaylorWR,GoronzyJJ,WeyandCM,HarrisonDG,GuzikTJ.Inhibitionand

geneticablationoftheB7/CD28T‐cellcostimulationaxispreventsexperimentalhypertension.Circulation.2010;122:2529‐2537.

205. ChenW,LiL,BrodT,SaeedO,ThabetS,JansenT,DikalovS,WeyandC,GoronzyJ,HarrisonDG.Theroleof

increasedguanosinetriphosphatecyclohydrolase‐1expressionandtetrahydrobiopterinlevelsuponTcellactivation.JBiolChem.2011,286:13846‐13851.

206. McDanielMC,GalbraithEM,JeroudiAM,KashlanOR,EshtehardiP,SuoJ,DhawanS,VoeltzM,DevireddyC,Oshinski

J,HarrisonDG,GiddensDP,SamadyH.LocalizationofculpritlesionsincoronaryarteriesofpatientswithST‐segmentelevationmyocardialinfarctions:Relationtobifurcationsandcurvatures..AmHeartJ.2011,161:508‐515.

207. MadhurMS,FuntSA,LiL,VinhA,ChenW,LobHE,IwakuraY,BlinderY,RahmanA,QuyyumiAA,HarrisonDG..

RoleofInterleukin17inInflammation,Atherosclerosis,andVascularFunctioninApolipoproteinE‐DeficientMice.ArteriosclerThrombVascBiol.2011.31:1565‐1572.

208. LiL,ChenW,RezvanA,JoH,HarrisonDG.TetrahydrobiopterinDeficiencyandNitricOxideSynthase.Uncoupling

ContributetoAtherosclerosisInducedbyDisturbedFlow.ArteriosclerThrombVascBiol.2011.31:1547‐1554.209. LiL,DuY,ChenW,FuH,HarrisonDG.ANovelHigh‐ThroughputScreeningAssayforDiscoveryofMoleculesThat

IncreaseCellularTetrahydrobiopterin.JournalofBiomolecularScreening.2011.16:836‐844.

20

210. LobHE,VinhA,LiL,BlinderY,OffermannsS,HarrisonDG.Roleofthevascularextracellularsuperoxidedismutaseinhypertension.Hypertension.2011.58:232‐239.

211. ErezA,SandeshNagamaniSCS,ShchelochkovOA,PremkumarMH,CampeauPM,ChenY,GargHK,LiL,MianA,

BertinTK,BlackJO,ZengH,TangY,ReddyAK,MarshallSummarM,O’BrienWE,HarrisonDG,MitchWE,MariniJC,AschnerJL,BryanNS,andLeeB.RequirementofArgininosuccinateLyaseforSystemicNitricOxideProduction.NatureMedicine,2011.17:1619‐626.

212. MarvarPJ,VinhA,ThabetS,LobHE,GeemD,ResslerKJ,HarrisonDG.TLymphocytesandVascularInflammationContributetoStress‐DependentHypertension.BiologicalPsychiatry,2012.71:774‐782.

213. YounJY,WangT,BlairJ,LaudeKM,OakJH,McCannLA,HarrisonDG,CaiHL.Endothelium‐specificSepiapterinReductaseDeficiencyinDOCA‐saltHypertension.AmJPhysiolHeartCircPhysiol.2012:H2243‐2249.

214. FelgerJC,LiL,MarvarPJ,WoolwineBJ,HarrisonDG,RaisonCL,MillerAH.Tyrosinemetabolismduringinterferon‐alphaadministration:AssociationwithfatigueandCSFdopamineconcentrations.BrainBehavImmun.2012,Inpress.

215. LobHE,SchultzD,Marvar,PM,DavissonRL,HarrisonDG.RoleoftheNADPHOxidasesintheSubfornicalOrganinAngiotensinII‐InducedHypertension.Hypertension,2013, 61:382-387.

216. Pech V, Thumova M, Dikalov SI, Hummler E, Rossier BC, Harrison DG, Wall SM. Nitric Oxide reduces Cl- absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism. Am J Physiol Renal Physiol. 2013, In Press

217. ChowK,FesselJP,KaoriihidaS,SchmidtEP,GaskillC,AlvarezD,GrahamB,HarrisonDG,WagnerDH,Jr.,Nozik‐GrayckE,WestJD,KlemmDJ,MajkaSM.Dysfunctionalresidentlungmesenchymalstemcellscontributetopulmonarymicrovascularremodeling.PulmCirc.2013;3:31‐49.

218. WiigH,SchroderA,NeuhoferW,JantschJ,KoppC,KarlsenTV,BoschmannM,GossJ,BryM,RakovaN,DahlmannA,BrennerS,TenstadO,NurmiH,MervaalaE,WagnerH,BeckFX,MullerDN,KerjaschkiD,LuftFC,HarrisonDG,AlitaloK,TitzeJ.Immunecellscontrolskinlymphaticelectrolytehomeostasisandbloodpressure.JClinInvest.2013,123:2803-15

219. FengQ,VickersKC,AndersonMP,LevinMG,ChenW,HarrisonDG,WilkeRA.AcommonfunctionalpromotervariantlinksCNR1geneexpressiontoHDLcholesterollevel.NatCommun.2013;4:1973.

220. Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassegue B, Griendling KK, Harrison DG, Dikalova AE. Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension. Antioxid Redox Signal. 2014;20:281-294.

221. Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, and Harrison DG. Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of p38 Mitogen-Activated Protein Kinase. Circ Res 114: 616-625, 2014.

222. Youn JY, Siu KL, Lob H, Itani H, Harrison DG, and Cai H. Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome. Diabetes 2014.

223. TrottDW,ThabetSR,KiraboA,SalehM,ItaniH,NorlanderAE,WuJ,GoldsteinA,ArendshorstWJ,LiCL,ShyrY,ChenW,MadhurMS,HarrisonDG.OligoclonalCD8+Tcellsplayacriticalroleinthedevelopmentofhypertension.Hypertension.2014;InPress

224. KiraboA,FontanaV,deFariaAPC,LoperenaR,GalindoCL,WuJ,BikineyevaAT,DikalovS,XiaoL,ChenW,SalehMA,D.W.T,ItaniHA,VinhA,AmarnathV,AmarnathK,GuzikTJ,Bernstein.KE,ShenXZ,ShyrY,ChenSC,MernaughRL,LafferCL,ElijovichF,DaviesSL,MorenoLH,MadhurMS,RobertsIIJ,HarrisonDG.Dendriticcellisoketal‐modifiedproteinsactivateTcellsandpromotehypertension.JournalofClinicalInvestigation.2014;Inpress

21

B. Reviews,CaseReports,Letters,Editorials

1. WhiteCW,HiratzkaLF,EasthamCL,HarrisonDG,MarcusML:ArteriogramandthePhysiologicalSignificanceofCoronaryStenoses.CardiologyBoardRev1984;1:118‐123

2. MarcusML,HarrisonDG,WhiteCW,HiratzkaLF:AssessingthePhysiologicalSignificanceofCoronaryObstructioninMan.CanJCardiol1986;195A‐199A

3. MarcusML,HiratzkaLF,DotyDB,WrightCB,HarrisonDG,WhiteCW:CoronaryObstructiveLesions:AssessingTheirPhysiologicalSignificanceinHumans.AnnThoracSurg1986;42:S5‐S8

4. MarcusML,HiratzkaLF,WhiteCW,HarrisonDG,EasthamCL,KerberRE:ApplicationofDopplerTechnologytoStudiesoftheCoronaryCirculation.CardiovascClin1986;17:33‐43

5. HeistadDD,HarrisonDG,ArmstrongML:SerotoninandExperimentalVascularDisease.IntJCardiol1987;14:205‐212

6. MarcusML,SkortonDJ,JohnsonMR,CollinsSM,HarrisonDG,KerberRE:VisualEstimatesofPercentDiameterCoronaryStenosis:“ABatteredGoldStandard.”JAmCollCardiol1988;11:882‐885

7. MarcusML,HarrisonDG,WhiteCW,McPhersonDD,WilsonRF,KerberRE:AssessingthePhysiologicSignificanceofCoronaryObstructionsinPatients:ImportanceofDiffuseUndetectedAtherosclerosis.ProgCardiovascDis1988;31:39‐56

8. HarrisonDG:FromIsolatedVesselstotheCatheterizationLaboratory.StudiesofEndothelialFunctionintheCoronaryCirculationofHumans.Circulation1989;80:703‐706.

9. HarrisonDG,SellkeFW,QuillenJE:NeurohumoralRegulationofCoronaryCollateralVasomotorTone.BasicResinCardiol1990;85:121‐12

10. ArmstrongML,HeistadDD,MeganMB,LopezJA,HarrisonDG:ReversibilityofAtherosclerosis.CardiovascClin1990;20:113‐126

11. HarrisonDG:EndothelialModulationofVascularTone:RelevancetoCoronaryAngioplastyandRestenosis.JAmCollCardiol1991;17:71B‐76B

12. HarrisonDG,TreasureCB,MüggeA,DellspergerKC,LampingKG:HypertensionandtheCoronaryCirculation:WithSpecialAttentiontoEndothelialRegulation.AmJHypertension1991;4:454S‐459S

13. HarrisonDG:TheEndothelialCell.HeartDiseaseandStroke1992;2:95‐9914. HarrisonDG:EndothelialDysfunctioninAtherosclerosis.BasicResCardiol1993;88:87‐10215. NeremRM,HarrisonDG,TaylorWR,AlexanderRW:Hemodynamicsandvascularendothelialbiology.Journalof

CardiovascularPharmacology.1993;21:Suppl1:S6‐10.16. HarrisonDG:EndothelialDysfunctionintheCoronaryMicrocirculation:ANewClinicalEntityoranExperimental

Finding?JClinInvest1993;1:1‐217. HarrisonDG:EndogeneundTherapeutischeNitrateinGesundenundArterioskleroischenGefässen.Schweiz.

RundschauMedPrax1993;82:1172‐117618. HarrisonDG:EndothelialRegulationofVasomotion:AlterationsinAtherosclerosis.CanJCardiol1993;9:1A‐6A19. HarrisonDG:PhysiologicalAspectsofVascularEndothelialCellInteractionsinHypertensionand

Atherosclerosis.ActaAnaesthesiolScand1993;37:10‐1520. HarrisonDG,MünzelT:Nitroglycerin:WhatCausesNitroglycerinTolerance?PrimaryCardiology1994;20:30‐4721. ArnalJ‐F,MichelJ‐B,HarrisonDG:NitricOxideinthePathogenesisofHypertension.CurrOpinNephroland

Hypertens1995;4:182‐18822. HarrisonDG:EndothelialDysfunctioninAtherosclerosis.BasicResCardiol1994;1:87‐10223. HarrisonDG:AlterationsofVasomotorRegulationinAtherosclerosis.CardiovascularDrugsandTherapy1994;

9:55‐63

22

24. HarrisonDG,OharaY.Physiologicconsequencesofincreasedvascularoxidantstressesinhypercholesterolemiaandatherosclerosis:implicationsforimpairedvasomotion.AmJCardiol1995;75:75B‐81B

25. HarrisonDG.EndothelialControlofVasomotionandNitricOxideProduction:APotentialTargetforRiskFactorManagement.CardiolClin1996;14:1‐15

26. Rajagopalan,S,HarrisonDG.ReversingEndothelialDysfunctionwithACEInhibitors:AnewTREND?Circulation1996;94:240‐243

27. MünzelT,KurzS,HeitzerT,HarrisonDG.Newinsightsintomechanismsunderlyingnitratetolerance.AmJCardiol1996;77:24C‐30C.

28. HarrisonDG,SayeghHypertension,OharaY,InoueN,VenemaRC.RegulationofExpressionoftheEndothelialCellNitricOxideSynthase.ClinExpPharmacolPhysiol1996;23:251‐255.

29. BechLaursenJ,HarrisonDG.ModulationofMyocardialOxygenConsumptionthroughACEInhibitors:NOEffect?Circulation1997;95:14‐6.

30. KurzS,HarrisonDG.InsulinandtheArginineParadox.JClinInvest1997;99:369‐370.31. HarrisonDG.EndothelialFunctionandOxidantStress.ClinCardiol1997;20:1‐17.32. MunzelT,HarrisonDG.EvidenceforaRoleofOxygen‐derivedRadicalsandProteinKinaseCinNitrate

Tolerance.JMolMed1997;75:891‐900.33. HarrisonDG.EndothelialFunctionandOxidantStress.ClinCardiol1997;20:11‐17.34. DrummondGR,HarrisonDG.eNOS‐overexpressingMice:TooMuchNOMakestheBloodPressureLow.JClin

Invest1998;102:2033‐4.35. HarrisonDG.OxidativeStressandCoronaryArteryDisease.CanadianJournalofCardiology1998;14Suppl

D:30D‐32D.36. HarrisonDG,GalisZ,ParthasarathyS,GriendlingKK.OxidativeStressandHypertension.HypertensionPrimer,

Baltimore:Lippincott,Williams&Wilkins,1999,pp163‐166.37. GriendlingKK,HarrisonDG.DualRoleofReactiveOxygenSpeciesinVascularGrowth.CircRes1999;85:562‐

563.38. MunzelT,HarrisonDG.IncreasedSuperoxideinHeartFailure:ABiochemicalBaroreflexGoneAwry.Circulation

1999;100:216‐218.39. SearlesCD.HarrisonDG.Theinteractionofnitricoxide,bradykinin,andtheangiotensinIItype2receptor:

lessonslearnedfromtransgenicmice.JClinInvest1999;104:1013‐1014.40. SomersMJ,HarrisonDG.ReactiveOxygenSpeciesandtheControlofVasomotorTone.CurrHypertensRep1999;

1:102‐110.41. ShahAM,VallanceP,HarrisonDG.NOinthecardiovascularsystem.CardiovascRes1999;43:507‐508.42. LauerN.HarrisonDG.KojdaG.Nitricoxide(NO)andvascularoxidativestress.Newpathologicmechanismsand

bloodvesseldiseases.[German]MedMonatsschrPharm1999;22:382‐387.43. SchultzD,HarrisonDG.QuestforFire:SeekingtheSourceofPathogenicOxygenRadicalsinAtherosclerosis.

ArteriosclerThrombVascBiol2000;20:1412‐1413.44. WeintraubWS,HarrisonDG.C‐reactiveprotein,inflammationandatherosclerosis:dowereallyunderstandit

yet?EuropeanHeartJournal2000;21:958‐960.45. CaiH,HarrisonDG.EndothelialDysfunctioninCardiovascularDiseases:TheRoleofOxidantStress.Circulation

2000;87:840‐844.46. WeberM,HarrisonDG.KojdaG.Nitricoxide(NO)andvascularoxidativestress.Importanceincoronarydisease,

hypertension,diabetesmellitusandheartfailure.[German]MedMonatsschrPharm2000;23:12‐17.47. GriendlingKK,HarrisonDG.Out,DamnedDot:StudiesoftheNADPHOxidaseinAtherosclerosis.JClinInvest

2001;108:1423‐1424(editorial).

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48. DavisMandHarrisonDG.CrackingDownonCaveolin:ARoleofHMGCoAReductaseInhibitorsinModulatingEndothelialCellNitricOxideProduction.Circulation2001;103:2‐4.

49. LandmesserUandHarrisonDG.Oxidativestressandvasculardamageinhypertension.CoronaryArteryDisease2001;12:455‐461.

50. LandmesserU,HarrisonDG.Oxidantstressasamarkerforcardiovascularevents:Oxmarksthespot.Circulation2001;104:2638‐40.

51. ZafariAM,HarrisonDG.FreeRadicalsinHeartFailure:TherapeuticTargetsforOldandNewDrugs.CongestHeartFail2002;8:129‐30.

52. FukaiT,FolzRJ,LandmesserU,HarrisonDG.ExtracellularSuperoxideDismutaseandCardiovascularDisease.CardiovascularRes2002;239‐249.

53. HarrisonDG,CaiH.EndothelialControlofVasomotionandNitricOxideProduction.CardiolClin2003;21:289‐302.

54. SonSM,WhalinMK,HarrisonDG,TaylorWR,GriendlingKK.OxidativeStressandDiabeticVascularComplications.CurrDiabRep2004;4:247‐52.

55. MuellerCF,LaudeK,McNallyJS,HarrisonDG.RedoxMechanismsinBloodVessels.ArteriosclerThrombVascBiol2005;25:274‐278.

56. WidderJD,HarrisonDG.CanvitaminEpreventcardiovasculareventsandcancer?NatClinPractCardiovascMed.2005;10:510‐1.

57. HarrisonDG.Theshearstressofkeepingarteriesclear.NatMed.2005;4:375‐6.58. LandmesserJ,HarrisonDG,DrexlerH.OxidantStress–AMajorCauseofReducedEndothelialNitricOxide

AvailabilityinCardiovascularDisease.EurJClinPharmacol2006;13‐9.59. Harrison,DG,WidderJ.GrumbachI,ChenW,WeberM,SearlesC.Endothelialmechanotransduction,nitricoxide

andvascularinflammation.JInternMed2006;259:351‐63.60. GuzikTG,Harrison,DG.VascularNADPHoxidasesasdrugtargetsfornovelantioxidantstrategies.DrugDiscov

Today2006;11:524‐33.61. GuzikTG,Harrison,DG.EndothelialNF‐kBasamediatorofkidneydamage:Themissinglinkbetweensystemic

vascularandrenaldisease.CircRes2007;101:227‐9.62. GuzikTJ,Harrison,DG.EndothelialNF‐kappaBasamediatorofkidneydamage:themissinglinkbetween

systemicvascularandrenaldisease?CircRes.2007;101:268‐76.63. GongoraMC,Harrison,DG.SadheartfromnoSOD.Hypertension.2008;51:19‐25.64. Harrison,DG,BrownWV,RaggiP.EnhancedHype.AmericanJournalofCardiology.2008;102:368‐9.65. DaiberA,HarrisonDG,MunzelT.Doubtaboutanessentialroleforconstitutivenitricoxidesynthasein

nitroglycerin‐mediatedvasodilation.ProcNatlAcadSciUSA.2008,105:E92;authorreplyE93.66. HarrisonDG,GuzikTJ,GoronzyJ,WeyandC.Ishypertensionanimmunologicdisease?CurrCardiolRep.2008,

10:464‐469.67. MarvarPJ,GordonFJ,HarrisonDG.Bloodpressurecontrol:saltgetsunderyourskin.NatMed.200915:487‐488.68. GongoraMC,HarrisonDG.NOsolutionforaradicalproblem:Atalstory.AmJPhysiolRenalPhysiol.2010;2010,

298:F883‐884.69. RichMW,MensahGAandPriceVInvestigators.Fifthpivotalresearchincardiologyintheelderly(PRICE‐V)

symposium:Preventivecardiologyintheelderly‐‐executivesummary.Partii:Afternoonsession.PrevCardiol.2010;13:42‐47.

70. RichMW,MensahGAandPriceVInvestigators.Fifthpivotalresearchincardiologyintheelderly(PRICE‐V)symposium:Preventivecardiologyintheelderly‐executivesummary.Parti:Morningsession.PrevCardiol.2009;12:198‐204.

24

71. HarrisonDG,VinhA,LobH,MadhurMS.Roleoftheadaptiveimmunesysteminhypertension.CurrOpinPharmacol.2010,10:203‐207.

72. HarrisonDG,Chen,W,DikalovS,LiL.RegulationofEndothelialCellTetrahydrobiopterin:Pathophysiologicalandtherapeuticimplications.AdvancesinPharmacology.2010,60:107‐132.

73. HarrisonDG,GuzikTJ,LobH,MadhurM,MarvarPJ,ThabetS,VinhA,WeyandC.Inflammation,Immunity,andHypertension.Hypertension.2011,57:132‐140.

74. MarvarPJ,LobH,VinhA,ZarreenF,HarrisonDG.Thecentralnervoussystemandinflammationinhypertension.CurrOpinPharmacol.2011,11:156‐161.

75. HarrisonDG.JustNotHimselfTheseDays:AninvitationtosubmitpapersonthetopicofInflammationandImmunityinOrganSystemsPhysiologyandPathophysiology.AmJPhysiolRegulIntegrCompPhysiol.2011,300:R1263‐1265.

76. MajorAS,HarrisonDG.Whatfansthefire:insightsintomechanismsofinflammationinatherosclerosisanddiabetesmellitus.Circulation.201,124:2809‐2811.

77. CowleyAWJr,NadeauJH,BaccarelliA,BerecekK,FornageM,GibbonsGH,HarrisonDG,LiangM,NathanielszPW,O'ConnorDT,OrdovasJ,PengW,SoaresMB,SzyfM,TolunayHE,WoodKC,ZhaoK,GalisZS.ReportoftheNationalHeart,Lung,andBloodInstituteWorkingGrouponEpigeneticsandHypertension.Hypertension.2012, 59:899-905

78. RoleoftheRenin‐AngiotensinSysteminthePathogenesisofIntimalHyperplasia:TherapeuticPotentialforPreventionofVeinGraftFailure?OsgoodMJ,HarrisonDG,SextonKW,HockingKM,VoskresenskyIV,KomalavilasP,Cheung‐FlynnJ,GuzmanRJ,BrophyCM.AnnVascSurg.2012, 26:1130-1144

79. HarrisonDG,MarvarPJ,TitzeJM.VascularInflammationinHypertension.FrontPhysiol.2012,3:1‐8.80. HarrisonDG,GuzikTJ.StudiesoftheT‐cellAngiotensinreceptorusingcre‐loxtechnology:anunan‐T‐cellpated

result.CircRes.2012,110:1543‐1545.81. MarvarPJ,HarrisonDG.Stress‐dependenthypertensionandtheroleofTlymphocytes.ExpPhysiol.2012,

22:1161‐116782. Dikalov SI, Harrison DG. Methods for detection of mitochondrial and cellular ROS. Antioxid Redox Signal. 2012 in

press

83. Hasty AH, Harrison DG. Endoplasmic reticulum stress and hypertension - a new paradigm? J Clin Invest. 2012, 122:3859-3861

84. Madhur MS, Harrison DG. Synapses, Signals, CDs, and Cytokines: Interactions of the Autonomic Nervous System and Immunity in Hypertension. Circ Res. 2012, 111:1113-1116

85. Harrison DG. The Mosaic Theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension. Journal of the American Society of Hypertension. 2013, 7:68-74

86. Itani HA, Dikalov S, Harrison DG. Knock, knock: Who’s there? Nox1: Circulation. 2013, 127:1850-1852

87. MadhurMS,HarrisonDG.SenescentTCellsandHypertension:NewIdeasAboutOldCells.Hypertension.2013,62:13-15

88. Harrison DG. From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production. J Clin Invest. 2014;124:473-475.

89. Trott DW, and Harrison DG. The immune system in hypertension. Adv Physiol Educ. 2014;38:20-24.

C. Symposiumcontributions:

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1. HarrisonDG.Interactionsofnitricoxide,superoxideandsuperoxidedismutaseinthevesselwall:contributionstoregulationofvasomotion.1997,CoronaryMicrocirculationduringIschemiaandReperfusion,AlfredBenzonSymposium41:173‐188.

D. BooksandBookchapters:

1. MarcusML,KoyanagiS,HarrisonDG,HiratzkaLF,WrightCD,DotyDB,EasthamCL.Abnormalitiesinthe

CoronaryCirculationSecondarytoCardiacHypertrophy.In:PerspectivesinCardiovascularResearch,Tarai,RC.andDunbar,JB.(Eds.),RavenPress,NewYork,Vol,8,1983,pp.273‐285.

2. HarrisonDG,MarcusML.TheClinicalDiagnosisofRightVentricularInfarction.In:AcuteMyocardialInfarction,

MartinusNijhoff.

3. HarrisonDG.PostThrombolyticCare.In:AcuteCoronaryCare,Wagner,GS.(Ed.),MartinusNijhoffPublishing,Boston,1986.

4. HeistadDD,HarrisonDG,ArmstrongML.SerotoninandExperimentalVascularDisease.In:InternationalJournal

ofCardiology,Frye,RL(Ed.),ElsevierSciencePublisher,Amsterdam,1987,pp.205‐212.

5. HarrisonDG,GuerraR,FreimanPC,ArmstrongML.ImpairedEndothelium‐DependentMechanismsinAtherosclerosis.In:ResistanceArteries,HalpernW,PegramBL,BraydenJE,MackeyK,McLaoughlinMK,andOsolG(Eds),PerinatologyPress,Ithaca,NewYork,1988,pp.54‐67.

6. HeistadDD,ArmstrongML,BrownB,HarrisonDG.ResponsivenesstoSerotonininAtheroscleroticBlood

Vessels.In:Vasodilatation:VascularSmoothMuscle,Peptides,AutonomicNerves,andEndothelium,VanhoutteP(Ed.),RavenPress,NewYork,1988,pp.245‐259.

7. HarrisonDG.AtherosclerosisAltersEndothelium‐DependentResponsestoaVarietyofNeurohumoralAgents:

PotentialMechanismsandPathophysiologicConsequences.In:Vasodilatation:VascularSmoothMuscle,Peptides,AutonomicNerves,andEndothelium,VanhoutteP(Ed.),RavenPress,NewYork,1988,pp.517‐521.v.

8. HarrisonDG,GuerraRJr.,FreimanPC,ArmstrongML.In:ImpairedEndothelium‐DependentMechanismsin

Atherosclerosis.ProceedingoftheSymposiumonResistanceVessels,PerinatologyPress,Ithaca,NewYork,1988,pp.54‐58.

9. ArmstrongML,HeistadDD,MeganMB,LopezJAG,HarrisonDG.ReversibilityofAtherosclerosis.In:Preventive

AspectsofCoronaryHeartDisease,Frohlich,Ed.,andBrest,AN.(Eds.),F.A.DavisCompany,1990,pp.113‐126.

10. HarrisonDG,MinorRL,GuerraR,QuillenJE,SellkeFW.EndothelialDysfunctioninAtherosclerosis.In:CardiovascularSignificanceofEndothelium‐DerivedVasoactiveFactors.Editor,RubanyiR,263‐280,FuturaPublishingCo.,1990.

11. HarrisonDG.EndothelialRegulationofVasomotorToneinAtherosclerosis.In:Atherosclerosis:Cellularand

MolecularInteractionsintheArteryWall.Editors,GotliebAI,LangilleBL,FedoroffS,pp.153‐160,PlenumPress,1990.

12. HarrisonDG.NeurohumoralandPharmacologicRegulationofCollateralPerfusion.In:CollateralCirculation.

Editors,SchaperWandSchaperJ,pp.329‐343,KluwerAcademicPublishers,1993.

13. HarrisonDG.EndothelialDysfunctioninAtherosclerosis.In:Arteriosclerosis.JustH,HortW,ZeiherAM(Eds.),SteinkipffVerlagDarmstadt,1994,pp.87‐102.

14. HarrisonDG,KurzS,TarpeyM,FreemanB,andMünzelT.IncreasedVascularSuperoxideProduction:ANovel

MechanismUnderlyingNitrateTolerance.In:NitratesinCardiovascularDisease.

26

15. HarrisonDG.Interactionsofnitricoxide,superoxideandsuperoxidedismutaseinthevesselwall:contributionstoregulationofvasomotion.CoronaryMicrocirculationDuringIschemiaandReperfusion.HaunsøS,AldershvileJ,SvendsenJ(Eds.).Munksgaard,Copenhagen1997,pp.173‐194.

16. GriendlingKK,HarrisonDG.AngiotensinII,oxidativestressandnitricoxide.In:Levin,E.R.andNadler,J.,eds.

EndocrinologyofCardiovascularFunction,Norwell:KluwerAcademicPublishers,1998,pp79‐98.17. HarrisonDG,GalisZ,ParthasarathyS,GriendlingKK.Oxidativestressandhypertension.HypertensionPrimer,

Baltimore:Lippincott,Williams&Wilkins,1999,pp163‐166.

18. ZafariAM,HarrisonDG,GriendlingKK.VascularOxidantStressandNOBioactivity.In:RichardO.CannonandJulioA.Panza,eds.,Endothelium,NitricOxide,andAtherosclerosis,FuturaPublishingCompany,1999,pp133‐144.

19. SomersMJ,GriendlingKK,HarrisonDG.Theroleofoxidativestressinhypertension.Keaney,JF,Jr.,ed.

OxidativeStressandVascularDisease,Norwell:KluwerAcademicPublishers,1999.

20. GriendlingKK,HarrisonDG,AlexanderRW.Molecularandcellularbiologyofbloodvessels.In:FusterV,AlexanderRW,andO’RourkeRA,eds.Hurst’sTheHeart,NewYork:McGraw‐Hill,2001,Chapter6.

21. HarrisonDG,GalisZ,ParthasarathyS,GriendlingKK.Oxidativestressandhypertension.HypertensionPrimer,

Baltimore:Lippincott,WilliamsandWilkins,2003,pp185‐188.22. GriendlingKK,HarrisonDG,AlexanderRW.Biologyofthevesselwall.In:FusterV,AlexanderRW,andO’Rourke

RA,eds.Hurst'sTheHeart,NewYork:McGraw‐Hill,2004,pp135‐154.

23. GriendlingKK,HarrisonDG,AlexanderRW.Molecularandcellularbiologyofbloodvessels.In:FusterV,AlexanderRW,andO’RourkeRA,eds.Hurst’sTheHeart,NewYork:McGraw‐Hill,2005,Chapter7.

24. HarrisonDG,DoughanAR,SellkeFW.PhysiologyoftheCoronaryCirculation.In:SellkeFrank,delNidoPedroJ,

SwansonScottJ,eds.SurgeryoftheChest,NewYork:ElsevierSaunders,2005,pp753‐765.

25. VoisineP,WykrzykowskaJJ,BoodhwaniM,HarrisonDG,LahamRJ,SellkeFW.In:LahamR,BaimD,eds.TheCoronaryMicrocirculationandAngiogenesis,Totowa,NJ:HumanaPress,2005,Chapter4,pp..065‐106.

26. DikalovS,HarrisonDG.PharmacologicalCompoundswithAntioxidantActivity.In:Bourassa,MartialG.;Ta