CURRICULUM VITAE Eric M. Snyder, PhD

Academic Rank and Position Assistant Professor Director, Clinical Exercise Physiology Laboratory Department of Kinesiology College of Education and Human Development University of Minnesota, Twin Cities

Education Degree Institution Date Degree Granted

Bachelor of Science, Missouri Southern State University 1996-2000 Major: Health Promotion and Wellness Minors: Athletic Training, Management, Coaching Mayo Clinic, Cardiovascular Diseases, Internship 2000 Cardiac Rehabilitation, Phases I-IV Masters of Science, University of Wisconsin, La Crosse 2000-2001 Exercise Science Doctor of Philosophy, University of Minnesota 2001-2005 Exercise Physiology Mayo Clinic College of Medicine 2003-2004 Visiting Graduate Student, Cardiovascular Diseases Mentor: Bruce D. Johnson, PhD Mayo Clinic College of Medicine 2004-2005 Pre-Doctoral Fellow, Cardiovascular Diseases Mentor: Bruce D. Johnson, PhD Mayo Clinic College of Medicine 2005-2006 Post-Doctoral Fellow, Cardiovascular Diseases Mentor: Bruce D. Johnson, PhD Mayo Clinic College of Medicine 2006-2007 Post-Doctoral Fellow, Nephrology and Hypertension Mentor: Stephen T. Turner, MD

Licenses and Certifications

Basic Life Support 2009-present Advanced Cardiac Life Support 2009-present Previous Professional Positions and Major Appointments

2007-2012 Assistant Professor, Director Clinical Research Laboratory University of Arizona College of Pharmacy 2007-2010 Collaborating Research Scientist, Mayo Clinic 2007 Assistant Professor of Medicine,

Mayo Clinic College of Medicine 2005-2007 Post-Doctoral Fellow, Mayo Clinic College of Medicine 2003-2008 Adjunct Instructor, Winona State University 2002-2005 Pre-Doctoral Fellow, Mayo Clinic College of Medicine 2002-2003 Lecturer, Winona State University Current Memberships in Professional Organizations

2001 American College of Sports Medicine 2002 American Physiological Society, Full Member 2002 American Thoracic Society 2002 American Heart Association, Fellow 2008 American Association of Colleges of Pharmacy 2008 American College of Clinical Pharmacy 2008 Arizona Physiological Society 2009 American Association for the Advancement of Science 2009 American Society for Clinical Pharmacology and Therapeutics

HONORS AND AWARDS FOR RESEARCH/CREATIVE WORK, TEACHING, PUBLIC ENGAGEMENT, AND SERVICE

2011 Fellow, American Heart Association 2011 Member, Communications Committee, American Physiologic Society 2008 Member ACTREC Clinical Scholars Circle, Health Research Alliance of

Arizona 2006 Training Award (T32) Nephrology and Hypertension Mayo Clinic College of Medicine 2005 Highlighted Abstract: International Hypoxia Symposium. 2004 Highlighted Abstract: American Thoracic Society Annual Meeting 2004 Fellowship Grant Award, Division of Kinesiology, University of Minnesota

Visiting Professorships Research Scholar, Visiting Professor 2008-present Mayo Clinic College of Medicine

RESEARCH, SCHOLARSHIP, AND CREATIVE WORK Grants and Contracts

Current Research Support: (Snyder, PI, 40%) 06/10/2011-05/30/2017 National Institutes of Health (1RO1H2108962) ($2,235,750) “Gene-by-Gene Interactions and Lung Fluid Balance in Patients with Heart

Failure” Completed Research Support:

(Fernando Martinez, PI, 10%) 01/01/2012-12/31/2017 National Institutes of Health (R01 HL056177-16) ($5,901,116) “Childhood Predictors of Airway Structure, Function and Disease in Adult Life (Snyder, PI, 15%) 01/01/2011-12/31/2011 WestMed Respiratory Device Corporation years ($113,100) “Comparison Between the VibraLung Device and Vest Physiotherapy and

Pulmonary Function in Patients with Cystic Fibrosis” (Snyder, Co-PI) 05/01/2010-05/01/2011 Arizona Biomedical Research Commission ($333,203) RFP NO. FY09-100 “Effect of Diabetes on Pulmonary Vascular Control: Consequences of increased

Altitude” (CJ Baldi, Co-Investigator) 05/01/2009-12/31/2010 National Institutes of Health (R15) ($150,000) “Pulmonary Vascular Control at Moderate Altitude in Patients with Type-I

Diabetes”. (Snyder, PI) 01/01/2009-12/31/2009 WestMed Respiratory Device Corporation ($33,116) “Evaluation of efficacy of the VibraLung Device in Chest Clearance in Cystic

Fibrosis”

(Snyder, PI) 04/01/2008-03/30/2009 University of Arizona Foundation ($9,968) Faculty Small Grant Award “Quantification of Exhaled Condensate Using Bronchoalveolar Lavage in Cystic

Fibrosis” (Snyder, PI) 01/01/2008-12/31/2009 Arizona Clinical and Translational ($50,000) Research and Education Consortium (ACTREC) “Modifying Genes in Cystic Fibrosis: The Beta-2 Adrenergic Receptors and

Epithelial Na+ Channels”. (T32, Institutional Training Grant) National Institutes of Health Training Grant 11/01/2006-10/31/2008 Department of Nephrology and Hypertension, Mayo Clinic ($90,772) “Polygenic Regulation of Renal Na+ Handling”. (Snyder, PI) AHA 05-25727Z 07/01/2005-06/30/2007 American Heart Association, Post-Doctoral Fellowship ($85,044) “Beta-2 Adrenergic Receptor Polymorphisms and Lung Fluid Balance in Heart Failure”. (Snyder, PI) AHA 04-10073Z 01/01/2004-12/31/2005 American Heart Association, Pre-Doctoral Fellowship ($49,000) “Influence of Beta-2 Adrenergic Receptor Genotype on Lung Fluid Balance in Healthy Humans”. Publications (*student author under Dr. Snyder’s direction)

Refereed Journal Articles: 1. Courtney M. Wheatley, Eric M. Snyder, Bruce D. Johnson, and Thomas P.

Olson. Sex Differences in Cardiovascular Function During Submaximal Exercise in Humans. SpringerPlus. Aug 20; 3:445. 2014. (PMID:25191635) 2. Eric M. Snyder and Bruce D. Johnson. Importance of the kidney, vessels, and

heart with administration of β2 Adrenergic Receptor Agonists in Patients Susceptible to Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine. 189(11): 1445-7. 2014. (PMID: 2488197).

3. *Ben J. Peterson, John S. Fitzgerald, Calvin C. Dietz, Kevin S. Ziegler, Stacy J. Ingraham, Sarah E. Baker, & Eric M. Snyder. The Relationship Between Aerobic Capacity (VO2peak) and Repeated Shift Performance in Competitive Hockey Players. Submitted to: Journal of Strength and Conditioning Research. In-press. 4. *Ben J. Peterson, John S. Fitzgerald, Calvin C. Dietz, Kevin S. Ziegler, Stacy J. Ingraham, Sarah E. Baker, & Eric M. Snyder. On- and off-ice performance markers of college hockey players, stratified by division of play. Submitted to: Journal of Strength and Conditioning Research. In-press 5. *Courtney M. Wheatley, Nicholas A. Cassuto, William T. Foxx-Lupo, Cori M. Daines, Wayne J. Morgan, Hanna Phan, and Eric M. Snyder. Exhaled Breath

Condensate Detects Reductions in Chloride and Increases in Response to Albuterol in Patients with CF. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine. Dec 10;7:79-90. 2013. (PMID: 24367235) 6. *Courtney M. Wheatley, Eric M. Snyder, Michael J. Joyner, Bruce D. Johnson, and Thomas P. Olson. Comparison of Intra-arterial and Manual Ausculation of Blood Pressure During Submaximal Exercise in Humans. Submitted to: Applied Physiology, Nutrition, and Metabolism. May; 38(5) 537-44. 2013. (PMID 23668762) 7. Asad E. Patanwala, Hanna Phan, and Eric M. Snyder. Influence of Age On Opiate Therapy in the Emergency Department. Accepted in: Annals of Emergency Medicine. S0736-4679(12) 01422-9. 2013. (PMID: 23333181) 8. *Sarah E. Baker, Eric C. Wong, Courtney M. Wheatley, William T. Foxx-Lupo, Marina G. Martinez, Mary A. Morgan, Ryan Sprissler, Wayne J. Morgan, and Eric M. Snyder. Genetic Variation of SCNN1A Influences Lung Diffusing Capacity in Cystic Fibrosis. Submitted to: Medicine and Science in Sports and Exercise. 44(12) 2315-21. December, 2012 (PMID: 22776878) 9. Bryan J. Taylor, Eric M. Snyder, and Bruce D. Johnson. Hypobaric vs. Normobaric Hypoxia: The Lungs May be Different. Journal of Applied Physiology. 112(10) 1788-94. 2012. (PMID: 22589492) 10. *Micah W. Johnson, Bryan J. Taylor, Minelle L. Hulsebus, Bruce D. Johnson and Eric M. Snyder. Hypoxia Induced Changes in Lung Fluid Balance in

Humans is Associated with Beta-2 Adrenergic Receptor Density on Lymphocytes. Submitted to: Respiratory Physiology and Neurobiology. 183(2). 159-65. August, 2012. (PMID: 22772314) 11. *Sarah E. Baker, Courtney M. Wheatley, Nicholas A. Cassuto, William T. Foxx-Lupo, and Eric M. Snyder. Genetic Variation of αENaC Influences Lung

Diffusion During Exercise in Humans. Respiratory Physiology and Neurobiology. Dec 15;179(2-3):212-8. 2011. (PMID: 21893217) 12. *William T. Foxx-Lupo, Courtney M. Wheatley, Nicholas A. Cassuto, Nicholas A. Delamere, and Eric M. Snyder. Genetic Variation of the Alpha Subunit of the Epithelial Na+ Channels Influences Exhaled Na+ in Healthy Humans. Respiratory Physiology and Neurobiology. Dec 15;179(2-3):205-11. 2011 (PMID: 21889619) 13. *Brittany R. Traylor, Courtney M. Wheatley, Thomas T. Skrentny, Jr., William T. Foxx-Lupo, Hanna Phan, Asad E. Patanwala, Wayne J. Morgan, Cori L. Daines, and Eric M. Snyder. Influence of Genetic Variation of the β2-Adrenergic Receptor on Lung Diffusion in Patients with Cystic Fibrosis. Pulmonary Pharmacology and Therapeutics. 24(5) 610-6. 2011 (PMID: 21703359) 14. Bryan J. Taylor, Jesper Kjaergaard, Eric M. Snyder, Thomas P. Olson, and Bruce D. Johnson. Pulmonary Capillary Recruitment in Response to Hypoxia in Healthy Humans: Potential Role for Hypoxic Pulmonary Venoconstriction. Respiratory Physiology and Neurobiology. Jul 31;177(2):98-107. 2011 (PMID: 21513822) 15. *Courtney M. Wheatley, Brad W. Wilkins, and Eric M. Snyder. Exercise is Medicine in Cystic Fibrosis. Exercise and Sport Science Reviews. Jul;39(3):155-60. 2011 (PMID: 21383626) 16. Eric M. Snyder, Eric C. Wong, William T. Foxx-Lupo, Courtney M. Wheatley, Nicholas A. Cassuto, and Asad E. Patanwala. Influence of an Inhaled β-agonist on Cardiovascular Function and Sympathetic Activity in Healthy Humans. Pharmacotherapy. 31(8):748-756. 2011 (PMID: 21923601) 17. *Courtney M. Wheatley, William T. Foxx-Lupo, Nicholas A. Cassuto, Eric C. Wong, Cori L. Daines, Wayne J. Morgan, and Eric M. Snyder. Impaired Alveolar-Capillary Membrane Conductance Results in Oxygen Desaturation During Exercise in Patients with Cystic Fibrosis. Journal of Cystic Fibrosis. 10(1):45-53. 2010. (PMID: 21050829) 18. *Courtney M. Wheatley, James C. Baldi, Nicholas A. Cassuto, William T. Foxx-Lupo, and Eric M. Snyder. Glycemic Control Influences Lung Membrane Diffusion and Oxygen Saturation in Exercise-Trained Subjects with Type 1 Diabetes. European Journal of Applied Physiology. Oct 10. 2010. (PMID: 20936482) 19. Eric M. Snyder. Complexity of Genetics in the Athlete Phenotype. Journal of

Human Genetics. 55:477-478. 2010. (PMID: 20613767) 20. *Courtney M. Wheatley, Nicholas A. Cassuto, William T. Foxx-Lupo, and Eric M. Snyder. Variability in Measures of Exhaled Breath Na+ and K+, Influence of

Pulmonary Blood Flow and Saliva. Clinical Medicine Insights: Circulatory, Respiratory, and Pulmonary Medicine. 4:25-34. 2010. (PMID: 21157525) 21. James C. Baldi, Nicholas A. Cassuto, William T. Foxx-Lupo, Courtney M. Wheatley, and Eric M. Snyder. Glycemic Control Improves Cardiopulmonary Exercise Response in Highly Trained Type I Diabetic Subjects. Medicine and Science in Sports and Exercise. 42(8): 1454-1459. 2010. (PMID: 20139786) 22. Maile L. Ceridon, Eric M. Snyder, Nicholas A. Strom, Juerg Tschirren, and Bruce D. Johnson. Influence of Rapid Fluid Loading on Airway Structure and Function in Normal Humans. Journal of Cardiac Failure. Feb;16(2):175-185. 2010. (PMID: 20142030) 23. Norman R. Morris. Eric M. Snyder, Kenneth C. Beck, and Bruce D. Johnson.

Lung-to-lung circulation times during exercise in heart failure. European Journal of Applied Physiology. 106: 621-627. 2009. (PMID: 19381678) 24. Sophie Lalande, Eric M. Snyder, Thomas P. Olson, Minelle L. Hulsebus,

Marek Orban, Virend K. Somers, Bruce D. Johnson, Robert P. Frantz. The Effects of Sildenafil and Acetazolamide on Breathing Effeciency During Hypoxic Exercise. European Journal of Applied Physiology. 106: 509-515. 2009. (PMID: 19337745) 25. Eric M. Snyder, Richard D. Carr, Carolyn F. Deacon, and Bruce D. Johnson.

Influence of Hypoxia on Plasma Glucagon-Like Peptide-1 and Leptin Levels in Humans. Applied Physiology, Nutrition, and Metabolism. 33(5): 929–935. 2008. (PMID: 18923568) 26. Eric M. Snyder, Thomas P. Olson, Bruce D. Johnson, and Robert P. Frantz. Influence of Sildenafil on Lung Diffusion during exposure to acute hypoxia at rest and during exercise in healthy humans. European Journal of Applied Physiology. 103(4):421-30. 2008. (PMID: 18369657) 27. Yuan Ji, Eric M. Snyder, Brooke L. Fridley, Oreste E. Salavaggione, Irene

Moon, Anthony Batzler, Vivien C. Yee, Daniel J. Schaid, Michael J. Joyner, Bruce D. Johnson and Richard M. Weinshilboum. Human phenylethanolamine N-methyltransferase (PNMT) genetic polymorphisms and exercise-induced epinephrine release. Physiological Genomics. 33(3):323-32. 2008. (PMID: 18349382) 28. Eric M. Snyder, Bruce D. Johnson, and Michael J. Joyner. Genetics of β2 Adrenergic Receptors and the Cardiopulmonary Response to Exercise. Exercise and Sport Sciences Reviews. 36(2) 98-105. 2008. (PMID: 18362692) 29. Jesper Kjaergaard, Eric M. Snyder, Christian Hassager, Robert Frantz, Thomas P. Olson, Jae K. Oh, and Bruce D. Johnson. Right Ventricular Function

at Exercise During Hypoxia: Effects of Sildenafil. European Journal of Applied Physiology. 102(1): 87-95. 2007. (PMID: 17909844) 30. Eric M. Snyder, Thomas P. Olson, and Bruce D. Johnson. Genetics and

Pharmacogenetics in Heart Failure. Current Heart Failure Reports. 4(3): 139-144. 2007. (PMID: 17883989) 31. Norman R. Morris, Eric M. Snyder, Kenneth C. Beck, Luke J. Haseler, Lyle

J. Olson, and Bruce D. Johnson. Resting Circulation Time Measured using a Soluble Gas Technique as a Predictor of Exercise Capacity in Chronic Heart Failure. Journal of Cardiac Failure. Jun;13(5):389-94. 2007. (PMID: 17602986) 32. Eric M. Snyder, Kenneth C. Beck, Stephen T. Turner, Eric A. Hoffman, Michael J. Joyner, and Bruce D. Johnson. The Arg16Gly Polymorphism of the β2 Adrenergic Receptor is Associated with Differences in Lung Fluid Accumulation in Healthy Humans. The Journal of Applied Physiology. 102 (6): 2172-2178. 2007. (PMID: 17347382) 33. Thomas P. Olson, Eric M. Snyder, Robert P. Frantz, Steven T. Turner, and Bruce D. Johnson. Repeat Length Polymorphism of the Serotonin Transporter Gene Influences Pulmonary Artery Pressure in Heart Failure. American Heart Journal, 2007 Mar;153(3):426-32. (PMID: 17307423) 34. Morten Dalsgaard, Eric M. Snyder, Jesper Kjaergaard, Jae K Oh, Christian

Hassager, and Bruce D. Johnson. Isovolumic acceleration measured by tissue doppler echocardiography is preload independent in healthy subjects. Echocardiography Jul;24(6):572-9. 2007. (PMID: 17584196)

35. Eric M. Snyder, Jan Stepanek, Sheryl L. Bishop, and Bruce D. Johnson. Ventilatory Responses to Hypoxia and High Altitude During Sleep in Aconcagua Climbers. Wilderness and Environmental Medicine. June; 18(2): 138-145. (PMID: 17590060) 36. Robert Wolk, Eric M. Snyder, Virend K. Somers, Stephen T. Turner, Lyle J.

Olson, and Bruce D. Johnson. Arg16Gly β2-Adrenoceptor Polymorphism and Cardiovascular Structure and Function in Subjects with Heart Failure. The Journal of the American Society of Echocardiography. March; 20(3): 290-297. 2007. (PMID: 17336757) 37. Eric M. Snyder, Stephen T. Turner, and Bruce D. Johnson. The Role of

Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel in Beta-Receptor Mediated Regulation of Alveolar Fluid Clearance. Journal of Applied Physiology. Jul;103(1):414.2007. 38. Thomas P. Olson, Robert P. Frantz, Eric M. Snyder, Kathy A. O’Malley, Kenneth C. Beck, and Bruce D. Johnson. Effects of Acute Changes in Pulmonary

Wedge Pressure on Periodic Breathing at Rest in Heart Failure Patients. American Heart Journal. January; 153(1):104.e1-7. 2007. (PMID: 17174646) 39. Eric M. Snyder, Stephen T. Turner, and Bruce D. Johnson. Beta-2

Adrenergic Receptor Genotype and Pulmonary Function in Patients with Heart Failure. CHEST. 130. 1527-1534. 2006. (PMID: 17099033) 40. Thomas P. Olson, Eric M. Snyder, and Bruce D. Johnson. Exercise

Disordered Breathing in Chronic Heart Failure. Exercise and Sports Science Reviews. 34(4) 194-201. 2006. (PMID: 17031258) 41. Jesper Kjaergaard, Eric M. Snyder, Christian Hassager, Thomas P. Olson,

Jae K. Oh, and Bruce D. Johnson. Effect of Simulated High Altitude on Left Ventricular Function. European Journal of Applied Physiology. 98(4) 411-418. 2006. (PMID: 17016703) 42. Eric M. Snyder, Kenneth C. Beck, Minelle L. Hulsebus, Jerome F. Breen, Eric A. Hoffman, and Bruce D. Johnson. Short-term Hypoxic Exposure at Rest and During Exercise Reduces Lung Water in Healthy Humans. Journal of Applied Physiology. 101(6) 1623-1632. 2006. (PMID: 16902060) 43. Kenneth C. Beck, Lakesha N. Randolph, Kent R. Bailey, Christina M. Wood, Eric M. Snyder, and Bruce D. Johnson. Relationship between Cardiac Output and Oxygen Consumption During Upright Cycle Exercise in Healthy Humans. Journal of Applied Physiology. 101(5) 1474-1480. 2006. (PMID: 16873603) 44. John H. Eisenach, Darrell R. Schroeder, Tasha L. Pike, Cristopher P. Johnson, William G. Schrage, Eric M. Snyder, Bruce D. Johnson, Stephen T.

Turner, and Michael J. Joyner. Dietary Sodium Restriction and β2-adrenergic Receptor Polymorphism Modulate Cardiovascular Function in Humans. The Journal of Physiology, London. 574(3) 955-965. 2006. (PMID: 16740612) 45. Eric M. Snyder, Stephen T. Turner, Michael J. Joyner, John H. Eisenach, and Bruce D. Johnson. The Arg16Gly Polymorphism of the Beta-2 Adrenergic Receptor and the Natriuretic Response to Rapid Saline Infusion. The Journal of Physiology, London. 574(3) 947-954. 2006. (PMID: 16728452) 46. Lyle J. Olson, Kenneth C. Beck, Eric M. Snyder, and Bruce D. Johnson.

Reduced Rate of Alveolar-Capillary Recruitment and Fall of Pulmonary Diffusing Capacity During Exercise in Patients with Heart Failure. The Journal of Cardiac Failure. 12(4). 2006. (PMID: 16679264) 47. Eric M. Snyder, Minelle L. Hulsebus, Stephen T. Turner, Michael J. Joyner, and Bruce D. Johnson. Genotype Related Differences in Beta-2 Adrenergic Receptor Density Influence Cardiac Function in Healthy Humans. Medicine and Science in Sports and Exercise. 38(5):882-886, May 2006. (PMID: 16672841)

48. Zhong Liu, Sunni A. Barnes, Lynn A. Sokolnicki, Eric M. Snyder, Bruce D.

Johnson, Stephen T. Turner, Michael J. Joyner, and John H. Eisenach. Beta-2 Receptor Polymorphisms and the Forearm blood Flow Response to Mental Stress. Clinical Autonomic Research. 2006; 16(2): 105-112. (PMID: 16683069) 49. Jesper Kjaergaard, Eric M. Snyder, Christian Hassager, Jae OH, and Bruce D. Johnson. Impact of preload and after-load on global and regional right ventricular function and pressure: A quantitative echocardiography study. The Journal of the American Society of Echocardiography. 2006; 19(5):515-21. (PMID: 16644434) 50. Eric M. Snyder, Kenneth C. Beck, Michael J. Joyner, Niki M. Dietz, Stephen T. Turner and Bruce D. Johnson. Influence of Beta-2 Adrenergic Receptor Genotype on Airway Function During Exercise in Healthy Adults. Chest. 2006, 129(3) 762-770. (PMID: 16537879) 51. Eric M. Snyder, Kenneth C. Beck, Niki M. Dietz, John H. Eisenach, Michael

J. Joyner, Stephen T. Turner, and Bruce D. Johnson. Arg16Gly Polymorphism of the Beta-2 Adrenergic Receptor is Associated with Differences in Cardiovascular Function at Rest and During Exercise in Humans. The Journal of Physiology, London. 2006, 571(1) 121-130. (PMID: 16339181) 52. Eric M. Snyder, Bruce D. Johnson and Kenneth C. Beck. Comparison of

Diffusing Capacity of the Lung for Carbon Monoxide During Exercise: Open Circuit vs. Rebreathe Technique. The Journal of Applied Physiology. 2005, 99(5) 1981-1991. (PMID: 16024523) 53. Eric M. Snyder, Michael J. Joyner, Stephen T. Turner, and Bruce D. Johnson. Blood Pressure Variation In healthy Humans: A Possible Interaction With Beta-2 Adrenergic Receptor Genotypes and Renal Epithelial Sodium Channels. Medical Hypotheses. 2005, 65: 296-299. (PMID: 15922102) 54. Eric M. Snyder and Bruce D. Johnson. Βeta-2 Adrenergic Receptor

Genotype and Survival Among Patients Receiving β-blocker Therapy After an Acute Coronary Syndrome, Letter to the Editor. JAMA: The Journal of The American Medical Association. February 15th, 2006, 295(7). (PMID:16478895) 55. Justo Sierra-Johnson, Eric M. Snyder, and Bruce D. Johnson. Altitude Exposure Should Increase Serum Leptin Levels in Healthy Adults. Obesity Research. 2005, March.13(3):635-6. (PMID: 15833950)

Manuscripts Under Review: 1. Natalie E. Taylor, Eric M. Snyder, Sarah E. Baker, Thomas P. Olson, Sophie Lalande, and Bruce D. Johnson. Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans. Submitted to: Respiratory Research. 2. *Marina G. Martinez, Courtney M. Wheatley, Sarah E. Baker, Nicholas A. Cassuto, Ryan Sprissler, William T. Foxx-Lupo, Eric C. Wong, and Eric M. Snyder. Genetic Variation of Phenylethanolamine-N-Methyltransferase

Influences Cardiovascular Function in Healthy Humans. Submitted to: Journal of Applied Physiology, Nutrition and Metabolism. 3. Sarah E. Baker, William T. Foxx-Lupo, Courtney M. Wheatley, Mary A. Morgan, Glenda Drake, Kathleen Miller, Hanna Phan,

Wayne J. Morgan, Cori L. Daines, Mark A. Brown, Ryan Sprissler, and Eric M. Snyder. Gentic Variation of

the Alpha Subunit of the Epithelial Sodium Channel Influences Pulmonary Function and Body Mass Index in Patients with Cystic Fibrosis. Submitted to: Journal of Cystic Fibrosis. 4. Courtney M. Wheatley, Sarah E. Baker, Mary A. Morgan, Marina G. Martinez, Wayne J. Morgan, Eric C. Wong, Stephen Karpen and Eric M. Snyder. Effects

of Exercise Intensity on Pulmonary Function in Patients with Cystic Fibrosis. Submitted to: Medicine and Science in Sports and Exercise.

5. Manda L. Keller-Ross, Thomas P. Olson, Eric M. Snyder, and Bruce D.

Johnson. Pulmonary Systolic Pressure and Exhaled Nitric Oxide in Response to Normobaric Hypoxia in Healthy Adults. Submitted to: PLOS One.

6. Ben J. Peterson, John S. Fitzgerald, Calvin C. Dietz, Kevin S. Ziegler, Sarah E. Baker, & Eric M. Snyder. Off-Ice Anaerobic Power is Not a Good Predictor of On-Ice Repeated Shift Performance in Hockey Players. Submitted to: Journal of Strength and Conditioning Research.

Presentations

Invited Presentations Cystic Fibrosis: Insight into Importance of Ion Regulation in the Development and Treatment of the Disease. Department of Physical Therapy. July 2014. Mechanisms by Which Exercise Acts as Therapy for Patients with Cystic Fibrosis. Pediatric Grand Rounds. University of Minnesota Fairview Medical Center. April 2014.

Cystic Fibrosis: Pediatric Pulmonology and Exercise Physiology in CF. Pediatric Exercise Physiology. Department of Kinesiology, University of Minnesota. April 2014. Cystic Fibrosis: Pathways in Which Exercise can Ameliorate the Drying of the Lung in CF. Seminar: Exercise Physiology. Kinesiology 8122, University of Minnesota, Fall 2013. Exercise and Cystic Fibrosis. Pediatric Physiology and Health, Concepts and Applications. Kinesiology 5585 University of Minnesota. Summer, 2013. Exercise is Medicine in Cystic Fibrosis. Exercise for Disease Prevention and Management. Kinesiology 5385. University of Minnesota, Spring, 2013. Genetic Variation of the Alpha Subunit of the Epithelial Sodium Channel acts as a Disease Modifier in Cystic Fibrosis. Mayo Clinic College of Medicine, Biomedical Engineering Seminar, January 2012. Assessment of Ion Regulation in Cystic Fibrosis using Exhaled Breath Condensate. Arizona Respiratory Center Research Conference. January 8th 2011. Genetics and Lung Fluid Balance, Implications in Cystic Fibrosis. Presented to Pediatric Pulmonology Clinical Consortiuim, University of Arizona. October 27 th, 2008. Influence of Hypoxia on Leptin and GLP-1 Levels in Humans. Featured in the “Physiologic Adaptations to Intermittent Hypoxic Exposure” section of the Experimental Biology Annual Meeting. San Francisco, CA. April 4th, 2006. Influence of Hypoxia at rest and During Exercise on Pulmonary Capillary Blood Volume, Alveolar-Capillary Conductance, and Lung Fluid Balance. International Hypoxia Meeting, Alberta, Canada, 2005. Genetic Variation of the Beta-2 Adrenergic Receptor and Lung Fluid balance in Healthy Humans. Featured in the “Genetic Basis of Cardiopulmonary Disorders” section of the 35th Annual Meeting of the International Union of Physiological Sciences, San Diego CA, 2005.

Abstracts (presented at national and international meetings) 1. CM Wheatley, EM Snyder, MJ Joyner, BD Johnson. No sex difference in alveolar to arterial gas exchange during constant-load exercise in healthy active men and women. American College of Sports Medicine International Conference 2015. San Diego, CA.

2. *E Lee, E Van Iterson, S Baker, N Taylor, A Kasak1, EM Snyder. Foam rolling

decreases muscle soreness but has no effects on running performance. American College of Sports Medicine International Conference 2015. San Diego, CA. 3. *AJ Kasak, CM Wheatley, EM Snyder, SE Baker. Influence of Stroke Volume on Gas Exchange Estimate of Pulmonary Capacitance in Cystic Fibrosis Patients During Exercise. Experimental Biology 2015. Boston, MA. 4. *AL Bisch, SE Baker, CM Wheatley, EM Snyder. Influence of Circulating Catecholamines on Cardiovascular Function at Rest and During Exercise in Cystic Fibrosis. Experimental Biology 2015. Boston, MA. 5. *EH Van Iterson, CM Wheatley, SE Baker, EM Snyder. Relationship of VO2 with Cardiac Hemodynamics Improves During Exercise in Cystic Fibrosis Patients. Experimental Biology 2015. Boston, MA. 6. *EH Van Iterson, CM Wheatley, SE Baker, WJ Morgan, EM Snyder. Genetic Variation in ΔF508 CFTR Influences Cardiac Power and Stroke Work in Cystic Fibrosis Patients. American Thoracic Society International Conference 2015. Denver, CO. 7. *EH Van Iterson, CM Wheatley, SE Baker, EM Snyder. The Capacity for Gas

Transfer Within Lungs Does Not Influence the Relationship Between Oxygen Uptake and Cardiac Hemodynamics During Exercise in Cystic Fibrosis Patients. American Thoracic Society International Conference 2015. Denver, CO. 8. *EH VanIterson, EM Snyder, BD Johnson, TP Olson. Pulmonary Vascular Response to Metaboreflex Stimulation During Submaximal Exercise In Heart Failure. American Heart Association, Scientific Sessions 2014. Chicago, IL. 9. *EH VanIterson, EM Snyder, MJ Joyner, BD Johnson, TP Olson. Effect of Locomotor Muscle Afferent Feedback Inhibition on Cardiac Power During Submaximal Exercise In Heart Failure. American Heart Association, Scientific Sessions 2014. Chicago, IL. **Recipient of AHA Trainee Travel Award. 10. *EH VanIterson, EM Snyder, MJ Joyner, BD Johnson, TP Olson. Influence of

Locomotor Muscle Afferent Feedback Inhibition on Pulmonary Vascular Conductance During Submaximal Exercise In Heart Failure. American Heart Association, Scientific Sessions 2014. Chicago, IL. 11. *EH VanIterson, EM Snyder, BD Johnson, TP Olson. Influence of Metaboreflex Stimulation on Cardiac Power and Stroke Work during Submaximal Constant-Load Exercise in Heart Failure. American College of Cardiology, 64 th

Annual Scientific Session and Expo, San Diego, CA. **Selected as a Finalist for Young Investigator Award. 12. *AJ Kasak, CM Wheatley, EM Snyder, SE Baker. Pulmonary Capacitance is

Lower in Patients with Cystic Fibrosis at Rest and During Peak Exercise. American College of Sports Medicine: 2014 Integrative Physiology of Exercise Conference, Miami, FL. 13. *CM Wheatley, Ma Morgan, SE Baker, EC Wong, SR Karpen, MG Martinez, WJ Morgan, EM Snyder. Moderate Intensity Exercise can Mediate Comparable

Increases in Exhaled Chloride as Albuterol in Patients with Cystic Fibrosis. North American Cystic Fibrosis 2013. Pediatric Pulmonology; 45:S36:345 abstract #385. Nominated for Junior Investigators Best Abstract in Clinical Research Award (top 5 finalist) 14. *CM Wheatley, SE Baker, CM Daines, H Phan, M Martinez, WJ Morgan, and EM Snyder. Influence of the VibraLung Device on Pulmonary Function and Sputum Expectoration in Patients with Cystic Fibrosis. North American Cystic Fibrosis 2013. Pediatric Pulmonology; 45:S36:357 abstract #416. 15. M Li, K Walsh, MG Martinez, SE Baker, EM Snyder, Asad E. Patanwala. Psychological and genetic predictors of pain tolerance. American Colleges of Clinical Pharmacy Annual Meeting, May 21st-22nd, 2013. Pharmacotherapy; 2013; 33:e79. 16. *MC McCue, CM Wheatley, MA Morgan, EC Wong, WJ Morgan, M Sattler, EM Snyder. Relationship Between Cardiac Output and Lung Function in Patients with Cystic Fibrosis. American College of Sports Medicine Annual Meeting, Indianapolis, Indiana, 2013. Medicine and Science in Sports and Exercise, Volume 45:5S Abstract 1274 17. *Courtney M. Wheatley, Mary A. Morgan, Sarah E. Baker, Eric C. Wong, Marina Martinez, Wayne J. Morgan, Eric M. Snyder. Comparison of the Effects of Varying Exercise Intensities vs. Albuterol on Pulmonary Function in Patients with Cystic Fibrosis. American College of Sports Medicine Annual Meeting, Indianapolis, Indiana, 2013. Medicine and Science in Sports and Exercise, Volume 45:5 S42 Abstract 254. 18. *MG Martinez, TP Olson, BD Johnson, EM Snyder. Cardiovascular Response to an Inhaled beta-agonist in Patients with Heart Failure, Effect of Beta-Blockade. Experimental Biology, Boston, MA, 2013. The FASEB Journal 2013, 27:1126.1125. 19. *SE. Baker, CM. Wheatley, AD. Miller, AJ. Kasak, AR. Carlson, BJ. Taylor, ML. Hulsebus, EM. Snyder, BD. Johnson..Influence of Inhaled Amiloride on

Lung Fluid Regulation During Normobaric Hypoxia in Healthy Humans. Experimental Biology, Boston, MA, 2013. The FASEB Journal 2013, 27:715.719. 20. *MC McCue, TP Olson, BD Johnson, EM Snyder, BA Borlaug. Relationship Between Cardiac Output Via Acetylene Rebreathing and Echocardiography in Heart Failure. Experimental Biology, Boston, MA, 2013. FASEB J. April 2013:27:711.5 21. *MC McCue, TP Olson, BD Johnson, EM Snyder, BA Borlaug. Relationship Between Oxygen Pulse and Echocardiography in Heart Failure with Preserved Ejection Fraction. Experimental Biology, Boston, MA, 2013. FASEB J. April 2013:27:711.4 22. *MC McCue, CM Wheatley, MA Morgan, EC Wong, WJ Morgan, TP Olson, EM Snyder. Comparison of Stroke Volume Estimation Using O2 Pulse and

Acetylene Rebreathe in Patients with Cystic Fibrosis. American Thoracic Society International Meeting, Philadelphia, PA, 2013. Am J Respir Crit Care Med. 187;2013:A4401 23. *MC McCue, SE Baker, CM Wheatley, MA Morgan, EC Wong, M Sattler, EM Snyder. Bronchodilation During Exercise in Patients with Cystic Fibrosis,

Comparison to Albuterol Administration. Integrative Biology of Exercise Annual Meeting, Westminster, CO, 2012. Published in: The Physiologist; 55(6), December 2012. 24. SE Baker, CM Wheatley, EM Snyder, MJ Joyner, BD Johnson, and TP Olson. Comparison of Intra-Arterial vs. Manual Ausculation of Blood Pressure During Exercise in Healthy Humans. American College of Sports Medicine Annual Meeting, San Francisco, CA, 2012. Published in: Medicine and Science in Sports and Exercise, Volume 44:5 Supplement Abstract 2056. 25. CM Wheatley, EM Snyder, BD Johnson, and TP Olson. Sex Differences in Cardiovascular function at Rest and During Submaximal Exercise in Healthy Humans. American College of Sports Medicine Annual Meeting, San Francisco, CA, 2012. Published in: Medicine and Science in Sports and Exercise, Volume 44:5 Supplement Abstract 1831. 26. WJ Morgan, DA Stern, EM Snyder, EC Wong, CM Wheatley, NA Cassuto, S Guerra, M Halonen, AL Wright and FD Martinez. The relation of early life total serum IgE to airway wall area in adult life. American Thoracic Society International Meeting, San Francisco, CA, 2012. Published in: American Journal of Respiratory and Critical Care Medicine. 2012. 185: 27. *S Lau, CM Wheatley, EC Wong, NA Cassuto, CL Daines, D Gilbertson, FD Martinez, WJ Morgan, and EM Snyder. CT-Derived Pulmonary Vascular Volume

and Lung Structure and Function in Humans. American Thoracic Society

International Meeting, San Francisco, CA, 2012. Published in: American Journal of Respiratory and Critical Care Medicine. 2012; 185: A2032. 28. *MG Martinez, SE Baker, CM Wheatley, EM Snyder. Genetic Variation of

Phenylethanolamine-N-Methyltransferase Does not Inlfuence the Catecholamines Response to Albuterol in Healthy Humans. Experimental Biology, San Diego, CA, 2012. Published in: FASEB J. 26 April 2012 (Meeting Abstract Supplement) lb659. 29. *WT Foxx-Lupo, CM Wheatley, SE Baker, PT Wojcik, and EM Snyder.

Influence of genetic variation of the alpha-subunit of the epithelial sodium channel (ENaC) on baseline pulmonary function and exhaled sodium ions (Na) and chloride ions (Cl) in healthy subjects and patients with cystic fibrosis. American Society of Health-System Pharmacists Mid-Year Meeting. New Orleans, LA, 2011. 30. *KK Herko, BT Guthrie, WJ Morgan, CM Wheatley, WT Foxx-Lupo, MA Morgan, CL Daines, H Phan, and EM Snyder. Genetic Variation of the Beta-2

Adrenergic Receptor and the Bronchodilatory Response to Albuterol in Patients with Cystic Fibrosis. North American Cystic Fibrosis Conference. Anaheim, CA, 2011. Pediatric Pulmonology. 46(S 34) p.273. 2011. 31. *AA Mohammed, CM Wheatley, NA Cassuto, and EM Snyder. Genetic Variation of Phenylethanolamine-N-methyltransferase Influences Cardiovascular Function in Healthy Humans. American Heart Association, Basic Cardiovascular Sciences July 2011 Scientific Sessions. Published in: Circulation Research; 109:AP101. 2011 32. *AA Bagalagal, HT Bakash, RM Diri, CM Wheatley, and EM Snyder. Genetic Variation of the Alpha Subunit of ENaC at Amino Acid 663 Influences Urine Na+ Handling in Healthy Humans. American Heart Association, High Blood Pressure Research 2011 Scientific Sessions. Orlando, FL, 2011. 33. *RG Pett, CM Wheatley, MA Morgan, EC Wong, WT Foxx-Lupo, CL Daines, W Morgan, and EM Snyder. Influence Of Genetic Variation Of The Alpha-Subunit Of ENaC On Lung Diffusion In Patients With Cystic Fibrosis. American Thoracic Society International Conference in Denver, Colorado. Am. J. Respir. Crit. Care Med., May 2011, 183: A1120. 34. *CM Wheatley, EC Wong, MW Johnson, WT Foxx-Lupo, W Morgan, and EM Snyder. Genetic Variation Of The Alpha-Subunit Of The Epithelial Na+ Channel Influences Lung Diffusion At Rest And During Exercise In Cystic Fibrosis. American Thoracic Society International Conference in Denver, Colorado. Am. J. Respir. Crit. Care Med., May 2011; 183: A1116.

35. B Taylor, ML Ceridon, EM Snyder and BD Johnson. Lung fluid balance in patients with heart failure: effect of β2 adrenergic-receptor stimulation. Experimental Biology, Washington, DC. FASEB J. 25. 104.5. 2011. 36. *SE Baker, CM Wheatley, NA Cassuto, EC Wong, WT Foxx-Lupo, and EM Snyder. Genetic Variation of the Alpha Subunit of ENaC Influences Lung

Diffusion during Peak Exercise. Experimental Biology, Washington, DC. FASEB J. 25. 862.1. 2011.

37.* MG Martinez, CW Wheatley, NA Cassuto, EC Wong, WT Foxx-Lupo, and EM Snyder, Genetic variation of the β2 adrenergic receptor influences the cardiovascular response to albuterol. Experimental Biology, Washington, DC. FASEB J. 25, 828.2. 2011.

31. *MG Martinez, CM Wheatley, NA Cassuto, WT Foxx-Lupo, and EM Snyder.

Glycemic Control Optimizes Resting Cardiovascular Function in Exercise-Trained Type I Diabetic Patients. AHSC Frontiers in Biomedical Research. University of Arizona. 2010. 38. *CM Wheatley, H Phan, M Morgan, EC Wong, NA Cassuto, WT Foxx-Lupo, CL Daines, WJ Morgan, and EM Snyder. Pharmacogenetics of the Alpha

Subunit of the Epithelial Na+ Channel on Exhaled Na+ in Response to Albuterol in Cystic Fibrosis. Pediatric Pulmonology. Supp. 33. P. 287. 2010 39. *CM Wheatley, H Phan, EC Wong, WT Foxx-Lupo, MMorgan, NA. Cassuto, WJ Morgan, C Daines, and EM. Snyder. Contribution of DLCO and DLNO Measures at Rest and Peak Exercise in Explaining Variability in Changes in Outpatient Therapy Secondary to Acute Exacerbations in Cystic Fibrosis. Pediatric Pulmonology. Supp. 33. P. 371. 2010. 40. BJ Taylor, EM Snyder, TP Olson, KA O’Malley and Johnson BD. Evidence

that hypoxia-induced pulmonary vasoconstriction in humans is primarily a post-capillary event. FASEB J. 2010 24:990.8. 41. *BR Traylor, T Skrentny, WT Foxx-Lupo, CM Wheatley, NA Cassuto, H Phan, CL Daines, WJ Morgan, and EM Snyder. Influence of an Inhaled B-agonist on Alveolar-Capillary Membrane Conductance and Oxygen Saturation in Patients with Cystic Fibrosis. Am J Respir Crit Care Med 181;2010: A1827 42. *CM Wheatley, NA Cassuto, WT Foxx-Lupo, H Phan, O Molina, CL Daines, WJ Morgan, EM Snyder. Influence of an Inhaled β-Agonist on Exhaled Na+, K+,

and Cl- in Patients with Cystic Fibrosis. Am J Respir Crit Care Med 181;2010: A1839. 43. *WT Foxx-Lupo, BR Traylor, NA Cassuto, CM Wheatley, EC Wong, CL Daines, WJ Morgan, EM Snyder. Red Blood Cell Transit Time is Lower During

Exercise in Patients with Cystic Fibrosis Compared to Healthy Subjects. Am J Respir Crit Care Med 181;2010: A5326. 44. *WT Foxx-Lupo, CM Wheatley, NA Cassuto, EC Wong, AE Patanwala, NA Delamere, and EM Snyder. Genetic Variation of the Alpha Subunit of the Epithelial Na+ Channel Influences Exhaled Na+ in Response to Albuterol in Humans. FASEB J. 2010 24:1021.5. 45. *EC Wong, CM Wheatley, NA Cassuto, WT Foxx-Lupo, AE Patanwala, and EM Snyder. Cardiovascular Effects of a Nebulized B-agonist Compared to

Saline in Healthy Humans. FASEB J. 2010 24:596.7. 46. *CM Wheatley, NA Cassuto, WT Foxx-Lupo, EC Wong, AE Patanwala, and EM Snyder. Comparison of Ion Regulation of Airway Surface Liquid and Urine in

Healthy Humans. FASEB J. 2010 24:611.26. 47. *NA Cassuto, EC Wong, JC Baldi, CM Wheatley, WT Foxx-Lupo, and EM Snyder. Muscular Efficiency in Trained Type 1 Diabetic Patients. FASEB J. 2010

24:806.23. 48. *CM Wheatley, NA Cassuto, WT Foxx-Lupo, EC Wong, NA Delamere, and EM Snyder. Relationship Between Exhaled Na+ and the Diffusion Capacity of the

Lungs for Carbon Monoxide (DLCO) and Alveolar-Capillary Membrane Conductance in Healthy Humans. FASEB J. 2010 24:1063.3. 49. *CM Wheatley, NA Cassuto, WT Foxx-Lupo, EC Wong, T Skrentny, B Traylor and EM Snyder. Influence of Albuterol on Cardiac Output and Blood Pressure in Healthy Individuals. 2009. AHSC Frontiers in Biomedical Research Poster Forum, Tucson, AZ. 50. *B Traylor, WT Foxx-Lupo, CM Wheatley, NA Cassuto, and EM Snyder. Albuterol Improves Lung Diffusion and Oxygen Saturation Patients with Cystic Fibrosis. American Society of Health-System Pharmacists 44th Annual Midyear Clinical Meeting. Las Vegas, NV. 2009. 51. *NA Cassuto, CM Wheatley, WT Foxx-Lupo, A Patanwala, H Phan, O Molina, CL Daines, WJ Morgan, EM Snyder. Influence of an Inhaled B-Agonist on Exhaled Na+, K+, and Cl- in Humans. North American Cystic Fibrosis Foundation Annual Meeting, Minneapolis, MN. 2009. 52. *NA Cassuto, CM Wheatley, WT Foxx-Lupo, A Patanwala, H Phan, O Molina, CL Daines, WJ Morgan, EM Snyder. Alveolar-Capillary Membrane Conductance

and Pulmonary Capillary Blood Volume During Exercise in Patients with Cystic Fibrosis. North American Cystic Fibrosis Foundation Annual Meeting, Minneapolis, MN. 2009.

53. *NA Cassuto, CM Wheatley, WT Foxx-Lupo, JC Baldi, and EM Snyder. Impaired Lung Membrane Diffusion Reduces Oxygen Saturation in Exercise-Trained Patients with Type-I Diabetics. American College of Chest Physicians. San Diego, CA. 2009. 54. *NA Cassuto, CM Wheatley, WT Foxx-Lupo, Allison R. Denney, Brittany D. Stokes, JC Baldi, and EM Snyder. Cardiovascular and Pulmonary Response to Exercise in Trained Type-I Diabetics; Influence of Glycemic Control. American Diabetes Association Annual Meeting. New Orleans, LA.2009 55. *NA Cassuto, C Wheatley, WT Foxx-Lupo, JC Baldi, and EM Snyder. Glycemic Control and Alveolar-Capillary Membrane Conductance at Rest and During Exercise in Trained Type-I Diabetic Patients. American Diabetes Association Annual Meeting 2009. New Orleans, LA. 56. *NA Cassuto, C Wheatley, WT Foxx-Lupo, and EM Snyder. Variability in

measures of exhaled breath Na+ and K+, influence of cardiac output and saliva. Experimental Biology 2009. New Orleans, LA. 57. BD Johnson, JC Baldi, ML Hulsebus, M Johnson and EM Snyder. Hypoxia

Induced Changes in Lung Fluid Balance in Humans is Associated with Beta-2 Adrenergic Receptor Density on Lymphocytes. Annual International hypoxia Symposium. Lake Louise, Canada. 2009. 58. EM Snyder, ML Ceridon, ML Hulsebus, and BD Johnson. Influence of Albuterol on Alveolar-Capillary Membrane Conductance in Patients with Heart Failure. American College of Clinical Pharmacy 2008 Annual Meeting, Louisville, KY. 59. *NA Cassuto, S Lalande, TP Olson, BD Johnson, and EM Snyder. The

Arg16Gly Polymorphism of the Beta-2 Adrenergic Receptor and Muscular Efficiency During Exercise. Integrative Biology of Exercise, Hilton Head South Carolina. 60. *NA Cassuto, EM Snyder, S Lalande, TP Olson, and BD Johnson. Gender Differences in Muscle Efficiency During Short-Term Exercise. Integrative Biology of Exercise, Hilton Head South Carolina. 61. Dutoit A, Snyder EM, Hulsebus ML, Johnson BD, Eisenach JH. Echocardiographic outcomes according to Beta-2 adrenergic receptor haplotypes in patients with heart failure. Midwest Anesthesia Research Conference, Indianapolis, IN, 2008. 62. Eisenach JH, Snyder EM, Hulsebus ML, Turner ST, Johnson BD. Beta-2

Adrenergic Receptor Haplotype and Echocardiographic Indices in Heart Failure Patients. Experimental Biology, 2008.

63. EM Snyder, TP Olson, M Orban, ML Hulsebus, VK Somers, BD Johnson,

and RP Frantz. Influence of Sildenafil or Acetazolamide on Pulmonary Gas Transfer with 17-hours of Hypoxic Exposure in Healthy Humans. American thoracic Society Annual Meeting, 2008. 64. ML Ceridon, EM Snyder, TP Olson, ML Hulsebus, and BD Johnson. Influence of acute graded hypoxia on the bronchial circulation in healthy humans. Experimental Biology, 2008. 65. ML Ceridon, EM Snyder, NA Strom, JT Schirren, and BD Johnson. Influence of rapid fluid loading on airway structure and function in healthy humans. Experimental Biology, 2008. 66. EM Snyder, TP Olson, Y Ji, ST Turner, RM Weinshilboum, and BD Johnson. Haplotype Combinations of the Gene that Encodes the Beta-2 Adrenergic Receptor and Pulmonary Function in Patients with Heart Failure. American Thoracic Society Annual Meeting, 2008. 67. EM Snyder, Y Ji, MJ Joyner, ST Turner, RM Weinshilboum and BD Johnson.

Interaction Gene-by-Gene interactions of Phenylethanolamine-N-methyltransferase and the Beta-2 Adrenergic Receptor and the Ventricular Response to Exercise. Experimental Biology, 2008. 68. S Lalande, EM Snyder, TP Olson, M Orban, V Somers, BD Johnson, RP Frantz. The effects of sildenafil and acetazolamide on ventilatory efficiency during hypoxic exercise. Experimental Biology, 2008. 69. S Lalande, EM. Snyder, TP Olson, M Orban, V Somers, BD Johnson, and RP Frantz. The effect of sildenafil and acetazolamide on sleep architecture with hypoxia. American Thoracic Society Annual Meeting, 2008. 70. LJ Olson, EM Snyder, JM Miller, CG Scott, and BD Johnson. Increased Circulating Norepinephrine is Associated with Disordered Ventilatory Control in Heart Failure. Mayo Clinic Center for Translational Science Activities Research Fair. August 2007. 71. EM. Snyder, ML Hulsebus, KA O’Malley, and BD Johnson. β2 Adrenergic

Receptor Genotypes and Lung Fluid Balance In Healthy Humans. Mayo Clinic Center for Translational Science Activities Research Fair. August 2007. 72. EM. Snyder, ML Hulsebus, KA O’Malley, and BD Johnson. Hypoxic Exposure Reduces Lung Water in Healthy Humans. Mayo Clinic Center for Translational Science Activities Research Fair. August 2007.

73. LJ Olson, Eric M. Snyder, JM Miller, CG Scott, and BD Johnson. Increased Circulating Norepinephrine Concentration is Associated with Disordered Ventilatory Control in Heart Failure. American College of Cardiology, 2008. 74. LJ Olson, EM Snyder, JM Miller, BD Johnson, and VK Somers. Enhanced Chemosensitivity to Carbon Dioxide in Patients with Heart Failure and Central Sleep Apnea. Heart Failure Society of America Annual Meeting, 2007. 75. J Kjaergaard, EM Snyder, C Hassager, TP Olson, JK Oh, BD Johnson, and RP Frantz. Right ventricular function with hypoxic exercise: effects of Sildenafil. American Heart Association Scientific Sessions, 2007. 76. J Kjaergaard, EM Snyder, C Hassager, TP Olson, JK Oh, BD Johnson, and RP Frantz. The effect of Sildenafil on right ventricular function in hypoxic exercise. European Echocardiography Society, 2007. 77. JH Eisenach, TL Pike, EM Snyder, ST Turner, BD Johnson, MJ Joyner. High-resolution phenotyping the Arg16/Gly β2-adrenergic receptor polymorphism in humans: where are we now? Association of University Anesthesiologists Annual Meeting, 2007. 78. EM Snyder and BD Johnson. Albuterol improves alveolar-capillary

membrane conductance in healthy humans. Experimental Biology. Washington, DC, 2007. 79. EM Snyder, RP Frantz, TP Olson, KA O’Malley, and BD Johnson. Sildenafil

improves alveolar-capillary conductance following hypoxic exercise in healthy humans. International Hypoxia Symposium. Alberta, Canada, 2007. 80. WG Schrage, EM Snyder, and BD Johnson. Systemic hemodynamic

responses to 18-hours of continuous hypoxia in healthy adults. International Hypoxia Symposium. Alberta, Canada, 2007. 81. B Fridley, Y Ji, EM Snyder, T Batzler, G Jenkins, D Schaid, and R

Weinshilboum. Repeated measures haplotype analysis. Pharmacogenomic Research Network Workshop, 2006. 82. M Dalsgaard, EM Snyder, J Kjaergaard, JK Oh, C Hassager, and BD

Johnson. Isovolumic acceleration measured by tissue Doppler echocardiography is preload independent in healthy subjects. EuroEcho 10th annual meeting. Prague, Czech Republic, 2006. 83. TP Olson, EM Snyder, RP Frantz, ML Hulsebus, KA O’Malley, KR Bailey, CM Wood, LJ Olson, ST Turner, and BD Johnson. Gene Variant of the Bradykinin B2 Receptor Influences Pulmonary Arterial Pressures in Heart Failure Patients. Heart Failure Society of America, 10th Annual Meeting, Seattle, WA.

84. J Kjaergaard, EM Snyder, C Hassager, J Oh, and BD Johnson. Quantitative

Echocardiographic Assessment of Right Ventricular Response to Simulated High Altitude in Healthy Subjects. Pulmonary Circulation Congress, European Forum. Warsaw, Poland, 2006. 85. J Kjaergaard, EM Snyder, C Hassager, TP Olson, Jae K. OH MD, and BD Johnson. Effects of High Altitude on Global and Regional Left Ventricular Performance and Filling Pressure. Journal of the American Society of Echocardiography. 19(5). 2006. 86. JH Eisenach, DR Schroeder, TL Pike, CP Johnson, WG Schrage, EM Snyder, BD Johnson, ST Turner, and MJ Joyner. Cardiovascular Modulation of Dietary Sodium restriction and Beta-2 Adrenergic Receptor Polymorphism in Humans. Journal of Investigative Medicine. 54: S375, 2006. 87. TP Olson, EM Snyder, RP Frantz, ST Turner, and BD Johnson. Repeat Length Polymorphism of the Serotonin Transporter Gene Influences Pulmonary Artery Pressure in Heart Failure. The FASEB Journal. 20(4). 2006. 88. JH Eisenach, DR Schroeder, TL Pike, EM Snyder, BD Johnson, ST Turner, and MJ Joyner. Forearm blood flow and Arg16/Gly β2-adrenergic receptor polymorphism following dietary sodium restriction. The FASEB Journal. 20(4). 2006. 89. EM Snyder, ST Turner, JH Eisenach, MJ Joyner, and BD Johnson. The

Arg16Gly polymorphism of the beta-2 adrenergic receptor is associated with differences in the natriuretic response to rapid saline infusion. The FASEB Journal. 20(4). 2006. 90. EM Snyder, RD Carr, CF Deacon, and BD Johnson. Influence of hypoxia on plasma glucagon-like peptide-1 and leptin levels in healthy humans. The FASEB Journal. 20(4). 2006. 91. EM Snyder, TP Olson, KA O’Malley, ML Hulsebus, and BD Johnson. Breathing Strategy and Ventilatory Control During Sleep in Normobaric Hypoxia. Proceedings of the American Thoracic Soc. 2006;3:A719. 92. Y Ji, OE Salavaggione, EM Snyder, BD Johnson, and R Weinshilboum. Human Phenylethanolamine N-Methyltransferase (PNMT) Functional Genomics. Drug Metabolism Reviews. 37(121). 2005. 93. NR Morris, KC Beck, EM Snyder, TP Olson, LJ Olson, and BD Johnson. Resting Circulation time as a Predictor of Exercise Capacity in Chronic Heart Failure Patients. Journal of Cardiac Failure. 11(6). 2005

94. EM Snyder, RP Frantz, and BD Johnson. Influence of Hypoxia on Exhaled Nitric Oxide, Pulmonary Function, and Right Ventricular Systolic Pressures in Healthy Humans. High Altitude Medicine and Biology. 5(4) #82. Winter, 2004. 95. EM Snyder, KC Beck , JF Breen, EA Hoffman, and BD Johnson. Influence of Hypoxia and Hypoxic Exercise on Lung Water, Pulmonary Capillary Blood Volume, Alveolar-Capillary Conductance, and Lung Water. High Altitude Medicine and Biology. 5(4) #81. Winter, 2004.*Selected as one of the top ten student/fellow abstracts 96. EM Snyder, ML LaPolice, AR Penheiter, ST Turner, MJ Joyner, and BD Johnson. Influence of the Arg16Gly Polymorphism of the Beta-2 Adrenergic Receptor on Lymphocyte Receptor Density. The FASEB Journal. 19(4). 2005. 97. EM Snyder, KC Beck, MJ Joyner, ST Turner, and BD Johnson. Influence of Genotype Variation of the Beta-2 Adrenergic Receptor on Lung Fluid Balance in Healthy Humans. The FASEB Journal. 19(4). 2005. 98. J Sierra-Johnson, EM Snyder, KA O’Malley, AJ Tarara, and BD Johnson. Sex Differences in the Relationship Between Leptin and Lung Function in Healthy Adults. Proceedings of the American Thoracic Society. 2(1) 527. 2005. 99. EM Snyder, LJ Olson, AJ Tarara, ST Turner, and BD Johnson. Influence of Beta-2 Adrenergic Receptor Genotype on Pulmonary Function in Heart Failure Patients. Proceedings of the American Thoracic Society. 2(1) 527. 2005. 100. EM Snyder, KC Beck, and BD Johnson. Influence of hypoxia at rest and during exercise on pulmonary capillary blood volume and alveolar-capillary conductance. The Physiologist. Vol 27(4). August, 2004. 101. JH Eisenach, ST Turner, EM Snyder, NM Dietz, and MJ Joyner. Pleiotropic Phenotypic Effects of the Arg16/Gly β2-Adrenergic Receptor Polymorphism in Blood Pressure Regulation. Anesthesiology Journal. 101. A-242. 2004. 102. LJ Olson, VK Somers, EM Snyder, AM Arruda-Olson, T Kyra, J Nykodym, and BD Johnson. Enhanced ventilatory and heart rate response to central chemoreflex activation in patients with heart failure and central sleep apnea. Journal of Cardiac Failure, 10(4) Supplement 1. 2004. 103. NR Morris, EM Snyder, A Arruda-Olson, KC Beck, LJ Haseler, DA

Schneider, and BD Johnson. Use of an inhaled acetylene method to estimate changes in lung to lung circulation time during exercise in heart failure patients. Journal of Cardiac Failure, 10(4) Supplement 1. 2004.

104. NR Morris, KA O’Malley, KC Beck, LJ Haseler, EM Snyder, and BD Johnson. Total circulation time in heart failure patients measured using acetylene technique. Journal of Molecular and Cellular Cardiology. 37. 217-218. 2004. 105. EM Snyder, MJ Joyner, NM Dietz, JH Eisenach, KC Beck, ST Turner, and BD Johnson. Influence of Beta-2 Adrenergic Receptor (B2AR) Genotype on Cardiovascular Function during Exercise in Healthy Humans. The FASEB Journal. 18(4). p.A750. March 23, 2004. 106. EM Snyder, KC Beck, MJ Joyner, NN Dietz, ST Turner KA O’Malley, AJ

Tarara and BD Johnson. Influence of Beta 2 Adrenergic Receptor Genotype on Gas Exchange During Exercise in Healthy Adults. American Journal of Respiratory and Critical Care Medicine. 169(7), supplement. 2004. 107. EM Snyder, KC Beck, MJ Joyner, NN Dietz, ST Turner, and BD Johnson. Beta-2 Adrenergic Receptor Genotype and Airway Function During and After Exercise in Healthy Humans. American Journal of Respiratory and Critical Care Medicine. 169(7), 2004.*Highlighted Abstract 108. KC Beck, EM Snyder, KA O’Malley, and BD Johnson. DLCO by open

circuit wash-in during exercise: comparison to rebreathe method. American Journal of Respiratory and Critical Care Medicine. 167(7), A420. 2003. TEACHING AND CURRICULUM DEVELOPMENT

Curriculum/Course Development

Individualized Medicine, Pharmacogenetics for Pharmacy Students. Developed 2008, Instruction Spring 2009-2012, University of Arizona. 3-credits. KIN 5122: Applied Exercise Physiology. University of Minnesota. Developed 2012, Instruction 2012-present. KIN 5720: Cardiopulmonary Exercise Physiology. University of Minnesota, Developed 2013-2014, Instruction 2014-present. Teaching Activities, Didactic Personal and Community Health (HERS 204) Winona State University. 2002-2010. Alterations in Lung Fluid Balance with Exposure to Hypoxia and in Patients with Heart Failure. Winona State University. February 9th, 2006.

Assessment of Lung Fluid Balance in Humans. Course: Human Studies Methodologies. Department of Physiology and Biomedical Engineering. Mayo Clinic Graduate School of Medicine. June 28th, 2005. Individualized Medicine, Pharmacogenetics for Pharmacy Students. Developed 2008, Instruction Spring 2009, University of Arizona. 3-credits. KIN 5122: Applied Exercise Physiology. University of Minnesota. 3-credits. KIN 5720: Cardiopulmonary Exercise Physiology. University of Minnesota, Developed 2013-2014. 3-credits. Kin 3982: Research Methods in Kinesiology. Fall 2014. 3-credits. STUDENTS MENTORED

Undergraduate Students Nicholas A. Strom 2006-2007

Summer Intern, Mayo Clinic Pre-medical student, University of North Dakota. Research Project: “Development of a technique to Quantify Bronchial Blood Flow in Humans” Currently pursuing MBA

Graduate Students Sophie, Lalande, PhD 2007

Graduate Student, pre-doctoral Fellow Division of Cardiovascular Diseases Mayo Clinic Graduate School of Medicine Research Project “Influence of Acetazolamide on Pulmonary Dynamics with Exposure to Hypoxia in Humans” Currently a Post-Doctoral Fellow in London, England

Maile Ceridon, PhD 2006-2010 Graduate Student, Pre-Doctoral Fellow, PhD candidate Division of Physiology and Biomedical Engineering Mayo Clinic Graduate School of Medicine

Research Project One “Influence of graded hypoxia on bronchial blood flow in humans”

Research Project Two “Influence of Rapid Fluid Loading on Airway Structure and Function in Humans” Currently a Scientist with the United States Air Force

Courtney Wheatley, PhD 2008-2013

Clinical Research College of Pharmacy University of Arizona AWARDS/GRANTS While Under My Mentorship:

1. PEO Scholarship 2. Caldwell Grant 3. University of Arizona Graduate and Professional Student Council

Travel Grant 4. American College of Sports Medicine

Currently a Post-Doctoral Fellow at the Mayo Clinic in Rochester, Minnesota

Sarah Baker, PhD 2010-2013 Physiological Sciences University of Arizona

Currently a Post-Doctoral Fellow at the Mayo Clinic in Rochester, Minnesota

Marina Martinez, PhD 2010-2014

Physiological Sciences University of Arizona

Currently Post-Doctoral Fellow at the University of Arizona in Tucson, Arizona

Benjamin Peterson, PhD 2012-2014 Kinesiology University of Minnesota Sports Performance Manager, Catapult Sports Patrick Wilson, PhD 2012-2014 Kinesiology University of Minnesota Currently a Post-Doctoral Fellow at University of Nebraska

Alex Kasak 2nd year PhD student 2013-present

University of Minnesota, Department of Kinesiology Alex Bisch 2013-present 2nd year MS student University of Minnesota, Department of Kinesiology Emma Lee 2013-present 2nd year PhD student University of Minnesota, Department of Kinesiology Erik Vaniterson 2013-present 4th year PhD student University of Minnesota, Department of Kinesiology Kate Nyberg 2014-present 1st year PhD student University of Minnesota, Department of Kinesiology Eli Kelly 2014-present 1st year PhD student University of Minnesota, Department of Kinesiology Christopher Lundstrom 2012-present 4th year PhD Student University of Minnesota, Department of Kinesiology Co-mentor: Stacy Ingraham Gregory Rhodes 2012-present

4th year PhD Student University of Minnesota, Department of Kinesiology Co-mentor: Stacy Ingraham Graduate Committees of Students for Whom I am not Primary Mentor: Joe Ostrem, MS

PhD Student, mentor: Dr. Don Dengel Professional Students William Travis Foxx-Lupo, PharmD 2009-2012 Pharmacy Resident University of Washington

Nicholas A. Cassuto, MD 2008-2012 Medical Resident Tucson Medical Center Britany R. Traylor, PharmD 2009-2010 Pharmacist, UC Davis AWARDS/GRANTS While Under My Mentorship: American Society of health-System Pharmacists Research and Education Student Research Award $2500 honorarium and expense allowance Eric C. Wong, PharmD 2009-2013 Pharmacy Resident, University of Washington University of Arizona AWARDS/GRANTS While Under My Mentorship: College of Pharmacy Research Caldwell Award, $2500 Ryan Pett, PharmD 2009-2012

Pharmacy Resident Centers for Disease Control Sarah Lau 2011-2012

4th year Medical Student University of Arizona Stephen Karpen, PharmD 2009-2013

Fellow, Arizona Poison Control Center SERVICE AND PUBLIC OUTREACH

Service to the Discipline/Profession/Interdisciplinary Area(s)

Editorial Board Member 2012-present Medicine and Science in Sports and Exercise 2012-present Dataset Papers in Genetics

Reviewer: -Appetite -Pharmacogenetics and Genomics -Current Pharmacogenomics -Clinical Pharmacology and Therapeutics -Journal of Physiology, London -Physiological Genomics -The Journal of Applied Physiology

-American Journal of Physiology-Heart and Circulatory Physiology -American Heart Journal -Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine -Journal of Human Genetics -Medicine and Science in Sports and Exercise -Respiratory Physiology and Neurobiology -European Journal of Applied Physiology -Journal of Cardiac Failure -American Journal of Cardiology -Physiological Research -Experimental Physiology -Pediatric Pulmonology -Journal of Cystic Fibrosis -Neuroscience Letters -Aviation, Space, and Environmental Medicine -Applied Physiology Nutrition and Metabolism -Open Sports Medicine Journal -Diabetalogia

Member: Communications Committee 2011-present American Physiological Society

Service to the University/College/Department

Member: Undergraduate Program Committee Department of Kinesiology University of Minnesota Member: M.Ed. Program Committee Department of Kinesiology University of Minnesota Member: Blue Ribbon Committee Department of Kinesiology University of Minnesota Member: Search Committee Physical Therapy Faculty Search Department of Physical Therapy and Rehabilitation Sciences University of Minnesota Reviewer: CEHD Faculty/Staff Research Grants College of Education and Human Development University of Minnesota Faculty Member: Graduate Interdisciplinary Program For Physiological Sciences

University of Arizona Member: Progress Committee, Graduate Interdisciplinary Program For Physiological Sciences University of Arizona Member: Research Affairs Committee, University of Arizona College of Pharmacy Member: Hiring Committee, Translational Scientist Positions, University of Arizona College of Pharmacy Member: Building Transformation Grant Committee: Application for Stimulus Funds University of Arizona College of Pharmacy Member: Young Investigators Training Group University of Arizona College of Pharmacy Member: Admission Committee University of Arizona College of Pharmacy Member: Professionalism Committee University of Arizona College of Pharmacy