curriculum vitae merrill, alfred h., jr. professor and ... · 2/24/2014 · curriculum vitae...

2-24-2014 CURRICULUM VITAE

MERRILL, ALFRED H., JR. Professor and Smithgall Chair in Molecular Cell Biology School of Biology and Petit Institute for Bioengineering & Bioscience Georgia Institute of Technology Atlanta, GA 30332-0230 Personal Data: Born: July 30, 1951, Roanoke, Virginia Educational Background: B.S. Biochemistry & Nutrition 1974 Virginia Polytechnic Inst. & State Univ., Blacksburg, VA Ph.D. Biochemistry, Molecular & 1979 Cornell University Cell Biology Ithaca, NY (w/Donald B. McCormick) Certificate Underground Storage Tank 2012 Georgia Institute of Technology Class C Operator Training Atlanta, GA Employment History: NIH Predoctoral Trainee, Cornell University 1977-1979 NIH Postdoctoral Trainee, Duke University (w/Bob Bell) 1979-1980 Assistant Professor, Dept. Biochemistry, Emory Univ. Sch. Med. 1981-1987 Associate Professor, Dept. Biochemistry, Emory Univ. Sch. Med. 1987-1992 [Visiting Scientist, University of Alberta, Canada, Dennis Vance, Summer, 1989] [Visiting Scientist, Univerity of Bonn, Germany, Konrad Sandhoff, Summer, 1992] Professor, Dept. Biochemistry, Emory Univ. Sch. Med. 1992-2001 [Director, Graduate Program in Nutrition & Health Sciences, Division of Biological & Biomedical Sciences, Emory 1991-97] [Director, Emory Center for Nutrition & Health Sciences, 1992-2000] Professor and Smithgall Chair in Molecular Cell Biology, School of Biology, Georgia Institute of Technology 2001-present Member, Petit Institute for Bioengineering and Bioscience 2001-present Adjunct Professor, Sch. of Chem. & Biochem., GA Tech 2003-present Current Fields of Interest: Sphingolipid metabolism and cell regulation Lipidomics and metabolomics (systems biology) Biomolecular mass spectrometry & imaging Sphingolipids and disease (especially cancer)

Alfred H. Merrill, Jr., Ph.D.

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Teaching Experience: Quarter, year Course number Course title # of students Fall, 2013 BIOL3450 Cell & Molecular Biology 115 Fall, 2013 BIOL4015/7015 Cancer biology & technology 135 Spring, 2013 BIOL3450 Cell & Molecular Biology 119 Fall, 2012 BIOL3450 Cell & Molecular Biology 139 Fall, 2012 BIOL4015/7015 Cancer biology & technology 115 Spring, 2012 BIOL3450 Cell & Molecular Biology 110 Fall, 2011 BIOL3450 Cell & Molecular biology 116 Fall, 2011 BIOL4015/7015 Cancer biology & technology 86 Spring, 2011 BIOL3340 Cell biology 108 Fall, 2010 BIOL3340 Cell biology 122 Fall, 2010 BIOL4015/7015 Cancer biology & technology 79 Spring, 2010 BIOL3340 Cell biology 80 Fall, 2009 BIOL3340/7010 Cell Biology 134 Fall, 2009 BIOL4015/8802 Cancer biology & technology 79 Spring, 2009 BIOL3340 Cell biology 84 Fall, 2008 BIOL3340 Cell biology 122 Fall, 2008 BIOL4015,8802 Cancer biology & biotechnology 80 Spring, 2008 BIOL3340 Cell biology ~90 Fall, 2007 BIOL3340 Cell biology 109 Fall, 2007 BIOL4802,8802 Cancer biology & biotechnology 90 Spring, 2007 BIOL3340 Cell biology 79 Fall, 2006 BIOL3340 Cell biology 88 Fall, 2006 BIOL4802/8802 Cancer biology & biotechnology 64 Spring, 2006 BIOL3340 Cell biology 61 Fall, 2005 BIOL3340 Cell biology 90 Fall, 2005 BIOL4802/8802 Cancer biology & biotechnology 52 Spring, 2005 BIOL3340 Cell biology 40 Fall, 2004 BIOL3340 Cell biology 50 Fall, 2004 BIOL4802/8802 Cancer biology & biotechnology 55 Spring, 2004 BIOL3340 Cell biology 47 Fall, 2003 BIOL3340 Cell biology 32 Fall, 2003 BIOL4802/8802 Cancer biology & biotechnology 54 Spring, 2003 BIOL3340 Cell biology 85 Fall, 2002 BIOL1520 Intro. Biology 135 Fall, 2002 BIOL3331 Cell biology 40 Fall, 2002 BIOL4802/8802 Cancer biology & biotechnology 38 Spring, 2002 BIOL3331 Cell biology 84 Approximately half of the lectures in Cell biology have been shared with another faculty member each semester (in recent years, Drs. Yuhong Fan, Chong Shin and Fred Vannberg); in addition, Dr. Merrill has participated in part of the labs (BIOL3341) associated with this course. Not listed above are undergraduate research, MS and doctoral thesis supervision, etc. Dr. Merrill is also a guest lecturer for the graduate course in nutrition at Emory University.


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Major courses taught at Emory prior to coming to Georgia Tech IBS 521: Biochemistry (course director and lecturer) IBS 580 and 581: Human Nutrition I & II (course director) MEDI 635: Medical Nutrition (lecturer; course co-director) Biochemistry 730r: Medical Biochemistry (lecturer) Molecular Mechanisms of Signal Transduction (lecturer). Refereed Publications: 1. Merrill AH Jr & Campbell TC (1974) Preliminary study of in vitro aflatoxin B1 metabolism

by human liver. Toxicol Appl Pharm 27: 210-213 2. Hayes JR, Mgbodile MUK, Merrill AH Jr, Nerurkar LS & Campbell TC (1978) The effect

of dietary protein depletion and repletion on rat hepatic mixed function oxidase activities. J Nutr 108: 1788-1797

3. Pimental D, Krummel J, Gallahan D, Hough J, Merrill AH Jr, Schreiner I, Vittum P, Koziol F, Back E, Yen D & Fiance S (1978) Benefits and costs of pesticide use in U.S. food production. Bioscience 28: 722, and 778-784

4. Merrill AH Jr & McCormick DB (1978) Flavin affinity chromatography: General methods for purification of proteins that bind riboflavin. Anal Biochem 89: 87-102

5. Merrill AH Jr, Addison R & McCormick DB (1978) Induction of hepatic and intestinal flavokinase after oral administration of riboflavin to riboflavin-deficient rats. Proc Soc Exp Biol Med 158: 572-574

6. Merrill AH Jr, Horiike K & McCormick DB (1978) Evidence for the regulation of pyridoxal 5’-phosphate formation in liver by pyridoxamine (pyridoxine) 5’-phosphate oxidase. Biochem Biophys Res Commun 83: 984-990

7. Pimental D, Krummel J, Gallahan D, Hough J, Merrill AH Jr, Schreiner I, Vittum P, Koziol F, Back E, Yen D & Fiance S (1979) Benefits and costs of pesticide use in U.S. food production. In: Pesticides: Role in Agriculture, Health, and Environment (Sheets TJ & Pimental D eds) Humana Press, Clifton, NJ, pp. 97-149

8. Horiike K, Merrill AH Jr & McCormick DB (1979) Activation and inactivation of rabbit liver pyridoxamine (pyridoxine) 5’-phosphate oxidase activity by urea and other solutes. Arch Biochem Biophys 195: 325-335

9. Merrill AH Jr & McCormick DB (1979) Preparation and properties of immobilized flavokinase. Biotech Bioeng 21: 243-252

10. Merrill AH Jr, Kasai S, Matsui K, Tsuge H & McCormick DB (1979) Spectroscopic studies of pyridoxamine (pyridoxine) 5’-phosphate oxidase. Biochemistry 18: 3635-3641

11. Merrill AH Jr, Froehlich JA & McCormick DB (1979) Affinity chromatographic purification of riboflavin-binding proteins from bovine plasma and discovery of a pregnancy-specific riboflavin-binding protein. J Biol Chem 254: 9362-9364

12. Froehlich JA, Merrill AH Jr, Clagett CO & McCormick DB (1980) Affinity chromatography purification and comparison of riboflavin-binding proteins from laying hen liver and blood from egg yolk. Comp Biochem Physiol 66B: 397-401

13. Merrill AH Jr & McCormick DB (1980) Affinity chromatographic purification and properties of flavokinase (ATP: riboflavin 5’-phosphotransferase) from rat liver. J Biol Chem 225: 1335-1338


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14. Merrill AH Jr, Korytnyk W, Horiike K & McCormick DB (1980) Spectroscopic studies of complexes between pyridoxamine (pyridoxine) 5’-phosphate oxidase and pyridoxyl 5’-phosphate compounds differing at position 4’. Biochim Biophys Acta 626: 57-63

15. Merrill AH Jr, Froehlich JA & McCormick DB (1981) Isolation and identification of alternative riboflavin-binding proteins from human plasma. Biochem Med 25: 198-206

16. Green P, Merrill AH Jr & Bell RM (1981) Membrane phospholipid synthesis in Escherichia coli: Purification, reconstitution, and characterization of homogeneous sn-glycerol 3-phosphate acyltransferase. J Biol Chem 256: 11151-11159

17. Merrill AH Jr, Shapira G & McCormick DB (1982) Recent findings concerning mammalian riboflavin-binding proteins. In: Flavins and Flavo-proteins: Proc. of the 7th Internat. Symposium of Flavins and Flavoproteins (Massey V & Williams CH eds) Elsevier, North Holland Press, Amsterdam, 508-513

18. Merrill AH Jr, Gidwitz S & Bell RM (1982) Facile enzymatic syntheses of fatty acyl-coenzyme A thioesters. J Lipid Res 23, 1368-1373

19. Merrill AH Jr (1983) Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells. Biochim Biophys Acta 754: 284-291

20. Williams RD, Wang E & Merrill AH Jr (1984) Enzymology of long-chain base synthesis by rat liver. Characterization of serine palmitoyltransferase of rat liver microsomes. Arch Biochem Biophys 228: 282-291

21. Merrill AH Jr & Williams RD (1984) Utilization of different fatty acyl-CoA thioesters by serine palmitoyl transferase from rat brain. J Lipid Res 25: 185-188

22. Williams RD, Nixon DW & Merrill AH Jr (1984) Comparison of serine palmitoyltransferase in Morris hepatoma 7777 and rat liver. Cancer Res 44: 1918-1923

23. Merrill AH Jr, Wang E, Stevens J & Brumley GW (1984) Activities of the initial enzymes of glycerolipid and sphingolipid synthesis in lung microsomes from rats exposed to air or 85% oxygen. Biochem Biophys Res Commun 119: 995-1000

24. Merrill AH Jr, Henderson JM, Wang E, McDonald BW & Millikan WJ (1984) Metabolism of vitamin B6 by human liver. J Nutr 114: 1664-1674

25. Merrill AH Jr, Nixon DW & Williams RD (1985) Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues. J Lipid Res 26: 617-622

26. Merrill AH Jr, Wang E, Innis WSA & Mullins RE (1985) Increases in serum sphingomyelin by 1-ß-estradiol. Lipids 20: 252-254

27. Innis WSA, McCormick DB & Merrill AH Jr (1985) Variation in riboflavin binding by human plasma proteins: Identification of IgGs as the major proteins responsible. Biochem Med 34: 151-165

28. Merrill AH Jr, Wang E & Hargrove JL (1985) Hepatic enzymes of sphingolipid and glycerolipid biosynthesis in rats from Spacelab 3. The Physiologist 28: S229

29. Innis WSA, Nixon DW, Murray DR, McCormick DB & Merrill AH Jr (1986) Elevated riboflavin binding by plasma proteins from patients with certain types of cancer. Proc Soc Exp Biol Med 181: 237-241

30. Henderson JM, Codner MA, Hollins B, Kutner MH & Merrill AH Jr (1986) The fasting B6 vitamin profile and response to a pyridoxine load in normal and cirrhotic subjects. Hepatology 6: 464-471

31. Merrill AH Jr & Wang E (1986) Biosynthesis of long-chain (sphingoid) bases from serine by LM-cells. Evidence for introduction of the 4-trans-double bond after de novo


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biosynthesis of N-acylsphinganine(s). J Biol Chem 261: 3764-3769 32. Merrill AH Jr, Henderson JM, Wang E, Codner MA, Hollins B & Millikan WJ (1986)

Activities of the hepatic enzymes of vitamin B6 metabolism for patients with cirrhosis. Am J Clin Nutr 44: 461-467

33. Stevens VL, Lambeth JD & Merrill AH Jr (1986) Use of cytochrome P-450scc to measure cholesterol-lipid interactions. Biochemistry 25: 4287-4292

34. Merrill AH Jr, Wang E & Wertz PW (1986) Differences in the long-chain composition of sphingomyelin from Morris hepatoma 7777 and host and control livers. Lipids 21: 529-530

35. Merrill AH Jr, Wang E, Jones DP & Hargrove JL (1986) Hepatic function in rats after spaceflight: Effects on lipids, glycogen and enzymes of lipid, amino acid, and xenobiotic metabolism. Am J Physiol 252: R222-R22

36. Merrill AH Jr, Wang E, Yanish M & Nixon DW (1986) Responses by 3T3-L1 cells to lipogenic and lipolytic factors in human plasma. Nutr Res 6: 923-929

37. Hannun YA, Loomis CR, Merrill AH Jr & Bell RM (1986) Mechanism of sphingosine inhibition of protein kinase C activity and of phorbol-dibutyrate binding. J Biol Chem 261: 12604-12609

38. Merrill AH Jr, Sereni AM, Stevens VL, Hannun YA, Bell RM & Kinkade JM Jr. (1986) Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem 261: 12610-12615

39. Wilson E, Olcott MC, Bell RM, Merrill AH Jr. & Lambeth JD (1986) Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases: Role of protein kinase C in activation of the burst. J Biol Chem 261: 12616-12623

40. Girard PR, Stevens VL, Blackshear PJ, Merrill AH Jr, Wood JG & Kuo JR (1987) Immunocytochemical evidence for phorbol ester-induced directional trans-locations of protein kinase C in HL60, K562, CHO and E7SKS cells: Possible role in differentiation. Cancer Res 47: 2892-2898

41. Wilson E, Rice WG, Kinkade JM Jr, Merrill AH Jr, Arnold RR & Lambeth JD (1987) Protein kinase C inhibition by sphingoid long-chain bases: Effects on secretion in human neutrophils. Arch Biochem Biophys 259: 204-214

42. Merrill AH Jr, Wang E & Mullins RE (1988) Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: Effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. Biochemistry 27: 340-345

43. Merrill AH Jr, Wang E, Mullins RE, Jamison WCL, Nimkar S, & Liotta DE (1988) Quantitation of free sphingosine in liver by high-performance liquid chromatography. Anal Biochem 171: 373-381

44. Wilson E, Wang E, Mullins RE, Uhlinger DJ, Liotta DC, Lambeth JD & Merrill AH Jr (1988) Modulation of free sphingosine levels in human neutrophils by phorbol esters and other factors. J Biol Chem 263: 9304-9309

45. Nimkar S, Menaldino D, Merrill AH Jr & Liotta DC (1988) A stereoselective synthesis of sphingosine, a protein kinase C inhibitor. Tetrahedron Lett 29: 3037-3040

46. Medlock KA & Merrill AH Jr (1988) Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by ß-chloroalanine. Biochemistry 27: 7079-7084

47. Medlock KA & Merrill AH Jr (1988) Rapid turnover of sphingosine synthesized de novo from [14C]serine by Chinese hamster ovary cells. Biochem Biophys Res Commun 157: 232-237


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48. Enkvetchakul B, Merrill AH Jr & Birt DF (1989) Inhibition of ornithine decarboxylase activity in mouse epidermis by sphingosine sulfate. Carcinogenesis 10: 379-381

49. Messmer TO, Wang E, Stevens VL & Merrill AH Jr (1989) Sphingolipid biosynthesis by rat liver cells: Effects of serine, fatty acids, and lipoproteins. J Nutr 119: 534-538

50. Merrill AH Jr, Nimkar S, Menaldino D, Hannun YA, Loomis C, Bell RM, Tyagi SR, Lambeth JD, Stevens VL, Hunter R & Liotta DC (1989) Structural requirements for long-chain (sphingoid) base inhibition of PKC C in vitro and the cellular effects of these compounds. Biochemistry 28: 3138-3145

51. Henderson JM, Scott SS, Merrill AH Jr, Hollins B & Kutner MH (1989) Vitamin B6 repletion in cirrhosis with oral pyridoxine: Failure to improve amino acid metabolism. Hepatology 9: 582-588

52. Robertson DG, DiGirolamo M, Merrill AH Jr & Lambeth JD (1989) Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding. J Biol Chem 264: 6773-6779

53. Slife CW, Wang E, Hunter R, Wang S, Burgess C, Liotta DC & Merrill AH Jr (1989) Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum. J Biol Chem 264: 10371-10377

54. Stevens VL, Smith EE, Owens NE, Winton EF, Kinkade JM Jr, & Merrill AH Jr (1989) Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human promyelocytic leukemia (HL-60) cells induced by phorbol esters 1-å,25-dihydroxy-vitamin D3, or ganglioside GM3. Cancer Res 49: 3229-3234

55. Merrill AH Jr, Hoel M, Wang E, Mullins RE, Hargrove JL, Jones DP & Popova IA (1990) Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887. FASEB J 4: 95-100

56. Stevens VL, Nimkar S, Jamison WC, Liotta DC & Merrill AH Jr (1990) Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary (CHO) cells: Evidence for an involvement of protein kinase C. Biochim Biophys Acta 1051: 37-45

57. Stevens VL, Owens NE, Winton EF, Kinkade JM Jr & Merrill AH Jr (1990) Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine. Cancer Res 50: 222-226

58. Yamaka Y, Merrill AH Jr & McCormick DB (1990) Probable reaction mechanisms of flavokinase and FAD synthetase from rat liver. Arch Biochem Biophys 278: 125-130

59. Borek C, Ong A, Stevens VL & Merrill AH Jr (1991) Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol-12-myristate-13-acetate.PNAS (USA) 88: 1953-1957

60. Wang E, Norred WP, Bacon CW, Riley RT & Merrill AH Jr (1991) Inhibition of sphingolipid biosynthesis by fumonisins: Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266: 14486-14490

61. Uhlinger DJ, Burnham DN, Mullins RE, Kalmar JR, Cutler CW, Arnold RR, Lambeth JD & Merrill AH Jr (1991) Functional differences in human neutrophils isolated pre- and postprandially. FEBS Let 286: 28-32

62. Enkvetchakul B, Barnett T, Liotta DC, Geisler V, Menaldino D, Merrill AH Jr & Birt DF (1992) Influences of sphingosine on two-stage skin tumorigenesis in SENCAR mice. Cancer Letters 62: 35-42


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63. Yoo H, Norred WP, Wang E, Merrill AH Jr & Riley RT (1992) Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. Toxicol Appl Pharmacol 114: 9-15

64. Norred WP, Wang E, Yoo H, Riley RT & Merrill AH Jr (1992) In vitro toxicology of fumonisins and the mechanistic implications. Mycopathologia 117: 73-78

65. Wang E, Ross PF, Wilson TM, Riley RT & Merrill AH Jr (1992) Alteration of serum sphingolipids upon dietary exposure of ponies to fumonisins, mycotoxins produced by Fusarium moniliforme. J Nutr 122: 1706-1716

66. Merrill AH Jr, Wang E, Mullins RE, Grindeland RE & Popova IA (1992) Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044. J Appl Physiol 73: 132S-135S

67. Merrill AH, Wang E, LaRocque R, Mullins RE, Morgan ET, Hargrove JL Bonkovsky HL & Popova IA (1992) Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. J Appl Physiol 73: 1420S-1427S

68. Weibking TS, Ledoux DR, Bermudez AJ, Turk JR, Rottinghaus GE, Wang E & Merrill AH Jr (1993) Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. Poultry Sci 72: 456-466

69. Riley RT, An NH, Showker JL, Yoo H-S, Norred WP, Chamberlain WJ, Wang E, Merrill AH Jr, Motelin G, Beasley VR & Haschek WM (1993) Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. Toxicol Appl Physiol 118: 105-112

70. Zhang Z, Smith E, Surowiec SM, Merrill AH Jr, McCormick DB (1993) Synthesis of N-(4’-pyridoxyl) sphingosine and its uptake and metabolism by isolated cells. Membr Biochem 10: 53-59

71. Wu W-I, Lin Y-P, Wang E, Merrill AH Jr & Carman GM (1993) Regulation of phosphatidate phospatase activity fom the yeast Saccharomyces cerevisiae by sphingoid bases. J Biol Chem 268: 13830-13837

72. Merrill AH Jr, van Echten G, Wang E & Sandhoff K (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-actyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J Biol Chem 268: 27299-27306

73. Schroeder JJ, Crane HM, Xia J, Liotta DC & Merrill AH Jr (1994) Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonsin B1: A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.J Biol Chem 269: 3475-3481

74. Dillehay DL, Webb SK, Schmelz E-M & Merrill AH Jr (1994) Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J Nutr 124: 615-620

75. Schmelz E-M, Crall KJ, LaRocque R, Dillehay DL & Merrill AH Jr (1994) Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. J Nutr 124: 702-712

76. Riley RT, Hinton DM, Chamberlain WJ, Bacon CW, Wang E, Merrill AH Jr & Voss KA (1994) Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: A new mechanism of nephrotoxicity. J Nutr 124: 594-603

77. Riley RT, Wang E & Merrill AH Jr (1994) Liquid chromatographic determination of sphinganine and sphingosine: Use of the free sphinganine-to-sphingosine ratio as a biomarker for consumption of fumonisins. J AOAC 77: 533-540

78. Abbas HK, Tanaka T, Duke SO, Porter JK, Wray EM, Hodges L, Sessions AE, Wang E, Merrill AH, Jr & Riley RT (1994) Fumonisin- and AAL-toxin-induced disruption of


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sphingolipid metabolism with accumulation of free sphingoid bases. Plant Physiol 106: 1085-1093

79. Riley RT, Voss KA, Yoo H-S, Gelderblom WCA & Merrill AH Jr (1994) Mechanism of fumonisin toxicity and carcinogenesis. J Food Protection 57: 638-645

80. Merrill AH Jr, Lingrell S, Wang E, Nikolova-Karakashian M & Vance DE (1995) Sphingolipid biosynthesis de novo by rat hepatocytes in culture: Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion J Biol Chem 270: 13834-13841

81. Pushkareva M, Chao R, Bielaskawa A, Merrill AH Jr, Crane HM, Lagu B, Liotta D & Hannun YA (1995) Stereoselectivity of induction of retinoblastoma gene product (Rb) dephosphoryla-tion by D-erthyro-sphingosine supports a role for Rb in growth suppression by sphingosine. Biochemistry 34: 1885-1892

82. Wu W-I, McDonough M, Nickels JT, Jr, Ko J, Fischl AS, Vales TR, Merrill AH, Jr & Carman GM (1995) Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. J Biol Chem 270: 13171-13178

83. Smith ER & Merrill AH Jr (1995) Regulation of the “burst” of free sphingosine and sphinganine, and their 1-phosphate and N-acyl-derivatives, that occurs upon changing the medium of cells in culture: Differential roles of de novo sphingolipid biosynthesis and turnover in J774A.1 macrophages. J Biol Chem 270:18749-18758

84. Ramasamy S, Wang E, Hennig B & Merrill AH Jr (1995) Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol & Applied Pharm 133: 343-348

85. Martinova EM & Merrill AH Jr (1995) Fumonisin B1 alters sphingolipid metabolism and immune function in BALB/c mice. Immunological responses to fumonisin B1. Mycopathologia 130: 163-170

86. Chen J, Nikolova-Karakashian M, Merrill AH Jr & Morgan ET (1995) Regulation of cytochrome P450 2CII (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. J Biol Chem.270: 25233-25238

87. Restum JC, Bursian SJ, Millerick M, Render JA, Merrill AH Jr, Wang E, Rottinghaus GE & Aulerich RJ (1995) Chronic toxicity of fumonisins from Fusarium moniliforme culture material (M-1325) to mink. Environ Contamination & Toxicol. 29: 545-550

88. Zacharias C, van Echten-Deckert G, Wang E, Merrill AH Jr & Sandhoff K (1996) The effect of fumonisin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes. Glycoconjugate J 13: 167-175

89. Schmelz EM, Dillehay D, Webb S, Reiter A, Adams J & Merrill AH Jr. (1996) Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: Implications for dietary sphingolipids and colon carcinogenesis. Cancer Res. 56: 4936-4941

90. Smith ER, Jones PL, Boss JM & Merrill AH Jr (1997) Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases. J Biol Chem 272: 272:5640-5646

91. Schmelz E-M, Bushnev AS, Dillehay DL, Liotta DC & Merrill AH Jr (1997) Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with either saturated or unsaturated sphingoid base backbones. Nutr & Cancer 28: 81-85

92. Nikolova-Karakashian M, Morgan ET, Alexander C, Liotta DC & Merrill AHM Jr (1997)


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Bimodal regulation of ceramidase by interleukin-1b: Implications for the regulation of cytochrome P450 2C11 (CYP2C11). J Biol Chem 272: 18718-18724

93. Kok JW, Nikolova-Karakashian M, Klappe K, Alexander C & Merrill AH Jr (1997) Dihydroceramide biology: structure specific metabolism and intralcellular localization. J Biol Chem 272: 21128-21136

94. Nikolova-Karakashian M, Russell RW, Booth RA, Jenden DJ & Merrill AH Jr (1997) Sphingomyelin metabolism in rat liver after chronic dietary replacement of choline by N-aminodeanol. J Lipid Res 38: 1764-1770

95. Michel C, van Echten-Deckert G, Rother J, Sandhoff K, Wang E & Merrill AH Jr (1997) Characterization of ceramide synthesis: A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J Biol Chem 292: 22432-22437

96. Schmelz EM, Dombrink-Kurtzman MA, Kozutsumi Y & Merrill AH Jr (1998) Induction of apoptosis by Fumonisin B1 in HT-29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol & Appl Pharmacol 148: 252-260

97. Ciacci-Zanella JR, Merrill AH Jr, Wang E & Jones C (1998) Characterization of cell-cycle arrest by Fumonisin B1 in CV-1 cells. Food Chem Toxicol 36: 791-804

98. Birt DF, Merrill AH Jr, Barnett T, Enkvetchakul B, Pour PM, Liotta DC, Geisler V, Menaldino DS & Schwartzbauer J (1998) Inhibition of skin papillomas by sphingosine, N-methyl sphingosine, and N-acetyl sphingosine. Nutr Cancer 31: 119-126

99. Abbas HK, Duke SO, Merrill AH Jr, Wang E & Shier WT (1998) Phytotoxicity of australifungin, AAL-toxins and fumonisin B1 to Lemma pausicostata. Phytochemistry 47: 1509-1514.

100. Humpf H-U, Schmelz E-M, Meredith FI, Vesper H, Vales TR, Menaldino DS, Liotta DC & Merrill AH Jr (1998) Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase: Formation of N-palmitoyl-aminopentol (PAP1) produces a toxic metabolite of hydrolyzed fumonisin (AP1), and a new category of ceramide synthase inhibitor. J Biol Chem 273: 19060-19064

101. Wang E, Riley RE, Meredith FI & Merrill AH Jr (1999) Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine. J Nutr 129:214-220

102. Augé N, Nikolova-Karakashian M, Carpentier S, Parthasarathy S, Nègre-Salvayre A, Salvayre R, Merrill AH Jr & Levade T (1999) Role of sphingosine-1-phosphate in the mitogenesis induced by oxidized LDL in smooth muscle cells via activation of sphingomyelinase, ceramidase and sphingosine kinase. J Biol Chem 274:21533-21538

103. Meredith FI, Torres OR, Riley RT & Merrill AH Jr. (1999) Fumonisin B1 and hydrolyzed fumonisin B1 (AP1) in tortillas and nextamalized maize (Zea mays L.) from two different geographical locations in Guatemala. J. Food Protection 62:1218-1222.

104. Schmelz EM, Bushnev AS, Dillehay DL, Sullards MC, Liotta DC & Merrill AH Jr. (1999) Ceramide ß-D-glucuronide: synthesis, digestion and suppression of early biomarkers of colon carcinogenesis. Cancer Res. 59:5768-5772.

105. Warden, L. A., Menaldino, D. S., Wilson, T., Liotta, D. C., Smith, E. R. and Merrill, A. H., Jr. (1999) Identification of ammonium ion and 2,6-bis-(γ-aminobutyl)-3,5-diimino-piperazine as endogenous factors that account for the “burst” of sphingosine upon changing the medium of J774 cells in culture J. Biol. Chem. 274:33875-33880

106. Schmelz EM, Sullards MC, Dillehay DL & Merrill AH Jr. (2000) Inhibition of colonic cell


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proliferation and aberrant crypt foci formation by dietary glycosphingolipids in 1,2-dimethylhydrazine-treated CF1 mice. J. Nutr. 130:522-527.

107. Sullards MC, Lynch DV, Schmelz EM, Merrill AH Jr & Adams, J. (2000) Analysis of soybean and wheat glycosylceramides by tandem mass spectrometry J. Mass Spectrometry 35: 347-353.

108. Carsten Grullich C, Sullards MC, Fuks Z, Merrill AH Jr and Kolesnick R. (2000) CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis J. Biol. Chem. 275:8650-8656.

109. Caligan TB, Peters K, Ou J, Wang E & Merrill AH Jr. (2000) A high performance liquid chromatographic method to measure sphingosine 1-phosphates and analogs from sphingosine kinase assays and biological samples. Anal. Biochem. 281:36-44.

110. Abnet CC, Borkowf CB, Qiao Y-L, Albert PS, Wang EW, Merrill AH Jr., Mark SD, Dong Z-W, Taylor PR and Dawsey SM (2001) Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in China. Cancer Causes Control. 12:821-828.

111. Abnet, CC, Borkowf CB, Qiao Y-L, Albert PS, Wang E, Merrill, A. H. Jr. Mark SD, Dong, Z-W, Taylor PR, and Dawsey SM (2001) A Cross-Sectional Study of Human Serum Sphingolipids, Dietary and Physiological Parameters. J Nutr 131:2748-2752.

112. Schmelz EM, Roberts, PC, Kustin EM, Lemonnier LA, Sullards MC, Dillehay DL, and Merrill AH Jr. (2001) Modulation of intracellular β-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res. 61:6723-6729.

113. Hitt, EP, DeLong, MJ and Merrill, AH Jr. (2002) Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H quinone reductase activity and cell proliferation. Toxicol. Appl. Pharmacol. 183:160-167.

114. Venkataraman K, Riebeling C, Bodennec J, Riezman H, Allegood JC, Sullards MC, Merrill AH Jr, Futerman AH. (2002) Up-stream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. J Biol Chem. 277: 35642–35649.

115. Sadler TW, Merrill AH, Stevens VL, Sullards MC, Wang E, Wang P. (2002) Prevention of fumonisin B1-induced neural tube defects by folic acid. Teratology 66:169-176.

116. Menaldino DS, Bushnev A, Sun A, Liotta DC, Symolon H, Desai K, Dillehay DL, Peng Q, Wang E, Allegood J, Trotman-Pruett S, Sullards MC, Merrill AH. (2003) Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action. Pharmacol Res. 47:373-81.

117. Sullards MC, Wang E, Peng Q and Merrill AH Jr (2003) Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry, Cell Mol. Biol. 49(5):789-797.

118. Riebeling C, Allegood JC, Wang E, Merrill AH Jr, Futerman AH. (2003) Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem. 278:43452-43459.

119. Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH Jr, Saba JD (2004) Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 279:1281-1290.

120. Dedov VN, Dedova IV, Merrill AH Jr, Nicholson GA. (2004) Activity of partially inhibited


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serine palmitoyltransferase is sufficient for normal sphingolipid metabolism and viability of HSN1 patient cells. Biochim Biophys Acta. 1688:168-175.

121. Symolon H, Schmelz EM, Dillehay DL &, Merrill AH Jr. (2004) Dietary soy sphingolipids suppress tumorigenesis and gene expression in mouse models of colon cancer. Symolon H, Schmelz EM, Dillehay DL, Merrill AH Jr. J Nutr. 134:1157-1161.

122. Monick MM, Mallampalli RK, Bradford M, McCoy D, Gross TJ, Flaherty DM, Powers LS, Cameron K, Kelly S, Merrill AH Jr, Hunninghake GW. (2004) Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. J Immunol. 173:123-35.

123. Ozbay T, Merrill AH Jr, Sewer MB (2004) ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. Endocr Res. 30:787-794.

124. Maceyka M, Sankala H, Le Stunff H, Liu H , Toman R, Hait NC, Zhang M, Satin L, Merrill AH Jr, Milstien S and Spiegel S (2005) SphK1 and SphK2: Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism, J. Biol Chem. 280(44):37118-29. Computationally predicting rate constants in pathway models.

125. Henning P, Moffitt R, Allegood J, Wang E, Merrill A, and M Wang (2005) Computationally predicting rate constants in pathway models. Conf Proc IEEE Eng Med Biol Soc, January 1, 2005; 5: 5093-6.

126. Missmer SA, Suarez L, Felkner M, Wang E, Merrill AH Jr, Rothman KJ and Hendrick KA (2006) Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border, Environmental Health Perspectives 114(2):237-41.

127. Dougherty AM, McDonald FE, Liotta DC, Moody SJ, Pallas DC, Pack CD, Merrill, AH (2006) Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups. Org Lett. 8(4):649-52.

128. Rittershaus PC, Kechichian, TB., Allegood JC, Merrill AH Jr, Hennig M, Luberto C & Del Poeta M (2006) Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. J. Clinical Invest. 116(6):1651-9.

129. Fox TE, Han X, Kelly S, Merrill AHJr, Martin RE, Anderson RE, Gardner TW and Kester M (2006) Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes 55(12):3573-80.

130. Dragusin M, Wehner S, Kelly S, Wang E, Merrill AH Jr. , Kalff JC & van Echten-Deckert G (2006) Proinflammatory action of sphingosine-1-phosphate and of ceramide-1-phosphate in primary cultured rat intestinal smooth muscle cells. Possible implications in postoperative ileus. FASEB J. 20:1930-2.

131. Giussani P, Maceyka MW, Le Stunff H, Mikami A, Lepine S, Wang E, Kelly S, Merrill AH Jr., Milstien S and Spiegel S (2006) Sphingosine 1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-Golgi trafficking of ceramide, Mol. Cell. Biol. 26(13):5055-69.

132. Linn SC, Andras LM, Kim H-S., Wei J, Nagiec MM, Dickson RC and Merrill AH Jr. (2006) Functional characterization of the promoter for the mouse SPTLC2 gene, which encodes subunit 2 of serine palmitoyltransferase, FEBS Lett. 580: 6217-23.

133. Brimble SN, Sherrer ES, Uhl EW, Wang E, Kelly S, Merrill AH Jr, Robins AJ and Schulz TC (2007) The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ES cell pluripotency. Stem Cell 25(1):54-62.

134. Urs AN, Dammer E, Kelly S, Wang E, Merrill AH Jr, Sewer MB (2007) Steroidogenic


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factor-1 is a sphingolipid binding protein ol Cell Endocrinol. 265-266:174-8. 135. Finnegan CM, Rawat SS, Cho EH, Guiffre DL, Lockett S, Merrill AH Jr, Blumenthal R.

(2007) Sphingomyelinase Restricts the Lateral Diffusion of CD4 and Inhibits HIV Fusion. J. Virol. 81(10):5294-304

136. Lamour NF, Stahelin RV, Wijesinghe DS, Maceyka M, Wang E, Allegood JC, Merrill AH Jr, Cho W, Chalfant CE. (2007) Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. J Lipid Res. 2007 Jun;48(6):1293-304.

137. Morales PR, Dillehay DL, Moody SJ, Pallas DC, Pruett S, Allgood JC, Symolon H, Merrill AH Jr.(2007) Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation. Drug Chem Toxicol. 30(3):197-216.

138. Rao RP, Yuan C, Allegood JC, Rawat SS, Edwards MB, Wang X, Merrill AH Jr, Acharya U, Acharya JK. (2007) Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. Proc Natl Acad Sci U S A. 104(27):11364-9.

139. Li D, Urs AN, Allegood J, Leon A, Merrill AH Jr, Sewer MB. (2007) cAMP-Stimulated Interaction Between Steroidogenic Factor-1 and Diacylglycerol Kinase-{theta} Facilitates Induction of CYP17. Mol Cell Biol. 27(19):6669-85.

140. Wu D, Ren Z, Pae M, Guo W, Cui X, Merrill AH, Meydani SN (2007) Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue, J. Immunol. 179: 4829–4839.

141. Seiferlein M, Humpf HU, Voss KA, Sullards MC, Allegood JC, Wang E, Merrill AH Jr. Hydrolyzed fumonisins HFB(1) and HFB(2 )are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. Mol Nutr Food Res. 51(9):1120-1130

142. Dhingra S, Freedenberg M, Quo CF, Merrill AH Jr, Wang MD. (2007) Computational modeling of a metabolic pathway in ceramide de novo synthesis. Conf Proc IEEE Eng Med Biol Soc. 2007:1405-8.

143. Torres OA, Palencia E, Lopez de Pratdesaba L, Grajeda R, Fuentes M, Speer MC, Merrill AH Jr, O'Donnell K, Bacon CW, Glenn AE, Riley RT (2007) Estimated fumonisin exposure in Guatemala is greatest in consumers of lowland maize. J Nutr. 137(12):2723-9.

144. Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, Merrill AH Jr, Futerman AH. (2008) Characterization of Ceramide Synthase 2: Tissue distribution, substrate specificity, and inhibhtion by sphingosine 1-phosphate. J Biol Chem. 283(9):5677-84.

145. Haynes CA, Allegood JC, Sims K, Wang EW, Sullards MC, Merrill AH Jr. (2008) Quantitation of fatty acyl-coenzyme A molecular species in mammalian cell extracts by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI MS/MS). J Lipid Res. 49(5):1113-25.

146. Kapoor S, Quo CF, Merrill AH, Wang MD. (2008) An interactive visualization tool and data model for experimental design in systems biology. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2423-6.

147. Chen Y, Allegood JC, Liu Y, Wang E, Cox TM, Merrill AH Jr, Sullards MC (2008) Imaging MALDI Mass Spectrometry Using an Oscillating Capillary Nebulizer Matrix Coating System and Its Application to Analysis of Lipids in Brain from a Mouse Model of Tay-Sachs/Sandhoff Disease, Anal Chem. 80(8):2780-2788.

148. Machesky NJ, Zhang G, Raghavan B, Zimmerman P, Kelly SL, Merrill AH Jr, Waldman WJ, Van Brocklyn JR, Trgovcich J. (2008) Human cytomegalovirus regulates bioactive


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sphingolipids. J Biol Chem. 283(38):26148-60. 149. Wang H, Mauer BJ, Liu Y-Y, Wang E., Allegood JC, Kelly S., Symolon H, Liu Y, Merrill

AH Jr, Gouazé-Anderson V, Yu J Y, Giuliano AE and Cabot MC (2008) N-(4-hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphongosine to enhance cancer cell killing. Mol. Cancer Ther. 7: 2967-2976.

150. Shaner RL, Allegood JC, Park H, Wang E, Kelly S, Haynes CA, Sullards MC, Merrill AH Jr. (2009) Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers. J Lipid Res. 2008 Nov 25. [Epub ahead of print]

151. Coward J, Ambrosini G, Haimovitz-Friedman A, Truman J-P, Allegood JC, Merrill AH Jr.3 and Schwartz GK (2009) Safingol (L-threo-sphinganine) Induces Autophagy involving inhibition of PKCε and PI3k. Autophagy 5(2):184-93.

152. Deevska GM, Rozenova KA, Giltiay NV, Chambers MA, White J, Boyanovsky BB, Wei J, Daugherty A, Smart EJ, Reid MB, Merrill AH Jr, Nikolova-Karakashian MN. (2009) Acid sphingomyelinase deficiency prevents diet-induced hepatic triacylglycerol accumulation and hyperglycemia in mice. J Biol Chem. 2008 Dec 11. [Epub ahead of print]

153. Zitomer NC, Mitchell T, Voss KA, Bondy GS, Pruett ST, Garnier-Amblard EC, Liebeskind LS, Park H, Wang E, Sullards MC, Merrill AH Jr, Riley RT. (2009) Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxy-sphinganine: A novel category of bioactive 1-deoxy-sphingoid bases and 1-deoxy-dihydroceramides biosynthesized by mammalian cell lines and animals. J Biol Chem. 284(8):4786-95.

154. Hagen N, Van Veldhoven PP, Proia RL, Park H, Merrill AH Jr, Van Echten-Deckert G. (2009) Subcellular origin of sphingosine-1-phosphate is essental for its toxic effect in lyase deficient neurons. J Biol Chem. 284:11346-53

155. Wei J, Yerokun T, Leipelt M, Haynes CA, Radhakrishna H, Momin A, Kelly S, Park H, Wang E, Carton JM, Uhlinger DJ, Merrill AH Jr. (2009) Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology. Biochim Biophys Acta. 1791:746-56.

156. Goldfinger M, Laviad EL, Hadar R, Shmuel M, Dagan A, Park H, Merrill AH Jr, Ringel I, Futerman AH, Tirosh B (2009) De novo ceramide synthesis is required for N-linked glycosylation in plasma cells. J Immunol. 182:7038-47.

157. Momin AA, Park H, Allegood JC, Leipelt M, Kelly SL, Merrill AH Jr, Hanada K. (2009) Characterization of mutant serine palmitoyltransferase 1 in LY-B cells. Lipids. 44:725-32.

158. Hu W, Bielawski J, Samad F, Merrill AH Jr, Cowart LA (2009) Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. J Lipid Res. 50(9):1852-62.

159. Park H, Haynes CA, Nairn AV, Kulik M, Dalton S, Moremen K, Merrill AH Jr. (2010) Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J Lipid Res. 51(3):480-9

160. Yin J, Miyazaki K, Shaner RL, Merrill AH Jr, Kannagi R. (2010) Altered sphingolipid metabolism induced by tumor hypoxia - New vistas in glycolipid tumor markers. FEBS Lett. 584:1872-8.

161. Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brugger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH. (2010) A critical role for ceramide synthase 2 in liver homeostasis: I. Alterations in lipid metabolic pathways. J Biol Chem. 285:10902-10.


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162. Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH. (2010) A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem. 285:10911-23

163. Bushnev AS, Baillie MT, Holt JJ, Menaldino DS, Merrill AH Jr. and Dennis C. Liotta DC (2010) An efficient asymmetric synthesis of Enigmols (1-deoxy-5-hydroxysphingoid bases), an important class of bioactive lipid modulators. ARKIVOC 2010 (viii) 00-00.

164. Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, Raetz CR, Russell DW, Subramaniam S, Dennis EA. (2010) Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res. 51(9):2785-97.

165. Liu Y, Chen Y, Momin A, Shaner R, Wang E, Bowen NJ, Matyunina LV, Walker LD, McDonald JF, Sullards MC, Merrill AH Jr. (2010) Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry. Mol Cancer. 2010 Jul 12;9:186.PMID: 20624317

166. Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA. (2010) Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res. 51:3299-305. PMID: 20671299

167. Sims K, Haynes CA, Kelly S, Allegood JC, Wang E, Momin A, Leipelt M, Reichart D, Glass CK, Sullards MC, Merrill AH Jr. (2010) Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. J Biol Chem. 285:38568-79. PMID: 20876532

168. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S. (2010) A mouse macrophage lipidome. J Biol Chem. 285:39976-85. PMID: 20923771

169. Dickson MA, Carvajal RD, Merrill AH, Gonen M, Cane LM, Schwartz GK. (2011) A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors. Clin Cancer Res. 2011 Apr 15;17(8):2484-92. Epub 2011 Jan 21.PMID:21257722

170. Gupta S, Maurya MR, Merrill AH Jr, Glass CK, Subramaniam S (2011) Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism, BMC Syst Biol. 2011 Feb 8;5:26. PMID: 21303545

171. Quo CF, Moffitt RA, Merrill AH, Wang MD. (2011) Adaptive control model reveals systematic feedback and key molecules in metabolic pathway regulation. J Comput Biol. 2011 Feb;18(2):169-82. PMID:21314456

172. Symolon H, Bushnev A, Peng Q, Ramaraju H, Mays SG, Allegood JC, Pruett ST, Sullards MC, Dillehay DL, Liotta DC, Merrill AH Jr. (2011) Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer. Mol Cancer Ther. 2011 Apr;10(4):648-57. PMID:21398423

173. Momin AA, Park H, Portz BJ, Haynes CA, Shaner RL, Kelly SL, Jordan IK, Merrill AH Jr. (2011) A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences. J Lipid Res. 2011 Jun;52(6):1073-83.


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PMID:21415121 174. Haynes CA, Allegood JC, Wang EW, Kelly SL, Sullards MC, Merrill AH Jr. (2011)

Factors to consider in using [U-13C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry. J Lipid Res. 52(8):1583-94, PMID: 21586681

175. Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brugger B, Merrill AH Jr, Futerman AH. (2011) Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels. J Biol Chem. 286:30022-33 PMID: 21705317

176. Tidhar R, Ben-Dor S, Wang E, Kelly S, Merrill AH Jr, Futerman AH. (2011) The acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain. J Biol Chem. 287(5):3197-206 PMID 22144673

177. Silva LC, Ben David O, Pewzner-Jung Y, Laviad EL, Stiban J, Bandyopadhyay S, Merrill AH Jr, Prieto M, Futerman AH. (2012) Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes J. Lipid Res. 53(3):430-6

178. Lucki NC, Bandyopadhyay S, Wang E, Merrill AH, Sewer MB. (2012) Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression. Mol Endocrinol. 26(2):228-43. PMID: 22261821

179. Hagen-Euteneuer N, Luetjohann D, Park H, Merrill AH Jr, van Echten-Deckert G. (2012) S1P-lyase-deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons. J Biol Chem. 287(12):9128-36. PMID: 22291021

180. Laviad EL, Kelly S, Merrill AH Jr, Futerman AH. (2012) Modulation of ceramide synthase activity via dimerization. J Biol Chem. 287(25):21025-33. PMID: 22539345

181. Lucki NC, Li D, Bandyopadhyay S, Wang E, Merrill AH, Sewer MB. (2012) Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor. Mol Cell Biol. 32(21):4419-31. PMID: 22927646

182. Martinez TN, Chen X, Bandyopadhyay S, Merrill AH, Tansey MG. (2012) Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons. Mol Neurodegener. 2012 Sep 13;7:45. doi: 10.1186/1750-1326-7-45. PMID: 22973882 (Online publication)

183. Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. (2012) Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 151(1):138-52. PMID: 23021221

184. Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN. (2012) Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction. PLoS One. 2012;7(10):e47650. doi: 10.1371/journal.pone.0047650. PMID: 23110086

185. Morad SA, Messner MC, Levin JC, Abdelmageed N, Park H, Merrill AH Jr, Cabot MC. (2013) Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells. Cancer Chemother Pharmacol. 71(3):635-45. doi: 10.1007/s00280-012-2050-4. PMID 23263160


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186. Zigdon H, Kogot-Levin A, Park JW, Goldschmidt R, Kelly S, Merrill AH Jr, Scherz A, Pewzner-Jung Y, Saada A, Futerman AH. (2013) Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress due to Disruption of the Mitochondrial Respiratory Chain. J Biol Chem. 288(7):4947-56. doi: 10.1074/jbc.M112.402719. PMID:23283968

187. Park WJ, Park JW, Erez-Roman R, Kogot-Levin A, Bame JR, Tirosh B, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH. (2013) Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization. J Biol Chem. 288(43):30904-16. doi: 10.1074/jbc.M112.448852. PMID:24019516

188. Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. (2013) 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. PMID:24189069

189. Farfel-Becker T, Vitner EB, Kelly SL, Bame JR, Duan J, Shinder V, Merrill AH Jr, Dobrenis K, Futerman AH. (2014) Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration. Hum Mol Genet. 23(4):843-54. doi: 10.1093/hmg/ddt468. PMID:24064337

190. Pinto SN, Laviad EL, Stiban J, Kelly SL, Merrill AH Jr, Prieto M, Futerman AH, Silva LC. (2014) Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain. J Lipid Res. 2014 Jan;55(1):53-61. doi: 10.1194/jlr.M042002. PMID:24163422

(Sometimes) Non-Refereed Publications: (Reviews and Book Chapters): 1. Merrill AH Jr & McCormick DB (1979) Flavin affinity chromatography. In: Meth

Enzymology (McCormick DB & Wright LD eds) Acad. Press, NY, 66: 338-344 2. Merrill AH Jr. & McCormick DB (1979) Preparation of flavin 5’-phosphates using

immobilized flavokinase. In: Meth Enzymology (McCormick DB & Wright LD eds) Acad. Press, NY, 66, 287-290

3. Merrill AH Jr, Kazarinoff MN, Tsgue H, Horiike K & McCormick DB (1979) 4. Campbell TC, Hayes JR, Merrill AH Jr, Maso M & Goetchius M (1979) The influence of

dietary factors on drug metabolism in animals. Drug Metab Rev 9: 173-184 5. Merrill, A.H., Jr., Lambeth, J.D., Edmondson, D.E. & McCormick, D.B. (1981) Formation

and mode of action of flavoproteins. Annu Rev Nutr 1: 281-317 6. McCormick DB, Innis WSA, Merrill AH Jr & Lee SS (1984) Mammalian metabolism of

flavins. In: Flavins and Flavoproteins (Bray RD, Engel PC & Mayhew SG eds), Walter DeGruyter & Co., Berlin, 833-846

7. Merrill AH Jr & Nichols JW (1985) Techniques for studying phospholipid membranes. In: Phospholipids and Cellular Regulation (Kuo JF ed) CRC Press, Boca Raton, FL, 61-96

8. Merrill AH Jr & Wang E (1986) Highly sensitive methods for assaying the enzymes of vitamin B6 metabolism. In: Meth Enzymology: Vitamins and Coenzymes (McCormick DB & Chytil F eds) Acad. Press, NY, 122: 110-116

9. Pyridoxamine (pyridoxine) 5’-phosphate oxidase from rabbit liver. In: Meth Enzymology


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(McCormick DB & Wright LD eds) Acad. Press, NY, 672, 568-574 10. McCormick DB & Merrill AH Jr (1980) Pyridoxamine (pyridoxine) 5’-phosphate oxidase.

In: Vitamin B6: Its Metabolism and Influence on the Processes of Growth (Tryfiates GP, ed.) Food and Nutrition Press, Westport CT, 1-26

11. Henderson JM & Merrill AH Jr (1987) Diseases associated with defects in vitamin B6 metabolism or utilization. Ann Rev Nutr 7: 137-156

12. Henderson JM, Hollins B, Wang E & Merrill AH Jr (1987) Metabolism of vitamin B6 by human subjects with and without normal liver function. In: Biochemistry of Vitamin B6: Proc Int’l Congress on Chemical and Biological Aspects of Vitamin B6 Catalysis (Korpela T & Christen P eds) Birkhauser Verlag, Basel 2: 417-420

13. Merrill AH Jr, Innis-Whitehouse WSA & McCormick DB (1987) Isolation and characterization of riboflavin-binding immunoglobulins from normal human serum. In: Flavins and Flavoproteins, 9th Int’l. Sympos. (McCormick DB & Edmondson DE eds) Walter DeGruyter & Co., Berlin, 445-448

14. McCormick DB, Innis WSA, Merrill AH Jr, Bowers-Komro D, Oka M, & Chastain JL (1987) Update on flavin metabolism in rats and humans. In: Flavins and Flavoproteins, 9th Int’l. Sympos. (McCormick DB & Edmonson DE eds) Walter DeGruyter & Co., Berlin, 459-471

15. White HB III & Merrill AH Jr (1988) Riboflavin-binding proteins. Ann Rev Nutr 8: 279-299

16. Merrill AH Jr & Stevens VL (1989) Modulation of protein kinase C and diverse cell functions by sphingosine - a pharmacologically interesting compound linking sphingolipids and signal transduction. Biochim Biophys Acta 1010: 131-139

17. Merrill AH (1989) Lipid modulators of cell function. Nutr Rev 47: 161-169 18. Merrill AH Jr. & Burnham FS (1990) Vitamin B6 In: Present Knowledge in Nutrition

(Brown ML ed) Internat. Life Sciences Inst., The Nutrition Fndation, Wash, DC 155-162 19. Merrill AH Jr & Henderson JM (1990) Vitamin B6 metabolism by human liver. Ann NY

Acad Sci 585: 110-117 20. Merrill AH Jr & Jones DD (1990) An update of the enzymology and regulation of

sphingomyelin metabolism. Biochim Biophys Acta 1044: 1-12 21. Merrill AH Jr (1991) Cell regulation by sphingosine and more complex sphingolipids. J

Bioenerget Biomemb 23: 83-104 22. Merrill AH Jr, Foltz A, Nixon DW & McCormick DB (1991) Vitamins and cancer. In:

Human Nutrition: A Comprehensive Treatise (Alfin-Slater R & Kritchevsky D eds), Plenum Press, NY, 261-320

23. Hannun YA, Merrill AH Jr & Bell RM (1991) Use of sphingosine as inhibitor of protein kinase C. In: Meth Enzymology 201: 316-328

24. Merrill AH Jr & Liotta DC (1991) Lipids as hormones and second messengers. In: Current Opinion in Structural Biology 1: 516-521

25. Merrill AH Jr (1992) Long-chain fatty acids and other lipid second messengers. In: Polyunsaturated Fatty Acids in Human Nutrition (Bracco U & Deckelbaum RJ eds) 28: 41-52

26. Merrill AH Jr (1992) Ceramide: A new lipid “second messenger”? Nutr Rev 50: 78-80 27. Merrill AH Jr & Wang E (1992) Enzymes of ceramide biosynthesis. In: Meth Enzymology

(Dennis EA & Vance DE eds) 209: 427-437 28. Merrill AH Jr & Schroeder JJ (1993) Lipid modulation of cell function. Ann Rev Nutr 13:


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539-559 29. Merrill AH Jr, Hannun YA & Bell RM (1993) Sphingolipids and their metabolites in cell

regulation. In: Advances in Lipid Research: Sphingolipids and Their Metabolites (Bell RM, Hannun YA & Merrill AH Jr eds), Acad. Press, San Diego, CA 25: 1-24

30. Merrill AH Jr, Wang E, Gilchrist DG & Riley RT (1993) Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. In: Advances in Lipid Research: Sphingolipids and Their Metabolites (Bell RM, Hannun YA & Merrill AH Jr eds) Acad. Press, San Diego, CA 26: 215-234

31. Borek C & Merrill AH Jr (1993) Sphingolipids inhibit multistage carcinogenesis and protein kinase C. In: Antimutagenesis and Anticarcinogenesis Mechanisms III (Bronzetti, G, Hayatsu M, DeFlora S, Waters MD & Shankel DM eds) Plenum Press, NY, 367-371

32. Merrill AH Jr (1994) Sphingosine and other long-chain bases that alter cell behavior. In: Current Topics in Membranes: Cell Lipids (Hoekstra D ed) Acad. Press NY, 40: 361-386

33. Riley RT, Voss KA, Yoo H-S, Gelderblom WCA & Merrill AH Jr (1994) Mechanism of fumonisin toxicity and carcinogenesis. J Food Protection 57: 638-645

34. Merrill AH Jr (1994) APO-IV: A new satiety signal. Nutr Rev. 51:273-275 35. Merrill AH Jr, Wang E, Schmelz E-R, Wang E, Schroeder JJ, Dillehay DL & Riley RT

(1995) Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. J Nutr 125: 1677S-1682S

36. Merrill AH Jr, Wang E, Schroeder JJ, Smith ER, Yoo H-S & Riley RT (1994) Disruption of sphingolipid metabolism in the toxicity and carcinogenicity of fumonisins. In: Molecular Approaches to Food Safety Issues Involving Toxic Microorganisms (Eklund M, Richards J & Mise K eds) Chap 30, Alaken Press Inc., Fort Collins, CO, 429-443

37. Merrill AH Jr, Wang E, Vales TR, Smith ER, Schroeder JJ, Menaldino DS, Alexander C, Crane HM, Xia J, Liotta DC, Meredith FI & Riley RT (1996) Fumonisin toxicity and sphingolipid biosynthesis. In: Fumonisins in Food (Jackson L, de Vries, JW & Bullerman LB eds) 25: Plenum Press, NY, 297-306

38. Merrill AH, Jr., Liotta, DC & Riley RE (1996) Fumonisins: Fungal toxins that shed light on sphingolipid function. Trends in Cell Biology 6: 218-223

39. Morgan ET, Nikolova-Karakashian M, Chen J-Q & Merrill AH Jr (1996) Sphingolipid-dependent signaling in regulation of cytochrome P450 expression. Meth Enzymol 272: 381-388

40. Merrill AH Jr, Liotta DC & Riley RE (1996) Bioactive properties of sphingosine and structurally related compounds. In: Handbook of Lipid Research:. Lipid Second Messengers (Bell RM, Exton JH & Prescott SM eds) Plenum Press, NY 8: 205-237

41. Riley RT, Wang E, Schroeder JJ, Smith ER, Plattner RD, Abbas H, Yoo H-S & Merrill AH Jr (1996) Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins. Natural Toxins 4: 3-15

42. Merrill AH Jr, Liotta DC & Riley RE (1996) Sphingolipids as regulators of cellular growth, differentiation, and behavior. Adv Lipobiol (Gross RW ed) 1: 273-298

43. Merrill AH Jr, Grant AM, Wang E & Bacon CW (1996) Lipids and lipid-like compounds of Fusarium. In: Lipids of Pathogenic Fungi (Prasad R & Ghannoun eds) Chap. 9, CRC Press, Boca Raton, FL, 199-217

44. Merrill AH Jr. & Sweeley CC (1996) Sphingolipids: metabolism and cell signalling. In: New Comprehensive Biochemistry: Biochemistry of Lipids,Lipoproteins,and Membranes (Vance DE &Vance JE eds) Elsevier Science Publ., Amsterdam 31: 309-338


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45. Spiegel S & Merrill AH Jr (1996) Sphingolipid metabolism and growth regulation: A state-of-the-art review. FASEB J 10: 1388-1397

46. Riley RT, Liotta DC & Merrill AH Jr (1996) Sphingolipid analogue biomodulators in foods alter sphingolipid metabolism. Implications for health and disease. Proc Nutr Soc Australia 20: 124-131

47. Merrill AH Jr, Schmelz E-M, Wang E, Dillehay DL, Rice LG, Meredith FI & Riley RT (1996) Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets. J Nutr 127: 830S-833S

48. Merrill AH Jr, Schmelz E-M, Dillehay DL, Spiegel S, Shayman JA, Schroeder JJ, Riley RT & Wang E (1997) Sphingolipids. The enigmatic lipid class: biochemistry, physiology and pathophysiology. Toxicol & Appl Pharm 142: 208-225

49. Nikolova-Karakashian M, Vales TR, Wang E, Menaldino DS, Alexander C, Goh J, Liotta DC & Merrill AH Jr (1997) Ceramide synthase and ceramidases in the regulation of sphingoid base metabolism. In: Sphingolipid-mediated Signal Transduction, Molecular Biology Intelligence Unit (Hannun YA ed) R. G. Landes Co., 159-172

50. Schmelz E-M & Merrill AH Jr (1998) Ceramides and ceramide metabolites in cell regulation. Evidence for dietary sphingolipids as inhibitors of colon carcinogenesis. Nutr 14: 717-719

51. Norred WP, Voss KA, Riley RT, Meredith FI, Bacon CW & Merrill AH Jr (1998) Toxicological aspects and mechanism of action of fumonisins. J Toxicol Sci 23: 160-164

52. Riley RT, Voss KA, Norred WP, Sharma RP, Wang E & Merrill AH Jr (1998) Fumonisins: mechanism of cytotoxicity. Revue Médicine Vétérinaire 149:617-626

53. Vesper H, Schmelz E-M, Nikolova-Karakashian MN, Dillehay DL, Lynch DV & Merrill AH Jr (1999) Sphingolipids in food and the emerging importance of sphingolipids in nutrition. J Nutr 129: 1239-1250

54. Wang E & Merrill AH Jr (2000) Ceramide synthase. Methods Enzymol. Vol. 311:15-21. 55. Nikolova-Karakashian MN & Merrill AH, Jr. (2000) CeramidasesMethods Enzymol. Vol.

311:194-201 56. Riley RT, Enongen E, Voss KA, Norred WP, Meredith FI, Sharma RP, Williams D, Merrill

AH Jr (2001) Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ. Health Perspectives 109: Suppl 2: 301-308

57. Riley RT, Norred WP, Wang E and Merrill AH Jr. (1999) Alteration in Sphingolipid Metabolism: Bioassay for Fumonisin- and ISP-I -like Activity in Tissues, Cells, and Other Matrices. Nat. Toxins Nov 7(6): p. 407-414

58. Merrill AH Jr, Sullards, MC, Wang E, Voss, KA and Riley RT (2001) Sphingolipid metabolism: Roles in signal transduction and disruption by fumonisins. Environ. Health Perspectives 109 Suppl 2: 283-289.

59. Merrill, A. H., Jr., Morgan, E. T., Nikolova-Karakashian, M. N. and Stewart, J. (1999) Sphingomyelin hydrolysis and regulation of cytochrome P450 gene expression, Biochem. Soc.Trans. 27:383-387

60. Merrill AH Jr, Caligan TB, Wang E, Peters K and Ou J (2000) Analysis of sphingoid bases and sphingoid base 1-phosphates by high performance liquid chromatography. Methods Enzymol. Vol. 312: 3-9.

61. Smith ER, Merrill AH Jr., Obeid, LM and Hannun, YA (2000) Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. Vol. 312: 361-373

62. Merrill AH Jr. (2000) Compilation of methods published in previous volumns of Methods


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in Enzymology, Methods Enzymol. Vol. 312: 583-592. 63. Merrill AH Jr., Nikolova-Karakashian, M., Schmelz, E.M., Morgan E.T., and Stewart, J.

(1999) Regulation of cytochrome P450 expression by sphingolipids. Chem. Phys. Lipids 102: 131-139

64. Merrill AH Jr, Wang E, Torres O, Saenz de Tejda S, Meredith FI and Riley RT, (2000) Occurrence, toxicity, mechanism of action, and health implications of fumonisins for the Americas. in Control de las micotoxinas en la alimentacion humana. Memorias Reunion Cientifica, Publicacion INCAP CE/109: 57-61.

65. Riley RT, Norred WL, Voss KA, Sharma RP and Merrill AH Jr. (2000) Fumonisins - Occurrence, Toxicology and Mechanism of Action. Bulletin of the Institute of Comprehensive Agricultural Sciences (in press)

66. Merrill AH Jr & Schmelz E-M, Sphingolipids: Mechanism-based inhibitors of carcinogenesis produced by animals, plants and other organisms, in Handbook of Nutraceuticals and Functional Foods (R.E.C. Wildman, ed.) CRC Press, Boca Raton, Chapter 20

67. Merrill AH Jr & Schmelz E-M, Sullards, M. C.. & Dillehay, D. L., Sphingolipids: Novel inhibitors of colon carcinogenesis, Bulletin of the International Diary Federation 363: 27-29 (2001)

68. Linn SC, Him, HS, Keane EM, Andras LM, Wang E & Merrill AH Jr (2001) Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. Biochem. Soc. Trans. 29: 831-835

69. Merrill AH, Jr. & Sandhoff K (2002) Sphingolipids: metabolism and cell signaling. In: New Comprehensive Biochemistry: Biochemistry of Lipids,Lipoproteins,and Membranes (Vance DE &Vance JE eds) Elsevier Science Publ., Amsterdam, Chapter 14.

70. Smith WL, Merrill AH Jr. (2002) Sphingolipid metabolism and signaling minireview series. J Biol Chem. 2002 Jul 19;277(29):25841-2582.

71. Merrill AH, Jr (2002) De novo sphingolipid biosynthesis. A necessary, but dangerous, pathway. J. Biol. Chem. 277(29):25843-25846.

72. Desai, K, M. Cameron Sullards, Jeremy Allegood, Eva M. Schmelz, Michaela Hartl, Han-Ulrich Humpf, D. C. Liotta, Qiong Peng, and A. H. Merrill, Jr. (2002) Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis in Biochem. Biophys. Acta special issue: Lipids in Apoptosis (T. Levade, Y. Hannun and S. Spiegel, eds.) 1585:188-192

73. Leipelt, M & Merrill, AH Jr. (2004) Sphingolipid biosynthesis in Encyclopedia of Biological Chemistry (William Lennarz and M. Daniel Lane, Eds) Elsevier Science, San Diego, Chapter 13.

74. Marasas WF, Riley RT, Hendricks KA, Stevens VL, Sadler TW, Gelineau-Van Waes J, Missmer SA, Cabrera J, Torres O, Gelderblom WC, Allegood J, Martinez C, Maddox J, Miller JD, Starr L, Sullards MC, Roman AV, Voss KA, Wang E, Merrill AH Jr. (2004) Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo: A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize. J Nutr. 134:711-716.

75. Sullards MC and Merrill AH, Jr. (2005) Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) analysis of Sphingolipids in Lipidomics, in Functional Lipidomics (Li Feng & Glenn D. Prestwich, eds.) Marcel Dekker, Chapter 8


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76. Dennis EA, Brown HA, Deems RA, Glass CK, Merrill AH, Murphy RC, Raetz CRH, Shaw W, Subramaniam S, Russell D, VanNieuwenhze MS, White SH, Witztum JL, Wooley J. The LIPID MAPS Approach to Lipidomics. In: Functional Lipidomics (L Feng and GD Prestwich, eds), Marcel Dekker Inc., NY (in press).

77. Merrill AH, Jr., Sullards MC, Allegood JC, Kelly, S. and Wang, E. (2005) Sphingolipidomics: High-throughput, structure-specific and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry, Methods 36:207-224.

78. Fahy E, Subramaniam S, Brown HA, Glass C, Merrill AH Jr, Murphy R, Raetz CRH, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G., VanNieuwenhze MS, White SH, Witztum JL and Dennis EA (2005) A Comprehensive Classification System for Lipids, J. Lipid Res. 46:839-861

79. Wei J, Yerokun T, Liepelt M, Momin A, Wang E, Hanada K, and Merrill AH Jr (2006) Serine palmitoyltransferase, in Sphingolipid Biology (Hirabayashi, Igarashi and Merrill, eds.), Chapter 2.

80. Igarashi Y, Hirabayashi Y and Merrill AH Jr (2006) Overview-sphingolipid synthesis, transport and cellular signaling in Sphingolipid Biology (Hirabayashi, Igarashi and Merrill, eds.), Chapter 1.

81. Hong J, Allegood JC, Kelly S., Wang E, Merrill AH Jr and Wang MD (2006) Computer visualization model for the de novo sphingolipid biosynthetic pathway in Sphingolipid Biology (Hirabayashi, Igarashi and Merrill, eds.)

82. Curfman CL, Kirkland K, and Merrill, AH Jr. (2006) Recent anti-cancer agents targeting sphingolipid pathways, Expert Opinion on Therapeutic Patents, 16(8): 1129-1147.

83. Schmelz EM, Wang MD, and Merrill, AH Jr. (2006) Genomics, Proteomics, Metabolomics and Systems Biology Approaches to Nutrition, Present Knowledge in Nutrition, 9th edition, Chapter 1.

84. Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q, Ramaraju H, Sullards MC, Cabot M and Merrill AH Jr (2006) Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy, Biochim. Biophys. Acta 1758(12):1864-84.

85. Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH Jr, Murphy RC, Raetz CR, Russell DW, Subramaniam S. (2007) LMSD: LIPID MAPS structure database. Nucleic Acids Res. 2007 Jan;35(Database issue):D527-32.

86. Merrill AH Jr, Wang MD, Park M, Sullards MC (2008) (Glyco)Sphingolipidology: an amazing challenge and opportunity for systems biology, Trends Biochem. Sci. (2007) 32:457-68.

87. Sullards MC, Allegood JC, Kelly S, Wang E, Haynes CA, Chen Y, Shaner R and Merrill AH Jr. (2007) Structure-specific, quantitative methods for analysis of sphingolipids by liquid-chromatography tandem mass spectrometry: “Inside-out” sphingolipidomics in Methods in Enzymology (Alex Brown, ed.) 432:83-115.

88. Merrill AH Jr., Sphingolipids: diversity, metabolism, functions, and challenges for the “omics” era (2008) in Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (D. E. Vance and J. E. Vance, eds), Chapter 13.

89. Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH Jr. (2008) Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res. 49(8):1621-39.


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90. Merrill AH Jr, Stokes TH, Momin A, Park H, Portz BJ, Kelly S, Wang E, Sullards MC, Wang MD.(2009) Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease. J Lipid Res. 50: Suppl:S97-102.

91. Chen Y, Liu Y, Sullards MC, Merrill AH Jr (2010) An Introduction to Sphingolipid Metabolism and Analysis by New Technologies. Neuromolecular Med. 2010 Aug 3. [Epub ahead of print]PMID: 20680704 [PubMed - as supplied by publisher]Related citations

92. Chen Y, Liu Y, Allegood J, Wang E, Cachón-González B, Cox TM, Merrill AH Jr, Sullards MC. (2010) Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system. Methods Mol Biol. 2010;656:131-46.

93. Chen Y, Liu Y, Sullards MC, Merrill AH Jr. (2010) An introduction to sphingolipid metabolism and analysis by new technologies. Neuromolecular Med. 12:306-19. PMID: 20680704

94. Sullards MC, Liu Y, Chen Y, Merrill AH Jr. (2011) Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS/MS) and tissue imaging mass spectrometry (TIMS). Biochim Biophys Acta. 1811:838-53.PMID: 21749933

95. Merrill AH Jr. (2011) Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics, Chemical Reviews thematic issue on "Lipid Biochemistry, Metabolism and Signaling. Chem Rev. 111:6387-422. PMID 21942574

96. Murphy RC, Merrill AH Jr. (2011) Lipidomics and imaging mass spectrometry. Biochim Biophys Acta. 1811(11):635-6. Epub 2011 Sep 17. No abstract available. PMID 21983393

97. Abumrad NA, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CN. (2012) Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Adv Nutr. 3(1):60-8.

98. Merrill AH Jr, Murphy RC, Smith WL, Vance DE, Wilson JE, Yu RK. (2013) In memoriam: Charles (Chuck) Crawford Sweeley, Jr. (1930-2012). J Lipid Res. 54(1):1-4. PMID: 23367521.

99. Merrill AH, Dennis EA, McDonald JG, Fahy E. (2013) Lipidomics technologies at the end of the first decade and the beginning of the next. Adv Nutr. 4(5):565-7. doi: 10.3945/an.113.004333. PMID:24038259

Books: 1. Bell RM, Hannun YA & Merrill AH Jr (eds) (1993) Advances in Lipid Research:

Sphingolipids and Their Metabolites (Vol. 25) Academic Press, San Diego, CA 2. Bell RM, Hannun YA & Merrill AH Jr (eds) (1993) Advances in Lipid Research:

Sphingolipids and Their Metabolites (Vol. 26) Academic Press, San Diego, CA 3. Merrill AH Jr & Hannun YA (eds) (2000) Methods in Enzymology: Sphingolipid

Metabolism and Cell Signaling . Part A Vol. 311, Academic Press, San Diego, CA 4. Hannun YA & Merrill AH Jr (eds) (2000) Methods in Enzymology: Sphingolipid

Metabolism and Cell Signaling. Part B Vol. 312, Academic Press, San Diego, CA 5. Hirabayashi, Y., Igarahsi, Y., and Merrill, A. H., eds. Sphingolipid Biology (2006)

Springer, 304 p. Editor of Journal Special Edition: Robert Murphy (Univ. Colorado) and Al Merrill served as co-editors of a special edition of Biochim. Biophys. Acta on “Lipidomics and Tissue-Imaging


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Mass Spectrometry Technologies” published in 2011. Other publication categories (internet): 1. Sullards MC & Merrill AH Jr (2001) Analysis of Sphingosine 1-Phosphate, Ceramides and Other Bioactive Sphingolipids by Liquid Chromatography-Tandem Mass Spectrometry, Science Signal Transduction Environment (STKE) http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/67/pl1?ijkey=k2wc97k2AB1fU&keytype=ref&siteid=sigtrans 2. Merrill, AH Jr., Sullards, MC, Allegood, JC, Wang, E., Linn, SC, Andras, L., Liotta, DC, Hartl, M, and Humpf, H-U. (2002) Insights into the modulation of ceramide metabolism by naturally occurring and synthetic sphingolipid analogs as monitored by electrospray tandem mass spectrometry in Ceramide Signaling (A. H. Futerman, ed., Landes Bioscience Pub.) Chapter 3 (http://www.eurekah.com/). Website: www.sphingomap.org Patents: 1992 (May 5) US 5,110,987 Method of preparing sphingosine derivatives (with DC Liotta) 1993 (March 2) US 5,190,876 Method of modifying cellular differentiation and function and

compositions therefor (with JM Kinkade Jr & VL Stevens) 1993 (August 3) US 5,232,837 Method of altering sphingolipid metabolism and detecting

fumonisin ingestion and contamination (with RT Riley & E Wang) 1993 Internat’l Patent PCT/US92/06460 (pending) Method of altering sphingolipid

metabolism and detecting fumonisin ingestion and contamination (RT Riley & E Wang)

1995 US Patent 5,459,057, October (continuation of 5,190,876) 1999 US Patent 5,518,879, May 21 (expansion of 5,232,837) 1998 US Provisional Application no. 60/074,536 Sphingolipid derivatives and their

methods of use 2000 US Patent 6,127,578 Divisional of US5,232,837 2003 US Patent 6,552,025 Diimino-piperazine derivatives for use as modulators of

cell regulation 2003 United States Patent 6,610,835, August 26, 2003. Liotta; D. C.; Merrill,

A. H.; Keane; T. E.; Bhalla; K. N.; Schmelz; E. M. Sphingolipid derivatives and their methods of use.

2004 United States Patent 6,720,184, April 13, 2004.Merrill, A. H.; Wang; E. W.; Liotta; D. C.; Riley; R. T. Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination.

Submitted manuscripts: Several Research Grants and Contracts: Active:


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NIH/NIGMS GM069338 Lipid Maps Consortium (Ed Dennis PI) 9/01/03-8/31/2014 (NCE) Sphingolipid core (ca $300,000 per year) This “glue” grant will analyze all the lipids of macrophage cell lines and mouse macrophages under different states of activation. NIH 1R01GM076217 (Merrill, P.I.) 5/01/07-3/31/2016 Characterization of mammalian ceramide synthases Approx. direct costs requested: ($250,000 per year) The goal of this grant is to characterize the family of enzymes that are responsible for adding the N-acyl linked fatty acids of ceramide. This grant has identified the genes that code for ceramide synthases (CerS), studied regulation of expression of the mRNA/protein for the CerS, determined their biochemical properties, and is evaluating their roles in cell regulation and disease

Completed in the past 10 years: NIH R03 CA137812 (Merrill, P.I.) 7/01/09-6/30/2012 Chemoprevention via modulation of $100,000 total autophagy by sphingolipids The goal of this grant is to understand the regulation of this switch between “protective” and “lethal” autophagy in breast cancer cells via the induction of autophagy by dihydroceramide and accumulation of sphinganine. An underlying premise of this grant is that diet might affect dihydroceramide biosynthesis and induction of autophagy; therefore, the principles could be relevant to understanding the relationship between obesity and cancer. Memorial Sloan-Kettering Institute (subcontract under NCI grant to Gary Schwartz) 1/2005-07 Analysis of safingol pharmacokinetics in a phase I clinical [~$100,000] trial of safingol in solid tumors Dr. Schwartz is conducting one of the first human clinical trails of the sphingolipid analog safingol, and Dr. Merrill has developed an LC MS/MS assay to determine the blood concentrations of safingol and safingol metabolites in these patients NCI-U19-CA87525 (Merrill, P.I.) 7/01/00–6/30/07 Naturally occurring sphingolipids and sphingolipid analogs as mechanism-based anti-cancer agents [Approx $3,900,000]* The goal of this National Cooperative Drug Discovery Grant (NCDDG) is to develop new sphingolipid analogs for screening in in vitro and in vivo systems as potential cancer chemoprentive and chemotherapeutic agents. EmTech Biotechnology Development, Inc. 9/1/03-8/31/06 Cancer chemoprevention by sphingolipid-based pharmaceuticals $100,000 This grant tested the anti-cancer agent “Enigmol” for synergy or antagonism with other anti-cancer agents using human cancer cells in culture. Misc. Past Extramural Research Support (as P.I.):


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American Heart Association American Institute Cancer Research ILSI J & J Focused Giving Award M & M Mars NASA National Dairy Council NATO NCI, NIGMS and NIEHS grants (R01 and U19) NSF Office of Naval Research Pew National Foundation Faculty Fellowship Phillips Petroleum USDA (and as PI on NIDDK training grant for nutrition and health sciences doctoral program at Emory) Meetings and Symposia: As Chair or Vice Chair of the overall conference:

2000 Vice-Chair, Gordon Conference on Glycolipid and Sphingolipid Biology 2002 Chair, Gordon Conference on Glycolipid and Sphingolipid Biology

2007 Co-Chair (with Sarah Spiegel and Alex Brown), Keystone Conference on ‘Bioactive Lipids in the Lipidomics Era’

2007 Chair, Workshop on Lipidomics, EB2007, Washington, DC 2009 Chair, ASBMB Workshop on Lipidomics, EB2009, New Orleans 2013 Chair, ASN Workshop on Lipidomics, EB2013, Boston As Session Chair: 1988 Session Chair, Gordon Conference on Lipoproteins 1989 Chair, American Institute of Nutrition (AIN) Minisymposium: “Lipids and

Cancer” 1991 Chair, AIN Minisymposium, “Omega fatty acids and lipid metabolism” 1992 Chair, AIN Minisymposium, “Nutrition and second messenger systems” 1992 Session Chair: Gordon Conference on Sphingolipids 1992 Session Chair: Gordon Conference on Lipid Metabolism 1994 Chair, AIN Minisymposium “Nutritional modulation of lipid-mediated signal

transduction systems” FASEB, Anaheim 1995 Chair, AIN Minisymposium “Mycotoxins and Disease,” FASEB 1995 Chair, Colloquium: “Sphingolipids in Signal Transduction” International

Society for Neurochemistry, Kyoto, Japan (July) 1997 Chair, Sphingolipid session, Gordon Conference on Lipid Metabolism 1998 Session Chair, Gordon Conference on Sphingolipids and Disease Prevention

and Treatment 1999 Chair, ASNS Symposium at EB99 on “Mechanistic aspects of vitamin and


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coenzyme utilization and function” 2002 Chair, Session on Choline and Glycosphingolipids in Health and Disease,” 8th

International Congress on Phospholipids, Vienna, Austria 2003 Chair, Session on Sphingolipid metabolism and bioactive sphingolipids, 2nd

Charleston Ceramide Conference, Lake Cuomo, Italy 2004 Chair, Session on Sphingolipids in controlling cell behavior, Gordon

Conference on Glycolipid and Sphingolipid Biology, Japan 2005 Chair, Session on Sphingolipid Metabolism, Charleston Ceramide

Conferences (Charleston, South Carolina) 2006 Chair, Session on Sphingolipidomics, Gordon Research Conference on

Glycolipids and Sphingolipids, Ventura, CA 2006 Co-chair, Session on Lipidomics, From Proteomics to Lipidomics - Basics,

Advances and Applications" in Bonn 2008 Session chair, Gordon Conference on Glycolipids and Sphingolipids (was

unable to attend due to health complications) 2008 Session chair for Sphingolipidomics, “Worldwide Advances in Lipidomics,

5th Annual LIPID MAPS Meeting, San Diego 2009 Session chair for Sphingolipidomics, Charleston Ceramide Conference,

Charleston, S.C. 2010 Session chair for Sphingolipidomics and Model Systems, Gordon Conference

on Glycolipids and Sphingolipids, Ventura, CA 2012 Session chair on new technologies, Gordon Conference on Glycolipids and

Sphingolipids, Il Coco, Italy 2014 Session chair for Gordon Research Conference on Sphingolipids, Ventura, CA As speaker (2000-2013) (all invited): 1. FDA Symposium on Fumonisins, “Sphingolipid Metabolism and Cell Signaling:

Perturbation by fumonisins: Structure-activity relationships for sphingolipids and sphingolipid analogs, with particular reference to fumonisins,” Univ. Maryland

2. Keystone Conference, “Cell Processes Affected by Sphingolipid Signaling,” Taos, NM 3. Symposium on Model Systems for Diet and Cancer Studies, Experimental Biology 2000,

“Sphingolipids as chemopreventive/chemotherapeutic agents in colon cancer,” San Diego, CA

4. Glycolipid and Sphingolipid Gordon Conference, “Regulation of de novo sphingolipid biosynthesis,” Il Coccio, Italy

5. Nutrition Week 2000, “Sphingolipids: Novel inhibitors of colon carcinogenesis,” Dublin, Ireland

6. FASEB Summer Conference on Lipid Digestion, “Sphingolipid signaling and the prevention of colon tumorigenesis,” Vermont Academy, Saxons River, VT

7. Balkan Summer Conference, “Sphingolipids—the enigmatic lipid class: Biochemistry, physiology and pathophysiology,” Kiel, Germany

8. Southeastern Lipid Conference, “Cell signaling by sphingolipids: A new paradigm for understanding relationships between diet and cancer as well as development of mechanism-based anti-cancer agents ,” Cashiers, NC


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9. EB2001: 2 symposia presentations (ASPET, ASNS) 10. Biochemical Society, 2001: "De novo sphingolipid biosynthesis: A necessary but

dangerous pathway," Dublin, Ireland 11. International Phospholipid Society, 2002, “Sphingolipid structures, metabolism and

function--nutritional implications for disease”, Vienna, Austria 12. Charleston Ceramide Conference, 2003 (Lake Como, Italy) 13. Hokkaido Sphingolipid Conferences, 2004: “The Lipid Maps Consortium and its strategy

for “sphingolipidomics” (Sapporo, Japan) 14. Glycolipid and Sphingolipid Gordon Conference, 2004: “Sphingolipids in Controlling Cell

Function (SpRing8, Japan) 15. Charleston Ceramide Conference, 2005: “Characterization & Regulation of De novo

Ceramide Synthesis” (Charleston, SC) 16. EB 2005, ASPET Workshop on Lipid Methodologies: “Sphingolipid Metabolism: (San

Diego, CA) 17. Mass Spectrometry Workshop on Lipidomics: “Quantitative analysis of sphingolipids”

(Dresden, Germany) 18. NIGMS Glue Grant Meeting: “Standardization and quality control in “omic’ analysis”

(Bethesda, MD), May 2005 19. Glycolipid and Sphingolipid Gordon Conference, January 2006: “Sphingolipidomics” 20. EB 2006, ASBMB Lipidomics Symposium Speaker (April, 2006) 21. Metabolomics SocietyL “New Methods for Analysis and Visualization of the

Sphingolipidome” (Boston, June, 2006) 22. Proteomics and Lipidomics Conference: “Liquid chromatographic mass spectrometric

analysis of sphingolipids and some surprising findings from its application” (Bonn, July, 2006)

23. NIH Glycomics Workshop: Glycosphingolipid analysis and visualization (Bethesda, September, 2006)

24. The Sphingolipid Club: “Bioactive sphingolipids in health and disease: lipidomic analysis, metabolism and roles in membrane signaling and autophagy” (Barcelona Spain, November, 2006)

25. FASEB Conference on Lysophospholipids: “Sphingolipids and cancer: Just when things were appearing simple, along came autophagy” (June, 2007)

26. “Worldwide Advances in Lipidomics,” 5th Annual LIPID MAPS Meeting (May, 2008), San Diego; title: “Sphingolipid biosynthesis in RAW 264.7 cells”

27. Keynote address, Georgia State University “Molecular Basis of Disease Research Day,” Atlanta, May, 2008; title: “Gen-omics, prote-omics, glyc-omics, and now lipid-omics: Challenges, approaches and promises from one of the newest “omics”

27. AACR Frontiers in Cancer Prevention Research: “Sphingolipid biodiversity and cancer: an endless source of surprises in cell regulation and novel strategies for cancer chemoprevention and chemotherapy ,” November 16, 2008

28. ASMS Symposium on Lipidomic Technologies, January, 2009. 29. Third Singapore Lipid Symposium, March 2010, title: “LIPID MAPS lipidomics

technologies for sphingolipids and their application to inflammation and disease” 30. Lipid Maps Annual Meeting May 2010: “Lipidomics: Impact on cell biology,

atherosclerosis, and inflammatory disease,” Title: Nuclear sphingolipids and nuclear receptors for sphingolipids.”


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31. 27th Naito Conference: Membrane Dynamics and Lipid Biology, June/July 2010, Sapporo, Japan; Title: Navigating the lipid map: New technologies and surprising findings about sphingolipid biology and disease

32. 51st International Conference on the Bioscience of Lipids, September 7-11, 2010, Bilbao, Spain; Title: Regulation of sphingolipid biosynthesis de novo by novel mechanisms of substrate supply and membrane trafficking

33. ILSI Symposium on Functional Foods for Health Promotion: Moving Beyond “Good Fat, Bad Fat” – the Complex Roles of Dietary Lipids in Cellular Function and Health (EB2011), April 9, 2011, Washington DC; Title: "Effects of diet and other factors on brain sphingolipids and neuronal function"

34. Gordon Research Conference the Molecular & Cellular Biology of Lipids, July 17-22, 2011, Waterville Valley Resort, Waterville Valley, NH; Title: Novel Methodologies and Lipid Frontiers

35. FASEB Conference on Phospholipid Metabolism: Disease, Signal Transduction, and Membrane Dynamics, July 15-20, 2012, Vermont Academy, Saxton’s River, VT (title not yet chosen)

36. FASEB Conference on Bioactive Lipids (Japan) (2013) 37. Gordon Research Conference on Sphingolipids and Glycolipids (2014) Seminars at other institutions: Atherogenics Auburn University Clark-Atlanta University Clemson University Columbia University Cornell University Dartmouth University Duke University E. Carolina University Medical School Emory University Epley Institute for Cancer Research (University of Nebraska, Omaha) Food & Drug Administration Geltex, Inc. Georgia State University Georgia Tech Gifu University Hoechst Pharmaceuticals Hoffman-La Roche Labs INCAP (Guatemala) Iowa State University Kyoto University Lilly Pharmaceuticals LPath Pharmaceuticals Mead-Johnson Labs Medical College of Georgia Medical University of South Carolina (Charleston)


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Memorial Sloan-Kettering Cancer Center (NYC) Mercer University Merck, Sharp & Dohm Labs Michigan State University Monsanto (St. Louis) Moscow Institute of Nutrition NASA (Ames, CA and Houston, TX) National Cancer Inst. (NIH) Neose Pharmaceuticals Pfizer Pharmaceuticals Phillips Petroleum (Biotechnol. Div) Purdue University Rice University Rutgers University R. W. Johnson Pharmaceutical Research Institute Spelman College Sphinx, Inc. SUNY (Stony Brook) SUNY (Queens College) Texas A&M University Tokai University (Japan) Tufts University University of Alabama University of Alberta University of Arizona University of Bonn (Germany) University of California, Berkeley University of California, Davis University of California, Los Angeles (UCLA) University of Cincinnati College of Medicine University of Florida University of Georgia University of Illinois (Champagne-Urbana) University of Illinois (Chicago) University of Kentucky University of Miami University of Missouri (Columbia) University of Nebraska (Lincoln) University of North Carolina, Chapel Hill University of Perugia (ICBL, Italy) University of Texas Southwestern (Dallas) University of Virginia Universitaet Wurtzburg (Germany) U. S. Centers for Disease Control and Prevention (Atlanta) USDA Mycotoxins Res. Labs (Athens, GA and Peoria IL) Vanderbilt University


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Virginia Commonwealth University Virginia Tech Wake Forest University Williams College (MA) Committees - Georgia Tech: 2001-05 Member, School of Biology Search Committee for Asst./Assoc. Prof. in

Molecular Biology 2001- Executive Committee for the Petit Inst. for Bioengineering & Biosciences 2002-04 Member, Search Committee for Chair, School of Biology 2002-04 Chair, Georgia Tech Cancer Research Council Executive Committee 2004-07 Chair, Promotions and Tenure Committee, School of Biology 2006 Chair, Search Committee for faculty in Developmental Cell Biology 2006 Co-Chair, Search Committee for Dean of College of Sciences, Georgia Tech 2007- Chair, Georgia Tech Biological Materials Safeguards Committee Member, Institute Council on Environmental Health and Safety 2007-2010 College of Sciences Promotion and Tenure Committee 2008 Search Committee for Chair of Chemistry and Biochemistry Search

Committee 2009-2010 Chair, Search Committee for School of Biology Assistant Professor Committee Memberships-National/International: 1981 Ad hoc member, NIH study section, “Mechanism of chemical and biological

prevention of cancer” 1985-92 Grants Review Panel, American Institute for Cancer Research 1986-91 Member, Metabolic Pathology Review Group (NIH) 1996-99 Member, Long-Range Planning Committee, ASNS 1997-00 Member, External Advisory Comm., Division of Nutritional Sciences,

University of Illinois, Urbana-Champaign 1997-00 Member, FASEB Research Conferences Advisory Committee 1997-01 Chair, External Advisory Committee, Research Infrastructure for Minority

Institutions (RIMI) Program, Spelman College, Atlanta 1998 Member, ASNS Council 1998-01 Chair, External Advisory Committee, Life Sciences Research Office (LSRO),

ASNS 1999-02 ASNS Representative to FASEB Board 1999-01 Member, Food and Nutrition Board, Institute of Medicine (Co-Vice Chair,

2000-01) 2000-02 Member, Advisory Committee for the Instituto de Nutricion de Centroamerica

y Panama (INCAP/OPS), Guatemala 2000-02 Member, Executive Committee, Diet and Cancer Research Interest Group,

ASNS 2002-03 Vice-President for Science Policy (Elect), Federation of American Societies

for Experimental Biology (FASEB) 2004 Ad hoc member, NIH special study sections for METABOLOMICS

TECHNOLOGY DEVELOPMENT and Basic Mechanisms of Cancer


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Therapeutics 2004 Chair, Nominating Committee for the Osborne and Mendel Award, the

American Society for Nutritional Sciences 2005 Ad hoc member, NIH special study section: Basic Mechanisms of Cancer

Therapeutics 2006-present Additional ad hoc grant review committees 2009-present Chair of the Outreach committee of the LIPID MAPS Consortium 2012-present Member of the Advisory Board of the Washington University NIH

Research Resource for Mass Spectrometry Editorships and Editorial Boards: 1988-96 Contributing Editor, Nutrition Reviews 1989-96 Associate Editor, The Journal of Nutrition 1989-94 Editorial Board, The Journal of Biological Chemistry 1995-00 Editorial Board, Biochimica Biophysica Acta 1996-00 Editorial Board, The Journal of Biological Chemistry 1998-06 Editorial Advisory Board, Present Knowledge in Nutrition , (8th ed.), ILSI 2000-04 Member, Advisory Board, The Journal of Biochemistry (Tokyo) 2003-08 Editorial Board, The Journal of Biological Chemistry (third term) 2004- Editorial Board (Senior Editor), Molecular Nutrition & Food Research 2004-09 Editorial Board, The Journal of Lipid Research (second term) 2008- Editorial Board, Biochimica Biophysica Acta (second term) 2009- Associate Editor, The Journal of Lipid Research 2012- Editorial Board, The Journal of Biological Chemistry (fourth term) Former Committee Memberships-Emory University: 1983-89 Nutrition and Cancer Advis. Comm., Winship Cancer Service Center 1984-89 Evening at Emory: “The Chemistry of Life: The Inside Story” 1986-87 Evening at Emory: “Diet and Cancer” 1986-93 Clinical Research Facility Advisory Committee 1987-89 Medical School Admissions Committee 1987-00 Co-Director, Metro-Atlanta Nutrition Association (MANA) 1990-92 Graduate School Executive Committee 1990-92 Medical School Curriculum Committee 1990-91 Chair, Nutr. & Cancer Adv. Comm. Winship Cancer Center 1993-99 Medical Student Research Day Committee 1994-95 Graduate School Governance Committee 1994-97 Graduate School Advisory Council 1994 Search Committee: Graduate School Dean 1994-96 Winship Cancer Center Advisory Committee 1994-98 Problem-Based Learning Course (medical students) 1995 Emory Committee to Review Conflict of Interest 1995 Lecturer, “Ethics in Science” course 1995-96 Chair, Search Comm.: Eminent Scholar in X-ray Crystallography 1995-96 Search Committee: Chair, Anatomy & Cell Biology 1996-97 Member, Commission on Teaching; Chair, Awards and Incentives Sub-


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Committee 1997 Co-Chair, Emory-Industry Relations Sub-Committee, Strategic Planning

Committee 1998 Member, Strategic Planning Committee on Teaching in the School of

Medicine 1999-01 Member, Executive Committee, Nutrition & Health Sciences Graduate 2000-01 Member, Board of Advisors for the Emory Center for Ethics in Public Policy

and the Professions Honors, Awards, and Recognitions: 1972 Phi Lambda Upsilon Award, Virginia Tech 1976 DuPont Award for teaching, Cornell University 1979 American Institute of Nutrition Graduate Student Research Award 1985 Emory Williams Teaching Award for Natural Sciences 1989 American Institute of Nutrition, Mead Johnson Award, for major research

contributions to nutrition before age 40 1989-92 Pew Faculty Scholar in Nutrition 1990 Outstanding Teacher of Biochem., Emory Medical Class of 1993 1990,91 Cosmos 1884 & 2044 Achievement Awards, NASA 1991-92 Visiting Professor in Nutrition, National Dairy Council 1992 Boyd O’Dell Lecturer, U. Missouri, Columbia, MO 1996 Osborne and Mendel Award for Basic Research Accomplishments in

Nutrition 1997 Visiting Professor in Nutrition, National Dairy Council

2000 AAAS Fellow 2000 Designated “Surveyor of the Karst Terraine, Order of the Golden Compass”

by The Southeastern Cave Conservancy, Inc. 2002 Chair, Gordon Conference on Glycolipid and Sphingolipid Biology 2009 Sustained Research Award, Georgia Tech chapter of Sigma Xi 2010 Georgia Tech College of Sciences Faculty Mentor Award 2012 Georgia Tech Class of 1934 Course Survey Teaching Effectiveness Award

Membership in Professional and Honor Societies (current): American Association for the Advancement of Science (AAAS) American Association for Cancer Research (AACR) American Chemical Society (ACS) American Society for Biochemistry and Molecular (ASBMB) American Society for Mass Spectroscopy (ASMS) American Society for Nutrition (ASN) International Society of Arachnology (ISA) Graduate and Undergraduate Students Supervised: Graduate students: Dates Student Degree/Institution Current Position


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1982-84 Williams, R.D. MS (1984) Emory Dept. Pathol., PhD (1987) Emory University Ohio State 1982-88 Innis-Whitehouse, W. PhD (1988) Emory Assistant Prof. Univ. Texas Pan-Amer. 1983-88 Stevens, V.L. PhD (1988) Emory American Cancer Soc. 1985-88 Medlock, K.A. MS Biochemistry (1988) Emory Crockett Hospital (now Goodemote) MD (1997) Georgetown Loretto, TN 1988 Sikkema-Burnham, F. MS Nutrition (1987-88) Emory Research technician 1988-90 Moorwessel, M. MS Nutrition (1990) Emory Nutritionist, Grady Hosp. Atlanta, GA 1988-94 Smith, E.R. PhD (1994) Emory Res. Scientist, Univ. Miami 1994 Zacharias, C. (3 mos) PhD (1995) U. Bonn, Germany German Pharmaceut. 1995 Vales, T. MS (1995) Emory Res. Spec., GA Tech 1998 Calligan, B. MS (May 1999) Res. Tech., Novartis 1999 Desai, K. MS (2002) Med School/Residency 2000 Hartl, M. (3 mos) Ph.D. (2000) U. Wurtzurg, Ger. Practicing physician 2000 Keane, E. B. MS (2002) High School teacher 2000 Symolon, H. PhD (2006) Coca-Cola 2001 Pruett, S. PhD (primary: Dennis Liotta) Yerkes 2002 Momin, A. PhD (bioinformatics)(2010) post doc MD Anderson 2003 Haynes, C. PhD (2010) CDC, Atlanta 2003 Zheng, W. MS (2006) NYC venture capital firm 2003 Allegood, J. PhD (2008) Post-doc VCU 2004 Liu, Y. PhD (2010) Post-doc Emory University 2004 Wei, J. PhD (2009) Post-doc Scripps,San Diego 2004 Kollmeyer, J. MS (2006) Res. Tech. U. Michigan 2005 Park, H. Ph.D. (2009) Post-doc at Boston U. 2006 Sims (Kirckland), K. Ph.D. (2011) Avanti Polar Lipids 2007 Shaner, R. M.S. (2010) Res. Tech. CDC 2012 Bame, J. M.S. (2013) Grad. School in England Undergraduate students: Coleman Binford Regina LaRocque Mary Miller Radhu Reddy Gary Shapira Jennifer Saarinen K. Dyer Janet Ou (Hughes Scholar) Katie Peters (Hughes Undergraduate Fellow) Andrew L. Kau (Hughes Undergraduate Fellow) J. Hearn Jeremy Allegood


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Lindsay Andras Will Weldon Saudiqua. Hoossainy M. Patel Kara Boltz K. Keane Madu Adiga Jessica Kollmeyer Chad Chirich Elizabeth Munter Carrie Davis Pack Jessica Jopeck Brett Fields Leslie Jones Chung Fung Hsu Kristine Uyesugi Anu Koppikar Meeyoung Park Harsha Ramarada Brianna Burgess Katie Fluke Catherine Park Jessica Valente Adeeb Zaer Saumya Dave Humera Chaudhary Rebecca Lee Brent Portz Laura Calvo John Bowen Kristen Jones Jennifer Knotts Courtney Fox Sarah Singh Cait McNamara Cristine Amuzie Courtney Widjaja Jennifer Lee Michelle Vu Andrew Warren Abhi Goswami Akwasi Aduboffour Kayla A. Carter Pureum Kim


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Other (Medical students at Emory): M.A. Codner (1985 Dean’s Award for Outstanding Research by Medical Student) M. Hoel B.W. McDonald J. Cochran, S. Surowiec (These 2 chosen to present talks for 1992 Medical Student

Research Day; Surowiec winner of Helen Miller Award for Most Outstanding and Meritorious Research Project by Medical Student.)

Charles Trey Perkins Postdoctoral Fellows Supervised: 1984-85 Yanish, M.A. MD (1984) Emory U. Tex. Hlth. Sci. Ctr. 1985-86 Messmer, T.O. PhD (1984) Salk Institute Res. Scientist, CDC 1988-89 Jones, D.D. PhD (1988) U. Georgia CDC, Nutr. Division 1990-95 Schroeder, J.J. PhD (1990) U. Florida. Asst Prof Mich. St. 1992-98 Schmelz, E-M. PhD (1993) U. Geissen Asst Prof Biochem, Germany Wayne State U. 1992-98 Nikolova-Karakashian, M Assoc Prof PhD (1992) Bulgarian Acad. Sci U Kentucky 1994-95 Kok, J. W. U. Groningen Assoc. Prof. Groningen 1996-97 Vesper, H Technical U., Munich, Germany Res. Sci., CDC 1997 Humpf, H-U. PhD, U. Wurzberg, Germany Asst. Prof., Wurzburg 1997-98 Stewart, J. PhD, Clark-Atlanta U. Visiting Prof 1997-98 Kim, H-S. PhD , U. Kyungsung, Korea Visiting Prof 1997-00 Sullards, C. PhD (1997) Emory (Chemistry) Prof, Ga Tech 1998-02 Linn, S. PhD , U. Cincinnatti Asst. Prof. Univ. Dallas 2001-04 Yerokun, T. PhD, Morehouse Res. Assoc., Clark At 2000-95 Peng, Q. MD/PhD (1998), Res. Assoc., Emory Peking Union Med. Post-doctoral fellow College & Chinese Acad. Med. Sci. 2002-05 Leipelt, M. PhD, Hamburg Medical practice 2006- Chen, Yanfeng PhD, Georgia Tech CDC (joint with M.C. Sullards) 2007-2008 Lioa, Lijian PhD, Bowling Green State Univ. Scripps 2007-2008 Lee, Soojung PhD, Kyungsung University Post-doc Emory 2009-2012 Bandyopadhyay, Sibali PhD, Univ. of Georgia Res. Assoc., U. Miss. 2012- Duan, Jingjing PhD., Kyoto University, Japan

curriculum vitae merrill, alfred h., jr. professor and ... · 2/24/2014 · curriculum vitae...

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