curriculum vitae michaela jansen, pharm.d., ph.d ...cv / michaela jansen, ph.d. 2/21 academic...

CV/MichaelaJansen,Ph.D. 1/21

CURRICULUMVITAE

June,2017

Michaela Jansen, Pharm.D., Ph.D. Associate Professor with Academic Tenure DepartmentofCellPhysiologyandMolecularBiophysicsCenterforMembraneProteinResearchTexasTechUniversityHealthSciencesCenter36014thStreet,Room5A172Lubbock,TX79430-6551,USAPhone:+18067434059FAX:+18067431512;Email:[email protected]

Education • Ph.D.(Dr.rer.nat.)MedicinalChemistry

(summacumlaude),JohannesGutenberg-University,Mainz,Germany.

2001

• Pharm.D.(Pharmacydegree,“Approbation”),JohannesGutenberg-University,Mainz,Germany.

1997

Training • Studiedmembraneproteinstructurefunctioninterplayunderthe

directionofProf.M.H.Akabas,Dept.ofPhysiologyandBiophysics,AlbertEinsteinCollegeofMedicine,NewYork,USA.

2003–2008

• Researchonligandsforpentamericligand-gatedionchannelsunderthedirectionofProf.G.Dannhardt,Dept.ofMedicinalandPharmaceuticalChemistry,JohannesGutenberg-University,Mainz,Germany.

2001–2003

• Development,synthesisandpharmacologicstudiesofligandsforligand-gatedionchannelsunderProf.G.Dannhardt,Dept.ofMedicinalandPharmaceuticalChemistry,JohannesGutenberg-University,Mainz,Germany.Completeddissertationentitled“AntagonistsoftheGlycinebindingsiteoftheNMDAreceptor”.

1992–1997 – Nov.2001

• PostgraduateResearch,InstituteofNuclearChemistry,PositronEmissionTomography(PET)Center,JohannesGutenberg-University,Mainz,Germany.

1996–1997

• Pre-registrationtraining,HospitalPharmacyoftheJohannesGutenberg-UniversityandMercatorPharmacy,Mainz,Germany.

1996–1997


Academic Appointments

Texas Tech University Health Sciences Center, Lubbock, TX DEPARTMENTOFCELLPHYSIOLOGYANDMOLECULARBIOPHYSICS• AssociateProfessor Sept2015–Present• AcademicTenure Mar2015 –Present• AssistantProfessor Dec2008 –Aug2015• CenterforMembraneProteinResearch,Member 2008–Present• GraduateSchoolforBiomedicalSciences,Member 2008–Present• PhysiologyGraduateFacultywithinGraduateSchoolof

BiomedicalSciences(GSBS),PrimaryAppt.2008–Present

• BiotechnologyGraduateFacultywithinGSBS,JointAppt. 2009–Present• PharmacologyandNeuroscienceGraduateFacultywithin

GSBS,AssociateAppt.2011–Present

Awards and Fellowships • President’sYoungInvestigatorAward,TTUHSC. 2014• ParticipantandStipendfortheAssociationofAmericanMedical

Collegescourse,EarlyCareerWomenFacultyProfessionalDevelopmentSeminar,providedbyTTUHSCSOMDean’sOfficeandDepartmentofCellPhysiologyandMolecularBiophysics,TTUHSC.

2014

• Dean’sUnsungHeroAward,NominatedbyChair(LuisReuss,M.D.)ofDepartmentofCellPhysiologyandMolecularBiophysics,TTUHSC.

2013

• FellowshipfortheGermanScholarsOrganization“BuildingBridges”Meeting,Berlin,Germany.

2011

• NIHPathwaytoIndependenceAward(R00),NicotinicAcetylcholineReceptorStructure,ThermalMotionandGating

2008

• FellowshipfortheLindauNobelLaureateMeetinginPhysiologyandMedicine2007,GermanAcademicExchangeService(DAAD)andGermanAcademicInternationalNetwork(GAIN),Lindau,Germany.

2007

• NIHPathwaytoIndependenceAward(K99),NicotinicAcetylcholineReceptorStructure,ThermalMotionandGating.

2007

• OutstandingPostdoctoralResearchScholarAward,BelferInstituteforAdvancedBiomedicalStudies,AlbertEinsteinCollegeofMedicine,NewYork,USA.

2006

• FellowshipforAnnualMeetingofGermanYoungScientistsinNorthAmerica,GermanAcademicInternationalNetwork(GAIN),September17-18th,Boston.

2004

• ResearchFellowship,GermanResearchFoundation(DFGStipendium,18months),Germany,forpostdoctoralresearchattheAlbertEinsteinCollegeofMedicine,NewYork,USA;DevelopmentofNewSubtype-SelectiveGABA-Mimetics–InvestigationoftheBindingSiteandSignalTransduction.

2003–2005

• Dissertation-AwardoftheJohannesGutenberg-University,Mainz,Germany.NamedbytheDepartmentofChemistryandPharmacy.

2002


Grant Support as Principal Investigator (Total direct costs $2,217,892) • CenterofExcellenceforTranslationalNeuroscienceand

Therapeutics(CTNT),PN-CTNT2016-09MJDS,RoleofNicotineModulationofnAChR-α7ReceptorsandRIC-3inMonocytes/MacrophagesforFutureTherapeuticUseDuringSepsis(Co-Is:SharmilaDissanaike),$30,000(directcosts)matchedwith$10,000byCPMBandsurgerydepartment($5,000,each).

09/2016–08/2017

• LauraW.BushInstituteforWomen’sHealth&UMCHealthSystem,FolateTransporterinPregnancyandCancer(Co-Is:InaUrbatsch,GuillermoAltenberg),$10,000(directcosts)matchedwith$10,000byCPMBdepartment.

05/2016–04/2017

• CenterforMembraneProteinResearchCollaborativeGrant,TTUHSC,FunctionalOverexpressionofthehumanProton-CoupledFolateTransporterinYeast(Co-PI:UrbatschI),$35,000(directcosts).

10/2014–08/2015

• SouthPlainsFoundation(SPF),IdentificationoftheMolecularTargetoftheAntidepressant/SmokingCessationDrugBupropionwithSerotoninType3Receptors(Co-PIs:BlantonM,WilmsH),$15,000(directcosts).

09/2014–08/2015

• CHFoundation,IdentificationofTherapeuticTargetsforNeurologicalDiseasesandCancertoImproveTreatment,$66,300(directcosts).

12/2014–11/2015

• NINDS/NIHR01,1R01NS077114-01A1,ProbingtheStructureandFunctionoftheIntracellularDomainofCys-LoopReceptors(Co-Is:CuelloLG,ArtigasP),$1,093,750(directcosts).

04/2014–03/2019

• TTUHSCOfficeofResearch,PreliminaryDataGrantProgram,MolecularMechanismofTransportofFolatesandAntifolatesbyPCFT(Co-I:BlantonMP),$19,598(directcosts).

01/2012–12/2013

• SouthPlainsFoundation(SPF),FunctionalStudiesofNeuronalReceptorChimeras,$15,000(directcosts).

09/2012–08/2013

• CenterforMembraneProteinResearchCollaborativeGrant,TTUHSC,ChimeraStudiesoftheIntracellularDomainofCys-LoopReceptors(Co-PI:CuelloLG),$32,500(directcosts).

09/2012–08/2013

• CenterforMembraneProteinResearchCollaborativeGrant,TTUHSC,ExpressionandPurificationofthehumanProton-CoupledFolateTransporter(Co-PIs:BlantonM,GuanL),$65,000(directcosts).

05/2011–04/2012

• SouthPlainsFoundation(SPF),NovelDrugDiscovery:PositiveAllostericModulatorsoftheα7NicotinicAcetylcholineReceptor(Co-PI:BlantonM),$15,000(directcosts).

09/2010–08/2011

• SouthPlainsFoundation(SPF),StructureFunctionStudiesoftheIntracellularDomainofCys-LoopReceptors,$15,000(directcosts).

09/2009–08/2010

• CenterforMembraneProteinResearchCollaborativeGrant,TTUHSC,StructureandFunctionStudiesofProtonCoupledFolateTransporters(Co-PI:BlantonM).$65,000(directcosts).

05/2009–04/2010

• NINDS/NIHPathwaytoIndependenceAward(R00),R00NS059841,NicotinicAcetylcholineReceptorStructure,ThermalMotionandGating,$495,578(directcosts).

12/2008–11/2012


• NINDS/NIHPathwaytoIndependenceAward(K99),K99NS059841, NicotinicAcetylcholineReceptorStructure,ThermalMotionandGating,$166,666(directcosts).

09/2007–11/2008

• GermanResearchFoundation(DFG),Germany,DFGJA1081/1-1,PostdoctoralResearchStipendforresearchattheAlbertEinsteinCollegeofMedicine,NewYork,USA,DevelopmentofNewSubtype-SelectiveGABA-Mimetics–InvestigationoftheBindingSiteandSignalTransduction,€35,100=$50,500(directcosts).

10/2003–03/2005

• Researchfund(Forschungsfond2003),JohannesGutenberg-University,Mainz,Germany,DevelopmentandTestingofInnovativeGABAAMimeticswithReceptor-SubtypeSelectivity,€12,500=$18,000(directcosts).

2003

Grant Review Committees • NationalInstitutesofHealth(NIH),BiophysicsofNeuralSystemStudySection,BPNS,Ad-

hocmember,2016/31–2017/02.• AmericanHeartAssociation(AHA),Proteins&Crystallography2,October2015-present• NationalInstitutesofHealth(NIH),MolecularNeuroscienceStudySection,ZRG1MDCN-N

(04),Ad-hocmemberforspecialpanel,2012/04.

Referee for Scientific Journals • ACSChemicalNeuroscience,Elsevier,2010–present• AmericanJournalofPhysiology–CellPhysiology,2014–present• BiochemicalJournal,PortlandPress,2010–present• BiochemicalPharmacology,Elsevier,2005–present• Biochemistry,ACS,2013-present• BioorganicandMedicinalChemistry,Elsevier,2006–present• BiophysicalJournal,BiophysicalSociety,2011–present• BrainResearch,Elsevier,2015–present• CurrentDrugTargets,BenthamSciencePublishersLtd.,2010–present• CurrentTopicsinMedicinalChemistry,BenthamSciencePublishersLtd.,2005–present• JournalofMedicinalChemistry,ACS,2006–present• JournalofBiologicalChemistry,Highwire,2010–present• JournalofNeurochemistry,Wiley,2013–present• MolecularNeurobiology,Springer,2012–present• Neuropharmacology,Elsevier,2014–present• ProteinScience,Wiley,2014–present• ScientificReports,NaturePublishingGroup,2016–present• Structure,Cell,2016–present

Professorship Offers / List Rankings • OfferedpositionasProfessorExtraordinarius,TransCureProfessorshipinBiopharmacy,

UniversityofBern,Switzerland,declined,10/2011.

Membership in Professional Societies • AmericanChemicalSociety,USA,2013–present• BiophysicalSociety,USA,2007-present• GermanPharmaceuticalSociety,Germany,2000–present• NewYorkAcademyofSciences,USA,2005-present• SocietyforNeuroscience,USA,2005–present


Professional Activities / Institutional Service

TTUHSC, Lubbock, TX, USA AsAssociateProfessor

• Chair,FacultySearchCommittee,DepartmentofCellPhysiologyandMolecularBiophysics.

10/2016 –present

• GraduateAdvisor,MolecularBiophysicsConcentration,GSBS. 08/2016 –present• Vice-Chair,FacultyCommitteeonClinicalandResearchInformation

Technology(FCCRIT).01/2016 –present

• TTUHSCSOMFacultyCouncilExecutiveCommittee(FCEC),Chair.Member,ELECTED2014and2017for3-yearterm,each.Chair-Elect,ELECTED2014.Chair,FacultyForwardTaskForce–FacultyPromotionandRetention.Member,FacultyForwardTaskForce–FacultyScholarship.

09/2015 –08/201609/2014 –08/202009/2014 –08/201510/2014 –08/201510/2014 –08/2015

• Senator,TTUHSCFacultySenate. 09/2014–08/2017• Member,TTUHSCSOMTenureandPromotionCommittee. 09/2015 –present• Presenter,NIHGraduate&ProfessionalSchoolFair,Natcher

ConferenceCenter,NIH,Bethesda,Maryland,2016,2017.06/2015 –06/2016

• Member,Sex-andGender-BasedMedicine(SGBM)SymposiumPlanningCommittee,TTUHSCOfficeoftheProvostandLauraW.BushInstituteforWomen'sHealth.

05/2013 –11/2014

• Member,TTUHSCSOMMedicalStudentsAdmissionsCommittee. 09/2010 –present• Member,GSBSAdmissionsCommittee. 02/2014 –present• Member,GSBSGraduateCouncil,2011-2013,2013-2015,2015-

2017.09/2011 –present

• Member,RecruitmentAdvisoryCommittee,DepartmentofCellPhysiologyandMolecularBiophysics.

06/2015 –present

• AssistanttoGraduateAdvisor,DepartmentofCellPhysiologyandMolecularBiophysics.

09/2011 –06/2016

• FounderandOrganizer,MemBRAINYClub(JournalClubandWorkinProgress)oftheDepartmentofCellPhysiologyandMolecularBiophysics.

09/2011 –present

• Presenter,FCEC,NewFacultyOrientation,TTUHSCSOM 09/2015

AsAssistantProfessor• Member,GSBSOutstandingGraduateStudentandDean’sAward

Committee.04/2015

• Member,RecruitmentAdvisoryCommittee,DepartmentofCellPhysiologyandMolecularBiophysics.

06/2015 –08/2015

• Member,SelectionCommitteeRecruitmentScholarships,GSBS. 03/2015 –08/2015• Member,InternalProgramReviewCommittee,GSBSProgram

Review,Biotechnology.09/2014 –02/2015

• Senator,TTUHSCFacultySenate. 09/2014 –08/2017


• TTUHSCSOMFacultyCouncilExecutiveCommittee,Member,ELECTED2014for3-yearterm.Chair-Elect,ELECTED2014.Chair,FacultyForwardTaskForce–FacultyPromotionandRetention.Member,FacultyForwardTaskForce–FacultyScholarship.

09/2014 –08/201709/2014 –08/201510/2014 –present10/2014 –present

• Member,GSBSAdmissionsCommittee. 02/2014 –present• Member,GSBSTaskForce,tasks:developmentandimplementation

ofuniformqualifyingexaminationandstrategiesforreducingthenumberofconcentrationswithinthebiomedicalsciencesgraduateprogram.

06/2013 –11/2014

• Member,Sex-andGender-BasedMedicine(SGBM)SymposiumPlanningCommittee,TTUHSCOfficeoftheProvostandLauraW.BushInstituteforWomen'sHealth.

05/2013 –present

• Interviewer,UndergraduatetoMedicalSchoolInitiative(UMSI)Program,SOM.

03/2013

• Organizer,TTUHSCGSBSGraduateFairTable,AnnualMeetingoftheBiophysicalsociety.

02/2013

• Member,InternalProgramReviewCommittee,GSBSProgramReview.

11/2012

• Organizer,NationalPostdocAppreciationWeek,postdocluncheon,speakerDr.Stocco.

09/2012

• Member,LubbockLibraryCommittee,ELECTED2012for3-yearterm.

09/2012 –08/2015

• Member,Dean’sScholarshipAwardCommittee,GSBS. 07/2012• Secretary,GSBSGraduateFacultyandGraduateCouncil,ELECTED

2012,2013,2014.05/2012 –08/2015

• Member,GSBSGraduateCouncil,2011-2013,2013-2015. 09/2011 –present• AssistanttoGraduateAdvisor,DepartmentofCellPhysiologyand

MolecularBiophysics.09/2011 –present

• FounderandOrganizer,MemBRAINYClub(JournalClubandWorkinProgress)oftheDepartmentofCellPhysiologyandMolecularBiophysics.

09/2011 –present

• Volunteer,TTURealityCheckprogram. 02/2011• Member,TTUHSCSOMMedicalStudentsAdmissionsCommittee. 09/2010 –present• GraduateDean’sRepresentative,ShouryadeepSrivastava’sdefense

(03/22/2010).03/2010

• PosterJudge,StudentResearchWeek. 03/2010 –present• Tourhost,GSBSRecruitmentDinnerandTour. 01/2010 –present• Interviewer,HowardHughesMedicalInstitute(HHMI)

undergraduateprogramatTTU.2009

• Organizer,TTUHSCGSBSGraduateFairTable,AnnualMeetingoftheBiophysicalsociety.

02/2009

• OrganizerandDesignerforremodeling,LARCFroghousing. 12/2008 –05/2009


Albert Einstein College of Medicine, New York, NY, USA AsPostdoctoralResearchAssociate

• Organizer,PosterSessionsandPosterAwardsfortheannualretreatoftheDepartmentofPhysiologyandBiophysics.

2007

• Member,EinsteinPostdoctoralAssociation,AlbertEinsteinCollegeofMedicine.

2007–2008 2003

• Senator,AlbertEinsteinCollegeofMedicine. 2007–2008 2003

Johannes Gutenberg-University, Mainz, Germany AsPharm.D.Student,GraduateStudentandPost-doc

• FounderandOrganizer,LectureSeriesfortheInterdisciplinaryGroupofPositronEmissionTomography(PET)Researchers.

2002–2003 2003

• Internship,Aventis(AnalyticalSciencesandApprovalDepartments),Frankfurt,Germany.

2001

• Member,DepartmentalCouncilofChemistryandPharmacy. 1999–2000• Member,BoardoftheGermanPharmaceuticalStudents‘

Association(BPhD)o Foreign-affairsandStudent-Exchange-Officerforthe

InternationalPharmaceuticalStudents‘Federation(IPSF)o German-Translation-OfficeforIPSFo Contact-PersonforIPSFo ParticipationattheEuropeanPharmaceuticalStudents‘

Association(EPSA)conference,Krakow,Polando ParticipationattheIPSFconference,Accra,Ghana.

1995–1999

Faculty Development Courses

Association of American Medical Colleges, USA • Participant,EarlyCareerWomenFacultyProfessionalDevelopment

Seminar2014

TTUHSC, Lubbock, TX, USA • Participant,FacultyLeadershipStudyGroup(FLSG) 2014,2016 • Participant,Lessons,LifeandLeadershipSeminarSeriesforWomen

FacultyinAcademicMedicine2014,2016

• Participant,MedicalEducation 2012• Participant,AcademicSocialization 2011

Teaching Experience

TTUHSC, Lubbock, TX, USA MedicalSchool

• Lecturer“StructureandFunctionoftheMajorOrganSystems”(MSCI5030):MusclePhysiology:Spring2011,Spring2013-present.

2011–present


GastrointestinalPhysiology:Spring2017-present

GraduateSchool• Co-developerandlecturer“ExperimentalBiochemistryand

BiophysicsofMembranes”(GMBP6205):Spring2017.2016–present

• Co-developerandlecturer“BiochemistryandBiophysicsofMembranes”(GMBP6305):Spring2017.ChemicalBiology,Ligand-GatedIonChannels,G-Protein-CoupledReceptors,Pharmacoperones

2016–present

• Coursedirectorandlecturer“AdvancedTopicsinPhysiology”(GPHY6305):SpecialEmphasisonReviewWritingandLibraryTools,Spring2013.

2013Spring

• Coursedirectorandlecturer“AdvancedTopicsinPhysiology”(GPHY6305):SpecialEmphasisonIonChannelandTransporterStructureandFunctionStudies,Fall2012.

2012Fall

• Co-developerandlecturer“ExperimentsinMolecularCellPhysiology”(GPHY5220):Spring2012,Spring2013,Spring2014.

2011–present

• Co-developerandlecturer“MolecularCellPhysiology”(GPHY5320):Spring2012,Spring2013,Spring2014.

2011–present

• Lecturer“CoreII:Cells”(GPHY5372):Fall2011,Fall2012,Fall2013,Fall2014,Fall2015,Fall2016.

2011–present

• Lecturer“HumanPhysiology”(GPHY5302):Spring2011,Spring2012,Spring2014,Spring2015,Spring2016.

2010–present

• Facilitator“ReadingsinPhysiology”(GPHY7102):Fall2009,Spring2010,Fall2010.

2010–present

• Lecturer“AdvancedTopicsinPhysiology(Topics:BiophysicsofMembraneProteins)”(GPHY6305):Fall2009,Fall2010.

2009–present

Johannes Gutenberg-University, Mainz, Germany SchoolofPharmacy

• Lecturer“Instrumentalanalytics”. 2001–2003• Instructorofthepracticalcourse“Identificationandquantification

ofdrugs(PharmaceuticalChemistryIII)”.2001–2003

• Lecturerofregularseminar“MedicinalChemistry”. 2001–2003• Taughttechniciansaswellassupervisedtheirwork. 2001–2003• Lecturerofregularseminar“Nomenclatureoforganiccompounds”. 1997–2003• Lecturerofregularseminar“Stereochemistry”. 1997–2002• Instructorofthepracticalcourse“Synthesisoforganicdrugs

(PharmaceuticalChemistryI)”.1997–2001

Mentoring and Advising

Technicians • NarongSok,2016/07–2016/10,DepartmentofCellPhysiologyandMolecular

Biophysics,TTUHSC.


• NanhPhan,2015/11–2016/08,DepartmentofCellPhysiologyandMolecularBiophysics,TTUHSC.CurrentlyTechnician,UTSouthwesternMedicalCenter.

• RamanGoyal,2009/03-2012,DepartmentofCellPhysiologyandMolecularBiophysics,TTUHSC.Subsequently,2012-2014,LabManagerandResearchTechnicianIIatDukeUniversityMedicalCenter,IonChannelResearchUnit.PhysiologyGraduateStudentatUniversityofCaliforniaatDavis,starting2014.

• GauthamBrahmamudi,2009-2010,DepartmentofCellPhysiologyandMolecularBiophysics,TTUHSC.Subsequently,obtainedMBAatTTUin2012.CurrentlyManager,TechnologyTransfer,CenterforInnovation,Arlington,TX.

Postdoctoral Researchers • SitaNirupamaNishtala,05/2015–08/31/2015,DepartmentofCellPhysiologyand

MolecularBiophysics,TTUHSC.• AkashPandhare,06/2014–present,DepartmentofCellPhysiologyandMolecular

Biophysics,TTUHSC.• NelliMnatsakanyan,07/2011–08/2014,DepartmentofCellPhysiologyandMolecular

Biophysics,TTUHSC.CurrentlyAssociateResearchScientist(LaboratoryofElizabethA.Jonas,M.D.),DepartmentofNeurobiology,Yale,NewHaven,CT,started09/2014.

Visiting Scientist • DominiqueGagnon,TTU,06/2014–09/2014,DepartmentofCellPhysiologyand

MolecularBiophysics,TTUHSC.

Graduate Students TTUHSC,Lubbock,TX,USA

SponsoredGraduateStudents• AntoniaStuebler,TTUHSCPh.D.Student(researchperformedinmylaboratory,Summer

2016-present;Chair,DissertationDefenseCommittee).• MinaAhmadi,TTUHSCBiotechnologyM.S.Student(researchperformedinmy

laboratory,Spring2016–Spring2017;Chair,Master’sCommittee).AfterwardsPh.D.PrograminChemistryattheUniversityofMinnesota.

• ElhamPirayesh,TTUHSCPh.D.Student(researchperformedinmylaboratory,Summer2016-present;Chair,DissertationDefenseCommittee).

• ElhamPirayesh,M.S.Spring2016,TTUHSCBiotechnologyM.S.Student(researchperformedinmylaboratory,Summer2015–Spring2016;Chair,Master’sCommittee).

• SwapneetaDate,Ph.D.Spring2016,TTUHSCCellPhysiologyandMolecularBiophysicsPh.D.Student(thesisworkperformedinmylaboratory;Chair,DissertationDefenseCommittee).AfterwardsbriefpostdocatColumbiaUniversity,NewYork,NY.Currently,postdocandOakRidgeNationalLaboratory,OakRidge,Tennessee.

! UndermymentoringSwapneetawashonoredwithseveralawards:MaryLouClements-Mannendowedscholarship,2014and2015;TTUHSCStudentResearchWeekScholarship(2015);1stprize14thAnnualTTUGraduateResearchCompetition(2015);StudentResearchWeekpostercompetitionaward(2015);andBiophysicalSocietyEducationCommitteeTravelAward(2015);Dean’sAwardoftheGraduateSchoolofBiomedicalScience(GSBS)atTTUHSC;OutstandingGraduateStudentAwardbytheGSBS,whichisawardedtothebestgraduatingPh.D.studentinasemester.


• SitaNirupamaNishtala,Ph.D.Spring2015,TTUHSCPharmacologyandNeurosciencePh.D.Student(thesisworkperformedinmylaboratory;Chair,DissertationDefenseCommittee).CurrentlypostdocattheAlbertEinsteinCollegeofMedicine,Bronx,NY.

• PhaneendraKumarDuddempudi,Ph.D.Spring2013,TTUHSCPharmacologyandNeurosciencePh.D.Student(thesisworkperformedinmylaboratoryandDr.Blanton’slaboratory;Co-ChairDissertationDefenseCommittee).CurrentlypostdocattheAlbertEinsteinCollegeofMedicine,Bronx,NY.

• JonathanEdwardPauwels,M.S.Spring2012,TTUBiotechnologyMasterStudent(thesisworkperformedinmylaboratory;Chair,Master’sThesisCommittee).CurrentlyresearchassistantatUTSouthwestern,PathologyDepartment,Dallas,TX,andstartedDentalSchoolatColumbiaUniversity,NewYork.

• RobinRajan,M.S.Summer2011,TTUBiotechnologyMasterStudent(thesisworkperformedinmylaboratory;Chair,Master’sThesisCommittee).CurrentlyResearchAssociate,SchoolofPharmacy,Abilene,TX.

• PrachiNakashe,M.S.Fall2010,TTUBiotechnologyMasterStudent(thesisworkperformedinmylaboratory;Chair,Master’sThesisCommittee).2011:ResearchAssociate,BiooScientific,Austin,TX,2013:ResearchAssociate,UTSouthwesternMedicalCenter;2015:SeniorResearchAssociate,Sequenom,SanDiego,CA.

(Thesis)CommitteeMember• DylanMeyers,TTUHSCPharmacologyandNeurosciencePh.D.Student(Member,

QualifyingExamCommittee,Spring2017;Member,DissertationDefenseCommittee;expectedgraduationin2019).

• FarazMohammadri,TTUHSCCellPhysiologyandMolecularBiophysicsPh.D.Student(Member,QualifyingExamCommittee,Spring2017;Member,DissertationDefenseCommittee;expectedgraduationin2017).

• NarongSok,M.S.Spring2016,TTUHSCBiotechnologyM.S.Student(Member,Committee).

• JeremyThompson,Ph.D.Summer2017,TTUHSCPharmacologyandNeurosciencePh.D.Student(Member,DissertationCommittee).AfterwardsbacktoTTUHSCSOMforfinishingMD.

• BenjaminElberson,Summer2017,TTUHSCCellPhysiologyandMolecularBiophysicsM.D.-Ph.D.Student(Member,DissertationDefenseCommittee;expectedgraduationSummer2017).AfterwardsbacktoTTUHSCSOMforfinishingMD.

• CholponTilegenova,Ph.D.Summer2016,TTUHSCCellPhysiologyandMolecularBiophysicsPh.D.Student(Member,QualifyingExamCommittee,Summer2014;Member,DissertationDefenseCommittee).

• AkashPandhare,Ph.D.Spring2014,TTUHSCPharmacologyandNeurosciencePh.D.Student(Member,DissertationDefenseCommittee).CurrentlyPostdoctoralResearchAssociateinmylaboratory.

• GregFendley,M.S.Spring2014,TTUHSCBiotechnologyM.S.Student(Member,Master’sThesisCommittee).CurrentlyTTUHSCPh.D.Student.

• AdamSnow,M.S.Spring2013,TTUHSCBiotechnologyMasterStudent(Member,Master’sThesisCommittee).

• RebeccaSissonCooper,Ph.D.Spring2013,TTUHSCCellPhysiologyandMolecularBiophysicsPh.D.Student(Member,QualifyingExamCommittee,Fall2010).Currentlypostdoc.


• RyanDowney,M.S.2010(Member,Master’sThesisCommittee),DepartmentofCellPhysiologyandMolecularBiophysics,TTUHSC.CurrentlyinIntegrativeBiologyGraduateProgram,UTSouthwesternMedicalCenter,Dallas,TX.

Externalcommitteemember• NicoleMcKinnon,Ph.D.Sept.2010(Member,DefenseCommittee),Departmentof

PhysiologyandBiophysics,AlbertEinsteinCollegeofMedicine,NewYork.CurrentlyResident,Pediatrics,ColumbiaUniversity,NewYork,NY.

Medical Students TTUHSC,Lubbock,TX,USA

• AliAhmed,2017TTUHSCMedicalStudentSummerResearchProgram.• JackLittlejohn,2017TTUHSCMedicalStudentSummerResearchProgram.• TrevorAnderson,10/2016–05/2017,TTUHSCMedicalStudent,LaboratoryInternship

duringleaveofabsence.• JosephD.Witt,2016TTUHSCMedicalStudentSummerResearchProgram.• MichaelA.Strong,2016TTUHSCMedicalStudentSummerResearchProgram.• GraceShim,02/2016–03/2016,TTUHSCMedicalStudent,LaboratoryInternship.• LauraDelin,2015TTUHSCMedicalStudentSummerResearchProgram.Currentlyinthe

2ndyearofmedicalschool.• Chun(Frankie)Leung,2015TTUHSCMedicalStudentSummerResearchProgram.

Currentlyinthe1styearofmedicalschool.• Chun(Frankie)Leung,02/2015–05/2015,TTUHSCMedicalStudent,Laboratory

Internshipduringleaveofabsence.• JeremyThompson,2014,TTUHSCM.D.-Ph.D.LaboratoryRotation(07/2014-09/2014).• Cheng-YenCharlesChen,2014,TTUHSCMedicalStudentSummerResearchProgram.

Currentlyinthe3rdyearofmedicalschool.• YidongChen,2013,TTUHSCMedicalStudentSummerResearchProgram.Currentlyinthe

4thyearofmedicalschool.• AndrewFrankNavetta,2011,TTUHSCMedicalStudentSummerResearchProgram.

CurrentlyResident(started2014),SurgeryPreliminary/UrologyResidencyProgram,TexasA&M–Scott&White,Temple,TX.

• AhmedAbdullahSalahudeen,2010,TTUHSCMedicalStudentSummerResearchProgram.CurrentlyResident(started2013),InternalMedicineResidencyProgram,UniversityofTexasMedicalSchool,Houston,TX.

• DaneLangsjoen,2009,TTUHSCMedicalStudentSummerResearchProgram.Currentlyresident(started2012),InternalMedicineResidencyProgram,TexasA&M–Scott&White,Temple,TX.

AlbertEinsteinCollegeofMedicine,NewYork,NY,USA• RogerErnestWiltfong,2007,AlbertEinsteinCollegeofMedicine,SummerResearch.

Currentlyresident(MDgraduation2010),OrthopedicsResidencyProgram,MountCarmel,Columbus,OH.

Undergraduate Students • ElizabethAndersen,06/2017–present,LabVolunteer,TTU,Lubbock.• CarlaBassil,2017,TTUClarkScholar,TX.


• OscarWu,09/2016–05/2017,LabVolunteer,TTU,Lubbock.• DanielCherkowsky,01/2016–05/2016,LabVolunteer,TTU,Lubbock.• DakotaKilcrease,10/2015–01/2016,CISER/SSOHonorsStudentLabIntern,TTU,

Lubbock.• KatherineJenkins,2015,TTUHSCSummerAcceleratedResearchProgram(SABR),TTU,

Lubbock.• AneeshPappu,2014,TTUClarkScholar,TX.• AnnaSabrinaBeroncalDeLeon,2014,SummerAcceleratedResearchProgram(SABR).• AfzalAhrorov,06/2012-07/2013,HHMIProgram,TTU,TX.CurrentlyinGraduateSchool

attheUniversityofHouston(started2013),CellandMolecularBiology,specializinginCancerBiology,Houston,TX.

• TerezaTomankova,2012,TTUHSCSummerAcceleratedResearchProgram(SABR),MuskingumUniversity,OH.CurrentlyMedicalSchoolinPrague(started2013),CzechRepublic.

• ZoltanKrudy,2011,TTUHSCSummerAcceleratedResearchProgram(SABR),TTU,TX.AdmittedtoPaulFosterSchoolofMedicine(tostart2014),ElPaso,TX.

• ValentinaSnetkova,2010,TTUHSCSummerAcceleratedResearchProgram(SABR),Jakobs-University,Germany.CurrentlyintheBiomedicalSciences(StemCellsTrack)GraduateProgramatNYUSchoolofMedicine,NY.

• JuanOrtega,2010,TTUPlainsBridgestotheBaccalaureateProgram,SouthPlainsCollege,Levelland,TX.

• CamillePerot,2009,TTUHSCSummerAcceleratedResearchProgram(SABR),UniversitédePoitiers,Poitiers,France.

• RuthD’Cunha,2009,TTUClarkScholar,TX.

Invention Disclosures • JansenM(PI),DateS,Proton-coupledfolatetransporterinteractionkit,TTUSystem

OfficeofResearchCommercialization,D-1277,filed02/2016.• JansenM(PI),GrozdanovPN,Solublechimerasoftheintracellulardomainofpentameric

ligand-gatedionchannels,TTUSystemOfficeofResearchCommercialization,D-1277,filed02/2016.iEdison8285901-16-0017.

Publications (all peer-reviewed) 1. DateSS,FioriMC,AltenbergGA,JansenM.HeterologousExpression,Purificationand

FunctionalCharacterizationoftheHumanProton-CoupledFolateTransporter(HsPCFT,SLC46A1)inSf9InsectCells.PLoSOne.12,e0177572.PMID:28493963.

2. PandhareA,PappuA,WilmsH,BlantonMP,JansenM.(2017)TheAntidepressantBupropionisaNegativeAllostericModulatoratSerotoninType3AReceptors.Neuropharmacology,113,89-99.PMID:27671323.

3. PandhareA,GrozdanovPN,JansenM.(2016)Pentamericquaternarystructureoftheintracellulardomainofserotonintype3Areceptors.ScientificReports.2016Apr5;6:23921.PMID:27045630.

4. DateS,ChenC,ChenY,JansenM.(2016)ExperimentallyOptimizedThreadingStructuresoftheProton-CoupledFolateTransporterinInward-andOutward-OpenStates.FEBSOpenBio.6,216-30.PMID:27047750.


5. NisthalaN,MnatsakanyanN,PandhareA,LeungC,JansenM.(2016)Directinteractionofthechaperoneresistancetoinhibitorsofcholinesterase(RIC-3)proteinwiththeserotoninreceptortype3A(5-HT3A)intracellulardomain.J.Neurochem.137,528-38.PMID:26875553.

6. MnatsakanyanN,NishtalaN,PandhareA,FioriMC,GoyalR,PauwelsJE,NavettaA,AhrorovA,JansenM.(2015)FunctionalchimerasofGLICObtainedbyAddingtheIntracellularDomainofAnion-andCation-ConductingCys-LoopReceptors.Biochemistry.54,2670-2682.PMID:25861708.

7. DuddempudiPK,GoyalR,DateS,JansenM.(2013)DelineatingtheExtracellularWater-AccessibleSurfaceoftheProton-CoupledFolateTransporter.PLoSOne.8,e78301.PMID:24205192.

8. DuddempudiPK,NakasheP,BlantonM,JansenM.(2013)TheMonomericStateoftheProton-CoupledFolateTransporterRepresentstheFunctionalUnitinthePlasmaMembrane.FEBSJ.280,2900-2915.PMID:23601781.

9. MnatsakanyanN,JansenM.(2013)ExperimentalDeterminationoftheRegisterBetweentheSecondandThirdTransmembraneSegmentsofMuscleNicotinicAcetylcholineReceptors.J.Neurochem.125,843-854.PMID:23565737.

10. LabriolaJM,PandhareA,JansenM,BlantonMP,CorringerPJ,BaenzigerJE.(2013)StructuralSensitivityofaProkaryoticPentamericLigand-gatedIonChanneltoitsMembraneEnvironment.J.Biol.Chem.286,11294-11303.PMID:23463505.

11. PandhareA,HamoudaAK,StaggsB,AggarwalS,DuddempudiPK,LeverJR,LapinskyDJ,JansenM,CohenJB,BlantonMP.(2012)BupropionBindstoTwoSitesintheTorpedoNicotinicAcetylcholineReceptorTransmembraneDomain:APhotoaffinityLabelingStudywiththeBupropionAnalog[125I]-SADU-3-72.Biochemistry.51,2425-2435.PMID:22394379.

12. GoyalR,SalahudeenAA,JansenM.(2011)EngineeringaProkaryoticCys-LoopReceptorwithaThirdFunctionalDomain.J.Biol.Chem.286,34635–34642.PMID:21844195.

13. BaumanA,PielM,HoehnemannS,KraussA,JansenM,SolbachC,DannhardtG,RoeschF.(2011)Synthesis,LabellingandEvaluationofHydantoine-SubstitutedIndoleCarboxylicAcidsasPotentialLigandsfortheGlycineBindingSiteoftheNMDAReceptor.J.LabelledCompd.Radiopharm.54,645-656.

14. WiltfongRE,JansenM.(2009)ProbingProteinPackingSurroundingtheResiduesInandFlankingtheNicotinicAcetylcholineReceptorM2M3Loop.J.Neurosci.29,1626-1635.

15. BaliM,JansenM,AkabasMH.(2009)GABA-InducedIntersubunitConformationalMovementintheGABAAReceptorα1M1-β2M3TransmembraneSubunitInterface:ExperimentalBasisforHomologyModelingofanIntravenousAnestheticBindingSite.J.Neurosci.29,3083-3092.PMID:19279245.

16. JansenM,RabeH,StrehleA,DielerS,DebusF,DannhardtG,AkabasMH,LüddensH.(2008)SynthesisofGABAAReceptorAgonistsandEvaluationoftheirα-SubunitSelectivityandOrientationintheGABABindingSite.J.Med.Chem.51,4430-4448.PMID:18651727.

17. ZhaoR,QiuA,TsaiE,JansenM,AkabasMH,GoldmanID.(2008)TheProton-CoupledFolateTransporter(PCFT):ImpactonPemetrexedTransportandonAntifolatesActivitiesasComparedtotheReducedFolateCarrier.Mol.Pharm.74,854-862.PMID:18524888.

18. JansenM,BaliM,AkabasMH.(2008)ModularDesignofCys-loopLigand-GatedIonChannels:Functional5-HT3andGABAρ1ReceptorsLackingtheLargeCytoplasmicM3M4Loop.J.Gen.Physiol.131,137-146.PMID:18227272.

19. QiuA,MinS,JansenM,MalhotraU,TsaiE,CabelofDC,MatherlyL,ZhaoR,AkabasMH,GoldmanID.(2007)RodentIntestinalFolateTransporters(SLC46A1):Secondary


Structure,FunctionalProperties,ResponsetoDietaryFolateRestriction.Am.J.Physiol.-CellPhysiol.293,C1669-78.PMID:17898134.

20. QiuA,JansenM,SakarisA,MinSH,ChattopadhyayS,TsaiE,SandovalC,ZhaoR,AkabasMH,GoldmanID.(2006)IdentificationofanIntestinalFolateTransporterandtheMolecularBasisforHereditaryFolateMalabsorption.Cell127,917-928.PMID:17129779.

21. JansenM,AkabasMH.(2006)State-DependentCross-LinkingoftheM2andM3Segments:FunctionalBasisfortheAlignmentofGABAAandAcetylcholineReceptorM3Segments.J.Neurosci.26,4492-4499.PMID:16641228.

22. ReevesDC,JansenM,BaliM,LemsterT,AkabasMH.(2005)ARolefortheβ1-β2LoopintheGatingof5-HT3Receptors.J.Neurosci.25,9358-9366.PMID:16221844.

23. JansenM,DannhardtG.(2003)VariationsofAcidicFunctionsatPosition2andSubstituentsatPositions4,5and6oftheIndoleMoietyandtheirEffectonNMDA-GlycineSiteAffinity.Eur.J.Med.Chem.38,855-865.PMID:14575932.

24. JansenM,PotschkaH,BrandtC,LöscherW,DannhardtG.(2003)HydantoinSubstituted4,6-Dichloroindole-2-CarboxylicAcidsasLigandswithHighAffinityfortheGlycineBindingSiteoftheNMDAReceptor;J.Med.Chem.46,64-73.PMID:12502360.

25. PielM,SchirrmacherR,HöhnemannS,HamkensW,KohlB,JansenM,SchmittU,LüddensH,DannhardtG,RöschF.(2003)SynthesisandEvaluationof5,7-Dichloro-4-(3-{4-[4-(2-[18F]fluoroethyl)-piperazin-1-yl]-phenyl}-ureido)-1,2,3,4-tetrahydroquinoline-2-carboxylicacidasaPotentialNMDALigandtoStudyGlutamatergicNeurotransmissionin-vivo.J.LabelledComp.Radiopharm.46,645-659.

Reviews and Bookchapters (peer-reviewed) • PindurU,JansenM,LemsterT.(2005)AdvancesinDNA-LigandswithGrooveBinding,

Intercalatingand/orAlkylatingActivity:Chemistry,DNA-BindingandBiology.Curr.Med.Chem.12,2805-2847.PMID:16305474.

• JansenM,DannhardtG.(2003)AntagonistsandAgonistsattheGlycineSiteoftheNMDAReceptorforTherapeuticInterventions.Eur.J.Med.Chem.38,661-670.PMID:12932897.

Abstracts (peer-reviewed)

Symposium Presentations (invited) • JansenM.(02/28/2016)InsightsintoIntracellularDomainsofpentamericLigand-Gated

IonChannels.60thAnnualMeeting,LosAngeles,2016BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,110,3,68-Symp.

Posters • StueblerA,ArtigasP,JansenM.(02/2017)TheIntracellularDomainofPentameric

Ligand-GatedIon-ChannelsanditsEffectonReceptorConductanceinGLICChimeras.61stAnnualMeeting,NewOrleans,2017BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,BiophysicalJournal,112,3,2723-Pos.

• AhmadiM,PandhareA,JansenM.(02/2017)DevelopmentofaPentameric,Non-Chimeric5-HT3AReceptorIntracellularDomainConstruct.61stAnnualMeeting,NewOrleans,2017BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,BiophysicalJournal,112,3,2733-Pos.

• PandhareA,JansenM.(02/2017)CharacterizingtheIntrinsicAssemblyBehaviorofthe5-HT3AReceptorIntracellularDomain.61stAnnualMeeting,NewOrleans,2017


BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,BiophysicalJournal,112,3,2732-Pos.

• PirayeshE,PandhareA,JansenM.(02/2017)Determinantsof5-HT3AIntracellularDomainOligomerizationandRIC-3Interaction.61stAnnualMeeting,NewOrleans,2017BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,BiophysicalJournal,112,3,2731-Pos.

• PandhareA,PirayeshE,GrozdanovPN,JansenM.(11/2016)StudyingtheStructure,FunctionandInteractionsoftheIntracellularDomainofCys-loopReceptors.Neuroscience2016,SanDiego,CA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience.682.11-Pos.

• PandhareA,StueblerA,PirayeshE,AhmadiM,ArtigasP,JansenM.(10/2016)Identificationofpositionscrucialforthepentamericassemblyoftheintracellulardomainofpentamericligand-gatedionchannels.Poster.XVthInternationalSymposiumonCholinergicMechanisms(ISCM),16-20thofOct.2016,Marseille,France.

• PirayeshE,LeungF,PandhareA,JansenM.(03/2016)CharacterizationoftheInteractionoftheintracellulardomainof5-HT3AreceptorswiththechaperoneproteinRIC-3.60thAnnualMeeting,LosAngeles,2016BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,BiophysicalJournal,110,3,2234-Pos.

• JenkinsK,PandhareA,DelinLJ,JansenM.(03/2016)ExpressionandPurificationoftheIntracellularDomainofaCationicPentamericLigand-GatedIonChannel.60thAnnualMeeting,LosAngeles,2016BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,BiophysicalJournal,110,3,2974-Pos.

• DelinLJ,PandhareA,JenkinsK,JansenM.(03/2016)ASolubleGABAAρ1ChimeraForStructuralStudies.60thAnnualMeeting,LosAngeles,2016BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,BiophysicalJournal,110,3,2245-Pos.

• PandhareA,GrozdanovPN,JansenM.(03/2016)PentamericStructureoftheSolubleIntracellularDomainof5-HT3AReceptors.60thAnnualMeeting,LosAngeles,2016BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,110,3,2235-Pos.

• DateS,FioriM,SokN,UrbatschI,JansenM.(02/2016)Expression,PurificationandFunctionalCharacterizationofHumanProton-CoupledFolateTransporter(SLC46A1).60thAnnualMeeting,LosAngeles,2016BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,110,3,696-Pos.

• PandhareA,JansenM.(10/2015)ExpressionandPurificationoftheIntracellularDomainofanAnionicPentamericLigand-GatedIonChannel.Neuroscience2015,Chicago,IL,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience.667.16-Pos.

• DateS,FioriMC,PurnaBM,SokN,UrbatschIL,JansenM.(07/2015)HeterologousOverexpressionofFunctionalProton-CoupledFolateTransporter.BiomedicalTransporters2015,Lugano,Switzerland.

• ThompsonJM,PappuA,PandhareA,JansenM.(02/2015)ComplexModulationoftheGABAAα1β2γ2ReceptorFunctionbyBupropion.59thAnnualMeeting,Baltimore,MD,2015BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,108,2,2177-Pos.

• PandhareA,GagnonD,WilmsH,BlantonMP,JansenM.(02/2015)InteractionofBupropionwith5-HT3AReceptors.59thAnnualMeeting,Baltimore,MD,2015BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,108,2,2175-Pos.

• DateS,ChenCYC,ChenY,JansenM.(02/2015)TheHumanProton-CoupledFolateTransporter:DeterminationofConfirmationandIdentificationoftheFolateBindingPocket.59thAnnualMeeting,Baltimore,MD,2015BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,108,2,1549-Pos.


• PandhareA,MnatsakanyanN,RielaS,BlantonMP,JansenM.(11/2014)MonitoringPentamericLigand-GatedIonChannelFunctionalityAlongtheAffinityPurificationProcess.Neuroscience2014,Washington,DC,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience.500.17-Pos.

• MnatsakanyanN,PandhareA,LeverJ,LapinskyD,WilmsH,BlantonMP,JansenM.(11/2014)IdentificationofBupropionBindingSitesinGLICwiththePhotoaffinityProbe[125I]-SADU-3-72.Neuroscience2014,Washington,DC,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience.500.20-Pos.

• MnatsakanyanN,CuelloL,JansenM.(02/2014)AssessingtheCys-LoopReceptorIntracellularDomainStructurebyEPR-Spectroscopy.58thAnnualMeeting,SanFrancisco,CA,2014BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,L4400-Pos.

• NishtalaN,JansenM.(02/2014)DirectInteractionofRIC-3withtheIntracellularDomainofEukaryoticCationicPentamericLigand-GatedIonChannels.58thAnnualMeeting,SanFrancisco,CA,2014BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,1730-Pos.

• DateS,JansenM.(02/2014)ExperimentallyDefinedStructuralModelofHumanProton-CoupledFolateTransporter.58thAnnualMeeting,SanFrancisco,CA,2014BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,1858-Pos.

• PandhareA,RielaS,JansenM,BlantonMP.(02/2014)NeuronalNicotinicAcetylcholineReceptors:TheDevelopmentofMethodsforProducingAffinity-PurifiedandLipid-ReconstitutedReceptorsthatRetainFunctionality.58thAnnualMeeting,SanFrancisco,CA,2014BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,1719-Pos.

• MnatsakanyanN,NishtalaSN,AhrorovA,JansenM.(11/2013)StructureoftheIntracellularDomainofPentamericLigand-GatedIonChannels.Neuroscience2013,SanDiego,CA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,319.01-Pos.

• DateSS,ChenY,DuddempudiPK,GoyalR,JansenM.(11/2013)ExperimentalVerificationandOptimizationofComputationally-derivedModelsoftheProton-CoupledFolateTransporter(PCFT).GenderSpecificMedicine&Women'sHealthSymposium.TTUHSCOfficeofthePresident&OfficeoftheProvostincollaborationwithLauraW.BushInstituteforWomen'sHealth.Lubbock,TX:TTUHSC.

• MnatsakanyanN,NishtalaSN,JansenM.(02/2013)AnalysisofSecondaryStructureElementsintheIntracellularDomainofGLICChimeraswithICDfromEukaryoticCys-LoopReceptors.57thAnnualMeeting,Philadelphia,PA,2013BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,3268-Pos.

• DateSS,DuddempudiPK,JansenM.(02/2013)TopologyofHumanProton-CoupledFolateTransporterExpressedinE.Coli.57thAnnualMeeting,Philadelphia,PA,2013BiophysicalSocietyMeetingAbstracts.BiophysicalJournal,Supplement,1,556-Pos.

• NishtalaSN,PauwelsJE,MnatsakanyanN,GoyalR,JansenM.(10/17/2012)StudiesofFunctionalGLICChimeraswithEukaryoticIntracellularDomain.Neuroscience2012,NewOrleans,LA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,739.08-Pos.

• MnatsakanyanN,JansenM.(10/17/2012)OrientationoftheM2andM3SegmentsofNicotinicAcetylcholineReceptors:ExperimentalEvidencefortheCorrectRegisterbetweenM2andM3.Neuroscience2012,NewOrleans,LA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,739.19-Pos.

• MnatsakanyanN,JansenM(07/2012).OrientationoftheM2andM3SegmentsofNicotinicAcetylcholineReceptors:ExperimentalEvidencefortheCorrectRegisterBetweenM2andM3.GordonResearchConference-IonChannels,MountHolyokeCollege,SouthHadley,MA.


• GoyalR,NavettaA,NishtalaSN,SalahudeenAA,PauwelsJE,MnatsakanyanN,JansenM.(02/2012)Eukaryotic-ProkaryoticChimerasforStructure-FunctionStudiesoftheIntracellularDomainofCys-LoopReceptors.56thAnnualMeeting,SanDiego,CA,2012BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,588-Pos.

• DuddempudiPK,GoyalR,BlantonMP,JansenM.(02/2012)IdentifyingtheLipid-ProteinInterfaceoftheProton-CoupledFolateTransporterusingHydrophobicPhotoreactiveProbes.56thAnnualMeeting,SanDiego,CA,2012BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,2660-Pos.

• PandhareA,JansenM,BlantonMP.(02/2012)InjectionofAffinity-PurifiedLigand-GatedIon-ChannelsintoXenopusLaevisOocytesforFunctionalStudiesusingElectrophysiology.56thAnnualMeeting,SanDiego,CA,2012BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,595-Pos.

• PandhareA,HamoudaAK,StaggsB,DuddempudiPK,LeverJR,CohenJB,LapinskyDJ,JansenM,BlantonMP.(2012)BupropionBindsintheMiddle(M2-9)oftheTorpedoNicotinicAcetylcholineReceptorChannel.56thAnnualMeeting,SanDiego,CA,2012BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,594-Pos.

• GoyalR,SalahudeenAA,JansenM.(11/2011)EngineeringaThirdFunctionalDomainforaProkaryoticCys-LoopReceptor.Neuroscience2011,Washington,DC,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,ProgramNo.337.01-Pos.

• NakasheP,JansenM.(03/2011)AnalysisoftheOligomericStateofSurface-LocalizedProton-CoupledFolateTransporterbyBlueNativePolyacrylamideGelElectrophoresis.55thAnnualMeeting,Baltimore,MD,2011BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,1344-Pos.

• JansenM,BrahmamudiG.(11/2010)MobilityofChannelLiningTransmembraneSegmentsinMusclenAChReceptors.Neuroscience2010,SanDiego,CA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,239.18-Pos.

• NakasheP,DuddempudiPK,BlantonMP,JansenM.(02/2010)StructureandFunctionStudiesoftheProton-CoupledFolateTransporter.54thAnnualMeeting,SanFrancisco,CA,2010BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,2625-Pos.

• BrahmamudiG,LangsjoenD,D'CunhaRM,JansenM.(02/2010)HighlyMobileChannelLiningTransmembraneSegmentsinMuscleNicotinicAcetylcholineReceptors?54thAnnualMeeting,SanFrancisco,CA,2010BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,673-Pos.

• WiltfongRE,JansenM.(02/2009)ExperimentalValidationofEukaryoticCys-LoopReceptorHomologyModels:TorpedovsGLIC/ELICstructures?53rdAnnualMeeting,Boston,MA,2009BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1,L76-Pos.

• JansenM.(11/2008)HeteromericMusclenAChReceptorChannelsFunctionwithaHeptapeptideReplacingtheM3M4Loop.Neuroscience2008,Washington,DC,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,530.6-Pos.

• BaliM,JansenM,AkabasMH.(11/2008)DisulfideCross-LinkBetweenα1andβ2Subunitinα1β2γ2GABAAReceptorsatthePropofolBinding-Site.Neuroscience2008,Washington,DC,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,530.15-Pos.

• McKinnonN,JansenM,AkabasMH(11/2008)SizeMatters!FunctionalConstraintsontheLengthandAminoAcidCompositionoftheM3M4LoopofCys-LoopReceptorLigand-GatedIonChannels.Neuroscience2008,Washington,DC,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,530.1-Pos.


• WiltfongRE,JansenM.(11/2008)ConformationalChangesoftheNicotinicAcetylcholineReceptorM2M3Loop.Ligand-GatedIonChannels,18thNeuropharmacologyConference,NeuroscienceSatellite2008,Washington,DC,P1.11-Pos.

• JansenM,BaliM,AkabasMH.(2008)TheDispensableModule:Cys-LoopReceptorsLackingtheIntracellularDomain.GordonResearchConference-IonChannels,Tilton,NH.

• JansenM,BaliM,AkabasMH.(2008)5-HT3AandGABArho1ChannelsareFunctionalwithaHeptapeptideinPlaceoftheM3M4Loop.52ndAnnualMeeting,LongBeach,CA,2008BiophysicalSocietyMeetingAbstracts,BiophysicalJournal,Supplement,1323-Pos.

• BaliM,JansenM,AkabasMH.(2007)SpatialRelationshipbetweentheGABAAReceptorβ2M3Regionandtheα1SubunitPreM1Region.Neuroscience2007,SanDiego,CA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,441.8-Pos.

• QiuA,JansenM,SakarisA,MinSH,ChattopadhyayS,TsaiE,SandovalC,ZhaoR,AkabasMH,GoldmanID.(2007)TheMolecularBasisforHereditaryFolateMalabsorption.AmericanSocietyofPediatricHematology/Oncology20thAnnualMeeting,Toronto,Canada,ProgramNo.5868.2.PediatricBloodandCancer,48(6),616-616.

• JansenM,AkabasMH.(2005)TheMatingDanceoftheM2andM3TransmembraneDomainsoftheGABAAReceptor.Neuroscience2005,Washington,DC,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,488.3-Pos.

• PielM,HöhnemannS,JansenM,SchmittU,DannhardtG,RöschF.(2005)Synthesis,LabellingandEvaluationofaNewFluorinatedNMDALigandtoStudyGlutamatergicNeurotransmissioninvivo.16thInternationalSymposiumonRadiopharmaceuticalChemistry,IowaCity,IA,P01-12,Posterpresentation,J.Label.Compd.Radiopharm.48,Supplement1,81.

• BaumanA,PielM,HöhnemannS,JenneweinM,JansenM,KraussA,SchmittU,DannhardtG,RöschF.(2005)Synthesis,LabellingandEvaluationof4,6-Dichloro-3-((3-(4-(2-fluorethoxy)phenyl)2,4-dioxoimidazolidine)-1H-indole-2-carboxylicacidasRadiotracerforImagingtheNMDA-ReceptorStatusinvivo.16thInternationalSymposiumonRadiopharmaceuticalChemistry,IowaCity,IA,P01-31,Posterpresentation,J.Label.Compd.Radiopharm.48,Supplement1,100.

• BaumanA,PielM,HöhnemannS,JenneweinM,JansenM,KraussA,SchmittU,DannhardtG,RöschF.(2005)Synthesis,18F-LabellingandEvaluationofDDIC-1forImagingtheNMDA-ReceptorStatusinvivo.AnnualscientificmeetingoftheGermanPharmaceuticalSociety(DPHG),05th-08thofOct.2005,Mainz,Germany,Abstract:DPhGJahrestagung2005,104.

• JansenM,RabeH,DannhardtG,LüddensH,AkabasMH.(2004)DefiningtheBindingSiteforaNewGABAAReceptorLigand.Neuroscience2004,SanDiego,CA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,Neuroscience2004,51.10-Pos.

• ReevesDC,JansenM,BaliM,AkabasM.(2004)FunctionalEffectsofMutagenesisandChemicalModificationofa5-HT3Receptorβ1-β2LoopLysineResidue.Neuroscience2004,SanDiego,CA,AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,626.8-Pos.

• JansenM,RabeH,DannhardtG,LüddensH,SinkkonenST,KorpiE.(2003)TwoNovelGABAMimeticsRevealFunctionalDiscriminationonDifferentGABAAReceptorSubtypes.ProgramNo.824.Posterpresentationatthe29thGöttingenNeurobiologyConference,Göttingen,Germany.

• PielM,SchirrmacherR,HöhnemannS,HamkensW,JansenM,SchmittU,LüddensH,DannhardtG,RöschF.(2002)SynthesisandEvaluationofFluorinatedTetrahydroquinoline-2-carboxylicacidDerivativesasPotentialNMDALigandstoStudyGlutamatergicNeurotransmissioninvivo.AnnualCongressoftheEuropeanAssociationofNuclearMedicine,Vienna,Austria,Eur.J.Nucl.Med.29,Supplement1,373.


• DannhardtG,JansenM.(2000)Design,Synthesisandin-vitroEvaluationofAntagonistsfortheStrychnine-InsensitiveGlycineBinding-SiteoftheNMDAReceptor.PosterpresentationattheannualscientificmeetingoftheGermanPharmaceuticalSociety(DPHG),2000,Münster,Germany.

• DannhardtG,KohlB,JansenM.(1998)BenzimidazolesasLigandsfortheStrychnine-InsensitiveGlycineSiteoftheNMDAReceptor.PosterpresentationattheannualscientificmeetingoftheAustrianPharmaceuticalSociety(ÖPhG),Graz,Austria.

Talks • PandhareA,StueblerA,PirayeshE,AhmadiM,ArtigasP,JansenM.(2016)Identification

ofpositionscrucialforthepentamericassemblyoftheintracellulardomainofpentamericligand-gatedionchannels.OralPresentation.XVthInternationalSymposiumonCholinergicMechanisms(ISCM),16-20thofOct.2016,Marseille,France.

• JansenM,BaliM,ReevesDC,AkabasMH.(2007)Functional5-HT3AandGABArho1ChannelsObtainedafterReplacementoftheM3M4LoopbyaHeptapeptide.Neuroscience2007,SanDiego,CA,OralPresentation.AbstractViewer/ItineraryPlanner,SocietyforNeuroscience,441.9-Tlk.

• JansenM.(2002)Hydantoin-substituted4,6-Dichloroindole-2-carboxylicAcidsasHigh-AffinityLigandsoftheGlycineBindingSiteoftheNMDAReceptor.LectureattheannualscientificmeetingoftheGermanPharmaceuticalSociety(DPHG),09th-12thofOct.2002,Berlin,Germany.

• PielM,SchirrmacherR,HöhnemannS,HamkensW,KohlB,JansenM,SchmittU,LüddensH,DannhardtG,RöschF.(2002)5,7-Dichloro-4-(3-{4-[4-(2-[18f]fluoroethyl)-piperazin-1-yl]-phenyl}-ureido)-1,2,3,4-tetrahydroquinoline-2-carboxylicAcidasaPotentialNMDALigandtoStudyGlutamergicNeurotransmissioninvivousingPET.PosterattheAnnualScientificMeetingoftheGermanPharmaceuticalSociety(DPHG),09th-12thofOct.2002,Berlin,Germany.

• JansenM,PielM,KohlB,SchirrmacherR,HöhnemannS,HamkensW,SchmittU,LüddensH,RöschF,DannhardtG.(2002)Synthesis,PharmacologicalTestingand18F-FluorinationofNMDAReceptorLigands.InvitedlectureatthePET-Symposium,21stSept.2002,Mainz,Germany.

Presentations (invited, non peer-reviewed)

External Talks (Outside US) • JansenM.(12/2014)ChimerasfortheStudyoftheIntracellularDomainofPentameric

Ligand-GatedIonChannels.Invitedseminar,DepartmentofPharmacology,GoetheUniversity,Frankfurt,Germany.

• JansenM.(05/2014)ChimerasofPentamericLigand-GatedIonChannels.Invitedseminar,DepartmentofPharmacology,RWTHAachenUniversity,Aachen,Germany.

• JansenM.(05/2011)LessonsfromProkaryoticCys-LoopReceptors.Invitedseminar,DepartmentofBiochemistryandMolecularMedicine,UniversityofBern,Switzerland.

• JansenM.(05/2007)DevelopmentofSubtype-SelectiveGABAMimeticsandStructure-FunctionStudiesofGABAAReceptors.Invitedseminar,DepartmentofPharmaceuticalChemistry,Friedrich-Alexander-UniversityErlangen-Nuernberg,Erlangen,Germany.

External Talks (Inside US) • JansenM.(07/2015)TheIntracellularDomainofPentamericLigand-GatedIonChannels.

TellurideIonChannelBiophysics,Telluride,Co,USA.


• JansenM.(09/2014)TheIntracellularDomainofPentamericLigand-GatedIonChannels.Invitedseminar,TTUHSCSchoolofPharmacy,Amarillo,USA.

• JansenM.(12/2010)StructureFunctionStudiesofCys-LoopReceptors.Invitedseminar,DepartmentofPharmacologyandNeuroscience,UniversityofNorthTexasHealthScienceCenter,FortWorth,USA.

• JansenM.(09/2010)StructureFunctionStudiesoftheChannelLiningM2TransmembraneSegmentinMuscleNicotinicAcetylcholineReceptors.Invitedseminar,DepartmentofPhysiologyandBiophysics,AlbertEinsteinCollegeofMedicine,NewYork,NY.

• JansenM.(04/2008)InvestigatingtheStructureandFunctionofCys-LoopReceptors.Invitedseminar,DepartmentofPhysiologyandBiophysics,CaseSchoolofMedicine,CaseWesternReserveUniversity,Cleveland,USA.

• JansenM.(02/2008)InvestigatingtheStructureandFunctionofCys-LoopReceptors.Invitedseminar,DepartmentofPhysiologyandBiophysics,MillerSchoolofMedicine,UniversityofMiami,Miami,USA.

• JansenM.(01/2008)StructureandFunctionStudiesofCys-LoopReceptors.Invitedseminar,DepartmentofBiologicalSciences,UniversityofArkansas,Fayetteville,USA.

• JansenM.(01/2008)StructureandFunctionStudiesofCys-LoopReceptors.Invitedseminar,DepartmentofCellPhysiologyandMolecularBiophysics,TTUHSC,Lubbock,USA.

Local Talks (At Home Institution) • JansenM(04/27/2017)Regulationofalpha7nicotinicacetylcholinereceptorsinhuman

monocytesandpotentialimplicationsforsepsismanagement,2ndAnnualSymposium,CenterofExcellenceforTranslationalNeuroscienceandTherapeutics(CTNT),TTUHSC,Lubbock,USA.

• JansenM(02/09/2016)TheSpaghettiConundrum–OurJourneytoaDetailedUnderstandingoftheIntracellularDomainofPentamericLigand-GatedIonChannels.Invitedseminar,GarrisonAgingInstituteResearchSeminar,TTUHSC,Lubbock,USA.

• JansenM(10/02/2015)SolubleChimerasforStructuralStudiesoftheIntracellularDomainofPentamericLigand-GatedIonChannels,AnnualMeetingoftheCenterforMembraneProteinResearch,TTUHSC,Lubbock,USA.

• JansenM(11/05/2014)OfSpaghettisandPentamers-TheIntracellularDomainofCys-LoopReceptors.Invitedseminar,AnnualMeetingoftheCenterforMembraneProteinResearch,TTUHSC,Lubbock,USA.

• JansenM(10/10/2012)StructuralInvestigationsoftheProton-CoupledFolateTransporter.Invitedseminar,AnnualMeetingoftheCenterforMembraneProteinResearch,TTUHSC,Lubbock,USA.

• JansenM.(10/2011)StudiesofProkaryotic-EukaryoticCys-LoopReceptorChimeras.Invitedseminar,AnnualMeetingoftheCenterforMembraneProteinResearch,TTUHSC,Lubbock,USA.

• JansenM,BlantonMP.(06/2009)StructureFunctionStudiesofPCFT.InvitedSeminar,AnnualMeetingoftheCenterforMembraneProteinResearch,TTUHSC,Lubbock,USA.

• JansenM.(06/2009)ExperimentalValidationofEukaryoticCys-LoopReceptorHomologyModels.Invitedseminar,AnnualMeetingoftheCenterforMembraneProteinResearch,TTUHSC,Lubbock,USA.

• JansenM,BaliM,AkabasMH.(06/2007)5HT3ALight,ConductsGreat,LessFilling.Invitedseminar,DepartmentofPhysiologyandBiophysicsRetreat,AlbertEinsteinCollegeofMedicine,Bronx,USA.


• JansenM,AkabasMH(11/2006)TheMatingDanceoftheM2andM3TransmembraneDomainsoftheGABAAReceptor.SymposiumfortherecipientsoftheOutstandingPostdoctoralResearchScholarAwardoftheBelferInstituteforAdvancedBiomedicalStudies,AlbertEinsteinCollegeofMedicine,NewYork.

• JansenM,AkabasMH.(06/2006)TheMatingDanceoftheM2andM3TransmembraneDomainsoftheGABAAReceptor.Invitedseminar,DepartmentofPhysiologyandBiophysicsRetreat,AlbertEinsteinCollegeofMedicine,Bronx,USA.

• JansenM.(2003)Hydantoin-Substituted4,6-Dichloroindole-2-carboxylicAcidsasLigandsfortheGlycineBindingSiteoftheNMDAReceptorwithHighAffinity.InvitedlectureattheMedicinalChemistryPresentationattheInstituteofPharmacy,Mainz,Germany.

• PielM,SchirrmacherR,HöhnemannS,HamkensW,JansenM,SchmittU,LüddensH,DannhardtG,RöschF.(2002)SynthesisandEvaluationofNMDA-AntagonistsattheStrychnine-InsensitiveGlycineBindingSite.InvitedlectureatthePETCenterWinterLectureSeries,4thofDec.2002,Mainz,Germany.

• JansenM.(2002)PharmacodynamicParametersinGeneralandthe“lunatic”GABAAReceptorinParticular.Invitedlectureattheseminarseries“Molecularandcellularneurobiology”,IAK-Neuro,Mainz,Germany.

• JansenM.(2002)PharmacodynamicParameters(Kd,Ki,IC50,EC50).InvitedlectureatthePETCenterSummerLectureSeries,8thofMay2002,Mainz,Germany.

• Collaboration.LubbockGeneralFacultyMeeting.TTUHSC,Lubbock.

curriculum vitae michaela jansen, pharm.d., ph.d ...cv / michaela jansen, ph.d. 2/21 academic...

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