curriculum vitae - paul-martini-stiftung · 2019-04-21 · 2010 poster award of the university...

Curriculum Vitae: Prof. Dr. med. Sonja Schrepfer Updated November 2014

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CURRICULUM VITAE

Personal Details

Date of birth: December 26th, 1974

Place of birth: Wuerzburg

Nationality: German

married

Prof. Dr. med. Sonja Schrepfer Heisenbergprofessor (W3) and

Visiting Professor at Stanford University (CT Surgery)

University Heart Center Hamburg

Transplant and Stem Cell Immunobiology Lab (TSI)

Campus Forschung, N27

Martinistr. 52

20246 Hamburg

Phone:+49/40/741059982

[email protected]


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Education

2009-present Heisenberg Professor (W3) for Transplant Immunology and Stem Cell

Immunobiology, Cardiac Surgery

2007 Venia legendi for Immunology and Experimental Cardiac Surgery

(06/13/2007) (Habilitation)

2007 PhD (Immunology), Cardiovascular Surgery/ Institute of Immunology,

University Hamburg, Germany (02/13/2007)

2003 Doctoral Thesis (Medicine), Julius-Maximilian-University Wuerzburg, Germany

Dissertation: Estrogens delay the development of transplant vasculopathy after heterotopic heart transplantation in rats.

2003-2005 Resident Physician, Department of Cardiovascular Surgery, University

Hospital Hamburg (Germany)

2001-2002 Resident Physician, Department of Cardiac Surgery, University Hospital

Munich (Germany)

2001 Graduation, MD Degree (3. Staatsexamen: 1,0)

1995-2001 Medical School (University of Wuerzburg and University of Munich,

Germany), MD

Research Experience

2010/2011 Visiting Professor at the University Alberta, Edmonton, Canada

(Department of Cardiology and Pulmonary Hypertension) for 5 weeks

2009-present Heisenberg Professor (W3) and Lab Director at the University Heart

Center Hamburg, Transplant and Stem Cell Immunobiology Lab (TSI),

Germany

since 2009 Visiting Professor at Stanford University School of Medicine,

Department of Cardiothoracic Surgery, Transplant Immunology


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2007-2009 Instructor, Stanford University School of Medicine, Department of

Cardiothoracic Surgery, Transplant Immunology Lab, Stanford, CA

2006-2007 Postdoctoral Fellow, Stanford University School of Medicine,

Department of Cardiothoracic Surgery, Stanford, CA; Lab Director:

Robert C. Robbins, MD

2002-2006 Investigator/Instructor for Basic Science at University Hospital

Hamburg (Cardiovascular Surgery/ Institute of Immunology), Germany

2001-2002 Postdoctoral Fellow, Cardiothoracic Surgery, University Munich,

Germany

1999-2001 Doctoral Research, Thoracic- and Cardiovascular Surgery, University

Wuerzburg, Germany

1998-1999 Pre-doctoral Fellow, Thoracic- and Cardiovascular Surgery, University

Wuerzburg, Germany

Honors and Awards

2014 Innovation Award of the German Academia

2013 Leducq Transatlantic Exchange Award (for 2 years) from the

“LeDucq Fondation”, France

2012 TTS International Basic Science Award of the Transplantation

Society

2010 Norman E. Shumway Career Development Award of the ISHLT

(International Society for Heart and Lung Transplantation)

2009 W3-Heisenberg-Professor (DFG) in Transplant Immunology and

Stem Cell Immunobiology, Cardiac Surgery

2009 Best Abstract Basic Science from the German Transplant Society

(DTG)

2008 Finalist in the Vivien Thomas Award Session of the American Heart

Association (AHA)

2008 Best Scientific Abstract (11th Annual NewEra Cardiac Care:

Innovation&Technology)


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2007 Rudolf Pichlmayr Prize 2007 (from the German Transplant Society

(DTG), “named after the pioneer of German Transplant Medicine, the

prize is awarded for outstanding achievment in the transplant field”)

2007 Novartis Global Travel Award (Basic Science Symposium of the

Transplantation Society 2007)

2007 ATC Young Investigator Award (American Transplant Congress 2007)

2006 Lilly-Research-Award for the best publication in preventive medicine

(Schrepfer at al., Menopause 2006)

2005 Christian-Lauritzen-Award of Germany

2005 German Society for Thoracic- and Cardiovascular Surgery Best Oral

Presentation Award

2005 "Dr. Martini-Award" of Hamburg (for investigations of

malononitrilamides and their relevance for organ transplantation)

2004 German Transplantation Society Young Investigator Award

2003 Doctoral Thesis Diploma of Excellency, Julius-Maximilian-University,

Wuerzburg, Germany

2002 German Society for Thoracic- and Cardiovascular Surgery (DGTHG):

Young Investigator Award for the Doctoral Thesis

Honors and Awards (Senior Author)

2014 International Society for Heart and Lung Transplantation (ISHLT)

Travelling Scholarship (Neofytou E)

2014 Vivien Thomas Award Finalist at the Scientific Sessions of the American

Heart Association (AHA) (Wang D)

2014 International Society for Heart and Lung Transplantation (ISHLT)

Travelling Scholarship (Wang D)

2013 Volker-Bay-Award for the Doctoral Thesis in Surgery (Hua X)


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2013 Basic Science Mentee/Mentor Award of the TTS (The Transplantation

Society) (Mentee: Guihaire J; Mentor: Schrepfer S)

2013 Else Kröner Fresenius Exzellenzstipendium (Deuse T)

2012 Basic Science Mentee/Mentor Award of the TTS (The Transplantation

Society) (Mentee: Hua X; Mentor: Schrepfer S)

2012 Travel Grant of the University Hamburg to present at the ISHLT

(International Society for Heart and Lung Transplantation) meeting in

Prague (Stubbendorff M)

2012 Philip K. Caves Award Finalist at the ISHLT (International Society for

Heart and Lung Transplantation) (Hua X)

2012 German Society for Thoracic- and Cardiovascular Surgery (DGTHG):

President`s Top Choice Award (Deuse T)

2011 Werner-Otto-Stipend for the Doctoral Thesis (Boeddinghaus J)

2011 Kaltenbach-Doktorandenstipend of the “Deutsche Herzstiftung” for the

Doctoral Thesis (Ricklefs F)

2011 Bionnale Speed Lecture Award, 2nd prize (Gossler T)

2010 Poster Award of the German Society for Thoracic- and Cardiovascular

Surgery (DGTHG) (Grabosch A)

2010 Travel Grant of the University Hamburg to present at the joined

AST/ESOT meeting in Nice (Gossler T)

2010 Poster Award of the University Hamburg (Stubbendorff M)

2010 Philip K. Caves Award at the ISHLT (International Society for Heart and

Lung Transplantation) (Deuse T)

2009 Top ranked abstract in Basic Science at the Scientific Sessions of the

American Heart Association (AHA) (Deuse T)

2009 Basic Science Award ISHLT (International Society for Heart and Lung

Transplantation) ($ 40,000.-; Deuse T)

2009 ESOT Short Stay Award (Student Tang-Quan KR)

2009 INTEL Semi-finalist (Student Ransohoff JD)

http://www.smdailyjournal.com/article_preview.php?id=104149

2008 SIMR Jessica Saal Award Stanford University (Student Ransohoff JD)


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http://ctsurgery.stanford.edu/about/news/schrepfer_ransohoff.html

2008 Young Investigator Award ATC (American Transplant Congress,

Postdoctoral Fellow Velotta J)

2008 Basic Science Award ISHLT(International Society for Heart and Lung

Transplantation) ($ 40,000.-; Postdoctoral Fellow Itoh S)

2008 NewEra Cardiac Care Scholarship (Postdoctoral Fellow Itoh S)

2008 ZonMW Scholarship, Netherlands (Eur 60,000.-; Postdoctoral Fellow

Lijkwan M)

2007 Research Grant Med Scholars Program Stanford University (Med-

student Bartos J)

Professional Activities

American Heart Association (AHA), Council on Cardiovascular Surgery and Anesthesia

American Society of Transplantation (AST)

Cardiothoracic Surgery Network (CTSnet)

German Society for Thoracic- and Cardiovascular Surgery (DGTHG)

German Transplantation Society (DTG)

European Society for Organ Transplantation (ESOT)

The International Society for Heart and Lung Transplantation (ISHLT)

Reviewer for International Journals

Ann Thorac Surg

J Vasc Res

Stem Cell Dev

Transpl Immunol

Microsurgery


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Int J Cardiol

Transplantation

Circulation

European Journal of Pharmacology

PLos ONE

Drugs

European Journal of Internal Medicine

Stem Cells Translational Medicine

JoVe

Circ Res

Stem Cells Translational Medicine

Boards and Committees

since 2014 Editorial Board of “Transplantation”

since 2013 Editorial Board of “World Journal of Cardiology (WJC)”

Since 2012 Vice Chair, Scientific Council on Basic Science and Translational research,

ISHLT (International Society for Heart and Lung Transplantation)

since 2011 Guest Editor for Journal of Transplantation, Special Issue “Lung

Transplantation”

2010 Program Committee for Basic Science (ISHLT; International Society forHeart

and Lung Transplantation)

since 2009 Editorial Board of “World Journal of Stem Cells (WJSC)”

Invited Talks

2014 ISHLT 34th Scientific Sessions. “Debate with Sharon Hunt: CON: Stem Cells are

the Future of Advanced Heart Failure Therapy and Always Will Be” during the


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session “The Sexiest Controversies in End Stage Heart Failure and

Transplantation”.

2014 ISHLT 34th Scientific Sessions. “Update on Stem Cells in Transplant: The Good

and Bad” during the session “Lung Transplant Immunology: Recent

Advances”.

2012 German Cardiac Society (DGK), Basic Science Meeting. “Immunobiology of

engineered tissue – a translational approach” during the Session “Engineered

heart tissue from stem cells – ready for transplantation?”.

2012 23.European Students´ Conference in Berlin.“Development of new

immunosuppressive agents and new targets”.

2012 BSRT International Summer School on Innovative Approaches in Regenerative

Medicine in Berlin.“Transplant and Stem Cell Immunobiology”.

2012 Wilsede Workshop: Experimental and Clinical Transplantation. “Successful

grant writing and publishing”.

2012 Stem Cell Institute, Cedars-Sinai, LA (Prof. Marban). “Experimental Stem Cell

Research”.

2012 American Transplant Congress (ATC). “Kinase Inhibitors of Cardiac Allograft

Rejection” during the Session “Kinases in Transplantation-From Outside to

Cellside”.

2012 Plenary Session at the ISHLT 32nd Annual Meeting & Scientific Sessions. “Stem

Cells - Are We There Yet?” during the Plenary session entitled “New

Horizons”.

2011 American Heart Association (AHA). “Mitochondrial biology – Similarities of

Transplant Vasculopathy and Tumorgenicity” during the session “CVS.714;

Advances in the Biology and Treatment of Transplant Vasculopathy”.

2011 BRST PhD Symposium.“Role of mesenchymal stem cells as biological drug

delivery systems and immunomodulators in regenerative medicine” during

the session “Healing Processes – Crossroads of Inflammation and

regeneration”.

2011 Stanford University, Cardiovascular Institute (CVI): Frontiers in Cardiovascular

Science. “Pluripotent stem cells and their immunobiology”.


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2011 ISHLT 31stAnnual Meeting & Scientific Sessions.“Heterotopic and orthoropic

tracheal transplantation” during the sunrise symposium “Experimental

Models of Lung Transplantation”.

2010 German Cardiac Society, Annual Meeting, Mannheim.Stem Cell Immunology –

Rejection versus Teratoma Formation.

2010 International Society for Heart and Lung Transplantation (ISHLT), 31st Annual

Meeting, San Diego. “What`s hot, what`s new – in stem cell transplantation”.

Activities

Support of Generation D (www.gemeinsam-anpacken.de), Immunological Forum Hamburg

(www.immunologie-hamburg.de), Cardiovascular Research Center Hamburg

(www.uke.de/forschungsverbuende/cvrc), Academics

(www.academics.de/blog/index.php/schrepfer), Transplant Immunology at Stanford

University (http://med.stanford.edu/labs/robert_robbins/tisci_group.html), Academia Net

(www.academia-net.de/alias/Profil/Prof-Dr-Sonja-Schrepfer/1033360), Jugend forscht

(www.jugend-forscht.de).

Patents

Title: "Method for Suppressing Graft Rejection following Lung Transplantation”.

Filing Date: September 25, 2007.

U.S. Application Number: 60/970, 128 (patent filed in the U.S. Patent and Trademark office).

Titel: “Overcoming the immunological barrier of allogeneic stem cell transplantation by gene

therapy”. In progress (2008) (Stanford Docket 07-309).


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Titel: ”Regulatory Macrophages as a Cell-based Immunomodulatory Therapy in Pulmonary

Hypertension and Right Ventricular Dysfunction”. Patent filed in the U.S. Patent and

Trademark office (13-294).

Title: “Inhibiting the development of intimal hyperplasia/re-stenosis by targeting

mitochondrial activity using dichloracetate (DCA)-different application forms”. Patent filed in

the U.S. Patent and Trademark office (S12-187).

Publications: Original Articles

1. Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M,

Gruenewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R,

Weissman IL, Schrepfer S. SCNT-derived ESCs with mismatched mitochondria trigger an

immune response in allogeneic hosts. Cell Stem Cell 2014.

DOI10.1016/j.stem.2014.11.003.

2. Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nagakami F,

Heymann HM, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten

A, Eriksson P, McConnell MV, Dalman RL, Tsao PS. miR-24 limits aortic vascular

inflammation and murine abdominal aneurysm development. Nat Commun.

2014;5:5214. doi: 10.1038/ncomms6214.

3. Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolanos JP, Rakovic A, Spin

J, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R,

Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein

C, Yeung A, Robbins RC, Tsao PS, Schrepfer S. DCA prevents restenosis in preclinical

animal models of vessel injury. Nature 2014;509(7502):641-4. Paper of the Month May

2014 of the “DZHK” (Deutsches Zentrum für Herz-Kreislauf-Forschung e.V.).


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4. Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC,

Schrepfer S. Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An

Introduction of Two Valid Models. J Vis Exp. 2014;14(87).

5. Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. The Ca(2+)-Activated K(+) Channel

KCa3.1 as a Potential New Target for the Prevention of Allograft Vasculopathy. PLoS

One. 2013;8(11):e81006.

6. Vrtovec B, Haddad F, Pham M, Deuse T, Fearon WF, Schrepfer S, Leon S, Vu T, Valantine

H, Hunt SA. Granulocyte colony-stimulating factor therapy is associated with a reduced

incidence of acute rejection episodes or allograft vasculopathy in heart transplant

recipients. Transplant Proc. 2013;45(6):2406-9.

7. Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J,

Schroeder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S. Immunological

properties of extraembryonic human Mesenchymal Stromal Cells derived from

gestational tissue. Stem Cells Dev. 2013;22(19):2619-29. (*Journal Cover)

8. Jungraithmayr W, Jang JH, Schrepfer S, Inci I, Weder W. Small Animal Models of

Experimental Obliterative Bronchiolitis. Am J Respir Cell Mol Biol. 2013;48(6):675-84.

9. Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F,

Reichenspurner H, Robbins RC, Schrepfer S. The potassium channel KCa3.1 as new

therapeutic target for preventing obliterative airway disease after lung transplant.

Transplantation 2013;95(2):285-292.

10. Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S,

Torre-Amione G, Haddad F, Wu JC. Effects of Intracoronary CD34+ Stem Cell

Transplantation in Nonischemic Dilated Cardiomyopathy Patients: 5-Year Follow-Up. Circ

Res. 2013; 112(1):165-73. (*Journal Cover and Accompanied Editorial)

11. Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J,

Streichert T, Reichenspurner H, Robbins RC, Schrepfer S. Significant reduction of acute


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cardiac allograft rejection by selective JAK1/3-inhibition using R507 and R545.

Transplantation 2012;94(7):695-702. (*Journal Cover)

12. Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C,

Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S. Human Internal Mammary

Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development

of In-Stent Restenosis. J Vis Exp. 2012;(63):e3663.

13. Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer

S, Evans SM, Carrier L, Eschenhagen T. Localization of islet-1-positive cells in the healthy

and infarcted adult murine heart. Circ Res. 2012;110(10):1303-10.

14. Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann

T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. HLA I knockdown human

embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.

Circulation 2011;124(11 Suppl):S3-9.

15. Duske H, Sputtek A, Binder T, Kröger N, Schrepfer S, Eiermann T. Assessment of

physiologic natural killer cell cytotoxicity in vitro. Hum Immunol. 2011;72(11):1007-12.

16. Deuse T, Seifert M, Tyan D, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD,

Reichenspurner H, Robbins RC, Schrepfer S. Immunobiology of naïve and gene-tically-

modified HLA I knockdown human embryonic stem cells. J Cell Science 2011;124:1-9.

(*Accompanied Editorial)

17. Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller

OJ, Kleinschmidt JA, Trepel M. Peptide ligands incorporated into the threefold spike

capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo. PLoS One.

2011;6(8):e23101.

18. Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H,

Robbins R C, Eschenhagen T, Schrepfer S. Bioluminescence Imaging for Assessment of

Immune Responses Following Implantation of Engineered Heart Tissue (EHT). J Vis Exp.

2011;(52).


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19. Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins

RC, Fischbein MP. Prevention of transplant coronary artery disease by prenylation

inhibitors. J Heart Lung Transplant. 2011;30(7):761-9.

20. Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk

HD, Reichenspurner H, Robbins RC, Schrepfer S. Immunogenicity and

immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell

Transplant. 2011;20(5):655-67.

21. Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S.

Orthotopic aortic transplantation: a rat model to study the development of chronic

vasculopathy. J Vis Exp. 2010;(46).

22. Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC,

Mochly-Rosen D, Schrepfer S. Sustained inhibition of epsilon protein kinase C inhibits

vascular restenosis after balloon injury and stenting. Circulation. 2010;122(11

Suppl):S170-8.

23. Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-

Rosen D, Robbins RC, Schrepfer S. Non-volume-loaded heart provides a more relevant

heterotopic transplantation model. Transpl Immunol. 2010;23(1-2):65-70.

24. Hoffmann J, Glassford AJ, Doyle TC, Robbins RC, Schrepfer S, Pelletier MP. Angiogenic

effects despite limited cell survival of bone marrow-derived mesenchymal stem cells

under ischemia. Thorac Cardiovasc Surg. 2010;58(3):136-42.

25. Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. Heterotopic

and orthotopic tracheal transplantation in mice used as models to study the

development of obliterative airway disease. J Vis Exp. 2010;(35).

26. Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer

S. LAD-ligation: a murine model of myocardial infarction. J Vis Exp. 2009;(32).


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27. Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer

S. Mechanisms behind Local Immunosuppression Using Inhaled Tacrolimus in Preclinical

Models of Lung Transplantation. Am J Respir Cell Mol Biol. 2010;43(4):403-12.

28. Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W,

Ransohoff KJ, Robbins RC, Wu JC. Poor Functional Recovery After Transplantation of

Diabetic Bone Marrow Stem Cells in Ischemic Myocardium. J Heart Lung Transplant.

2009;28(11):1158-1165.e1.

29. Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen

T, Stein W, Wu JC, Robbins RC, Schrepfer S. Hepatocyte growth factor or vascular

endothelial growth factor gene transfer maximizes mesenchymal stem cell-based

myocardial salvage after acute myocardial infarction. Circulation. 2009;120(11

Suppl):S247-54.

30. Deuse T, Ikeno F, Robbins RC, Schrepfer S. Imaging in-stent restenosis: an inexpensive,

reliable, and rapid preclinical model. J Vis Exp. 2009;(31).

31. Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC,

Schrepfer S. A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection.

Transplantation. 2009;87(5):653-9.

32. van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH,

Robbins RC, Wu JC. Comparison of transplantation of adipose tissue- and bone marrow-

derived mesenchymal stem cells in the infarcted heart. Transplantation.

2009;87(5):642-52.

33. van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ,

Pearl J, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC. Comparison of different adult


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stem cell types for treatment of myocardial ischemia. Circulation. 2008;118(14

Suppl):S121-9.

34. Schrepfer S, Swijnenburg RJ, Govaert J, Cao F, Ransohoff K, Sheikh A, Haddad M,

Connolly A, Davis M, Robbins RC, Wu J. Immunosupressive therapy mitigates

immunological rejection of human embryonic stem cell xenographs. Proc Natl Acad Sci

U S A. 2008;105(35):12991-6.

35. Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu J. In Vivo

Imaging of Embryonic Stem Cells Reveals Patterns of Survival and Rejection Following

Transplantation. Stem Cells Dev. 2008;17(6):1023-9.

36. Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D,

Pelletier MP, Robbins RC, Schrepfer S. Novel Immunosuppression: R348, a JAK3- and

Syk-inhibitor, attenuates acute cardiac allograft rejection. Transplantation.

2008;85(6):885-92.

37. Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S.Prevention and Inhibition but not

Reversion of Chronic Allograft Vasculopathy by FK778. Transplantation. 2008;85(6):870-

7.

38. Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Bergow C, Pelletier MP,

Robbins RC, Schrepfer S. Introducing the first polymer-free leflunomide eluting stent.

Atherosclerosis 2008;200(1):126-34. (*Journal Cover )

39. Rempf C, Ritter A, Schrepfer S, Freitag M, Standl T, Gottschalk A. Failed induction of

heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier

oxyglobin(r). Artif Cells Blood Substit Immobil Biotechnol. 2008;36(1):34-44.

40. Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T.

Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of

nitroglycerin in human veins. FASEB J. 2008l;22(7):2561-8.


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41. Sheikh AY, Schrepfer S, Stein W, West J, Lombard J, Burdon T, Pinsker B, Pelletier MP.

Right atrial mass after primary repair of an atrial septal defect: thrombus masquerading

as a myxoma. Ann Thorac Surg. 2007;84(5):1742-4.

42. Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fischbein MP, Robbins

RC, Pelletier MP. Effect of inhaled tacrolimus on cellular and humoral rejection to

prevent posttransplant obliterative airway disease. Am J Transplant. 2007;7:1733–1742.

43. Schrepfer S, Deuse T, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP.

Techniques for experimental heterotopic and orthotopic tracheal transplantations –

When to use which model? Transpl Immunol. 2007;17(4):255-261.

44. Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP. Stem

cell transplantation: The lung barrier. Transplant Proc. 2007;39(2):573-6.

45. Schrepfer S, Deuse T, Pelletier MP, Fischbein MP, Robbins RC, Reichenspurner H. Is the

malononitrilamide FK778 better for the prevention of acute or chronic rejection?

Transplant Proc. 2007;39(2):569-72.

46. Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier

MP. Simplyfied protocol to isolate, purify, and culture expand mesenchymal stem cells.

Stem Cell Dev 2007;16(1):105-7.

47. Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC,

Pelletier MP. Experimental orthotopic tracheal transplantation: The Stanford technique.

Microsurgery. 2007;27(3):187-9.

48. Sydow K, Schrepfer S, Franzen O, Detter C, Willems S, Meinertz T, Reichenspurner H.

Coincidence of aortic valve stenosis and regurgitation and multiple cardiac papillary

fibroelastomas in a young male adult. J Thorac Cardiovasc Surg. 2007;133(2):564-5.


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49. Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP,

Robbins RC, Reichenspurner H. FK778 in experimental xenotransplantation – A detailed

analysis of drug efficacy. J Heart Lung Transplant. 2007;26(1):70-7.

50. Schrepfer S, Deuse T, SultanK, Münzel T, Schäfer H, Pelletier MP, Robbins RC,

Reichenspurner H. Restenosis development after mechanical injury: A new field of

application for Malononitrilamides? Cardiology. 2006;108(2):128-137.

51. Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H. The selective

estrogen receptor- agonist biochanin A shows vasculoprotective effects without

uterotrophic activity. Menopause. 2006;13(3):489-99.

52. Schrepfer S, Deuse T, Sydow K, Schafer H, Detter C, Reichenspurner H. Tracheal allograft

transplantation in rats: the role of different immunosuppressants on preservation of

respiratory epithelium. Transplant Proc. 2006;38(3):741-4.

53. Schrepfer S, Deuse T, Koch-Nolte F, Detter C, Reichenspurner H.FK778: New Cellular and

Molecular Mechanisms of Action. Transplant Proc. 2006;38(3):757-61.

54. Baldus S, RudolphV, Roiss M, Ito W, Rudolph T, Eiserich JP, Sydow K, Kubala L, Berglund L,

Schrepfer S, Deuse T, Risius T, Klemm H, Reichenspurner H, Meinertz T, Heitzer T.

Heparin increases endothelial nitric oxide bioavailability by mobilizing vessel-adherent

myeloperoxidase. Circulation 2006;113(15):1871-8.

55. Schrepfer S, Deuse T, Koch-Nolte F, Haddad M, Schwedhelm E, Böger E, Schäfer H, Detter

C, Reichenspurner H. Sirolimus and FK778: Two antiproliferative Immunosuppressants

with same efficiency but different mechanisms of action in a rat tracheal transplant

model. Transpl Int. 2006;19(4):310-8.


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56. Schrepfer S, Deuse T, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H,

Reichenspurner H. FK778 and tacrolimus prevent the development of obliterative

airway disease after heterotopic rat tracheal transplantation. J Heart Lung Transplant

2005; 24(11):1844-54.

57. Schrepfer S, Deuse T, Schafer H, Koch-Nolte F, Braendle W, Reichenspurner H. The

phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting

the reproductive system. Transpl Immunol. 2005;15(1):45-53.

58. Schrepfer S, Deuse T, Schafer H, Reichenspurner H. FK778, a novel immunosuppressive

agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft

survival. Transpl Int. 2005;18:215-20.

59. Schrepfer S, Deuse T, Reichenspurner H. The interaction between FK778 and tacrolimus

in the prevention of rat cardiac allograft rejection is dose-dependent. Transplantation.

2004;77:509-13.

60. Schrepfer S, Deuse T, Koch-Nolte F, Schäfer H, Böger R, Reichenspurner H. FK778

attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo

and in vitro studies. Transplantation 2004;78:71-77.

61. Schrepfer S, Deuse T, Reichenspurner H. New technique for chest opening in mice: U-

sternotomy. Microsurgery. 2003;23:274-5.

62. Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm D, Willems S, Lacour-Gayet F,

Reichenspurner H. Successful resection of a symptomatic right ventricular lipoma. Ann

Thorac Surg. 2003;76:1305-7.

63. Deuse T, Schrepfer S, Reichenspurner H. Immunosuppression with FK778 and

Mycophenolate mofetil in a rat cardiac transplantation model. Transplantation.

2003;76:1627-9.


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64. Deuse T, Lange V, Schrepfer S, Eigenthaler M, Walter U, Elert O. Correlation between

mononuclear infiltration and changes in VASP phosphorylation patterns after

heterotopic cardiac transplantation in the rat. Eur Surg Res. 2003;35:6-13.

65. Gulbins H, Schrepfer S, Uhlig A, Goldemund A, Oberhoffer M, Reichenspurner H, Meiser

B, Reichart B. Myoblasts survive intracardiac transfer and divide further after

transplantation. Heart Surg Forum 2002;5:340-4.

66. Gulbins H, Anderson I, Kilian E, Schrepfer S, Uhlig A, Kreuzer E, Reichart B. Five years of

experience with mitral valve homografts. Thorac Cardiovasc Surg 2002;50:223-9.

Publications: Others

1. Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and

Applications. Chapter 5: “Immunogenicity of Stem Cells”, 2012, p.96-112. Bookchapter.

2. Circulation: European Perspectives Highlights 2012. Circulation 2012;126:f145-f150.

3. Circulation: European Perspectives in Cardiology. Article about the TSI-Lab (Schrepfer S)

which is funded by the German Heisenberg Program. Circulation 2012, 125:f37-f47.

4. Spitzenforschung Medizin: “Immunbiologie embryonaler Stammzellen”, 2009, p.2-10.

5. Laborwelt: “Tumorigenität, Überleben und Migration von Stammzellen”, 2009, 4/10.

Jahrgang, p.16-19.

Main Research Interests

Transplant Immunology: Mechanisms involved in allogeneic acute and chronic graft

rejection; Development of new immunosuppressive agents for heart and lung

transplantation; Inhaled immunosuppression after lung transplantation to prevent acute and


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chronic graft rejection; Mechanisms of immune tolerance (immunotolerance windows and

specific T cell modulation); Gene therapy for modulating immunogenicity of heart and lung

transplants; Developing novel humanized models to study chronic rejection of thoracic

transplants (transplant vasculopathy and bronchiolitis obliterans); The role of mtDNA in

allograft rejection.

Stem Cell Transplantation and Immunology: Immunobiology of various adult stem cells

from different sources (umbilical corld lining, bone marrow); pluirpotent stem cells

(embryonic stem cells, iPS cells) in cardiac repair; Immunogenicity pluripotent stem cells and

their rejection in allogeneic, xenogeneic, and humanized models; Gene therapy for stem cell

homing, and to prolong cell survival; Tissue engineering using pluripotent stem cells for

cardiac repair; Gene therapy to avoid immune responses after allogeneic transplantation of

stem cells and their derivates.

Vascular Biology: Cell-based strategies as novel therapeutic options in vascular diseases;

Revealing novel mechanisms in the development of intimal hyperplasia; Developing novel

humanized models to study the development of intimal hyperplasia and in stent re-stenosis;

microRNAs and vascular biology.

curriculum vitae - paul-martini-stiftung · 2019-04-21 · 2010 poster award of the university...

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