curriculum vitae surname: gesualdo title: md, fera first ......integrata per la diagnosi predittiva...

Curriculum Vitae Surname: Gesualdo Title: MD, FERA First Name: Loreto

Career/Employment Past 1987-1990 Research Associate, Institute of Pathology, CWRU, Cleveland, Ohio, USA 1994-2000 Staff physician, Institute of Nephrology, University of Bari 1997-1998 Visiting Professor, Department of Surgery, University of Pittsburgh 2000-2001 Associate Professor of Nephrology, University of Bari and Renal Division Chief, “Umberto I” Hospital, Altamura 2001-2003 Associate Professor of Nephrology, Chief of the Renal, Dialysis and Transplantation

Unit, University Hospital of Foggia 2004-2007 Director of the Centre of Excellence “BIOAGROMED” for the application of Biotechnologies to Medicine and Food Quality 2003-2010 Full Professor of Nephrology, Chief of the Renal, Dialysis and Transplantation Unit, University Hospital of Foggia 2003-2010 Coordinator of the PhD Program “Molecular Medicine”, School of Medicine, University

of Foggia 2005-2010 Director of the Nephrology Resident Program, School of Medicine, University of

Foggia 2007-2010 Director, Department of Nephrology, Dialysis and Tranplantation, Daunia Area (DIAN) 2007-2010 Council member, Italian Society of Nephrology 2010-2015 Director of the Nephrology Resident Program, School of Medicine, University of Bari 2010-2015 Member, Steering Committee of Immunonephrology Working Group, ERA-EDTA 2012-2015 Council member, ERA-EDTA (European Society of Nephrology) PRESENT 2010-pres Full Professor of Nephrology, Chief of the Renal, Dialysis and Transplantation Unit, University Hospital “Policlinico” of Bari; 2015-pres Coordinator, Apulia Transplant Program 2015-pres Chairman, CME Committee, European Society of Nephrology (ERA-EDTA) 2015-pres President, Italian Society of Nephrology 2015-pres Dean, School of Medicine, University of Bari Honors, Awards and Grants Cum Laude Medical School Diploma, 1986; R.H. "Mike" Mohrman Research Fellowship, Kidney Foundation of Ohio, 1988-89; Italian Ministry of Public Education, Award 1988-1991; American Heart Association - Northeast Ohio Affiliate, Research Fellowship 1989-90; Kidney Foundation of Ohio, Research Grant 1989-90; "Young Investigator Scholarship" 22 July 1990, Tokyo, Japan; EDTA-ERA travel grant 1991, 1993, 1995; Gambro Fellowship, Lund, Sweden 1991-92; EDTA-ERA Junior Award 1992; CNR-NATO Fellowship 1997; NATO Collaborative Research grant; Baxter Extramural Grant, 1997-2000; Cassa di Risparmio di Puglia Foundation, Research Grant 2004-2005; Ministry of Health, Research Grant 2002-2015; PRIN MIUR, Research Grant 2002-2005; FIRB MIUR, Research Grant 2004-2008-2016; Remap (Erasmus+ KA grant: 2016-2018); Beat-DKD (IMI2, EU grant 2015-2020).

Membership: Italian Society of Nephrology; International Society of Nephrology; European Dialysis and Transplant Association; American Society of Nephrology; Renal Pathology Society. Publications: papers in PubMed more than 370 (Kidney International, New England Journal of Medicine, Journal of American Society of Nephrology, Journal Clinical Investigation, Journal of Immunology, Blood, Arterioscler Thromb Vasc Biol., Transplantation, Laboratory Investigation, Journal of Pathology, Journal of Experimental Medicine, American Journal of Kidney Diseases, Journal of Nephrology); number of communications to scientific meetings: more than 250; Books: 16. Total Impact Factor: more than 1500; Google Scholar: Total Citations: more than 14525, H-score: 60. Scopus: Total Citations: more than 10.181, H-score: 50. RG Score: 49.35. Short report of my accomplishments In this short report I would like to summarize my 30-year professional career from both the academic and medical point of view. Since 1987 I have dedicated myself with passion and tenacity to research, training and clinical practice. After spending three years at Case Western Reserve University, Cleveland, US, from 1987 to 1990, training in the field of renal immunopathology as a Research Associate, I returned to Italy where, at the University of Bari, I set up a research group that worked and produced scientific papers in the field of molecular biology applied to renal biopsy to elucidate the pathogenesis of renal fibrosis (1991-1996). This very fruitful period of my professional life has allowed me to be invited as a guest speaker to many national and international meetings. What is more, in this period I was able to put in place a team of highly motivated young researchers. As a visiting professor, in 1997-1998, I spent a training period at the University of Pittsburgh where I developed considerable expertise in the field of kidney cancer immunotherapy and renal transplant. Back to Italy, from 1999 to 2000 I continued my research work and clinical practice in Bari where I kept on training PhD and medical students. In 2001, I was appointed Chief of the Division of Nephrology, Dialysis and Transplantation Unit of the University of Foggia, Full Professor of Nephrology, and Coordinator of the “Molecular Medicine” PhD Program of the Medical School of the University of Foggia (2004-2010) and also Director of the Nephrology Resident Program of the Medical School of the University of Foggia, (2005-2010). The 10 years I spent in Foggia were very productive and saw me involved in many academic initiatives in my capacity as Prorector for Research and Chair of a Technological District. During the years in question I founded the “Bioagromed” Research Center where many young researchers, PhDs and medical students have received training in omics sciences. In 2010, I was back to the University of Bari, where I currently serve as the Chief of the Division of Nephrology, Dialysis and Transplantation Unit, as well as Coordinator of Regional Transplant Center (CRT) of Puglia and Dean of the Medical School of the University of Bari. I served as a Member of the Steering Committee of the Immunonephrology Working Group, ERA-EDTA (2010-2015), and as a ERA-EDTA Council Member (2012-2015). I am currently President of Italian Society of Nephrology (2016-pres) and Chairman of ERA-EDTA Committee for CME activities. Many of the PhD and medical students trained under my supervision have now become independent researchers. Over the last 30 years I have been either Coordinator or Principal Investigator of several international, national and regional project grants (NATO, PRIN , FIRB, Ministry of Health, AIFA and EU grants) collecting more than 20 million Euros. I have extensive research experience in renal disease, renal transplantation and renal cancer immunology in relation to inflammatory response, renal fibrosis, immunotherapy, regenerative medicine. My group has contributed to major developments in the field of renal fibrosis. In addition to clinical nephrology, my research efforts are also focused on experimental models of animal disease (IgA nephropathy). These studies allow us to explore the mechanisms underlying both development and course of glomerular and interstitial inflammation in renal disease. My recent research work aims to identify, by means of a “system biology” and a “Precision Medicine” approaches, biomarkers to be used to enhance diagnosis, prognosis and therapeutic outcomes in several chronic kidney diseases (renal transplant, diabetic nephropathy, IgA nephropathy, Membranous GN, ADPKD, Rare Diseases in Nephrology). I have published more than 370 papers in PubMed, I have given more than 250 national and international lectures and communications during scientific meetings, my total IF: >1,500; total Citations in Scopus 10.181; H-index: 50; and in Google Scholar total citations 14,525; h-index 60. I filed three patents and I have been honored with several awards. I am a member of the Editorial Board of “Giornale Italiano di Nefrologia”, “Journal of Nephrology”, “Internal and Emergency Medicine”, “Nephrology Dialysis and Transplantation”, “Journal of Proteomics Insights”. I have served and still serve as a "peer reviewer" for the following journals: “Journal of the American Society of Nephrology”; “Kidney International”; “Proteomics”; “Journal of Immunology”; “American Journal of Kidney

Diseases”; ”Nephrology Dialysis and Transplantation”; ”Nephron”; ”Clinical Nephrology”; ”Journal of Nephrology”; ”Internal and Emergency Medicine”, “PloS ONE”; ”Giornale Italiano di Nefrologia”. I have several national and international collaborations in the United States, France and Germany. Finally, I have organized many international meetings, including the International Summer School of Renal Pathology (ISSRP), a two-week intensive program for practicing renal pathologists and nephrologists with an interest in improving their knowledge and clinical diagnostic skills. WHAT OTHERS THINK OF LORETO GESUALDO Opinion Leader in Nephrology. Excellent speaker, teacher and tutor. Excellent organizational and managerial skills, as well as an aptitude for coordinating team work. Excellent human qualities, from generosity to team spirit, contagious enthusiasm. PARTICIPATION IN TV BROADCASTS UNO Mattina, Mattino 5, Tutta Salute, Medicina 33, Storie Vere and many others local and regional TV. HUMANITARIAN ACTIVITIES Direct commitment to the establishment of a renal pathology center and a dialysis unit in Mbarara, Uganda. Next mission in October 2018. ANVUR EVALUATION (DM 29 luglio, N. 602) Scopus parameters (23.05.2018)

06/D2-MED/14 number of articles last 10 years

number of citations last 15 years

H index last 15 years

Threshold Full Professor 38 1174 18 Loreto Gesualdo 203 6506 37 Threshold Commissioner 65 1490 22 Loreto Gesualdo 203 6506 37 GRANTS ONGOING

Funding Source

Project Title

Acronymous Project code

Start Duration (months)

Total Budget (Euros)

DETO Budget (euros)

Commissione Europea

Horizon 2020

IMI2

Biomarker Entreprise to Attack

DKD

BEAT-DKD 115974 2016 60 29.421.038 620.000

Commissione Europea

ERASMUS + - call 2016 KA2

partenariati strategici

Renal Molecular Pathologist network

REMAP 2016-1-IT02-KA203-024318

2016 36 390.632

80.643

Ministero della Salute

Bando Ricerca

Finalizzata

SALt lowering by Urine sodium self-measurement Trial in Chronic Kidney

DiseasE

SALUTE-CKD

2016 36 443.340

31.000

MISE

Horizon 2020

Piattaforma innovativa e integrata per la diagnosi predittiva del rischio di progressione della malattia renale cronica, la terapia mirata e l’assistenza proattiva per i pazienti con

PRE.MED. F/050065/01-02/X32

2017 24 2.629.014 532.500

malattia genetica policistica autosomica dominante (MEDicina di PREcisione)

Commissione

Europea

2/PAC/2017 “Azioni per la

realizzazione di Summer

School promosse dalle Università

pugliesi”

Biomarkers, Technology Transfer and

Product Innovation

BIOTRAIN 2018 4 21.252

19.320

AIFA Metformin versus Tolvaptan in adults

with Autosomal Dominant Polycystic

Kidney Disease (ADPKD): a phase 3a, independent, multi-centre, 2 parallel arms randomized

controlled trial

Metropolis AIFA-2016-02365060

2018 42 2.113.000 2.113.000

Regione Puglia

Innonetwork

Alimento funzionale a base di Lens

culinaris Tipico del territorio pugliese ed

innovativo per la Salute

ALTIS K2DTD75

2018 18 2.210.000

540.000

Regione Puglia

Innonetwork

Sistema di telemonitoraggio

integrato a casa del paziente con

patologie Cardio- Renali

SI-CARE H6GG787

2018 18 2.143.711

230.000

Regione Puglia

Innonetwork

Nuovi modelli di gestione

dell’aderenza terapeutica nel

paziente trapiantato di RENE

RENEW Y67LWN4

2018 18 425.000

60.000

Total Budget 39.796.987 3.687.003 GRANTS SUBMITTED Funding Source

Project Title

Acronymous Project code

Start Duration (months)

Total Budget

DETO Budget

MIUR

PON

Costituzione della biobanca del microbiota intestinale e

salivare umano: dalla disbiosi alla simbiosi

BIOMIS

ND ND 24 8.850.000

2.450.000

MIUR

PON

Identificazione di nuovi markers diagnostici e

prognostici del tumore del colon-retto: focus su

staminalita’, microambiente e metabolismo

PREMEDICOL ND ND 24 9.000.000 750.000

MIUR

PON

Sviluppo di Metodi Avanzati per la Medicina Di

Precisione

SMAPM

ND ND 24 10.000.000 610.000

Budget Totale

27.850.000 3.810.000

REFERENCES (last 10 years)

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Recent advances in the pathogenetic mechanisms of sepsis-associated acute kidney injury (2018) Journal of Nephrology, 31 (3), pp. 351-359. Document Type: Review Source: Scopus

2) Cosola, C., Rocchetti, M.T., Cupisti, A., Gesualdo, L. Microbiota metabolites: Pivotal players of cardiovascular damage in chronic kidney disease (2018) Pharmacological Research, 130, pp. 132-142. Document Type: Review Source: Scopus

3) Santangelo, L., Netti, G.S., Giordano, P., Carbone, V., Martino, M., Torres, D.D., Rossini, M., Di Palma, A.M., Gesualdo, L., Giordano, M. Indications and results of renal biopsy in children: a 36-year experience (2018) World Journal of Pediatrics, 14 (2), pp. 127-133. Document Type: Article Source: Scopus

4) Nigro, M., Viggiano, D., Ragone, V., Trabace, T., Di Palma, A., Rossini, M., Capasso, G., Gesualdo, L., Gigliotti, G. A cross-sectional study on the relationship between hematological data and quantitative morphological indices from kidney biopsies in different glomerular diseases (2018) BMC Nephrology, 19 (1), art. no. 62, . Document Type: Article Source: Scopus

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6) Cafiero, C., Gigante, M., Brunetti, G., Simone, S., Chaoul, N., Oranger, A., Ranieri, E., Colucci, S., Pertosa, G.B., Grano, M., Gesualdo, L. Inflammation induces osteoclast differentiation from peripheral mononuclear cells in chronic kidney disease patients: Crosstalk between the immune and bone systems (2018) Nephrology Dialysis Transplantation, 33 (1), pp. 65-75. Cited 1 time. Document Type: Article Source: Scopus

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9) Fortarezza, F., Serio, G., Rossini, M., Rossi, R., Fiore, G., Piscitelli, D., Battaglia, M., Gesualdo, L., Resta, L. To do or not to do kidney biopsy in pediatric donors to evaluate transplant eligibility? (2017) Pediatric Transplantation, 21 (8), art. no. e13074, . Document Type: Letter Source: Scopus

10) Mancini, E., Perazzini, C., Gesualdo, L., Aucella, F., Limido, A., Scolari, F., Savoldi, S., Tramonti, M., Corazza, L., Atti, M., Severi, S., Bolasco, P., Santoro, A., on behalf of the Italian Oxygen Saturation Study Group (SOGLIA) Intra-dialytic blood oxygen saturation (SO2): association with dialysis hypotension (the SOGLIA Study) (2017) Journal of Nephrology, 30 (6), pp. 811-819. Cited 3 times. Document Type: Article Source: Scopus

11) Sanna-Cherchi, S., Khan, K., Westland, R., Krithivasan, P., Fievet, L., Rasouly, H.M., Ionita-Laza, I., Capone, V.P., Fasel, D.A., Kiryluk, K., Kamalakaran, S., Bodria, M., Otto, E.A., Sampson, M.G., Gillies, C.E., Vega-Warner, V., Vukojevic, K., Pediaditakis, I., Makar, G.S., Mitrotti, A., Verbitsky, M., Martino, J., Liu, Q., Na, Y.-J., Goj, V., Ardissino, G., Gigante, M., Gesualdo, L., Janezcko, M., Zaniew, M.,


Mendelsohn, C.L., Shril, S., Hildebrandt, F., van Wijk, J.A.E., Arapovic, A., Saraga, M., Allegri, L., Izzi, C., Scolari, F., Tasic, V., Ghiggeri, G.M., Latos-Bielenska, A., Materna-Kiryluk, A., Mane, S., Goldstein, D.B., Lifton, R.P., Katsanis, N., Davis, E.E., Gharavi, A.G. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations (2017) American Journal of Human Genetics, 101 (5), pp. 789-802. Cited 1 time. Document Type: Article Source: Scopus

12) Vincenti, F., Fervenza, F.C., Campbell, K.N., Diaz, M., Gesualdo, L., Nelson, P., Praga, M., Radhakrishnan, J., Sellin, L., Singh, A., Thornley-Brown, D., Veronese, F.V., Accomando, B., Engstrand, S., Ledbetter, S., Lin, J., Neylan, J., Tumlin, J. A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis (2017) Kidney International Reports, 2 (5), pp. 800-810. Cited 4 times. Document Type: Article Source: Scopus Access Type: Open Access

13) Gigante, M., Diella, S., Santangelo, L., Trevisson, E., Acosta, M.J., Amatruda, M., Finzi, G., Caridi, G., Murer, L., Accetturo, M., Ranieri, E., Ghiggeri, G.M., Giordano, M., Grandaliano, G., Salviati, L., Gesualdo, L. Further phenotypic heterogeneity of CoQ10 deficiency associated with steroid resistant nephrotic syndrome and novel COQ2 and COQ6 variants (2017) Clinical Genetics, 92 (2), pp. 224-226. Cited 2 times. Document Type: Letter Source: Scopus

14) Panichi, V., Rocchetti, M.T., Scatena, A., Rosati, A., Migliori, M., Pizzarelli, F., Gesualdo, L., REDERT Study group, Giusti, R., Ferro, G., Malagnino, E., Capitanini, A., Piluso, A., Conti, P., Bernabini, G., Caiani, D. Long term variation of serum levels of uremic toxins in patients treated by post-dilution high volume on-line hemodiafiltration in comparison to standard low-flux bicarbonate dialysis: results from the REDERT study (2017) Journal of Nephrology, 30 (4), pp. 583-591. Document Type: Article Source: Scopus

15) Scrutinio, D., Conserva, F., Passantino, A., Iacoviello, M., Lagioia, R., Gesualdo, L. Circulating microRNA-150-5p as a novel biomarker for advanced heart failure: A genome-wide prospective study (2017) Journal of Heart and Lung Transplantation, 36 (6), pp. 616-624. Cited 2 times. Document Type: Article Source: Scopus

16) Caloro, G.A., Spinelli, M., Campobasso, N., Esposito, T., Gesualdo, L., Montinaro, V. Clinical manifestations and therapeutic perspectives in tuberous sclerosis, a rare multi-organ genetic

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disease with renal involvement (2017) Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 34 (3), pp. 7-17. Document Type: Article Source: Scopus

17) Cupisti, A., D’Alessandro, C., Gesualdo, L., Cosola, C., Gallieni, M., Egidi, M.F., Fusaro, M. Non-traditional aspects of renal diets: Focus on fiber, alkali and Vitamin K1 intake (2017) Nutrients, 9 (5), art. no. 444, . Cited 3 times. Document Type: Article Source: Scopus

18) Regolisti, G., Maggiore, U., Cademartiri, C., Belli, L., Gherli, T., Cabassi, A., Morabito, S., Castellano, G., Gesualdo, L., Fiaccadori, E. Renal resistive index by transesophageal and transparietal echo-doppler imaging for the prediction of acute kidney injury in patients undergoing major heart surgery (2017) Journal of Nephrology, 30 (2), pp. 243-253. Document Type: Article Source: Scopus

19) Spinelli, A., Sharma, A., Villa, G., Samoni, S., Ramponi, F., Brocca, A., Brendolan, A., Chiaramonte, S., Castellano, G., Gesualdo, L., Ronco, C. Rationale for the Evaluation of Renal Functional Reserve in Living Kidney Donors and Recipients: A Pilot Study (2017) Nephron, 135 (4), pp. 268-276. Cited 2 times. Document Type: Article Source: Scopus

20) Bevilacqua, V., Pietroleonardo, N., Triggiani, V., Brunetti, A., Di Palma, A.M., Rossini, M., Gesualdo, L. An innovative neural network framework to classify blood vessels and tubules based on Haralick features evaluated in histological images of kidney biopsy (2017) Neurocomputing, 228, pp. 143-153. Cited 3 times. Document Type: Article Source: Scopus

21) Rossi, L., Gesualdo, L. Diabetic nephropathy and cardiovascular risk (2017) Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 34, pp. 104-118. Cited 1 time. Document Type: Review Source: Scopus


22) Sabatino, A., Regolisti, G., Cosola, C., Gesualdo, L., Fiaccadori, E. Intestinal Microbiota in Type 2 Diabetes and Chronic Kidney Disease (2017) Current Diabetes Reports, 17 (3), art. no. 16, . Cited 7 times. Document Type: Review Source: Scopus

23) Hanna, M.H., Dalla Gassa, A., Mayer, G., Zaza, G., Brophy, P.D., Gesualdo, L., Pesce, F. The nephrologist of tomorrow: towards a kidney-omic future (2017) Pediatric Nephrology, 32 (3), pp. 393-404. Document Type: Review Source: Scopus

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90) Kiryluk, K., Li, Y., Scolari, F., Sanna-Cherchi, S., Choi, M., Verbitsky, M., Fasel, D., Lata, S., Prakash, S., Shapiro, S., Fischman, C., Snyder, H.J., Appel, G., Izzi, C., Viola, B.F., Dallera, N., Del Vecchio, L., Barlassina, C., Salvi, E., Bertinetto, F.E., Amoroso, A., Savoldi, S., Roc

curriculum vitae surname: gesualdo title: md, fera first ......integrata per la diagnosi predittiva...

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