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CURRICULUM VITAESelva Baltan, MD, PhD

March 2016

CITIZENSHIP: USA

WORK ADDRESS: Department of Neurosciences, NC/30 Lerner Research Institute Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195-0001 Tel: (216) 444-3972 Fax: (216) 444-7927 Email: [email protected] Website: http://www.lerner.ccf.org/neurosci/baltan/

EDUCATION

1987 - 1984 BSc., Ankara Ataturk Anadolu High School, Ankara, Turkey (with Honors)

1984 - 1990 M.D., Hacettepe University (English Curriculum) Ankara, Turkey1994 - 1998 Ph.D., McGill University, Montreal, Canada

PROFESSIONAL APPOINTMENTS

1998 – 2001 Postdoctoral Fellowship, Department of Neurology, Washington University, St. Louis, MO

2001 – 2003 Senior Postdoctoral Fellowship, Department of Neurology, University of Washington, Seattle, WA

2003 - 2005 Acting Assistant Professor, Neurology Dept, UW, Seattle, WA2005 - 2010 Assistant Professor, Neurology Dept, UW, Seattle, WA2010 - 2011 Associate Professor, Neurology Dept, UW, Seattle, WA2011 – Present Assistant Staff, Department of Neurosciences, Lerner Research

Institute, Cleveland Clinic Foundation, Cleveland, OH2012-present Associate Professor, Dept. of Molecular Medicine, Case Western

Reserve University, Cleveland, OH .2014- Associate Staff, Department of Neurosciences, Lerner Research

Institute, Cleveland Clinic Foundation, Cleveland, OH

CERTIFICATION and LICENSURE

1989-1994 Medicine, Turkey

HONORS AND AWARDS

1984 Honors List, Graduated as the 3rd from Ankara Ataturk Anadolu High School

1984 - 1990 Hacettepe Medical School English Curriculum Scholarship 7/18/2011 of 29

mailto:[email protected]


March 2016 1986 Leiden Academic Hospital Medical Clerkship Award in Internal Medicine1994 - 1998 Hacettepe University and Turkish Higher Educational Council Post-

Graduate Scholarship1997 First Prize, McGill University Third Annual Physiology Day1997 Quebec and French Community of Belgium for the Improvement of

Technology Grant1998 McGill University, Alma-Mater Student Travel Grant1997 - 1998 Medical Research Council of Canada Scholarship1999 McDonnell Center for Cellular and Molecular Neurobiology Fellow2000 - 2002 American Heart Association Heartland Stroke Fellow2006 American Heart Association, Pacific Northwest Affiliate, Featured

Scientist.2007 Lifeline Column, The Lancet Neurology, November 2007 2009 Gordon Conference Invited Speaker, (Glia) March 2009, Ventura, CA2010 Gordon Conference Invited Speaker, (Myelin) Feb 2010, Ventura, CA2011 Keystone Meeting Invited Speaker, (Genetics, Immunology and Repair

in Multiple Sclerosis) Feb 2011, Taos, NM.2011 EuroGlia Meeting invited Speaker, Introductory Course, Prague, Czech

Republic, September 2011. 2011 Organizer of the First International Stroke Meeting, Antalya, Turkey

September 29-October 3, 2011. www.turkey-stroke2011.org

PROFESSIONAL SOCIETY AFFILIATIONS

1991-present Turkish Society of Physiological Sciences, Member1994-1998 Canadian Physiological Society, Member1994-1996 Executive Member, McGill University Physiology Student Association1996-1998 President, McGill University Physiology Student Association1996-1998 Physiology Councilor, McGill University Postgraduate Student Society1994-present Member, Society for Neuroscience2004-2008 Member, American Stroke Association, Council on Stroke2004-present Member, Turkish-American Scientists and Scholars Association

(TASSA), Medical Council 2012-present Council Member, Membership Committee for American Society for

Neurochemistry (ASN).

PROFESSIONAL SERVICE

Ad Hoc Journal Review

2002-present Glia 2002-present Stroke 2003-present Journal of Neurophysiology 2005-present Experimental Neurology 2005-present Neuropharmacology 2006-present Neurobiology of Disease 2006-present Neurochemistry International 2006-present J of Cerebral Blood Flow and Metabolism

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http://www.turkey-stroke2011.org/


March 2016 2007-present J of Neurochemistry 2007-present Neuroscience Letters

2008-present Journal of Neuroscience Research 2008-present Aging Cell 2009-present Journal of Comparative Physiology2009-present XXIVth Int. Symposium on Cerebral Blood Flow, Metabolism and

Function 2010-present Neuroscience2010-present Brain Research Bulletin2010-present American Society for Neurochemistry2011-present Journal of Neuroscience2011-present Canadian Journal of Physiology and Pharmacology 2011-present Synapse2011-present Neuron Glia Biology2012-present ASN2012-present Molecular Basis of Disease2012-present Journal of Comparative Medicine2012-present Neurology2013-present Degenerative Neurological and Neuromuscular Disease2014-present Journal of Metabolic Brain Diseases2014-present JoVe2014-present American Journal of Physiology2014-present Neuropharmacology2015-present Frontiers in Science2015-present Journal of Neurological Sciences2015-present Journal of Muscle and Nerve

GRANT REVIEW/STUDY SECTION MEMBERSHIP

2009 Welcome Trust Project Grants, United Kingdom2009 Multiple Sclerosis Society of Canada Scientific Research Council,

Canada.2011 Multiple Sclerosis Research Australia Scientific Committee.

2014(June) National Institute of Health, Ad Hoc Reviewer, Neural Oxidative Metabolism and cell death (NOMD) Study Section.

2015-present National Institute of Health, Ad Hoc Reviewer, Brain Injury and Neurovascular Pathology (BINP) Study Section.

2016- National Institute of Health, Ad Hoc Reviewer, Cellular and Molecular Biology of Glia (CMBG) Study Section.

COMMITTEE SERVICE:

1. National:

American Heart/Stroke Association

Advocate and American Heart Association Representative, Capitol Hill, NIH Funding Approximation Discussions with;

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March 2016 Senator Patty MurraySenator Maria Cantwell Congressmen Jim McDermottCongressman Brian BairdCongressman Dave ReichertMarch 10 2010, Washington DC

University of Washington

Medical School Councilor: Faculty Council for Women in Academia. First mandate 2005-2008, Second Mandate 2008-2011

Science Representative: American Heart Association, Pacific Northwest Heart Walk, 2007

Member: Dean’s Standing Committee on Women in Medicine: 2009-2011

Member: Women’s Center Review Committee on behalf of the Provost Office, 2009.

Cleveland Clinic Innovations

Peer review Committee Member 2014: Providing technical and clinical feedback about early stage technology to develop

commercially viable technologies.

LRI Postdoctoral Oversight Committee

2014-2017 Neurosciences Department representative and Member

Elsa Albrecht Research Achievement Award

2014-present Award Selection Committee Member

Lerner Research Institute Research Day Bumpus Award

2014- present Award Selection Committee Member

Lerner Research Institute Career Development Workshop

May 19 2016 Panelist for “The early years; how to survive and thrive”

Search Committee for Center for Excellence- Neurodegenerative DiseasesMellen Center and Cleveland Clinic Foundation2015-present Member

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March 2016

ASN Symposium/session Organizer:

American Society for Neurochemistry (ASN) 46th Annual MeetingMarch 14-18, 2015 Atlanta, Georgia.Session Title: Stroke and Mitochondria

2. International

Mitsubishi Pharma, Tokyo, Japan

Confidential Investigator, The effects of Ederavone on white matter stroke, 2005-present.

Meeting Organizer: First International Stroke Meeting, Antalya, Turkey Sept 29-Oct2, 2011www.stroke-turkey2011.org

Symposium/session Organizer:

International Stroke Meeting February 2013 Honolulu, HIWhite Matter Injury in StrokeSpeaker

EDUCATIONAL/TEACHING ACTIVITIES:

Teaching:

Teaching Assistant: Neurophysiology Teaching Assistant, McGill University, Montreal, QC, Canada, 1994-1998

ORALB 575, Winter Quarter 2007, Department of Dentistry, University of Washington, Seattle, WA

Cleveland Clinic LRI Molecular Medicine PhD Program, MMED 415 Biology; Introduction to Neuro-Glia. A new course organized for this curriculum, LRI, CCF, Cleveland OH, November 2011- present.

Cleveland Clinic LRI Molecular Medicine PhD Program, Introduction to Human Physiology and Disease- Stroke. LRI, CCF, Cleveland OH August 2012-present.

Cleveland Clinic LRI Molecular Medicine PhD Program, MMED 410 Human Physiology- Neuroscience Section.

August 2014.

Basic Science Preceptor for Cleveland Clinic Lerner College of Medicine:

Anne Runkle, CCLCM 2012.

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http://www.stroke-turkey2011.org/


March 2016 Clare Landefeld, CCLCM 2013.

Anna Faris, CCLCM 2014

Caroline Franke, CCLCM 2015

Cleveland Clinic Lerner College of Medicine: Molecular Mechanisms of Neuronal Cell Death and Stroke. Second Year Medical Student Classes in Neuroscience/Neurology Course.

Cleveland Clinic Lerner College of Medicine: Molecular Mechanisms of Neuronal Cell Death and Stroke. First Year Medical Student Classes in Neuroscience/Neurology Course.

2013-present LRI Speed Mentoring Event

Visiting Scientist:

January 2008 Neurogenetics Department, Max Planck Institute, Goettingen, Germany.May 2009 Neurogenetics Department, Max Planck Institute, Goettingen, Germany.January 2010 Neurogenetics Department, Mac Planck Institute, Goettingen, Germany.

Trainees:

Undergraduate Student:

1999-2000 Ariel-Lyons Warren, Undergraduate student, Ladue Horton Watkins High School, St Louis, MO.

2001-2002 Megan Weydt, Undergraduate Student (Honors), Neurobiology, UW, Seattle, WA.

2004-2005 Andrew Pena, Undergraduate Student, Department of Physiology and Bipohysics UW, Seattle, WA.

2004 Elaine F. Besancon, Undergraduate Student (Honors), Pre-Med, Neuroscience, Harvard University, Boston, MA.

2004-2005 Desiree Willis, Neurobiology and Technical Communication (Honors), Undergraduate Student, UW, Seattle, WA

2005 James Meabon, Undergraduate Student, Department of Physiology and Biophysics, Undergraduate Student, UW, Seattle, WA.

2012-2014 Jane Zaleski, John Carroll University, Cleveland, OH2012-2013 Ryan Teknipp, John Carroll University, Cleveland, OH2013-2015 Katherine Stahon, John Carroll University, Cleveland, OH2014 Britney Scott, Oakwood University, Alabama.2014 Harun Karakayaoglu, Hacettepe University, Ankara, Turkey2014 Grace Yi, Yale University, New Haven, MA, USA2014-2015 Shelby Griffith, John Carroll University, Cleveland, OH2014 Cansu Ayvacioglu, Hacettepe University, Ankara, Turkey2014-2015 Kelsey Cobourn, Georgetown University, Washington DC, USA.2015 Alison Herman, Princeton University, New Jersey, NY, DC2015 Karis Arnold, Oakwood University, Alabama.2015 Stephen Politano, John Carroll University, Cleveland, OH

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March 2016 2015 Brandon Parr, John Carroll University, Cleveland, OH2015 Danielle Aquila, Ohio State University, Columbus OH.

Technical Personnel:

1998-2001 Olga Strots, Lab manager and technician, Department of Neurology,

Washington University, St. Louis, MO 2006-2007 Brianna (Burke) Mbow, Lab Technician, Lab Manager, Department of

Neurology, UW, Seattle, WA. 2008-2009 Amelia Bachleda, Lab Technician, Lab Manager, Department of Neurology,

UW, Seattle, WA.2012-2013 Milana Leygerman, Lab Technician, Neurosciences Department, LRI, CCF,

Cleveland OH.

Rotating Students:

2012 Sabina Bhatta, Kent State University, PhD Student, Biomedical Sciences

2012 Anne Runkle, CCLCM Medical Student2013 Clare Landefeld, CCLCM Medical Student2013 Katherine Stanton, John Carroll University, Cleveland, OH

Award: 2014 Second Place, Research Student Poster Session, Cleveland Clinic, Lerner Research Institute.

Poster Title: Age-dependent modifications of axons, mitochondrial dynamics, and Ca2+ homeostasis underlie the vulnerability of aging white matter to ischemia

Award: 2015 Second Place, Celebration of Scholarship, John Carroll University, Cleveland, OH.

Poster Title: Changes in axon-myelin structure, mitochondrial dynamics, and Ca homeostasis underlie increased vulnerability of aging axons to ischemia

2014 Shelby Griffith, John Carroll University, Cleveland, OH2014 Britney Scott, Oakwood University, Alabama.2015 Brandon Parr, John Carroll University, Cleveland, OH2015 Stephen Politano, John Carroll University, Cleveland, OH

Graduate Student:

2008-2010 Aiman Saab, Graduate Student, Max Planck Institute of Experimental Medicine Department of Neurogenetics, Goettingen, Germany

2012-present Sabina Bhatta, Kent State University, Biomedical Sciences, Kent OH

Award: 2013 Neurological Institute Research Day Poster and Scientific Winner.

Fellowship Seminar: Impaired synaptic plasticity in Alzheimer’s disease, Dec 11 2013.

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March 2016 Postdoctoral Fellow:

2013-present: Chintha Bastian, Postdoctral fellow, Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

Fellowship Seminar: Iso-form specific NOS inhibition protects white matter against ischemic injury in an age-dependent manner. Feb 11, 2014.

Award: 2014 CCF Neurological Institute Research Day Postdoctoral Scientific Winner

Award: 2015 Bumpus Basic Science Award: Nitric oxide synthase contributes to the increased vulnerability of aging white matter to ischemia.

CURRENT FUNDING:

Vulnerability of aging white matter to ischemiaNIA (NIH) R01AG033720 09/1/2010- 8/31/2016 (NCE)PI: Selva Baltan (45%)Total Direct Costs (2010-2016):$1,250,000

The major goal of this project is to determine if aging WM function can be improved in a model of ischemic injury by attenuating oxidative injury and by preserving mitochondrial integrity through blockade of age-specific excitotoxic pathways.

Defining targets for the treatment of delayed cerebral vasospasm after SAHNINDS (NIH) R01NS074997 07/01/2012-06/31/2017PI: Provencio, J Javier, PIRole: Co-PI (13 % effort)Total Direct Costs (2012-2017): $1,250,000

The goal of this research proposal is to investigate the role of neutrophils in the development of delayed neurologic deterioration (DND) after subarachnoid hemorrhage (SAH).

Hippocampal Demyelination and Cognitive DysfunctionNINDS (NIH) RO1 07/01/2013-06/31/2018PI: Bruce D. TrappRole: Co-PI (20 % effort)Total Direct Costs (2012-2017): $1,250,000

The goal of this proposal is to investigate how demyelination affects hippocampal function and whether remyelination restores it.

Stroke TherapyDHHS (NIH) RO1

08/15/2010-05/31/2016 (NCE)PI: Vinod Labhasetwar 7/18/2011 of 29


March 2016 Role: Collaborator (5 % effort)

Total direct costs (2010-2015): $1,250.000

The goal of this grant is that nano-SOD/catalase, would minimize damage from t-PA while retaining its thrombolytic activity to extend the window of treatment, inhibit neuroinflammation by neutralizing the deleterious effects of ROS, and promote neuronal repair.

Alcohol-induced neurogenesisNIH/NIAAA R01

09/05/2014-31/08/2019PI: Hoonkyo SuhRole: Consultant (unpaid)Total Direct Costs (2014-2019): $1,250.000

The goal of this grant is to characterize the alcohol-induced neurogenesis.

Rose Mary Kubik Gift

Stroke InitiativesPI:Selva Baltan

The goal of this gift is to support initiatives on stroke research

Pathogenesis of Neurological Disability in Primary Diseases of MyelinNINDS R35

1/12/2016-30/11/2014Bruce Trapp (PI)Role: Key Personnel (40%)

In this proposal, we will address three key questions. 1) How does myelin provide trophic support to axons? We propose that transfer of ATP substrates is the major mechanism by which myelin provides trophic support to axons. Disruption of this metabolic coupling in inherited myelin diseases induces mitochondrial pathology/degeneration in paranodal axoplasm, which causes axonal degeneration. 2) How does demyelination affect neurons and their synaptic connections? We propose that demyelination alters neuronal gene expression, modulates dendritic structure, and reduces neuronal viability; we further propose that remyelination will reverse these changes. 3) How does subpial cortical demyelination occur?

PENDING FUNDING:

Therapy for blast-induced traumatic brain injuryNIHPI: Vinod LabhasetwarRole: Co-PI (20 % effort)

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March 2016 The goal of this grant is to characterize the white matter injury after contusion injury and the impact of free radical scavenging in a rat model of traumatic brain injury.

Casein Kinase 2 signaling in axonal injuryNIHPIs:Sylvain Brunet and Selva BaltanRole: Multi-PI (15% Effort)This grant is now scored at 3%

The goal of this grant is to define whether CK2 signaling is involved in axonal injury

Pathogenesis of CNS InjuryNINDS R35 Vinod Labhasetwar (PI)Role: Key Personnel

In this proposal, we will address CNS injury mechanisms underlying traumatic brain injury, stroke and the response to nanodelivery of oxidative scavengers.

Vulnerability of aging white matter to ischemiaNIH/NIA R01PI: Selva BaltanCompetitive Renewal

Role of CK2 in axonal signalingNMSS IIRGPI: Selva Baltan

The goal of this project is to identify the mechanisms of OL preservation following inhibition of CK2 signaling as well as the impact of CK2 inhibition on axonal mitochondrial dynamics, function, and ultrastructure.

Stroke therapyNINDS (NIH) R01NS070896PI: Vinod LabhasetwarRole: Collaborator Competitive Renewal

PREVIOUS FUNDING:

Myeloid cells, aging and the metabolic syndromeNIH R21 07/01/2013-06/31/2015PI: Richard RansohoffRole: Collaborator (10 % effort)Total Direct Costs (2013-2015): $250.000

The goal of this grant is to test the memory function in aging mice after blocking innate immune 7/18/2011 of 29


March 2016 reactions of myeloid cells to reduce metabolic syndrome.

Histone Deacetylases – therapeutic targets for functional restoration after strokeNIH (NINDS) 1R01 NS065319-01A1 (Murphy, Morrison) 04/1/2010–07/30/2011Role: Collaborator

These studies are designed to identify specific HDACs which account for the beneficial actions of enzyme inhibitors, the potential substrates and mechanisms responsible, and whether treatment of mice with a Class I HDAC inhibitor promotes long term recovery from cerebral ischemia.

International Society for Neurochemistry (ISN)PIs: Selva Baltan and Sean P. Murphy

Support for Small ConferencesFirst International Stroke Meeting, Antalya, TurkeyTotal Direct Costs (2011): $10,000

Aging and CNS white matter ischemic injuryAmerican Heart Association 0630197National Scientist DevelopmentPI: Selva BaltanTotal Direct Costs (2006-2010): $260,000

White Matter InjurySidney MS Research FundPI: Bruce B. RansomRole:Co-PITotal Direct Costs (2005-2010): $500,000

The goal of this study was to develop imaging techniques to visualize cellular and molecular components of white matter using optic nerves and corpus callosum slices from young animals.

Neurons and GliaNINDS (NIH) NS15589-26 PI: Bruce R. RansomTotal Direct Costs (2007-2012): $1,419,474The major goal of this project was to study the basic biology and function of hemi-channels in astrocytes.

Pathophysiology of CNS white matter injuryUnited Spinal Association 66-8431PI: Selva Baltan Tekkök Total Direct Funding (2004-2006): $130,000

The role of this project was to study the anoxic injury in optic nerves from young animals. The study revealed an unexpected resilience of axon function to lack of oxygen in optic nerves and corpus callosum slices which showed region-specific variation emphasizing the importance of optimum glucose concentration for in vitro preparations. 7/18/2011 of 29


March 2016

TRAINEE AWARDS:

Medical Research Council of Canada Scholarship ST-55391-AP008512PI: Selva (Baltan) Tekkök Total Direct Costs (1997-1999): $33,650

The goal of this project was to characterize the LTP induced by blockade of glycolysis with 2-deoxyglucose (2-DG), an anti-metabolite of hexokinase enzyme. The properties of 2-DG LTP were compared to electrically induced tetanic LTP.

Mechanisms of hypoxic ischemic injury in an acute brain slice modelNeurobiology Fellowship 97188MacDonnell Center for Cellular and Molecular NeurobiologyPI: Selva Tekkök Total Direct Costs (1999-2000): $35,000

The goal of this project was to develop acute coronal corpus callosum slices as a model to study white matter injury. The study proved corpus callosum slices as a new in vitro white matter model to monitor function and structure.

Ischemic white matter InjuryAmerican Heart/Stroke Association, Heartland Fellowship 0020638ZPI: Selva Tekkök

Total Direct Costs (2000-2002): $56,000

The goal of this project was to study the ischemic mechanisms of white matter injury in corpus callosum slices from young animals. The study revealed that glutamate mediated axon and glial injury via overactivation of AMPA/kainate receptors which was dependent on extracellular Ca2+.

Ca+2 during white matter injuryEastern Paralyzed Veterans Association 66-7131PI: Bruce R. Ransom Total Direct Costs (2003-2004): $70,000

The goal of this project was to study the role of Ca2+ during hypoglycemic injury in optic nerves from young animals. The role of glycogen and glycogen-derived lactate in maintaining axon function and the role astrocyte-axon lactate shuttle during glucose deprivation were characterized.

PEER REVIEWED PUBLICATIONS:

(Published as Selva Tekkök or Selva Baltan Tekkök)

1. Tekkök, S. and Dikmenoglu N. Physiological control mechanisms of arterial blood pressure. Hypertension Bulletin (Bayer), (32):38-47, 1993. (In Turkish).

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March 2016 2. Tekkök, S., Dikmenoglu, N., Tekkök, I.H., Balkanci, B, Yörukan Y, Andac, A.O. The effects of heparin treatment on the oxidative damage in experimental rat subarachnoid hemorrhage. Physiology Bulletin, 4(4): 93-97, 1993. (In Turkish).

3. Tekkök, S. and Dikmenoglu N. Comparative analysis of Na-pentobarbital and ketamine anesthesia: Physiology Bulletin, 3(4): 147-155, 1993. (In Turkish).

4. Tekkök IH, Tekkök S, Ozcan OE, Erbengi T, Erbengi A. Preventive effects of intracisternal heparin for proliferative angiopathy after experimental subarachnoid haemorrhage in rats. Acta Neurochir, 127: 110-117, 1994.

5. Tekkök, S. & Krnjevic, K. Long-term potentiation in hippocampal slices induced by temporary suppression of glycolysis. J. Neurophysiol. 74: 2763-2766, 1995.

6. Tekkök, S. and Krnjevic, K. Calcium-dependence of LTP induced by 2-deoxyglucose in CA1 neurons. J. Neurophysiol. 76: 2343-2352, 1996.

7. Zhao, Y.T., Tekkök, S., Krnjevic, K. 2-deoxy-D-glucose-induced changes in membrane potential, input resistance and EPSPs of CA1 hippocampal neurons. Can J Physio Pharm., 75: 368-374, 1997.

8. Krnjevic, K. Tekkök S, Medina I. and Zhao Y.T. Poor correlation between post-synaptic [Ca2+]i increases and LTP induced by 2-deoxyglucose in rat hippocampal neurons. Neurophysiology (Kiev) 29: 312-322, 1997.

9. Tekkök, S.B, Kriz, J., Padjen, A.L. and Krnjevic, K. Increased sensitivity of CA1 synaptic transmission to aglycemia in diabetic rats is age-dependent. Brain Research, 813:268-273, 1998.

10. Tekkök, S., Medina, I., Krnjevic, K. Intraneuronal [Ca+2] changes induced by 2-deoxyglucose in rat hippocampal slices. J Neurophysiol. 81:174-183, 1999.

11. Tekkök, S.B. and Krnjevic, K. Diabetes mellitus preserves synaptic plasticity in hippocampal neurons from middle-aged rats. Neuroscience. 91:185-191, 1999.

12. Godfraind, JM, Baltan Tekkök, S. and Krnjevic K. Hypoxia on hippocampal slices from mdx and mdx-3CV mice J Cereb Blood Flow Metab. 20(1): 145-52, 2000.

13. Tekkök S. and Goldberg MP. AMPA/Kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter. J of Neurosci 21: 4237-4248, 2001.

14.Tekkök, S., Godfraind, J.M., Krnjevic, K. Moderate hypoglycemia aggravates effects of hypoxia in hippocampal slices from diabetic rats. Neuroscience 113: 11-21, 2002.

15. Brown AM, Tekkök S and Ransom BR. Hypoglycemia and white matter: pathophysiology of axon injury and role of glycogen. Diabetes, Nutrition & Metabolism, 15(5): 290-294, 2002.

16.Ye ZC, Wyeth MS, Baltan- Tekkök S and Ransom BR. Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J of Neurosci, 23: 3588-3596, 2003. 7/18/2011 of 29


March 2016

17. Brown A, Baltan Tekkök S and Ransom BR. Glycogen regulation and functional role in mouse white matter. J of Physiol. 549: 501-512, 2003.

18. Baltan Tekkök S, Brown AM and Ransom BR. Axon function persists during anoxia in mouse optic nerve. J Cereb Blood Flow Metab 23:1340-1347, 2003.

19. Brown AM, Baltan Tekkök S and Ransom B. Energy transfer from astrocytes to axons: the role of CNS glycogen. Neurochem Int. 45:529-36, 2004.

20. Baltan Tekkök S and Ransom BR. Anoxia effects on the CNS function and survival: regional differences. Neurochem Res. 49:2163-2169, 2004.

21. Baltan Tekkök S, Faddis BT and Goldberg MP. AMPA/Kainate receptors mediate axonal morphological disruption in hypoxic white matter. Neurosci Letters, 382:275-279, 2005.

22. Baltan Tekkök S, Brown AM, Westenbroek R, Pellerin L and Ransom BR. Transfer of glycogen derived lactate from astrocytes to axons via specific monocarboxylate transporters support mouse optic nerve activity. J of Neurosci Res. 81:6424-652, 2005. (COVER ART of J of Neurosci Res Volume 81 Issue, 2005 )

23. Baltan Tekkök S, and Ransom BR. Regional differences in excitotoxic white matter injury. International Proceedings, May 2005.

24. Tekkok SB, Ye ZC and Ransom BRR. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J of Cereb Met Blood Flow, 27: 1540-52, 2007.Publications as Selva Baltan

25. Baltan S, Besancon EF, Mbow B, Ye, ZC, Hamner M, and Ransom BR. White matter vulnerability to ischemic injury increases with age due to enhanced excitotoxicity. J of Neuroscience 28:1479-89, 2008. (COVER ARTICLE , J Neuroscience Feb 6 Issue.28, 2008)

26. Baltan S, Inman D, Danilov C, Morrison R, Calkins DJ, Horner P. Metabolic vulnerability disposes retinal ganglion axons to dysfunction in a model of glaucomatous degeneration. J of Neuroscience 30:5644-5652, 2010.( COVER ARTICLE, J of Neuroscience April 21 Issue 30, 2010 )

27. Baltan S, Murphy P. S., Danilov A.C., Bachleda A and Morrison R. Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. J of Neuroscience 31:3990-3999, 2011.( COVER ARTICLE, J of Neuroscience March 16 Issue 31, 2011 )

28. Baltan S, Bachleda A, Morrison RS and Murphy SP. Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia. Translation Stroke Research June 4;2(3):411-423, 2011.

Most downloaded article.http://www.springer.com/biomed/neuroscience/journal/12975?hideChart=1#realtime

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http://www.springer.com/biomed/neuroscience/journal/12975?hideChart=1#realtime


March 2016 29. Baltan S. Class I histone Deacetylase Inhibitors preserve aging axon function. J of Neurochem. 123:108-115,2012. ( COVER ARTICLE, J of Neurochemistry November Issue 123, 2013 ).

30. Murphy SP, Lee RJ, McClean ME, Pemberton HE, Uo T, Morrison RS, Bastian C, Baltan S. MS-275, a class I histone deacetylase inhibitor protects the p53 deficient mouse against ischemic injury. J of Neurochem 129:509-515, 2014. COVER ARTICLE J of Neurochemistry 2014 .

31. Baltan S. Can lactate serve as an energy substrate for axons in good times and in bad, in sickness and in health. Metab. Brain Dis. Jul 19, 2014 (EPub Ahead of publication).

32. Baltan S. Excitotoxicity and mitochondrial dysfunction underlie age-dependent ischemic white matter injury. Adv Neurobiol. 11:151-170, 2014.

33. Baltan S. Can lactate serve as an emergency energy substrate for axons in good times and in bad, in sickness and in health? Metab. Brain Dis. 1:25-30, 2015.

34. Saab, AS, Tzvetavona*, ID, Baltan S*, Möbius W, Dibaj P, Kusch K, Goetze B, Trevisiol A, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Matute C, Löwel S, Hirrlinger J, Kirchhoff F, and Nave KA. Oligodendroglial NMDA receptors regulate axonal energy metabolism. Neuron (accepted, in print). * Co-second authors.

35. Baltan S. Age-specific expression and location of NMDA receptors on oligodendrocytes determine vulnerability of white matter to ischemia. Neuropharmacology September 2015 (Epub Ahead of print).

36. Provencio, JJ, Seerapu, H, Brunet, S, Swank, V, Khapre, R, Ransohoff, RM, Baltan,S. delayed deterioration associated with vasospasm after subarachnoid hemorrhage is mediated by NMDA receptors. Brain Beh and Imm. 2016 (Epub Ahead of Print).

37. Parpura V, Fisher ES, Lechleiter JD, Schousboe A, Waagepetersen HS, Brunet S, Baltan S, Verkhratsky A. (2016) Glutamate and ATP at the interface signaling and metabolism in astroglia: examples from pathology. Neuroche Res. (ePub ahead of print). PMID:26915104

38. Saab AS, Tzevetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Mobius W, Goetze B, Jahn HM, Hunag W, Steffens H, Schomburg ED, Perez-Smartin A, Perez-Cerda F, Bakhtiari D, Matute C, Lowel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA. Oligodendrocglial NMDA Receptors regulate glucose import and axonal energy metabolism. Neuron 16: 30176-3 (ePub ahead of print. PMID:27292539.

39. Stahon K, Bastian C, Griffith S, Grahame K, Brunet S, Baltan S. Age-related changes in axonal and mitochondrial ultrastructure and function render white matter more susceptible to ischemia (In Press).

40. Hu X, Hou H, He W, Ge Y, Yin X, Chinthasar B, Sylvain B, Baltan S* and Riqiang Yan*. BACE1 defficiency facilitates proliferation of Schwann cells. (Under revision).

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March 2016 41. Yin, X., Kidd, GJ. Ohno, N., Perkins GA., Ellisman M., Bastian, C., Brunet, S., Baltan, S., and Trapp, BD. Axonal degeneration in a mouse model of hereditary spastic paraplegia2. (Submitted).

To BE SUBMITTED MANUSCRIPTS:

1. Bastian C, Zaleski J, Brunet S, Baltan S. Isoform-specific NOS inhibition protects white matter against ischemic injury in an age-dependent manner.

2. Bastian C, Politano S, Brunet S, Baltan S. Mitochondrial dynamics in white matter stroke.

3. Landefeld, C., Rosenberg, PA,., Bastian C., Makinodan M., Corfas G., Baltan S. Oligodendrocytes support axon function via glutamate signaling through glutamate transporter (GLT-1) in a gender and age-specific manner.

BOOK CHAPTERS

1. Underhill SM, Baltan Tekkok S, Hasbani JM and Goldberg MP. Cellular mechanisms of white matter ischemia-what can we learn from culture models? 21st Princeton Conference on Cerebrovascular Disease Chan, P. ed., 2001.

2. Baltan Tekkök S and Ransom BR. Glial-neuronal interactions and signaling: an introduction. In Glia and Neuron Signaling (Hatton, G.I. and Parpura, V. eds) Kluwer Norwall, MA (Amsterdam, The Nederlands), 2004.

3. Brown AM, Baltan Tekkök S and Ransom BR. Metabolic Coupling Between Glia and Neurons In Glia and Neuron Signaling (Hatton, G.I. and Parpura, V. eds) Kluwer Norwall, MA (Amsterdam, The Nederlands) 2004.

4. Brown AM. Baltan S, and Ransom BR. Astrocyte Glycogen and Brain Metabolism. New Encyclopedia of Neuroscience. Elsevier Limited, Oxford (United Kingdom). (In press).

5. Ransom BR, Goldberg MP, Baltan S. Molecular pathophysiology of white matter anoxic-ischemic injury. Editors Choi DW, Mohr JP, Weir B, Grotta JC, Wolf PA Churchill Livingstone, Elsevier, Philadelphia, USA, 2011.

6. Baltan S. Age-dependent mechanisms of white matter injury after stroke. White Matter Injury after stroke and CNS disorders. Springer Translational Stroke book series. Editors Baltan S, Carmichael TS, Matute C, Zhang J. Springer, USA 2013 (2013).

7. Ransom BR, Goldberg MP, Baltan S. Molecular pathophysiology of white matter anoxic-ischemic injury. Editors Lo E, Grotta JC, Wolf PA Churchill Livingstone, Elsevier, Philadelphia, USA, 2015.

8. Baltan S. Excitotoxicity and mitochondrial dysfunction underlie age-dependent ischemic 7/18/2011 of 29


March 2016 white matter injury. Glutamate and ATP at interface of metabolism and signaling in the brain. Editors: Parpura V., Schousboe A., Verkhrastsky A. Springer, New York, NY, USA. 2014.

9. Brunet S, Bastian C, Baltan S. Ischemic White Matter Injury: An age-dependent process. Editors; Chen, J. and Zhang J. Springer, New York, NY, USA. (submitted).

INVITED PEER REVIEWED REVIEWS

1. Baltan S. Surviving anoxia: A tale of two white matter tracts. (Review). Critical Reviews in Neurobiology 18: 95-103, 2006. (Peer Reviewed).

2. Baltan S. Ischemic injury to white matter: An age-dependent process. The Neuroscientist, 15: 126-133, 2009. (Peer Reviewed).

3. Ransom BR. and Baltan S. Axons get excited to death! Annals of Neurol. 65: 120-121, 2009 (Letter to the Editor).

4. Baltan S, Morrison RS, Murphy SP. Novel protective effects of histone deacetylase inhibition on stroke and white matter ischemic injury Neurotherapeutics Special Issue (Guest Editors Basso, S and Ratan R.) Epigenetics and Therapeutics, July 23 2013 (Peer Reviewed).

Featured Article on MDLinx.comhttp://www.mdlinx.com/pharmacy/news-article.cfm/4741433/cerebral-ischemia--zn-dependent-histone-deacetylase--infarct--mitochondria--p53--aging

OTHER PUBLICATIONS

Book Editor

1. White Matter Injury after stroke and CNS disorders. Springer Translational stroke book

series. Editors: Baltan S, Carmichael TS, Mature C, Zhang J. Springer, USA 2013.

Special Issue Guest Editor (2016)

Stroke Research and Treatment (Selva Baltan, Yasemin Ozdemir, Ihsan Solaroglu, Ilknur Ay).

Art and Images

Cover Art Monday Booklet Cover Image for 2009 Society for Neuroscience Meeting, Chicago, 2009.

Portraits of the Mind Multi-Diolistic technique application to white matter, pages 110-111, Abrams Books, New York (USA), 2010.

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http://www.mdlinx.com/pharmacy/news-article.cfm/4741433/cerebral-ischemia--zn-dependent-histone-deacetylase--infarct--mitochondria--p53--aging

http://www.mdlinx.com/pharmacy/news-article.cfm/4741433/cerebral-ischemia--zn-dependent-histone-deacetylase--infarct--mitochondria--p53--aging


March 2016

Molecular Medicine PhD Program (MMED) Brochure Cover, LRI, CCF 2011.

American Society for Neurochemistry (ASN) 2012: “Dance of Neurons” Science as Art Category Winner for Metabolism and Cell and Molecular Biology.

Cover Art Wednesday Booklet Cover Image for 2012 Society for Neuroscience Meeting, New Orleans, 2012.

Society for Neuroscience iPad App Cover, 2012

Society for Neuroscience New Orleans Convention Center Decorations, New Orleans, 2012.

News

http://hurarsiv.hurriyet.com.tr/goster/printnews.aspx?DocID=21922181http://www.turizmhaberleri.com/haberayrinti.asp?ID=24094http://www.kasder.org.tr/tr/component/content/article/9-guencel/571-48-ulusal-noeroloji-

kongresihttp://www.antalyakorfez.com/haber-3717-C3%87a%C4%9F%C4%B1n%20hastal

%C4%B1klar%C4%B1%20tart%C4%B1%C5%9F%C4%B1lacak.html

ABSTRACTS

1. Dikmenoglu N, Baskurt O, Levi E, Tekkök S, Andac SO. The decrease in the red cell deformability after sulphur dioxide inhalation. Presented at the XVIIIth Annual Meeting of Turkish Physiological Society, Nov 3-5, 1992, Cappodocia, Turkey.

2. Tekkök S, Dikmenoglu N, Tekkök IH, Balkanci D, Andac SO. Effects of intracisternal heparin on oxidative damage caused by the subarachnoid haemorrhage model on the rats. Presented at the XIXth Annual Meeting of Turkish Physiological Society, Nov 9-13, 1993, Antalya, Turkey.

3. Dikmenoglu N, Tekkök S, Tekkök IH, Yorukan S, Andac SO. The comparative neuroprotective effects of Na-pentobarbital and ketamine anaesthesia. Presented at the XIXth Annual Meeting of Turkish Physiological Society, Nov 9-13, 1993, Antalya, Turkey.

4. Tekkök, S. & Krnjevic, K. Biphasic effects of 2-deoxyglucose on synaptic transmission in hippocampal slices. Can. J. Physiol. Pharmacol. 73:AXXX, 1994.

5. Krnjevic, K. and Tekkök, S. How does 2-deoxyglucose (DOG)-induced LTP compare with some other kinds of LTP. Soc. Neurosci. Abstr.21:261, 1995.

6. Tekkök, S. and Krnjevic, K. LTP can be induced in hippocampal slices by 2-deoxyglucose. Soc. Neurosci. Abstr.21:261, 1995.

7. Tekkök, S. and Krnjevic, K. Post-hypoglycaemic long-term potentiation in 7/18/2011 of 29

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http://www.kasder.org.tr/tr/component/content/article/9-guencel/571-48-ulusal-noeroloji-kongresi

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http://www.turizmhaberleri.com/haberayrinti.asp?ID=24094

http://hurarsiv.hurriyet.com.tr/goster/printnews.aspx?DocID=21922181


March 2016 hippocampus. Presented at the First Physiological Research Day, McGill University, May 1995, Montreal, Canada.

8. Tan, A.T., Tekkök, S., Krnjevic, K. Dantrolene (but not thapsigargin) prevents the long-term potentiation induced in CA1 region of rat hippocampal slices by 2-deoxyglucose (2DG). Soc. Neurosci. Abstrc. 22:1460, 1996.

9. Tekkök, S. and Krnjevic, K. 2-Deoxyglucose (2-DG)-induced LTP in hippocampal CA1 neurons requires Ca2+ released from internal stores. Soc. Neurosci. Abstr. 22:333, 1996.

10. Tekkök, S. and Krnjevic, K. Long-term potentiation induced by 2-deoxyglucose in CA1 neurons of rat hippocampal slices is Ca2+-dependent. J. Physiology. (London). 494p:P81-82, 1996.

11. Krnjevic, K. and Tekkök, S. Adenosine antagonists prevent the block of synaptic transmission produced by 2-deoxyglucose in rat hippocampal slices but not the subsequent LTP. J. Physiol (London). 495p:p52-53, 1996.

12. Tekkök, S. and Krnjevic, K. Le dantrolene supprime la potentialisation-a-long terme (PLT) induite par le 2-deoxyglucose (2-DG). Presented in the ACFAS Congress, May 15 1996, Montreal, Canada.

13. Tekkök, S. and Krnjevic, K. Dantrolene prevents the long-term potentiation Induced by 2-deoxyglucose in hippocampus. Presented in the Second Annual Physiology Research Day on May 24 1996, Montreal, Canada.

14. Tekkök, S., Medina, I. and Krnjevic, K. Intraneuronal [Cai] changes induced by 2-deoxy-D-glucose (2-DG) in rat hippocampal CA1 neurons. Presented in the Third Annual Research Day on May 23 1997, Montreal, Canada.

15. Krnjevic, K., and Tekkök, S. Curious properties of 2-Deoxyglucose-induced LTP of CA1 hippocampal neurons. Paul Feltz Memorial Meeting, Strasbourg, France, 1997.

16. Tekkök, S., Kriz, J., Padjen, A.L. and Krnjevic, K. Streptozotocin-induced diabetes mellitus preserves synaptic properties of hippocampal CA1 neurons in ageing rats. 2nd

17. Crotian Congress of Pharmacology with International Participation, Sept 9-13, 1997, Rijeka, Croatia.

18. Tekkök, S., Kriz, J., Padjen, A.L. and Krnjevic, K. Streptozotocin-induced diabetes mellitus increases sensitivity of CA1 neurons to lack of glucose in rat hippocampal slices. Can. J Diabetes Care Suppl 21: 17, 1997.

19. Krnjevic K. and Tekkök, S. LTP induced in hippocampal slices by deoxyglucose (2-DG) and occlusion of subsequent tetanic LTP both depend on the duration of 2-DG application. Can J Physio Pharm., 75: Axvii, 1997.

20. Tekkök, S., and Krnjevic, K. Long-tem potentiation induced by deoxyglucose in CA1 neurons of rat hippocampal slices is independent of protein kinase activity. Can J Physio Pharm., 75: Axvii, 1997.

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March 2016

21. Pivneva, T.A., Tekkök, S., Krnjevic, K. and Morris, M. Ultrastructural calcium changes induced by 2-deoxy-D-glucose (2-DG) in rat hippocampal slices. Soc. Neurosci. Abstrc. 23:310, 1997.

22. Tekkök, S, Medina, I., Ben-Ari, Y. and Krnjevic, K. 2-deoxyglucose (2-DG) Increases [Ca]i in rat CA1 neurons. Soc. Neurosci. Abstrc. 23: 310, 1997.

23. Krnjevic, K. and Tekkök, S. Are phosphorylating mechanisms involved in 2-deoxyglucose (2-DG)-induced LTP of CA1 neurons? Soc. Neurosci. Abstrc. 23: 310, 1997.

24. Padjen, A.L., Tekkök, S., Kriz, J and Krnjevic, K. Streptozotocin-induced diabetes causes age-dependent increase in sensitivity of CA1 neurons to aglycemia. Soc. Neurosci. Abstrc. 23: 310, 1997.

25. Tekkök, S. and Krnjevic, K. 2-deoxyglucose-induced long-term potentiation In CA1 neurons of rat hippocampal slices is sensitive to blockers of protein kinases. J. Physiol. (London) 501P: 86P 1997.

26. Krnjevic, K., Zhao, Y.T. and Tekkök, S. 2-deoxy-D-glucose induced LTP can be dissociated from changes in post-synaptic potential and input resistance of CA1 neurons. IUPS Congress, St. Petersburg, Russia, PO75.16, 1997.

27. Godfraind, JM, Tekkök, S. and Krnjevic K. Hypoxia on hippocampal slices from dystrophin and dystrophin isoforms-deficient mice. EWCBR, 1998.

28. Tekkök, S.B., Godfraind, J.M., and Krnjevic, K. 2-Deoxy-D-glucose LTP is impaired in hippocampal slices from mdx and mdx-3CV mice. Soc. Neurosci. Abstrc. 24: 1168, 1998.

29. Godfraind, JM, Tekkök, S. and Krnjevic K. Hypoxia on hippocampal slices from mdx and mdx-3CV mice. Soc. Neurosci. Abstrc. 24: 1953, 1998.

30. Krnjevic, K., Baltan Tekkök, S., Godfraind, J.M. Hypoxia on hippocampal slices from streptozotocin-induced diabetic rats. Soc. Neurosci. Abstrc. 24: 1168, 1998.

31. Baltan Tekkök, S. and Goldberg, M.P. Oxygen glucose deprivation causes AMPAR-mediated oligodendrocyte death in mouse brain slices. Soc. Neurosci. Abstrc. 25: 577. 1999.

32. Goldberg, M.P., Hasbani, M.J., Baltan Tekkök, S. Effects of oxygen-glucose deprivation on cortical axons. Soc. Neurosci. Abstrc. 25: 577, 1999.

33. Baltan Tekkök, S. Grutzendler J., Lichmann, J., Goldberg, M.P. Ischemic white matter injury in brain slices: a functional and structural study. Oral Presentation, 25th International Stroke Meeting, Feb 10-12, 2000, New Orleans.

34. Underhill, SM., Baltan Tekkök, S., and Goldberg, MP Hypoxic-ischemic oligodendrocyte injury in primary cultures and brain slices is mediated by AMPA/kainate receptor activation. Glia Meeting, May 20-24, Spain 2000.

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March 2016 35. Canzoniero LMT, Baltan Tekkök S, Goldberg MP and Choi DW. Zinc toxicity in hippocampal slices from adult mice. Soc Neurosci. Abstr. 26:763,2000.

36. Underhill, SM., Baltan Tekkök, S., Hyrc, KL., Yamada, KA., and Goldberg, MP. Role of calcium permeable AMPA receptors in oligodendrocyte excitotoxicity. Soc Neurosci. Abstr. 26: 2064, 2000.

37. Baltan Tekkök, S., Hyrc, KL., Underhill, SM. and Goldberg MP. Na2+ / Ca 2+ exchange blocker KB-R7943 protects axons and oligodendrocytes during oxygen glucose deprivation. Soc Neurosci. Abstr. 26:2065, 2000.

38. Baltan Tekkök, S., Faddis BT. and Goldberg MP. Overactivation of AMPA/kainate receptors causes axonal injury in mouse brain slices. Soc Neurosci. Abstr. 27:2065, 2001.

39. Inoue I, Baltan Tekkök, S., Yang P. and Goldberg MP. Delayed axonal injury after glucose deprivation is attenuated by AMPA receptor blockade. 27th International Stroke Meeting, Feb 7-9, 2002, San Antonio.

40. Baltan Tekkök, S, Brown AM., and Ransom BT. Persistence of axonal function during anoxia in mouse optic nerve. Glia, Supp 1, May S66, 2002.

41. Baltan Tekkök, S., Ye ZC., Brown AM. and Ransom BR. Glutamate and aspartate are released from mouse optic nerve during oxygen glucose deprivation. Glia, Supp 1, May S66, 2002.

42. Baltan Tekkök, S, Brown AM., and Ransom BT. Why CNS White matter is relatively resistant to anoxia. Soc Neurosci. Abstr. Orlando, 2002.

43. Baltan Tekkok, S., Ye ZC., Brown AM. and Ransom BR. Glutamate and aspartate are released from mouse optic nerve during oxygen glucose deprivation. Soc Neurosci. Abstr. Orlando, 2002

44. Angus M. Brown, Ruth E. Westenbroek1, Baltan Tekkök S and Ransom BR. Functional Insulin receptors are selectively expressed on CNS astrocytes. Soc Neurosci. Abstr. Orlando, 2002

45. Brown AM, Westenbroek RE, Baltan Tekkök S and Ransom BR. Glycogen regulation and its role in supporting hippocampal synaptic plasticity. British Neuroscience Meeting, London, 2003.

46. Hamner AM, Baltan Tekkök S, and Ransom BR. The effects of aging on ischemic white matter injury. Mary Gates Undergraduate Research Symposium, Seattle, WA 2003.

47. Baltan Tekkök S and Ransom BR. Activation of AMPA or kainate receptors is sufficient to cause white matter injury. Glia 43:20, 2003.

48. Baltan Tekkök S, Brown A and Ransom BR. On the role of D-lactate as a competitive inhibitor for intercellular L-lactate transport into mouse optic nerve, a central white matter tract. J Physiol (London), 551P: C66, 2003.

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March 2016 49. Tuncer M, Baltan Tekkök, S and Ransom NR. Melatonin protects white matter ischemic injury. Soc for Neurosci, New Orleans, 2003

50. Baltan Tekkök S, Brown A and Ransom BR. D-Lactate inhibits the transfer of L-Lactate from astrocytes to axons during aglycemia in white matter. Soc for Neurosci, New Orleans, 2003

51. Hamner AM, Baltan Tekkök S, and Ransom BR. Ageing increases the vulnerability of white matter to ischemia. Soc for Neurosci, New Orleans, 2003

52. Ransom BR, Tekkök SB, Brown A. Astrocytic glycogen and energy metabolism in CNS axons. Glia, Suppl 2:4, 2003.

53. Baltan Tekkök S and Bruce R ransom. Regional differences in response to anoxia in CNS function and survival. Soc for Neurosci Meeting, SanDiego CA, 2004.

54. Baltan Tekkök S and Ransom BR. Regional differences in excitotoxic white matter injury. Euroglia2005, Amsterdam, The Netherlands, 2005.

55. Ransom BR and Baltan Tekkök S. Receptor pharmacology of excitotoxic injury in mouse optic nerve. Soc for Neurosci, Washington DC, 2005.

56. Baltan Tekkök S, Besancon FE and Ransom BR. Older adult animals of mechanisms of ischemic white matter injury. Soc for Neurosci, Washington DC, 2005.

57. Willis D, Hamner M, Baltan Tekkök S and Ransom BR. Identifying glial cell population susceptible to ischemic injury in adult mammalian white matter. Mary Gates Undergraduate Research Symposium, Seattle, WA, 2005.

58. Baltan Tekkök S, Besancon FE and Ransom BR. Mechanism of increased vulnerability of white matter to ischemic injury in older animals. American Soc for Neurochem, Portland, Oregon, 2006.

59. Lee LA, Baltan Tekkok S, Deem S, Moulding J, and Arthur M Lam. A novel model of in vivo pig posterior optic nerve ischemia. ASA 2006 Annual Meeting, 2006.

60. Ransom BR and Baltan Tekkök S. Do NMDA receptors participate in ischemic white matter injury in young adults? Soc for Neurosci, Atlanta, GA, 2006.

61. Baltan Tekkök S, Tuncer M and Ransom BR. Free radicals and oxidative stress contribute to ischemia-induced white matter injury. Soc for Neurosci, Atlanta, GA, 2006.

62. Ransom BR and Baltan Tekkok S. Receptor pharmacology of excitotoxic injury in CNS white matter. EPVA Annual Meeting, Las Vegas September 2006.

63. Baltan S. Energy metabolism and axonal susceptibility to anoxia. IBRO 2007, Function of myelianted axons and glial-axonal signaling in the CNS: Basic aspects and clinical implications Symposium 4, Melbourne Australia, July 2007.

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March 2016 64. Baltan S. Mechanisms of ischemic injury in aging white matter. EuroGlia 2007, Neurotransmitter signaling to oligodendrocytes and neurological disease symposium 14, London, UK, September 2007.

65. Baltan S, Mbow, B and Ransom BR. NMDA type glutamate receptors and ischemic white matter injury during early development Soc for Neurosci, San Diego, CA, 2007.

66. Baltan S, del Zoppo G, Becker K, Nedergaard M, Lo E, Ransom BR. Activase protects white matter against ischemic injury. International Stroke Meeting, New Orleans, 2008.

67. Baltan S, del Zoppo G, Becker K, Nedergaard M, Lo E, Ransom BR. Activase protects white matter against ischemic injury. Society for Neuroscience, Washington DC, 2008.

68. Ransom BR and Baltan S. Ischemic injury of oligodendrocytes in CNS white matter. The 3rh ISN Special Neurochemistry Conference, July 2008, Beijing, China, 2008.

69. Inman DM, Baltan S, Calkins, DJ, Horner, PJ. High IOP decreases compound action potential amplitude and leads to preferential loss of physiologically identified small caliber axons in DBA/2 optic nerve. ARVO, Ft Lauderdale, FL, May 2009.

70. Saab A, Baltan S, Moebius W, Goetze B, Lowel S, Goebbels S, Perez-Samartin A, Perez-Cerda F, Matute C, Nave KA, Kirchhoff F. Mouse optic nerves lacking oligodendrocglial NMDA receptors are more vulnerable to ischemic insults. Gordon Research Conference, Ventura, CA 2009.

71. Baltan S, Inman D, Danilov C, Morrison R, Calkins DJ, Horner P. Reduced ATP levels dispose axons to dysfunction in a model of glaucomatous degeneration. Society for Neuroscience, Chicago, October 2009.

72. Baltan S and Ransom BR. Structural targets of anoxia in mammalian white matter. Euroglia Paris, September 2009.

73. Ransom, BR and Baltan S. Structural targets of anoxia in mammalian white matter. Society for Neuroscience, Chicago, October 2009.

74. Baltan S, Murphy SP, Danilov CA, Bachleda A Morrison RS. Class I histone deacetylase (HDAC) inhibitors preserve glial cell function and viability to protect white matter from ischemic injury. Society for Neuroscience, San Diego, November 2010.

75. Murphy S, Baltan S, Danilov CA, Bachleda A and Morrison RS. Class 1 histone deacetylases (HDACs) are selectively expressed in axonal and glial cell compartments. Society for Neuroscience, San Diego, November 2010.

76. Baltan S, Bachleda A, Morrison RS and Murphy SP. Expression of histone deacetylases in cellular compartments of the mouse brain and the effects of ischemia. Society for Neuroscience, Washington DC, November 2011

77. Baltan S., Dutta R., Brunet S., Chomyk A., Grahame K., Trapp B. Demyelination affects memory function. Society for Neuroscience, New Orleans, LO, October 2012.

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March 2016 78. Provencio, J., Brunet S., Baltan, S. Delayed Cerebral Injury Associated With Vasospasm (DCI) After Subarachnoid Hemorrhage (SAH) is Associated with Synaptic Dysfunction in the Hippocampus. Oral Presentation at the 10 th Annual Neurocritical Care Society Meeting, Denver Colorado, Oct4-7, 2012.

79. Runkle A, Brunet S, Baltan S. L-NAME preserves axon function against ischemia in young adult mammalian white matter. CCLCM –CWRU Research Day, Cleveland OH, September 14, 2013.

80. Zaleski J, Bachleda A, Runkle A, Brunet S, Baltan S. Age-dependent activity of nitric oxide synthase during ischemic white matter injury. July 3-6, 2013 EuroGlia, Berlin Germany.

81. Zaleski J, Bachleda A, Runkle A, Brunet S, Baltan S. Nitric oxide synthase activity contributes to ischemic axon injury. J Caroll University, Research Day, Cleveland, OH June 2013.

82. Provencio, JJ., Seerapu, S., Brunet S., Swank, V., Baltan, S. Behavioral deficits in delayed deterioration associated with vasospasm are mediated by synaptic NMDA receptors in the hippocampus. 12th International Conference on Neurovascular events after subarachnoid hemorrhage. Lucerne, Switzerland, July 10-12, 2013.

83. Baltan S, Dutta R, Brunet S, Chomyk A, Kidd G, Trapp BD. Demyelination impairs synaptic transmission and plasticity in a mouse model of multiple sclerosis. ISN Myelin Satellite Meeting, April 16-20, Cancun Mexico, 2013.

84. Teknipp R, Bhatta S, Brunet S, Baltan S. Inhibitors of deacetylase preserve aging axons after an ischemic attack. J Caroll University, Research Day, Cleveland, OH June 2013.

85. Bastian C, Zaleski J, Bachleda A, Runkle A, Brunet S, Baltan S. Age-dependent axonal recovery from white matter ischemic injury by inhibition of nitric oxide synthase enzyme. The Cleveland Clinic Foundation, Neurological Institute Research Day, LRI, Cleveland, OH, May 2013.

86. Bhatta S, Bastian C, Brunet S, Lamb B, Baltan S. Impaired synaptic transmission and plasticity in a mouse model of taupathy. The Cleveland Clinic Foundation, Neurological Institute Research Day, LRI, Cleveland, OH, May 2013.

Sabina Bhatta – Poster and scientific winner of the Neurological Institute Research Day May 2013, Cleveland Clinic, Cleveland OH.

87. Baltan S, Bhatta S, Bastian C, Brunet S, Lamb BT. Impaired synaptic plasticity precedes tau aggregation in hTau mouse model of Alzheimer’s disease. Alzheimer’s Association International Conference, Copenhagen, Denmark, July 12-17, 2014.

88. C. Bastian, J. Zaleski, A. Bachleda, S. Brunet, S. Baltan. Age- and isoform specific NOS inhibition protects axon function against ischemia by scavenging free radicals and preserving mitochondrial dynamics. LRI Research Day 2014.

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March 2016 89. C. Bastian, J. Zaleski, A. Bachleda, S. Brunet, S. Baltan. Age- and isoform specific NOS inhibition protects axon function against ischemia by scavenging free radicals and preserving mitochondrial dynamics. NIRD 2014.

90. Stahon K, Bastian C, Kidd G, Brunet S, Baltan S. Age-dependent modifications of axons, mitochondrial dynamics, and calcium homeostasis underlie the vulnerability of aging white matter to ischemia. LRI Retreat 2014.

91. Stahon K, Bastian C, Kidd G, Brunet S, Baltan S. Age-dependent modifications of axons, mitochondrial dynamics, and calcium homeostasis underlie the vulnerability of aging white matter to ischemia. NIRD 2014. 92. Brunet S, Baltan S. Age-dependent modifications of axons, mitochondrial dynamics, and calcium homeostasis underlie the vulnerability of aging white matter to ischemia. J Caroll University, Research Day, Cleveland, OH April 2014.

93. Stahon K, Bastian C, Kidd G, Brunet S, Baltan S. Age-dependent reorganization of axonal structures, myelin, mitochondrial dynamics and calcium homeostasis underlie the vulnerability of aging white matter to ischemia. World Stroke Congress, Istanbul, October 2014.

94. C. Bastian, J. Zaleski, A. Bachleda, S. Brunet, S. Baltan. Isoform-specific NOS inhibition preserves axon function against ischemia in an age-dependent manner by enhancing free radical scavenging and preserving mitochondrial structure and function. Society for Neuroscience, Washington DC, November 2014.

95. Baltan S. Stahon K, Bastian C, Kidd G, Brunet S. Age-dependent alterations in axon-myelin interactions, mitochondrial dynamics and Ca2+ homeostasis underlie the increased vulnerability of aging axons to ischemia. Society for Neuroscience, Washington DC, November 2014.

96. Rosenberg, PA, Landefeld, C., Bastian C., Makinodan M., Corfas G., Baltan S. Oligodendrocytes support axon function via glutamate signaling thorugh glutamate transporter (GLT-1) in a gender and age-specific manner. Society for Neuroscience, Washington DC, November 2014.

97. C. Bastian, J. Zaleski, A. Bachleda, S. Brunet, S. Baltan. Age and iso-form specific NOS inhibitionprotects axon function against ischemia by scavenging free radicals and preserving mitochondria. May 22, 2014, Neurological Institute Research Day.

Chintha Bastian: Post-doctoral Neurosciences poster and scientific winner of the Neurological Institute Research Day May 2014, Cleveland Clinic, Cleveland OH.

98. Stahon K, Bastian C, Kidd G, Brunet S, Baltan S. Age-dependent modifications of axons, mitochondrial dynamics and calcium homeostasis underlie the vulnerability of aging white matter to ischemia. May 22, 2014, Neurological Institute Research Day 99. Baltan S, Stahon K, Bastian C, Kidd G, Brunet S. Mitochondrial dysfunction and aggravated oxidative stress mediate increased vulnerability of aging white matter to ischemia. July 14-18, EuroGlia 2015 Bilboa, Spain.

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March 2016

NATIONAL AND INTERNATIONAL INVITED SEMINARS/SYMPOSIA/GRANDROUNDS:

1. Glucose-dependence of synaptic plasticity in hippocampal slices from middle-aged rats. Royal Victoria Hospital Anesthesia Research Department Seminar Series, Montreal, Canada, May 1998.

2. Glucose dependence of neuronal activity. The Toronto Hospital, Western Division Seminar Series, Toronto, Canada, October 1998.

3. Excitotoxic white matter injury. Harborview Medical Center, Research and Training Building Annual Seminars, Seattle, May 2001.

4. Excitotoxic white matter injury. Young Investigator Seminar Astrocyte Function in Health and Disease, NIH Workshop, Rockville, Maryland. September 2002.

5. White matter matters. University of Washington, Department of Neurology Grand Rounds, Seattle, May 2002.

6. Role of astrocytic glycogen in neuro-glial metabolic coupling. Harborview Medical Center, Endocrinology and Metabolism Department, Seattle, Dec 2003.

7. Anoxia on the central nervous system function; a regional study. Harborview Medical Center, Research and Training Building Annual Seminars, Seattle, May 2004.

8. Regional differences in excitotoxic white matter injury. EuroGlia2005, Amsterdam, The Netherlands, May 2005.

9. Regional and age specific mechanisms of stroke in white matter. University of Washington, Department of Neurology Grand Rounds, Seattle, Oct. 2005.

10. Excitotoxic mechanisms of stroke in white matter. VAPSHCS GRECC, Seattle, Nov 2005.

11. Regional and age specific mechanisms of stroke in white matter. Harborview Medical Center, Department of Neurosurgery, Seattle, June 2006.

12. What matters is white matter. University of Washington, Stroke Club, Seattle, November 2006.

13. Recent insights into the mechanisms of myelinated nerve injury. University of Washington, Oral Biology 575 Winter Quarter, Seattle, Feb 2007.

14. Physiology of neural response to injury. BMES ERC Cell Biology Symposium, USC, Center of Excellence, LA, CA, Feb 2007.

15. Does aging increase vulnerability of white matter to stroke. Harborview Medical Center, Department of Neurology Becker Lab Meeting, Seattle, March 2007.

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March 2016 16. In vitro effects of tissue plasminogen activator on white matter function and injury. University of Washington, Stroke Club, Seattle, May, 2007.

17. Preventing neurological dysfunction after stroke “protecting white matter”. Science Innovation Synergy (SIS), Cognitive dysfunction session, Seattle, The Westin Hotel, August 3, 2007.

18. Mechanisms of ischemic injury in aging white matter. EuroGlia 2007. Neurotransmitter signaling to oligodendrocytes and neurological disease symposium 14, London, UK, September 2007.

19. Quest for surviving stroke”Protecting the White Matter”. Burke Institute, Cornell University, Weil Medical School, White Plains, NY, Dec 2007.

20. Quest for surviving stroke”Protecting the White Matter”. Neurogenetics Department, Max Planck Institute, Goettingen, Germany Jan 2008.

21. Quest for surviving stroke ”Protecting the White Matter”. Department of Anesthesiology, University of Maryland, Baltimore, MD, February 2008.

22. Quest for survival; Aging White Matter and Stroke. University of Washington, Department of Neurology Grand Rounds, Seattle, April 3, 2008.

23. Developmental and age-specific role of NMDA receptors in ischemic white matter injury. Neurogenetics Department, Max Planck Institute, Goettingen, Germany May 2008.

24. Ischemic white matter injury: an age-dependent process. Neurology and Neuroscience Departments, The Ohio State University, Feb 11 2009.

25. Excitotoxic oligodendrocyte injury in white matter. Neuroscience Graduate Studies Program, Excitotoxicity Course, The Ohio State University, Feb 11 2009.

26. Excitotoxic oligodendrocyte injury during ischemic white matter injury. Gordon Research Conference, Ventura, CA, March 17 2009.

27. Ischemic white matter injury to white matter: An age-dependent process. Ottawa University, Center for Stroke Recovery, June 1, 2009

28. Oligodendrocyte excitotoxicity dictates region and age specific mechanisms of stroke in white matter. Grand Rounds, Neurology Department, University of Washington, Seattle, June 4 2009.

29. Oligodendrocyte injury during white matter ischemia. Department of Neurobiology and Center for Glial Biology, University of Alabama, Birmingham, January 7 2010.

30. Role of oligodendrocytes on axon dysfunction during ischemic injury. Gordon Research Meeting (Myelin), Ventura, CA February 17 2010.

31. The impact of oligodendrocyte excitotoxicity axon dysfunction during ischemic injury. 7/18/2011 of 29


March 2016 Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, April 22 2010.

32. Glaucoma is a disease of aging optic nerve. University of Washington, Department of Neurology Grand Rounds, Seattle, November 3, 2010.

33. Excitotoxicity and mitochondrial dysfunction lead to axonal degeneration. Keystone Meeting, Taos, NM, Feb 19 2011.

34. The role of oligodendrocytes in preserving axon function. EuroGlia, Prague, Czech Republic, September 2011.

35. Excitotoxicity and mitochondrial dysfunction underlie age-dependent ischemic white matter injury, Antalya, September 2011.

36. Excitotoxicity and mitochondrial dysfunction underlie age-dependent ischemic white matter injury, Baltimore, MD, March 2012

37. Age-dependent mechanisms of ischemic white matter injury. Data on the table, Neurosciences, LRI, CCF, March 2012

38. Preserving mitochondrial dynamics protects white matter against ischemic injury, UMU-SU Integrated Neuroscience Graduate Program, Syracuse, NY, May 2012.

39. Age-dependent mechanisms of white matter injury after stroke. Lerner Research Institute, Annual Retreat, Cleveland OH, September 8 2013.

40. Age-dependent increase in ischemic injury and mechanisms of ischemic white matter injury as a function of age. Hacettepe University, Neurological Sciences, Ankara, Turkey, 2012.

41. (Turkish Title) Iskemik inme atak riskinin yasla artma nedenleri ve yasla degisen beyaz cevher iskemik hasar mekanizmalari (Age-dependent increase in ischemic injury and mechanisms of ischemic white matter injury as a function of age). 48th National Turkish Neurological Meeting, November 16-22, Antalya, Turkey, 2012.

42. Vulnerability of aging white matter to ischemia. International Stroke Meeting, Feb 6-8 2013, Honolulu, HI.

43. Epigenetics of white matter stroke. Neurodegenerative Disease Research group.Data on the Table. Jan 13, 2014.

44. Quest for surviving stroke; “Protecting the white matter”. LRI, Mid-term evaluation, CCF, June 25, 2014 Cleveland, USA.

45. Novel therapeutic approaches for stroke treatment. LRI, Early promotion seminar, CCF, Dec 5, 2014, Cleveland, USA.

46. Epigenetics of white matter stroke. Department of Neurology, University of Pittsburgh, Pennsylvania, USA. Dec 10-11, 2014

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March 2016

47. Epigenetics of white matter stroke. Case Western Reserve University Department of Neurosciences, March, 2015.

48. Mitochondrial dynamics in white matter stroke. 46 th Meeting of American Society for Neurochemistry, Atlanta, GE, USA. March 14-18, 2015.

49. Ultrastructural morphology of white matter axons as a function of age and ischemia. XXIV th International Symposium on Morphological Sciences (ISMS), Istanbul, Turkey, September 2-6, 2015.

50. Mitochondrial dynamics in white matter stroke. 12th International Conference on Brain Energy Metabolism. ICBEM, Hong Kong, May 2016.

51. Epigenetic regulation of white matter stroke. XIV. Neurological Institute Dyas, Hacettepe University, Ankara Turkey. April 11, 2016

52. Anatomy of white matter ischemia. Anatomy department of Hacettepe university, Ankara, Turkey, April 13, 2016.

53. Epigenetics of white matter stroke. Indianapolis University, STARK Center, USA, April 2016.

54. Epigenetics and white matter. National Institutes of Health, MD, USA, June 2016.

55. Epigenetic regulation of white matter stroke. University of Alabama at Brimingham, AL, USA, September 2016.

56. Vascular aspects as a cause or contributor to neurodegenerative diseases. Cold Spring Harbor Meeting on Neurodegenerative Diseases, NY, USA, November, 2016.

57. Pathophysiology of White Matter Stroke. Conditioning Strategies for Neurological Disorders, Suzhou, China. November 2016.

58. Ischemic Stroke and white matter. February 2017, Loma Linda University, CA, October 2016, USA

Favorite Leisure Time Activities

Ballroom dancing at WHYM Dance Studio, – Solon, Chagrin Falls, OH 2014. Dancer at Pacific Northwest Ballet, training under Christophe Maraval (Principle

Dancer, 2004-2007), Anton Pankevich (Corps de Ballet, 2007-2009), Michele Curtis and Bruce Wells (Intermediate/advanced class, 2009-2011).

Hiking, traveling and cooking traditional Turkish and French cuisines.

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