Curriculum VitaeAi-Guo Wu

Room A514, No 519 Zhuangshi Road, Ningbo, Zhejiang, 315201, China Telephone: (0086) 574-8668-5039 (Office)E-mail: aiguo@ nimte.ac.cn or aiguowu2008@yahoo.com

Education:

Ph.D. Analytical Chemistry State Key Laboratory of Electroanalytical Chemistry

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jinlin Province, China Defended time: December 2003, Certificated time: March 2004

Dissertation: DNA, Nanoparticles and their interactions investigated by scanning probe microcopy (SPM)Thesis Advisor: Prof./Dr. Erkang Wang and Prof. /Dr. Zhuang Li

B. S. Department of ChemistryNanchang University, Nanchang, China, July 1998

Honor thesis: Simultaneous determination of halide and thiocyanate ions by potentiometric precipitation titration and multivariate calibration

Thesis Advisor: Prof. Yongnian Ni

Professional Experience:

1) 6/2009-Present Professor Division of Functional Materials and NanodevicesNingbo Institute of Material Technology & Engineering (NIMTE), Chinese Academy of Sciences (CAS)

Research Interests: (1) Biomedical Imaging based on various nanomaterials; (2) Applications of Nanomaterials for Environmental Sciences; (3) Preparation of Nanostructures based on biomacromolecules

2) 5/2006 – 6/2009: Research Associate in Medical SciencesDepartment of Radiation Oncology &

Department of Radiology Feinberg School of Medicine Northwestern University, USA

Supervisor: Prof./Dr. Gayle E. Woloschak

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Research Interests: (1) Biomedical Imaging based on various nanomaterials (MRI and CT); (2) Study of DNA-TiO2 based nanocrystals and its applications in medical detection and imaging; (3) Preparation of metal oxide nanocrystals, especially various (super)paramagnetic nanocrystals in air around room temperature, different noble metal nanoparticles, and multiple modal nanocrystals (such as core-shell and core-corona-shell nanocrystals)

2) 7/2005- 4/2006 Postdoctoral Scholar/Research Associate in Chemistry Chemistry and Chemical Engineering Division

California Institute of Technology, USASupervisor: Prof. /Dr. Ahmed H. Zewail(Nobel Prize winner for Chemistry in 1999)

Research Interests: (1) Ultrafast dynamics of DNA hairpins, (2) Ultrafast T-jump studies of the interaction of Metal-Ligand

3) 2/2004-7/2005 PostdoctorDepartment of ChemistryUniversity of Marburg, GermanySupervisor: Prof./Dr. Nobert A. Hampp

Research Interests: (1) Soft matters decoration of purple membrane, (2) SPM in liquid (Nanoscope IV system with picoforce extension), (3) High resolution images for membrane proteins, (4) Soft materials assembly of carbon nanotube (Scanning Conductive Microscopy), (5) Manipulating and imaging of various structures of purple membrane sheets

4) 9/1998 –12/2003 Research Assistant State Key Laboratory of Electroanalytical Chemistry

Changchun Institute of Applied ChemistryChinese Academy of Sciences, Changchun, China

Research Interests: SPM study of the interaction of DNA and nanoparticles, nanodevices (for example, nanowire) and various nanostructures using DNA as the fabricated templates. The Principal Projects were: (1) Preparing DNA Mapping by SPM, (2) Single Nanocrystal Electrochemistry, (3) Preparing Controllable Nanowire.

Expertise:

Medicine Contrast agents, Computed tomography (CT), Magnetic resonance imaging (MRI)

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Radiology Gel electrophoresis with radiation label, fluorescent gel electrophoresis, in-situ hybridization of nanocomposites with radiation label, X-ray fluorescence microscopy

Chemistry Ultraviolet visible spectrometer (Uv-Vis), Fourier transfer infrared spectrometer (FTIR), inductive coupled plasma-mass spectrometer (ICP-MS), Raman spectrometer, fluorescence spectrometer, organic chemistry synthesis, inorganic chemistry synthesis, the partial least squares (PLS) for chemometrics

Nanotechnology Preparing various nanocrystals, preparing nanocomposites based on nuceic acids and nanocrystals, fabricating 2D/3D nanostructures, surface functionalization of nanocrystals, nanomanipulation based on scanning probe microscopy (SPM)

Biophysics Advanced photon source (Argonne National Lab.), atomic force microscopy, scanning tunneling microscopy, in situ scanning probe microscopy, scanning conductive microscopy, transmission electron microscopy (TEM), optical microscopy, ultrafast laser

Molecular Biology PCR, cell transfection, cell viability

Teaching Experience:

1. Summer 2008: Co-supervisor Department of Radiation Oncology & Department of Radiology Feinberg School of Medicine, Northwestern University Assisted and mentored rotation of undergraduate students in biology

2. November 2007: Guest Lecturer Loyola University Chicago Lessons of Natural Sciences for Culture and Arts Students

3. March-May 2007: Co-supervisor Department of Radiation Oncology & Department of Radiology Feinberg School of Medicine, Northwestern University

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Assisted and mentored rotation of postgraduate students in biology

4. Summer 2006: Co-supervisor Department of Radiation Oncology & Department of Radiology Feinberg School of Medicine, Northwestern University

Assisted and mentored minority undergraduate summer program in biology

5. 1998- 2003: Co-supervisor State Key Laboratory of Electroanalytical Chemistry

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China

Assisted and mentored undergraduate students on their bachelor thesis projects in chemistry and biophysics

Honors and Awards:

1. YinGang Peng Outstanding Postgraduate Student Award, Chinese Academy of Sciences, China, 2001

2. Outstanding Postgraduate Student Award, Changchun Institute of Applied Chemistry, Changchun, Jilin, China, 2001

3. Honor thesis, Nanchang University, Nanchang, Jiangxi, China, and July 1998

4. A Silver Prize of Mathematics Modeling Contest for Chinese University Student, JiangXi Contest Zone, Nanchang, Jiangxi, China, 1997

5. Outstanding Undergraduate Student Awards in Nanchang University, Nanchang, Jiangxi, China, 1995-1998

Publications: Cited >500 times, H-index=11

1) A Full List of Refereed Journals (35 Total)

1. Aiguo Wu , Tatjana Paunesku, Eric M. B. Brown, Angela Babbo, Cecille Cruz, Mohamed Aslam, Vinayak Dravid and Gayle E Woloschak, Titanium Dioxide Nanoparticles Assembled by DNA Molecules Hybridization and Loading of DNA Interacting Proteins, NANO, (2008), 3(1), 27-36. (SCI) Cited Times: 1 (SCI)

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2. Aiguo Wu , Zhihong Jia, Andreas Schaper, Frank Noll, and Norbert A. Hampp, Simultaneous Removal of Thiolated Membrane Proteins Resulting in Nanostructured Lipid Layers, Langmuir, (2006), 22(12), 5213-5216. Cited Times: 1 (SCI)

3. Aiguo Wu , Wenlong Cheng, Zhuang Li, Junguang Jiang, and Erkang Wang Electrostatic-assembly metallized nanoparticles network by DNA template, Talanta, (2006), 68, 693-699. Cited Times: 19. (SCI)

4. Aiguo Wu , Zhuang Li, Hualan Zhou, and Erkang Wang, Nanoscale Structures of Circle-MgCl2 Constructed by Plasmid DNA Templates, Superlattices and Microstructures, (2005), 37(3), 151-161. Cited Times: 3. (SCI/EI)

5. Aiguo Wu , Lihua Yu, Zhuang Li, Huanming Yang, and Erkang Wang, Atomic Force Microscope Investigation of Large-Circle DNA Molecules, Analytical Biochemistry, (2004), 315(2), 293-300. Cited Times: 7. (SCI)

6. Aiguo Wu , Zhuang Li, and Erkang Wang, DNA Network Structures on Various Solid Substrates Investigated by Atomic Force Microscopy, Analytical Sciences, (2004), Vol. 20(7), 1083-1086. Cited Times: 4. (SCI)

7. Aiguo Wu , Gang Wei, Zhuang Li, and Erkang Wang, Biological Samples Investigated by Atomic Force Microscopy (A Review in Chinese), Chinese Journal of Analytical Chemistry, (2004), 32(11), 1538-1543. (SCI)

8. Aiguo Wu , Zhuang Li, Lihua Yu, Hongda Wang, and Erkang Wang, A Relocated Technique of Atomic Force Microscopy (AFM) Samples and its Application in Molecular Biology, Ultramicroscopy, (2002), Vol.92, 3-4, 201-207. Cited Times: 8. (SCI/EI)

9. Aiguo Wu , Zhuang Li, Hualan Zhou, Jianping Zheng, and Erkang Wang, Construction and Control of Plasmid DNA Network, The Analyst, (2002), 127(5), 585-587. Cited Times: 11. (SCI)

10. Aiguo Wu , Zhuang Li, Lihua Yu, Hongda Wang, and Erkang Wang, Plasmid DNA Network on a Mica Substrate Investigated by Atomic Force Microscopy, Analytical Sciences, (2001), Vol.17, 583-584. Cited Times: 15. (SCI)

11. Hairong Ma, Chaozhi Wan, Aiguo Wu, and Ahmed H. Zewail, DNA folding and melting observed in real time redefine the energy landscape, Proceedings of the National Academy of Sciences of the United States of America, (2007), Vol. 104, 712-716. Cited Times: 20. (SCI/EI)

12. Lihua Yu, Aiguo W u , Hongda Wang, and Zhuang Li, Deoxyribonucleic Acid

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Sample Preparation in Scanning Probe Microscopy, Chinese Journal of Analytical Chemistry (in Chinese), (2001), Vol. 29, 1470-1477. (SCI)

13. Eric M.B. Brown, Tatjana Paunesku, AiGuo Wu, K. Ted Thurn, Benjamin Haley, Jimmy Clark, Taisa Priester, Gayle E. Woloschak, Methods for assessing DNA hybridization of peptide nucleic acid–titanium dioxide nanoconjugates. Analytical Biochemistry, (2008), 383(2), 226-235. (SCI)

14. Tatjana Paunesku, Tianyi Ke, Rohan Dharmakumar, Nicole Mascheri, Aiguo Wu, Barry Lai, Stefan Vogt, Jörg Maser, Kenneth Thurn, Barbara Szolc-Kowalska, Andrew Larson, Raymond C. Bergan, Reed Omary, Debiao Li, Zheng-Rong Lu, Gayle E. Woloschak, Gadolinium-conjugated TiO2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images. Nanomedicine: Nanotechnology, Biology and Medicine, (2008), 4(3), 201-207. (SCI) Cited Times: 5. (SCI)

15. Jianping Zheng, Zhuang Li, Aiguo Wu, and Hualan Zhou, AFM Studies of DNA Structures on Mica in the Presence of Alkaline Earth Metal Ions, Biophysical Chemistry, (2003), 104, 37-43. Cited Times: 12. (SCI)

16. Jianping Zheng, Zhuang Li, Aiguo Wu, Hualan Zhou, Hanying Bai, and Yonghai Song, The Structural Transition of DNA-Tris(1,10-phenathroline) Cobalt(III) Complexes in Ethanol-Water Solution, Biochemical and Biophysical Research Communications, (2002), 299, 910-915. Cited Times: 11. (SCI)

17. Lihua Yu, Zhuang Li, Aiguo W u , Hongda Wang, Quanlin Suo, Xiaohui Bi, and Baiqu Huang, The AFM Characterization of Ni(Phen)32+ Fixing Effects on DNA, Chemical Journal of Chinese Universities-Chinese (in Chinese), (2002), Vol.23(1), 46-48. Cited Times: 2. (SCI)

18. Jianbo Jia, Bingquan Wang, Aiguo Wu, Guangjin Cheng, Zhuang Li, and Shaojun Dong, A Method to Construct a Third-Generation Horseradish Peroxidase Biosensor: Self-Assembling Gold Nanoparticles to Three-Dimensional Sol-Gel Network, Analytical Chemistry (2002), Vol. 74, 2217-2223. Cited Times: 233. (SCI)

19. Yan Shen, Jianyun Liu, Aiguo Wu, Junguang Jiang, Lihua Bi, Baifeng Liu, Zhuang Li, and Shaojun Dong, Preparation of Pt Nanoparticles Assembled in Multilayer Films, Chemistry Letters, (2002), No.5, 550-551. Cited Times: 4. (SCI/EI)

20. Li Wang, Yonghai Song, Aiguo Wu, Zhuang Li, Bailin Zhang, and Erkang Wang, Study of Methanol Adsorption on Mica, Graphite and ITO Glass by Using

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Tapping Mode Atomic Force Microscopy, Applied Surface Science, (2002), 199(1-4), 67-73. Cited Times: 13. (SCI/EI)

21. Lin Xu, Hongyu Zhang, Enbo Wang, Aiguo Wu, and Zhuang Li, Preparation, Characterization and Luminescence Properties of Ultrathin Films Containing Polyoxomealates, Materials Letters, (2002), 54(5-6), 452-457. Cited Times: 10. (SCI/EI)

22. Lin Xu, Hongyu Zhang, Enbo Wang, Aiguo Wu, and Zhang Li, Preparation and Characterization of Photoluminescent Ultrathin Films Based on Polyoxometalates, Materials Chemistry and Physics, (2003), Vol.77(2), 484-488. Cited Times: 14. (SCI/EI)

23. Chunhua Zhang, Zhenghua Yang, Mengxian Ding, Aiguo Wu, and Zhuang Li, The Surface Property and Morphology of the Polyimides Having Fluorinated Main Chains for Liquid Crystal Alignment, Chinese Journal of Applied Chemistry (In Chinese), (2001), Vol. 18(7), 544-547.

24. Yongnian Ni, and Aiguo W u , Simultaneous Determination of Halide and Thiocyanate Ions by Potentiometric Precipitation Titration and Multivariate Calibration, Analytica Chimica Acta, (1999), 390, 117-123. Cited Times: 21. (SCI)

25. Min Jiang, Enbo Wang, Zhenhui Kang, Suoyuan Lian, Aiguo Wu, and Zhuang Li, In Situ Controllable Synthesis of Polyoxometalate Nanoparticles in Polyelectrolyte Multilayers, Journal of Materials Chemistry, (2003), 13 (4), 647-649. Cited Times: 11. (SCI)

26. Hongyu Zhang, Lin Xu, Enbo Wang, Min Jiang, Aiguo Wu, and Zhuang Li, Photochromic behavior and luminescent properties of novel hybrid organic-inorganic film doped with Preyssler's heteropoly acid H12[EuP5W30O110] and polyvinylpyrrolidone, Materials Letters (2003), 57(8), 1417-1422. Cited Times: 26. (SCI/EI)

27. Yan Shen, Jianyun Liu, Aiguo Wu, Junguang Jiang, Lihua Bi, Baifeng Liu, Zhuang Li, and Shaojun Dong, Preparation of multilayer films containing Pt nanoparticles on a glassy carbon electrode and application as an electrocatalyst for dioxygen reduction, Langmuir (2003), 19, 5397-5401. Cited Times: 29. (SCI)

28. Hualan Zhou, Zhuang Li, Aiguo Wu, Jianping Zheng, Jian Zhang, and Shifa Wu, The influence of tip performance on scanning probe lithography, Applied Surface Science, (2004), 221, 402-407. (SCI/EI)

29. Jinzhong Wang, Guotong Du, Yan Ma, Baijun Zhao, Xiaotian Yang, Yuantao

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Zhang, Dali Liu, Wancheng Li, Hongjun Yang, Shuren Yang, Aiguo Wu, and Zhuang Li, Study on NH3 doping in ZnO film grown on R-plane of sapphire substrate., Faguang Xuebao (Chinese Journal of Luminescence), (2003), 24(4), 335-338 (In Chinese). Cited Times: 1.

30. Min Jiang, Hong Zhang, Enbo Wang, Zhenhui Kang, Suoyuan Lian, Lin Xu, Aiguo Wu, and Zhuang Li, Assembly and characterization of rare-earth-containing polyoxometalate [Eu(P2Mo17O61)2]17- and poly(allylamine hydrochloride) multilayer films, Chemical Research in Chinese Universities, (2004), 20(1), 15-19. (SCI)

31. Hualan Zhou, Zhuang Li, Aiguo Wu, Gang Wei and Zhiguo Liu, Direct patterning of rhodamine 6G molecules on mica by dip-pen nanolithography, Applied Surface Science, (2004), 236(1-4 ),18-24. Cited Times: 5. (SCI/EI)

32. Jianyun Liu, Yongdong Jin, Aiguo Wu, Zhuang Li, and Shaojun Dong, Fabrication and Characterization of DNA/QPVP-Os Redox-Active Multilayer Film, Electroanalysis, (2004), 16(23), 1931-1937. Cited Times: 3. (SCI)

33. Lin Xu, Jishuang Zhang, Weixiao Cao, AiguoWu, and Zhuang Li, Stable multilayer films based on photoinduced interaction between polyoxometalates and diazo resin, Materials Letters, (2004), 58(27-28), 3441-3446. Cited Times: 3. (SCI/EI)

34. Min Jiang, Enbo Wang, Xiuli Wang, Aiguo Wu, Zhenhui Kang, Suoyuan Lian, Lin Xu, and Zhuang Li, Self-assembly of lacunary Dawson type polyoxometalates and poly(allylamine hydrochloride) multilayer films: photoluminescent and electrochemical behavior, Applied Surface Science, (2005), 242(1-2 ),199-206. Cited Times: 3. (SCI/EI)

35. K. Ted Thurn, Eric M. B. Brown, Aiguo Wu, Stefan Vogt, Barry Lai, Jörg Maser, Tatjana Paunesku, and Gayle E. Woloschak, Nanoparticles for Applications in Cellular Imaging, Nanoscale Research Letters (Review), (2007), 2, 430-441. Cited Times: 7. (SCI)

36. Kenneth T. Thurn, Tatjana Paunesku, Aiguo Wu, Eric M. B. Brown, Barry Lai, Stefan Vogt, Jörg Maser, Mohammed Aslam, Vinayak Dravid, Raymond Bergan, and Gayle E. Woloschak, Labeling TiO2 Nanoparticles with Dyes for Optical Fluorescence Microscopy and Determination of TiO2-DNA Nanoconjugate Stability, Small, (2009), 5(11), 1318-1325. (SCI)

2) Pre-Publications:

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1) Aiguo Wu , Tatjana Paunesku, and Gayle E. Woloschak, Nanotechnology and Radiation: The Interface-Nanoradiology, International Journal of Radiation Biology (Review), (2009), In preparation. 2) Aiguo Wu , Tatjana Paunesku, Kenneth T. Thurn, Baron Antone, Nicole Macheri,

Ioannis Koktzoglou, Rohan Dharmakumar, Andrew Larson, Reed Omary, Debiao Li, and Gayle E. Woloschak, Preparation of Magnetic Nanocrystals in Aqueous Solution in Air and Their Applications in Medical Magnetic Resonance Imaging (MRI), (2009), to be Submitted.

3) Aiguo Wu , Tatjana Paunesku, Zhuoli Zhang, Stefan Vogt, Barry Lai, Jörg Maser, Vahid Yaghmai, Debiao Li, and Gayle E. Woloschak, A Multimodal Nanocrystal and Its Potential Applications in Biomedical Imaging, (2009), to be Submitted.

3) Patents, pending patents (12) and invention disclosures (7):I) Patents

(1) A horizontally dynamical molecule combing (2002, Patent No.: CN 02104270.5)Aiguo Wu, Zhuang Li, Hualan Zhou, Jianping Zheng, and Erkang Wang (2) A preparing method of controllable DNA network (2002, Patent No. CN 02104271.3) Aiguo Wu, Zhuang Li, Jianping Zheng, Hualan Zhou, and Erkang Wang

(3) An AFM probe holder (1999, Patent No.: CN 99256948. 6)Zhuang Li, Aiguo Wu, Hongda Wang, and Lihua Yu

(4) An AFM controllable probe holder (2001, Patent No.: CN 01224491. 0)Zhuang Li, Aiguo Wu, Erkang Wang, and Lihua Yu

(5) An AFM multiprobes holder(2001, Patent No.: CN 01204082. 7)Zhuang Li, Aiguo Wu, Hongda Wang, and Lihua Yu

(6) A mechanical method for preparing controllable nanowire (2001, Patent No.: CN 01110205. 5)Zhuang Li and Aiguo Wu

(7) A physical chemistry method for preparing controllable nanowire (2001, Patent No.: CN 01110206.3)Zhuang Li, Aiguo Wu, Erkang Wang, and Lihua Yu

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(8) A relocated method for SPM samples (1999, Patent No.: CN 99126338. 3)Zhuang Li, Hongda Wang, Aiguo Wu, Lihua Yu, and Erkang Wang

(9) Preparation of controllable metal nanowire(2001, Patent No.: CN 01140159.1)Zhuang Li, Hualan Zhou, Aiguo Wu, Jianping Zheng, Jing Li, and Erkang Wang

II) Pending Patents

(1) An inputting method for Chinese first letter of the computer (2000, Applied No.: CN 00104585.7)Aiguo Wu, Zhuang Li, Hongda Wang, Lihua Yu, Jing Li, and Yonghai Song (2) A nanofluorescence dot method for super high-density information writing and reading (2001, Applied No.: CN 01118255. 5)Zhuang Li, Shifa Wu, Shi Pan, Aiguo Wu, Jian Zhang, Erkang Wang, Hualan Zhou, Yuqi Huang, Yinli Li, and Wei Sun

(3) A preparation method for gold film used as scanning probe microscope substrates (2004, Applied No.: CN 200410010647.9) Zhiguo Liu, Zhuang Li, Zhiyong Ma, Aiguo Wu, Hualan Zhou, and Gang Wei

(4) Multifunction Nanoconjugates for Imaging Applications and Targeted Treatment (U.S. Patent Application, March 13, 2009, NU27046)Inventors: Aiguo Wu, Tatjana Paunesku, and Gayle E. Woloschak

III) Invention Disclosures/Reports

(1) NU 26106: Method for locating cells on microscopy grids Inventors: Aiguo Wu, Gayle E. Woloschak(2) NU 26153: An approach to magnetic resonance imaging based on magnetic nanocrystals.

Inventors: Aiguo Wu, Tatjana Paunesku, and Gayle E. Woloschak (3) NU 26154: Preparation of magnetic nanocrystal materials and the formation process of magnetic nanocomposite materials.

Inventors: Aiguo Wu, Tatjana Paunesku, and Gayle E. Woloschak(4) NU 26171: Preparation of core-corona-shell nanocrystal materials and the formation process of nanocomposite materials

Inventors: Aiguo Wu, Tatjana Paunesku, and Gayle E. Woloschak(5) NU 26172: Preparation of core-shell nanocrystal materials based on metal components and the formation process of nanocomposite materials including metal elements

Inventors: Aiguo Wu, Tatjana Paunesku, and Gayle E. Woloschak

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(6) NU 27045: An approach to computed tomography based on nanomaterials with photoactive properties

Inventors: Aiguo Wu, Tatjana Paunesku, and Gayle E. Woloschak(7) NU 27046: An approach to computed tomography and magnetic resonance imaging obtained simultaneously based on nanomaterials

Inventors: Aiguo Wu, Tatjana Paunesku, and Gayle E. Woloschak4) Published Conference Proceedings and Abstracts (60 Total)

(1) Aiguo W u , Lihua Yu, Hongda Wang, and Zhuang Li, A relocated technique for AFM samples and its application in molecular biology. STM'6, Dec. 20-23, 2000, Xia-Men, China, P21 (in Chinese).(2) Aiguo W u , Lihua Yu, Hongda Wang, and Zhuang Li, Plasmid DNA network on a mica substrate investigated by AFM. STM'6, Dec. 20-23, 2000, Xia-Men, China, P16 (in Chinese). (3) Aiguo Wu, Yonghai Song, Zhuang Li, Lihua Yu, Bailin Zhang, and Erkang Wang, A DNA-based nanoparticles hybrid materials. ISEC’8, 2001, Chang-Chun, China, P263-264.(4) Aiguo Wu, Zhuang Li, Lihua Yu, and Erkang Wang, Preparing intact long strand DNA on mica. ISEC’8, 2001, Chang-Chun, China, P261-262.(5) Aiguo W u , Zhuang Li, Hualan Zhou, Jianping Zheng, and Erkang Wang, Preparing and characterizing DNA network by AFM. STM'7, Nov. 16-18, 2002, Shang-Hai, China, P1 (in Chinese). (6) Aiguo W u , Zhuang Li, Lihua Yu, Jianping Zheng, Hualan Zhou, Erkang Wang, and Huanming Yang, Long DNA strand investigated by AFM. STM'7, Nov. 16-18, 2002, Shang-Hai, China, P2 (in Chinese). (7) Aiguo W u , Zhuang Li, Wenlong Cheng, Hualan Zhou, Jianping Zheng, Yonghai Song, Junguang Jiang, and Erkang Wang, Metallized nanoparticles network assembled by DNA templates. STM'7, Nov. 16-18, 2002, Shang-Hai, China, P45-46 (in Chinese). (8) Aiguo Wu, Jianbo Jia, Zhuang Li, Junguang Jiang, Shaojun Dong, and Erkang Wang, Self-aggregation nanodisks of silver nanoparticels on bare mica substrates. BCEIA 2003, Bei-Jing, China, F159-160.(9) Aiguo Wu, Zhuang Li, and Erkang Wang, Molecular fractal of DNA investigated by atomic force microscopy. ISEC’9, 2003, Chang-Chun, China, P126-127.(10) Aiguo Wu and Norbert Hampp, Formation of nanoporous lipid arrays on mica by extraction of bacteriorhodopsins (BRs) from purple membrane (PM) patches. NanoBionics III-from molecules to applications, Apr. 4-8, 2005, Marburg/Giessen, Germany, P93.(11) Aiguo Wu, Koshonna Brown, Kenneth T. Thurn, Tatjana Paunesku, and Gayle E. Woloschak (Oral Presentation), Preparation of metal oxide nanocrystals in aqueous solution and their biocompatibility. American Chemical Society 234th National Meeting & Exposition, Aug. 19-23, 2007, Boston, MA USA (DIVISION: Division of Analytical Chemistry; SESSION: Analytical Approaches-Novel

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Materials).(12) Aiguo Wu, Tatjana Paunesku, Kenneth T. Thurn, Stefan Vogt, Barry Lai, Jörg Maser, Mohammed Aslam, Vinayak Dravid, and Gayle E Woloschak, Titanium dioxide-DNA nanocomposites: building blocks in material science and intracellular reagents in cell biology. Users Week 2007 for Argonne National Laboratory, May 7-12, 2007, Argonne, IL USA, p150. (13) Aiguo Wu, Tatjana Paunesku, Kenneth T. Thurn, Eric Brown, Mohammed Aslam, Vinayak Dravid, and Gayle E. Woloschak, Titanium dioxide nanoparticles assembled by DNA molecules. Third Annual Lewis Landsberg Research Day, March 7, 2007, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.(14) Aiguo Wu, Tatjana Paunesku, Kenneth T. Thurn, Eric Brown, Benjamin Haley,Stefan Vogt, Barry Lai, Jörg Maser, Mohammed Aslam, Vinayak Dravid, and Gayle E. Woloschak, Titanium dioxide-DNA nanocomposites: applications in material science and in cell biology. CCNE 2007, Oct. 16-18, 2007, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.(15) Aiguo Wu, Tatjana Paunesku, Nicole Mascheri, Kenneth T. Thurn, Eric, M. Brown, Debiao Li, and Gayle E. Woloschak (Oral Presentation), Preparation characterization, and applications of (super-) paramagnetic nanoparticles. Particles 2008 conference:  Particle Synthesis, Characterization, and Particle-Based Advanced Materials. May 10-13, 2008, Wyndham Orlando Resort, Orlando, Florida, USA. (16) Aiguo Wu , T Paunesku, N Mascheri, KT Thurn, EMB Brown, ZL Zhang, B Szolc-Kowalska, H Aurora, S Vogt, B Lai, J Maser, R Barrea, T Irving, V Yaghmai, D Li, A Larson, R Omary and GE Woloschak, Multicomponent nanoparticles/nanoconjugates for multimodally biomedical imaging. CCNE 2008 Site Visit, March 19, 2008, Northwestern University, Evanston, IL, USA.(17) Aiguo Wu, T Paunesku, N Mascheri, KT Thurn, EMB Brown, ZL Zhang, B Szolc-Kowalska, H Aurora, S Vogt, B Lai, J Maser, R Barrea, T Irving, V Yaghmai, D Li, A Larson, R Omary and GE Woloschak, Multicomponent nanoparticles/nanoconjugates for multimodally biomedical imaging. 19th Annual Scientific Poster Session, June 25, 2008, Robert H. Lurie Medical Research Building, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.(18) Aiguo Wu , Tatjana Paunesku, Nicole Mascheri, Kenneth T. Thurn, Eric M.B. Brown, Zhuoli Zhang, Hans Arora, Caroline Doty, Arielle Halpern, Debiao Li, and Gayle E. Woloschak, Investigation of TiO2 Coated (Super-)Paramagnetic Nanoparticles for Magnetic Resonance Imaging and Their Toxicity in Vitro. CCNE 2008, Sep. 8-10, 2008, Northwestern University Chicago, IL, USA.(19) Tatjana Paunesku, Aiguo Wu, Nicole Mascheri, Kenneth Thurn, Stefan Vogt, Barry Lai, Jörg Maser, Andrew Larson, Debiao Li, Reed Omary, and Gayle E. Woloschak, Testing different compositions of nanoconjugates for intracellular magnetic resonance imaging. Oct. 16-18, 2007, CCNE 2007, University of North Carolina at Chapel Hill, NC USA.(20) T Paunesku, Aiguo Wu, EMB Brown, N Mascheri, KT Thurn, S Vogt, B Lai, R Barrea, B Szolc-Kowalska, A Larson, S Arkani, G Karczmar, J Maser, T Irving, D Li, R Omary and GE Woloschak, X-ray fluorescence microscopy for evaluation of tissue

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targeting with nanoparticles. Second International Symposium on X-ray Phase Contrast Imaging (PCI), March 24-28, 2008, Yellow Mountain, Anhui, USA.(21) Gayle E Woloschak, Tatjana Paunesku, K Ted Thurn, Aiguo Wu, Stefan Vogt, Barry Lai, Jorg Maser, Introduction of TiO2-DNA nanocomposites in mammalian cells and detection using X-ray fluorescence microscopy. Second International Symposium on X-ray Phase Contrast Imaging (PCI), March 24-28, 2008, Yellow Mountain, Anhui, USA.(22) KT Thurn, T. Paunesku, Aiguo Wu, EMB Brown, H. Aurora, S. Vogt, B. Lai, J. Maser, GE Woloschak, Cellular Uptake Mechanisms of TiO2 Nanocomposites. CCNE 2008 Site Visit, March 19, 2008, Northwestern University, Evanston, IL, USA.(23) Eric M.B. Brown, Tatjana Paunesku, Aiguo Wu, Kenneth Thurn, Benjamin Haley, Taisa Priester, Cecille Cruz, Angela Babbo, Dan Jakubczak, Jimmy Clark, and Gayle E. Woloschak, Ability of titanium dioxide peptide nucleic acid nanocomposites to hybridize target DNA in vitro under pseudo-physiological ionic and temperature conditions. Oct. 16-18, 2007, CCNE 2007, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.(24) K. Ted Thurn, Tatjana Paunesku, Eric Brown, Aiguo Wu, Benjamin Haley, Barry Lai, Stefan Vogt, Jorg Maser, and Gayle E. Woloschak, Determining intracellular kinetics of TiO2-DNA using X-ray fluorescence microscopy. Oct. 16-18, 2007, CCNE 2007, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.(25) Eric Brown, Tatjana Paunesku, Kenneth Thurn, Benjamin Haley, Aiguo Wu, Taisa Priester, Cecille Cruz, Angela Babbo, Dan Jakubczak, and Gayle E. Woloschak, Determining the ability of TiO2-peptide nucleic acid-nanocomposites to cleave deleterious DNA. Third Annual Lewis Landsberg Research Day, March 7, 2007, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.(26) K. Ted Thurn, Tatjana Paunesku, Eric Brown, Aiguo Wu, Ben Harley, Barry Lai, Stefan Vogt, Jörg Maser, and Gayle E Woloschak, Combining X-ray induced X-ray fluorescence with fluorescent confocal microscopy. Users Week 2007 for Argonne National Laboratory, May 7-12, 2007, Argonne, IL USA, p147.(27) Lihua Yu, Aiguo W u , and Zhuang Li, Ni(phen)3

2+ fixing DNA investigated by AFM. STM'6, Dec. 20-23, 2000, Xia-Men, China, P15 (in Chinese).(28) Yongnian Ni and Aiguo W u , Simultaneous determination of mixtures of chloride, bromide, iodide and thiocyanate by potentiometric titration and chemometric approaches. ISWCSAC'98, Dec. 16th-18th, 1998, Hong Kong, China, 5-018(P259).(29) Zhuang Li, Hongda Wang, Aiguo W u , Lihua Yu, and Erkang Wang, DNA mapping by AFM. STM'6, Dec. 20-23, 2000, Xia-Men, China, P7 (in Chinese).(30) Lihua Yu, Zhuang Li, Aiguo W u , and Quanling Suo, Using AFM to image DNA and make DNA mapping. BCEIA 2001, Bei-Jing, China, F119-120.(31) Hongda Wang, Zhuang Li, Aiguo W u , Lihua Yu, and Huanming Yang, Preparing long DNA on mica for AFM imaging. BCEIA 2001, Bei-Jing, China, F97-98.(32) Hongda Wang, Zhuang Li, Aiguo W u , Lihua Yu, and Erkang Wang, Preparing controllable thickness inorganic salty nanofilm. BCEIA 2001, Bei-Jing, China, F117-

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118.(33) Lihua Yu , Zhuang Li, and Aiguo Wu, The topographical characterization of the surfactant by atomic force microscope. ISEC’8, 2001, Chang-Chun, China, P265-266.(34) Jianping Zheng, Zhuang Li, Aiguo W u , and Hualan Zhou, DNA condensation in cationic surfactant studied by AFM. STM'7, Nov. 16-18, 2002, Shang-Hai, China, P3-4 (in Chinese). (35) Jianping Zheng, Zhuang Li, Aiguo W u , and Hualan Zhou, Transitions of DNA conformation in Mg2+, Ca2+, and Sr2+ investigated by AFM. STM'7, Nov. 16-18, 2002, Shang-Hai, China, P5 (in Chinese). (36) Hualan Zhou, Zhuang Li, Aiguo W u , and Jianping Zheng, Synthesis of ZnO nanowire. STM'7, Nov. 16-18, 2002, Shang-Hai, China, P44 (in Chinese). (37) Hualan Zhou, Zhuang Li, Aiguo W u , and Jianping Zheng, Tip effects on scanning probe nanolithography. STM'7, Nov. 16-18, 2002, Shang-Hai, China, P124 (in Chinese). (38) Zhiguo Liu, Zhuang Li, Aiguo Wu, Jianping Zheng, Hualan Zhou, and Gang Wei, Different methods of immobilizing DNA on mica surface for atomic force microscopy imaging. BCEIA 2003, Bei-Jing, China, F153-154.(39) Gang Wei, Zhuang Li, Aiguo Wu, Jianping Zheng, Hualan Zhou, Zhiguo Liu, and Yonghai Song, The star activity sites of EcoRI on DNA strands without cations investigated by atomic force microscopy. BCEIA 2003, Bei-Jing, China, F155-156.(40) Hualan Zhou, Zhuang Li, Aiguo Wu, Jianping Zheng, Gang Wei, and Zhiguo Liu, Direct patterning of poly-L-lysine on mica by dip-pen nanolitjography. BCEIA 2003, Bei-Jing, China, F157-158.

(41) Hualan Zhou, Zhuang Li, Aiguo Wu, Jianping Zheng, Zhiguo Liu, and Gang Wei, Surface nanopatterning of histone calf thymus on mica by dip-pen nanolithography. ISEC’9, 2003, Chang-Chun, China, P160-161.

(42) Zhiguo Liu, Zhuang Li, Aiguo Wu, Jianping Zheng, Hualan Zhou, and Gang Wei, Artifacts on the mica surface. ISEC’9, 2003, Chang-Chun, China, P167-168.

(43) Yan Shen, Jianyun Liu, Aiguo Wu, Junguang Jiang, Baifeng Liu, Zhuang Li, and Shaojun Dong, Preparation of Pt nanoparticles multilayer films on glassy carbon electrode and electrocatalysis for dioxygen reduction. ISEC’9, 2003, Chang-Chun, China, P160-161.

(44) Shengyong Zhai, Aiguo Wu, Junguang Jiang, Jinghong Li, Preparation and film formation of photoluminescent organic-inorganic hybrid multilayers containing europium-substituted heteropolytunstate. ISEC’9, 2003, Chang-Chun, China, P269-270.

(45) K. Ted Thurn, Tatjana Paunesku, Eric Brown, Aiguo Wu, Benjamin Hale, Barry Lai, Stefan Vogt, Jörg Maser, and Gayle E Woloschak, Combining X-ray induced X-ray fluorescence with fluorescent confocal microscopy. the 2007 American Association for Cancer Research (AACR) Annual Meeting (Session Category: Chemistry 2; Session Title: Chemical Biology in Carcinogenesis, Therapy, and Drug Delivery), Apr. 14-18, 2007, Los Angeles, CA, USA.

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(46) Eric M.B. Brown, Tatjana Paunesku, Aiguo Wu, Kenneth Thurn, Benjamin Haley, Taisa Priester, Cecille Cruz, Angela Babbo, Dan Jakubczak, Jimmy Clark, and Gayle E. Woloschak, Ability of titanium dioxide peptide nucleic acid nanocomposites to hybridize target DNA in vitro under pseudo-physiological ionic and temperature conditions. CCNE 2007, Oct. 16-18, 2007, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. (47) Eric Brown, Tatjana Paunesku, Kenneth Thurn, Benjamin Haley, Aiguo Wu, Taisa Priester, Cecille Cruz, Angela Babbo, Dan Jakubczak, and Gayle E. Woloschak, Determining the ability of TiO2-peptide nucleic acid-nanocomposites to image and cleave deleterious DNA. Gordon Research Conference: Nucleosides, Nucleotides, and Oligonucleotides, Jul. 1-6, 2007, Salve Regina University, Newport, RI, USA. (48) Eric Brown, Tatjana Paunesku, Kenneth Thurn, Benjamin Haley, Aiguo Wu, Taisa Priester, Cecille Cruz, Angela Babbo, Dan Jakubczak, and Gayle E. Woloschak, Determining the ability of TiO2-peptide nucleic acid-nanocomposites to image and cleave deleterious DNA. CCNE 2007 Site Visit, Mar. 15, 2007, Northwestern University, Evanston, IL, USA.(49) Eric Brown, Tatjana Paunesku, Kenneth Thurn, Benjamin Haley, Aiguo Wu, Taisa Priester, Cecille Cruz, Angela Babbo, Dan Jakubczak, and Gayle E. Woloschak, Determining the Ability of TiO2-Peptide Nucleic Acid-Nanocomposites to Cleave Deleterious DNA. Northwestern University: Center for Drug Discovery and Chemical Biology Annual Symposium 2006, 2006, Northwestern University, Chicago, IL, USA.(50) Kenneth E. Thurn, Tatjana Paunesku, Eric Brown, Aiguo Wu, Stefan Vogt, Barry Lai, Jorg Maser, Gayle Woloschak, Nuclear localization of TiO2-nucleic acid nanocomposites for the targeting and imaging of malignant cells. 2008 AACR Annual Meeting, Poster Session: Chemical Aspects of Cancer: Targeting, Discovery, Delivery, and Detection, April 12-16, 2008, San Diego, CA, USA. (51) Eric M.B. Brown, Tatjana Paunesku, Aiguo Wu, K. Ted Thurn, Benjamin Haley, Taisa Priester, Jimmy Clark, Gayle E. Woloschak, Hybridization abilities of PNA-TiO2 bionanoconjugates. 2008 AACR Annual Meeting, Poster Session: Drug Delivery and Targeting, April 12-16, 2008, San Diego, CA, USA. (52) Kenneth E. Thurn, Tatjana Paunesku, Eric Brown, Aiguo Wu, Stefan Vogt, Barry Lai, Jorg Maser, Gayle Woloschak, Nuclear localization of TiO2-nucleic acid nanocomposites for the targeting and imaging of malignant cells. 19 th Annual Scientific Poster Session, June 25, 2008, Robert H. Lurie Medical Research Building, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.(53) Eric M.B. Brown, Tatjana Paunesku, Aiguo Wu, K. Ted Thurn, Benjamin Haley, Taisa Priester, Jimmy Clark, Gayle E. Woloschak, DNA Hybridization and Cleavage Abilities of PNA-TiO2 nanoconjugates. 19th Annual Scientific Poster Session, June 25, 2008, Robert H. Lurie Medical Research Building, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.(54) Arielle Halpern, Aiguo Wu, Tatjana Paunesku, Sunny Arkani, Mark P. Jensen, Eric M.B. Brown, Kenneth T. Thurn, Michuel Wanzer, Felix Richter, Greg Karczmar, and Gayle E. Woloschak, Distribution of CoFe2O4@TiO2 Nanoparticles Coated with Glucose in Three Month Old Transgenic Mice. CCNE 2008, Sep. 8-10, 2008,

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Northwestern University Chicago, IL, USA.(55) Eric M.B. Brown, Tatjana Paunesku, Aiguo Wu, K. Ted Thurn, Benjamin Haley, Jimmy Clark, Taisa Priester, Gayle E. Woloschak, Methods for Assessing DNA Hybridization of PNA-TiO2 Nanoconjugates and Evaluation of Their Capacities to Induce Site-Specific DNA Damage. CCNE 2008, Sep. 8-10, 2008, Northwestern University Chicago, IL, USA.(56) Kenneth Ted Thurn, Tatjana Paunesku, Eric M.B. Brown, Aiguo Wu, Barry Lai, Stefan Vogt, Jorg Maser, Gayle E. Woloschak, Uptake Mechanisms and Intracellular Trafficking of TiO2 Nanoparticles in Prostate Cancer PC3-M Cells. CCNE 2008, Sep. 8-10, 2008, Northwestern University Chicago, IL, USA.(57) Hans C. Arora, Aiguo Wu, Barbara Szolc-Kowalska, Kenneth T. Thurn, Jinju Lu, Stefan Vogt, Barry Lai, Tatjana Paunesku, Gayle E. Woloschak, Determining of TiO2–Doxorubicin Nanoconjugates for Enhanced Delivery and Cytotoxicity. CCNE 2008, Sep. 8-10, 2008, Northwestern University, Chicago, IL, USA.(58) John Boyle, Aiguo Wu, Hans C. Arora, Tatjana Paunesku, Gayle E. Woloschak, Use of Titanium-Dioxide Nanoparticles for Improved Cytotoxicity of Radiation Therapy in vitro. Medical Student Summer Research Program Poster Symposium, Oct. 23, 2008, Northwestern University, Chicago, IL, USA.(59) Hans C. Arora, Aiguo Wu, Barbara Szolc-Kowalska, Kenneth T. Thurn, Jinju Lu, Tatjana Paunesku, Gayle E. Woloschak, Use of titanium-oxide nanoparticles for improved delivery and effectiveness of doxorubicin in vitro. Northwestern University Feinberg School of Medicine Medical Scientist Training Program Annual Retreat, July 26-27, 2008, Chicago, IL, USA.(60) Hans C. Arora, Aiguo Wu, Barbara Szolc-Kowalska, Kenneth T. Thurn, Jinju Lu, Tatjana Paunesku, Gayle E. Woloschak, Use of titanium-oxide nanoparticles for improved delivery and effectiveness of doxorubicin in vitro. Radiation Research Society Annual Meeting, September 21-24, 2008, Boston, MA, USA.

Memberships and Service:

Member of American Chemistry Society, 2006- Member of American Microscopical Society, 2006- Member of Chinese Chemical Society, 2000-

Reviewers for International Journals:

Nano Letters, Nanomedicine, Nanoscale Research Letters, Nano, Materials, Food Chemistry, Radiation Research, Analytica Chimica Acta, Spectrochimica Acta Part-A Molecular and Biomolecular Spectroscopy, Bioconjugate Chemistry, Journal of Pharmaceutical and Biomedical Analysis, Clinical and Experimental Pharmacology and Physiology, Sensors, Luminescence, Journal of Biological Inorganic Chemistry.

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Invited Presentations/Seminars:

1. CAESAR, Bonn, Germany, November 23, 2004 Host: Professor Michael GiersigTitle: “Biomacromolecules, Nanoparticles and Their Interactions Investigated by Scanning Probe Microscopy (SPM)”

2. University of Twente, Enschede, Netherland, December 16, 2004Host: Professor David N. ReinhoudtTitle: “Various Nanostructures Based on Nanoparticles/Biomacromolecules Templates”

3. University of California at San Diego, San Diego, CA, USA, November 23, 2005Host: Professor Andrew KummelTitle: “Nanostructures Based on Nano/Bio Templates”

4. Duke University, Durham, NC, USA, January 06, 2006 Host: Professor Piotr E MarszalekTitle: “Atomic Force Microscopy (AFM) Studies of Biomacromolecules and Nanostructures”

5. Northwestern University, Chicago, IL, USA, January 22, 2006Host: Professor Gayle E WoloschakTitle: “Various Nanostructures Based on Nanoparticles/Bio-Templates”

6. University of Electronic Science and Technology of China (UESTC), Cheng-Du, China, May 29, 2008Host: Associate Professor Yiyao LiuTitle: “Simple Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-A Few Examples”

7. Yantai Institute of Coastal Zone Research for Sustainable Development, Chinese Academy of Sciences (YIC, CAS), Yan-Tai, China, May 31, 2008Host: Director/Professor Ping ShiTitle: “Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-Several Simple Examples”

8. Qingdao Institute of Biomass Energy and Bioprocess Technology, Chinese

Academy of Sciences (QIBEBT，CAS），Qing-Dao, China, June 2, 2008

Host: Deputy Director Xichao ZhaoTitle: “Investigations of Biomaterials, Nanoparticulate Materials and Their Interactions”

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9. Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences (SINANO, CAS), Su-Zhou, China, June 5, 2008Host: Professor Jiong LiTitle: “Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-Some Simple Examples”

10. China Ningbo Association for International Exchange of Personnel, Ning-Bo, China, June 9, 2008 (morning)Host: Director of China Ningbo Association for International Exchange of PersonnelTitle: “Applications of Nanoparticulate Materials in Biomedical Imaging”

11. Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences (NIMTE, CAS), Ning-Bo, China, June 9, 2008 (afternoon)Host: Director/Professor Ping CuiTitle: “Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-A Few Simple Examples”

12. University of Michigan, Ann Arbor, MI, USA, June 20, 2008 Host: Professor Xiaoqing PanTitle: “Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-A Few Simple Examples”

13. Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences (SINANO, CAS), Chicago, USA, July 22, 2008 (Internet Vision) Host: Director/Professor Hui Yang Title: “Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-A Few Simple Examples”

14. The Norwegian University of Science and Technology (NTNU), Trondheim, Norway, August 21, 2008 Host: Head/Professor Tor GrandeTrial Lecture: Nanostructured Materials for Energy TechnologyA Title for Research Topic: “Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-A Few Simple Examples”

15. The Norwegian University of Science and Technology (NTNU), Trondheim, Norway, August 22, 2008 North Solar Star Salon Lecture Host: Dr. Zhihong JiaTitle: “Applications of Nanoparticulate Materials in Chemistry, Biology, and Medicine-A Few Simple Examples”

16. National Center for Nanoscience and Technology, Beijing, China, December 22,

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2008 Host: Director/Professor Chen Wang & Dr. Sheng ZhongTitle: “Nanoparticulate Materials (NPMs) for Biomedical Imaging and Targeting Treatment”

17. DePaul University, Chicago, USA, February 19, 2009 Host: Professor Richard F. NiedzielaTitle: “Nanoparticle Materials for Applications in Chemistry, Biology & Medicine-Some Simple Cases”

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