cv-smith-2014-updated

Curriculum Vitae January 1, 2015 Charles J. Smith

Curriculum VitaeCharles Jeffrey Smith

Personal:

Current Positions: Associate ProfessorDepartment of RadiologyUniversity of Missouri School of MedicineOne Hospital DriveColumbia, Missouri 65211

Research Health ScientistResearch Service Division Room A005Harry S. Truman Memorial Veterans Hospital800 Hospital DriveColumbia, MO 65201-5297(573) 814-6000 ext. 53683

E-mail Address: [email protected]

Date of Birth: April 24, 1969

Place of Birth: Independence, Missouri

Citizenship: United States of America

Marital Status: Married to Monica Kay Meyer, October 29th, 2000

Children: Caitlyn and Morgyn Smith

Education:

Ph.D. in Chemistry: May, 1997University of MissouriColumbia, Missouri, 65211Dissertation Advisors: Kattesh V. Katti and Richard ThompsonDissertation Title: “Transition Metal Complexes of Novel, Polydentate, Water-Soluble, Phosphine Ligands”

B.S. in Chemistry: May, 1992Missouri State UniversitySpringfield, Missouri, 65897Advisors: Robert Ernst and Tamara Jahnke

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Professional Experience:

2013-present Faculty Advisor, Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, MO 65211

2014-present Research Health Scientist (Grade 14, Step 6), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201

2010-13 Research Health Scientist (Grade 14, Step 5), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201

2009-present Associate Professor, Department of Radiology, University of Missouri School of Medicine, Columbia, MO 65211

2009-present Research Associate Professor, Missouri University Research Reactor, Columbia, MO 65211

2009-2013 Adjunct Associate Professor, Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65211

2009-2013 Adjunct Associate Professor, Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO 65211

2005-2010 Research Scientist (Grade 13, Step 7), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201

2004-2009 Adjunct Assistant Professor, Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65211

2003-2009 Assistant Professor, Department of Radiology, University of Missouri-Columbia School of Medicine, Columbia, MO 65211

2003-2009 Research Assistant Professor, Missouri University Research Reactor, Columbia, MO 65211

2002-2009 Adjunct Assistant Professor, Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO 65211

2003-2005 Research Scientist WOC Appointment, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201

2003-2004 Research Assistant Professor, Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65211

2002-2006 Ambassador of the United States of America to the International Atomic Energy Agency

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I. RESEARCH/SCHOLARSHIP

Research Support:

1. Agency: United States Department of Veterans’ AffairsTitle: Targeted Radiotherapy/Chemotherapy Treatment of Prostate

CancerTotal Award: $648,346.00 Time Period: 04-01-13 to 03-31-17Project Role: Co-Investigator (5% Effort); T.J. Hoffman (PI on Program)

2. Agency: National Institute of Health 1-T32-OD011126Title: Postdoctoral Training in Comparative Medicine Total Award: $859,230.00Time Period: 07-19-2011 to 06-30-2016Project Role: Research Mentor; Craig Franklin (PI on Program)

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Completed Research Support:

1. Agency: University of Missouri Research Board ApplicationTitle: Novel Heteroligands for Prostate Cancer Diagnosis Total Award: $49,469.00Time Period: 03-01-2014 to 02-28-2015Project Role: Principal Investigator on Program

2. Agency: United States Department of EnergyTitle: Interrogation of Biological Systems: Training for the Development

of Novel RadiotracersTotal Award: $2,800,000.00Time Period: 11-01-2009 to 12-31-2014Project Role: Collaborator (0% Effort); Silvia Jurisson (PI on Project)

3. Agency: National Institute of Health 1-T32-EB004822-01A2Title: Graduate Training in Radiopharmaceutical Chemistry Total Award: $1,293,800.00Time Period: 09-01-2007 to 08-31-2014Project Role: Research Mentor; Silvia Jurisson and Susan Lever (PIs on

Program)

4. Agency: United States Department of DefenseTitle: Multimodal Imaging for Early Detection of Prostate CancerTotal Award: $283,500.00Time Period: 09-28-09 to 10-27-13Project Role: Co-Investigator (2.7% Effort); Lixin Ma (PI on Program)

5. Agency: United States Department of Veterans’ AffairsTitle: Preparation of Low-valent Tc/Re(I) Imaging/Therapeutic AgentsTotal Award: $91,128.00Time Period: 10-01-12 to 09-30-13Project Role: Principal Investigator (Bridge Funding Award)

6. Agency: United States Department of Veterans’ AffairsTitle: Preparation of Low-valent Tc/Re(I) Imaging/Therapeutic AgentsTotal Award: $736,800.00Time Period: 10-01-08 to 09-30-12Project Role: Principal Investigator on Program

7. Agency: United States Department of EnergyTitle: Functionalized PEI Nanoparticles for Delivery IGF-1R-targeted

siRNAs to uPAR-expressing Tumors In Vitro and In VivoTotal Award: $620,200.00Time Period: 09-15-2009 to 09-14-2012Project Role: Co-Investigator (5% Effort); Michael Giblin (PI on Project)

8. Agency: United States Department of Veterans’ AffairsTitle: Core Equipment Request for XS3DU MicrobalanceTotal Award: $13,683.00

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Time Period: 05-11-12Project Role: Principal Investigator on Program

9. Agency: University of Missouri Advantage Funds RequestTitle: Cancer Drug Development Center Automated

Radiopharmaceutical TechnologyTotal Award: $45,000.00Time Period: 04-01-2010 Project Role: Co-Investigator (0% Effort); Timothy J. Hoffman (PI on Project)

10. Agency: United States Department of Veterans’ AffairsTitle: Design and Synthesis of Ga/Cu-Labeled Imaging/Therapeutic

AgentsTotal Award: $854,740.00Time Period: 04-01-07 to 03-31-10Project Role: Collaborator (3% Effort); Michael Giblin (PI on Project)

11. Agency: National Cancer Institute Title: Development of [64Cu-NOTA-X-BBN(7-14)NH2] Conjugate: Novel

Targeting Vectors for Positron Emission Tomographic Imaging of Gastrin Releasing Peptide Receptor-Expressing Tissues

Total Award: $40,000.00 Project; $10,000,000.00 Total Program AwardTime Period: 07-01-07 to 07-31-09Project Role: Principal Investigator (3% effort); W.A. Volkert (PI on Program)

12. Agency: International Atomic Energy AgencyTitle: Program of Study for Dr. Pablo Cabral GonzalezTotal Award: $4,300.00Time Period: 06-02-09 to 09-02-09Project Rold: Principal Investigator on Project

13. Agency: National Institutes of HealthTitle: From Clinic to Bench and Back, Clinical Biodetective Training Total Award: $63,000.00 Project (Graduate Student Stipend, 3 Years);

$886,864 Total Program AwardTime Period: 07-01-2006 to 07-31-2009Project Role: Research Mentor for Ms. Lauren Retzloff; Mark Milanick (PI on

Program)

14. Agency: United States Department of Veterans’ AffairsTitle: Preparation of Low-valent Tc/Re(I) Imaging/Therapeutic AgentsTotal Award: $627,642.00Time Period: 04-01-05 to 03-31-08Project Role: Principal Investigator on Program

15. Agency: National Cancer Institute Title: Development of 3-Dimensional Fluorescence Molecular

Tomography for In Vivo Fusion Molecular ImagingTotal Award: $80,598.00 Project; $10,000,000.00 Total Program AwardTime Period: 08-01-05 to 07-31-07

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Project Role: Co-Investigator (3% effort); Ping Yu (PI on Project); W.A. Volkert (PI on Program)

16. Agency: National Cancer Institute Title: Development of GRP Receptor-Avid RadiopharmaceuticalsTotal Award: $1,095,500.00Time Period: 12-01-02 to 11-30-06Project Role: Co-Investigator (10% effort); T.J. Hoffman (PI on Program)

17. Agency: American Cancer SocietyTitle: Targeting Prostate Cancer with Peptide AnaloguesTotal Award: $715,974.00Time Period: 01-01-03 to 12-31-06Project Role: Co-Investigator (10% effort); T.J. Hoffman (PI on Program)

18. Agency: Harry S. Truman Memorial Veterans’ Hospital ResearchFoundation

Title: Mini-Proposal for Purchase of Symphony Quartet Peptide Synthesizer

Total Award: $40,000.00Time Period: 02-14-06Project Role: Co-Principal Investigator on Program

19. Agency: The University of Missouri-ColumbiaTitle: Prime Match for Purchase of Symphony Quartet Peptide

SynthesizerTotal Award: $20,000.00Time Period: 02-14-06Project Role: Co-Principal Investigator on Program

20. Agency: National Institute of Biomedical Imaging and BioengineeringTitle: Preparation of Low-valent Tc(I) Imaging AgentsTotal Award: $106,093.00 Project; $363,750.00 Total Program AwardTime Period: 09-01-04 to 08-31-06 (Remainder of Award Returned 3-31-05 Due

to Budgetary and Scientific Overlap with VA Merit Review Application)

Project Role: Principal Investigator on Program

21. Agency: National Cancer Institute DHHS-1P20-CA86290-1Title: Radiodiagnostic Agents for Primary and Metastatic Breast CancerTotal Costs: $90,000.00 Project; $887,237 Total Program AwardTime Period: 10-01-2000 to 09-30-2002Project Role: Co-Investigator (30% effort); T.J. Hoffman (PI on Project); W.A.

Volkert (PI on Program)

22. Agency: National Cancer Institute DHHS-1P20-CA86290-1Title: Assessment of the Utility of the Murine Polyomavirus Virion

Protein 1 (VP1) Pentamer as a Polyvalent Imaging AgentTotal Costs: $8,000.00 Project; $887,237.00 Total Program AwardTime Period: 06-01-2001 to 09-30-2002

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Project Role: Co-Investigator (2% effort); W.R. Folk (PI on Project); W.A. Volkert (PI on Program)

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Pending Research Support:

1. Agency: United States Department of Veterans’ AffairsTitle: Heterodimeric Molecular Vehicles for Prostate Cancer TargetingTotal Award: $870,832.00 Time Period: 04-01-15 to 03-31-19Project Role: Principal Investigator on Program

2. Agency: United States Department of DefenseTitle: Hetero Bivalent Targeting of Aggressive CaP for Improved

Diagnostic Assessment in Preclinical Models Total Award: $375,000.00 ($180,000.00 to MU)Time Period: 04-1-15 to 03-31-18Project Role: Co-Principal Investigator (10% Effort); Paul Benny (PI)

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Grants Submitted but not Funded:

1. Agency: National Institutes of HealthTitle: Bivalent Theranostic Probes Targeting Prostate Cancer DiseaseTotal Award: $1,456,878.00Time Period: 04-01-15 to 03-31-19Priority Score: 43, Percentile Rank of 46Project Role: Principal Investigator on Program

2. Agency: National Institutes of HealthTitle: Novel PET Agents Targeting Two Distinct Biomarkers of Prostate

CancerTotal Award: $865,535.00Time Period: 04-01-14 to 03-31-18Priority Score: Not DiscussedProject Role: Principal Investigator on Program

3. Agency: United States Department of DefenseTitle: Simultaneous Targeting of GRPR and PSMA for Improved

Diagnostic and Therapeutic Applications in Aggressive Prostate Cancer

Total Award: $375,000.00 ($206,375.00 to MU)Time Period: 04-01-14 to 03-31-17Priority Score: 2.8Project Role: Co-Principal Investigator (10% Effort); Paul Benny (PI)

4. Agency: University Partnership Foundation (PUF)Title: Research, Development, and Training in Isotope Production and

In Vivo Evaluation of Non-carrier Added Re-186Total Award: $293,686.00 Time Period: 04-01-13 to 03-31-16Priority Score: Discussed (Funding Mechanism Does Not Provide Scoring)Project Role: Co-Investigator (0% Effort); C.S. Cutler (PI on Program)

5. Agency: United States Department of Veterans’ AffairsTitle: Novel Radiotracers for Molecular Imaging of Human CancersTotal Award: $967,578.00 Time Period: 10-01-13 to 06-30-17Priority Score: 1.98, Percentile Rank of 29Project Role: Principal Investigator on Program

6. Agency: United States Department of Veterans’ AffairsTitle: Molecular Imaging of CancerTotal Award: $3,135,669.00 Time Period: 10-01-11 to 09-30-15Priority Score: 1.89Project Role: Principal Investigator on Project (38% Effort); T.J. Hoffman (PI on

Program)

7. Agency: National Institute of Biomedical Imaging and Bioengineering

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Title: Copper-64 Bombesin Targeting Vectors for PET Imaging of Gastrin Releasing Peptide Receptors

Total Award: $250,000 Time Period: 12-01-08 to 11-30-10Priority Score: Not DiscussedProject Role: Principal Investigator on Program

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Patents/Invention Disclosures, Honors, and Awards:

Patents/Invention Disclosures:

1. Katti, K.V.; Karra, S.R.; Berning, D.E.; Smith, C.J.; Volkert, W.A.; Ketring, A.R. “Hydroxymethyl Phosphine Compounds for Use as Diagnostic and Therapeutic Pharmaceuticals and Method of Making Same.” European Patent No. 1009447.

2. Hoffman, T.J.; Volkert, W.A.; Smith, C.J.; Gali, H.; Sieckman, G.L. “Gastrin Receptor-avid Peptide Conjugates.” United States Patent No. 7,060,247.

3. Katti, K.V.; Karra, S.R.; Berning, D.E.; Smith, C.J.; Volkert, W.A.; Ketring, A.R. “Hydroxymethyl Phosphine Compounds for Use as Diagnostic and Therapeutic Pharmaceuticals and Method of Making Same.” United States Patent No. 6,054,115.

4. Katti, K.V.; Karra, S.R.; Berning, D.E.; Smith, C.J.; Volkert, W.A.; Ketring, A.R. “Hydroxymethyl Phosphine Compounds for Use as Diagnostic and Therapeutic Pharmaceuticals and Method of Making Same.” United States Patent No. 5,855,867.

Peer-reviewed Professional Awards for Presentations at Meetings:

1. Vaslow, A.; Cai, Q.; Gallazzi, F.; Sieckman, G.; Smith, C.; Hoffman, T.; and Ma, L.; “In Vivo MRI Detection of GRP Receptors Using a High Affinity and Selectivity (Gd(DOTA))8Bombesin[7-14]NH2 Dendron for Targeting Prostate Cancer.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, April, 2012. (Awarded Young Investigator Award from the Missouri Foundation for Medical Research. Presenting Author: Vaslow, Research Mentor: Ma)

2. Vaslow, A.; Cai, Q.; Gallazzi, F.; Sieckman, G.; Smith, C.; Hoffman, T.; and Ma, L.; “In Vivo MRI Detection of GRP Receptors Using a High Affinity and Selectivity (Gd(DOTA))8Bombesin[7-14]NH2 Dendron for Targeting Prostate Cancer.” University of Missouri Life Sciences Week, Columbia, MO, April 16-20, 2012. (Awarded Best Undergraduate in Bioengineering and Informatics Division, University of Missouri Life Sciences Week. Presenting Author: Vaslow, Research Mentor: Ma )

3. Wienhoff, B.E.; Shaffer, S.M.; Lane, S.R.; Jurisson, S.S.; Brechbiel, M.W.; Nanda, P.K.; and Smith, C.J. “Site-directed Radiopharmaceutical Development for Treatment of Prostate Cancer.” The Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, June 2011. (Awarded 2nd Place in Student Technologist Section from the Society of Nuclear Medicine. Presenting Authors: Wienhoff/Shaffer, Research Mentor: Smith)

4. Nanda, P.K.; Jackson, A.B.; Rold, T.L.; Sieckman, G.L.; Szczodroski, A.F.; Hoffman, T.J.; and Smith, C.J. “Copper-64 Bombesin Conjugates for Specific Targeting of Human Cancers.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, May, 2011. (Awarded People’s Choice Award from the Missouri Foundation for Medical Research. Presenting Author: Nanda, Research Mentor: Smith)

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5. Nanda, P.K.; Pandey, U.; Rold, T.L.; Sieckman, G.L.; Figueroa, S.D.; Ma, L.; Hoffman, T.; and Smith, C.J. “In Vitro and In Vivo Evaluation of 64Cu-NO2A-X-BBN Antagonists as Potential Agents for Prostate Cancer Imaging.” The Society of Nuclear Medicine 57th Annual Meeting, Salt Lake City, Utah, June 2010. (Awarded Young Investigator’s Award from the Society of Nuclear Medicine. Presenting Author: Nanda, Research Mentor: Smith)

6. Nanda, P.K.; and Smith, C.J. “A New Series of Site Specific 64Cu-Bombesin Conjugates as Human Cancer Cell Imaging Agents.” 238th National Meeting of the American Chemical Society, Washington, D.C., August, 2009. (Awarded Young Investigator’s Award from the Society of Nuclear Medicine During the Probe Development in Molecular Imaging and Therapy Poster Session at the 238 th National Meeting of the American Chemical Society. Presenting Author: Nanda, Research Mentor: Smith)

7. Lane, S. “Potential Diagnostic Imaging Agents for GRPr-Expressing Prostate Cancer.” 26th Graduate Professional Council and Creative Activities Forum, Columbia, MO, March 7, 2009. (Awarded Second Place in the Physical Sciences Category. Presenting Author: Lane, Research Mentors: Jurisson and Smith)

8. Lane, S. Breckenridge/Lyon’s Outstanding Research Assistant Award. University of Missouri Department of Chemistry, 2009. (Research Mentors: Jurisson and Smith)

9. Lane, S.; Nanda, P.; and Prasanphanich A. “Prospective 64Cu-NOTA-X-Bombesin Conjugates for Prostate Cancer Imaging.” 25th Graduate Professional Council and Creative Activities Forum, Columbia, MO, March 8, 2008. (Awarded First Place in the Physical Sciences Category. Presenting Author: Lane, Research Mentors: Jurisson and Smith)

10. Prasanphanich, A.F.; Ma, L.; Yu, P.; Rold, T.L.; Hoffman, T.J.; Figueroa, S.D.; Sieckman, G.L.; and Smith, C.J. “Imaging of Human Breast and Prostate Cancer Xenografts Using Bombesin-based Molecular Imaging Probes.” University of Missouri Life Sciences Week, Columbia, MO, April 16-20, 2007. (Awarded Best Undergraduate in Biotechnology Division, University of Missouri Life Sciences Week. Presenting Author: Prasanphanich, Research Mentor: Smith )

11. Prasanphanich, A.; Nanda, P.K.; Rold, T.L.; Ma, L.; Hoffman, T.J.; Sieckman, G.L.; Figueroa, S.D.; and Smith, C.J. “Development of Highly Specific Radiopharmaceutical & Molecular Imaging Agents for Diagnosis of Human Cancers.” Washington, D.C., April 25, 2007. (Council on Undergraduate Research Posters on Capitol Hill Selection. Presenting Author: Prasanphanich, Research Mentor: Smith)

12. Prasanphanich, A.; and Smith, C.J. “Initial Evaluation of a New Series of Copper-64-NOTA-Bombesin Targeted Radiopharmaceuticals with PET Imaging Potential.” University of Missouri Health Sciences Research Day, Columbia, MO, November 10, 2006. (Awarded Second Place in Category I Health Sciences Research (Medical Students, Conley Scholars, and Undergraduates). Presenting Author: Prasanphanich, Research Mentor: Smith)

13. Balasubramanian, S.; Kujala, N.G.; Pacheco, D.; Yu, P.; Ma, L.; and Smith, C.J. “Designing a Frequency Domain Heterodyne System for 3D Diffused Photon

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Fluorescence Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 17-21, 2006. (Winners of Systems Biology, Modeling, and Technology Development Symposia)

14. Figueroa, S.D.; Winkelmann, C.T.; Rold, T. L.; Sieckman, G.L.; Smith, C.J.; and Hoffman, T.J. “Characterization of a Dual Head Pinhole SPECT/CT with Sub-millimeter Resolution for laboratory Animal Molecular Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 11-14, 2005. (Awarded Second Place in the Technology Development Research Category, University of Missouri Life Sciences Week. Presenting Author: Figueroa, Research Mentor: Hoffman)

15. Ketring, A.R.; Ehrhardt, G.J.; Embree, M.F.; Bailey, K.D.; Tyler, T.T.; Gawenis, J.A.; Jurisson, S.S.; Engelbrecht, H.P.; Smith, C.J.; and Cutler, C.S. “Production and Supply of High Specific Activity Radioisotopes for Radiotherapy Applications.” (Winners of the World Federation of Nuclear Medicine and Biology Clinical and Basic Science Award, 2002)

Honors:

1. Charles Jeffrey Smith, Selection to the Order of Socrates II for Excellence in Medical Education. University of Missouri School of Medicine, Office of Medical Education, Columbia, MO, June 30, 2009.

2. Charles Jeffrey Smith, Nomination for Gold Chalk Award. University of Missouri Graduate Professional Council, Columbia, MO, 2008.

3. Charles Jeffrey Smith, Who’s Who in America, 2006/2007.

4. Charles Jeffrey Smith, Special Emphasis Panel National Institute of Health. National Institute of Allergy & Infectious Diseases. “Radionuclide Decorporation Agents for Radiation/Nuclear Emergencies: Project Bioshield.” RFA-A1-06-030, 2006.

5. Charles Jeffrey Smith, Full Member in Sigma Xi (The Scientific Research Honor Society), 2006-present.

6. Charles Jeffrey Smith, United States Army Honorable Discharge, 1992.

7. Charles Jeffrey Smith, United States Air Force Mathematics and Science Award, 1987.

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List of Publications:

Peer-reviewed Professional Journal Articles:

1. Liu, D.; Balkin, E.R.; Jia, F.; Ruthengael, V.C.; Smith, C.J.; and Lewis, M.R. “Targeted Antisense Radiotherapy and Dose Fractionation Using a 177Lu-labeled Anti-BCL2 Peptide Nucleic Acid-Peptide Conjugate.” J. Nucl. Med., 2015, Submitted for Publication.

2. Smith, C.J. “Novel Agents for Molecular Imaging and Possible Therapy of Human Cancers.” Austin Journal of Nuclear Medicine and Radiotherapy, 2015, In Press.

3. Stott Reynolds, T.; Schehr, R.; Liu, D.; Xu, J.; Miao, Y.; Hoffman, T.J.: Rold, T.L.; Lewis, M.R.; and Smith, C.J.; “Characterization and Evaluation of a DOTA-conjugated Bombesin/RGD-Antagonists for Prostate Cancer Tumor Imaging and Therapy.” Nucl. Med. Biol., 2015, 42(2), 99-108.

4. Stott Reynolds, T.; Bandari, R.P.; Jiang, Z.; and Smith, C.J.; “Lutetium-177 Labelled Bombesin Peptides for Radionuclide Therapy.” Current Radiopharmaceuticals, 2015, In Press.

5. Suresh, D.; Zambre, A.; Chanda, N.; Hoffman, T.J.; Smith, C.J.; Robertson, D.J.; and Kannan, R. “Bombesin Peptide Conjugated Gold Nanocages Internalize via Clathrin Mediated Endocytosis.” Bioconjugate Chem., 2014, 25, 1565-1579.

6. Bandari, R.P.; Jiang, Z.; Stott Reynolds, T.; Bernskoetter, N.E.; Connors, J.P.; Szczodroski, A.F.; Bassuner, K.J.; Kirkpatrick, D.L.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith, C.J. “Synthesis and Biological Evaluation of Copper-64 Radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a Novel Bivalent Targeting Vector Having Affinity for Two Distinct Biomarkers (GRPr/PSMA) of Prostate Cancer.” Nucl. Med. Biol., 2014, 41(4), 355-363.

7. Durkan, K.; Jiang, Z.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; Bandari, R.J.; Szczodroski, A.F.; Liu, L.; Miao, Y.; Stott Reynolds, T.; and Smith, C.J. “A Heterodimeric [64Cu-NO2A-RGD-Glu-6-Ahx-RM2] αvβ3/GRPr-targeting Antagonist Radiotracer for PET Imaging of Prostate Tumors.” Nucl. Med. Biol., 2014, 41(2), 133-139.

8. Cai, Q-Y.; Yu, P.; Besch-Williford, C.; Smith, C.J.; Sieckman, G.; Hoffman, T.J.; and Ma, L. “Near-infrared Fluorescence Imaging of Gastrin Releasing Peptide Receptor Targeting in Prostate Cancer Lymph Node Metastases.” The Prostate, 2013, 73, 842-854.

9. Wienhoff, B.E.; Prasanphanich, A.; Lane, S.R.; Nanda, P.K.; Sieckman, G.L.; and Smith, C.J. “Synthesis and Selective Radiolabeling Strategies for Production of [90Y-DOTA-64Cu-NOTA-8-Aoc-BBN(7-14)NH2] Conjugate; a Dual Negatron/Positron Emitting Radioligand.” Journal of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-metal Compounds, 2013, 43(2), 178-184.

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10. Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Szczodroski, A.F.; Hoffman, T.J.; Rogers, B.E.; Wienhoff, B.E.; and Smith, C.J. “ Positron-emission Tomography (PET) Imaging Agents for Diagnosis of Human Prostate Cancer: Agonist Versus Antagonist Ligands.” In Vivo. International Journal of Experimental and Clinical Pathophysiology and Drug Research, 2012, 26, 583-592.

11. Shukla, R.; Nripen, C.; Zambre, A.; Katti, K.; Upendran, A.; Kulkarni, R.R.; Nune, S.; Casteel, S.W.; Smith, C.J.; Boote, E.; Robertson, J.D.; Kan, P.; Engelbrecht, H.; Watkinson, L.D.; Carmack, T.L.; Lever, J.R.; Cutler, C.; Caldwell, C.; Kannan, R.; and Katti, K.V. “Laminin Receptor Specific Gold Nanoparticles (198AuNP-EGCg) Show Efficacy in Treating Prostate Cancer.” Proceedings of the National Academy of Sciences USA, 2012, 109(31), 12426-12431.

12. Dijkgraaf, I.; Franssen, G.M.; McBride, W.J.; D’Souza, C.A.; Smith, C.J.; Goldenberg, D.M.; Oyen, W.J.G.; and Boerman, O.C. “PET Imaging of GRPR-expressing Tumors With an 18F-labeled Bombesin Analog.” J. Nucl. Med., 2012, 53(6), 947-952.

13. Nanda, P.K.; Pandey, U.; Bottenus, B.N.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith, C.J. “Bombesin Analogues for Gastrin-releasing Peptide Receptor Imaging.” Nucl. Med. Biol., 2012, 39, 461-471.

14. Jackson, A.B.; Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Szczodroski, A.F.; Hoffman, T.J.; Chen, X.; and Smith, C.J. “64Cu-NO2A-RGD-Glu-6-Ahx-BBN(7-14)NH2: A Heterodimeric Targeting Vector for Positron-emission Tomography Imaging of Prostate Cancer.” Nucl. Med. Biol., 2012, 39, 377-387.

15. Oliveira, E.A.; Faintuch, B.L.; Nunez, E.G.F.; Moro, A.M.; Nanda, P.K.; and Smith, C.J. “Radiotracers for Different Angiogenesis Receptors in a Melanoma Model.” Melanoma Research, 2012, 22(1), 45-53.

16. Faintuch, B.L.; Oliveira, E.A.; Fernandez, E.G.; Teodoro, R.; Moro, A.M.; Nanda, P.K.; and Smith, C.J. “Comparison of Two Peptide Radiotracers for Prostate Carcinoma Targeting.” Clinics, 2012, 67(2), 163-170.

17. Cutler, C.S.; Sisay, N.; Cantorias, M.; Galazzi, F.; Quinn, T.P.; and Smith, C.J. “Development of PET Molecular Targeting Agents with Gallium-68”. Radiochimica Acta, 2011, 99, 641-651.

18. Esteves, T.; Marques, F.; Paulo, A.; Rino, J.; Nanda, P.; Smith, C.J.; and Santos, I. “Multifunctional Tricarbonyl M(I) (M = Re, 99mTc) Complexes Bearing an Acridine Orange Intercalator and Bombesin Analogues: Synthesis, Characterization, and Cell Studies.” Journal of Biological Inorganic Chemistry, 2011, 16(8), 1141-1153.

19. Kannan, R.; Pillarsetty, N.; Gali, H.; Hoffman, T.J.; Volkert, W.A.; Barnes, C.L.; Jurisson, S.S.; Smith, C.J.; and Katti, K.V. “Design and Synthesis of a Bombesin Peptide-Conjugated Tripodal Phosphino Dithioether Ligand Topology for the Stabilization of fac-[M(CO)3]+ Core (M = 99mTc or Re).” Inorg. Chem., 2011, 50, 6210-6219.

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20. Chandra, N.; Kattumuri, V.; Shukla, R.; Zambre, A.; Katti, K.; Upendran, A.; Kulkarni, R.; Kan, P.; Fent, G.; Casteel, S.; Smith, C.J.; Boote, E.; Robertson, J.D.; Cutler, C.; Katti, K.; and Kannan, R. “Bombesin Functionalized Gold Nanoparticles Show In Vitro and In Vivo Cancer Receptor Specificity.” Proceedings of the National Academy of Sciences USA, 2010, 107(19), 8760-8765.

21. Lane, S.R.; Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Figueroa, S.D.; Hoffman, T.J.; Jurisson, S.S.; and Smith, C.J. “Optimization, Biological Evaluation, and MicroPET Imaging of Copper-64-Labeled Agonists, [64Cu-NO2A-X-BBN(7-14)NH2], in a Prostate Tumor Xenografted Mouse Model.” Nucl. Med. Biol., 2010, 37, 751-761.

22. Liu, D.; Overbey, D.; Watkinson, L.D.; Smith, C.J.; Figueroa, S.D.; Hoffman, T.J.; Forte, L.R.; Volkert, W.A.; and Giblin, M.F. “Comparative Evaluation of 64Cu-labeled E. Coli Heat-stable Enterotoxin Analogs for PET Imaging of Colorectal Cancer.” Bioconjugate Chem., 2010, 21, 1171-1176.

23. Chanda, N.; Kan, P.: Watkinson, L.D.; Shukla, R.; Zambre, A.; Carmack, T.L.; Engelbrecht, H.; Lever, J.R.; Katti, K.; Fent, G.M.; Casteel, S.W.; Smith, C.J.; Miller, W.H.; Jurisson, S.; Boote, E.; Robertson, J.D.; Cutler, C.; Dobrovolskaia, M.; Kannan, R.; Katti, K.V. “Radioactive Gold Nanoparticles in Cancer Therapy: Therapeutic Efficacy Studies of 198AuNP-GA Nanoconstruct in Prostate Tumor Bearing Mice.” Nanomedicine: Nanotechnology, Biology, and Medicine, 2010, 6(2), 201-209.

24. Retzloff, L.B.; Heinzke, L.; Figureoa, S.D.; Sublett, S.V.; Sieckman, G.L.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “Evaluation of [99mTc-(CO)3-X-Y-Bombesin(7-14)NH2] Conjugates for Targeting Gastrin Releasing Peptide Receptors Over-expressed on Breast Carcinoma.” Anticancer Research, 2010, 30(1), 19-30.

25. Nanda, P.K.; Lane, S.R.; Retzloff, L.B.; Pandey, U.S.; and Smith, C.J. “Radiolabeled Regulatory Peptides for Imaging and Therapy.” Current Opinion in Endocrinology and Diabetes, 2010, 17, 69-76.

26. Hoffman, T.J.; and Smith, C.J. “True Radiotracers: Copper-64 Targeting Vectors Based Upon Bombesin Peptide.” Nucl. Med. Biol., 2009, 36, 579-585.

27. Prasanphanich, A.; Retzloff, L.; Lane, S.R.; Nanda, P.K.; Sieckman, G.L.; Rold, T.L.; Ma, L.; Figueroa, S.D.; Sublett, S.V.; Hoffman, T.J.; and Smith, C.J. “In Vitro and In Vivo Analysis of [64Cu-NOTA-8-Aoc-BBN(7-14)NH2]: a Site-Directed Radiopharmaceutical for PET Imaging of T-47D Human Breast Cancer Tumors.” Nucl. Med. Biol., 2009, 36(2), 171-181.

28. Faintuch, B.L.; Teodoro, R.; Duatti, A.; Morganti, L.; Muramoto, E.; Faintuch, S.; and Smith, C.J. “Radiolabeled Bombesin Analogs for Prostate Cancer Diagnosis: Preclinical Studies.” Nucl. Med. Biol., 2008, 35, 401-411.

29. Lane, S.R.; Veerendra, B.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; Jurisson, S.S.; and Smith, C.J. “99mTc(CO)3-DTMA (DTMA = DIETHYLENETRIAMINE MONOACETATE) Bombesin Conjugates Having High Affinity for the GRP Receptor.” Nucl. Med. Biol., 2008, 35(3), 263-272.

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30. Prasanphanich, A.; Nanda, P.K.; Rold, T.L.; Ma, L.; Lewis, M.R.; Hoffman, T.J.; Sieckman, G.L.; Figueroa, S.D.; and Smith, C.J. “[64Cu-NOTA-8-Aoc-BBN(7-14)NH2] Conjugate: A Novel Targeting Vector for Positron Emission Tomographic Imaging of Gastrin Releasing Peptide Receptor-Expressing Tissues.” The Proceedings of the National Academy of Sciences USA, 2007, 104(30), 12462-12467.

31. Kunstler, J-U.; Veerendra, B.; Figueroa, S.D.; Sieckman, G.L.; Rold, T.L.; Hoffman, T.J.; Smith, C.J.; and Pietzsch, H.J. “Organometallic 99mTc(III) 4+1 Bombesin(7-14)NH2 Conjugates: Synthesis, Radiolabeling, and In Vitro/In Vivo Studies.” Bioconjugate Chem., 2007, 18, 1651-1661.

32. Ma, L.; Yu, P.; Veerendra, B.; Rold, T.L.; Retzloff, L.; Prasanphanich, A.; Sieckman, G.; Hoffman, T.J.; Volkert, W.A.; and Smith, C.J. “In Vitro and In Vivo Evaluation of Alexa Fluor 680-BBN[7-14]NH2 Peptide Conjugate; A High-affinity Fluorescent Probe Having High Selectivity for the GRP Receptor.” Molecular Imaging, 2007,6(3), 171-180.

33. Alves, S.; Correia, J.D.G.; Rold, T.L.; Prasanphanich, A.; Haubner, R.; Rupprich, M.; von Guggenberg, E.; Alberto, R.; Decristoforo, C.; Santos, I.; and Smith, C.J. “99mTc(CO)3-Pyrazolyl Conjugates of RGD: In Vitro and In Vivo Evaluation of [99mTcL(CO)3-Cyclo[Arg-Gly-Asp-D-Tyr-Lys]] (L = A Tridentate Pyrazolyl-based Chelating Ligand Framework).” Bioconjugate Chem., 2007, 18, 530-537.

34. Prasanphanich, A.; Lane, S.R.; Figueroa, S.D.; Ma, L.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; McCrate, J.M.; and Smith, C.J. “The Effects of Linking Substituents on the In Vivo Behavior of Site-directed, Peptide-based, Diagnostic Radiopharmaceuticals.” In Vivo. International Journal of Experimental and Clinical Pathophysiology and Drug Research, 2007, 21(2), 3-18.

35. Decristoforo, C.; Santos, I.; Pietzsch, H.J.; Duatti, A.; Smith, C.J.; Faintuch, B.L.; Rey, A.; Alberto, R.; von Guggenberg, E.; and Haubner, R. “Comparison of In Vitro and In Vivo Properties of 99mTc-RGD Peptides Labeled Using Different Novel Tc-cores.” The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2007, 51(1), 33-41.

36. Kannan, R.; Rahing, V.; Cutler, C.; Pandrapragada, R.; Katti, K.V.; Kattumuri, V.; Robertson, J.D.; Casteel, S.J.; Jurisson, S.; Smith, C.; Boote, E.; and Katti, K.V. “Nanocompatible Chemistry Toward Fabrication of Target-Specific Gold Nanoparticles.” Journal of the American Chemical Society, 2006, 128(35), 11342-11343.

37. Veerendra, B.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.; Retzloff, L.; McCrate, J.; Prasanphanich, A.; and Smith C.J. “Synthesis, Radiolabeling and In vitro GRP Receptor Targeting Studies of 99mTc-Triaza-X-BBN[7-14]NH2 (X = Serylserylserine, Glycylglycylglycine, Glycylserylglycine, or Beta Alanine).” Journal of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-metal Compounds, 2006, 36(6), 481-491.

38. Johnson, C.V.; Shelton, T.D; Smith,C.J.; Ma, L.; Perry, M.C.; Volkert, W.A.; and Hoffman, T.J. “Evaluation of Combined 177Lu-DOTA-8-AOC-BBN(7-14)NH2 GRP Receptor Targeted Radiotherapy and Chemotherapy in PC-3 Human Prostate Tumor

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Cell Xenografted SCID Mice.” Cancer Biotherapy & Radiopharmaceuticals, 2006, 21(2), 155-165.

39. Moustapha, M.E.; Ehrhardt, G.J.; Smith, C.J.; Szajek, L.; Eckelman, W.C.; and Jurisson, S.J. “Preparation of Cyclotron-Produced Re-186 and Comparison with Reactor-Produced Re-186 and Generator-Produced Re-188 for the Labeling of Bombesin.” Nucl. Med. Biol., 2006, 33(1), 81-89.

40. Alves, S.; Santos, I.; Bhadrasetty, V.; Correia, J.D.G.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.; Figueroa, S.D.; Retzloff, L.; McCrate, J.; Prasanphanich, A.; and Smith, C.J. “Pyrazolyl Conjugates of Bombesin: A New Tridentate Ligand Framework for Stabilization of the fac-MI(CO)3 Moiety.” Nucl. Med. Biol., 2006, 33(5), 625-634.

41. Smith, C.J.; Volkert, W.A.; and Hoffman, T.J. “Radiolabeled Peptide Conjugates for Targeting of the Bombesin Receptor Superfamily Subtype.” Nucl. Med. Biol., 2005, 32(7), 733-740.

42. Alves, S.; Paulo, A.; Correia, J.D.G.; Gano, L.; Smith, C.J.; and Santos, I. Pyrazolyl Derivatives as Bifunctional Chelators for Labeling Tumor-Seeking Peptides with the fac-[M(CO)3]+ Moiety (M = 99mTc, Re): Synthesis, Characterization, and Biological Behavior.” Bioconjugate Chem., 2005, 16(2), 438-449.

43. Giblin, M.F.; Veerendra, B.; and Smith, C.J. “Radiometallation of Receptor-Specific Peptides for Diagnosis and Treatment of Human Cancer.” In Vivo. New Anticancer Agents: In Vitro and In Vivo Evaluation (First Special Edition/Anticancer Research), 2005, 19, 9-30.

44. Faintuch B.L.; Santos R.L.S.R.; Souza A.L.F.M.; Hoffman T.J.; Greeley M.; and Smith C.J. “99mTc-HYNIC-Bombesin (7-14)NH2: Radiochemical Evaluation With Co-ligands EDDA (EDDA = Ethylenediamine-N,N’-diacetic Acid), Tricine, and Nicotinic Acid.” Journal of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-metal Compounds, 2005, 35, 43-51.

45. Miller, W.H.; Hartmann-Siantar, C.; Fisher, D.; Descalle, M-A.; Daly, T.; Lehmann, J.; Lewis, M.R.; Hoffman, T.J.; Smith, C.J.; Situ, P.D.; and Volkert, W.A. “Evaluation of Beta Absorbed Fractions in a Mouse Model for 90Y, 188Re, 166Ho, 149Pm, 177Lu, and 64Cu Radioisotopes.” Cancer Biotherapy & Radiopharmaceuticals, 2005, 20(4) 436-449.

46. Smith, C.J.; Volkert, W.A.; and Hoffman, T.J. “Gastrin Releasing Peptide (GRP) Receptor-Targeted Radiopharmaceuticals: A Concise Update.” Nucl. Med. Biol., 2003, 30, 861-868.

47. Ketring, A.R.; Ehrhardt, G.J.; Embree, M.F.; Bailey, K.D.; Tyler, T.T.; Gawenis, J.A.; Jurisson, S.S.; Engelbrecht, H.P.; Smith, C.J.; and Cutler, C.S. “Production and Supply of High Specific Activity Radioisotopes for Radiotherapy Applications.” Alasbimn Journal, 2003, 5(19), 1-7.

48. Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.L.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of [188Re(H2O)(CO)3-Dpr-SSS-

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Bombesin(7-14)NH2]: Syntheses, Radiolabeling, and In Vitro/In Vivo Studies Where Dpr = Diaminopropionic Acid.” Anticancer Research, 2003, 23(2), 63-70.

49. Hoffman, T.J.; Gali, H.; Smith, C.J.; Sieckman, G.L.; Hayes, D.L.; Owen, N.K.; and Volkert, W.A.; “Novel Series of Indium-111 Labeled Bombesin Analogues as Potential Radiopharmaceuticals for Specific Targeting of Gastrin Releasing Peptide (GRP) Receptors Expressed on Human Prostate Cancer Cells.” J. Nucl. Med., 2003, 44, 823-831.

50. Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.G.; Kannan, R.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of GRP Receptor-specific [99mTc(X)(CO)3- Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, Tumor-bearing, Rodent Models: Syntheses, Radiolabeling, and In Vitro/In Vivo Studies Where Dpr = 2,3-Diaminopropionic acid and X = H2O or P(CH2OH)3.” Cancer Research, 2003, 63, 4082-4088.

51. Smith, C.J.; Gali, H.; Sieckman, G.L.; Hayes, D.L.; Owen, N.K.; Mazuru, D.G.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of 177Lu-DOTA-8-BBN[7-14]NH2: An In Vitro/In Vivo Assessment of the Targeting Ability of this New Radiopharmaceutical for PC-3 Human Prostate Cancer Cells.” Nucl. Med. Biol., 2003, 30(3), 101-109.

52. Smith, C.J.; Gali, H.; Sieckman, G.L.; Higginbotham, C.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of 99mTc-N3S-X-BBN(7-14)NH2: An In Vitro/In Vivo Structure-Activity Relationship Study Where X = 0, 3, 5, 8, and 11-Carbon Tethering Moieties.” Bioconjugate Chem., 2003, 14, 93-102.

53. Li, W.P.; Smith, C.J.; Cutler, C.S.; Ketring, A.R; and Jurisson, S.S. “Aminocarboxylate and Octreotide Complexes with No Carrier Added 177Lu, 166Ho, and 149Pm.” Nucl. Med. Biol., 2003, 30, 241-251.

54. Cutler, C.S.; Smith, C.J.; Ehrhardt, G.J.; Tyler, T.T.; Jurisson, S.S.; and Deutsch, E. “Current and Potential Therapeutic Uses of Lanthanide Radioisotopes.” Cancer Biotherapy & Radiopharmaceuticals, 2000, 15(6), 531.

55. Katti, K.V.; Gali, H.; Smith, C.J.; and Berning, D.E. “Design and Development of Functionalized Water-Soluble Phosphines: Catalytic and Biomedical Implications.” Acc. Chem. Res., 1999, 32, 9.

56. Smith, C. J.; Reddy, V. S.; and Katti, K. V. “Different Coordination Modes of the New Water-Soluble Triphosphine (PhP[CH2CH2P(CH2OH)2]2) with Pt(II), Pd(II), Rh(I), and Re(V).” (FULL PAPER) J. Chem. Soc., Dalton Trans., 1998, 8, 1365.

57. Smith, C.J.; Li, N.; Katti, K.V.; Volkert, W.A.; and Ketring, A.R. “In Vitro and In Vivo Characterization of Novel, Water - Soluble, Dithio-bisphosphine 99mTc-Complexes.” Nucl. Med. Biol. 1997, 24, 685.

58. Smith, C.J.; Katti, K.V; Volkert, W.A.; and Barbour, L.J. “The Synthesis and Characterization of Chemically Flexible Water - Soluble Dithio–Bisphosphine Compounds: (HOH2C)2P(CH2)2S-(CH2)3S(CH2)2P(CH2OH)2, (HOH2C)2P(CH2)2-

S(CH2)3S(CH2)2P(CH2OH)2, and (HOH2C)2P(CH2)2S(CH2)3S(CH2)2P(CH2OH)2.

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Systematic Investigation of the Effect of Chain Length on the Coordination Chemistry of Rhenium(V). X-Ray Crystal Structures of [ReO2(HOH2C)2P(CH2)2S(CH2)3S-(CH2)2P(CH2OH)2]2(Cl)2, [ReO2(HOH2C)2P(CH2)2S(CH2)4S-(CH2)2P(CH2OH)2]2(ReO4

-)2, [ReO2(HOH2C)2P(CH2)3S(CH2)3S(CH2)3P(CH2OH)2](Cl).” Inorg. Chem. 1997, 36, 3928.

59. Smith, C.J.; Reddy, V.S.; Katti, K.V.; and Barbour, L.J. “The Synthesis and Coordination Chemistry of the First Water - Soluble Dithio-Bisphosphine Ligands [(HOH2C)2P(CH2)2S-X-S(CH2)2P(CH2OH)2] (X = (CH2)3 or C6H4). X-Ray Crystal Structure of [Pd(HOH2C)2P(CH2)2S(CH2)3S(CH2)2P(CH2OH)2](Cl)2.” Inorg. Chem. 1997, 36, 1786.

60. Smith, C.J.; Reddy, V.S.; and Katti, K.V. “New Advances in the Synthesis of a Water-Soluble Triphosphine and the Development of Tripodally Coordinated Rhodium(I) and Platinum(II) Complexes.” J. Chem. Soc., Chem. Commun. 1996, 2557.

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Book Chapters:

1. Volkert, W.A.; Quinn, T.P.; Smith, C.J.; and Hoffman, T.J. “Development of Receptor-avid Peptide Radiotracers for Targeting of Human Cancers.” Targeted Molecular Imaging M.J. Welch and W.C. Eckelman Eds., Taylor and Francis Group, LLC. 2012, 337-356.

2. Jackson, A.; Retzloff, L.; Nanda, P.; and Smith, C.J “Molecular Imaging of Breast Cancer Tissue via Site-directed Radiopharmaceuticals.” Breast Cancer Cells. S. J. Done Ed., INTECH, Rijeka, Croatia. Volume 5, 2011, 277-302.

3. Esteves, T.; Marques, F.; Rino, J.; Smith, C.J.; and Santos, I.; “Trifunctional Tricarbonyl Complexes for Cell-Specific and Nuclear Targeting.” Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. U. Mazzi, W.C. Eckelman, and W.A. Volkert Eds., SGE Editoriali, Padova, Italy. Volume 8, 2010, 395-396.

4. Nanda, P.K.; Pandey U.; Lane, S.; Sieckman, G.L.; Hoffman, T.J.; and Rold, T.; and Smith C.J. “A Comparative Study of 64Cu-NO2A-Bombesin Antagonist and Agonist Ligands.” Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. U. Mazzi, W.C. Eckelman, and W.A. Volkert Eds., SGE Editoriali, Padova, Italy. Volume 8, 2010, 579-582.

5. Nanda, P.K.; Prasanphanich, A.F.; Lane, S.R.; Retzloff, L.; Hoffman, T.J.; and Smith, C.J. “Tc-99m Conjugates of Bombesin for Specific Targeting and Molecular Imaging of Gastrin Releasing Peptide Receptor-Expressing Cancers.” Recent Advances of Bioconjugate Chemistry and Molecular Imaging. Dr. S.G. Pandalai Ed., Research Signpost, Kerala, India. 2008, 199-211.

6. Kunstler, J.-U.; Veerendra, B.; Sieckman, G.L.; Smith, C.J.; and Pietzsch, H.-J. “Organometallic Tc(III) Complexes for Bombesin Labeling.” Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. M. Nicolini, U. Mazzi Eds., SGE Editoriali, Padova, Italy. Volume 7, 2006, 317-318.

7. Veerendra, B.; Lane, S.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.; Retzloff, L.; Prasanphanich, A.; Jurisson, S.S.; and Smith C.J. “99mTc-(CO)3-DTMA (DTMA = Diethylenetriamineacetic Acid) Conjugates of Bombesin: A Novel Series of Peptide Conjugates Having Very High Affinity for the GRP Receptor Subtype 2.” Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. M. Nicolini, U. Mazzi Eds., SGE Editoriali, Padova, Italy. Volume 7, 2006, 319-320.

8. Miller, W. H.; Hartmann-Siantar, C.; Descalle, M.A.; Lehmann, J.; Lewis, M.R.; Hoffman, T.J.; Smith, C.J.; Situ, P. and Volkert, W.A. “Mouse Organ Absorbed Dose Fractions for Beta Emitters.” Trans. Am. Nucl. Soc., 2003, 89, 689-692.

9. Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.L.; Kannan, R.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of [99mTc(H2O)(CO)3-Dpr-(X)-Bombesin(7-14)NH2], a New Family of GRP-receptor Targeting Radiopharmaceuticals.” Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. M. Nicolini, U. Mazzi Eds., SGE Editoriali, Padova, Italy. Volume 6, 2002, 339.

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Professional Reports/Publications from the Proceedings of Meetings:

1. Kannan, R. Hoffman, T.J.; and Smith, C.J. “Chemo Without the Side-effects: Scientists Look to Gold, Toad Skin for Answers.” VA RESEARCH CURRENTS, Research News from the United States Department of Veterans Affairs, September 25, 2014.

2. Smith, C.J.; Nanda, P.K.; Ma, L.; Stott Reynolds, T.; Hoffman, T.J.; Bernskoetter, N.E. and Jiang, Z. “Molecular Imaging Probes Based Upon Bombesin Peptide.” Amino Acids; The Forum for Amino Acid, Peptide, and Protein Research, 2013, 45(3), 608.

3. Shukla, R.; Zambre, A.; Chandra, N.; Kan, P.; Engelbrecht, H.; Cutler, C.S.; Lever, J.R.; Smith, C.J.; Caldwell, C.W.; Katti, K.; Upendran, A.; Kannan, R.; and Katti, K.V. “Clinical Translation of Radioactive Gold Nanoparticle-based Nanoceutical (EGCG-198AuNP) for Prostate Tumor Therapy.” J. Labeled Compd. Radiopharm., 2011, O-089.

4. Laverman, P.; Dijkgraaf, I.; McBride, W.J.; D’Souza, C.A.; Eek, A.; Smith, C.J.; Sharkey, R.M.; Oyen, W.J.G.; Goldenberg, D.M.; and Boerman, O.C. “Improvement of Al18F-labeling of Peptides and In Vivo Characterization.” J. Labeled Compd. Radiopharm., 2011, P-370.

5. McLaughlin, M.; Chanda, N.; Lever, J.R.; Smith, C.J.; Kannan, R.; Katti, K.; Katti, K.V.; and Cutler, C.S. “Evaluation of Receptor Affinity of Au-198-Starch-Nanoparticles Conjugated to Bombesin.” J. Labeled Compd. Radiopharm., 2011, P-460.

6. Jackson, A.B.; Nanda, P.K.; Sieckman, G.L.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “A comparison of Monomeric, Multimeric, and Bivalent Site-directed 64Cu-peptide Conjugates for Molecular Imaging of Human Cancers.” J. Labeled Compd. Radiopharm., 2011, P-077.

7. Ma, L.; Smith, J.; Cai, Q.; Nanda, P.; Price, S.; and Zhai, H. “Multimodal Imaging for Early Detection of Prostate Cancer.” Proceedings of Innovated Minds in Prostate Cancer Today (IMPaCT), 2011, P21-11.

8. Lane, S.; Nanda, P.; Prasanphanich, A.; Sieckman, G.; Rold, T.; Ma, L.; Figueroa, S.; Sublett, S.; Hoffman, T.; and Smith C. “In Vitro and In Vivo Evaluation of [64Cu-NO2A-(X)-BBN(7-14)NH2] Radiopharmaceuticals for Potential PET Imaging of Human Prostate Cancer.” J. Labeled Compd. Radiopharm., 2009, S457.

9. Kan, P.; Engelbrecht, H.P.; Watkinson, L.D.; Carmack, T.L.; Lever, J.R.; Smith, C.J.; Kannan, K.V.; Katti, K.V.; Jurisson, S.S.; and Cutler, C.S. “Evaluation of Gum Arabic Stabilized Gold-198 Nanoparticles in Prostate Cancer Bearing Mice.” J. Labeled Compd. Radiopharm., 2009, S521.

10. Lewis, M.R.; Prasanphanich, A.F.; Retzloff, L.; Lane, S.R.; Nanda, P.R.; Sieckman, G.L.; Rold, T.L.; Ma, L.; Figueroa, S.D.; Sublett, S.V.; Hoffman, T.J.; and Smith, C.J. “In Vitro and In Vivo Evaluation of [(Cu)-64-NOTA-AOC-BBN(7-14)NH2]

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Radiopharmaceutical for PET Imaging of Human Breast and Prostate Cancer Tumors.” Anticancer Research, 2008, 28, 401, 3377.

11. Kujala, N.; Zhai, H.; Smith, C.J.; Prasanphanich, A.; Sieckman, G.; Hoffman, T.; Volkert, W.; Ma, L.; and Yu, P. “A New Near-infrared Absorption and Fluorescent Probe Based on Bombesin for Molecular Imaging.” Proc. SPIE, Volume 7190, 2009, 1-9.

12. Ma, L.; Brown, A.; Kujala, N.; Smith, C.J.; Figueroa, S.D.; Yu, P.; Hoffman, T.J.; and Volkert, W.A. “Functional Apparent Diffusion Mapping the Uptake of Tumor-Targeting Bombesin Probes in Human Breast and Prostate Cancer Xenografts.” Proc. Intl. Soc. Mag. Reson. Med. 2008, 16, 2813.

13. Prasanphanich, A.; Nanda, P.K.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “Evaluation of a New Series of Copper-64-Bombesin Targeted Radiopharmaceuticals with PET Imaging Potential.” J. Labeled Compd. Radiopharm., 2007, 50(1), S338.

14. Santos, I.; Fernandes, C.; Alves, S.; Galamba, J.; Gano, L.; Pirmettis, I.; Decristoforo, C.; Smith, C.J.; and Alberto, R. “Labeling of Qunazoline and RGD-peptides with the [99mTc(CO)3]+ Core: Synthesis, Characterization, and Biological Evaluation.” Report of the Third Research Co-ordination Meeting on Development of Tc-99m Based Small Molecules Using Novel Tc-99m Cores. A Technical Report of the International Atomic Energy Association (SERIES 459), Budapest, Hungary, 2007, 219-231.

15. Alves, S.; Correia, J.D.G.; Santos, I.; Decristoforo, C.; Alberto, R.; and Smith, C.J. “In Vitro and In Vivo Evaluation of [99mTc(CO)3-Cyclo[Arg-Gly-Asp-D-Tyr-Lys(PZ1)].” Report of the Third Research Co-ordination Meeting on Development of Tc-99m Based Small Molecules Using Novel Tc-99m Cores. A Technical Report of the International Atomic Energy Association (SERIES 459), Budapest, Hungary, 2007, 287-302.

16. Cheng, K.T.; Smith, C.J.; Ma, L.; Yu, P.; and Hoffman, T.J. Alexa Fluor 680-glycylglycylglycine-bombesin[7-14]NH2 Peptide. Alexa Fluor 680-G-G-G-BN[7-14]NH2. Molecular Imaging and Contrast Agent Database (MICAD). National Library of Medicine (Bethesda, MD, USA), NCBI; 2007.

17. Balasubramanian, S.; Carmignani, B.; Kujala, N.G.; Ma, L.; Smith, C.J.; and Yu, P. “Using Fluorescence Molecular Tomography for Multimodality Fusion Imaging.” Proc. SPIE, Volume 6431, 2007, 643110.

18. Hoffman, T.J.; Rold, T.L.; Figueroa, S.D.; Sieckman, G.L.; Garrison, G.C..; Winkelmann, C.T.; Smith, C.J.; Perry, M.C.; and Volkert, W.A. “The Gastrin Releasing Peptide Receptor (BB2r) as a Potential Target for Diagnostic and Therapeutic Radiopharmaceuticals.” Proceedings of the UICC World Cancer Congress, 2007, 63-67.

19. Katti, K.; Kannan, R.; Kattumori, V.; Pandrapraganda, R.; Rahing, V.; Cutler, C.; Boote, E.; Casteel, S.; Smith, C.; Robertson, J.; Jurrison, S. “Hybrid Gold

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Nanoparticles in Molecular Imaging and Radiotherapy.” Czechoslovak Journal of Physics, 2006, 56, D23-D34, Suppl. 4.

20. Ehrhardt, G.J.; Moustapha, M.E.; Smith, C.J.; Szajek, L.; Eckelman, W.C.; and Jurisson, S.J. “Preparation of Cyclotron Re-186 and Comparison with Reactor Re-186 and Generator Re-188 for the Labeling of Bombesin.” J. Labeled Compd. Radiopharm., 2005, 48(1), S16.

21. Smith, C.J.; Alves, S.; Santos, I.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.; Retzloff, L.; McCrate, J.; Prasanphanich, A.; and Bhadrasetty, V. “Technetium(I) Pyrazolyl Bombesin Conjugates: A Concise InVitro/In Vivo Study.” J. Labeled Compd. Radiopharm., 2005, 48(1), S46.

22. Ma, L.; Smith, C.J.; Sieckman, G.L.; Volkert, W.A.; and Hoffman, T.J. “Structural

Characterization of DOTA-8-Aoc-Bombesin(7-14)NH2 Analogue Using Nuclear Magnetic Resonance Spectroscopy.” J. Labeled Compd. Radiopharm., 2005, 48(1), S324.

23. Alves, S.; Correia, J.D.G.; Santos, I.; Decristoforo, C.; Alberto, R.; and Smith, C.J. “In Vitro and In Vivo Evaluation of [99mTc(CO)3-Cyclo[Arg-Gly-Asp-D-Tyr-Lys(PZ1)].” Report of the Second Research Co-ordination Meeting on Development of Tc-99m Based Small Molecules Using Novel Tc-99m Cores. An Internal report of the International Atomic Energy Association, Vienna, Austria, 2004, 124-138.

24. Duatti, A.; Smith, C.J.; Decristoforo, C.; Alberto, R.; Kornyei, J.; Santos, I.; Kothari, K.; Faintuch, B.; Pietzsch, H.J.; Pirmettis, I.; Rios, A.; Suglobov, D.; and Narasimhan, D.V.S. Report of the First Research Co-ordination Meeting on Development of Tc-99m Based Small Molecules Using Novel Tc-99m Cores. An Internal Report of the International Atomic Energy Association, Ferrara, Italy, 2003.

25. Duatti, A.; Smith, C.J.; Schibli, R.; Alberto, R.; Schubiger, P.A.; Santos, I.; Verbruggen, A.; and Narasimhan, D.V.S. Report of a Consultants’ Meeting on Recent Advances in Tc-99m Labeling of Small Molecules Using Novel Tc-99m Cores. An Internal Report of the International Atomic Energy Association, Zurich, Switzerland, 2002.

26. Smith, C.J.; Hoffman, T.J.; Gali, H.; Hayes, D.L.; Owen, N.K.; Sieckman, G.L.; and Volkert, W.A. “Detailed Radiochemical Investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH2: A New Gastrin Releasing Peptide Receptor (GRPr) Targeting Radiopharmaceutical.” J. Labeled Compd. Radiopharm., 2001, 44(1), S706.

27. Katti, K.V.; Berning, D.E.; Smith, C.J.; and Gali, H. “Construction of Water-Soluble Phosphines. New Advances in Aqueous Organometallic Chemistry.” Phosphorus, Sulfur, and Silicon and the Related Elements, 1999, 144-146, 461.

28. Smith, C.J.; Higginbotham, C.; Katti, K.V.; and Volkert, W.A. “Rhodium-105 Complexes of Polydentate, Aqueous-soluble, Phosphine Ligands: New Radiochemical Developments Towards Radioimmunotherapy.” Phosphorus, Sulfur, and Silicon and the Related Elements, 1999, 144-146, 481.

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29. Smith, C.J.; Katti, K.V.; Higginbotham, C.; Volkert, W.A.; and Ketring, A.R. “In Vivo Studies of Tc-99m Complexes Derived From New Water-Soluble Dithio(hydroxymethyl)bisphosphines (P2S2).” J. Labeled Compd. Radiopharm., 1997, 40[S1], 444.

30. Katti, K.V.; Reddy, V.S.; Sing, P.R.; Berning, D.E.; Smith, C.J.; Volkert, W.A.; and Ketring, A.R. “New Directions in the Development of Water-Soluble Phosphines and Transition Metal Compounds.” Phosphorus, Sulfur, and Silicon and the Related Elements, 1996, 111(1-4), 699.

Peer-reviewed Abstracts:

1. Bandari, R.P.; Stott Reynolds, T.; Jiang, Z.; and Smith C.J. “Novel, Multivalent Tracers Targeting Prostate Cancer Biomarkers.” Nucl. Med. Biol., 2014, 41(7), 639.

2. Cai, Q.; Besch-Williford, C.; Yu, P.; Smith, C.J.; Hoffman, T.J.; and Ma, L. “In Vivo Near-Infrared Fluorescence Imaging of Primary and Metastatic Prostate Cancer.” J. Nucl. Med., 2012, 53, 24, Suppl. 1.

3. Ma, L.; Cai., Q.; Nanda, P.K.; Smith, C.J.; Hoffman, T.J.; Yu, P.; and Volkert, W.A. “MRI and Near-infrared Fluorescence Imaging of Gastrin Releasing Peptide Receptor-expressing Tumors.” J. Nucl. Med., 2011, 52, 1550, Suppl. 1.

4. Dijkgraaf, I.; Franssen, G.; McBride, W.; D’Souza, C.; Smith, C.J.; Goldenberg, D.; Oyen, W.; and Boerman, O. “Targeting GRPR-expressing Tumors with an 18F-labeled Bombesin Analogue.” J. Nucl. Med., 2011, 52, 297, Suppl. 1.

5. Jackson, A.B.; Nanda, P.K.; Sieckman, G.L.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “Site-directed Molecular Imaging of Human Cancers via Multimeric Conjugates.” J. Nucl. Med., 2011, 52, 1523, Suppl. 1.

6. Wienhoff, B.E.; Shaffer, S.M.; Lane, S.R.; Jurisson, S.S.; Brechbiel, M.W.; Nanda, P.K.; and Smith, C.J. “Site-directed Radiopharmaceutical Development for Treatment of Prostate Cancer.” J. Nucl. Med., 2011, 52, 2456, Suppl. 1.

7. Oliveira, E.A.; Faintuch, B.L.; Fernandez, E.G.; Santos, R.P.S.; Silva, N.G.; Targino, R.; Moro, A.M.; and Smith, C.J. “99mTc-MAG3-PEG8-c(RGDYK) Uptake in Melanoma Tumor.” J. Nucl. Med., 2011, 52, 1520, Suppl. 1.

8. Nanda, P.K.; Pandey, U.; Bottenus, B.N.; Lane, S.R.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith C.J. “Comparative Study of 64Cu and 67Ga-Bombesin Antagonists as Potential Agents for Prostate Cancer Imaging.” Abstracts of Papers of the American Chemical Society 240, 2010, NUCL-146.

9. Faintuch, B.L.; Fernandez, E.; Teodoro, R.; Wiecek, D.; Agarbuio, A.; Moro, A.; and Smith, C.J. “99mTc-SAMA-GGG-Ahx-BBN for GRP Receptor Targeting.” J. Nucl. Med., 2010, 51, 308P, Suppl. 2.

10. Kan, P.; Engelbrecht, H.; Shukla, P.R.; Lever, J.R.; Smith, C.J.; Kannan, R.; Katti, K.V.; Jurisson, S.S.; Cutler, C.S. “In Vivo Evaluation of EGCG Stabilized Gold-198

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Nanoparticles in Prostate Cancer Bearing Mice.” J. Nucl. Med., 2010, 51, 311P, Suppl. 2.

11. Smith C.J.; Nanda, P.K.; Lane, S.; Sieckman, G.L.; Hoffman, T.J.; and Rold, T.; “A Comparative Study of 64Cu-NO2A-Bombesin Antagonist and Agonist Ligands.” Nucl. Med. Biol., 2010, 37, 725.

12. Esteves, T.; Marques, F.; Rino, J.; Smith, C.J.; and Santos, I.; “Trifunctional Tricarbonyl Complexes for Cell-Specific and Nuclear Targeting.” Nucl. Med. Biol., 2010, 37, 710.

13. Nanda, P.K.; Pandey, U.; Rold, T.L.; Sieckman, G.L.; Figueroa, S.D.; Ma, L.; Hoffman, T.; and Smith, C.J. “In Vitro and In Vivo Evaluation of 64Cu-NO2A-X-BBN Antagonists as Potential Agents for Prostate Cancer Imaging.” J. Nucl. Med., 2010, 51, 24P, Suppl. 2.

14. Nanda, P.K.; and Smith, C.J. “A New Series of Site Specific 64Cu-Bombesin Conjugates as Human Cancer Cell Imaging Agents.” Abstracts of Papers of the American Chemical Society 238, 2009, INOR-631.

15. Wiecek, D.; Faintuch, B.L.; Teodoro, R.; Fernandez, E.G.; and Smith, C.J. “Radiolabeling and Biodistribution Studies of the New Angiogenesis Tracer Cyclic ASn-Gly-Arg (NGR).” J. Nucl. Med., 2009, 50, 215P, Suppl. 2.

16. Karacay, H.; McBride, W.J.; Sharkey, R.M.; Cardillo, T.; Smith, C.J.; and Goldenberg, D.M. “18F Labeling of a Peptide for PET Imaging of Receptor-expressing Tumors.” J. Nucl. Med., 2009, 50, 1567, Suppl. 2.

17. Decristoforo, C.; Rey, A.; Kuenstler, J.U.; Pietzsch, H.J.; Correia, J.D.G.; Santos, I.; Smith, C.J.; Faintuch, B.L.; Hernandez-Gonzales, I.; Rupprich, M.; Alberto, R.; and Haubner, R. “Comparison of In Vitro and In Vivo Properties of 99mTc-RGD Peptides for Targeting Tumor Angiogenesis, Labeled Using Different Novel Technetium-cores.” The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2006, 1(1), Supplement 1, 20.

18. Figueroa, S.D.; Winkelmann, C.; Miller, W.; Rold, T.; Sieckman, G.; Smith, C.; Ma, L.; Garrison, J.; Volkert, W.; and Hoffman, T. “TLD-100 Measurement and Assessment of Internal Mouse Dosimetry During Micro-CT Analysis.” Medical Physics, 2006, 128(35), 2211.

19. Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Atkinson, L.A.; Volkert, W.A.; and Hoffman, T.J. “Design and Development of Tc-99m-Carbonyl-Bombesin Analogs: A Structure Activity Relationship Study.” J. Nucl. Med., 2003, 44(5), 298P, Suppl. S.

20. Hoffman, T.J.; Smith, C.J.; Gali, H.; Owen, N.K.; Sieckman, G.L.; Foster, B.N.; Mazuru, D.G.; Shelton, T.D.; and Volkert, W.A. “Preclinical Evaluation of Y-90 and Lu-177 Radiolabeled Peptides for In Vivo Targeted Radiotherapy of Prostate Cancer.” International Journal of Cancer, 2002, 462-432, Suppl. 13.

21. Papagiannopoulou, D.; Raghuraman, K.; Pillarsetty, N.; Katti, K.V.; Smith, C.J.; Hoffman, T.J.; Owen, N.; Greeley, M.; and Jurisson, S. “Synthesis and Biological

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Evaluation of Novel Tc-99m Tricarbonyl Complexes with Amine Ligands.” J. Nucl. Med., 2002, 43(5), 375P, Suppl. S.

22. Gali, H.; Smith, C.J.; Hoffman, T.J.; Sieckman, G.L.; Hayes, D.L.; Owen, N.K.; and Volkert, W.A. “Influence of the Radiometal on the In Vivo Pharmacokinetic Properties of a Radiometal-Labeled DOTA-Conjugated Peptide.” Abstracts of Papers of the American Chemical Society 222, 2001, U569-U570, Part 1.

23. Hoffman, T.J.; Smith, C.J.; Gali, H.; Owen, N.K.; Sieckman, G.L.; Hayes, D.L.; and Volkert, W.A. “Development of a Diagnostic Radiopharmaceutical for Visualization of Primary and Metastatic Breast Cancer.” J. Nucl. Med., 2001, 42(5), 254P, Suppl. S.

24. Hoffman, T.J.; Smith, C.J.; Gali, H.; Owen, N.K.; Sieckman, G.L.; Hayes, D.L.; Foster, B.; and Volkert, W.A. “In-111, Y-90 Radiolabeled Peptides for Targeting Prostate Cancer.” J. Nucl. Med., 2001, 42(5), 274P, Suppl. S.

25. Hoffman, T.J.; Smith, C.J.; Sieckman, G.L.; Owen, N.K.; and Volkert, W.A. “Design, Synthesis, and Biological Evaluation of Novel Gastrin Releasing Peptide Receptor Targeting Radiopharmaceuticals.” Abstracts of Papers of the American Chemical Society 220, 2000, U546, Part 1.

26. Hoffman, T.J.; Smith, C.J.; Simpson, C.D.; Sieckman, G.L.; Higginbotham, C.; Jimenez, H.; Eshima, D.; Thornback, J.R.; and Volkert, W.A. “Optimizing Pharmacokinetics of Tc-99m-GRP Receptor Targeting Peptides Using Multi-Amino Acid Linking Groups.” J. Nucl. Med., 2000, 41(5), 228P, Suppl. S.

27. Li, W.P.; Smith, C.J.; Cutler, C.S.; Ketring, A.R.; and Jurisson, S.S. “Development of Receptor-based Radiopharmaceuticals Using Carrier-Free Promethium-149: Syntheses, In Vitro Stability Studies, and In Vivo Biodistribution Studies of DTPA, DOTA, and DTPA-Octreotide Complexes.” J. Nucl. Med., 2000, 41(5), 246P, Suppl. S.

28. Hoffman, T.J.; Simpson, S.D.; Smith, C.J.; Simmons, J.; Sieckman, G.L.; Higginbotham, C.; Eshima, D.; Volkert, W.; and Thornback, J.R. “Accumulation and Retention of Tc-99m RP591 by GRP Receptor Expressing Tumours in SCID Mice.” European Journal of Nuclear Medicine, 1999, 26(9), 1156.

29. Hoffman, T.J.; Simpson, S.D.; Smith, C.J.; Simmons, J.; Sieckman, G.L.; Higginbotham, C.; Eshima, D.; Volkert, W.; and Thornback, J.R. “Accumulation and Retention of Tc-99m RP527 by GRP Receptor Expressing Tumours in SCID Mice.” J. Nucl. Med., 1999, 40(5), 104P, Suppl. S.

30. Smith, C.J.; Hoffman, T.J.; Higginbotham, C.; Wong, E.; Eshima, D.; Thornback, J.; and Volkert, W.A. “Evaluation of a Novel N32 Chelation System for the Preparation of Tc-99m and Re-188 Labeled Biomolecules.” J. Nucl. Med., 1998, 39(5), 215P, Suppl. S.

31. Schibli, R.; Karra, S.R.; Gali, H.; Katti, K.V.; Higginbotham, C.; Smith, C.J.; Hoffman, T.J.; and Volkert, W.A. “ Conjugation of Small Biomolecules and Peptides with Novel Water-Soluble Dithio-Bishyrdroxymethylbisphosphine Ligands.” Abstracts of Papers of the American Chemical Society 215, 1998, U947, Part 1.

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32. Smith, C.J.; Katti, K.V.; and Volkert, W.A. “Synthesis and Coordination Chemistry of New Water-Soluble Bisphosphines.” Abstracts of Papers of the American Chemical Society 212, 1996, 421-INOR, Part 1.

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List of Presentations (Presenting Author Underlined)

Presentations at Nationally- and Internationally-held Conferences:

1. Jiang, Z.; Bandari, R.P.; Stott Reynolds, T.; Rold, T.L.; Hoffman, T.J.; Szczodroski, A.F.; and Smith, C.J. “Synthesis, In Vitro, and In Vivo Evaluation of [DUPA-6-Ahx-Lys-(64Cu-NODAGA)-5-Ava-BBN(7-14)NH2]: a Novel Bivalent Targeting Vector Radiopharmaceutical for Potential PET Imaging of Human Prostate Cancer.” 2014 Midwest Regional Meeting of the American Chemical Society, Columbia, MO, November 2014.

2. Schehr, R.; Stott Reynolds, T.; and Smith C.J. “Characterization of RGD-Glu(90Y-DOTA)-6-Ahx-RM2 for Targeting Prostate Cancer.” Merial-NIH Veterinary Scholars Symposium, Cornell University College of Veterinary Medicine, Ithaca, NY, August 2014.

3. Bandari, R.P.; Stott Reynolds, T.; Jiang, Z.; and Smith C.J. “Novel, Multivalent Tracers Targeting Prostate Cancer Biomarkers.” The 7th International Symposium on Technetium and Other Radiometals in Chemistry and Medicine, Bressanone, Italy, September 2014.

4. Cai, Q.; Besch-Williford, C.; Yu, P.; Smith, C.J.; Hoffman, T.J.; and Ma, L. In Vivo Near-Infrared Fluorescence Imaging of Primary and Metastatic Prostate Cancer.” The Society of Nuclear Medicine 59th Annual Meeting, Miami, Florida, June 2012.

5. Faintuch, B.L.; Oliveira, E.A.; Nunez, E.G.F.; Moro, A.M.; and Smith, C.J. “Tumor Targeting with Radiolabeled Peptides Containing the NGR (Asparagine-Glycine-Arginine) Motif.” EANM’11-Annual Congress of the European Association of Nuclear Medicine, Birmingham, UK, October 17, 2011.

6. Cai, Q.; Sieckman, G.; Smith, J.; Hoffman, T.; Yu, P.; and Ma, L. “Quantitative Detection of Circulating Cancer Cells in Mouse Blood Using Fluorescence-labeled Bombesin.” The 2011 World Molecular Imaging Congress, San Diego, CA, September 2011.

7. Shukla, R.; Zambre, A.; Chandra, N.; Kan, P.; Engelbrecht, H.; Cutler, C.S.; Lever, J.R.; Smith, C.J.; Caldwell, C.W.; Katti, K.; Upendran, A.; Kannan, R.; and Katti, K.V. “Clinical Translation of Radioactive Gold Nanoparticle-based Nanoceutical (EGCG-198AuNP) for Prostate Tumor Therapy.” The 19th International Symposium on Radiopharmaceutical Sciences, Amsterdam, the Netherlands, September 2011.

8. McLaughlin, M.; Chanda, N.; Lever, J.R.; Smith, C.J.; Kannan, R.; Katti, K.; Katti, K.V.; and Cutler, C.S. “Evaluation of Receptor Affinity of Au-198-Starch-Nanoparticles Conjugated to Bombesin.” The 18th International Symposium on Radiopharmaceutical Sciences, Amsterdam, the Netherlands, September 2011.

9. Jackson, A.B.; Nanda, P.K.; Sieckman, G.L.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “A comparison of Monomeric, Multimeric, and Bivalent Site-directed 64Cu-peptide Conjugates for Molecular Imaging of Human Cancers.” The 18th International

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Symposium on Radiopharmaceutical Sciences, Amsterdam, the Netherlands, September 2011.

10. Laverman, P.; Dijkgraaf, I.; McBride, W.J.; D’Souza, C.A.; Eek, A.; Smith, C.J.; Sharkey, R.M.; Oyen, W.J.G.; Goldenberg, D.M.; and Boerman, O.C. “Improvement of Al18F-labeling of Peptides and In Vivo Characterization.” The 18 th International Symposium on Radiopharmaceutical Sciences, Amsterdam, the Netherlands, September 2011.

11. Ma, L.; Smith, J.; Cai, Q.; Nanda, P.; Price, S.; and Zhai, H. “Multimodal Imaging for Early Detection of Prostate Cancer.” Proceedings of Innovated Minds in Prostate Cancer Today (IMPaCT), Orlando, FL, March 2011.

12. Ma, L.; Cai., Q.; Nanda, P.K.; Smith, C.J.; Hoffman, T.J.; Yu, P.; and Volkert, W.A. “MRI and Near-infrared Fluorescence Imaging of Gastrin Releasing Peptide Receptor-expressing Tumors.” The Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, June 2011.

13. Dijkgraaf, I.; Franssen, G.; McBride, W.; D’Souza, C.; Smith, C.J.; Goldenberg, D.; Oyen, W.; and Boerman, O. “Targeting GRPR-expressing Tumors with an 18F-labeled Bombesin Analogue.” The Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, June 2011.

14. Jackson, A.B.; Nanda, P.K.; Sieckman, G.L.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “Site-directed Molecular Imaging of Human Cancers via Multimeric Conjugates.” The Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, June 2011.

15. Wienhoff, B.E.; Shaffer, S.M.; Lane, S.R.; Jurisson, S.S.; Brechbiel, M.W.; Nanda, P.K.; and Smith, C.J. “Site-directed Radiopharmaceutical Development for Treatment of Prostate Cancer.” The Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, June 2011.

16. Oliveira, E.A.; Faintuch, B.L.; Fernandez, E.G.; Santos, R.P.S.; Silva, N.G.; Targino, R.; Moro, A.M.; and Smith, C.J. “99mTc-MAG3-PEG8-c(RGDYK) Uptake in Melanoma Tumor.” The Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, June 2011.

17. Nanda, P.K.; Pandey, U.; Bottenus, B.N.; Lane, S.R.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith C.J. “Comparative Study of 64Cu and 67Ga-Bombesin Antagonists as Potential Agents for Prostate Cancer Imaging.” 240 th National Meeting of the American Chemical Society, Boston, MA, August, 2010.

18. Kan, P.; Engelbrecht, H.; Shukla, P.R.; Lever, J.R.; Smith, C.J.; Kannan, R.; Katti, K.V.; Jurisson, S.S.; Cutler, C.S. “In Vivo Evaluation of EGCG Stabilized Gold-198 Nanoparticles in Prostate Cancer Bearing Mice.” The Society of Nuclear Medicine 57th Annual Meeting, Salt Lake City, Utah, June 2010.

19. Esteves, T.; Marques, F.; Rino, J.; Smith, C.J.; and Santos, I.; “Trifunctional Tricarbonyl Complexes for Cell-Specific and Nuclear Targeting.” The 7th International

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Symposium on Technetium and Other Radiometals in Chemistry and Medicine, Bressanone, Italy, September 2010.

20. Faintuch, B.L.; Fernandez, E.; Teodoro, R.; Wiecek, D.; Agarbuio, A.; Moro, A.; and Smith, C.J. “99mTc-SAMA-GGG-Ahx-BBN for GRP Receptor Targeting.” The Society of Nuclear Medicine 57th Annual Meeting, Salt Lake City, Utah, June 2010.

21. Smith C.J.; Nanda, P.K.; Lane, S.; Sieckman, G.L.; Hoffman, T.J.; and Rold, T.; “A Comparative Study of 64Cu-NO2A-Bombesin Antagonist and Agonist Ligands.” The 7th International Symposium on Technetium and Other Radiometals in Chemistry and Medicine, Bressanone, Italy, September 2010.

22. Nanda, P.K.; Pandey, U.; Rold, T.L.; Sieckman, G.L.; Figueroa, S.D.; Ma, L.; Hoffman, T.; and Smith, C.J. “In Vitro and In Vivo Evaluation of 64Cu-NO2A-X-9BBN Antagonists as Potential Agents for Prostate Cancer Imaging.” The Society of Nuclear Medicine 57th Annual Meeting, Salt Lake City, Utah, June 2010.

23. Manuel, C.A.; Bottenus, B.N.; Schreiber, K.L.; Sieckman, G.L.; Prasanphanich, A.F.; Smith, C.J.; and Hoffman, T.J. “Preferential Cell Cycle Expression of the Bombesin Receptor (BB2r) in Prostate Cancer Cells.” 101st Annual Meeting of the American Association for Cancer Research, Washington, D.C., April, 2010.

24. Nanda, P.K.; and Smith, C.J. “A New Series of Site Specific 64Cu-Bombesin

Conjugates as Human Cancer Cell Imaging Agents.” 238th National Meeting of the American Chemical Society, Washington, D.C., August, 2009.

25. Wiecek, D.; Faintuch, B.; Teodoro, R.; Fernandez, E.; and Smith, C. “Radiolabeling and Biodistribution Studies of the New Angiogenesis Tracer Cyclic ASn-Gly-Arg (NGR).” The Society of Nuclear Medicine 56th Annual Meeting, Toronto, Canada, June 2009.

26. Karacay, H.; McBride, W.; Sharkey, R.; Cardillo, T.; Smith, C.; and Goldenberg, D. “18F Labeling of a Peptide for PET Imaging of Receptor-expressing Tumors.” The Society of Nuclear Medicine 56th Annual Meeting, Toronto, Canada, June 2009.

27. Zhai, H.; Nanda, P.; Smith, J.; Brown, A.; Lin, H.; Yu, P.; Sieckman, G.; Hoffman, T.; Sethi, Y.; and Ma, L. “Multifunctional Contrast Agents for Prostate Cancer Molecular Imaging.” The 2009 World Molecular Imaging Congress, Montreal, Quebec, September 2009.

28. Lane, S.; Nanda, P.; Prasanphanich, A.; Sieckman, G.; Rold, T.; Ma, L.; Figueroa, S.; Sublett, S.; Hoffman, T.; and Smith C. “In Vitro and In Vivo Evaluation of [64Cu-NO2A-(X)-BBN(7-14)NH2] Radiopharmaceuticals for Potential PET Imaging of Human Prostate Cancer.” The 18th International Symposium on Radiopharmaceutical Sciences, Edmonton, Alberta, July 2009.

29. Kan, P.; Engelbrecht, H.P.; Watkinson, L.D.; Carmack, T.L.; Lever, J.R.; Smith, C.J.; Kannan, K.V.; Katti, K.V.; Jurisson, S.S.; and Cutler, C.S. “Evaluation of Gum Arabic Stabilized Gold-198 Nanoparticles in Prostate Cancer Bearing Mice.” The 18th

International Symposium on Radiopharmaceutical Sciences, Edmonton, Alberta, July 2009.

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30. Retzloff, L.B.; Smith, C.; Hoffman, T.; Rold, T.; Sieckman, G.; and Heinzke, L. “Breast Cancer Imaging.” The 7th Annual Meeting of the Society for Molecular Imaging, Nice, France, September 2008.

31. Boote, E.; Smith, J.; Lever, J.; Watkinson, L.; Carmack, T.; Robertson, D.; Katti, K.; Kannan, R.; and Katti, K. “Gold Nanoparticles as a Computed Tomography Contrast Agent in SCID Mice with PC-3 Xenografts.” The 7 th Annual Meeting of the Society for Molecular Imaging, Nice, France, September 2008.

32. Lane, S.R.; Prasanphanich, A.F.; Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; Jurisson, S.S.; and Smith, C.J. “Development of Copper-64 Bombesin Conjugates for Use as Prostate Cancer Imaging Agents.” The 7 th Annual Meeting of the Society for Molecular Imaging, Nice, France, September 2008.

33. Volkert, W.A.; Hoffman, T.J.; Quinn, T.P.; and Smith, J. “Radiometallated SPECT Cancer Specific Imaging Radiopharmaceuticals.” American Nuclear Society: 2008 Annual Meeting, Anaheim, CA, June 8-12, 2008.

34. Lane, S.R.; Jurisson, S.S.; Prasanphanich, A.F.; Nanda, P.K.; and Smith, C.J. “Copper-64 Bombesin Conjugates for Prostate Cancer Imaging.” Division of Nuclear Chemistry and Technology Graduate Student Symposium: The 236th National Meeting of the American Chemical Society, Philadelphia, PA, August 17-21, 2008.

35. Kan, P.; Rahing, V.N.; Watkinson, L.D.; Carmack, T.L.: Lever, J.; Smith, C.J.; Loyalka, S.; Katti, K.V.; Cutler, C.S.; and Jurisson, S.S. “The Potential of Gum Arabic Stabilized Au-198 Nanoparticles (GA-AuNP) as a Radiotherapeutic Agent for Prostate Cancer.” 99th Annual Meeting of the American Association for Cancer Research, Los Angeles, CA, April, 2008.

36. Ma, L.; Brown, A.; Kujala, N.; Smith, C.J.; Figueroa, S.D.; Yu, P.; Hoffman, T.J.; and Volkert, W.A. “Functional Apparent Diffusion Mapping the Uptake of Tumor-Targeting Bombesin Probes in Human Breast and Prostate Cancer Xenografts.” The 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, Toronto, Canada, May 2008.

37. Ma, L.; Figueroa, S.D.; Brown, A.; Smith, C.J.; Garrison, J.; Yu, P.; Hoffman, T.J.; and Volkert, W.A. “Correlation Between In Vivo Uptake of Tumor-Targeting Bombesin Probes and Apparent Diffusion Coefficient Map in Human Cancer Xenografts.” The 6th Annual Meeting of the Society for Molecular Imaging, Providence, RI, August/September 2007.

38. Prasanphanich, A.P.; Nanda, P.K.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “A

New Series of Stable, 64Cu Labeled, Site-Directed Radiopharmaceuticals for Use as PET Imaging Agents.” The Society of Nuclear Medicine 54th Annual Meeting, Washington, D.C., June 2007.

39. Prasanphanich, A.P.; Nanda, P.K.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “Evaluation of a New Series of Copper-64-NOTA-Bombesin Targeted Radiopharmaceuticals with PET Imaging Potential.” 17th International Symposium on Radiopharmaceutical Sciences, Aachen, Germany, May 2007.

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40. Ma, L.; Smith, C.J.; and Yu, P. “Optical/MRI Multimodality Molecular Imaging.” 2007 Meeting of the American Physics Society: New Frontiers in Imaging III, Denver, Colorado, March 2007.

41. Balasubramanian, S.; Pacheco, D.; Kujala, N.G.; Yu, P.; Ma, L.; and Smith C.J. “Instrumentation and Calibration Method of Fluoresence Molecular Tomography for Multimodality Fusion Imaging.” The 5th Annual Meeting of the Society for Molecular Imaging, Big Island, Hawaii, August/September 2006.

42. Pacheco, D.; Kujala, N.G.; Balasubramanian, S.; Ma, L.; Smith, C.J.; and Yu, P. “Development of Simulated Breast Phantoms for Multimodality Imaging.” The 5 th

Annual Meeting of the Society for Molecular Imaging, Big Island, Hawaii, August/September 2006.

43. Ma, L.; Smith, C.J.; Sieckman, G.; Rold, T.L.; Hoffman, T.J.; Volkert, W.A.; and Yu, P. “Bombesin Receptor (BB2r) Targeted Fluoresence Imaging Probes.” The 5th

Annual Meeting of the Society for Molecular Imaging, Big Island, Hawaii, August/September 2006.

44. Figueroa, S.D.; Winkelmann, C.; Rold, T.; Garrison, J.; Smith, C.J.; Volkert, W.A.; and Hoffman, T.J. “Micro-SPECT Quantification and Molecular Imaging of GRP Expressing Tumors.” The 5th Annual Meeting of the Society for Molecular Imaging, Big Island, Hawaii, August/September 2006.

45. Kunstler, J.-U.; Veerendra, B.; Sieckman, G.L.; Smith, C.J.; and Pietzsch, H.-J. “Novel Approaches for 99mTc Labeling of Peptides: Organometallic Tc(III) Complexes for Bombesin Labeling.” The 7th International Symposium on Technetium in Chemistry and Nuclear Medicine, Bressanone, Italy, September 2006.

46. Figueroa, S.D.; Ma, L.; Rold, T.L.; Sieckman, G.L.; Smith, C.J.; Garrison, J.C.; Volkert, W.A.; and Hoffman, T.J. “Oncology Molecular Imaging of GRP+ Receptor Expressing Breast Tumors with Siemens Micro-SPECT/CT Technology.” The 92nd

Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, IL, November 2006.

47. Rold, T.L.; Garrison, J.C.; Sieckman, G.L.; Carter, S.N.; Bell, N.R.; Smith, C.J.; Cutler, C.S.; Ketring, A.R.; and Hoffman, T.J. “Targeting BB2 Receptor Expression in Prostate Cancer Using Promethium-149 Labeled Peptides.” 96th Annual Meeting of the American Association for Cancer Research, Washington, D.C., April, 2006.

48. Hoffman, T.J.; Rold, T.L.; Sieckman, G.L.; Smith, C.J.; Volkert, W.A.; and Perry, M.C. “BB2 Receptor Targeted Radiotherapy Combined with Chemotherapy for the Treatment of Pre-clinical Xenograft Models of Breast Cancer.” 96th Annual Meeting of the American Association for Cancer Research, Washington, D.C., April, 2006.

49. Veerendra, B; Lane, S.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.; Retzloff, L.; Prasanphanich, A.; Jurisson, S.S.; and Smith C.J. “99mTc-(CO)3-DTMA (DTMA = Diethylenetriamineacetic Acid) Conjugates of Bombesin: A Novel Series of Peptide Conjugates Having Very High Affinity for the GRP Receptor Subtype 2.” The 7th

International Symposium on Technetium in Chemistry and Nuclear Medicine, Bressanone, Italy, September 2006.

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50. Daibes Figueroa, S.; Winkelmann, C.T.; Rold, T.L.; Sieckman, G.L.; Smith, C.J.; Garrison, J.C.; Ma, L.; Volkert, W.A.; and Hoffman, T.J. “TLD-100 Measurement and Assessment of Internal Mouse Dosimetry During Micro-CT Analysis.” The 48 th

Annual Meeting of The American Association of Physicists in Medicine, Orlando, Florida, July 2006.

51. Decristoforo, C.; Haubner, R.; Rey, A.; Kuenstler, J.U.; Pietzsch, H.J.; Correia, J.D.G.; Santos, I.; Smith, C.J.; Faintuch, B.; Hernandez-Gonzales, I.; and Rupprich, M. “Comparison of In Vitro and In Vivo Properties of 99mTc-RGD Peptides for Targeting Tumour Angiogenesis Labeled Using Different, Novel, 99mTc-Cores.” The European Symposium of Radiopharmacy and Radiopharmaceuticals, Lucca, Italy, March 2006.

52. Figueroa, S.D.; Winkelmann, C.T.; Rold, T.L.; Sieckman, G.L.; Smith, C.J.; Garrison, J.C.; Ma, L.; Volkert, W.A.; and Hoffman, T.J. “Molecular Imaging Performance and Applications of the BIC Small Animal SPECT/CT Unit.” Academy of Molecular Imaging, Orlando, Florida, March 2006.

53. Faintuch, B.L.; Stoianov, V.; Santos, R.L.S.R.; Duatti, A.; and Smith C.J. “Labeling of Bombesin Analogue by Asymmetrical Technetium-99m Nitrido Core.” International Symposium on Trends in Radiopharmaceuticals, Vienna, Austria, November 2005.

54. Faintuch, B.L.; Ayrosa, A.M.I.B; Smith, C.J.; and Castanheira, C.E. “Characterization of Lyophilized Parameters of a New Radiopharmaceutical Kit for Prostate Tumor Diagnostic.” International Society of Lyophilization-Freeze Drying, Inc. Sao Paulo, Brazil, October 2005.

55. Smith, C.J.; Alves, S.; Santos, I.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.; Retzloff, L.; McCrate, J.; and Prasanphanich, A. “Technetium-I Pyrazolyl Bombesin Conjugates: A Concise In Vitro/In Vivo Study.” 16th International Symposium on Radiopharmaceutical Chemistry, Iowa City, IA, June 2005.

56. Ehrhardt, G.; Moustapha, M.; Smith, C.J.; Szajek, L.; Eckelman, W.; and Jurisson, S. “Preparation of Cyclotron Re-186 and Comparison with Reactor Re-186 and Generator Re-188 for the Labeling of Bombesin.” 16th International Symposium on Radiopharmaceutical Chemistry, Iowa City, IA, June 2005.

57. Ma, L.; Smith, C.J.; Sieckman, G.L.; Volkert, W.A.; and Hoffman, T.J. “Structural Characterization of DOTA-8-AOC-Bombesin(7-14)NH2 Analogue Using Nuclear Magnetic Resonance Spectroscopy.” 16th International Symposium on Radiopharmaceutical Chemistry, Iowa City, IA, June 2005.

58. Hoffman, T.J.; Rold, T.L.; Bell, N.R.; Sieckman, G.L.; and Smith, C.J. “Evaluating Combination Lu-177 GRP Receptor Targeted Radiotherapy and Chemotherapy in Breast Cancer Xenograft Models.” The Society of Nuclear Medicine 52nd Annual Meeting, Toronto, CA, June 2005.

59. Johnson, C.V.; Shelton, T.D.; Greeley, M.M.; Smith, C.J.; and Hoffman, T.J. “GRP

Receptor-targeted Radiotherapy and Combined Chemotherapy in Androgen

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Independent Prostate Cancer Xenografted Mice.” The Society of Nuclear Medicine 51st Annual Meeting, Philadelphia, PA, USA, June 2004.

60. Johnson, C.V.; Shelton, T.; Smith, C.J.; Greeley, M.; Perry, M.C.; and Hoffman, T.J. “Synergism of Combined Chemotherapy/Radiotherapy in PC-3 Prostate Tumor Xenografted Mice.” 95th Annual Meeting of the American Association for Cancer Research, Orlando, Florida, March, 2004.

61. Greeley, M.; Smith, C.J.; Sieckman, G.L.; Shelton, T.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Evaluation of In-111 and Tc-99m Labeled Peptides Targeting Subtypes of the Bombesin (BBN) Receptor.” 38th Midwest Regional Meeting of the American Chemical Society, Columbia, MO, November 7, 2003.

62. Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Atkinson, L.A.; Volkert, W.A.; and Hoffman, T.J. “Design and Development of Tc-99m-Carbonyl-Bombesin Analogs: A Structure Activity Relationship Study.” The Society of Nuclear Medicine 50th Annual Meeting, New Orleans, LA, USA, June 23, 2003.

63. Hoffman, T.J.; Smith, C.J.; Owen, N.K.; Sieckman, G.L.; Foster, B.N.; Mazuru, D.; and Volkert, W.A. “Lu-177 Radiolabeled Peptides for Targeted Radiotherapy of Androgen Independent Prostate Cancer.” 94th Annual Meeting of the American Association for Cancer Research, Toronto, Ontario, Canada, April, 2003.

64. Papagiannopoulou, D.; Kannan, R.; Katti, K.; Smith, C.J.; Hoffman, T.; Owens, N.; Greeley, M.; and Jurisson, S.S. “Synthesis and Biological Evaluation of Novel 99mTc Tricarbonyl Complexes with Amine Ligands.” The Society of Nuclear Medicine 49th

Annual Meeting, Los Angeles, CA, USA, June, 2002.

65. Smith , C.J. ; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.L.; Kannan, R.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of [99mTc(H2O)(CO)3-Dpr-(X)-Bombesin(7-14)NH2], a New Family of GRP-receptor Targeting Radiopharmaceuticals.” Sixth International Symposium on Technetium in Chemistry and Nuclear Medicine, Bressanone, Italy, September, 2002.

66. Hoffman, T.J.; Smith, C.J.; Gali, H.; Owen, N.K.; Sieckman, G.L.;Foster, B.; Mazuru, D.; and Volkert, W.A. “Preclinical Evaluation of Y-90 and Lu-177 Radiolabeled Peptides for In Vivo Targeted Radiotherapy of Prostate Cancer.” 18th UICC (International Union Against Cancer) International Cancer Congress, Oslo, Norway, July, 2002.

67. Gali, H.; Smith, C.J.; Hoffman, T.J.; Sieckman, G.L.; Hayes, D.L.; Owen, N.K.; and Volkert, W.A. “Influence of the Radiometal on the In Vivo Pharmacokinetic Properties of a Radiometal-labeled DOTA-conjugated Peptide.” 222th National Meeting of the American Chemical Society, Chicago, IL, August, 2001.

68. Smith , C.J. ; Hoffman, T.J.; Hayes, D.L.; Owen, N.K.; Sieckman, G.L.; and Volkert, W.A. “Detailed Radiochemical Investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH2: A New Gastrin Releasing Peptide Receptor (GRPr) Targeting Radiopharmaceutical.” 14th International Symposium on Radiopharmaceutical Chemistry, Interlaken, Switzerland, June, 2001.

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69. Hoffman, T.J.; Smith, C.J.; Gali, H.; Owen, N.K.; Sieckman, G.L.; Hayes, D.L.; and Volkert, W.A. “Development of a Diagnostic Radiopharmaceutical for Visualization of Primary and Metastatic Breast Cancer.” The Society of Nuclear Medicine 48 th

Annual Meeting, Toronto, Canada, June, 2001.

70. Hoffman, T.J.; Smith, C.J.; Gali, H.; Owen, N.K.; Sieckman, G.L.; Hayes, D.L.; and Volkert, W.A. “111In/90Y Radiolabeled Peptides for Targeting Prostate Cancer: A Matched Pair Gastrin Releasing Peptide (GRP) Receptor Localizing Radiopharmaceutical.” The Society of Nuclear Medicine 48th Annual Meeting, Toronto, Canada, June, 2001.

71. Hoffman, T.J.; Smith, C.J.; Gali, H.; Owen, N.K.; Sieckman, G.L.; and Volkert, W.A. “In Vitro and In Vivo Evaluation of 111In/90Y Radiolabeled Peptides for Specific Targeting of Tumors Expressing Gastrin Releasing Peptide (GRP) Receptors.” 92nd

Annual Meeting of the American Association for Cancer Research, New Orleans, LA, March, 2001.

72. Hoffman, T.J.; Smith, C.J.; Sieckman, G.L.; Owen, N.K.; and Volkert, W.A. “Design, Synthesis, and Biological Evaluation of Novel Gastrin Releasing Peptide Receptor Targeting Radiopharmaceuticals.” 220th National Meeting of the American Chemical Society, Washington, D.C., August, 2000.

73. Volkert, W.A.; Gali, H.; Hoffman, T.J.; Owen, N.K.; Sieckman, G.L.; and Smith, C.J. “In-111 and Y-90 Labeled GRP Analogs: A Structure Activity Relationship.” The International Chemical Congress of Pacific Basin Societies, Pacifachem 2000, Honolulu, HA, December, 2000.

74. Jurisson, S.S.; Li, W.P.; Cutler, C.S.; Smith, C.J.; Owen, N.K.; and Hoffman, T.J. “DTPA-Octreotide Complexes with the NCA Radiolanthanides (Pm-149, Ho-166, Lu-177).” The International Chemical Congress of Pacific Basin Societies, Pacifachem 2000, Honolulu, HA, December, 2000.

75. Li, W.P.; Smith, C.J.; Cutler, C.S.; Jurisson, S.; and Ketring, A.R. “Development of Receptor-Based Radiopharmaceuticals Using Carrier-Free Promethium-149: Syntheses, In Vitro Stability Studies, and In Vivo Biodistribution Studies of DTPA, DOTA, and DTPA-Octreotide Complexes.” The Society of Nuclear Medicine 47th

Annual Meeting, St. Louis, MO, June 6, 2000.

76. Hoffman, T.J.; Smith, C.J.; Simpson, S.D.; Sieckman, G.L.; Higginbotham, C.; Jimenez, H.; Eshima, D.; Thornback, J.R.; and Volkert, W.A. “Optimizing Pharmacokinetics of Tc-99m-GRP Receptor Targeting Peptides Using Multi-Amino-Acid Linkers.” The Society of Nuclear Medicine 47th Annual Meeting, St. Louis, MO, June 5, 2000.

77. Hoffman, T.J.; Smith, C.J.; Simpson, S.D.; Sieckman, G.L.; Higginbotham, C.; Jimenez, H.; Eshima, D.; Thornback, J.R.; and Volkert, W.A. “Targeting Gastrin Releasing Peptide Receptor (GRP-R) Expression in Prostate and Pancreatic Cancer Using Radiolabeled GRP Agonist Peptide Vectors.” The 91st Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 3, 2000.

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78. Hoffman, T.J.; Simpson, S.D.; Smith, C.J.; Sieckman, G.L.; Higginbotham, C.; Eshima, D.; Volkert, W.; and Thornback, J.R. “Accumulation and Retention of 99mTc-RP591 by GRP Receptor Expressing Tumors in SCID Mice.” Congress of the European Association of Nuclear Medicine, Barcelona, Spain, September, 1999.

79. Hoffman, T.J.; Simpson, S.D.; Smith, C.J.; Simmons, J.; Sieckman, G.L.; Higginbotham, C.; Eshima, D.; Volkert, W.; and Thornback, J.R. “Accumulation and Retention of Tc-99m RP527 By GRP Receptor Expressing Tumors in Scid Mice.” The Society of Nuclear Medicine 46th Annual Meeting, Los Angeles, CA, June 9, 1999.

80. Ehrhardt, G.; Cutler, C.; Smith, C.J.; Li, W.; Ma, D; and Evans-Blumer, M. “Radiolanthanides: Production and Uses in Cancer Therapy.” High Country Nuclear Medicine Conference, Vail, CO, February 28, 1999.

81. Katti, K.V.; Berning, D.E.; Smith, C.J.; and Gali, H. “Construction of Water-Soluble Phosphines. New Advances in Aqueous Organometallic Chemistry.” XIVth International Conference on Phosphorus Chemistry, Cincinnati, OH, July 14, 1998.

82. Smith, C.J.; Higginbotham, C.; Katti, K.V.; and Volkert, W.A. “Rhodium-105 Complexes of Polydentate, Aqueous-Soluble, Phosphine Ligands: New Radiochemical Developments Towards Radioimmunotherapy.” XIVth International Conference on Phosphorus Chemistry, Cincinnati, OH, July 15, 1998.

83. Smith, C.J.; Hoffman, T.J.; Higginbotham, C.; Wong, E.; Eshima, D.; Thornback, J.; and Volkert, W.A. “Evaluation of a Novel N3S Chelation System for the Preparation of Tc-99m and Re-188 Labeled Biomolecules.” The Society of Nuclear Medicine 45th Annual Meeting, Toronto, Canada, June 10, 1998.

84. Schibli, R.; Karra, S.R.; Gali, H.; Katti, K.V.; Higginbotham, C.; Smith, C.J.; Hoffman, T.J.; and Volkert, W.A. “Conjugation of Small Biomolecules and Peptides with a Novel Water-Soluble Dithio-Bishydroxymethylbisphosphine Ligand.” 215th National Meeting of the American Chemical Society, Dallas, TX, March 31, 1998.

85. Smith, C.J.; Katti, K.V.; Higginbotham, C.; Volkert, W.A.; and Ketring, A.R. “In Vivo Studies of Tc-99m Complexes Derived From New Water-Soluble Dithio(hydroxymethyl)bisphosphines (P2S2).” 12th International Symposium on Radiopharmaceutical Chemistry, Uppsula, Sweden, June 17, 1997.

86. Katti, K.V.; Smith, C.J.; Berning, D.E.; Reddy, V.S.; Karra, S.R.; and Volkert, W.A. “Synthesis and Chemical Characterization of 99mTc and Re Complexes with Multidentate (Hydroxymethyl)phosphine (HMP) Ligands.” 10th International Symposium on Radiopharmacology, Milan, Italy, May 19, 1997.

87. Smith, C.J.; Katti, K.V.; and Volkert, W.A. “Synthesis and Structural Characterization of Water-Soluble Dithio-Bisphosphine Rhenium (V) Complexes.” 29 th Central Regional Meeting of the American Chemical Society, Midland, MI, May 29, 1997.

88. Karra, S. R.; Katti, K. V.; Smith, C. J.; Reddy, V. S.; and Volkert, W. A. “Development of Water-Soluble Diamide-Diphosphine Ligands.” 212th National Meeting of the American Chemical Society, Orlando, FL, August 27, 1996.

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89. Smith, C. J.; Katti, K. V.; and Volkert, W. A. “Synthesis and Coordination Chemistry of New Water-Soluble Bisphosphines.” 212th National Meeting of the American Chemical Society, Orlando, FL, August 27, 1996.

90. Katti, K.V.; Reddy, S.V.; Singh, P.R.; Berning, D.E.; Smith, C. J.; Volkert, W.A.; and Ketring, A.R. “New Directions in the Development of Water-Soluble Phosphines and Transition Metal Compounds.” XIIIth International Conference on Phosphorus Chemistry-ICPC, Jerusalem, Israel, July, 1995.

91. Smith, C. J.; Conkright, T.L.; and Jurisson, S.S. “Radiosynthesis and Characterization of a 99mTechnetium - - Melanotropin Stimulating Hormone Analogue: A Potential Radiolabel for the -Melanocyte.” 29th Midwest Regional Meeting of the American Chemical Society, Kansas City, MO, November 3, 1994.

List of Invited Lectures or Presentations:

1. Smith, C.J.; Nanda, P.K.; Ma, L.; Stott Reynolds, T.; Hoffman, T.J.; Bernskoetter, N.E. and Jiang, Z. “Molecular Imaging Probes Based Upon Bombesin Peptide.” The 13th International Congress on Amino Acids, Galveston, Texas, October 5, 2013.

2. Smith, C.J. “Molecular Probes for Diagnosis and Therapy of Human Disease.” University of Missouri Department of Chemistry Colloquium Seminar Series, Columbia, Missouri, March 3, 2012.

3. Smith, C.J. “Imaging Probes for Specifc Targeting of Human Cancer Cells.” University of Missouri Radiopharmaceutical Sciences Institute Seminar Series, Columbia, Missouri, February 21, 2012.

4. Jackson, A.B.; Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith, C.J. “Peptide-based 64Cu Probes for Prostate Cancer Imaging.” Lab Week 2011 Educational Seminar, Erie, PA, April 28, 2011.

5. Jackson, A.B.; Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith, C.J. “Peptide-based Probes for Prostate Cancer Imaging.” University of the Sciences, Philadelphia, PA, April 18, 2011.

6. Smith, C.J. “Metallated Peptide Conjugates for Molecular Imaging of Human Cancers.” Benedictine College, Atchison, KS, December 3, 2010.

7. Smith, C.J. “Metallated Peptide Conjugates for Specific Targeting of Human Cancers.” University of Oklahoma College of Pharmacy, Oklahoma City, OK, October 19, 2010.

8. Smith, C.J. “E Pluribus Unum.” Risco High School Senior Graduating Class of 2009 Commencement Exercise, Risco, Missouri, May 17, 2009.

9. Smith, C.J. “Metallated Peptide Conjugates for Specific Targeting of Human Cancers.” University of Missouri Department of Chemistry Dynamite Seminar Series, Columbia, Missouri, February 10, 2009.

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10. Lewis, M.R.; Prasanphanich, A.F.; Retzloff, L.; Lane, S.R.; Nanda, P.R.; Sieckman, G.L.; Rold, T.L.; Ma, L.; Figueroa, S.D.; Sublett, S.V.; Hoffman, T.J.; and Smith, C.J. “In Vitro and In Vivo Evaluation of [64Cu-NOTA-8-Aoc-BBN(7-14)NH2] Radiopharmaceutical for PET Imaging of Human Breast and Prostate Cancer Tumors.” Eighth International Conference of Anticancer Research, Kos, Greece, October 17-22, 2008.

11. Heinzke, L..; Retzloff, L.; Lane, S.; Prasanphanich, A.; Sieckman, G.; Rold, T.; Hoffman, T.; and Smith, C. “99mTc-DPR-SSS-BBN for Diagnosis of Human Cancers.” Undergraduate Research Day at the Capitol, Jefferson City, MO, April 2008.

12. Prasanphanich, A.; Nanda, P.K.; Rold, T.L.; Ma, L.; Hoffman, T.J.; Sieckman, G.L.; Figueroa, S.D.; and Smith, C.J. “Development of Highly Specific Radiopharmaceutical & Molecular Imaging Agents for Diagnosis of Human Cancers.” Council on Undergraduate Research Posters on Capitol Hill, Washington, D.C., April 25, 2007.

13. Prasanphanich, A.P.; and Smith, C.J. “Development of Tumor-targeting Agents for

Diagnosis of Human Cancers.” Undergraduate Research Day at the Capitol, Jefferson City, MO, April 2007.

14. Smith, C.J. “Molecular Imaging of Gastrin Releasing Peptide Receptor Expressing Tumors: The Missouri Experience.” Recent Advances in Molecular Imaging: A Special Symposium of the 232nd National Meeting of the American Chemical Society, San Francisco, CA, September 10-14, 2006.

15. Smith, C.J. “Radiolabeled Tc(III) and Tc(I) Bioconjugates for Targeting Specific Human Cancers.” 3rd Co-ordination Meeting on “Development of 99mTc-based Small Biomolecules Using Novel 99mTc Cores.” The International Atomic Energy Agency, Budapest, Hungary, May 16, 2006.

16. Smith, C.J. “Low-Valent Tc/Re(I) Bioconjugates for Targeting Prostate Cancer”. Saint Louis University, March 3, 2006.

17. Smith, C.J. “Non-traditional Radiolabeling Methods for Production of Technetium-based Conjugates: A Concise In Vitro and In Vivo Study.” Instituto Tecnologico E Nuclear, Savacem/Lisbon, Portugal, November 28, 2005.

18. Smith, C.J. “Advanced Aspects of Tricarbonyl Approaches.” European Cooperation in the Field of Scientific and Technical Research (COST Action B12: Radiotracers for In Vivo Assessment), Lisbon, Portugal, May 22, 2004.

19. Smith, C.J. “Approaches for the Labeling of Peptides with Tc-99m.” Society of Nuclear Medicine 51st Annual Meeting, Philadelphia, PA, USA, June 19, 2004.

20. Smith, C.J. “Radiolabeling of Receptor-Specific Peptides: The Missouri Experience.” 2nd Co-ordination Meeting on “Development of 99mTc-based Small Biomolecules Using Novel 99mTc Cores.” The International Atomic Energy Agency, Vienna, Austria, November 16, 2004.

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21. Smith, C.J. “Radiolabeling Strategies for the Design and Development of Receptor-Specific Radiopharmaceuticals Targeting the GRP Receptor.” 1st Co-ordination Meeting on “Development of 99mTc-based Small Biomolecules Using Novel 99mTc Cores.” The International Atomic Energy Agency, Ferrara, Italy, May 7, 2003.

22. Smith, C.J. “Technetium(I) Labeling of Bombesin.” A Consultant’s Meeting on “Recent Advances in 99mTc Labeling of Small Molecules Using Novel 99mTc Cores.” The International Atomic Energy Agency, Zurich, Switzerland, May 16, 2002.

List of Presentations at the University of Missouri or the Harry S. Truman Memorial Veterans’ Hospital:

1. Xu, H.; Yu, P.; Smith, C.J.; Aro, M.R.; Hoffman, T.; and Ma, L. “Bimodal MRI/Fluorescence Imaaging Contrast Agent Targeting Prostate Cancer.” University of Missouri Health Sciences Research Day, Columbia, MO, November, 2014.

2. Stott Reynolds, T.; Bandari, R.P.; Jiang, Z.; Bernskoetter, N.E.; Etzler, J.; Kirkpatrick, D.L.; Bassuner, K.J.; Rold, T.L.; Sieckman, G.L.; Connors, J.P.; and Smith, C.J. Peptide-based Molecular Imaging Probes.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2014.

3. Bandari, R.P.; Jiang, Z.; Stott Reynolds, T.; Bernskoetter, N.E.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith, C.J. “Synthesis and Biological Evaluation of Copper-64 Radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a Novel Bivalent Targeting Vector Having Affinity for Two Distinct Biomarkers (GRPr/PSMA) of Prostate Cancer.” University of Missouri Health Sciences Research Day, Columbia, MO, November, 2013.

4. Stott Reynolds, T.; Bandari, R.P.; Jiang, Z.; Bernskoetter, N.E.; Etzler, J.; Kirkpatrick, D.L.; Bassuner, K.J.; Rold, T.L.; Sieckman, G.L.; Connors, J.P.; and Smith, C.J. Peptide-based Molecular Imaging Probes.” University of Missouri Health Sciences Research Day, Columbia, MO, November, 2013.

5. Cai, Q-Y.; Yu, P.; Besch-Williford, C.; Smith, C.J.; Sieckman, G.L.; Hoffman, T.J.; and Ma, L. “Near-infrared Fluorescence Imaging of Lymph Node Metastases by Targeting the Gastring Releasing Peptide Receptor.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, May, 2013.

6. Zhai, H.; Nanda, P.; Smith, J.; Lin H.; Yu, P.; Sieckman, G.; Hoffman, T.; Sethi, Y.; and Ma, L. “Multifunctional Optical/MRI Contrast Agents for Prostate Cancer Molecular Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2009.

7. Vaslow, A.; Cai, Q.; Gallazzi, F.; Sieckman, G.; Smith, C.; Hoffman, T.; and Ma, L.; “In Vivo MRI Detection of GRP Receptors Using a High Affinity and Selectivity (Gd(DOTA))8Bombesin[7-14]NH2 Dendron for Targeting Prostate Cancer.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, April, 2012.

8. Vaslow, A.; Cai, Q.; Gallazzi, F.; Sieckman, G.; Smith, C.; Hoffman, T.; and Ma, L.; “In Vivo MRI Detection of GRP Receptors Using a High Affinity and Selectivity

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(Gd(DOTA))8Bombesin[7-14]NH2 Dendron for Targeting Prostate Cancer.” University of Missouri Life Sciences Week, Columbia, MO, April 16-20, 2012.

9. Hoffman, T.J.; Richmond, K.L.; and Smith, C.J. “Cancer Drug Development Center.” Mizzou Advantage, Bond Life Sciences Center, Columbia, MO April 6, 2012.

10. Hoffman, T.J.; Lewis, M.R.; and Smith, C.J. “Molecular Imaging of Cancer: VA Program Project Concept.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, May, 2011.

11. Nanda, P.K.; Jackson, A.B.; Rold, T.L.; Sieckman, G.L.; Szczodroski, A.F.; Hoffman, T.J.; and Smith, C.J. “Copper-64 Bombesin Conjugates for Specific Targeting of Human Cancers.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, May, 2011.

12. Cai, Q.; Nanda, P.; Sieckman, G.; Smith, J.; Hoffman, T.; Yu, P.; and Ma, L. “Quantitative Detection of Circulating Cancer Cells in Mouse Blood Using Fluorescent Bombesin.” University of Missouri Life Sciences Week, Columbia, MO, April 18-20, 2011.

13. Nanda, P.K.; Pandey, U.; Bottenus, B.N.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.; and Smith, C.J. “In Vitro and In Vivo Evaluation of 64Cu Bombesin Antagonists as Potential Agents for Prostate Cancer Imaging.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, May, 2010.

14. Price, S.; Nanda, P.; Cai, Q.; Smith, J.; Sieckman, G.; Hoffman, T.; and Ma, L. “In Vitro and In Vivo Evaluation of an MRI Contrast Agent Targeting Human Prostate Cancer.” University of Missouri Life Sciences Week, Columbia, MO, April 12-15, 2010.

15. Nanda, P.K.; Pandey, U.; Bottenus, B.N.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.; and Smith, C.J. “In Vitro and In Vivo Evaluation of 64Cu Bombesin Antagonists as Potential Agents for Prostate Cancer Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 12-15, 2010.

16. Hujala, N.; Smith, C.J.; Sieckman, G.L.; Hoffman, T.J.; Volkert, W.; Ma, L.; and Yu, P. “Frequency Domain Fluorescent Molecular Tomographic System for Small Animal Imaging Using a Near-infrared Fluorescent Probe.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2009.

17. Zhai, H.; Nanda, P.; Smith, J.; Lin H.; Yu, P.; Sieckman, G.; Hoffman, T.; Sethi, Y.; and Ma, L. “Multifunctional Optical/MRI Contrast Agents for Prostate Cancer Molecular Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2009.

18. Zhai, H.; Prasanphanich, A.; Smith, C.J.; Kujula, N.; Sieckman, G.; Hoffman, T.J.; Volkert, W.A.; and Ma, L. “Multifunctional MRI Contrast Agents Based On Super Paramagnetic Iron Oxide Nanoparticles.” University of Missouri Health Sciences Research Day, Columbia, MO, November , 2008.

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19. Lane, S.R.; Jurisson, S.S.; and Smith, C.J. “Development of Copper-64 Bombesin Conjugates for Use as Prostate Cancer Imaging Agents.” University of Missouri Health Sciences Research Day, Columbia, MO, November , 2008.

20. Retzloff, L.; and Smith, C.J. “A Novel Series of 99mTc-Bombesin Conjugates for Diagnostic Imaging of Breast Carcinoma.” University of Missouri Health Sciences Research Day, Columbia, MO, November, 2008.

21. Strattman, M.; and Smith, C.J. “Investigation of a Dual Modality Radiolabeled Bioconjugate for Human Cancer Imaging.” University of Missouri Health Sciences Research Day, Columbia, MO, November, 2008.

22. Ma, L.; Morgan, B.; Brown, A.; Sublett, S.; Kujala, N.; Zhai, H.; Smith, C.J.; Figueroa, S.D.; Yu, P.; Hoffman, T.J.; and Volkert, W.A. “Functional Apparent Diffusion Coefficient Mapping of Uptake of Tumor-targeting Bombesin Agents in Human Breast and Prostate Cancer Xenografts.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, May 23, 2008.

23. Liu, D.; Overbey, D.; Watkinson, L.; Sieckman, G.; Figueroa, S.D.; Hoffman, T.J.; Smith, C.J.; Forte, L.R.; Volkert, W.A.; and Giblin, M.F. “In Vivo Imaging of GC-C Expression.” United States Department of Veterans’ Affairs Research Day, Columbia, MO, May 16, 2008.

24. Kujala, N.; Zhai, H.; Smith, C.J.; Sieckman, G.L.; Hoffman, T.J.; Volkert, W.; Ma, L.; and Yu, P. “A New Near-infrared Fluorescent Bombesin Conjugate Extended to Wavelength 750nm.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2008.

25. Kan, P.; Rahing, V.N.; Watkinson, L.D.; Lever, J.; Smith, C.J.; Loyalka, S.K.; Katti, K.V.; Katti, K.K.; Cutler, C.S.; and Jurisson, S. S. “The Potential of Gum Arabic Stabilized Au-198 Nanoparticles (GA-AuNP) as a Radiotherapeutic Agent for Prostate Cancer.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2008.

26. Lane, S.R.; Prasanphanich, A.F.; Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; Jurisson, S.S.; and Smith, C.J. “Copper-64 Bombesin Conjugates for Potential Prostate Cancer Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2008.

27. Boote, E.; Smith, J.; Lever, J.; Watkinson, L.; Carmack, T.; Robertson, D.; Katti, K.; Kannan, R.; and Katti, K. “Gold Nanoparticles as a Computed Tomography Contrast Agent in SCID Mice with PC-3 Xenografts.” University of Missouri Life Sciences Week, Columbia, MO, April 14-16, 2008.

28. Prasanphanich, A.; and Smith, C.J. “In Vitro and In Vivo Analysis of 64Cu-NOTA-8-

Aoc-BBN PET Imaging Bioconjugate for Human Breast Cancer.” University of Missouri Health Sciences Research Day, Columbia, MO, November 10, 2007.

29. Heinzke, L.; and Smith, C.J. “Investigation of Gastrin Releasing Peptide Receptor-Specific 99mTc Conjugates.” University of Missouri Health Sciences Research Day, Columbia, MO, November 10, 2007.

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30. Smith, C.J. “Molecular Imaging of Gastrin Releasing Peptide Receptor-Expressing Tumors.” The Harry S. Truman Memorial Veterans’ Hospital Research Seminar Series, Columbia, MO, July 10, 2007.

31. Heinzke, L.; Prasanphanich, A.; Lane, S.; Retzloff, L.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; and Smith, C.J. “In Vitro/In Vivo Assessment of Novel 99mTc-Bombesin Conjugates in Human Cancer Tissue.” University of Missouri Life Sciences Week, Columbia, MO, April 16-20, 2007.

32. Prasanphanich, A.F.; Ma, L.; Yu, P.; Rold, T.L.; Hoffman, T.J.; Figueroa, S.D.; Sieckman, G.L.; and Smith, C.J. “Imaging of Human Breast and Prostate Cancer Xenografts Using Bombesin-based Molecular Imaging Probes.” University of Missouri Life Sciences Week, Columbia, MO, April 16-20, 2007.

33. Prasanphanich, A.F.; Nanda, P.K.; Rold, T.L.; Hoffman, T.J.; and Smith, C.J. “Evaluation of a New Series of Copper-64-NOTA-Bombesin Targeted Radiopharmaceuticals with PET Imaging Potential.” Spring Forum on Undergraduate Research, Columbia, MO, April 30, 2007.

34. Pacheco, D.; Ma, L.; Smith, C.; Hoffman, T.; and Yu, P. “Development of Tissue Phantoms for Multimodality Optical/MRI Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 16-20, 2007.

35. Figueroa, S.D.; Garrison, J.C.; Rold, T.L.; Sieckman, G.L.; Ma, L.; Smith, C.J.; Volkert, W.A.; and Hoffman, T.J. “Functional SPECT Tumor Imaging of GRP Receptor Expression.” University of Missouri Life Sciences Week, Columbia, MO, April 16-20, 2007.

36. Heinzke, L.; Prasanphanich, A.; Lane, S.; Retzloff, L.; Rold, T.L.; Sieckman, G.L.;

Hoffman, T.J.; and Smith, C.J. “In Vitro/In Vivo Assessment of Novel 99mTc-Bombesin Conjugates in Human Cancer Tissue.” Spring Forum on Undergraduate Research, Columbia, MO, April 30, 2007.

37. Prasanphanich, A.; and Smith, C.J. “Initial Evaluation of a New Series of Copper-64-NOTA-Bombesin Targeted Radiopharmaceuticals with PET Imaging Potential.” University of Missouri Health Sciences Research Day, Columbia, MO, November 10, 2006.

38. Figueroa, S.D.; Garrison, J.C.; Rold, T. L.; Sieckman, G.L.; Ma, L.; Smith, C.J.; Volkert, W.A.; and Hoffman, T.J. “MicroSPECT Quantification and Molecular Imaging of GRP Expressing Tumors.” University of Missouri Health Sciences Research Day, Columbia, MO, November 10, 2006.

39. Prasanphanich, A.; and Smith, C.J. “Synthesis and Characterization of Bombesin Derivatives with Potential Application as Nuclear Medicine Imaging/Therapeutic Agents.” University of Missouri: 2006 MU Summer Undergraduate Research and Creative Achievements Forum, Columbia, MO, August 3, 2006.

40. Balasubramanian, S.; Kujala, N.G.; Pacheco, D.; Yu, P.; Ma, L.; and Smith, C.J. “Designing a Frequency Domain Heterodyne System for 3D Diffused Photon

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Fluorescence Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 17-21, 2006.

41. Rold, T.L.; Garrison, J.C.; Sieckman, G.L.; Carter, S.N.; Bell, N.R.; Smith, C.J.;

Cutler, C.S.; Ketring, A.R.; and Hoffman, T.J. “Targeting BB2 Receptor Expression in Prostate Cancer Using Promethium-149 Labeled Peptides.” University of Missouri Life Sciences Week, Columbia, MO, April 17-21, 2006.

42. Hoffman, T.J.; Rold, T.L.; Sieckman, G.L.; Smith, C.J.; Volkert, W.A.; and Perry, M.C. “BB2 Receptor Targeted Radiotherapy Combined with Chemotherapy for the Treatment of Pre-clinical Xenograft Models of Breast Cancer.” University of Missouri Life Sciences Week, Columbia, MO, April 17-21, 2006.

43. Figueroa, S.D.; Ma, L.; Rold, T. L.; Sieckman, G.L.; Smith, C.J.; Garrison, J.C.; Volkert, W.A.; and Hoffman, T.J. “In Vivo Molecular and Anatomical Fused Modality Imaging for Radiotracer Localization of Bombesin BB2 Receptor Expressing Tumors.” University of Missouri Life Sciences Week, Columbia, MO, April 17-21, 2006.

44. Yu, P.; Ma, L.; and Smith C.J. “Development of 3D Fluorescence Molecular Tomography for Fusion Imaging.” A Report to the NIH External Advisory Committee for P50 Developmental Project #4. The University of Missouri, Columbia, MO, March 15, 2006.

45. Veerendra, B.; Prasanphanich, A.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.L.; Matson, G.; Retzloff, L.; McCrate, J.; and Smith, C.J. “Synthesis, Radiolabeling and In Vitro GRP Receptor Targeting Studies of 99mTc-TRIAZA-X-BBN[7-14]NH2 (X = Serylserylserine, Glycylglycylglycine, Glycylserylglycine, or Beta Alanine).” University of Missouri Health Sciences Research Day, Columbia, MO, November 10, 2005.

46. Prasanphanich, A.; Veerendra, B.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.L.; Matson, G.; Retzloff, L.; McCrate, J.; and Smith C.J. “Radiochemical Investigations of a New Series of GRP Receptor Targeting Radiopharmaceuticals.” University of Missouri Health Sciences Research Day, Columbia, MO, November 10, 2005.

47. Figueroa, S.D.; Winkelmann, C.T.; Rold, T. L.; Sieckman, G.L.; Smith, C.J.; and Hoffman, T.J. “Characterization of a Dual Head Pinhole SPECT/CT with Sub-millimeter Resolution for laboratory Animal Molecular Imaging.” University of Missouri Life Sciences Week, Columbia, MO, April 11-14, 2005.

48. Ma, L.; Smith, C.J.; Sieckman, G.L.; Volkert, W.A.; and Hoffman, T.J. “Structural Characterization of DOTA-8-AOC-Bombesin(7-14)NH2: A Case Study of Tumor Targeting Diagnostic/Therapeutic Analogues Using NMR Spectroscopy.” University of Missouri Life Sciences Week, Columbia, MO, April 11-14, 2005.

49. Retzloff, L.; Alves, S.; Santos, I.; Hoffman, T.J.; Sieckman, G.L.; Rold, T.; Prasanphanich, A.; McCrate, J.; and Smith, C.J. “Technetium(I) Pyrazolyl Conjugates of Bombesin: A potentially New Radiotracer for Targeting of the Gastrin Releasing Peptide Receptor.” University of Missouri Life Sciences Week, Columbia, MO, April 11-14, 2005.

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50. Smith, C.J. “Non-traditional Radiolabeling Methods for Production of Technetium-based Conjugates: A Concise In Vitro and In Vivo Study.” The Harry S. Truman Memorial Veterans’ Hospital Research Seminar Series, Columbia, MO, January 11, 2005.

51. Smith, C.J. “Non-traditional Radiolabeling Methods for Production of Technetium-based Conjugates: A Concise In Vitro and In Vivo Study.” A Presentation to the Department of Medical Physiology and Pharmacology, University of Missouri, Columbia, MO, March 7, 2005.

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II. TEACHING

Teaching/Training of Undergraduate Students:

Ms. Nicole BernskoetterMentorship Role: Research Mentor (2012)B.S. in Nuclear Medicine Technology, University of Missouri.

Ms. Regan MurphyMentorship Role: Research Mentor (2012)B.S. in Nuclear Medicine Technology, University of Missouri.

Mr. Alex HeckMentorship Role: Research Mentor (2012)Pre-Medicine, University of Missouri.

Ms. Jasmine Cooper:Mentorship Role: Research Mentor (2010)B.S. Student of Biology, University of Missouri.

Mr. Christopher Faron:Mentorship Role: Research Mentor (2010)B.S. Student of Biology, University of Missouri.

Ms. Brie Weinhoff:Mentorship Role: Research Mentor (2010)B.S. in Nuclear Medicine Technology, University of Missouri.

Ms. Monica Strattman:Mentorship Role: Research Mentor (2008)B.S. in Chemistry and Russian, University of Missouri.

Mr. Adam Prasanphanich: Mentorship Role: Research Mentor (2004-2008)B.S. in Chemistry and Mathematics, University of Missouri.Life Sciences Undergraduate Research Opportunity Program Scholar and Research Ambassador for the University of Missouri System.LSUROP Thesis Title: “In Vitro/In Vivo Assessment of New 64Cu-Bombesin Conjugates in Human Breast Cancer Tissue.”

Ms. Lauren Lynn Heinzke: Mentorship Role: Research Mentor (2006-2008) B.S. in Chemistry and Biology, University of Missouri.Life Sciences Undergraduate Research Opportunity Program ScholarLSUROP Thesis Title: “99mTc-DPR-SSS-BBN for Diagnosis of Human Cancers.”

Mr. Nicholas MessinaMentorship Role: Research Mentor (2007) B.S. in Nuclear Medicine Technology, University of Missouri.

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Mr. Richard CopithorneMentorship Role: Research Mentor (2007) B.S. in Nuclear Medicine Technology, University of Missouri.

Ms. Anita Heinzke: Mentorship Role: Research Mentor (2007) B.S. in Chemical Engineering, University of Missouri-Rolla.

Mr. Joseph McCrate: Mentorship Role: Research Mentor (2004/2005)B.S. in Chemical Engineering, University of Missouri.

Ms. Gretchen Matson: Mentorship Role: Research Mentor (2005) B.S. in Biology, University of Missouri.

Ms. Lauren Retzloff: Mentorship Role: Research Mentor (2004)B.S. in Biology, University of Missouri.

Teaching/Training of Graduate Students:

Mr. Zongrun Jiang: Mentorship Role: Ph.D. Committee Member and Co-advisor Ph.D. Student in Chemistry, University of Missouri, Department of Chemistry, August 2011-. Ph.D. Dissertation Advisor: Professor Silvia Jurisson, Department of Chemistry Thesis Title: TBA

Dr. Tamila Stott-Reynolds: Mentorship Role: Ph.D. Committee Member and Co-advisor The Comparative Medicine Residency Program, University of Missouri College of Veterinary MedicineDoctor of Veterinary Medicine, Texas A&M University, College Station, TexasPh.D. Student in Pathobiology, University of Missouri College of Veterinary Medicine, Department of Veterinary Pathobiology, August 2011-. Ph.D. Dissertation Advisor: Professor Craig Franklin, Department of Veterinary Pathobiology Thesis Title: TBA

Dr. Teresa Esteves: Mentorship Role: Research MentorVisiting Scholar Program, University of MissouriPh.D. in Pharmacy Department, Instituto Tecnologico e Nuclear, Estrada Nacional 10, Apartado 21, POR-2686953 Sacavem, Portugal. Ph.D. Dissertation Advisor: Professor Isabel Santos. Dissertation Title: “Complexes of Gamma Radiation and Auger Electron Emitters for Diagnosis and/or Therapy of Cancer.”Visiting Scholar Project at the University of Missouri-Columbia: Evaluation of New 99mTc-BBN Analogues for and Evaluation in Prostate Cancer Models.

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Dr. Ethan Balkin: Mentorship Role: Ph.D. Committee MemberPh.D. in Pathobiology, University of Missouri College of Veterinary Medicine, Department of Veterinary Pathobiology, August 2006-July 2011. Ph.D. Dissertation Advisor: Professor Michael Lewis, Veterinary Medicine Dissertation Title: “Targeted 177Lu Antisense Radiotherapy of B-Cell Non-Hodgkin’s Lymphoma.”

Dr. Stephanie Renee Lane: Mentorship Role: Ph.D. Committee Member and Co-advisorPh.D. in Chemistry, University of Missouri, Department of Chemistry, August 2004-December 2009. Ph.D. Dissertation Advisor: Professor Silvia Jurisson, Department of ChemistryDissertation Title: “ReV and ReIII Sal2phen Complex Formation from Triphenylphosphine Addition and Prostate Cancer Imaging and Therapy Agents: 99mTc(CO)3-DTMA-, 64Cu-NOTA-, and Bi-CHX-A″-Bombesin.”

Dr. Lauren Retzloff: Mentorship Role: Ph.D. Committee Member and Co-advisorPh.D. in Medical Pharmacology and Physiology, University of Missouri School of Medicine, Department of Medical Pharmacology and Physiology, August 2005-September 2009. Ph.D. Dissertation Advisor: Professor Leonard Forte, Medical Pharmacology and Physiology Dissertation Title: “Design, Synthesis, and Evaluation of Radiolabeled Bombesin Conjugates for the Diagnosis of Breast Cancer.”

Dr. Susana Alves: Mentorship Role: Ph.D. Committee Member and Primary Juror of Dissertation DefenseVisiting Scholar Program, University of MissouriPh.D. in Pharmacy Department, Instituto Tecnologico e Nuclear, Estrada Nacional 10, Apartado 21, POR-2686953 Sacavem, Portugal. Ph.D. Dissertation Advisor: Professor Isabel Santos. Dissertation Title: “Complexos com a Unidade fac-[99mTc(CO)3]+ para o Desenvolvimento de Radiofarmacos Especificos para Receptores de Peptidos.”Visiting Scholar Project at the University of Missouri-Columbia: In Vitro and In Vivo Evaluation of [99mTc(CO)3-Cyclo[Arg-Gly-Asp-D-Tyr-Lys(PZ1)]] and [99mTc(CO)3- Cyclo[BBN(7-14)NH2]].

Mr. Moustapha Moustapha: Mentorship Role: M.S. Committee Member and Co-advisor Masters of Science in Chemistry, University of Missouri, Department of Chemistry, August 2004. Master’s Thesis Advisor: Professor Silvia Jurisson, Department of Chemistry Thesis Title: “A Comparative Study Between No-carrier Added Re-186, Carrier-added Re-186, and No-carrier Added Re-188 for Radiolabeling N3S-5-Ava-BBBN(7-14)NH2.”

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Teaching/Training of Medical Students:

Mr. Daniel Kirkpatrick:Mentorship Role: Research Mentor (2013)Academic Advisor: James Connors, M.D.M4 Medical Student, University of Missouri School of Medicine.

Mr. Kurt J. Bassuner:Mentorship Role: Research Mentor (2013)Academic Advisor: James Connors, M.D.M4 Medical Student, University of Missouri School of Medicine.

Teaching/Training of Post-Doctoral Fellows:

Dr. Rajendra Prasad Bandari:Mentorship Role: Post-doctoral Research AdvisorMaster of Science in Chemistry (First Division), Kakatiya University, Warangal, India 2000.Ph.D. in Organic/Medicinal Chemistry, Indian Institute of Chemical Technology, Hyderabad, India.Ph.D. Advisor: Professor Ahmed KamalThesis Title: Design and Synthesis of New Pyrrolo[2,1-c][1,4]benzodiazepine Hybrids and Related Compounds as Potential Anticancer Agents.Project Title: Heterodimeric Targeting Vectors with High Selectivity for the PSMA and the GRPR.

Dr. Kubra Durkan:Mentorship Role: Post-doctoral Research AdvisorMaster of Science in Biochemistry, Faculty of Medicine, Celal Bayar University, Mansia, Turkey 2001.Ph.D. in Nuclear Applications, Institute of Nuclear Sciences, Ege Universtiy, Izmir, Turkey 2008.Ph.D. Advisor: Professor Fatma Yurt LambrechtThesis Title: Investigation of Labeling Methods of Bombesin-like Peptide Litorin with Technetium-99m and Evaluation of Radiopharmaceutical Potential.Project Title: Development of Novel Heterodimeric Targeting Vectors having High Selectivity Human Cancer Cells.

Dr. Pablo Cabral Gonzalez:Mentorship Role: Post-doctoral Research Advisor Master of Science in Chemistry, Universidad de la Republica Uruguay Ph.D. Candidate in Chemistry, Universidad de la Republica Uruguay Ph.D. Advisor: Professor Heni A. Baler Project Title: Melanoma Imaging/Therapy via New Peptide Conjugates.

Dr. Andrew B. Jackson:Mentorship Role: Post-doctoral Research AdvisorPh.D. in Inorganic Chemistry, The University of North Carolina at Chapel Hill, August 2008.Ph.D. Advisor: Professor Joseph L. Templeton

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Thesis Title: Nitrile Reduction and Carbon Monoxide Replacement in Tungsten (II) Bis(Acetylacetonate) Complexes.Project Title: Design and Development of Heterodimeric Targeting Vectors for Human Cancers.

Dr. Usha Saket Padney:Mentorship Role: Post-doctoral Research Advisor Master of Science in Chemistry, University of Madras, Tamil Nadu, India 1996. Ph.D. in Applied Biology, Mumbai University, February 2008Ph.D. Advisor: Professor Meera Venkatesh, Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India 400 085. Thesis Title: Preparation and Bioevaluation of Therapeutic Radiopharmaceuticals. Project Title: New Radiopharmaceuticals Based Upon Tc(I)/Re(I)/Cu(II) Bombesin Targeting Vectors.

Dr. Jens-Uwe Kuenstler:Mentorship Role: Visiting Scholar and Post-doctoral Research AdvisorVisiting Scholar Program, University of Missouri Ph.D. in Chemistry, Forschungszentrum Rossendorf (FZR), Institute of Bioinorganic and Radiopharmaceutical Chemistry, Dresden, Germany 2004. Ph.D. Advisor: Professor Hans-Jurgen Pietzsch Thesis Title: Beitrag zur Praeparation und Charakterisierung Technetiummarkierter Antikoerper und Peptide. Project Title: In Vitro and In Vivo Evaluation of [99mTc(4+1)-[BBN(7-14)NH2]-Conjugates].

Dr. Prasant Kumar Nanda:Mentorship Role: Post-doctoral Research Advisor Master of Science in Chemistry (Advanced Inorganic Chemistry Specialization), Utkal University, Orissa, India 1999. Ph.D. in Chemistry, Indian Institute of Technology, Kharagpur, India 2006. Ph.D. Advisor: Professor Debashis RayThesis Title: Studies on the Coordination Chemistry of 3d Transition Elements with Multidentate Ligands: Mono-, Di-, and Tetranuclear Complexes.Project Title: Transition Metal Complexes of Polydentate, Main-group Ligands.

Dr. Veerendra Bhadrasetty:Mentorship Role: Post-doctoral Research Advisor Master of Science in Chemistry, Gulberga University, Gulberga, India 1999. Ph.D. in Organic Chemistry, Manglore University, Manglore, India 2003. Ph.D. Advisor: Professor Shivarama HollaThesis Title: Synthetic Studies of Some Simple and Bis-Heterocycles: Their Characterization and Applications.Project Title: Design and Development of Specific Bifunctional Chelating Ligands for Tc(I)/Re(I).

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Teaching/Training of Radiology Residents:

Radiology Resident Training in Nuclear Medicine:Function: Course Coordinator and InstructorDesign: This Course is a 2 Hour Short Course in 99mTc-generator and Radiopharmaceutical Design Necessary for Resident Radiology Accreditation in Nuclear MedicineYears Taught: Fall Semester, 2004-2013

Classroom/Course Teaching at the University of Missouri:

Problem Based Learning Program, M2 Medical Students: Function: PBL TutorDesign: This Course is Taught by Jeff SmithYears Taught: Winter 2012, 2014Course Title: Pathophysiology 4, Block 8

Problem Based Learning Program, M2 Medical Students: Function: PBL TutorDesign: This Course is Taught by Jeff SmithYears Taught: Fall 2012Course Title: Pathophysiology 4, Block 5

Introductory Radiation BiologyFunction: Instructor (2 Lectures)Design: This Course is Team Taught by Drs. Mike Lewis, Wynn Volkert, and Jim LattimerYears Taught: Fall Semester, 2010Course Title: RADIOL 8085-01

Radiopharmaceuticals in Nuclear Medicine: Function: Course Coordinator and InstructorDesign: This Course is Team Taught by Drs. Wynn Volkert, Timothy Hoffman, and Jeff SmithYears Taught: Fall Semester, 2005-2013Course Title: NUCMED 4329/7329

Problem Based Learning Program, M2 Medical Students: Function: PBL TutorDesign: This Course was Team Taught by Drs. Robert Churchill, John Lever, and Jeff Smith. In 2009, an M4 Medical Student also Assisted with Teaching DutiesYears Taught: Winter Semester, 2006, 2007, 2008, 2009, 2011Course Title: Pathophysiology 4, Block 8

Problems in Radiology (Independent Teaching)Function: Course Coordinator and InstructorDesign: This Course is an Independent Learning Type of Study Offered through RadiologyYears Taught: Winter Semester, 2009Course Title: RADIOL 8085-01

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Undergraduate Research in Nuclear Medicine TechnologyFunction: Research MentorDesign: Laboratory Research Training During the SemesterYear Taught: Winter Semester, 2007Course Title: NUCMED 4085, Problems in Nuclear Medicine

Undergraduate Research in ChemistryFunction: Research MentorDesign: Laboratory Research Training During the SemesterYear Taught: Summer Semester, 2006Course Title: CHEM 4950

Training Programs for Higher Education:

Teaching Renewal ConferenceFebruary 22-23, 2007Reynolds Alumni Center, University of Missouri Campus

Teaching Renewal ConferenceFebruary 23-25, 2006Memorial Union, University of Missouri Campus

Building Your Academic PortfolioSeptember 28-30, 2006Lodge of the Four Seasons, Lake of the Ozarks

New Faculty Teaching Scholars ProgramMonthly Meetings: 2005/2006.

Course Design Retreat ConferenceOctober 6-8, 2005Tan-Tar-A Resort, Lake of the Ozarks

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III. SERVICE and OUTREACH

Professional and Honorary Societies:

2008-present Radiopharmaceutical Sciences Council, The Society of Nuclear Medicine

2005-present International Association of Radiopharmacology2002-present The International Society of Radiopharmaceutical

Chemistry and Biology2002-2006 International Consultant to the IAEA1998-present The Society of Nuclear Medicine, Member1995-present American Chemical Society, Member

Editorial Boards (Current):

Journal of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Compounds

World Journal of Radiology World Journal of Gastrointestinal Pharmacology and

Therapeutics Austin Radiology Austin Journal of Nuclear Medicine and Radiotherapy

Editorial Boards (Past):

ISRN Molecular Imaging (Ended in 2013)

Professional Reviews (Grants, Manuscripts, Presentations):

Organizing Committee: International Society of Radiopharmaceutical Sciences 21st

Annual Symposium, Columbia, Missouri May 26-31, 2015.Reviewer of Abstracts: International Society of Radiopharmaceutical Sciences 21st

Annual Symposium, Columbia, Missouri May 26-31, 2015.Administrator for Exam: Ms. Edyta Leszczuk, Postgraduate Program in

Radiopharmaceutical Chemistry/Radiopharmacy, European Association of Nuclear Medicine, August 2014.

Reviewer of Applications: National Research Foundation of South Africa, August, 2014.

Reviewer of Grants: Department of Defense Congressionally Directed Medical Research Programs, Breast Cancer Research Program (BCRP), Nanotechnology (NT) Peer Review Panel, July, 2014.

Reviewer of Grants: Department of Defense Congressionally Directed Medical Research Programs, Prostate Cancer Research Program (PCRP), 2013.

Reviewer of Applications: Spurgeon Award, University of Missouri School of Medicine, Columbia, MO, September, 2013.

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Reviewer of Abstracts: International Society of Radiopharmaceutical Sciences 20th

Annual Symposium, Jeju, Korea, May 12-17, 2013.Reviewer of Posters: Systems Biology, Modeling, and Technology Development

Symposia at University of Missouri Life Sciences Week, Columbia, MO, April, 2006, 2008, 2011, 2014.

Reviewer of Posters: University of Missouri Undergraduate Research & Creative Achievements Forum, Life Sciences Division, Columbia, MO, April 26, 2011.

Reviewer of Grants: Research Board Grants, University of Missouri System, 2005, 2011.

Reviewer of Grants: European Cooperation in Science and Technology, COST, 2008.

Reviewer of Grants: VISN 15 Awards, 2008.Reviewer of Grants: Children’s Miracle Network Application, University of

Missouri, 2005, 2006, 2007.Reviewer of Grants: Summer Fellowship Opportunities, University of Missouri

School of Medicine, 2005, 2006, 2007.Reviewer of Grants: National Institute of Allergy and Infectious Disease,

National Institutes of Health, 2006.Reviewer of Posters: University of Missouri Health Sciences Research Day,

November 2004, 2005, 2006.Reviewer of Grants: American Cancer Society, 2004-2005Reviewer of Manuscripts:

Inorganic Chemistry Journal of Pharmacy and Pharmacology Journal of Synthesis and Reactivity in Inorganic, Metal-

Organic, and Nano-Metal Compounds Journal of the American Chemical Society Journal of Labeled Compounds and Radiopharmaceuticals Journal of Organometallic Chemistry Medicinal Research Reviews Bioconjugate Chemistry Cellular and Molecular Biology Accounts of Chemical Research Molecular Imaging European Journal of Nuclear Medicine Nuclear Medicine & Biology Applied Radiation and Isotopes Regulatory Peptides Chemical Reviews Journal of the Royal Society of Chemistry, Dalton

Transactions Journal of the Royal Society of Chemistry, Chemical

Communications International Journal of Cancer Journal of Nuclear Medicine Current Organic Synthesis Amino Acids Bioorganic & Medicinal Chemistry Bioorganic & Medicinal Chemistry Letters

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Current Pharmaceutical Design Letters in Drug Design & Discovery Current Pharmaceutical Design Theranostics European Journal of Nuclear Medicine and Molecular

Imaging World Journal of Radiology Journal of Visualized Experiments Nature Molecular Pharmaceutics ACS Medicinal Chemistry Letters Current Radiopharmaceuticals Radiochimica Acta

Professional Committees and Programs (University of Missouri and HSTMVH):

2014-present Vice Chairperson, Research and Development Committee, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2012-present Research Council, University of Missouri School of Medicine, Columbia, MO 65211

2011-present Subcommittee for Position Classification, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2010-present Department of Radiology Promotion and Tenure Committee, University of Missouri School of Medicine, Columbia, MO 65211

2010-present Faculty Mentor, Mizzou Archery2009-2013 Member, Subcommittee for Research Safety, United

States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2009-present Schedule of Classes Person of Contact, Department of Radiology, University of Missouri School of Medicine, Columbia, MO 65211

2007-present Radiation Safety Committee (RSC), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2007-present Research and Development Committee, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2006-present Radiation Safety Committee (RSC), University of Missouri, Missouri University Research Reactor, Columbia, MO 65211

2004-present Subcommittee for Isotope Use (IUS), Missouri University Research Reactor, Columbia, MO 65211

2004-present Member of University of Missouri Graduate Faculty, University of Missouri, Columbia, MO 65211

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2004-present Member of University of Missouri Doctoral Faculty, University of Missouri, Columbia, MO 65211

2009 Ex-officio Member, Subcommittee for Research Safety, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2007 Position Search Committee, Ex Officio Member, Department of Veterinary Medicine and Surgery, University of Missouri-Columbia, Columbia, MO 65211

2006-2007 Director, HSTMVH Research Service Research Seminar Series

2005-2006 New Faculty Teaching Scholars Program, University of Missouri, Columbia, MO 65211

2005 Position Search Committee, Committee Member, Department of Radiology, University of Missouri School of Medicine, Columbia, MO 65211

2005-2008 Student Fee Capital Improvements Committee, University of Missouri, Columbia, MO 65211

2004-2008 Subcommittee for Animal Studies, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2004-2007 Research Council, University of Missouri School of Medicine, Columbia, MO 65211

2004-2006 Associate Chief of Staff’s Advisory Committee, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

Service to The United States of America:

2014-present Research Health Scientist Appointment (Grade 14, Step 6), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2010-2014 Research Health Scientist Appointment (Grade 14, Step 5), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2002-2006 Ambassador of the United States of America to the International Atomic Energy Agency, Vienna, Austria

2005-2010 Research Scientist Appointment (Grade 13, Step 7), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2003-2005 Research Scientist WOC Appointment, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

2000-2003 Research Chemist WOC Appointment, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO 65201

1992-present Disabled American Veteran

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1992 Honorable Discharge, United States Army Reserve1990-1992 United States Army Reserve

Service to Columbia/Missouri Affiliations:

2011-present Treasurer, Archery Big Bucks of Missouri2009-present Recording Secretary, Archery Big Bucks of Missouri2005-2006 Chairperson to the Board of Trustees, Trinity Lutheran

Church2004-2006 President, Barclay Ridge Homeowners Association2003-2004 Vice-President, Barclay Ridge Homeowners Association2003-2005 Member of the Board of Trustees, Trinity Lutheran Church2004-2005 Board of Directors, Trinity Lutheran Church

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cv-smith-2014-updated

Documents

research assistant professor

adjunct associate professor

present associate professor

adjunct assistant professor

research scientist grade

university of missourischool

department of internalmedicine

university of missouricolumbia