dan-thanh nguyen biology 402 march 20, 2012. symptoms: fever sore throat weakness headache ...
TRANSCRIPT
EBOV is a viral hemorrhagic fever with an incubation
period of 2-21 days
Symptoms: Fever Sore throat Weakness Headache Muscle aches Diarrhea Vomiting Severe hemorrhaging
Ebola has a high case fatality ratio of 25-90%
http://www.all-science-fair-projects.com/science_fair_projects_encyclopedia/Ebola
Ebola has nonhuman hosts
http://www.reviews-technology.com/2010_08_24_archive.html
Candidate reservoir hosts are mammals of small body size, and
asymptomatic
http://www.mnzoo.org/faces/fruit-bat/
http://www.who.int/csr/disease/ebola/Global_EbolaOutbreakRisk_20090510.png
Ebola is in the family of filoviruses and a cousin of the Marburg Virus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/?tool=pmcentrez
Ebola virus is subdivided into five different species based on where
they were discovered
Zaire (Democratic Republic of Congo)
Sudan Cote d’Ivoire (Ivory Coast) Reston Bundibugyo
Ebola is an enveloped, single-stranded RNA virus
http://viralzone.expasy.org/all_by_species/23.html
Ebola virus has a negative strand RNA genome
Nucleoprotein
Virion protein 35
Virion protein 40
Virion protein 30
Virion protein 24
GlycoproteinSoluble
glycoprotein
polymerase
http://viralzone.expasy.org/all_by_species/23.html
During replication, full-length positive-sense copies of the genome are synthesized
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/?tool=pmcentrez
Filoviruses have broad tissue tropism but have preferred target cells
Hepatocytes Endothelial cells Dendritic cells Monocytes Macrophages
EBOV accelerates the release of pro-inflammatory cytokines
http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v3/n8/full/nri1154.html#f3
http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v7/n7/full/nri2098.html
Hemorrhaging is related to disseminated intravascular coagulation
(DIC) and increase in tissue factor in macrophages
http://jid.oxfordjournals.org/content/188/11/1618.full
There is currently no definitive vaccine for Ebola virus.
http://buquad.com/2011/10/17/bu-biolab/
http://www.nationalpost.com/related/topics/Canadian+scientists+develop+Ebola+treatment/3083100/story.html
Resources
Dolnik, O.; L. Kolesnikova, and S. Becker. “Filoviruses: Interactions with the host cell.” Cellular and Molecular Life Sciences Vol 65. 756-776. 2008. http://www.springerlink.com/content/fk38279221156248/
“Ebola haemorrhagic fever.” World Health Organization. Dec 2011. http://www.who.int/mediacentre/factsheets/fs103/en/
“Ebola virus disease.” Wikipedia. http://en.wikipedia.org/wiki/Ebola_virus_disease Feldmann, Heinz; Steven Jones, Hans-Dieter Klenk; and Hans-Joachim Schnittler.
“Ebola virus: from discovery to vaccine.” Nature Reviews Immunology. Vol 3. 677-685 (August 2003). http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v3/n8/full/nri1154.html#f3
Geisbert, Thomas et al. “Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages is a Key Event.” Journal of Infectious Diseases. Vol 188. 1618-1629. 2003. http://jid.oxfordjournals.org/content/188/11/1618.full.pdf+html
Mohamadzadeh, Mansour; Leiping Chen; and Alan L. Schmaljohn. “How Ebola and Marburg viruses battle the immune system.” Nature Reviews Immunology. Vol 7. 556-567 (July 2007). http://www.nature.com.libproxy.lib.unc.edu/nri/journal/v7/n7/full/nri2098.html
Takada, Ayato. “Filovirus Tropism: Cellular Molecules for Viral Entry.” Frontiers in Microbiology. 06 February 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277274/pdf/fmicb-03-00034.pdf