data uji pelepasan obat - suppositoria asam salisilat (1)

8/19/2019 Data Uji Pelepasan Obat - Suppositoria Asam Salisilat (1)

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Kurva Baku Panjang Gelombang Maksimum : 525 nm

C (ppm) A

6 0.2273

9 0.371112 0.4967

15 0.6194

18 0.7329

a -0.01432

b 0.0419833333

r 0.9990470195

4 6 8 10 12 14 16 18 200

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8


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Column B


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F1-R1 F1-R2 F1-R3 F

Absorbansi % Ckumulatif Absorbansi % Ckumulatif Absorbansi % Ckumulatif Absorbansi

5 0.2388 0.5424 0.2410 0.5471 0.2264 0.5158 0.3610

10 0.3910 1.4156 0.3876 1.4130 0.3821 1.3698 0.4977

15 0.4588 2.4327 0.4611 2.4351 0.4587 2.3867 0.5810

20 0.5211 3.5839 0.5321 3.6099 0.5314 3.5600 0.6987

25 0.6692 5.0534 0.6722 5.0859 0.6688 5.0287 0.7986

30 0.7965 6.7966 0.7846 6.8035 0.8010 6.7816 0.2947

35 0.2314 12.0792 0.2510 12.5075 0.2547 12.5651 0.4454

0 0.3697 20.3353 0.3872 21.1398 0.3712 20.8534 0.5386

50 0.4891 31.1585 0.4629 31.3997 0.4763 31.4014 0.6327

!0 0.6525 45.4948 0.6347 45.3533 0.6479 45.6388 0.6987

Ke : an!a "#$ men%aakan &engen'e(an 10)

F1-R1Absorbansi Ct (m"#$) C00 Csuppo (%) Fk Ck (%)

5 0.3689 9.1238 9.1238 8.2114 0.8211 0.0000 0.8211

10 0.4920 12.0548 21.1786 19.0607 1.9061 0.0064 1.9124

15 0.5787 14.1190 35.2976 31.7679 3.1768 0.0106 3.1874

20 0.6710 16.3167 51.6143 46.4529 4.6453 0.0155 4.6608

25 0.7922 19.2024 70.8167 63.7350 6.3735 0.0213 6.3948

30 0.2889 7.2190 78.0357 70.2321 7.0232 0.0235 7.0467

35 0.4420 108.6429 186.6786 168.0107 16.8011 0.0561 16.8572

0 0.5297 129.5238 316.2024 284.5821 28.4582 0.0950 28.5533

50 0.6411 156.0476 472.2500 425.0250 42.5025 0.1420 42.6445!0 0.6925 168.2857 640.5357 576.4821 57.6482 0.1926 57.8408

*obs : Ka!a( +ba %ang ,e(uku( aa am&ling

* : Ka!a( +ba Kumulai aa /aku ilai lo&e "k$ : 1.05472

*900 : Ka!a( Kone(si !alam 900 m Me!ium

*su&&o : Pe(sen Ka!a( +ba %ang ,e(le&as !a(i e!iaan

k : ako( Ko(eksi ,ia& /aku

&aktu('nit)

&aktu('nit) Cobs (m"#$)


4/22

*k : Pe(sen Ka!a( +ba %ang ,e(le&as !a(i e!iaan eela !i Ko(eksi


5/22

2-R1 F2-R2 F2-R3

% Ckumulatif Absorbansi % Ckumulatif Absorbansi % Ckumulatif

0.8042 0.3741 0.8323 0.3689 0.8211

1.9077 0.4876 1.9141 0.4920 1.9124

3.1876 0.5922 3.2181 0.5787 3.1874

4.7206 0.6879 4.7279 0.6710 4.6608

6.4683 0.8076 6.4950 0.7922 6.3948

7.1327 0.3021 7.1753 0.2889 7.0467

17.0163 0.4317 16.7643 0.4420 16.8572

28.9037 0.5310 28.4883 0.5297 28.5533

42.8143 0.6477 42.7215 0.6411 42.6445

58.1440 0.6812 57.6749 0.6925 57.8408


6/22


7/22

F1

% lpasan Kumulaitf *+

R1 R2 R3 Rrata R1

0 0.5424 0.5471 0.5158 0.5351 0.0169 0.80425 1.4156 1.4130 1.3698 1.3994 0.0257 1.9077

10 2.4327 2.4351 2.3867 2.4182 0.0273 3.1876

20 3.5839 3.6099 3.5600 3.5846 0.0249 4.7206

25 5.0534 5.0859 5.0287 5.0560 0.0287 6.4683

30 6.7966 6.8035 6.7816 6.7939 0.0112 7.1327

35 12.0792 12.5075 12.5651 12.3839 0.2655 17.0163

0 20.3353 21.1398 20.8534 20.7762 0.4078 28.903750 31.1585 31.3997 31.4014 31.3199 0.1398 42.8143

!0 45.4948 45.3533 45.6388 45.4956 0.1428 58.1440

k 0.7913 0.7950 0.7985 1.0454

r 0.9984 0.9980 0.9984 0.9955

0.9968 0.9959 0.9967 0.9910

Formula +(!e ol

k

1 0.7949 0.0036 0.9965

2 1.0407 0.0043 0.9914

&aktu('nit)

r,

(


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1 2 3 4 5 6 7 8 9 100.0000

10.0000

Waktu 2


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F2

lpasan Kumulaitf *+

R2 R3 Rrata

0.8323 0.8211 0.8192 0.01411.9141 1.9124 1.9114 0.0033

3.2181 3.1874 3.1977 0.0177

4.7279 4.6608 4.7031 0.0368

6.4950 6.3948 6.4527 0.0519

7.1753 7.0467 7.1182 0.0655

16.7643 16.8572 16.8792 0.1274

28.4883 28.5533 28.6484 0.223442.7215 42.6445 42.7268 0.0851

57.6749 57.8408 57.8866 0.2379

1.0370 1.0395

0.9958 0.9958

0.9917 0.9916

0.0005

0.0004


10/22


11/22

&aktu vs % $n bat .r/isolusi

&aktu F1 F2 F1 F2

0 0.0000 0.0000 0.0000 0.00005 0.5351 0.8192 0.6254 0.1994

10 1.3994 1.9114 -0.3361 -0.6478

15 2.4182 3.1977 -0.8830 -1.1624

20 3.5846 4.7031 -1.2766 -1.5482

25 5.0560 6.4527 -1.6206 -1.8645

30 6.7939 7.1182 -1.9160 -1.9627

35 12.3839 16.8792 -2.5164 -2.82610 20.7762 28.6484 -3.0338 -3.3551

50 31.3199 42.7268 -3.4443 -3.7548

!0 45.4956 57.8866 -3.8176 -4.0585

*lop -0.0752 -0.0761

r -0.9785 -0.9827

05 0.9658

F1


R1 R2 R3 Rrata R1

0 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000

r,

&aktu('nit)


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0 3.0124 3.0512 3.0375 3.0337 0.0197 3.3640

50 3.4391 3.4468 3.4469 3.4442 0.0045 3.7569

!0 3.8176 3.8145 3.8208 3.8176 0.0031 4.0629

k 0.0749 0.0751 0.0757 0.0764r 0.9793141 0.9785996 0.9774149 0.9822558

0.959056 0.9576572 0.9553398 0.9648264

Formula +(!e au

k

1 0.0752 0.0004 0.9574

2 0.0761 0.0002 0.9658

r,

(


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F2

lpasan Kumulaitf *+

R2 R3 Rrata

0.0000 0.0000 0.0000 0.0000


14/22

3.3495 3.3518 3.3551 0.0078

3.7547 3.7529 3.7548 0.0020

4.0548 4.0577 4.0585 0.0041

0.0759 0.07610.9831174 0.9828364

0.9665197 0.9659675

0.0019

0.0009


15/22

Akar &aktu vs % bat .r/isolusi

&aktu Akar &aktu F1 F2

0 0.00 0.0000 0.00005 2.24 0.5351 0.8192

10 3.16 1.3994 1.9114

15 3.87 2.4182 3.1977

20 4.47 3.5846 4.7031

25 5.00 5.0560 6.4527

30 5.48 6.7939 7.1182

35 5.92 12.3839 16.87920 6.32 20.7762 28.6484

50 7.07 31.3199 42.7268

!0 7.75 45.4956 57.8866

*lop 5223 !!

r 03 02

0!32 0!32

Akar &aktu

F1


R1 R2 R3 Rrata

0 0 0.0000 0.0000 0.0000 0.0000 0.0000

5 2.24 0.5424 0.5471 0.5158 0.5351 0.0169

10 3.16 1.4156 1.4130 1.3698 1.3994 0.0257

15 3 87 2 4327 2 4351 2 3867 2 4182 0 0273

r,

&aktu('nit)


16/22

F2


R1 R2 R3 Rrata

0.0000 0.0000 0.0000 0.0000 0.0000

0.8042 0.8323 0.8211 0.8192 0.0141

1.9077 1.9141 1.9124 1.9114 0.0033

3 1876 3 2181 3 1874 3 1977 0 0177


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F1 F2

% lpasan Kumulaitf % lpasan Kumulaitf

R1 R2 R3 R1 R2 R3

5 0.5424 0.5471 0.5158 0.8042 0.8323 0.8211

10 1.4156 1.4130 1.3698 1.9077 1.9141 1.9124

15 2.4327 2.4351 2.3867 3.1876 3.2181 3.1874

20 3.5839 3.6099 3.5600 4.7206 4.7279 4.660825 5.0534 5.0859 5.0287 6.4683 6.4950 6.3948

30 6.7966 6.8035 6.7816 7.1327 7.1753 7.0467

35 12.0792 12.5075 12.5651 17.0163 16.7643 16.8572

0 20.3353 21.1398 20.8534 28.9037 28.4883 28.5533

50 31.1585 31.3997 31.4014 42.8143 42.7215 42.6445

!0 45.4948 45.3533 45.6388 58.1440 57.6749 57.8408

$o" t

$o" C

F1 F2

R1 R2 R3 R1 R2 R3

5 0.6990 -0.2657 -0.2620 -0.2875 -0.0946 -0.0797 -0.0856

10 1.0000 0.1509 0.1501 0.1366 0.2805 0.2820 0.2816

20 1.3010 0.5544 0.5575 0.5514 0.5035 0.5076 0.5034

25 1.3979 0.7036 0.7064 0.7015 0.6740 0.6747 0.6685

30 1.4771 0.8323 0.8327 0.8313 0.8108 0.8126 0.8058

35 1.5441 1.0820 1.0972 1.0992 0.8533 0.8558 0.8480

0 1.6021 1.3082 1.3251 1.3192 1.2309 1.2244 1.2268

50 1.6990 1.4936 1.4969 1.4969 1.4610 1.4547 1.4557!0 1.7782 1.6580 1.6566 1.6593 1.6316 1.6306 1.6299

k 1.7837795466 1.787908072 1.8122399689 1.535308299 1.5203659137 1.52369312

r 0.9813920447 0.981152712 0.9822368712 0.953592618 0.9531693874 0.951981308

0.9631303453 0.962660645 0.9647892711 0.909338881 0.908531881 0.906268411

&aktu('nit)

&aktu('nit)

r,


18/22

FormulaKorsmr-ppas

k *+ *+ n *+

F1 1.7946 0.0154 0.9635 0.0011 1.8083 0.0154

F2 1.5265 0.0078 0.9080 0.0016 1.7534 0.0078

Konsntrasi bat .iap &aktu (mt)

C00

F1 F2

R1 R2 R3 R1 R2 R3

5 0.5424 0.5471 0.5158 0.8042 0.8323 0.8211

10 1.4156 1.4130 1.3698 1.9077 1.9141 1.9124

15 2.4327 2.4351 2.3867 3.1876 3.2181 3.1874

20 3.5839 3.6099 3.5600 4.7206 4.7279 4.6608

25 5.0534 5.0859 5.0287 6.4683 6.4950 6.3948

30 6.7966 6.8035 6.7816 7.1327 7.1753 7.0467

35 12.0792 12.5075 12.5651 17.0163 16.7643 16.8572

0 20.3353 21.1398 20.8534 28.9037 28.4883 28.553350 31.1585 31.3997 31.4014 42.8143 42.7215 42.6445

!0 45.4948 45.3533 45.6388 58.1440 57.6749 57.8408

nntuan 4ilai ksponn lpasan

F1

r,

&aktu('nit)


19/22

$o" t R1 R2 R3

mt#m lo" (mt#m) mt#m lo" (mt#m) mt#m lo" (mt#m) mt#m

5 0.6990 0.0005 -3.2657 0.0005 -3.2620 0.0005 -3.2875 0.0008

10 1.0000 0.0014 -2.8491 0.0014 -2.8499 0.0014 -2.8634 0.0019

15 1.1761 0.0024 -2.6139 0.0024 -2.6135 0.0024 -2.6222 0.0032

20 1.3010 0.0036 -2.4456 0.0036 -2.4425 0.0036 -2.4486 0.0047

25 1.3979 0.0051 -2.2964 0.0051 -2.2936 0.0050 -2.2985 0.006530 1.4771 0.0068 -2.1677 0.0068 -2.1673 0.0068 -2.1687 0.0071

35 1.5441 0.0121 -1.9180 0.0125 -1.9028 0.0126 -1.9008 0.0170

0 1.6021 0.0203 -1.6918 0.0211 -1.6749 0.0209 -1.6808 0.0289

50 1.6990 0.0312 -1.5064 0.0314 -1.5031 0.0314 -1.5031 0.0428

!0 1.7782 0.0455 -1.3420 0.0454 -1.3434 0.0456 -1.3407 0.0581

n 1.797146964 1.8019470855 1.8258385955 1.761

e(aa 1.8083108817

('nit)


20/22


21/22

F2


22/22

R1 R2 R3

lo" (mt#m) mt#m lo" (mt#m) mt#m lo" (mt#m)

-3.0946 0.0008 -3.0797 0.0008 -3.0856

-2.7195 0.0019 -2.7180 0.0019 -2.7184

-2.4965 0.0032 -2.4924 0.0032 -2.4966

-2.3260 0.0047 -2.3253 0.0047 -2.3315

-2.1892 0.0065 -2.1874 0.0064 -2.1942-2.1467 0.0072 -2.1442 0.0070 -2.1520

-1.7691 0.0168 -1.7756 0.0169 -1.7732

-1.5390 0.0285 -1.5453 0.0286 -1.5443

-1.3684 0.0427 -1.3694 0.0426 -1.3701

-1.2355 0.0577 -1.2390 0.0578 -1.2378

847067 1.7466201035 1.7517244988

1.753443103

data uji pelepasan obat - suppositoria asam salisilat (1)

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