date prepared: july 8, 2021
TRANSCRIPT
Curriculum Vitae Lance L. Munn, PhD
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Date Prepared: July8,2021
Name: LanceL.Munn
Education 1987 B.S.
summacumlaudeChemicalEngineering Universityof
Cincinnati1993 Ph.D. ChemicalEngineering&Bioengineering
(Advisor:K.Zygourakis)RiceUniversity
Industry Experience 1984-1986 Co-opEngineer Photolithography/Inkformulation Diconix,Inc. (Kodak)Dayton,OH
Postdoctoral Training 06/93-03/96 PostdoctoralFellow BloodRheology&LeukocyteTrafficking
(Advisors:R.Melder,R.K.Jain)MassachusettsGeneralHospital
Faculty Academic Appointments 1996-1998 Instructor RadiationOncology HarvardMedicalSchool1999-2004 AssistantProfessor RadiationOncology HarvardMedicalSchool2004-present AssociateProfessor RadiationOncology HarvardMedicalSchool
Appointments at Hospitals/Affiliated Institutions 1988-1993 Asst.Fellowof
ImmunologyImmunology M.D.AndersonCancerCenter
1993-1996 ResearchFellow RadiationOncology MassachusettsGeneralHospital2004-2016 AssociateBiologist RadiationOncology MassachusettsGeneralHospital2016-present Investigator MGHResearchInstitute MassachusettsGeneralHospital
Major Administrative Leadership Positions
Local
1995-present Director,Bioengineering,Imaging,andComputingCore,SteeleLaboratories
MassachusettsGeneralHospital
2010-present DeputyDirector SteeleLaboratories,MGH2017 Co-chairandorganizer 2017BostonAngiogenesisMeeting
StarrCenter,Boston
Regional
2006-present ProgramSteeringCommitteeMember CityCollegeNewYork/MemorialSloanKetteringCancerCenterPartnershipforCancerResearch,TrainingandCommunityOutreach
Curriculum Vitae Lance L. Munn, PhD
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National and International
2012-2014 ExpertPanelist AssessmentofPhysicalSciencesandEngineeringAdvancesinLifeSciencesandOncology(APHELION)inEuropeNCI,OfficeofPhysicalSciencesOncology
2012 Co-ChairandOrganizer USNationalCommitteeonBiomechanics4thSymposiumonFrontiersinBiomechanics:“MechanicsinOncology”
2014 Co-ChairandOrganizer MathematicalBiosciencesInstituteWorkshoponMetastasisandAngiogenesis,OhioStateUniversity
2018 Co-Chair 8thWorldCongressofBiomechanics,Dublin,Ireland
2019-present SABmember SimBioSys,Inc.2020-present ExternalScientificAdvisoryBoard
member CenterforCancerEngineering,TheOhioStateUniversity
2021 Chair,LymphaticModeling LymphaticForum2021
Committee Service
Local
1993-present CandidateSearchCommittee SteeleLaboratories,MGH 1993-96 Chair2016-present Co-Organizer,MGHsite HarvardMedicalSchoolVascularBiology
SeminarSeries
National and International
2013 Thesiscommitteemember Univ.Waterloo,MadjidSoltanidissertation2013 President,thesiscommittee InstitutCurie,KevinAlessandridissertation2016 Externalthesiscommitteemember McGillUniversity,S.Ghaffaridissertation
Professional Societies 1993-present AmericanInstituteofChemicalEngineers 1999–2008 sessionchair2001-present BiomedicalEngineeringSociety 2000-2005 sessionchair2002-present AmericanAssociationforCancerResearch 2002-present RadiationResearchSociety 2010-present MicrocirculatorySociety 2009-present NorthAmericanVascularBiologyAssociation 2017-present AmericanAssociationfortheAdvancement
ofScience
Curriculum Vitae Lance L. Munn, PhD
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Grant Review Activities
6/7/00 TransfusionMedicine NIH(NHLBI)AdhocMember
3/23/01 OncologicalSciencesRev.Committee NIH(NCI)AdhocMember
6/2/04-6/10/04 FastLanereviewsystem NationalScienceFoundationAdhocMember
3/9/05 MicroscopicImagingStudySection NIHAdhocMember
10/12–10/13/06 TumorMicroenvironment NIH(NCI)AdhocMember
6/4-6/6/07 Modeling&AnalysisofBiologicalSystems NIHAdhocMember
2010-present SystemsBiology,ZRG1VH-D(55) NIH(NHLBI)Member
1/11-3/12 VascularHematologySEP NIHAdhocMember
3/18/14 SEP/ScientificReviewGroupZEB1OSR-C(M3)Reviewpanel
NIH(NIBIB)AdhocMember
11/19/2015 SEP/ScientificReviewGroup2016/01ZCA1TCRB-T(J2)Reviewpanel
NIH(NCI)AdhocMember
4/14/2016 PhysicalSciencesOncologyCenters(U54)Reviewpanel
NIH(NCI)AdhocMember
2014-present ResearchCouncilKULeuven UniversityofLeuven,BelgiumReviewer
2016-present ResearchGrantsCouncil(RGC)ofHongKong
UniversityGrantsCommitteeReviewer
2/19-2/202019 DrugDiscoveryandMolecularPharmacologyStudySection
NIH(NCI)Ad hoc Member
2019-present ITMOCanceroftheFrenchNationalAllianceforLifeandHealthSciences
Inserm,Reviewer
2/19/2020 HypertensionandMicrovasculature NIH(NHLBI)AdhocMember
Editorial Activities (reviewer)
AmericanJournalofPhysiology LabonaChipAnalyticalChemistry LancetOncologyAnnalsofBiomedicalEngineering MicrocirculationBiorheology MicrovascularResearchBiotechniques NatureCellBiologyCancerCell NatureMethods
Curriculum Vitae Lance L. Munn, PhD
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CancerResearch PhysicalReviewLettersIntegrativeBiology PLoSComputationalBiologyJournalofTheoreticalBiology PNAS
Other Editorial Roles 2015-present GuestEditor PNAS2017-present Editor Microcirculation
Honors and Prizes 1987 EngineeringHonorSociety,
TauBetaPiUniversityofCincinnati
1989 CoxFellowship RiceUniversity 1991 PhillipsAwardforPre-
doctoralResearchRiceUniversity
1995 Postdoctoraltraininggrant NIH 2000 LJISTravelAward WhitakerFoundation 2006 Outstandingcoverdesign Taylor&FrancisGroup,
ComputationalandMathematicalMethodsinMedicine
Scientificillustrationforjournalcover
2013 GerritsenAward MicrocirculatorySociety Mostcitedjournalarticle2014 GerritsenAward MicrocirculatorySociety Mostcitedjournalarticle2015 DistinguishedAlumnus
AwardRiceUniversity
2016-present MemberoftheCollegeofFellows
AmericanInstituteforMedicalandBiologicalEngineering
2018 UniversityDelegate,InaugurationofHarvardPresident
RiceUniversity
2020 Top1%compositecitationindex
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000918
Formally Supervised Trainees
1996—1998 Hera Lichtenbeld, PhD/Currently:ProjectManagement,PharmaCell,Maastricht,NetherlandsPostdoctoral,Projecttitle:“VascularPermeabilityofIndividualMicrovessels”Published one paper.
1997—2000 Jin Yuan, PhD/Currently:SeniorResearchScientistatGenoceaBiosciencesPostdoctoral, Project title: “Fluid Dynamics and Leukocyte Adhesion” Published three papers.
Curriculum Vitae Lance L. Munn, PhD
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2001-2002 Cristina Sousa/ Doctoral, Project title: “TraffickingofLymphocytesandMetastaticCancerCells”
1998–1999 Gerald Koenig, MD, PhD/Currently:Cardiologist,HenryFordWestBloomfieldHospital,MIPostdoctoral,Projecttitle:“BiophysicsofLymphocyteAdhesioninTumors”Publishedonemanuscript,grantedF32Fellowship,co-authoredpatent.
1998—2000 Yong Chang, PhD/Currently:VicePresidentatIntelliaTherapeutics,Inc.Postdoctoral,Projecttitle:“HydraulicConductivityandPermeabilityofEndothelialMonolayers”Publishedthreepapers,oneinPNAS.
1998—2000 Randall Dull, MD, PhD/Currently:PresidentialEndowedChairinAnesthesiology,Director,LungVascularBiologyLaboratory,AssociateProfessor,Bioengineering,UniversityofUtahPostdoctoral,Projecttitle:“PlGF-VEGFSynergyinEndothelialResponses”Publishedtwopapers.
1998—2001 Emmanuelle di Tomaso, PhD/Currently:VicePresident,TranslationalMedicine,SyrosPharmaceuticals,CambridgeMAPostdoctoral,Projecttitle:“PermeabilityofBrainTumorVasculature”Publishedfourpapers,oneinCancerResearchandoneinPNAS;receivedClaflinDistinguishedScholarAward,andMartinPrize
2000—2001 Cristiano Migliorini, PhD/Currently:ExecutiveDirectoratBankVontobelAG,Geneva,SwitzerlandPostdoctoral,Projecttitle:“ModelingFluidDynamicsandLeukocyteAdhesion”Publishedthreepapers.
2000-2002 RobertCampbell,PhD/Currently:AssociateProfessor,MassachusettsCollegeofPharmacyandHealthSciencesPostdoctoral,Projecttitle:“DeliveryofLiposomestoTumorVessels”Publishedonepaper,CancerResearch.
2000-2003 Maximilian Bockhorn, MD, PhD/Currently:Surgeon,DepartmentofGeneral&TransplantSurgery;UniversityHospital,Essen,GermanyPostdoctoral,Projecttitle:“AnalysisofCancerCellsShedfromaSolidTumor”Publishedtwopapers,LancetOncologyandCancerResearch.
2000-2003 Neil Forbes, PhD/Currently:Professor,U.MassachusettsAmherstPostdoctoral,Projecttitle:“TreatingTumorswithPenetratingBacteria”Publishedonepaper,CancerResearch.
2002-2006 Chenghai Sun, PhD/Currently:Sr.ResearchScientist,ExaCorp.,Burlington,MAPostdoctoral,Projecttitle:“Lattice-BoltzmannModelingofHemodynamics”Publishedfivepapers,twoinBiophysicalJournal.
2003-2007 Aaron Mulivor, PhD/Currently:SeniorAssociate,Pharma&LifeSciencesAdvisoryatPwCPostdoctoral,Projecttitle:“BloodDynamicsandAtherosclerosis”
2004-2008 Michael Dupin, PhD/Currently:DirectorofPPNRAnalytics,SVPatCitizensBank,Boston,MAPostdoctoral,Projecttitle:“3DSimulationofBloodRheology”Publishedthreepapers.
2004-2010 Janet Tse/ Currently:PatentAgent,NixonPeabodyLLP,BostonDoctoral,Projecttitle:“TumorSolidStress”Published1paper,PNAS.
Curriculum Vitae Lance L. Munn, PhD
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2005-2009 Gang Cheng, PhD/Currently:HeadofScientificLiaisonatRocheChinaPostdoctoral,Projecttitle:“CellularmechanismsofAngiogenesis”Published2papers,oneinBlood.
2006-2009 James Alex Tyrrell, PhD/Currently:VicePresident,PlatformSearchCapabilityatThomsonReutersPostdoctoral,Projecttitle:“QuantitativeImageAnalysisofVascularNetworks”Publishedthreepapers.Co-authoredsuccessfulR01application(R01CA149285).
2006-2011 Delphine Lacorre, PhD / Currently: Research Engineer, Lille, France Postdoctoral,Projecttitle:“EffectsofVascularNormalizationonDrugDelivery”Publishedtwopapers;receivedKomenFellowship.
2006-2011 Walid Kamoun, PhD/Currently:AssociateDirector-ResearchTeamLeader,MerrimackPharmaceuticalsPostdoctoral,Projecttitle:“BloodFlowDistributioninTumors”Publishedfivepapers,oneinNatureMethods;receivedKomenFellowship.
2008-2011 Temitope Sodunke, PhD/ Currently:Strategy,Innovation,MedicalDeviceProfessionalatBDPostdoctoral,Projecttitle:“StromalDeterminantsofCancerCellInvasion”ReceivedMerckPostdoctoralFellowship.
2008-2011 Abhishek Jain, PhD/Currently:AssistantProfessor,TexasA&M;Doctoral,Projecttitle:“BloodMicrofluidics”Publishedthreepapers,oneinLabChip
2008-2014 Jonathan Song, PhD /Currently:AssociateProfessor,OhioStateUniversityPostdoctoral,Projecttitle:“Fluidforcescontrolendothelialmorphogenesis”Publishedthreepapers,PNAS,LabChip,IntegrativeBiology
2010-2015 Christian Kunert, PhD/ Currently:Amgen,Cambridge,MAPostdoctoral,Projecttitle:“Mechanobiologyoflymphatictransport”ReceivedDFGFellowship;publicationinPNAS
2011-2015 Gabriel Gruionu, PhD/ Currently:Instructor,MassachusettsGeneralHospitalPostdoctoral,Projecttitle:“Determinantsofvascularremodelingintumors”Published2patentsandonepaper
2011-2016 Despina Bazou, PhDPostdoctoral,Projecttitle:“Endothelialdynamicsandtumortissueengineering”Published5papers
2012-2019 Nir Maimon, PhDPostdoctoral,Projecttitle:“Communicationbetweenbloodvesselcellsintumors”
2014-2019 Hadi Tavakoli Nia, PhD Postdoctoral,Projecttitle:Quantifyingtumormechanopathologies
2017-present Huabing Li, PhDPostdoctoral,Projecttitle:“Lymphaticvalvemechanics”
2018-present Mohammad Reza NikmaneshiDoctoral,Projecttitle:“Tumorengineeringandangiogenesis”
2020-present Mohammad Razavi Postdoctoral,Projecttitle:“Systemsbiologyofanti-cancerimmunity”
Curriculum Vitae Lance L. Munn, PhD
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2020-present Tuoye Xu Postdoctoral,Projecttitle:“Stress-inducedtumorimmunesuppression”
2021-present Meghan O’Melia Postdoctoral,Projecttitle:“Lymphocytetraffickingandcancerimmunology”
Local Invited Presentations No presentations below were sponsored by outside entities
November3,2008 “Multiscaleanalysesofblooddynamics.”MartinosCenterforBiomedicalImaging,NeurovascularSeminarSeries,MGH,Charlestown,MA
October14,2009 “Blooddynamicsandtumormicro-anatomy.”HarvardCatalyst,CenterforNanoscaleSystemsSpecialSeminar:ApplyingNanoscaleTechnologiesinBiomedicalResearch,CambridgeMA.
November5,2010 “Connectionofvascularnetworksviawrapping-and-tappinganastomosis.”BostonAngiogenesisMeeting,MEEI,2010,BostonMA
March8,2011 "Microanatomyandmechanobiology:howthecellmicroenvironmentinfluencescoordinatedmigrationandvascularmorphogenesis."TopicsinBioengineeringSeminarSeries,HarvardSchoolofEngineeringandAppliedSciences(SEAS),Cambridge,MA.
April21,2013 “MechanobiologyofVascularDynamics.”MechanicalForcesinDevelopmentmeeting,TuftsMedicalSchool,Boston
November7,2013 “Biomechanicalcontrolofvesselmorphogenesis,adaptationandfunction.”BostonAngiogenesisMeeting,MEEI,2013,BostonMA
March8,2013 “VascularBiologyandMechanobiology.”MGHT32LectureSeriesNovember4,2015 “Untanglingtumorvasculature.”BostonAngiogenesisMeeting,MEEI,2015,BostonMANovember9,2020 “PhysicalTraitsofCancer.”LudwigCenter,HarvardMedicalSchoolJanuary26,2021 “SystemsBiologyModelingofCOVID-19.” NanomedicineAcademyatNortheastern
UniversityLectureSeries
Report of Regional, National and International Invited Teaching and Presentations Thosepresentationsbelowsponsoredbyoutsideentitiesaresonotedandthesponsorisidentified.
Invited Presentations and Courses
Regional
March31,2009 “Multi-scaleAnalysesoftumorphysiologyandbloodvesseldynamics.”2009SeminarSeries,CenterforFluidDynamics,BrownUniversity,Providence,RI.
National
July23-28,1995 “TheRoleofErythrocytesinLeukocyte-EndothelialInteractions.”AnnualConferenceonBiorheologyandClinicalHemorheology,BigSky,MT.
October4-6,1996 “QuantificationofMetastaticCellArrest,Extravasation,andColonization.”AnnualMeetingoftheBiomedicalEngineeringSociety,PennStateUniversity.
June4,1999 "MolecularDeterminantsofTumorPathophysiology."AmericanAssociationofClinicalChemistryMeeting,Boston,MA
Curriculum Vitae Lance L. Munn, PhD
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June25-26,1999 “TransvascularTransportinTumors.”8thAnnualWorkshoponAdvancedMethodsofPharmacokineticandPharmacodynamicSystemsAnalysis,LosAngeles,CA.
Jan11-15,2000 "VisualizationandQuantificationofGeneFunctioninVivo.”QuantitativeChallengesinthePost-genomicSequenceEra:AWorkshopandSymposium,SanDiego,CA
January19,2001 “TumorAngiogenesisattheCellularLevel.”(MayoClinic)MayoClinicGoldmanSymposiumonInnovativeResearchinMultipleMyeloma,AmeliaIsland,FL
April29,2001 “VascularDevelopmentandAnti-angiogenicStrategies.”PediatricAcademicSocieties’2001AnnualMeeting,Baltimore,MD
November8,2001 “Modelingleukocyteadhesioninsmallvessels:aLatticeBoltzmannapproach.”PlenaryTalk(selectedabstract),AmericanInstituteofChemicalEngineeringAnnualMeeting,Reno,NV
September6-8,2002
“TumorPhysicsandBiology:ImpactofAberrantVascularArchitectureonTherapy.”ThirdAnnualBioMEMs&BiomedicalNanotechnologyWorld2002Columbus,OH
October25,2002 “InfluenceofVesselGeometryonLeukocyteAdhesion:aLattice-BoltzmannModel.”AnnualMeetingoftheBiomedicalEngineeringSociety,Houston,TX.
February27,2003 “TumorVesselAbnormalitiesandLeukocyte-ErythrocyteDynamics.”PennStateUniversity,StateCollege,PA
November11,2004 “Microfluidicdeviceforauto-separationofwhitebloodcellsfromwholeblood.”PlenaryTalk(selectedabstract),AmericanInstituteofChemicalEngineeringAnnualMeeting,Austin,TX
December1,2004 “Reverseengineeringofbloodcelldynamics.”CityCollegeofNewYork,Fall2004SeminarSeries,DepartmentofBiomedicalEngineering
February17-21,2005
“TheTumorMicroenvironment:ModelingandExperimentalValidation.“MathematicalOncology:BridgingtheScientificDivide,AAASAnnualMeeting,WashingtonDC
May10,2005 “BiomimeticDesignofaMicrofluidicDeviceforAuto-separationofLeukocytesfromWholeBlood.”NSTINanotechnologyConference,AnaheimCA
December18-19,2006
“Microfluidicsandparticletransportintumors.”FineParticleSocietyNanotechnologyinLifeSciencesSymposium,SanDiego,CA
December18-21,2006
“BiomimeticDesignofaMicrofluidicDeviceforAuto-separationofLeukocytesfromWholeBlood.”SymposiumonNanotechnologyinLifeSciences20thInternationalConferenceonBioandPharmaceuticalScienceandTechnology,SanDiego,CA
October2-4,2008 “IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,StLouis,MA
October26-28,2008
“IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”NCIInnovativeMolecularAnalysisTechnologies(IMAT)program,Cambridge,MA
November30,2008 “IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”MaterialsResearchSociety:CancerNanotechnologyMedSchool–RealWorldChallengesandNano’sStrengthsinCancerPrevention,Diagnosis,andTreatment,Boston,MA
January26-30,2009
“Multi-scaletumorphysiologyandbloodvesseldynamics.”MathematicalBiosciencesInstituteWorkshoponCancerDevelopment,Angiogenesis,ProgressionandInvasion,Columbus,OH
October8,2009 “Tumorbloodvesseldynamics.”QuantitativePharmacologyTechnicalSummit(EliLilly),Indianapolis,IN
October7-10,2009 “Tumorbloodvesseldynamics.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,Pittsburgh,PA
November23,2009 “Tumorbloodvesseldynamics.”62ndAnnualMeetingoftheAPSDivisionofFluidDynamics,Minneapolis,Minnesota
Curriculum Vitae Lance L. Munn, PhD
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April24-28,2010 “Wrapping-and-tappinganastomosisbetweenengraftedendothelialnetworksandhostvasculature.”PlenaryTalk(selectedabstract),ExperimentalBiologyMeeting,Anaheim,CA
October6-8,2010 “Wrapping-and-tappinganastomosisbetweenengraftedendothelialnetworksandhostvasculature.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,Austin,MA
November1-2,2010 “Compression-inducedcancercellinvasion:don’tpushme‘causeI’mclosetotheedge.”UCSD/NSFPhysicsofCancerMetastasisMeetingArlington,VA
April3-6,2011 “Tumorvesseldynamicsduringanti-angiogenictherapy.”AmericanConferenceonPharmacometrics,SanDiego,CA
Aug30-Sept3,2011 “Cell-MatrixInteractionswithinTumorsandNormalTissue.”33rdAnnualInternationalConferenceoftheIEEEEngineeringinMedicineandBiologySocietyBoston,MA
March7,2011 “Tumorbloodvesseldynamics.”PhysicalSciences–OncologyCenterSteeringCommitteemeeting
October28,2011 "Imagingvasculardynamics"MultiscaleSystemsBiologyworkinggroupoftheMultiscaleModeling(MSM)Consortium
October24,2012 “SolidandFluidBiomechanicsintheTumorEnvironment”.USNationalCommitteeonBiomechanics4thSymposiumonFrontiersinBiomechanics:MechanicsinOncology
April2,2013 “MechanobiologyandVascularDynamics,”IMESeminarSeries,UniversityofPennsylvania
September27,2013 "Biomechanicaldeterminantsofcellinvasion,angiogenesisandlymphaticfunction."CusterWorkplaceLectureSeries,UniversityofWesternMichigan
October15,2014 “Biomechanicsofcancerinvasionandvesselfunction.”MathematicalBiosciencesInstituteWorkshoponMetastasisandAngiogenesis,Columbus,OH.
April3,2015 “Deconvolvingtumordynamics.”DepartmentofMechanicalandAerospaceEngineeringSeminarSeries,OhioStateUniversity
March29,2016 “Deconvolvingtumordynamics.”RiceUniversity'sBioengineeringColloquiumOctober27,2016 “SystemsBiologyofLymphTransport.” NHLBISystemsBiologymeeting,Bethesda,MD. April10,2018 “TumorEngineeringandMechanobiology.”DepartmentofChemicalandBiomolecular
EngineeringSeminarSeries,OhioStateUniversitySeptember7,2018 “Engineeredtumorsforpersonalizedmedicine.”DukeUniversityLectureSeries,Durham,
NCMarch5,2019 “Reverseengineeringtumorsandvasculature.”(Keynote)UniversityofNorthCarolina
IntegrativeVascularBiologyresearchsymposium.ChapelHill,NCSeptember12,2019 “Mechanobiologicalcontrolofvascularfunction.”AmericanPhysiologicalSociety
meeting,Interfaceofmathematicalmodelsandexperimentalbiology:Roleofmicrovasculature.Scottsdale,AZ
January20,2020 “ReengineeringthePhysicalMicroenvironmentofTumorstoImproveTreatmentResponse”CambridgeHealthtechInstitute;EngineeringNextGenerationCancerImmunotherapies;Partofthe19thAnnualPepTalk,SanDiego,CA
July20,2020 “OptimizingtreatmentforCOVID-19usingcomputationalmodelling:Implicationsforcancerpatients.”AACRVirtualMeeting:COVID-19andCancer.
International
Curriculum Vitae Lance L. Munn, PhD
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August25-30,1996 “InteractionofActivatedLeukocyteswithTumorVessels.”SixthWorldCongressforMicrocirculation,Munich,Germany
October3-7,1998 “TumorAngiogenesisandMicrocirculation.”10thAnnualConferenceoftheInternationalSocietyofDifferentiation,Houston,TX
Oct22-25,1999 “TumorAngiogenesis.”ConferenceonAngiogenesisandTumors,Paris,FranceOct12-15,2002 “TumorVesselAbnormalities.”SecondInterdisciplinaryEuroconferenceonAngiogenesis,
Cascals,PortugalApril23-24,2004 “Theinteractionofcirculatingcellswithtumors:pharmacokineticandfluiddynamic
models.”WorkshoponMathematicalOncology,TheFieldsInstitute,Toronto,ON August1,2006 “Tumorvesselabnormalitiesaffectbloodcelldynamicsandflowdistribution.” Cancerand
Bioengineering;WorldCongressofBiomechanics,MunichGermanyJuly2-4,2008 “Multi-scaleanalysesoftumorphysiologyandbloodvesseldynamics.”FieldsInstitute
WorkshoponGrowthandControlofTumors:TheoryandExperimentToronto,CAJuly9-13,2008 “Blooddynamicsinnormalandabnormalvesselnetworks.”InternationalCongressof
Biorheology,PennStateUniversity,StateCollege,PAJanuary4-7,2010 “ModelingTumorbloodvesseldynamics.”WorkshoponMathematicalMethodsin
SystemsBiology,TelAviv,IsraelMarch18-20,2010 “ModelingTumorbloodvesseldynamics.”FieldsInstituteWorkshoponMathematical
OncologyToronto,CAMay10-12,2010 “ModelingTumorbloodvesseldynamics.”CentreEuropeandeCalculAtomiqueet
Moleculaire(CECAM)WorkshoponTrendsinComputationalHemodynamics,Lausanne,Switzerland
Sept.17-20,2011 “Vasculardynamicsandanti-angiogenictherapy.”Tumor-VesselInterfacemeeting,KlosterSeeonGermany
March28-30,2011 “Targetingvasculardynamics.”VIIthAcademicianNicolaeCajalSymposium,Bucharest,Romania
December3,2013 “Biomechanicaldeterminantsofmorphogenesisandvascularfunction”InstitutCurie,ParisFrance
May29-30,2014 “Microsystemsforprobingblood,vesselandtumordynamics.”(Keynote)Ontario-on-a-ChipConference,UniversityofToronto,Toronto,CA
July6-11,2014 “BiomechanicalControlofVesselMorphogenesis,AdaptationandFunction.”SeventhWorldCongressofBiomechanics,Boston,MA
July6-11,2014 “Biomechanicalautoregulationoflymphatictransport.”SeventhWorldCongressofBiomechanics,Boston,MA
October2-8,2014 "Biomechanicalprocessesandtopologicaldynamicsintumors"AnnualSymposiumofPhysicsofCancer,UniversityofLeipzig
June25-28,2016 "Visualizingcellandmatrixdynamicsintumors"AACRSpecialConferenceonEngineeringandPhysicalSciencesinOncology,WestinBostonWaterfront,Boston,MA
February5-9,2017 “Tumorsolidstressandmechanobiology”PhysicalScienceofCancerGordonResearchConference,Galveston,TX
Dec.7-10,2017 “Acceleratingrevascularization.”InnovationsinWoundHealingConference,Bimini,Bahamas.
July10,2018 “Leaky Blood Vessels, GAGs and Metastasis” World Congress of Biomechanics 2018, Dublin, Ireland
June1,2020 Keynote talk, “Physical Hallmarks of Cancer,” Third Workshop on Hallmarks in cancer and the development of diagnostic tools, Porto, Portugal. [Cancelled due to COVID-19 pandemic]
Curriculum Vitae Lance L. Munn, PhD
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Report of Scholarship Publications
Peer reviewed publications in print or other media [more than 15,000 citations; h-index= 63 (Web of Science); 67 (Google Scholar)]
Research Investigations 1. MunnLL,GlackenMW,McintyreBW,ZygourakisK.Analysisoflymphocyteaggregationusingdigital
imageanalysis.JImmunolMethods.1993;166:11-25.2. TeagueTK,MunnL,ZygourakisK,McintyreBW.Analysisoflymphocyteactivationandproliferationby
videomicroscopyanddigitalimaging.Cytometry.1993;14:772-82.3. MunnLL,MelderRJ,JainRK.Analysisofcellfluxintheparallelplateflowchamber:implicationsforcell
capturestudies.BiophysJ.1994;67:889-95.4. MelderRJ,MunnLL,YamadaS,OhkuboC,JainRK.Selectin-andintegrin-mediatedT-lymphocyterolling
andarrestonTNF-alpha-activatedendothelium:augmentationbyerythrocytes.BiophysJ.1995;69:2131-8.
5. MunnLL,KoenigGC,JainRK,MelderRJ.Kineticsofadhesionmoleculeexpressionandspatialorganizationusingtargetedsamplingfluorometry.Biotechniques.1995;19:622-6,628-31.
6. MelderRJ,KoenigGC,MunnLL,JainRK.Adhesionofactivatednaturalkillercellstotumornecrosisfactor-alpha-treatedendotheliumunderphysiologicalflowconditions.NatImmun.1996a;15:154-63.
7. MelderRJ,KoenigGC,WitwerBP,SafabakhshN,MunnLL,JainRK.Duringangiogenesis,vascularendothelialgrowthfactorandbasicfibroblastgrowthfactorregulatenaturalkillercelladhesiontotumorendothelium.NatMed.1996b;2:992-7.
8. MunnLL,MelderRJ,JainRK.Roleoferythrocytesinleukocyte-endothelialinteractions:mathematicalmodelandexperimentalvalidation.BiophysJ.1996;71:466-78.
9. PatanS,MunnLL,JainRK.Intussusceptivemicrovasculargrowthinahumancolonadenocarcinomaxenograft:anovelmechanismoftumorangiogenesis.MicrovascRes.1996;51:260-72.
10. NeelameghamS,MunnLL,ZygourakisK.Amodelforthekineticsofhomotypiccellularaggregationunderstaticconditions.BiophysJ.1997;72:51-64.
11. ShiodaT,MunnLL,FennerMH,JainRK,IsselbacherKJ.Earlyeventsofmetastasisinthemicrocirculationinvolvechangesingeneexpressionofcancercells.TrackingmRNAlevelsofmetastasizingcancercellsinthechickembryochorioallantoicmembrane.AmJPathol.1997;150:2099-112.
12. LichtenbeldHC,FerarraN,JainRK,MunnLL.Effectoflocalanti-VEGFantibodytreatmentontumormicrovesselpermeability.MicrovascRes1999;57:357-62.
13. ChangYS,diTomasoE,McDonaldDM,JonesR,JainRK,MunnLL.Mosaicbloodvesselsintumors:frequencyofcancercellsincontactwithflowingblood.ProcNatlAcadSciUSA.2000a;97:14608-13.
14. ChangYS,MunnLL,HillsleyMV,DullRO,YuanJ,LakshminarayananS,GardnerTW,JainRK,TarbellJM.Effectofvascularendothelialgrowthfactoronculturedendothelialcellmonolayertransportproperties.MicrovascRes.2000b;59:265-77.
15. MelderRJ,YuanJ,MunnLL,JainRK.Erythrocytesenhancelymphocyterollingandarrestinvivo.MicrovascRes.2000;59:316-22.
16. DaviesCdeL,MelderRJ,MunnLL,Mouta-CarreiraC,JainRK,BoucherY.Decorininhibitsendothelialmigrationandtube-likestructureformation:roleofthrombospondin-1.MicrovascRes.2001;62:26-42.
17. DullRO,YuanJ,ChangYS,TarbellJ,JainRK,MunnLL.Kineticsofplacentagrowthfactor/vascularendothelialgrowthfactorsynergyinendothelialhydraulicconductivityandproliferation.MicrovascRes.2001;61:203-10.
18. MelderRJ,KristensenCA,MunnLL,JainRK.ModulationofA-NKcellrigidity:Invitrocharacterizationandinvivoimplicationsforcelldelivery.Biorheology.2001;38:151-9.
19. PatanS,MunnLL,TandaS,RobergeS,JainRK,JonesRC.Vascularmorphogenesisandremodelinginamodeloftissuerepair:bloodvesselformationandgrowthintheovarianpedicleafterovariectomy.CircRes.2001a;89:723-31.
Curriculum Vitae Lance L. Munn, PhD
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20. PatanS,TandaS,RobergeS,JonesRC,JainRK,MunnLL.Vascularmorphogenesisandremodelinginahumantumorxenograft:bloodvesselformationandgrowthafterovariectomyandtumorimplantation.CircRes.2001b;89:732-9.
21. YuanJ,MelderRJ,JainRK,MunnLL.Lateralviewflowsystemforstudiesofcelladhesionanddeformationunderflowconditions.Biotechniques.2001;30:388-94.
22. CampbellRB,FukumuraD,BrownEB,MazzolaLM,IzumiY,JainRK,TorchilinVP,MunnLL.Cationicchargedeterminesthedistributionofliposomesbetweenthevascularandextravascularcompartmentsoftumors.CancerRes.2002;62:6831-6.
23. FriedrichSW,LinSC,StollBR,BaxterLT,MunnLL,JainRK.Antibody-directedeffectorcelltherapyoftumors:analysisandoptimizationusingaphysiologicallybasedpharmacokineticmodel.Neoplasia.2002;4:449-63.
24. KoikeC,MckeeTD,PluenA,RamanujanS,BurtonK,MunnLL,BoucherY,JainRK.Solidstressfacilitatesspheroidformation:potentialinvolvementofhyaluronan.BrJCancer.2002;86:947-53.
25. MelderRJ,MunnLL,StollBR,MarecosEM,BaxterLT,WeisslederR,JainRK.Systemicdistributionandtumorlocalizationofadoptivelytransferredlymphocytesinmice:comparisonwithphysiologicallybasedpharmacokineticmodel.Neoplasia.2002;4:3-8.
26. MiglioriniC,QianY,ChenH,BrownEB,JainRK,MunnLL.Redbloodcellsaugmentleukocyterollinginavirtualbloodvessel.BiophysJ.2002;83:1834-41.
27. PaderaTP,KadambiA,diTomasoE,CarreiraCM,BrownEB,BoucherY,ChoiNC,MathisenD,WainJ,MarkEJ,MunnLL,JainRK.Lymphaticmetastasisintheabsenceoffunctionalintratumorlymphatics.Science.2002;296:1883-6.
28. ForbesNS,MunnLL,FukumuraD,JainRK.SparseinitialentrapmentofsystemicallyinjectedSalmonellatyphimuriumleadstoheterogeneousaccumulationwithintumors.CancerRes.2003;63:5188-93.
29. FriedrichEB,TagerAM,LiuE,PetterssonA,OwmanC,MunnL,LusterAD,GersztenRE.MechanismsofleukotrieneB4--triggeredmonocyteadhesion.ArteriosclerThrombVascBiol.2003;23:1761-7.
30. RooseT,NettiPA,MunnLL,BoucherY,JainRK.Solidstressgeneratedbyspheroidgrowthestimatedusingalinearporoelasticitymodel.MicrovascRes.2003;66:204-12.
31. StollBR,MiglioriniC,KadambiA,MunnLL,JainRK.Amathematicalmodelofthecontributionofendothelialprogenitorcellstoangiogenesisintumors:implicationsforantiangiogenictherapy.Blood.2003;102:2555-61.
32. SunC,MiglioriniC,MunnLL.Redbloodcellsinitiateleukocyterollinginpostcapillaryexpansions:alatticeBoltzmannanalysisBiophysJ.2003;85:208-22.
33. BockhornM,RobergeS,SousaC,JainRK,MunnLL.Differentialgeneexpressioninmetastasizingcellsshedfromkidneytumors.CancerRes.2004;64:2469-73.
34. DudaDG,FukumuraD,MunnLL,BoothMF,BrownEB,HuangP,SeedB,JainRK.Differentialtransplantabilityoftumor-associatedstromalcells.CancerRes.2004;64:5920-4.
35. WillettCG,BoucherY,diTomasoE,DudaDG,MunnLL,TongRT,ChungDC,SahaniDV,KalvaSP,KozinSV,MinoM,CohenKS,ScaddenDT,HartfordAC,FischmanAJ,ClarkJW,RyanDP,ZhuAX,BlaszkowskyLS,ChenHX,ShellitoPC,LauwersGY,JainRK.DirectevidencethattheVEGF-specificantibodybevacizumabhasantivasculareffectsinhumanrectalcancer.NatMed.2004;10:145-7.
36. WinklerF,KozinSV,TongRT,ChaeSS,BoothMF,GarkavtsevI,XuL,HicklinDJ,FukumuraD,diTomasoE,MunnLL,JainRK.KineticsofvascularnormalizationbyVEGFR2blockadegovernsbraintumorresponsetoradiation:roleofoxygenation,angiopoietin-1,andmatrixmetalloproteinases.CancerCell.2004;6:553-63.
37. DemouZN,AwadM,MckeeT,PerentesJY,WangX,MunnLL,JainRK,BoucherY.LackoftelopeptidesinfibrillarcollagenIpromotestheinvasionofametastaticbreasttumorcellline.CancerRes.2005;65:5674-82.
38. diTomasoE,CapenD,HaskellA,HartJ,LogieJJ,JainRK,McDonaldDM,JonesR,MunnLL.Mosaictumorvessels:cellularbasisandultrastructureoffocalregionslackingendothelialcellmarkers.CancerRes.2005;65:5740-9.
39. KashiwagiS,IzumiY,GohongiT,DemouZN,XuL,HuangPL,BuerkDG,MunnLL,JainRK,FukumuraD.NOmediatesmuralcellrecruitmentandvesselmorphogenesisinmurinemelanomasandtissue-engineeredbloodvessels.JClinInvest.2005;115:1816-27.
Curriculum Vitae Lance L. Munn, PhD
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40. ShevkoplyasSS,YoshidaT,MunnLL,BitenskyMW.Biomimeticautoseparationofleukocytesfromwholebloodinamicrofluidicdevice.AnalChem.2005;77:933-7.
41. SunC,MunnLL.Particulatenatureofblooddeterminesmacroscopicrheology:a2-DlatticeBoltzmannanalysis.BiophysJ.2005;88:1635-45.
42. WillettCG,BoucherY,DudaDG,diTomasoE,MunnLL,TongRT,KozinSV,PetitL,JainRK,ChungDC,SahaniDV,KalvaSP,CohenKS,ScaddenDT,FischmanAJ,ClarkJW,RyanDP,ZhuAX,BlaszkowskyLS,ShellitoPC,Mino-KenudsonM,LauwersGY.Surrogatemarkersforantiangiogenictherapyanddose-limitingtoxicitiesforbevacizumabwithradiationandchemotherapy:continuedexperienceofaphaseItrialinrectalcancerpatients.JClinOncol.2005;23:8136-9.
43. JonesR,CapenD,JacobsonM,MunnL.PDGFandmicrovesselwallremodelinginadultratlung:imagingPDGF-AAandPDGF-Ralphamoleculesinprogenitorsmoothmusclecellsdevelopinginexperimentalpulmonaryhypertension.CellTissueRes.2006;326:759-69.
44. DupinMM,HallidayI,CareCM,AlboulL,MunnLL.Modelingtheflowofdensesuspensionsofdeformableparticlesinthreedimensions.PhysRevEStatNonlinSoftMatterPhys.2007;75:066707.
45. JainRK,TongRT,MunnLL.Effectofvascularnormalizationbyantiangiogenictherapyoninterstitialhypertension,peritumoredema,andlymphaticmetastasis:insightsfromamathematicalmodel.CancerRes.2007;67:2729-35.
46. SunC,JainRK,MunnLL.Non-uniformplasmaleakageaffectslocalhematocritandbloodflow:implicationsforinflammationandtumorperfusion.AnnBiomedEng.2007;35:2121-9.
47. JonesRC,CapenDE,CohenKS,MunnLL,JainRK,DudaDG.Aprotocolforphenotypicdetectionandcharacterizationofvascularcellsofdifferentoriginsinalungneovascularizationmodelinrodents.NatProtoc.2008;3:388-97.
48. DupinMM,HallidayI,CareCM,MunnLLEfficiency-oriented,hybridapproachformodelingdeformableparticlesinthreedimensions.ProgressinComputationalFluidDynamics.2008;8109-120
49. MunnLL,DupinMM.Bloodcellinteractionsandsegregationinflow.AnnBiomedEng.2008;36:534-44.50. SunC,MunnLL.LatticeBoltzmannsimulationofbloodflowindigitizedvesselnetworks.ComputMath
Appl.2008;55:1594-1600.51. AuP,TamJ,DudaDG,LinPC,MunnLL,FukumuraD,JainRK.ParadoxicaleffectsofPDGF-BB
overexpressioninendothelialcellsonengineeredbloodvesselsinvivo.AmJPathol.2009;175:294-302.52. ChengG,TseJ,JainRK,MunnLL.Micro-environmentalmechanicalstresscontrolstumorspheroidsize
andmorphologybysuppressingproliferationandinducingapoptosisincancercells.PLoSOne.2009;4:e4632.
53. diTomasoE,LondonN,FujaD,LogieJ,TyrrellJA,KamounW,MunnLL,JainRK.PDGF-Cinducesmaturationofbloodvesselsinamodelofglioblastomaandattenuatestheresponsetoanti-VEGFtreatment.PLoSOne.2009;4:e5123.
54. JainA,MunnLL.Determinantsofleukocytemarginationinrectangularmicrochannels.PLoSOne.2009;4:e7104.
55. KamounWS,LeyCD,FarrarCT,DuyvermanAM,LahdenrantaJ,LacorreDA,BatchelorTT,diTomasoE,DudaDG,MunnLL,FukumuraD,SorensenAG,JainRK.Edemacontrolbycediranib,avascularendothelialgrowthfactorreceptor-targetedkinaseinhibitor,prolongssurvivaldespitepersistentbraintumorgrowthinmice.JClinOncol.2009;27:2542-52.
56. PerentesJY,MckeeTD,LeyCD,MathiewH,DawsonM,PaderaTP,MunnLL,JainRK,BoucherY.Invivoimagingofextracellularmatrixremodelingbytumor-associatedfibroblasts.NatMethods.2009;6:143-5.
57. VakocBJ,LanningRM,TyrrellJA,PaderaTP,BartlettLA,StylianopoulosT,MunnLL,TearneyGJ,FukumuraD,JainRK,BoumaBE.Three-dimensionalmicroscopyofthetumormicroenvironmentinvivousingopticalfrequencydomainimaging.NatMed.2009;15:1219-23.
58. ChaeSS,KamounWS,FarrarCT,KirkpatrickND,NiemeyerE,DeGraafAM,SorensenAG,MunnLL,JainRK,FukumuraD.Angiopoietin-2interfereswithanti-VEGFR2-inducedvesselnormalizationandsurvivalbenefitinmicebearinggliomas.ClinCancerRes.2010;16:3618-27.
59. KamounWS,ChaeSS,LacorreDA,TyrrellJA,MitreM,GillissenMA,FukumuraD,JainRK,MunnLL.SimultaneousmeasurementofRBCvelocity,flux,hematocritandshearrateinvascularnetworks.NatMethods.2010;7:655-60.
Curriculum Vitae Lance L. Munn, PhD
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60. StylianopoulosT,Diop-FrimpongB,MunnLL,JainRK.Diffusionanisotropyincollagengelsandtumors:theeffectoffibernetworkorientation.BiophysJ.2010a;99:3119-28.
61. StylianopoulosT,PohMZ,InsinN,BawendiMG,FukumuraD,MunnLL,JainRK.Diffusionofparticlesintheextracellularmatrix:theeffectofrepulsiveelectrostaticinteractions.BiophysJ.2010b;99:1342-9.
62. BaishJW,StylianopoulosT,LanningRM,KamounWS,FukumuraD,MunnLL,JainRK.Scalingrulesfordiffusivedrugdeliveryintumorandnormaltissues.ProcNatlAcadSciUSA.2011;108:1799-803.
63. ChengG,LiaoS,KitWongH,LacorreDA,diTomasoE,AuP,FukumuraD,JainRK,MunnLL.Engineeredbloodvesselnetworksconnecttohostvasculatureviawrapping-and-tappinganastomosis.Blood.2011;118:4740-9.
64. JainA,MunnLL.Biomimeticpostcapillaryexpansionsforenhancingrarebloodcellseparationonamicrofluidicchip.LabChip.2011;11:2941-7.
65. LiaoS,ChengG,ConnerDA,HuangY,KucherlapatiRS,MunnLL,RuddleNH,JainRK,FukumuraD,PaderaTP.Impairedlymphaticcontractionassociatedwithimmunosuppression.ProcNatlAcadSciUSA.2011;108:18784-9.
66. PerentesJY,KirkpatrickND,NaganoS,SmithEY,ShaverCM,SgroiD,GarkavtsevI,MunnLL,JainRK,BoucherY.Cancercell-associatedMT1-MMPpromotesbloodvesselinvasionanddistantmetastasisintriple-negativemammarytumors.CancerRes.2011;71:4527-38.
67. SongJW,MunnLL.Fluidforcescontrolendothelialsprouting.ProcNatlAcadSciUSA.2011;108:15342-7.
68. HuangY,YuanJ,RighiE,KamounWS,AncukiewiczM,NezivarJ,SantosuossoM,MartinJD,MartinMR,VianelloF,LeblancP,MunnLL,HuangP,DudaDG,FukumuraD,JainRK,PoznanskyMC.Vascularnormalizingdosesofantiangiogenictreatmentreprogramtheimmunosuppressivetumormicroenvironmentandenhanceimmunotherapy.ProcNatlAcadSciUSA.2012;109:17561-6.
69. PlotkinSR,BredellaMA,CaiW,KassarjianA,HarrisGJ,EsparzaS,MerkerVL,MunnLL,MuzikanskyA,AskenaziM,NguyenR,WenzelR,MautnerVF.Quantitativeassessmentofwhole-bodytumorburdeninadultpatientswithneurofibromatosis.PLoSOne.2012;7:e35711.
70. SongJW,BazouD,MunnLL.Anastomosisofendothelialsproutsformsnewvesselsinatissueanalogueofangiogenesis.IntegrBiol(Camb).2012a;4:857-62.
71. SongJW,DaubriacJ,TseJM,BazouD,MunnLL.RhoAmediatesflow-inducedendothelialsproutingina3-Dtissueanalogueofangiogenesis.LabChip.2012b;12:5000-6.
72. StylianopoulosT,MartinJD,ChauhanVP,JainSR,Diop-FrimpongB,BardeesyN,SmithBL,FerroneCR,HornicekFJ,BoucherY,MunnLL,JainRK.Causes,consequences,andremediesforgrowth-inducedsolidstressinmurineandhumantumors.ProcNatlAcadSciUSA.2012;109:15101-8.
73. TseJM,ChengG,TyrrellJA,Wilcox-AdelmanSA,BoucherY,JainRK,MunnLL.Mechanicalcompressiondrivescancercellstowardinvasivephenotype.ProcNatlAcadSciUSA.2012;109:911-6.
74. KirkpatrickND,ChungE,CookDC,HanX,GruionuG,LiaoS,MunnLL,PaderaTP,FukumuraD,JainRK,Video-rateresonantscanningmultiphotonmicroscopy:Anemergingtechniqueforintravitalimagingofthetumormicroenvironment.IntraVital.2012;1:60-68.
75. NiemeyerE,KamounWS,HanH-S,HuangY,BhaumikJ,ChenY,GillisenM,MartinJD,RobergeS,LanningRM,CuiJ,MunnLL,NoceraDC,PaderaT,FukumuraD,JainRK,BawendiMG,DunstJ,DudaDG.Multiphotonmicroscopyandin-situlabelingtechniquesallowdetectionofendogenoushematopoeticstemcellsandmeasurementoffunctionalparametersinthestemcellniche.ONKOLOGIE.2013;36:229-230.
76. Qazi,H,PalominoR,ShiZ-D,MunnLL,TarbellJM.CancerCellGlycocalyxMediatesMechanostransductionandFlow-RegulatedInvasion.Integr.Biol.2013;5:1334-43.
77. MunnLL.Dynamicsoftissuetopologyduringcancerinvasionandmetastasis.PhysicalBiology.2013;10(6):065003(13pp).
78. KunertC,BaishJW,LiaoS,PaderaTP,MunnLL.Mechanobiologicaloscillatorscontrollymphflow.ProcNatlAcadSciUSA.2015; 112:10938-43.
79. KunertC,BaishJW,LiaoS,PaderaTP,MunnLL.Nitricoxideregulateslymphaticcontractions.ProcNatlAcadSciUSA.2016.113:E106.
80. KloepperJ,RiedemannL,AmoozgarZ,SeanoG,SusekK,YuV,DalvieN,AmelungRL,DattaM,SongJW,AskoxylakisV,TaylorJW,Lu-EmersonC,BatistaA,KirkpatrickKD,JungK,SnuderlM,MuzikanskyA,
Curriculum Vitae Lance L. Munn, PhD
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StubenrauchKG,KrieterO,WakimotoH,XuL,MunnLL,DudaDG,FukumuraD,BatchelorTT,JainRK.Ang-2/VEGFbispecificantibodyreprogramsmacrophagesandresidentmicrogliatoanti-tumorphenotypeandprolongsglioblastomasurvival.ProcNatlAcadSciUSA.2016;113:4476-4481
81. GruionuGG,BazouD,MaimonN,Onita-LencoM,GruionuLG,HuangP,MunnLL.ImplantableTissueIsolationChambersforAnalyzingTumorDynamicsInVivo.LabChip.2016;16:1840-51.
82. QaziH,ShiZD,SongJW,CancelLM,HuangP,ZengY,RobergeS,MunnLL*,TarbellJM.*HeparanSulfateProteoglycansMediateRenalCarcinomaMetastasis.InternationalJournalofCancer.2016;139:2791-2801.*Equalcontributions.
83. BazouD,NgMR,SongJW,ChinSM,MaimonN,MunnLL.Flow-inducedHDAC1phosphorylationandnuclearexportinangiogenicsprouting.ScientificReports.2016a;6:34046.
84. BazouD,MaimonN,GruionuG,MunnLL.Self-assemblyofvascularizedtissuetosupporttumorexplantsinvitro.IntegrativeBiology.2016b;8:1301-11.
85. BaishJW,KunertC,PaderaTP,MunnLL.Synchronizationandrandomtriggeringoflymphaticvesselcontractions.PLOSComputationalBiology.2016;12:e1005231.doi:10.1371/journal.pcbi.1005231.
86. NiaHT,LiuH,SeanoG,DattaM,JonesD,RahbariN,IncioJ,ChauhanVP,JungK,MartinJD,AskoxylakisV,PaderaTP,FukumuraD,BoucherY,HornicekFJ,GrodzinskyAJ,BaishJW,MunnLL,JainRK.Solidstressandelasticenergy:newmeasuresoftumormechanopathology.NatureBiomedicalEngineering.2017;1:0004.
87. GuptaN,BadeauxM,LiuY,NaxerovaK,SgroiD,MunnLL,JainRK,GarkavtsevI.Stressgranule-associatedproteinG3BP2regulatesbreasttumorinitiation.ProcNatlAcadSciUSA. 2016;114:1033-1038.doi:10.1073/pnas.1525387114.
88. KozinSV,MaimonN,WangR,GuptaN,MunnLL,JainRK,GarkavtsevI.Secretoryleukocyteproteaseinhibitor(SLPI)asapotentialtargetforinhibitingmetastasisoftriple-negativebreastcancers.Oncotarget.2017;8(65):108292–108302.
89. BazouD,MaimonN,MunnLL,GonzalezI.EffectsofLowIntensityContinuousUltrasound(LICU)onMousePancreaticTumorExplants.Appl.Sci.2017;7(12)1275;doi:10.3390/app7121275.
90. BoutaEM,BlatterC,RuggieriTA,MeijerEFJ,MunnLL,VakocBJ,PaderaTP.Lymphaticfunctionmeasurementsinfluencedbycontrastagentvolumeandbodyposition.2018;JCIInsight.3(2):e96591.
91. JonesD,MeijerEFJ,BlatterC,LiaoS,PereiraER,BoutaEM,JungK,ChinSM,HuangP,MunnLL,VakocBJ,OttoM,PaderaTP.Methicillin-resistantStaphylococcusaureuscausessustainedcollectinglymphaticvesseldysfunction.2018;ScienceTranslationalMedicine.10(424),eaam7964.OI:10.1126/scitranslmed.aam7964.
92. NiaHT,DattaM,SeanoG,Huang,P,MunnLL,JainRK.Quantifyingsolidstressandelasticenergyfromexcisedorinsitutumors.NatureProtocols.2018;13(5)1091-1105.
93. BazouD,MaimonN,GruionuG,GrahovacJ,SeanoG,LiuH,EvansCL,MunnLL.Vascularbedsmaintainpancreatictumorexplantsforexvivodrugscreening.JournalofTissueEngineeringandRegenerativeMedicine.2018;12(1):e318-e322.
94. SeanoG,Nia,HT,EmblemKE,DattaM,RenJ,KrishnanS,KloepperJ,PinhoMC,HoWW,GhoshM,AskoxylakisV,FerraroGB,RiedemannL,GerstnerER,BatchelorTT,WenPY,LinNU,GrodzinskyAJ,FukumuraD,HuangP,BaishJW,PaderaTP,MunnLL,JainRK.Solidstressinbraintumourscausesneuronallossandneurologicaldysfunctionandcanbereversedbylithium.NatureBiomedicalEngineering2019;3:230-245.
95. LiH,MeiY,MaimonN,PaderaTP,BaishJW,MunnLL.Theeffectsofvalveleafletmechanicsonlymphaticpumpingassessedusingnumericalsimulations.ScientificReports2019;9(1):10649.
96. MoranH,CancelLM,MayerMA,QaziH,MunnLL,TarbellJM.Thecancercellglycocalyxproteoglycanglypican-1mediatesinterstitialflowmechanotransductiontoenhancecellmigrationandmetastasis.Biorheology1-11,2019.
97. VoutouriC,KirkpatrickND,ChungE,MpekrisF,BaishJW,MunnLL,FukumuraD,StylianopoulosT,JainRK.Experimentalandcomputationalanalysesrevealdynamicsoftumorvesselcooptionandoptimaltreatmentstrategies.ProceedingsoftheNationalAcademyofSciences,116:2662-2671,2019.
98. MpekrisF,VoutouriC,BaishJW,DudaDG,MunnLL,StylianopoulosT,JainRK.Combiningmicroenvironmentnormalizationstrategiestoimprovecancerimmunotherapy.ProceedingsoftheNationalAcademyofSciences,117:3728-3737,2020.
Curriculum Vitae Lance L. Munn, PhD
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99. NikmaneshiMR,FiroozabadiB,MozafariA,MunnLL.Amulti-scalemodelfordeterminingtheeffectsofpathophysiologyandmetabolicdisordersontumorgrowth.ScientificReports,10(1):3025,2020;doi:10.1038/s41598-020-59658-0.
100. DattaM,NiaH,SeanoG,RobergeS,HuangP,MunnL,JainRK.Invivocompressionandimagingforcausalstudiesofmechanicalforcesinthebrain.Neuro-Oncology2020,22:ii235–ii236.
101. NikmaneshiMR,BFiroozabadiB,MunnLL.Amechanobiologicalmathematicalmodeloflivermetabolism.BiotechnologyandBioengineering2020.117:2861-2874.
102. NiaHT,DattaM,SeanoG,ZhangS,HoWW,RobergeS,HuangP,MunnLL,JainRK.Invivocompressionandimaginginmousebraintomeasuretheeffectsofsolidstress.NatureProtocols2020.15:2321–2340.https://doi.org/10.1038/s41596-020-0328-2.
103. ShigetaK,MatsuiA,KikuchiH,KleinS,MamessierE,ChenIX,AokiS,KitaharaS,InoueK,ShigetaA,HatoT,RamjiawanRR,StaiculescuD,ZopfD,FiebigL,HobbsGS,QuaasA,DimaS,PopescuI,HuangP,MunnLL,CobboldM,GoyalL,ZhuAX,JainRK,DudaDG.RegorafenibcombinedwithPD1blockadeincreasesCD8T-cellinfiltrationbyinducingCXCL10expressioninhepatocellularcarcinoma.JImmunotherCancer2020.8(2):e001435.doi:10.1136/jitc-2020-001435.PMID:33234602;PMCID:PMC7689089.
104. AokiS,InoueK,KleinS,HalvorsenS,ChenJ,MatsuiA,NikmaneshiMR,KitaharaS,HatoT,ChenX,KawakuboK,NiaHT,ChenI,SchanneDH,MamessierE,ShigetaK,KikuchiH,RamjiawanRR,SchmidtTC,IwasakiM,YauT,HongTS,QuaasA,PlumPS,DimaS,PopescuI,BardeesyN,MunnLL,BoradMJ,SassiS,JainRK,ZhuAX,DudaDG.Placentalgrowthfactorpromotestumourdesmoplasiaandtreatmentresistanceinintrahepaticcholangiocarcinoma.Gut2021.gutjnl-2020-322493.
105. VoutouriC,NikmaneshiMR,HardinCC,PatelAB,VermaA,KhandekarMJ,DuttaS,StylianopoulosT,MunnLL,JainRK.InsilicodynamicsofCOVID-19phenotypesforoptimizingclinicalmanagement.ProceedingsoftheNationalAcademyofSciences2021.118:e2021642118.
106. SubudhiS,VermaA,PatelAB,HardinCC,KhandekarMJ,LeeH,McEvoyD,StylianopoulosT,MunnLL,DuttaS,JainRK.ComparingMachineLearningAlgorithmsforPredictingICUAdmissionandMortalityinCOVID-19.NPJDigitalMedicine20214:87.https://doi.org/10.1038/s41746-021-00456-x.
Non-peer reviewed scientific or medical publications/materials in print or other media
Reviews, Chapters and Editorials 1. JainRK,KoenigGC,DellianM,FukumuraD,MunnLL,MelderRJ.Leukocyte-endothelialadhesionand
angiogenesisintumors.CancerandMetastasisReviews1996;15:195-204.2. MelderRJ,KoenigG,MunnLL,JainRK.Adhesionofactivatednaturalkillercellstotumornecrosisfactor-
alpha-treatedendotheliumunderphysiologicalflowconditions.NaturalImmunity1996;15:154-163.3. JainRK,LLMunnLL,FukumuraD,MelderRJ.Invitroandinvivoquantificationofadhesionbetween
leukocytesandvascularendothelium.In:MorganJR,YarmushML,editorsMethodsinMolecularMedicineTotowa,NJ,HumanaPress,Inc1998;18:553-575.
4. JainRK,MunnLL.Leakyvessels?CallAng1!NatureMedicine2000;6:131-2.5. McDonaldD,MunnL,JainR.Vasculogenicmimicry:howconvincing,hownovel,andhowsignificant?
AmericanJournalofPathology2000;156:383-388.6. JainRK,MunnLL,FukumuraD.Transparentwindowmodelsandintravitalmicroscopy:imaginggene
expression,physiologicalfunctionanddrugdeliveryintumors.In:Teicher,B,editorTumorModelsinCancerResearchTotowa,NJ,HumanaPress,Inc2001;pp647-672.
7. JainRK,MunnLL,FukumuraD.Dissectingtumoursusingintravitalmicroscopy.NatureReviewsCancer2002;2:266-276.
8. MunnLL.Aberrantvasculararchitectureintumorsanditsimportanceindrug-basedtherapies.DrugDiscoveryToday2003;8:396-403.
9. JainRK,BrownEB,MunnLL,FukumuraD.Intravitalmicroscopyofnormalanddiseasedtissuesinmice.In:LiveCellImaging-ALaboratoryManual,GoldmanRDandSpectorDL,editors,CSHLPress,ColdSpringHarbor,NY2004;Chapter24,pp435-466.
Curriculum Vitae Lance L. Munn, PhD
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10. BrownEB,MunnLL,FukumuraD,JainRK.Apracticalguidetoinvivoimagingoftumors.In:MPLSMLaboratoryManual,ColdSpringHarborLaboratoryPress,ColdSpringHarbor,NY2005;Chapter92,pp695-700.
11. MunnLL.Analyticalapproachestoleukocyte-endotheliuminteractions.In:MicrovascularResearch:BiologyandPathology,SheproD,editorElsevierPress,Amsterdam2005;Chapter117,pp791-794.
12. BockhornM,JainRK,MunnLL.Activeversuspassivemechanismsinmetastasis:docancercellscrawlintovessels,oraretheypushed?LancetOncol2007;8:444–48.
13. JainRK,MunnLL.Vascularnormalizationasarationaleforcombiningchemotherapywithantiangiogenesisagents.Principles&PracticeofOncology2007;21:1-7.
14. MunnLLandJainA.Designandfabricationofmicrofluidicdevicesforflow-basedseparationofbloodcells.Lab-on-a-ChipTechnology(Vol2):BiomolecularSeparationandAnalysis2009Herold,KEandRasooly,A(Eds)CaisterAcademicPress,Norfolk,UKISBN978-1-904455-47-9.
15. JainRK,MunnLL,FukumuraD.TransparentWindowModelsandIntravitalMicroscopy:ImagingGeneExpression,PhysiologicalFunctionandTherapeuticEffectsinTumors.In:TumorModelsInCancerResearch,BeverlyATeicher,edCancerDrugDiscoveryandDevelopment,2011,Part9,641-679,DOI:101007/978-1-60761-968-0_26.
16. BrownE,MunnLL,FukumuraD,JainRK.Invivoimagingoftumors.ColdSpringHarbProtoc,2010:pdbprot5452.
17. FukumuraD,DudaDG,MunnLL,JainRK.Tumormicrovasculatureandmicroenvironment:novelinsightsthroughintravitalimaginginpre-clinicalmodels.Microcirculation2010;17:206-225.
18. MunnLL,Kamoun,W,Dupin,M,TyrrellJA.Modelingstructuralandfunctionaladaptationoftumorvesselnetworksduringanti-angiogenictherapy.ModelingTumorVasculature,TrachetteJackson,ed.,SpringerScience,2011.
19. GoelS,DudaDG,XuL,MunnLL,BoucherY,FukumuraD,JainRK.Normalizationofthevasculaturefortreatmentofcancerandotherdiseases.PhysiolRev2011;91:1071-1121.
20. KozinSV,DudaDG,MunnLL,JainRK.Isvasculogenesiscrucialfortheregrowthofirradiatedtumours?NatRevCancer2011;11:532.
21. MunnLL,KamounWS.LaserScanningMethodologiesforMeasuringRBCVelocity,Flux,HematocritandShearRateinVascularNetworks.TheTextbookofAngiogenesisandLymphangiogenesis:MethodsandApplications.ZudaireEnrique,Cuttitta,F(Eds.)Springer2012,pp417-431.
22. JainRK,MunnLL,FukumuraD.Rabbitearchambers.ColdSpringHarbProtoc.2012Jul1;2012(7):813-14.doi:10.1101/pdb.prot070045.PubMedPMID:22753607.
23. JainRK,MunnLL,FukumuraD.Cornealpocketassayinrabbits.ColdSpringHarbProtoc.2012Sep1;2012(9):1017-8.doi:10.1101/pdb.prot070052.PubMedPMID:22949714.
24. JainRK,MunnLL,FukumuraD.Mammaryfatpadchamberpreparationinmice.ColdSpringHarbProtoc.2012Oct1;2012(10):1113-4.doi:10.1101/pdb.prot071506.PubMedPMID:23028075.
25. JainRK,MunnLL,FukumuraD.Mammaryfatpadtumorpreparationinmice.ColdSpringHarbProtoc.2012Oct1;2012(10):1115-6.doi:10.1101/pdb.prot071514.PubMedPMID:23028076.
26. JainRK,MunnLL,FukumuraD.Lymphangiographyofthemousetail.ColdSpringHarbProtoc.2012Nov1;2012(11):1177-8.doi:10.1101/pdb.prot072108.PubMedPMID:23118364.
27. JainRK,MunnLL,FukumuraD.Lymphangiographyofthemouseear.ColdSpringHarbProtoc.2012Nov1;2012(11):1179-80.doi:10.1101/pdb.prot072116.PubMedPMID:23118365.
28. JainRK,MunnLL,FukumuraD.Pancreatictumorpreparationinmice.ColdSpringHarbProtoc.2012Dec1;2012(12).doi:pii:pdb.prot072363.10.1101/pdb.prot072363.PubMedPMID:23209145.
29. JainRK,MunnLL,FukumuraD.Livertumorpreparationinmice.ColdSpringHarbProtoc.2012Dec1;2012(12).doi:pii:pdb.prot072371.10.1101/pdb.prot072371.PubMedPMID:23209146.
30. JainRK,MunnLL,FukumuraD.Lungwindowpreparationinmice.ColdSpringHarbProtoc.2013Jan1;2013(1).doi:pii:pdb.prot072678.10.1101/pdb.prot072678.PubMedPMID:23282642.
31. JainRK,MunnLL,FukumuraD.MeasuringInterstitialDiffusion,Convection,andBindingParametersinMouseTumors.ColdSpringHarbProtoc.2013,2013(7).
32. JainRK,MunnLL,FukumuraD.MeasuringInterstitialpHandpO2inMouseTumors.ColdSpringHarbProtoc.2013,2013(7).
Curriculum Vitae Lance L. Munn, PhD
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33. JainRK,MunnLL,FukumuraD.MeasuringLeukocyte-EndothelialInteractionsinMice.ColdSpringHarbProtoc.2013,2013(6).
34. JainRK,MunnLL,FukumuraD.MeasuringVascularPermeabilityinMice.ColdSpringHarbProtoc.2013,2013(5).
35. JainRK,MunnLL,FukumuraD.Measuringangiogenesisandhemodynamicsinmice.ColdSpringHarbProtoc.2013,2013(4).
36. DudaDG,MunnLL,JainRK.CanWeIdentifyPredictiveBiomarkersforAntiangiogenicTherapyofCancerUsingMathematicalModeling?JNCI2013105:762-765.
37. MunnLL,KunertC,TyrrellJA.ModelingTumorBloodVesselDynamics.inMathematicalMethodsandModelsinBiomedicine--LectureNotesonMathematicalModellingintheLifeSciences,UrszulaLedzewicz,HeinzSchättler,AvnerFriedman,EugeneKashdaned.2013,pp117-147.
38. KeslerCT,LiaoS,MunnLL,PaderaTP.Lymphaticvesselsinhealthanddisease.WileyInterdisciplinaryReviews:SystemsBiologyandMedicine,2013.
39. ChauhanVP,BoucherY,FerroneCR,RobergeS,MartinJD,StylianopoulosT,BardeesyN,DePinhoRA,PaderaTP,MunnLL,JainRK.Compressionofpancreatictumorbloodvesselsbyhyaluronaniscausedbysolidstressandnotinterstitialfluidpressure.CancerCell2014,26(1):14-15.
40. MunnLL,PaderaTP.Imagingthelymphaticsystem.MicrovascularResearch2014:55-63.41. SongJW,BazouD,MunnLL.MicrofluidicModelofAngiogenicSprouting.InVascularMorphogenesis,
Springer,NY.(2015)pp243-254.42. King-,ReinhartMunnLJanmeyP,FletcherD,GerechtS,LevineR,MallickP,McCartyO, C.PhysicalSciences
andEngineeringAdvancesinLifeSciencesandOncology:AWTECGlobalAssessment.Springer,Nov19,2015403pages- .
43. MunnLL.Mechanobiologyoflymphaticcontractions.SeminarsinCell&DevelopmentalBiology.2015Elsevier,38:67-74.
44. MunnLL.FluidMechanicsandTransportinTumors.PhysicalSciencesandEngineeringAdvancesinLifeSciencesandOncology.PartoftheseriesSciencePolicyReports,2016;pp73-88.
45. PaderaTP,MeijerEFJ,MunnLL.TheLymphaticSysteminDiseaseProcessesandCancerProgression.Annu.Rev.Biomed.Eng.(2016)18:125–58.
46. MunnLL,JainRK.TheForcesofCancer.TheScientist.2016;30:52-57.47. MunnLL.CancerandInflammation.WIREsSystemsBiologyandMedicine.2017;9:e1370
doi:10.1002/wsbm.1370.48. StylianopoulosT,MunnLL,JainRK.ReengineeringthePhysicalMicroenvironmentofTumorstoImprove
DrugDeliveryandEfficacy:FromMathematicalModelingtoBenchtoBedside.TrendsinCancer.2018;4(4):292-319.
49. StylianopoulosT,MunnLL,JainRK.ReengineeringtheTumorVasculature:ImprovingDrugDeliveryandEfficacy.TrendsinCancer.2018;4(4):258-59.
50. MunnLL,GarkavtsevI.SLPI:anewtargetforstoppingmetastasis.Aging.2018;10(1):13–14.51. Nowak-SliwinskaP,AlitaloK,AllenE,AnisimovA,AplinAC,AuerbachR,AugustinHG,BatesDO,Van
BeijnumJR,BenderRHF,BergersG,BikfalviA,BischoffJ,BöckBC,BrooksPC,BussolinoF,CakirB,CarmelietP,CastranovaD,CimpeanAM,CleaverO,CoukosG,DavisGE,DePalmaM,DimbergA,DingsRPM,DjonovV,DudleyAC,DuftonNP,FendtS-M,FerraraN,FruttigerM,FukumuraD,GhesquièreB,GongY,GriffinRJ,HarrisAL,HughesCCW,HultgrenNW,Iruela-ArispeML,IrvingM,JainRK,KalluriR,KaluckaJ,KerbelRS,KitajewskiJ,KlaassenI,KleinmannHK,KoolwijkP,KuczynskiE,KwakBR,MarienK,Melero-MartinJM,MunnLL,NicosiaRF,NoelA,NurroJ,OlssonA-K,PetrovaTV,PietrasK,PiliR,PollardJW,PostMJ,QuaxPHA,RabinovichGA,RaicaM,RandiAM,RibattiD,RueggC,SchlingemannRO,Schulte-MerkerS,SmithLEH,SongJW,StackerSA,StalinJ,StratmanAN,VanDeVeldeM,VanHinsberghVWM,VermeulenPB,WaltenbergerJ,WeinsteinBM,XinH,Yetkin-ArikB,Yla-HerttualaS,YoderMC,GriffioenAW.Consensusguidelinesfortheuseandinterpretationofangiogenesisassays.Angiogenesis.2018;21(3):425–532.DOI:10.1007/s10456-018-9613-x.
52. NiaHT,MunnLL,JainRK,Mappingphysicaltumormicroenvironmentanddrugdelivery.ClinicalCancerResearch.2019,clincanres.3724.2018.
53. MunnLL,JainRK.Vascularregulationofanti-tumorimmunity.Science365:544-545,2019.DOI:10.1126/science.aaw7875.
Curriculum Vitae Lance L. Munn, PhD
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54. MunnLLandNiaHT.Mechanosensingtensilesolidstresses.ProceedingsoftheNationalAcademyofSciences,116:21960-21962,2019.
55. NiaHT,MunnLL,JainRK.Physicaltraitsofcancer.Science,370,2020.56. MunnLL,StylianopoulosT,JainNK,HardinCC,KhandekarMJ,JainRK.VascularNormalizationtoImprove
TreatmentofCOVID-19:LessonsfromTreatmentofCancer.ClinCancerRes2021.DOI:10.1158/1078-0432.CCR-20-4750.