dermal toxicology · the objectives of the dermal toxicology specialty section (dtss) are to...

Executive Council

PresidentWilliam G. Reifenrath, Ph.D.Stratacor, [email protected]

President ElectJeffrey J. Yourick, Ph.D., [email protected]

Vice PresidentDTSS Newsletter co-EditorCarol L. Sabourin, [email protected]

Secretary-TreasurerAdrienne BlackRutgers [email protected]

Past PresidentGeorge L. DeGeorge, Ph.D., DABTMB Research [email protected]

Senior CouncilorCynthia A. Ryan, B.S.Proctor & [email protected]

CouncilorLinda Mutter, Ph.D.Dow Pharmaceutical Science, [email protected]

Postdoctoral RepresentativeDTSS Newsletter co-EditorLauren Mordasky MarkellPennsylvania State [email protected]

Student RepresentativeGayatri SankaranUniv. California, [email protected]

Dermal Toxicology

Specialty Section

Spring

Newsletter

2011

The President’s Message

The 50th anniversary SOT meeting in Washington DC drewwell over 8,000 attendees, the largest gathering in itshistory. While we did not keep an exact count, I believe ourspecialty section reception also set an attendance record forits relatively brief 11 year history. Two DTSS sponsored

In this Issue:President’s Message………………………………………………………..p.1-2DTSS Mission/ Upcoming Events………………………………….p.2Program Request for SOT 51st Annual Meeting……………..p.3DTSS Award Winners……………………………………………………..p.4Treasurer’s Report/ Student Report………………………………..p.5Symposia Report……………………………………………………………..p.5-6Membership Report………………………………………………………..p.6-7Old Lab Rat Tales by William Reifenrath…………………….…p.8Pictures from the DTSS Reception…………………………………p.9-102010 DTSS Member Publications……………………………………p.11-28

symposia, one on stem cells in wound treatment, chaired by John Graham andJeff Yourick, and one on the role of inflammation in skin cancer, chaired byLauren Markell and Michael Borland, were also well attended.

I am delighted to have had the opportunity to serve as President of ourSpecialty Section this past year and very much appreciative of the supportgiven to me by my fellow officers and members. As with the skin itself, theDTSS office positions undergo a renewal. We had an excellent slate ofcandidates this year and I would like to thank all of you who agreed to run foroffice for volunteering your time and energy. I am happy to report the electionof John Graham as our new Vice President and John Harbell as our newCouncilor. Congratulations and welcome to both of you. Many thanks toCouncilor Cindy Ryan for her service over the past two years; during herservice, participation in the DTSS awards dramatically increased. Linda Mutterwill continue as Senior Councilor and will coordinate awards. Jeff Yourick willshortly take over the reign as your new President and currently is busyorganizing program proposals for the 2012 annual meeting. Carol Sabourin willbecome the new President-Elect and has been instrumental in keeping oursection up to date within SOT. I am sure that both Jeff and Carol will be verysuccessful in their new roles and will ably represent DTSS. We are fortunateto have Adrienne Black continue in her service as Secretary-Treasurer; it’s notan easy job to create the minutes from our sometimes ramblingteleconferences. Likewise, I am happy to report that Lauren Markell willremain in her role as Postdoctoral representative and Gayatri Sankaran asGraduate student representative. (continued page 2)

April 2011 1 Dermal Toxicology Specialty Section

The Mission of DTSSThe objectives of the Dermal Toxicology Specialty Section (DTSS) are to provide a forum forthe interaction of individuals involved in risk assessment, pharmacokinetics, dermalpenetration/ absorption, hypersensitivity and dermal toxicity, regulatory issues, basic skinbiology and other professionals working in the field of dermal research. Members who wishto receive more information on the specialty section should contact William Reifenrath orany of the other Officers by e-mail.

Upcoming Conferences & Events

April 6-9, 2011: US Technical Symposium of the International Society for Biophysics & Imaging of the Skin (Tampa, FL)

April 14-17, 2011: The Symposium on Advanced Wound Care And the Wound Healing Society (Dallas, TX)

April 30, 2011: Deadline for 2012 Annual Meeting Session ProposalsMay 4-11, 2011: 71st Annual Society for Investigative Dermatology Meeting (Phoenix, AZ)June 5-8, 2011: Occupational and Environmental Exposures of Skin to Chemicals (OEESC)

Conference (Toronto, Canada)August 15-October 3, 2011: 51st Society of Toxicology Annual Meeting Abstract SubmissionSeptember 9-12, 2011: 26th Annual Clinical Symposium on Advances in Skin & Wound Care:

The Conference for Prevention and Healing (National Harbor, MD)March 11-15, 2012: 51st Society of Toxicology Annual Meeting (San Francisco, CA)

(continued from page 1) This newsletter comes to you through the efforts of Lauren and Carol. Finally, many thanksto Lauren and Gayatri for preparing the historical poster and brochure for the annual meeting.

Special thanks to George DeGeorge, my predecessor, who served as Past-President and Councilor this pastyear. As the DTSS has grown and matured, his lead in establishing section committees for membership and programproposals will help DTSS accomplish its goals and foster greater participation among the membership.

I would also take this opportunity to acknowledge our award sponsors: Battelle for providing $5,000 for twostudent research awards, Stratacor for providing $1,000 for graduate student and postdoctoral abstract awards, MBResearch Laboratories for providing a Kindle to the student winner at the student reception, and to InformaHealthcare for giving their best paper award. We appreciate their past and continued support. There were manyexcellent proposals and nominations for awards this year; if you did not receive an award, please give it a go nextyear!

I would personally thank the PermeGear and Cetero Research Corporations for donating skin diffusion cellsfor DTSS’s contribution to the 25 year SOT time capsule. On behalf of all the researchers who have contributed tothe development of in vitro topical pharmacokinetics, it is good for SOT to remember all the hard work in this way.

Finally, and most importantly, the DTSS would not exist without the continued support of our members. Yourprogram proposals help shape the scientific content of our annual meetings. Presentation of your original researchat our poster session represents the culmination of not only securing funds to do the research, but also thesuccessful completion of a project. I look forward to seeing all of you again in San Francisco.

William ReifenrathDTSS President


Program Request for the Society of Toxicology 51st Annual MeetingHello DTSS Members,

Thank you for all your program proposal submissions for our recent SOT meeting in DC. Our chapter had two symposium sessions accepted and included in the SOT 2011 program: 1) Mechanisms of Inflammation in Skin Carcinogenesis (Co-chaired by Lauren Mordasky Markell and Michael Borland) and 2) Stem Cell Biology and Cell Therapy Approaches to Understanding Cellular Injury and Wound Healing in Dermal, Ocular, and Pulmonary Injury (Co-chaired by Jeff Yourick and John Graham). Thank you to all the individuals responsible for our successful 2011 DTSS programs. A brief synopsis of the two sessions can be found on pages 5-6 of this newsletter.

Now the task at hand is to prepare and submit proposals for the 2012 SOT meeting in San Francisco. This is one of the most important efforts for DTSS.

The list below describes the 2012 SOT meeting themes. The highest priority for accepting sessions will be given to proposals that align to these themes. However, other relevant toxicology-related topics will be considered by the scientific program committee. • Aberrant Gene Expression in Toxicity and Disease - Epigenetics and MicroRNAs• Characterizing Toxic Modes of Action and Pathways to Toxicity• Influence of Global Climate Change on Environmental Health Issues • Clinical Toxicology from Bedside to the Bench and Back• Regulatory Science: Bridging the Gap between Discovery and Product AvailabilityEven though SOT is accepting proposals for the themes, please note that all proposal submissions will be reviewed by the same criteria and will be given equal consideration. The SOT proposal submission web site is now open. If you are considering a program session and need any help or assistance, please contact Jeff Yourick at [email protected]. Also let me know if you are submitting a proposal so that DTSS is sure to sponsor and endorse it for the review process. Following is a summary of the various session types that are included in the program to help spark your thinking pertaining to proposals.

Session TypesContinuing EducationThese proposals should emphasize quality presentations of generally accepted, state-of-the-art knowledge in toxicology. Courses are scheduled into a one-hour sunrise slot or a four-hour slot, either morning or afternoon. The four-hour courses have a chairperson and 3–4 speakers. Course levels are either basic, for a broad overview, or advanced, for individuals with previous knowledge of the subject.Scientific SessionsSymposia—Proposals for symposia should feature “cutting-edge” science: new areas, concepts, or data in the forefront of toxicology. A symposia session is 165-minutes or less, with two chairpersons and 4–5 speakers.Workshops—Proposals for workshops will be informal, interactive presentations that highlight state-of-the-art knowledge in toxicology with an emphasis on discussion. A workshop session is 165-minutes, with two chairpersons and 4–5 speakers.Innovations in Applied Toxicology and Toxicological Sciences—A limited number of symposia and/or workshops are designated Innovations in Toxicological Sciences (ITS) or Innovations in Applied Toxicology (IAT). ITS will introduce new technologies or scientific disciplines to the membership, and IAT will introduce innovative approaches in applied research.Roundtables—Controversial topics are the basis of roundtable proposals. Each roundtable lasts about 80-minutes. These are moderated discussions, with 2–4 speakers providing a 3–5 minute statement and the balance of the time for questions and Informational Sessions—Sessions are not based on the outcome of scientific research, should present the latest science in toxicology, or other learning opportunities that address the professional interests and needs of toxicologists, and can include the areas of general information or planned scientific activities.DTSS is looking forward to any and all potential program proposals that you may be working on for the 2012 SOT meeting. Please let us know if you need help in developing a program concept.

Thanks,Jeff YourickPresident-ElectProgram Coordinator

Thank you to our sponsors:

2011 DTSS Awards:The 2011 Awards were presented by Cindy Ryan.

DTSS paper of the year: Dae Joon Kim, et al. “Targeted disruption of Stat3 reveals a major role for follicular stem cells in skin tumor initiation” Cancer Research 69: (19) October 1, 2009. (Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Texas).

Battelle Student Awards: Anand Ravindran and Adam Glick (Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University)“A Small Molecule Inhibitor of the TGF-B Type 1 Receptor Sup-presses UVB-Induced Mouse Skin Inflammation” .

Thomas Hill and Robert H. Rice (Dept. of Environmental Toxicology, University of California at Davis)“DOUX Influence on epidermal barrier function: Arsenic response and possible novel biomarker of Exposure?”

Stratacor Postdoc toral Award: Neera Tewari-Singh (Pharmaceutical Sciences, University Of Colorado Denver, Aurora, Colorado) “Therapeutic efficacy of catalytic antioxidant AEOL 10150 in attenuating sulfur mustard analog 2-chloroethyl ethyl sulfide induced skin injury” .

Stratacor Student Award: Lauren Mordasky Markell (Center for Molecular Toxicology and Carcinogenesis. Penn State University) “Pharmacological inhibition of the TGFβ type I receptor induces premalignant keratinocyte terminal differentiation”.

Informa Paper of the Year Award:A new in vitro method for identifying chemical sensitizers combining peptide biding with ARE/EpRE-mediated gene expression in human skin cells. McKim, JM. Jr., Keller DJ. III, Gorski, JR. Cutaneous and Ocular Toxicology, 2010. 29(3) 171-192.

Please check out the following link to find information and deadlines related to submission of abstracts and papers for the upcoming 2012 awards. http://www.toxicology.org/ISOT/SS/dtss/awards.asp

DTSS Members – Would you like to become more active in DTSS?If you have any suggestions or recommendation on how to make our specialty section better or better able to serve your needs, please email your suggestions to:

Bill ReifenrathPresident, [email protected]


http://www.stratacor-inc.com/home.htm

http://www.mbresearch.com/

http://www.cetero.com/

Graduate Student/Postdoctoral Report:Thank you to everyone who stopped by the DTSS Historical Highlights poster during the Student/Postdoctoral Mixer at the Annual Meeting. We enjoyed getting to discuss the benefits of DTSS membership and encourage you to apply at this website: http://www.toxicology.org/ISOT/SS/dtss/membership.html. Again, MB Research Laboratories sponsored an Amazon Kindle giveaway to encourage interest in DTSS membership and attendance at our poster. We would also like to thank all graduate students and postdoctoral fellows that submitted their abstracts and proposals for the DTSS awards. We had great participation this year, with 7 Battelle Student Award proposals, 9 graduate student abstract award submissions and 2 postdoctoral abstract award submissions. Please continue to apply and encourage your peers to submit their best work for 2012 award season!

Treasurer’s Report:

The net assets at the end of the calendar year are $13,478. This amountincludes $8478 carried over from the previous year and $5000 receivedfrom Battelle for the Battelle Research Award. The meeting expensesare estimated at $8000 with $2372.98 for the reception costs, $5000.00for the Battelle and $500.00 for the DTSS awards, and approximately$200.00 for ancillary costs including poster printing, purchase ofplaques, etc. Dues have not yet been posted for 2011.

Communications Committee:The communications committee puts together this newsletter and keeps the DTSS website up to date. Check it out at: http://www.toxicology.org/ISOT/SS/dtss/index.htmlWe are always looking for information to share with members, such as meetings, announcements, job openings, postdoctoral positions, etc. that can be posted on the website or included in the newsletter. We are hoping to include updates on hot topics in dermal toxicology and other updates and information of interest to our members. If you have information or new ideas/suggestions for inclusion in the newsletter contact: Carol Sabourin ([email protected]) or Jeff Yourick ([email protected]).

Please forward this newsletter to your

colleagues that might be interested in becoming a

member of DTSS!

SOT 50th Annual Meeting Symposia Report:The Dermal Toxicology Specialty Section sponsored a symposium session at the SOT meeting on March 8,entitled “Stem Cell Biology and Cell Therapy Approaches to Understanding Cellular Injury and Wound Healing inDermal, Ocular, and Pulmonary Injury.” The session was endorsed by the Ocular Toxicology Specialty Session.Thermal and chemical burns as well as chemical injury to the skin, eye, and lung invoke a vast tissue and cellularresponse followed by the initiation of wound healing mechanisms. Stem cells may be defined as undifferentiatedcells that have the capacity for self-renewal and may differentiate into many different cell types when stimulatedby specific cellular signals. Injury to stem cell tissue populations has immense implications for normal repair andrestoration of tissue function after chemical injury. Research on stem cells, such as epidermal stem cells, dermalstem cells, mesenchymal stem cells and embryonic stem cells all have potential to repair and restore structureand function to the skin and eye after extensive injury. This symposium provided attendees with overviews of (a)recent advances in dermal, ocular, and pulmonary induced injury related to stem cells; and (b) potential stemcell and other cell-based therapies as they relate to tissue repair and wound healing. Researchers from the IsraelInstitute for Biological Research (Ness Ziona, Israel), the U.S. Army Medical Research Institute of ChemicalDefense (Aberdeen Proving Ground, MD), Stony Brook University (Stony Brook, NY), the Walter Reed ArmyInstitute of Research (Silver Spring, MD), and Rutgers University (Piscataway, NJ) provided the lectures.


75%

10%

15%

Mar 2011FullAssocStudent

Total = 169

38%

26%

12%

11%

5%6%

2%

Mar 2011IndustryAcademiaGovernmentConsultingResearch (CRO)Research (NP)Other

SOT Dermal Toxicology Specialty Section MembershipSubmitted by: George DeGeorge

SOT 50th Annual Meeting Symposia Report (continued):

DTSS also sponsored a symposium session at the SOT Meeting on March 9 entitled “Mechanisms ofInflammation in Skin Carcinogenesis.” This session was endorsed by the Carcinogenesis and Molecular BiologySpecialty Sections. The World Health Organization finds that 30% of all human cancers are cancer of the skin,and one in five Americans will develop skin cancer in their lifetime. Furthermore, increased cancer mortality hasbeen linked to a history of non-melanoma skin cancer. The majority of skin cancers arise from chemical contactor exposure to ultraviolet (UV) radiation, but a complete understanding the mechanisms involved in cancerdevelopment remain elusive. This symposium was organized to gather scientists from academia, governmentand contract research agencies who are leaders in skin carcinogenesis to discuss the mechanisms by which theinflammatory microenvironment alters skin tumor formation and progression, the importance of epidermalhomeostasis, the differential roles of key inflammatory cells that contribute to the tumor phenotype, how mousemodels can be applied to human relevance, and how this research impacts risk assessment and regulation.Researchers from the National Cancer Institute (Bethesda and Frederick, MD), Ohio State University(Colombus, OH), Penn State University (University Park, PA) and Charles River Preclinical Services (Horsham,PA) provided the lectures.

By Membership Category By Organization Category


0

20

40

60

80

100

120

140

160

180

200

Jan-07 Jul-07 Jan-08 Jul-08 Jan-09 Jul-09 Jan-10 Jul-10 Jan-11

Total Members

red dot = SOT takes this point as the yearly f igure

189

136146

152

180169

0

50

100

150

200

Nov 2007 Dec 2008 Dec 2009 Dec 2010 Mar 2011

To

tal M

em

bers

Dermal Specialty Section Membership Estimated 2011

Actual

The "dip" occurs when SOT when members who have not yet renewed their dues are excluded from the active member count.

“Estimated" indicates an arbitrary 5% increase over December of last year.

SOT Dermal Toxicology Specialty Section Membership


Old Lab Rat Tales by William Reifenrath

My first job, as a newly commissioned Captain in the Army, was at the Letterman ArmyInstitute of Research on the Presidio of San Francisco. I was asked to work on re-formulatingDEET (N,N-diethyl-m-toluamide), the military topical insect repellent. At that time (1976),the formulation was 75% DEET and 25% alcohol, one of the few instances when the activeingredient was essentially the vehicle. Despite being an effective mosquito repellent, almostno one would admit to using it, perhaps because it was viewed as an Army product andtherefore suspect. It came in a dark green squeeze bottle and soldiers found it handy forstarting campfires, sort of like the barbeque charcoal starter fluid. Some soldiers refused touse it, saying the smell would give their position away. They would smoke cigarettes instead,claiming the smoke warded off the mosquitoes. This prompted a study to show that DEETcould be detected only within about 8 feet of the user, while cigarette smoke could be detecteda mile away.One of the tools we used in the laboratory to test new formulations of DEET was an evaporation apparatus, developed by my predecessors, as they knew that efficacy was related to evaporation rates. Test formulations were placed on metal planchets (H) and DEET vapor

was collected in a toluenescrubber (J). From a purelyengineering standpoint,this apparatus was quiteimpressive, and was madefurther complicated byreplacing the planchet withcadaver skin and adding apump and fractioncollector to collect skinpenetration receptor fluid.Over the years thatfollowed, we madeimprovements to simplifythe equipment and duringthe 1980’s we used theapparatus to test the skindisposition of otherchemicals of militaryinterest. I did not realize itat the time, but this wasthe start of my research indermal toxicology.


The 2011 DTSS Reception


President Bill Reifenrath and

President-Elect Jeff YourickSecretary -Treasurer

Adrienne Black

Past-President George DeGeorge and

President Bill Reifenrath

Councilor Cindy Ryan and DTSS Stratacor

Student Award winner, Lauren Mordasky

Markell President Bill Reifenrath an d DTSS Stratacor

Post doctoral Award winner, Neera Tewari-Singh

Councilor Cindy Ryan and DTSS paper of the year

winner, Dae Joon Kim

Vice-President Carol Sabourin, President Bill Reifenrath,

and DTSS Battelle Student Award winner, Thomas Hill

Vice-President Carol Sabourin, President Bill

Reifenrath, and DTSS Battelle Student Award winner,

Anand Ravindran

Wally Hayes presented the Informa Paper of

the Year Award (group photo unavailable)

The 2011 DTSS Reception


The following is a listing of publications by DTSS members that were published in 2010. Once a year we feature a listing of peer-reviewed publications by specialty section members (with skin as a keyword) that are available on PubMed. While the editors do their very best to find relevant publications based on the current membership list, it is likely that mistakes will occur and we apologize if we have left any publications out.

Abraham NF, Mercer SE, Pandey S, LaBombardi VJ, Phelps RG. A diffuse painful desquamating rash. Neth J Med. 2010 Nov;68(11):370, 374.

Adler S, Bicker G, Bigalke H, Bishop C, Blümel J, Dressler D, Fitzgerald J, Gessler F, Heuschen H, Kegel B, Luch A, Milne C, Pickett A, Ratsch H, Ruhdel I, Sesardic D, Stephens M, Stiens G, Thornton PD, Thürmer R, Vey M, Spielmann H, Grune B, Liebsch M. The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting. Altern Lab Anim. 2010 Aug;38(4):315-30. PMID: 20822324

Aeby P, Ashikaga T, Bessou-Touya S, Schepky A, Gerberick F, Kern P, Marrec-Fairley M, Maxwell G, Ovigne JM, Sakaguchi H, Reisinger K, Tailhardat M, Martinozzi-Teissier S, Winkler P. Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program. Toxicol In Vitro. 2010 Sep;24(6):1465-73.

Anderson SE, Munson AE, Butterworth LF, Germolec D, Morgan DL, Roycroft JA, Dill J, Meade BJ. Whole-body inhalation exposure to 1-bromopropane suppresses the IgM response to sheep red blood cells in female B6C3F1 mice and Fisher 344/N rats. Inhal Toxicol. 2010 Feb;22(2):125-32.

Anumolu SS, Menjoge AR, Deshmukh M, Gerecke D, Stein S, Laskin J, Sinko PJ. Doxycyclinehydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries. Biomaterials. 2011 Feb;32(4):1204-17.

Api AM, Vey M. A new IFRA Standard on the fragrance ingredient, hydroxyisohexyl 3-cyclohexene carboxaldehyde. Contact Dermatitis. 2010 Apr;62(4):254-5. PMID: 20433450

Bamberg CE, Mackay CR, Lee H, Zahra D, Jackson J, Lim YS, Whitfeld PL, Craig S, Corsini E, Lu B, Gerard C, Gerard NP. The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. J Biol Chem. 2010 Mar 5;285(10):7633-44.

Baron ED, Malbasa CL, Santo-Domingo D, Fu P, Miller JD, Hanneman KK, Hsia AH, Oleinick NL, Colussi VC, Cooper KD. Silicon phthalocyanine (pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trial. Lasers Surg Med. 2010 Dec;42(10):728-35.

2010 DTSS Member Publications


Basketter DA, Broekhuizen C, Fieldsend M, Kirkwood S, Mascarenhas R, Maurer K, Pedersen C, Rodriguez C, Schiff HE. Defining occupational and consumer exposure limits for enzyme protein respiratory allergens under REACH. Toxicology. 2010 Feb 9;268(3):165-70. Epub 2009 Dec 21. Review.PMID: 20026217

Basketter DA, Broekhuizen C, Fieldsend M, Kirkwood S, Mascarenhas R, Maurer K, Pedersen C, Rodriguez C, Schiff HE. Defining occupational and consumer exposure limits for enzyme protein respiratory allergens under REACH. Toxicology. 2010 Feb 9;268(3):165-70.

Basketter DA, Kimber I, Hartung T. The evolution of validation: a commentary. Cutan Ocul Toxicol. 2010 Mar;29(1):1-3.

Basketter DA, Kimber I. Skin sensitization, false positives and false negatives: experience with guinea pig assays. J Appl Toxicol. 2010 Jul;30(5):381-6.

Basketter DA, Pons-Guiraud A, van Asten A, Laverdet C, Marty JP, Martin L, Berthod D, Siest S, Giordano-Labadie F, Tennstedt D, Baeck M, Vigan M, Lainé G, Le Coz CJ, Jacobs MC, Bayrou O, Germaux MA. Fragrance allergy: assessing the safety of washed fabrics. Contact Dermatitis. 2010 Jun;62(6):349-54.PMID: 20557341

Basketter DA. Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment. Cutan Ocul Toxicol. 2010 Mar;29(1):4-9. Review.PMID: 19883218

Baynes RE, Barlow B, Mason SE, Riviere JE. Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2542-6. PMID: 20435082

Black AT, Hayden PJ, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD. Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol ApplPharmacol. 2010 Dec 1;249(2):178-87.

Black AT, Joseph LB, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD. Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide. Toxicol ApplPharmacol. 2010 Jun 15;245(3):352-60.

Bockbrader HN, Radulovic LL, Posvar EL, Strand JC, Alvey CW, Busch JA, Randinitis EJ, Corrigan BW, Haig GM, Boyd RA, Wesche DL. Clinical pharmacokinetics of pregabalin in healthy volunteers. J Clin Pharmacol. 2010 Aug;50(8):941-50. PMID: 20147618

Boden G, Silviera M, Smith B, Cheung P, Homko C. Acute tissue injury caused by subcutaneous fat biopsies produces endoplasmic reticulum stress. J Clin Endocrinol Metab. 2010 Jan;95(1):349-52. PMID: 19897673


Bons B, Audebert F, Bitaudeau C, Cachin N, Colson L, Farr C, Fix LA, Gilmour N, Gorni R, Griffiths M, Harris B, Holle V, Kirk S, Meredith E, Pari C, Poinsot P, Renner G; Members of the ColipaCosmetovigilance Task Force. Assessment of undesirable events in cosmetic market surveillance: background, description and use of a causality assessment method in cosmetovigilance. RegulToxicol Pharmacol. 2010 Dec;58(3):349-53.

Borghoff SJ, Parkinson H, Leavens TL. Physiologically based pharmacokinetic rat model for methyl tertiary-butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation. Toxicology. 2010 Sep 10;275(1-3):79-91.

Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager JJ, Hussain SM, Hofmann MC. Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. ToxicolSci. 2010 Aug;116(2):577-89.

Buck J, Hattersley S, Kimber I. Food allergy--science and policy needs--The UK Food Standards Agency Research Programme. Toxicology. 2010 Dec 30;278(3):319-25.

Burgher F, Mathieu L, Lati E, Gasser P, Peno-Mazzarino L, Blomet J, Hall AH, Maibach HI. Experimental 70% hydrofluoric acid burns: histological observations in an established human skin explants ex vivo model. Cutan Ocul Toxicol. 2010 Nov 15. [Epub ahead of print]

Burgher F, Mathieu L, Lati E, Gasser P, Peno-Mazzarino L, Blomet J, Hall AH, Maibach HI. Part 2. Comparison of emergency washing solutions in 70% hydrofluoric acid-burned human skin in an established ex vivo explants model. Cutan Ocul Toxicol. 2010 Nov 18. [Epub ahead of print]

Carey MA, Bradbury JA, Rebolloso YD, Graves JP, Zeldin DC, Germolec DR. Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice. PLoS One. 2010 Jul 15;5(7):e11610.

Cesta MF, Ryman-Rasmussen JP, Wallace DG, Masinde T, Hurlburt G, Taylor AJ, Bonner JC. Bacterial lipopolysaccharide enhances PDGF signaling and pulmonary fibrosis in rats exposed to carbon nanotubes. Am J Respir Cell Mol Biol. 2010 Aug;43(2):142-51. Epub 2009 Sep 8. PMID: 19738159

Chen J, Shiyanov P, Zhang L, Schlager JJ, Green-Church KB. Top-down characterization of a native highly intralinked protein: concurrent cleavages of disulfide and protein backbone bonds. Anal Chem. 2010 Jul 15;82(14):6079-89. PMID: 20560528

Chen YC, Christiani DC, Su HJ, Hsueh YM, Smith TJ, Ryan LM, Chao SC, Lee JY, Guo YL. Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population. Cancer Causes Control. 2010 May;21(5):771-6. Epub 2010 Jan 19. PMID: 20084542

Clothier KA, Leavens T, Griffith RW, Wetzlich SE, Baynes RE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus). J Vet Pharmacol Ther. 2011 Mar 3. PMID: 21366621


Corley RA, Saghir SA, Bartels MJ, Hansen SC, Creim J, McMartin KE, Snellings WM. Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans. Toxicol ApplPharmacol. 2011 Feb 1;250(3):229-44. Epub 2010 Nov 11. PMID: 21074520

Corsini E, Avogadro A, Galbiati V, dell'Agli M, Marinovich M, Galli CL, Germolec DR. In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs). Toxicol ApplPharmacol. 2011 Jan 15;250(2):108-16.

Corsini E, Dell'Agli M, Facchi A, De Fabiani E, Lucchi L, Boraso MS, Marinovich M, Galli CL. Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB(NF-kappaB) signaling. J Agric Food Chem. 2010 Jun 9;58(11):6678-84.

Corsini E, House RV. Evaluating cytokines in immunotoxicity testing. Methods Mol Biol. 2010;598:283-302.

Coulter EM, Jenkinson C, Farrell J, Lavergne SN, Pease C, White A, Aleksic M, Basketter D, Williams DP, King C, Pirmohamed M, Park BK, Naisbitt DJ. Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals. J Invest Dermatol. 2010 Jan;130(1):161-74.

Dewhirst MW, Ong ET, Braun RD, Smith B, Klitzman B, Evans SM, Wilson D. Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br J Cancer. 1999 Apr;79(11-12):1717-22. PMID: 10206282

Dietert RR, DeWitt JC, Germolec DR, Zelikoff JT. Breaking patterns of environmentally influenced disease for health risk reduction: immune perspectives. Environ Health Perspect. 2010 Aug;118(8):1091-9.

Dika E, Fanti PA, Vaccari S, Patrizi A, Maibach HI. Causal relationship between exposure to chemicals and malignant melanoma? A review and study proposal. Rev Environ Health. 2010 Jul-Sep;25(3):255-9.

Doan K, Bronaugh RL, Yourick JJ. In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. Food Chem Toxicol. 2010 Jan;48(1):18-23. PMID: 19747520

Domingo DS, Camouse MM, Hsia AH, Matsui M, Maes D, Ward NL, Cooper KD, Baron ED. Anti-angiogenic effects of epigallocatechin-3-gallate in human skin. Int J Clin Exp Pathol. 2010 Aug 5;3(7):705-9.

Donahue DA, Avalos J, Kaufman LE, Simion FA, Cerven DR. Ocular irritation reversibility assessment for personal care products using a porcine corneal culture assay. Toxicol In Vitro. 2010 Dec 21.


Donahue DA, Kaufman LE, Avalos J, Simion FA, Cerven DR. Survey of ocular irritation predictive capacity using Chorioallantoic Membrane Vascular Assay (CAMVA) and Bovine Corneal Opacity and Permeability (BCOP) test historical data for 319 personal care products over fourteen years. Toxicol In Vitro. 2010 Dec 13. [Epub ahead of print]

Doraiswamy A, Ovsianikov A, Gittard SD, Monteiro-Riviere NA, Crombez R, Montalvo E, Shen W, Chichkov BN, Narayan RJ. Fabrication of microneedles using two photon polymerization for transdermal delivery of nanomaterials. J Nanosci Nanotechnol. 2010 Oct;10(10):6305-12.

Dyk MB, Chen Z, Mosadeghi S, Vega H, Krieger R. Pilot biomonitoring of adults and children following use of chlorpyrifos shampoo and flea collars on dogs. J Environ Sci Health B. 2011 Jan;46(1):97-104.

Eisele KH, Fink K, Vey M, Taylor HV. Studies on the dissociation of botulinum neurotoxin type A complexes. Toxicon. 2011 Mar 15;57(4):555-65. PMID: 21195107

Elangbam CS, Brodie TA, Brown HR, Nold JB, Raczniak TJ, Tyler RD, Lightfoot RM, Wall HG. Vascular effects of GI262570X (PPAR-gamma agonist) in the brown adipose tissue of Han Wistarrats: a review of 1-month, 13-week, 27-week and 2-year oral toxicity studies. Toxicol Pathol. 2002 Jul-Aug;30(4):420-6.

Elkeeb R, Hui X, Chan H, Tian L, Maibach HI. Correlation of transepidermal water loss with skin barrier properties in vitro: comparison of three evaporimeters. Skin Res Technol. 2010 Feb;16(1):9-15.

Ernstgård L, Andersen M, Dekant W, Sjögren B, Johanson G. Experimental exposure to 1,1,1,3,3-pentafluoropropane (HFC-245fa): uptake and disposition in humans. Toxicol Sci. 2010 Feb;113(2):326-36.

Ernstgård L, Lind B, Andersen ME, Johanson G. Liquid-air partition coefficients of 1,1-difluoroethane (HFC152a), 1,1,1-trifluoroethane (HFC143a), 1,1,1,2-tetrafluoroethane (HFC134a), 1,1,1,2,2-pentafluoroethane (HFC125) and 1,1,1,3,3-pentafluoropropane (HFC245fa). J Appl Toxicol. 2010 Jan;30(1):59-62.

Ernstgård L, Norbäck D, Nordquist T, Wieslander G, Wålinder R, Johanson G. Acute effects of exposure to 1 mg/m(3) of vaporized 2-ethyl-1-hexanol in humans. Indoor Air. 2010 Apr;20(2):168-75.

Everley PA, Dillman JF 3rd. A large-scale quantitative proteomic approach to identifying sulfur mustard-induced protein phosphorylation cascades. Chem Res Toxicol. 2010 Jan;23(1):20-5.

Everley PA, Dillman JF 3rd. Genomics and proteomics in chemical warfare agent research: recent studies and future applications. Toxicol Lett. 2010 Oct 20;198(3):297-303.

Farage MA, Maibach HI. Sensitive skin: closing in on a physiological cause. Contact Dermatitis. 2010 Mar;62(3):137-49.


Farahmand S, Maibach HI. Corrigendum to "Estimating skin permeability from physicochemical characteristics of drugs: A comparison between conventional models and an in vivo-based approach" [Int. J. Pharmaceut. 375 (1-2) (2009) 41-47]. Int J Pharm. 2010 Jul 2. [Epub ahead of print]

Ferenczi K, Ohtola J, Aubert P, Kessler. Malignant T cells in cutaneous T-cell lymphoma lesions contain decreased levels of the antiapoptotic protein Ku70. Br J Dermatol. 2010 Sep;163(3):564-71.

Flack SL, Ball LM, Nylander-French LA. Occupational exposure to HDI: progress and challenges in biomarker analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2635-42.

Flack SL, Fent KW, Trelles Gaines LG, Thomasen JM, Whittaker S, Ball LM, Nylander-French LA. Quantitative plasma biomarker analysis in HDI exposure assessment. Ann Occup Hyg. 2010 Jan;54(1):41-54.

Fosse C, Mathieu L, Hall AH, Bocchietto E, Burgher F, Fischbach M, Maibach HI. Decontamination of tetramethylammonium hydroxide (TMAH) splashes: promising results with Diphoterine in vitro. Cutan Ocul Toxicol. 2010 Jun;29(2):110-5.

Frawley R, White KJ Jr, Brown R, Musgrove D, Walker N, Germolec D. Gene Expression Alterations in Immune System Pathways in the Thymus Following Exposure to Immunosuppressive Chemicals. Environ Health Perspect. 2010 Nov 1. [Epub ahead of print]

Freishtat RJ, Iqbal SF, Pillai DK, Klein CJ, Ryan LM, Benton AS, Teach SJ. High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC. J Pediatr. 2010 Jun;156(6):948-52. Epub 2010 Mar 16. PMID: 20236657

Fussell KC, Udasin RG, Gray JP, Mishin V, Smith PJ, Heck DE, Laskin JD. Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase. Free Radic BiolMed. 2011 Jan 4.

Gaines LG, Fent KW, Flack SL, Thomasen JM, Ball LM, Richardson DB, Ding K, Whittaker SG, Nylander-French LA. Urine 1,6-hexamethylene diamine (HDA) levels among workers exposed to 1,6-hexamethylene diisocyanate (HDI). Ann Occup Hyg. 2010 Aug;54(6):678-91.

Gaines LG, Fent KW, Flack SL, Thomasen JM, Ball LM, Zhou H, Whittaker SG, Nylander-French LA. Effect of creatinine and specific gravity normalization on urinary biomarker 1,6-hexamethylene diamine. J Environ Monit. 2010 Mar;12(3):591-9.

Gaines LG, Fent KW, Flack SL, Thomasen JM, Whittaker SG, Nylander-French LA. Factors affecting variability in the urinary biomarker 1,6-hexamethylene diamine in workers exposed to 1,6-hexamethylene diisocyanate. J Environ Monit. 2011 Jan 12;13(1):119-27.

Galbiati V, Mitjans M, Corsini E. Present and future of in vitro immunotoxicology in drug development. J Immunotoxicol. 2010 Oct-Dec;7(4):255-67.


Galbiati V, Mitjans M, Lucchi L, Viviani B, Galli CL, Marinovich M, Corsini E. Further development of the NCTC 2544 IL-18 assay to identify in vitro contact allergens. Toxicol In Vitro. 2010 Dec 21.

Garrett TL, Rapp CM, Grubbs RD, Schlager JJ, Lucot JB. A murine model for sarin exposure using the carboxylesterase inhibitor CBDP. Neurotoxicology. 2010 Sep;31(5):502-8. PMID: 20510297

Gattu S, Maibach HI. Modest but increased penetration through damaged skin: an overview of the in vivo human model. Skin Pharmacol Physiol. 2011;24(1):2-9.

Genovese S, Foreman JE, Borland MG, Epifano F, Gonzalez FJ, Curini M, Peters JM. A natural propenoic acid derivative activates peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Life Sci. 2010 Mar 27;86(13-14):493-8.

Germolec DR, Frawley RP, Evans E. Markers of inflammation. Methods Mol Biol. 2010;598:53-73.

Ghafourian T, Samaras EG, Brooks JD, Riviere JE. Modelling the effect of mixture components on permeation through skin. Int J Pharm. 2010 Oct 15;398(1-2):28-32. PMID: 20643197

Ghafourian T, Samaras EG, Brooks JD, Riviere JE. Validated models for predicting skin penetration from different vehicles. Eur J Pharm Sci. 2010 Dec 23;41(5):612-6. PMID: 20816954

Gill EM, Straseski JA, Rasmussen CA, Liliensiek SJ, Eliceiri KW, Ramanujam N, White JG, Allen-Hoffmann BL. Visualization of morphological and molecular features associated with chronic ischemia in bioengineered human skin. Microsc Microanal. 2010 Apr;16(2):117-31.mPMID: 20199713

Gilpin S, Hui X, Maibach H. In vitro human skin penetration of geraniol and citronellol. Dermatitis. 2010 Feb;21(1):41-8.

Gilpin S, Maibach H. Allergic contact dermatitis caused by farnesol: clinical relevance. Cutan OculToxicol. 2010 Dec;29(4):278-87.

Gimenez-Arnau A, Maurer M, De La Cuadra J, Maibach H. Immediate contact skin reactions, an update of Contact Urticaria, Contact Urticaria Syndrome and Protein Contact Dermatitis -- "A Never Ending Story". Eur J Dermatol. 2010 Sep-Oct;20(5):552-62.

Gittard SD, Ovsianikov A, Akar H, Chichkov B, Monteiro-Riviere NA, Stafslien S, Chisholm B, Shin CC, Shih CM, Lin SJ, Su YY, Narayan RJ. Two Photon Polymerization-Micromolding of Polyethylene Glycol-Gentamicin Sulfate Microneedles. Adv Eng Mater. 2010 Apr;12(4):B77-B82.

Gordon MK, Desantis A, Deshmukh M, Lacey CJ, Hahn RA, Beloni J, Anumolu SS, Schlager JJ, Gallo MA, Gerecke DR, Heindel ND, Svoboda KK, Babin MC, Sinko PJ. Doxycycline hydrogels as a potential therapy for ocular vesicant injury. J Ocul Pharmacol Ther. 2010 Oct;26(5):407-19.PMID: 20925577


Gordon MK, Desantis A, Deshmukh M, Lacey CJ, Hahn RA, Beloni J, Anumolu SS, Schlager JJ, Gallo MA, Gerecke DR, Heindel ND, Svoboda KK, Babin MC, Sinko PJ. Doxycycline hydrogels as a potential therapy for ocular vesicant injury. J Ocul Pharmacol Ther. 2010 Oct;26(5):407-19. PMID: 20925577

Gray JP, Heart E. Usurping the mitochondrial supremacy: extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion. Toxicol MechMethods. 2010 May;20(4):167-74.

Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species. Toxicol Appl Pharmacol. 2010 Sep 1;247(2):76-82.

Guo TL, Germolec DR, Roesh DM, White KL Jr. Immunomodulation in female B₆C₃F₁ mice following treatment with the HIV protease inhibitor saquinavir for 28 days by gavage. J Immunotoxicol. 2010 Oct-Dec;7(4):289-97.

Habib N, Salaro C, Al-Ghaithi K, Phelps RG, Saggar S, Cohen SR. Severe aphthous stomatitisassociated with oral calcineurin and mTOR inhibitors. Int J Dermatol. 2010 Jan;49(1):91-4.

Haslauer CM, Springer JC, Harrysson OL, Loboa EG, Monteiro-Riviere NA, Marcellin-Little DJ. In vitro biocompatibility of titanium alloy discs made using direct metal fabrication. Med Eng Phys. 2010 Jul;32(6):645-52.

Heck DE, Shakarjian M, Kim HD, Laskin JD, Vetrano AM. Mechanisms of oxidant generation by catalase. Ann N Y Acad Sci. 2010 Aug;1203:120-5.Heck DE. It's the plastic!: commentary on the article by Vetrano et al. on page 134. Pediatr Res. 2010 Aug;68(2):99. PMID: 20631588

Hostynek JJ, Dreher F, Maibach HI. Human skin penetration of a copper tripeptide in vitro as a function of skin layer. Inflamm Res. 2011 Jan;60(1):79-86.

Hostynek JJ, Dreher F, Maibach HI. Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy. Inflamm Res. 2010 Nov;59(11):983-8.

Hostynek JJ, Maibach HI. Fentanyl transdermal patches: overview of cutaneous adverse effects in humans. Cutan Ocul Toxicol. 2010 Dec;29(4):241-6.

Jan YH, Heck DE, Gray JP, Zheng H, Casillas RP, Laskin DL, Laskin JD. Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells. Chem Res Toxicol. 2010 Jun 21;23(6):1045-53.


Jensen UB, Yan X, Triel C, Woo SH, Christensen R, Owens DM. A distinct population of clonogenicand multipotent murine follicular keratinocytes residing in the upper isthmus. J Cell Sci. 2008 Mar 1;121(Pt 5):609-17. PMID: 18252795

Jester JV, Ling J, Harbell J. Measuring depth of injury (DOI) in an isolated rabbit eye irritation test (IRE) using biomarkers of cell death and viability. Toxicol In Vitro. 2010 Mar;24(2):597-604.

Jírová D, Basketter D, Liebsch M, Bendová H, Kejlová K, Marriott M, Kandárová H. Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data. Contact Dermatitis. 2010 Feb;62(2):109-16. PMID: 20136894

Kalender A, Selvaraj A, Kim SY, Gulati P, Brûlé S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab. 2010 May 5;11(5):390-401. PMID: 20444419

Kang-Sickel JC, Stober VP, French JE, Nylander-French LA. Exposure to naphthalene induces naphthyl-keratin adducts in human epidermis in vitro and in vivo. Biomarkers. 2010 Sep;15(6):488-97.

Kerk N, Strozyk EA, Pöppelmann B, Schneider SW. The mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cells. J Invest Dermatol. 2010 Sep;130(9):2259-68. PMID: 20505748

Kern PS, Gerberick GF, Ryan CA, Kimber I, Aptula A, Basketter DA. Local lymph node data for the evaluation of skin sensitization alternatives: a second compilation. Dermatitis. 2010 Feb;21(1):8-32. PMID: 20137736

Kim DJ, Tremblay ML, Digiovanni J. Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoSOne. 2010 Apr 22;5(4):e10290.

Kimber I, Basketter DA, Dearman RJ. Chemical allergens--what are the issues? Toxicology. 2010 Feb 9;268(3):139-42.

Kimber I, Basketter DA, Gerberick GF, Ryan CA, Dearman RJ. Chemical Allergy: Translating Biology into Hazard Characterization. Toxicol Sci. 2010 Nov 22. PMID: 21097995

Kimber I, Basketter DA, Gerberick GF, Ryan CA, Dearman RJ. Chemical Allergy: Translating Biology into Hazard Characterization. Toxicol Sci. 2011 Mar;120 Suppl 1:S238-68.

Kimber I, Basketter DA, McFadden JP, Dearman RJ. Characterization of skin sensitizing chemicals: A lesson learnt from nickel allergy. J Immunotoxicol. 2010 Nov 11. PMID: 21067469

Kimber I, Dearman RJ. An assessment of the ability of phthalates to influence immune and allergic responses. Toxicology. 2010 May 27;271(3):73-82.


Kimber I, Dearman RJ. The local lymph node assay and skin sensitization testing. Methods Mol Biol. 2010;598:221-31.

Lalko JF, Kimber I, Dearman RJ, Gerberick GF, Sarlo K, Api AM. Chemical reactivity measurements: Potential for characterization of respiratory chemical allergens. Toxicol In Vitro. 2010 Nov 17. PMID: 21092755

Lam M, Lee Y, Deng M, Hsia AH, Morrissey KA, Yan C, Azzizudin K, Oleinick NL, McCormick TS, Cooper KD, Baron ED. Photodynamic therapy with the silicon phthalocyanine pc 4 induces apoptosis in mycosis fungoides and sezary syndrome. Adv Hematol. 2010;2010:896161.

Laskin DL, Chen L, Hankey PA, Laskin JD. Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. J Leukoc Biol. 2010 Aug;88(2):373-82.

Laskin DL, Sunil VR, Fakhrzadeh L, Groves A, Gow AJ, Laskin JD. Macrophages, reactive nitrogen species, and lung injury. Ann N Y Acad Sci. 2010 Aug;1203:60-5.

Laskin DL, Sunil VR, Gardner CR, Laskin JD. Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol. 2011 Feb 10;51:267-88.

Laskin JD, Black AT, Jan YH, Sinko PJ, Heindel ND, Sunil V, Heck DE, Laskin DL. Oxidants and antioxidants in sulfur mustard-induced injury. Ann N Y Acad Sci. 2010 Aug;1203:92-100.

Leavens TL, Xia XR, Lee HA, Monteiro-Riviere NA, Brooks JD, Riviere JE. Evaluation of perfusedporcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles. ToxicolLett. 2010 Aug 1;197(1):1-6. PMID: 20385219

Liljelind I, Norberg C, Egelrud L, Westberg H, Eriksson K, Nylander-French LA. Dermal and inhalation exposure to methylene bisphenyl isocyanate (MDI) in iron foundry workers. Ann OccupHyg. 2010 Jan;54(1):31-40.

Liu Y, Luo W, Chen S. Comparison of gene expression profiles reveals aberrant expression of FOXO1, Aurora A/B and EZH2 in lesional psoriatic skins. Mol Biol Rep. 2010 Nov 30. [Epub ahead of print].

Loveless SE, Api AM, Crevel RW, Debruyne E, Gamer A, Jowsey IR, Kern P, Kimber I, Lea L, Lloyd P, Mehmood Z, Steiling W, Veenstra G, Woolhiser M, Hennes C. Potency values from the local lymph node assay: application to classification, labelling and risk assessment. Regul Toxicol Pharmacol. 2010 Feb;56(1):54-66. Epub 2009 Sep 4. Review. PMID: 19733604

Maderna E, Corsini E, Franzini A, Giombini S, Pollo B, Broggi G, Solero CL, Ferroli P, Messina G, Marras C. Expression of vascular endothelial growth factor receptor-1/-2 and nitric oxide in unruptured intracranial aneurysms. Neurol Sci. 2010 Oct;31(5):617-23.


Malaviya R, Sunil VR, Cervelli J, Anderson DR, Holmes WW, Conti ML, Gordon RE, Laskin JD, Laskin DL. Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):89-99.

Martires KJ, Domingo DS, Hsia A, Fu P, Cooper KD, Baron ED. Effects of pimecrolimus versus triamcinolone on Langerhans cells after UV exposure. Exp Dermatol. 2010 Dec 17.

McGinty D, Jones L, Letizia CS, Api AM. Fragrance material review on 3-methyl-2-buten-1-ol. Food Chem Toxicol. 2010 Jan;48 Suppl 3:S64-9. Review. PMID: 20141880

McGinty D, Jones L, Letizia CS, Api AM. Fragrance material review on 7-nonen-2-ol, 4,8-dimethyl-. Food Chem Toxicol. 2010 Jan;48 Suppl 3:S103-7. Review. PMID: 20141873

McGinty D, Letizia CS, Api AM. Fragrance material review on (Z)-2-penten-1-ol. Food ChemToxicol. 2010 Jan;48 Suppl 3:S84-6. Review. PMID: 20141884

McGinty D, Letizia CS, Api AM. Fragrance material review on 2-methyl-2-hepten-6-ol. Food ChemToxicol. 2010 Jan;48 Suppl 3:S82-3. Review. PMID: 20141883

McGinty D, Letizia CS, Api AM. Fragrance material review on 2-methyl-3-buten-2-ol. Food ChemToxicol. 2010 Jan;48 Suppl 3:S97-100. Review. PMID: 20141889

McGinty D, Letizia CS, Api AM. Fragrance material review on 3,7-dimethyl-1,6-nonadien-3-ol. Food Chem Toxicol. 2010 Jan;48 Suppl 3:S52-5. Review. PMID: 20141877

McGinty D, Letizia CS, Api AM. Fragrance material review on 4-methyl-3-decen-5-ol. Food ChemToxicol. 2010 Jan;48 Suppl 3:S93-6. Review. PMID: 20141888

McGinty D, Letizia CS, Api AM. Fragrance material review on 6-ethyl-3-methyloct-6-en-1-ol. Food Chem Toxicol. 2010 Jan;48 Suppl 3:S108-10. Review. PMID: 20141874

McGinty D, Letizia CS, Api AM. Fragrance material review on dihydromyrcenol. Food ChemToxicol. 2010 Jan;48 Suppl 3:S70-5. Review. PMID: 20141881

McGinty D, Letizia CS, Api AM. Fragrance material review on isophytol. Food Chem Toxicol. 2010 Jan;48 Suppl 3:S76-81. Review. PMID: 20141882

McGinty D, Letizia CS, Api AM. Fragrance material review on methylheptenol. Food Chem Toxicol. 2010 Jan;48 Suppl 3:S56-8. Review. PMID: 20141878

McGinty D, Letizia CS, Api AM. Fragrance material review on phytol. Food Chem Toxicol. 2010 Jan;48 Suppl 3:S59-63. Review. PMID: 20141879

Meyer V, Schneider SW, Görge T. [Dermatologic aspects of anticoagulation]. Hautarzt. 2010 Aug;61(8):705-16; quiz 717-8. Review. German. PMID: 20644902


Mishin V, Gray JP, Heck DE, Laskin DL, Laskin JD. Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med. 2010 Jun 1;48(11):1485-91.

Mitjans M, Galbiati V, Lucchi L, Viviani B, Marinovich M, Galli CL, Corsini E. Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro. Toxicol In Vitro. 2010 Sep;24(6):1803-9.

Monteiro-Riviere NA, Oldenburg SJ, Inman AO. Interactions of aluminum nanoparticles with human epidermal keratinocytes. J Appl Toxicol. 2010 Apr;30(3):276-85.

Mordasky Markell L, Pérez-Lorenzo R, Masiuk KE, Kennett MJ, Glick AB. Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression. Carcinogenesis. 2010 Dec;31(12):2127-35.

Mörk AK, Johanson G. Chemical-specific adjustment factors for intraspecies variability of acetone toxicokinetics using a probabilistic approach. Toxicol Sci. 2010 Jul;116(1):336-48.

Morton CA, Downie F, Auld S, Smith B, van der Pol M, Baughan P, Wells J, Wootton R. Community photo-triage for skin cancer referrals: an aid to service delivery. Clin Exp Dermatol. 2011 Apr;36(3):248-54. PMID: 21070338

Narayan RJ, Adiga SP, Pellin MJ, Curtiss LA, Hryn AJ, Stafslien S, Chisholm B, Shih CC, Shih CM, Lin SJ, Su YY, Jin C, Zhang J, Monteiro-Riviere NA, Elam JW. Atomic layer deposition-based functionalization of materials for medical and environmental health applications. Philos Transact A Math Phys Eng Sci. 2010 Apr 28;368(1917):2033-64.

Nohynek GJ, Antignac E, Re T, Toutain H. Safety assessment of personal care products/cosmetics and their ingredients. Toxicol Appl Pharmacol. 2010 Mar 1;243(2):239-59. PMID: 20005888

Olivier KJ Jr, Price KD, Hutto DL, Lerche NW, Mansfield KG, Simmons JH, Taylor K, Myers LP, Ouyang Y, Evans EW. Naturally occurring infections in non-human primates (NHP) and immunotoxicity implications: discussion sessions. J Immunotoxicol. 2010 Apr-Jun;7(2):138-46.

Olivry T, Bizikova P, Dunston SM, Bond R, Halliwell R, Loeffler A, Pucheu-Haston CM, Chen M, Peter Marinkovich M. Clinical and immunological heterogeneity of canine subepidermal blistering dermatoses with anti-laminin-332 (laminin-5) auto-antibodies. Vet Dermatol. 2010 May 4. [Epubahead of print]

Patlolla AK, Hussain SM, Schlager JJ, Patlolla S, Tchounwou PB. Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice. Environ Toxicol. 2010 Dec;25(6):608-21. doi: 10.1002/tox.20621. PMID: 20549644


Patrzyk M, Hoene A, Jarchow R, Wilhelm L, Walschus U, Zippel R, Schlosser M. Time course of fibronectin in the peri-implant tissue and neointima formation after functional implantation of polyester-based vascular prostheses with different porosity in pigs. Biomed Mater. 2010 Oct;5(5):055003. PMID: 20826907

Piehl M, Gilotti A, Donovan A, DeGeorge G, Cerven D. Novel cultured porcine corneal irritancy assay with reversibility endpoint. Toxicol In Vitro. 2010 Feb;24(1):231-9.

Piomelli S, Lamola AA, Poh-Fitzpatrick MF, Seaman C, Harber LC. Erythropoietic protoporphyriaand lead intoxication: the molecular basis for difference in cutaneous photosensitivity. I. Different rates of disappearance of protoporphyrin from the erythrocytes, both in vivo and in vitro. PMID: 1202082

Pree I, Shamji MH, Kimber I, Valenta R, Durham SR, Niederberger V. Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules. Clin Exp Allergy. 2010 Sep;40(9):1346-52.

Pucheu-Haston CM, Copeland LB, Haykal-Coates N, Ward MD. Maternal respiratory sensitization and gestational allergen exposure does not affect subsequent pup responses to homologous or heterologous allergen. J Immunotoxicol. 2010 Mar;7(1):57-67.

Pucheu-Haston CM, Copeland LB, Vallanat B, Boykin E, Ward MD. Biomarkers of acute respiratory allergen exposure: screening for sensitization potential. Toxicol Appl Pharmacol. 2010 Apr 15;244(2):144-55.

Qiu W, Li X, Tang H, Huang AS, Panteleyev AA, Owens DM, Su GH. Conditional Activin Receptor Type IB (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality. J Invest Dermatol. 2010 Dec 30.

Radcliffe PM, Leavens TL, Wagner DJ, Olabisi AO, Struve MF, Wong BA, Tewksbury E, Chapman GD, Dorman DC. Pharmacokinetics of radiolabeled tungsten ((188)W) in male Sprague-Dawleyrats following acute sodium tungstate inhalation. Inhal Toxicol. 2010 Jan;22(1):69-76.

Rao UN, Lee SJ, Luo W, Mihm MC Jr, Kirkwood JM. Presence of tumor-infiltrating lymphocytes and a dominant nodule within primary melanoma are prognostic factors for relapse-free survival of patients with thick (t4) primary melanoma: pathologic analysis of the e1690 and e1694 intergroup trials. Am J Clin Pathol. 2010 Apr;133(4):646-53.

Rasmussen C, Gratz K, Liebel F, Southall M, Garay M, Bhattacharyya S, Simon N, Vander ZandenM, Van Winkle K, Pirnstill J, Pirnstill S, Comer A, Allen-Hoffmann BL. The StrataTest® human skin model, a consistent in vitro alternative for toxicological testing. Toxicol In Vitro. 2010 Oct;24(7):2021-9. Epub 2010 Aug 3.PMID: 20688150

Rasmussen CA, Gibson AL, Schlosser SJ, Schurr MJ, Allen-Hoffmann BL. Chimeric composite skin substitutes for delivery of autologous keratinocytes to promote tissue regeneration. Ann Surg. 2010 Feb;251(2):368-76. PMID: 20010085


Rehal B, Maibach H. Percutaneous absorption of vapors in human skin. Cutan Ocul Toxicol. 2010 Nov 20.

Rho O, Kim DJ, Kiguchi K, Digiovanni J. Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Mol Carcinog. 2010 Jul 20.

Riviere JE, Brooks JD, Yeatts JL, Koivisto EL. Surfactant effects on skin absorption of model organic chemicals: implications for dermal risk assessment studies. J Toxicol Environ Health A. 2010;73(11):725-37. PMID: 20391115

Riviere JE, Brooks JD. Predicting skin permeability from complex chemical mixtures: dependency of quantitative structure permeation relationships on biology of skin model used. Toxicol Sci. 2011 Jan;119(1):224-32. PMID: 20947718

Riviere JE. New technologies for application to veterinary therapeutics. Handb Exp Pharmacol. 2010;(199):191-210. Review. PMID: 20204588

Ruff AL, Dillman JF 3rd. Sulfur mustard induced cytokine production and cell death: investigating the potential roles of the p38, p53, and NF-kappaB signaling pathways with RNA interference. J Biochem Mol Toxicol. 2010 May;24(3):155-64.

Ryan LM, Brandoli C, Freishtat RJ, Wright JL, Tosi L, Chamberlain JM. Prevalence of vitamin D insufficiency in African American children with forearm fractures: a preliminary study. J PediatrOrthop. 2010 Mar;30(2):106-9. PMID: 20179554

Saghir SA, Bartels MJ, Snellings WM. Dermal penetration of ethylene glycol through human skin in vitro. Int J Toxicol. 2010 May-Jun;29(3):268-76. PMID: 20448259

Saghir SA, Zhang F, Rick DL, Kan L, Bus JS, Bartels MJ. In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis. Regul Toxicol Pharmacol. 2010 Jul-Aug;57(2-3):129-35. Epub 2010 Jan 22. PMID: 20096743

Samberg ME, Oldenburg SJ, Monteiro-Riviere NA. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environ Health Perspect. 2010 Mar;118(3):407-13.

Samberg ME, Orndorff PE, Monteiro-Riviere NA. Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods. Nanotoxicology. 2010 Nov 1.

Sartorelli P, Ahlers HW, Cherrie JW, Kezic S, Johanson G, Filon FL, Nielsen JB, Shepherd A, Stull J, Williams F. The 2008 ICOH Workshop on Skin Notation. Med Lav. 2010 Jan-Feb;101(1):3-8.

Schneider SW, Metze D, Bonsmann G. Treatment of so-called idiopathic follicular mucinosis with hydroxychloroquine. Br J Dermatol. 2010 Aug;163(2):420-3. PMID: 20302581


Schrand AM, Rahman MF, Hussain SM, Schlager JJ, Smith DA, Syed AF. Metal-based nanoparticlesand their toxicity assessment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Sep-Oct;2(5):544-68. Review. PMID: 20681021

Schrand AM, Schlager JJ, Dai L, Hussain SM. Preparation of cells for assessing ultrastructurallocalization of nanoparticles with transmission electron microscopy. Nat Protoc. 2010;5(4):744-57. PMID: 20360769

Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, GoethemFV, Vassallo M, Vinardell P, Zuang V. A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches. Toxicol In Vitro. 2010 Feb;24(1):1-9.

Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, GoethemFV, Vassallo M, Vinardell P, Zuang V. A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches. Toxicol In Vitro. 2010 Feb;24(1):1-9. PMID: 19490935Shakarjian MP, Heck DE, Gray JP, Sinko PJ, Gordon MK, Casillas RP, Heindel ND, Gerecke DR, Laskin DL, Laskin JD. Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci. 2010 Mar;114(1):5-19.

Sharma HS, Hussain S, Schlager J, Ali SF, Sharma A. Influence of nanoparticles on blood-brain barrier permeability and brain edema formation in rats. Acta Neurochir Suppl. 2010;106:359-64. PMID: 19812977

Sharma HS, Sharma A, Hussain S, Schlager J, Sjöquist PO, Muresanu D. A new antioxidant compound H-290/51 attenuates nanoparticle induced neurotoxicity and enhances neurorepair in hyperthermia. Acta Neurochir Suppl. 2010;106:351-7. PMID: 19812976

Shaw FL, Cumberbatch M, Kleyn CE, Begum R, Dearman RJ, Kimber I, Griffiths CE. Langerhanscell mobilization distinguishes between early-onset and late-onset psoriasis. J Invest Dermatol. 2010 Jul;130(7):1940-2.

Sivamani RK, Ghiya M, Maibach HI. Shedding light on sunscreens and their labels: Testing policies need to match actual use. Am J Prev Med. 2010 Jun;38(6):679-81.

Smith B, Curtis A, Parsons A, Yosipovitch G, Sangüeza OP. A 41-year-old woman with a scaly erythematous plaque admixed with erosions on the groin, back, and legs: challenge. Nutritional deficiency. Am J Dermatopathol. 2010 Dec;32(8):828, 850. PMID: 20559111


Smith MJ, Germolec DR, Luebke RW, Sheth CM, Auttachoat W, Guo TL, White KL Jr. Immunotoxicity of dibromoacetic acid administered via drinking water to female B₆C₃F₁ mice. J Immunotoxicol. 2010 Oct-Dec;7(4):333-43.

Ständer S, Schneider SW, Weishaupt C, Luger TA, Misery L. Putative neuronal mechanisms of sensitive skin. Exp Dermatol. 2009 May;18(5):417-23. Review. Erratum in: Exp Dermatol. 2009 Dec;18(12):1096. PMID: 19382311

Sunil VR, Patel KJ, Shen J, Reimer D, Gow AJ, Laskin JD, Laskin DL. Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. Toxicol Appl Pharmacol. 2011 Jan 1;250(1):10-8.

Sunil VR, Patel-Vayas K, Shen J, Gow AJ, Laskin JD, Laskin DL. Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol. 2011 Feb 1;250(3):245-55.

Taylor RS, Fotopoulos G, Maibach H. Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions. Curr Med Res Opin. 2011 Jan 13.

Teng YJ, Li YP, Wang JW, Yang KH, Zhang YC, Wang YJ, Tian JH, Ma B, Wang JM, Yan X. Bioengineered skin in diabetic foot ulcers. Diabetes Obes Metab. 2010 Apr;12(4):307-15. Review. PMID: 20380651

Thyssen JP, Skare L, Lundgren L, Menné T, Johansen JD, Maibach HI, Lidén C. Sensitivity and specificity of the nickel spot (dimethylglyoxime) test. Contact Dermatitis. 2010 May;62(5):279-88.

Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker Jr W, Hussain SM, Ali SF. Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability. Nanotoxicology. 2010 Dec 22. PMID: 21175299

Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker W Jr, Hussain SM, Ali SF. Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci. 2010 Nov;118(1):160-70. PMID: 20713472

Vetrano AM, Laskin DL, Archer F, Syed K, Gray JP, Laskin JD, Nwebube N, Weinberger B. Inflammatory effects of phthalates in neonatal neutrophils. Pediatr Res. 2010 Aug;68(2):134-9.

Vidal C, Kapelusznik L, Goldberg M, Halverstam C, Daefler S, Calfee D, Phelps RG. The dermatologic manifestation of novel influenza A(H1N1). Arch Dermatol. 2010 Jan;146(1):101-2.

Wa CV, Maibach HI. Mapping the human face: biophysical properties. Skin Res Technol. 2010 Feb;16(1):38-54.


Walschus U, Hoene A, Kochanowski A, Neukirch B, Patrzyk M, Wilhelm L, Schröder K, Schlosser M.Quantitative immunohistochemical examination of the local cellular reactions following implantation of biomaterials. J Microsc. 2011 Apr;242(1):94-9. PMID: 21118237

Wang CY, Maibach HI. Why minimally invasive skin sampling techniques? A bright scientific future. Cutan Ocul Toxicol. 2010 Oct 1. [Epub ahead of print]

Wang J, Schwartz HT, Barr MM. Functional specialization of sensory cilia by an RFX transcription factor isoform. Genetics. 2010 Dec;186(4):1295-307.

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity. Mol Cancer Ther. 2010 Jun;9(6):1852-63.

Weaver JL, McKinnon K, Germolec DR. Phenotypic analysis using very small volumes of blood. Curr Protoc Cytom. 2010 Oct;Chapter 6:Unit 6.30.

Weinberger B, Laskin JD, Sunil VR, Sinko PJ, Heck DE, Laskin DL. Sulfur mustard-induced pulmonary injury: Therapeutic approaches to mitigating toxicity. Pulm Pharmacol Ther. 2010 Sep 17.

Weir L, Robertson D, Leigh IM, Vass JK, Panteleyev AA. Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes. Biochim Biophys Acta. 2011 Jan;1813(1):60-72.

Xia XR, Monteiro-Riviere NA, Riviere JE. An index for characterization of nanomaterials in biological systems. Nat Nanotechnol. 2010 Sep;5(9):671-5. PMID: 20711178

Xia XR, Monteiro-Riviere NA, Riviere JE. Intrinsic biological property of colloidal fullerene nanoparticles (nC60): lack of lethality after high dose exposure to human epidermal and bacterial cells. Toxicol Lett. 2010 Aug 16;197(2):128-34. PMID: 20493935

Xia XR, Monteiro-Riviere NA, Riviere JE. Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol. 2010 Jan 1;242(1):29-37. PMID: 19796651

Xie L, Hayashida S, Yan X, Tsuji G, Nakahara T, Takeuchi S, Takahara M, Shan B, Uchi H, Moroi Y, Furue M. Overexpression of stromal cathepsin K expression correlates with invasiveness of extramammary Paget's disease. Eur J Dermatol. 2010 May-Jun;20(3):415-6. PMID: 20388610

Yadegari M, Whyte MP, Mumm S, Phelps RG, Shanske A, Totty WG, Cohen SR. Buschke-Ollendorffsyndrome: absence of LEMD3 mutation in an affected family. Arch Dermatol. 2010 Jan;146(1):63-8.

Yan X, Chen B, Lin Y, Li Y, Xiao Z, Hou X, Tan Q, Dai J. Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model. Diabetes Res Clin Pract. 2010 Oct;90(1):66-72. PMID: 20667614


Yan X, Takahara M, Xie L, Oda Y, Nakahara T, Uchi H, Takeuchi S, Tu Y, Moroi Y, Furue M. Stromalexpression of cathepsin K in squamous cell carcinoma. J Eur Acad Dermatol Venereol. 2011 Mar;25(3):362-5. PMID: 20524946

Yan X, Takahara M, Xie L, Tu Y, Furue M. Cathepsin K expression: a useful marker for the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. Histopathology. 2010 Sep;57(3):486-8. PMID: 20727023

Yang BB, Lum P, Chen A, Arends R, Roskos L, Smith B, Pérez Ruixo JJ. Pharmacokinetic and pharmacodynamic perspectives on the clinical drug development of panitumumab. ClinPharmacokinet. 2010 Nov 1;49(11):729-40. PMID: 20923247

Yanofsky VR, Mercer SE, Phelps RG. Histopathological variants of cutaneous squamous cell carcinoma: a review. J Skin Cancer. 2011;2011:210813. Epub 2010 Dec 29.

Young G, Smith GW, Leavens TL, Wetzlich SE, Baynes RE, Mason SE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats. Res Vet Sci. 2010 Jul 15. PMID: 20638089

Young S, Fabio K, Guillon C, Mohanta P, Halton TA, Heck DE, Flowers RA 2nd, Laskin JD, HeindelND. Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction. Bioorg Med Chem Lett. 2010 May 1;20(9):2987-90.

Zanchetta LM, Kirk D, Lyng F, Walsh J, Murphy JE. Cell-density-dependent changes in mitochondrial membrane potential and reactive oxygen species production in human skin cells post sunlight exposure. Photodermatol Photoimmunol Photomed. 2010 Dec;26(6):311-7.

Zhang LW, Monteiro-Riviere NA. Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes. Toxicol In Vitro. 2010 Mar;24(2):546-51.

Zheng Y, Lai W, Wan M, Maibach HI. Expression of cathepsins in human skin photoaging. Skin Pharmacol Physiol. 2011;24(1):10-21.

Zheng Y, Vieille-Petit A, Chodoutaud S, Maibach HI. Dislodgeable stratum corneum exfoliation: role in percutaneous penetration? Cutan Ocul Toxicol. 2011 Jan 12.

Zhu YH, Song SP, Luo W, Elias PM, Man MQ. Characterization of skin friction coefficient, and relationship to stratum corneum hydration in a normal chinese population. Skin PharmacolPhysiol. 2011;24(2):81-6.


dermal toxicology · the objectives of the dermal toxicology specialty section (dtss) are to...

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