development of the electroanatomical mapping system · mapping system lior gepstein. md, phd the...
TRANSCRIPT
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Development of the Electroanatomical
Mapping System
Lior Gepstein. MD, PhD
The Sohnis Family Laboratory for Cardiac Electrophysiology and Regenerative Medicine
Cardiology Department, Rambam Medical Center
The Bruce Rappaport Faculty of Medicine,
Technion - Israel Institute of Technology
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Stages in the Development and Clinical Use of the Carto System
Conception of the idea, technology development, preclinical studies
Initial human studies
Development of mapping and ablation strategies for complex arrhythmias
Ablation for atrial fibrillation
Related technological developments (imaging, ablation technologies)
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Shlomo Ben-Haim
Founds Biosense in Haifa, Israel in 1993
First clinical cases – November 1995
Johnson & Johnson buys Biosense, Inc. in 1997
Johnson & Johnson merges Biosense, Inc. and Cordis Webster in 1998
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Innovation Requirements
Clinical problem/need
Market
Innovative idea/technology
Innovative environment
Funding/ business plan
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Innovations in Israel
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Innovations in Israel
Teva Industry
Copaxon, Azilect
Stents
InStent, Nir, Many more
Biosense
Revolutionized EP
Given Imaging
Revolutionized GI diagnosis
Ventor
Novel Transapical Valve
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Cardiac Mapping
Mapping is a general term that relates to the assignment and display of encoded-information according to its spatial coordinates.
Cardiac Mapping:
Spatial coordinates of the recording sites
Electrophysiological information
Beat-by-beat single site vs. multi-site recording
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Locatable tip:• Real-time• Six degrees of freedom
The Navistar Catheter
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•An External Ultra-Low Magnetic Field Emitter
The Location Pad
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Catheter Tip Location
Gepstein et al. Circulation 1997
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Carto Locatable Catheter
Magnetic Sensor, Real time
6 degrees of freedom; location and
orientation
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Gepstein L, et al. Circulation 1997
Ben-Haim SA, et al. Nature Medicine 1996
Statistic in vitro
accuracy: 0.2 mm
Statistic in vivo
accuracy: 0.7 mm
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Surface Reconstruction
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System records location through constant interrogation of the
magnetic field generated from the location pad
Records Location 1
Surface Reconstruction
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Records location 2
Surface Reconstruction
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Records location 3
Surface Reconstruction
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• Superimposes point location and local activation
times
10ms
50
ms
100ms
Surface Reconstruction
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-11 ms
25 msThe initial phase :
matching an ellipsoid to the acquired points.
Bounding all the points with an egg shell shape.
The second phase: Stretching and bending the shell to fit the points.
Smooth Reconstruction
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--35 ms
68 ms
When each point is added,
the shape of the
reconstruction is updated.
The shape of the chamber is
stretched and bent to
intersect through the real
points locations.
Smooth Reconstruction
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Surface Reconstruction
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Surface Reconstruction
Gepstein, L. et al. Circulation 1998
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To compensate for patient X, Y, Z movements and respiration
Location Reference
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Point Acquisition Each point has
location and electrical information associated with it
While adding points, each point is connected to neighboring points
Electrical activation is interpolated between points
A 3D color-coded map is created
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Gepstein et al. Circulation 1997
Pig LV
Pig LV
Pig RA
Pig RV
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Shpun, et al. Circulation 1998
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Stages in the Development and Clinical Use of the Carto System
Background, conception of the idea, technological development, preclinical studies
Initial human studies
Development of mapping and ablation strategies for different arrhythmias
Ablation for atrial fibrillation
Additional technological developments
The future
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Mapping in Humans
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Stages in the Development and Clinical Use of the Carto System
Background, conception of the idea, technological development, preclinical studies
Initial human studies
Development of mapping and ablation strategies for different arrhythmias
Ablation for atrial fibrillation
Additional technological developments
The future
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Three-Dimensional Mapping Systems
Understanding the mechanism of the arrhythmia and the underlying substrate
Defining the anatomy
Designing an ablation strategy
Delivering the therapy (ablation)
Assessment of the lesion
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Mapping Methods: Electrophysiological information
Activation mapping
Propagation maps - videos
Voltage mapping
Pace mapping
Entrainment
Fibrillation indices: FFT, Fragmentation index
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Activation Mapping
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Activation Mapping
Macro reentrant arrhythmias
Mapping of the full cycle-length of the arrhythmias
Head-meets-tail
Focal Arrhythmias
Total activation time < CL
Early (red) surrounded by later sites
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Focal Arrhythmias
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VT in Infant
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VT in Infant
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Macro Reentrant Arrhythmias
Ben-Haim SA, et al. Nature Medicine 1996
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Mapping Methods: Electrophysiological information
Activation mapping
Propagation maps - videos
Voltage mapping
Pace mapping
Entrainment
Fibrillation indices: FFT, Fragmentation index
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Gepstein et al. Circulation 1998
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Scar-related Atrial Tachycardias
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Scar – Inferior Myocardial Infarction
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ARVD- Voltage Mapping
Boulos, Gepstein. J Am Coll Cardiol 2001
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Hemochromatosis
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Three-Dimensional Mapping Systems
Understanding the mechanism of the arrhythmia and the underlying substrate
Defining the anatomy
Designing an ablation strategy
Delivering the therapy (ablation)
Assessment of the lesion
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Gepstein et al. Circulation 1999
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Isthmus ablation for atrial flutter
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Stages in the Development and Clinical Use of the Carto System
Background, conception of the idea, technological development, preclinical studies
Initial human studies
Development of mapping and ablation strategies for different arrhythmias
Ablation for atrial fibrillation
Additional technological developments
The future
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Stages in the Development and Clinical Use of the Carto System
Background, conception of the idea, technological development, preclinical studies
Initial human studies
Development of mapping and ablation strategies for different arrhythmias
Ablation for atrial fibrillation
Additional technological developments
The future
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Integrated Digital Lab
Robotic Control Rotational Angiography 3D Image Integration
Real Time ImagingAdvanced
Signal Processing
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• Three-dimensional volume/surface reconstruction of cardiac chambers and big vessels from 2D raw data CT/MR scan
Objectives
CT/MR Imaging
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FAM vs. EA map done in Gated mode
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GUI: Force Value and Direction continued…
Within Threshold Above ThresholdBelow Threshold
Note the vector that is colored
according to the force values
defined by the thresholds
Below the threshold
Within the threshold
Above the threshold
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The Future
Better understanding of patient-specific arrhythmia mechanism (atrial fibrillation)
Non-destructive treatments
Gene therapy
Cell therapy
“Conducting cables”
“Molecular ablation”
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Gepstein et al.,
Circulation (1998)
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Thanks:
Shlomo Ben-HaimBiosense engineersGal Hayam, Shlomo ShpunRona Shofti, Edith Cohen
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