diagnosis, delivery and direction implants using new technologies alan murray professor of neural...
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Diagnosis, Delivery and Diagnosis, Delivery and Direction Direction
Implants Using New Implants Using New TechnologiesTechnologies
Alan MurrayAlan Murray
Professor of Neural ElectronicsProfessor of Neural Electronics
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
AgendaAgenda
DiagnosisDiagnosis• Sensors on chip and the engineering Sensors on chip and the engineering
issues they raiseissues they raise Delivery (drug) Delivery (drug)
• Drug storage and release structures and Drug storage and release structures and the engineering issues they raisethe engineering issues they raise
DirectionDirection• Cell guidanceCell guidance
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Devices and diagnosis:Devices and diagnosis:Shapes and Sizes?Shapes and Sizes?
70-100 µm
Human hair 1µm = 10-6 (1/1000000th) of 1 metreOr 1 million µm = 1metreRoughly 10,000 hairsbreadths/metre
Human neuron
4-100 µm
0.1-1µm
Transistor
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Diagnosis - SensorsDiagnosis - Sensors
From earlier work From earlier work on an ingestible on an ingestible chipchip• TemperatureTemperature
easyeasy
• ConductivityConductivity fairly easyfairly easy
• pHpH trickytricky
• OO22 concentration concentration trickiertrickier
Most interesting for tumour biology!
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Implantable Microsystems for Implantable Microsystems for Personalised Anti-Cancer Therapy Personalised Anti-Cancer Therapy
(IMPACT)(IMPACT)
Typical microchip
Chip tumour microenvironmentMeasure hypoxia (O2concentration)
and other markers of tumour activityRadiotherapy planningChemotherapy planning?Chemotherapy delivery?
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
IMPACT (EPSRC Proposal, £5.3M)IMPACT (EPSRC Proposal, £5.3M)
Professor Alan Murray -School of EngineeringProfessor Mark Bradley - School of Chemistry
Professor Steve McLaughlin – Engineering, Heriot-WattProfessor Ian Kunkler - Edinburgh Cancer Research Centre
Professor David Argyle - Veterinary Clinical StudiesProfessor Joyce Tait - Innogen Centre - Science,
Technology and Innovation Studies
Implantable Microsystems for PersonalisedAnti-Cancer Therapy (IMPACT)
Interview, EPSRC Towers, 22nd Feb ()
5 years in the making
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Look – no wires …Look – no wires …
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Devices and diagnosis:Devices and diagnosis:Drug deliveryDrug delivery
So far … chips can be:So far … chips can be:• tiny tiny • wirelesswireless
Chips can containChips can contain• SensorsSensors
OO22, pH, conductivity, temperature, pH, conductivity, temperature biomarkersbiomarkers
Chips can also store and release Chips can also store and release liquidliquid
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Direction:Direction:Cell guidanceCell guidance
Neurones, glia … also stem cells, kidney cells …
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Potential benefitsPotential benefits
Personalised therapyPersonalised therapy Treatment at homeTreatment at home Optimised timing/location of therapyOptimised timing/location of therapy
• Chemotherapy released local to tumourChemotherapy released local to tumour Maximise tumour damageMaximise tumour damage Minimise collateral/systemic damageMinimise collateral/systemic damage
Rebuild broken nervous system Rebuild broken nervous system componentscomponents
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Future trendsFuture trends
More, better, smaller sensorsMore, better, smaller sensors More and better algorithms for More and better algorithms for
making sense of sensorsmaking sense of sensors Better securityBetter security Flexible substratesFlexible substrates
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
Some IssuesSome Issues InsertionInsertion
• Stereotactic is possible … long thin chipsStereotactic is possible … long thin chips Bio-foulingBio-fouling
• Body’s reaction to foreign objectsBody’s reaction to foreign objects Wireless communicationsWireless communications
• Radio/ultrasoundRadio/ultrasound Signals from sensors/to drug-deliverySignals from sensors/to drug-delivery
• ““noisy” and not 100% accuratenoisy” and not 100% accurate SecuritySecurity Need to deliver therapy at the tumour’s Need to deliver therapy at the tumour’s
(in)convenience, not on a regular schedule(in)convenience, not on a regular schedule
Alan Murray – University of EdinburghAlan Murray – University of Edinburgh
But these are only the scientist’s But these are only the scientist’s concerns …concerns …
We NEED a wider viewWe NEED a wider view• Hence the inclusion of social scientists Hence the inclusion of social scientists
and potential patients in the IMPACT and potential patients in the IMPACT proposalproposal
• Hence my being here todayHence my being here today