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PRESENTATION

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PRESENTATION

2

HISTORY

1949 : Creation of the Company by Mr Pierre GUERIN at MAUZE-SUR-LE- MIGNON, born of a small family concern for agriculture and dairies maitenance equipment.Employees: 5 peopleHead office : 179 Grand ’Rue - 79210 MAUZE-SUR-LE-MIGNON

1959 : « PIERRE GUERIN S.A. » is bornEmployees : 75 peopleTurnover : 2.600.000 F

1962 : Acquisition at NIORT of a 30.000 m² ground and construction of a factory of 1200 m²Employees : 97 peopleTurnover : 8.000.000 F

3

HISTORY

1978 : PIERRE GUERIN S.A. became a subsidiary of FIVES-CAIL BABCOCK Company. FIVES-CAIL BABCOCK owns 75 % of assets.

1993 : Acquisition of MORITZ Company, specialized in the mixing and blending technologies.The main shareholder of PIERRE GUERIN Co. became the « Compagnie de FIVES-LILLE ».Employees : 360 peopleTurnover : 184.000.000 FF

1996 : Acquisition of 33 % of shares of the Spanish company STORK SISTEMAS ALIMENTARIOS specialised in the construction of stainless steel tanks for the food industries.

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HISTORY1998 : PIERRE GUERIN became 100 % owner of STORK SISTEMAS

ALIMENTARIOS an created a subsidiary PIERRE GUERIN IBERICA S.A. Acquisition of the Company BIOLAFITTE, specialised in biotechnologies.

1999 : In Mai 99, PIERRE GUERIN S.A. created a subsidiary PIERRE GUERIN INOTEC S.A. by the acquisition of the Company INOTEC specialised in automatical transfer for cheese making units (pressed an cooked cheese).

In June 99, PIERRE GUERIN S.A. created the Company PIERRE GUERIN SCHUBERTH S.A. by the acquisition of the Company SCHUBERTH specialised in the manufacturing of stainless steel an special steel tanks an exchangers for the Biotechnology industry an Fine Chemistry

2000 : Creation of a subsidiary « BIOLAFITTE & MORITZ » in United Kingdom.

2002 : PIERRE GUERIN bought up by IK and PIETRI Group became PIERRE GUERIN SAS.

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PIERRE GUERIN SAS

Serving health andtaste

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PIERRE GUERIN ACTIVITIESDesign and manufacture stainless steel equipmentfor the following industries :

Taste Department

+ Milk and sub products :* Storage* Curdling* Cheese* Milky desserts

+ Wine & Beverages :* Red & white wines, Champagnes* Fruit juices* Soft drinks* Mineral or natural waters

+ Food industries :* Biscuits* Chocolate* Fruits * Sauces

Health Department

+ Pharmaceutical :* Pasty and liquid form, powders* Aseptic processes* Research laboratories* Industrial production

+ Biotechnologies :* Cultures* Antibiotics* Vaccines* Blood subproducts

+ Cosmetology :* Beauty creams* Beauty milks* Shampoos and gels* Lotions

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MILK INDUSTRY

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CHEESE INDUSTRY

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FOOD INDUSTRY

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WINE INDUSTRY

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DRINK INDUSTRY

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SERVICES

PackagingTransportOff loadingInstallationQuality controlTrainingMaintenanceAfter Sales Service

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PRODUCTS

PIERRE GUERIN developed technologies to suit your applications.Here are :

Processing vesselsCIP SystemBIOLAFITTE fermentersMORITZ cream mixersMORITZ & PIERRE GUERIN agitatorsALM homogenisersPOLYMEL powders/liquids blendersPIERRE GUERIN centrifugal & positive rotary lobe pumps 3A

approved , (the only French manufacturer) MORITZ turbospheresA set of components such as valves, vents, cleaning

systems….necessary to the process of your applicationsSoftware and hardware.

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BIO FERMENTATION INDUSTRY

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COSMETIC INDUSTRY

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PRESENTATION PG SAS

Niort workshop area : 38.000 m²1200 tons of stainless steel used every year1800 tanks manufactured every year Testing laboratory facilities

MAUZE head office area : 3.750 m²Mauzé :. Software / Hardware

Division . R&D

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QUALITY CONTROL

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CALCULATION

TÜVCODAP

BRITISH STANDARD SVTI ASITSTOOMWESENFINITE ELEMENT

19

CALCULATION

1

XY

Z

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OUR REFERENCES…

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ADVERTISING

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ADVERTISING

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ADVERTISING

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FACILITIES

Head office :

PIERRE GUERIN S.A.S179, Grand-Rue - B.P. 12

France - 79210 MAUZE-SUR-LE-MIGNONPh. : 33 (0)5 49 26 30 58Fax : 33 (0)5 49 26 34 84Web : www.pierreguerin.frou www.pierreguerin.com

e-mail : [email protected]

Factory :

PIERRE GUERIN S.A.Rue Denis Papin

France - 79000 NIORT

Ph. : 33 (0)5 49 04 78 00Fax : 33 (0)5 49 73 31 89

e-mail : [email protected]

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FACILITIES

Subsidiaries :

PIERRE GUERIN IBERICA S.A.Poligono Industrial Villalonquéjar, 4

Apartado 20309001 BURGOSEspagne

Ph. : 34 9 47 25 91 00Fax : 34 9 47 25 91 50

e-mail : [email protected]

PIERRE GUERIN Ltd.Midland House, Ounsdale Road

WombourneWolverhampton WV5 8BY

EnglandPh. : 44 (0) 1902 891 320Fax : 44 (0) 1902 891 316

e-mail : [email protected]

PIERRE GUERIN SCHUBERTH S.A. Z.I. Les Platières

France - 69440 MORNANTPh. : 33 (0)4 78 48 38 20Fax : 33 (0)4 78 48 38 29

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TANKAGE

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PIERRE GUERIN Sanitary Process Tank

Ra=0.8Grain=180

1.4301 (AISI304)1.4404 (AISI316L)…

TIGMAG(CIRAUTO)

The design itself:Tank, Mixing

CIP/processAccessories:Air Vent

The choice of material

The surface treatment

The polishing procedures

The welding process

CIP/processAccessories:CIP Spraying devices

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MIXING

1992A new kind of mixing propeller developped through a close cooperation with the CNRS - ENSIGC chemical engineering

laboratory in Toulouse

HTPG4Thus, simple vessels have become process vessels, equipped

with efficients tools for agitation mixing and heat transfer.

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MIXING

TARGETSMixing control, main element of your process

Materialize our experience in liquid or pasty productprocessing,

Benefit from our work force’s know how : engineering services, stainless steel flue-shops and machine shops,

Optimize your mixing by means of a profile providing an efficient flow pumping, a minimum shearing respectingfragile products and the whole with a low power output.

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MIXING

MEANSMeasurement of the flow speeds by means of a Laser Doppler anemometer,Measurement of the mixing times by colouration-discolourationof a transparent tank,Measurement of the power consumption through a torque meter,Pilot equipment : 2 transparent tanks of 50 and 200 L.

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MIXING

RESULTS

Birth of the HTPG4 shape, innovation acknowledged by patent.

It matches your requirements.

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MIXING

What the HTPG4 propeller was expected to improve

Before Now

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MIXING

RESULTS

The HTPG 4 propeller is the fruit of the optimisation of different parameters.It ensures :

a maximum discharge efficiency thanks toits oriented flow pattern avoiding centrifugallosses,a low power consumption,a minimum shearing respecting fragileproducts.

It is made in stainless steel and is cleanable inplace (removable blades in option). Its exclusive shape is patented.

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MIXING

PERFORMANCES

The HTPG 4 design induces a sizeable axial flow and avoidsradial leaks. Two upward and downward flows are thusgenerated. The seperation between bothflows is generally lesspronounced with traditionalpropellers. Such hydrodynamics is the keyto the good performances of theHTPG 4 propeller.

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MIXING

INDUSTRIESFood ProduceDrinks and fruit juicesChocolateDairy

SugarWines and alcohols

Bio-pharmacyBiotechnologyFine chemistry

CosmeticsPharmacy

APPLICATIONS

Storage and processStorage and holding in temperatureStorage of milk and culture, curdlingcutting, cristallization, ripening, standardization, fermentationStorage and processAssembling, tartaric precipitation, liquormelting tanks, culture tanks

Fermentation (couple propeller/turbine)Storage of raw material, homogeneousholdingCirculation in the tankProduction of injectable solutions

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PICTURES OF VALUABLE REALIZATIONS…

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SINCE 1993, YEAR OF INTEGRATION OF THE MORITZ PRODUCTS, PIERRE GUERIN IS EVEN MORE INVOLVED IN MIXING TECHNOLOGIES

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TANK ACCESSORIES

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Air Vent is the safety device of a tank

It protects from internal pressure and vacuum damage

Cleaning solution

1. During filling/emptying of the tank

2. Cleaning with hot and cold solutions

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Air Vent is the safety device of a tank

The design of such device requires sophisticated calculation

WHAT ARE THE PARAMETERS ?• Air Vent (open area & pressure drop) • Temperatures of cleaning solution• Flow rate of cleaning solutions• Spray cleaning device• Tank sizes

PIERRE GUERIN has developed a unique softwareto dimension Air Vents

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Air Vent is the safety device of a tank

-16

-14

-12

-10

-8

-6

-4

-2

0

0 2 4 6 8 10Time (sec)

Vacu

um (m

bar)

Vent φ15085°C

Vent φ15060°C

Vent φ30085°C

EXAMPLE

Tank 20 000 L

• If the cleaning solution is at 60°C max.

Vacuum in the tank: < 4mbar

Vent φ150 mm is OK

If instead the temperature of

• Cleaning solution 85°C

Vacuum in the tank: > 14mbar

Damage the tank with Vent φ150

Change the Vent => φ300

Vacuum in the tank: < 1mbar OK

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Atmospheric Vent

Grille anti-insectesAir

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Patented automatic breather For ultra-clean Tank

Without any pilote

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Automatic breathera PIERRE GUERIN safety device

For ultra-clean Tank

Vacuum and over-pressure control without any external pilote.

Screen (0.8mm mesh)

No retention area

CIP

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Automatic breather a PIERRE GUERIN safety device

Overpressure VacuumFor ultra-clean tank

Si le vide >3mbarSi P>100mbar

Without any external pilote

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Automatic breather is the safety device of a tank

For ultra-clean Tank

« SERVICES»

48

Services targets in PG to :

Assist our customers :

►Implementation of PG products & technologies

► Preventive maintenance (spares, maintenance visit, maintenance book)

► Repairing

► Following and evolution of installations

…………………..

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…… but also :

To enable our clients to enjoy our expertising in:► Stainless steel tank manufacturing► Automation of process and tracability of

products► Cleaning and Sterilization in Place (CIP/SIP)► Agitation / Mixing►Thermal treatment► Validation and qualification of installations and

processesBy the supplying of Products and Services

completely adapted to their needs

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ACTIVITIES

SERVICES ON TANKS

PROCESS COMPONENTS AND SPARE PARTS

CUSTOMERS SERVICES

AUTOMATION TRACABILITY

TECHNOLOGICAL DEVELOPMENT

PROCESS EXPERTISINGMAINTENANCE

INSTALLATIONS

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SERVICES ON TANKS

INSTALLATION :

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SERVICES ON TANKS

REPAIRING :

. Weld

. Cracking detection

. Accessories revision

. Heating/Cooling jacket control

. Restitution of surface finish

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SERVICES ON TANKS

SECURISATION - UP DATING :

. Support structure control

. Old sub-frame replacement

. Control and welds dye penetration

. Metallurgic control

. Contamination zones research

. Setting up of ladder, guardrail

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SERVICES ON TANKS

OPTIMIZATION OF PERFOMANCES :

. Setting up of specific agitation

. Heating/cooling jacket adaptation

. Cleaning system improvement

. Insulation adaptation

. Capacity increase

. Setting up of samples, gauges

. Setting up of pneumatic vents

. Sealing of agitator' shaft

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PROCESS COMPONENTS

Pumps

Liquid/Powder Blending systems

Homogenisers

Tank accessories

Valves

Tubular cartridge

Fittings

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AGITATION

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MACHINES

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SPARE PARTS AND ACCESSORIES

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AUTOMATION - TRACABILITY

Automation of manual installation

Programmable Logic Controller Replacement

Modification or renovation of automation. Producing tools optimization. Events and production set

tracability. Maintenance following. Preventive maintenance

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AUTOMATION - TRACABILITY

Supervising functions

Batch functions

Tracability functions :

WHY ? Beginning of January 1st, 2005, the Food activity operators will be obliged to supply without any delay the total tracability of their production.

Securisation

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INSTALLATIONS MAINTENANCE

Preventive maintenance :

- Spare parts list- Maintenance agreement- Maintenance book

Diagnostic, repairing

Modifications

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TECHNOLOGIGAL DEVELOPMENTPROCESS EXPERTISING

Expertising :Agitation / MixingThermal treatmentCleaning In Place, Sterilization In Place

Services :Audit on placePerformances optimizationNew product processingTrainingValidation Qualification

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… TO SERVE HEALTH

EQUIPMENTEQUIPMENT

AND INSTALLATIONS AND INSTALLATIONS

FOR THE FOR THE

PHARMACEUTICAL PHARMACEUTICAL

AND AND

BIOTECHNOLOGY BIOTECHNOLOGY

INDUSTRIESINDUSTRIES

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… TO SERVE HEALTH

BIOTECHNOLOGY

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EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYBIOTECHNOLOGY

PREPARATION AND STORAGE OF CULTURE MEDIUMSAND FERMENTATION ADDITIVES

FERMENTATION AND CULTURE OF ANIMAL CELLS FOR THE PRODUCTION OF ACTIVE PRINCIPLES (VITAMINS, ANTIBIOTICS, VACCINES, GROWTH HORMONES, MCA)

CONCENTRATION, INACTIVATION AND PURIFICATION OF ACTIVE PRINCIPLES

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EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYBIOTECHNOLOGY

PRODUCT RANGE

BIOCELL™ BIOREACTORS NEP/SEP :LABORATORY, PILOT & INDUSTRY SERIESCLASSIC™ LINE CIP/SIP FERMENTORS :LABORATORY, PILOT & INDUSTRY SERIESTRYTON™ & ADAGIO™ AUTOCLAVABLE BIOREACTORSPREPARATION AND STORAGE VESSELS FOR MEDIA & ADDITIVESMOBILE VESSELS FOR PRODUCT TRANSFERHARVEST AND INACTIVATION VESSELSBIOCLEAN™ CIP UNIT

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BIOCELL™ Bioréactors CIP/SIP Pilote series

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BIOCELL™ Bioreactors CIP/SIP Laboratory series

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CLASSIC™ Bioreactors CIP/SIP

Laboratory Series

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CLASSIC™ Fermentors CIP/SIP

Pilot series

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CLASSIC™ Fermentors CIP/SIP Pilote series

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TRYTON™Autoclavable Bioreactors

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PREPARATION AND STORAGE VESSELS FOR MEDIA & ADDITIVES

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EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYBIOTECHNOLOGY

REFERENCESREFERENCES

AMGEN (U.S.A)AVENTIS PASTEUR (FRANCE)AVENTIS PHARMA (FRANCE)BAXTER (BELGIQUE)BRISTOL- MYERS SQUIBB (U.S.A)DIOSYNTH (GROUPE AKZO NOBEL ) (PAYS BAS)GENENTECH (U.S.A)GLAXOSMITHKLINE (FRANCE - U.K – U.S.A)INTERVET (UK – PAYS BAS)L. F. B (FRANCE)MERIAL (FRANCE - U.S.A)OM PHARMA (SUISSE)PHARMACIA UPJOHN (SUEDE - U.S.A)RHODIA TEXEL (FRANCE)SANOFI (FRANCE)SCHERING PLOUGH (U.S.A)

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… TO SERVE HEALTH

PHARMACY

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EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYPHARMACY

STORAGE OF RAW MATERIALS AND END PRODUCTS

STORAGE AND DISTRIBUTION OF PPI WATER (water for injection)

PREPARATION OF LIQUID FORMS (potable solutes and suspensions, aerosols, etc…)

MANUFACTURING OF PASTY FORMS (creams and ointments, gels, suppository mass)

FORMULATION, FILTRATION AND ASEPTIC STORAGE OF STERILE FORMS (ophthalmic products, injectable solutes and suspensions, nasal solutes)

MIXTURE / DRYING / GRANULATION FOR THE PREPARATION OF DRY FORMS (antibiotics)

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EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYPHARMACY

PRODUCT RANGE

MCD™ LINES CREAM MIXERS :LABORATORY, PILOT & INDUSTRY SERIES

LABOSPHERE™ & TURBOSPHERE™ « ALL-IN-ONE » MIXING, DRYING, GRANULATION MACHINES

STORAGE VESSELS FOR WFI & RAW MATERIALS

MOBILE VESSELS FOR PRODUCT TRANSFERT

MELTING VESSELS

FORMULATION VESSELS FOR LIQUID & STERILE FORMS

BIOCLEAN™ CIP UNIT

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PHARMACEUTICAL FERMENTATION PLANT

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PLATEFORME DE FERMENTATIONcGMP PHARMACEUTIQUE

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EXEMPLE OF PHARMACEUTICAL PLANT

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EXEMPLE OF PHARMACEUTICAL PLANT

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cGMP PHARMACEUTICAL FERMENTATION PLANT

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MIXING, DRYING, GRANULATION MACHINES

84

EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYPHARMACY

REFERENCESREFERENCES

ALCON (BELGIUM)BAXTER (FRANCE)BOEHRINGER (FRANCE)GLAXO WELLCOME (EGYPT – U.S.A.)HOECHST ROUSSEL UCLAF (FRANCE)HOFFMAN LA ROCHE (SWITZERLAND – U.S.A.)MERCK (FRANCE)PFIZER (BELGIUM)PHARMACIA UPJOHN (FRANCE)RHONE POULENC RORER (FRANCE – SPAIN – U.S.A.)SYNTHELABO-SANOFI (FRANCE - BELGIUM)SCHERING PLOUGH (FRANCE)SERVIER (FRANCE – IRELAND)VIRBAC (FRANCE)

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… TO SERVE HEALTH

COSMETICS

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EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYCOSMETICS

PRODUCT RANGE

STORAGE VESSELS FOR ROW MATERIAL

MELTING VESSELS

GEL PREPARATION VESSELS

MCD™ LINE :LABORATORY, PILOT & INDUSTRY SERIES

LOTION PREPARATION VESSELS

SHAMPOO PREPARATION VESSELS

STORAGE VESSELS FOR FINISHED PRODUCTS

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EXPERTISE IN ASEPSIS FROM LABORATORY TO INDUSTRYCOSMETICS

REFERENCESREFERENCES

L‘OREAL

PIERRE FABRE

PROCTER & GAMBLE

RECKITT & COLMAN

SHISEIDO

YVES ROCHER

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Supporting Food and Health Industries