dino set1h3 #3 (gmed=100 rho12=0.340) m.b. nickel (ii...
TRANSCRIPT
-
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●●●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●●●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●●
●
●●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●●
●●
●●
●
●
●
●
● ●
●
●●
●
●
●
●
●●
●●
●
●
● ●
●
●
●
●
● ●
● ●●●
● ●
●●
●
●
●
●
●
●
●
●
● ●●
●
●
●●
●
●●
●●●
●
●
●●
●●
●
●
●
●
●
●
●●●
●●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●●
●●
●
●
●
●
●●
●
●
●
●
●● ●
●
●
●
●
●
● ●●
●
●
●
●●
●
●
●
●
●●
●
● ●
●
●●●
●●
●
●
●
●●
●●
●
●
●
●
●●
●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●● ●
●
●●
●
●●
●●
●●
●
●
●●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
● ●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●●
●●
●
●●
●
●
●
●
●
●
●
●
● ●
●
●
●
●●
●●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●●●
●●
●
●
●
●
●
●
●
●
●
●●●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●
●
●●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●● ●
●
●
●
●●●
●
● ●
●
●
●
●
●
●
●
●
●
●●
●
●
● ●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●●
●●
●
●
●
●●
●
●
●
● ● ●●
●
●
●●
●
● ●●
●
●●
●
●
●
●
●
● ●●
●
● ●●
●
●●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●●
●●
●
●
●
●
●
●●
●
●● ●●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
● ●
●
●
●
●
●
●●
● ●●
●●
●
●
●
●
●●
●
●
●
● ●
●
●
●
●●●●
●
●●
●
●●
●
●
●
●
●● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
● ●
●●
●●
● ● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
● ●●●
●
●●
●
●
●●
●●●
●●●
● ●
●
●
●●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●●
●
●
●●
●
●
●●
●
●
●●
●
●●●
●●
●●
●
●●
●
●
●
●
●
●
●●●
● ●
●
●
●
●●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
● ● ●
●● ●
●●
●
●●
●● ●
●
●
●
●●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●● ●
●
●
●
● ●
●
●
●
●●
●
●
●
●
●
●
● ●
●
● ●●●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●●
●●●●●
●●
●
●●●
● ●
●
●
●●● ●
● ●
●●●● ●
●
●
● ●●●
●
●●
●
●
●
●
●●●
●●
●●●
●
●
●
●
●
●
●
●
●
●●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●●
●
●
●●
●●
●● ●● ●●●●●●●
●
●●●
●
●
●●●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●●
●●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
● ●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●●
●
●●
●
●●
●
●
●
●
●
●
●
●●
●
●●
●●
●
●
●
●
●
●
●
●
●●●●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●●
●●
●
●●
●
●
●
●
●
●
●
●●
●
●
● ●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
● ●
●
●
●
●●
●
●
●
●
●
−4 −3 −2 −1 0 1
−3
−2
−1
01
Dino set1H3 #3 (gMed=100 rho12=0.340)m.b. Nickel (II) chloride 1 mM
First Half
Sec
ond
Hal
f
-
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●●
●
● ●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
● ●
●
●
●
●●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●●
●●
●
●●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
● ●
●● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●●
●●
●
●
●
●
●
●●●
● ●●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●
●
●
●●
●●
●●
●
●
●●
● ●
●
●
●
● ●
●
●●
●●
●
●
●
●
●
●
●●
●●
●●
●
●
●
●
●●
●
●●●
●
●
●
●
●
●● ●
●
●●
●●
●●●
●
●
●
●
●
●●
●
●●
●
●
● ●●
●
●
●
●
●●
●●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●
●●
●
● ●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●●
●●
●
●●●
●●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●●
●
●
●●
●●
●
●● ●
●
●
●
●
●
●
●
●
●●
●
● ●
●●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●●●●
●
●
●
●●
●
●
●
●
● ●
●●
●
●
●
●
●●
● ●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●●
●
●
●
●
●
●
●
●
● ●●
●
●
●●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●●●
●
●● ●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●●
●●
● ●
●
●
●●
●
●
●
●
●
●●
●
●
●
●●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
● ●●
●
●
●●●
● ●
● ●●
●
●
●
●
●
● ●
●●●●●
●
●●
●
●
●●
●●
●
●●
●
●
●
●●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
● ●●●
●
●
●●
●●
●
●
●
●
●●●
●●
●
●
●
●
●
● ●●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
● ●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●●
●
●
●●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●●
●
●
●
●
●●●
●
●●
●
●
●
●
●
● ●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
● ●
●
●
●
●●
●
●●
●
●●
●
●
●●
● ●
●
●
●●●
●●
●
●●●●
●
● ●●●
●●
●
●●
●●●
●
●●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●●
●
●
●
●
●
●●
●
●●
● ●
●●
●●
●
●
●
●
●
● ●
●●
●
●●
●●
●●
●
●
●
●●
●●
●
●
●
●●
●
●●
●
●●
●
●
●
●●●
●
●
●●
●
●
●
●
●
● ●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
● ●●●
●●
●● ●
●
●
●
●
●●
●
●
●
●
●●
●
●
● ●
● ●
●●●●
●
●●●●●●
●
●●●
●
●
●
●●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●●●●●
●
●
●●
●●
●●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●● ● ●
●
●
●
●
●
●
●●
●●
●
●
●
●
● ●●●
●
●●
●●●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
−3 −2 −1 0 1 2
−3
−2
−1
01
2Dino set1H4 #4 (gMed=90 rho12=0.400)
m.b. Cobalt chloride 0.1 mM
First Half
Sec
ond
Hal
f
-
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●
● ●
●●
●
●●
●
●
●
●
●
●
●●
●●
●
●
●● ●
●
● ●
●●●
●●
●
● ●
●
●●
●
●●●
● ●
●
●
●
● ●
●●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●● ●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
● ●
●
●●
●
●
●
●
●●
● ●●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
● ●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●●
●●
●
●
●●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●
●
●
●●
●
●
●
● ●●
●
●
●
●
●
●● ●
●
●●
●
● ●
● ●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●●
● ●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●●
●
●
●
●
●●●
●●
● ●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
● ●
●
●●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●●
●●
●
●
●●
●
●
●
●●
●
●
●
●●
●●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●●●
●
●
●
●
●
● ●
●
●●
●
● ●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●●
●● ●
●●
●
●
●
●
●
●●
●
●●●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
● ●●
●
●
●●
●
●
●
● ●
●●
●
●
●
●
●
●
●●
● ●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●●
●●
●
●
● ●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●●
●
●
●●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
● ●
●
●
●
●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●●
●
●
●
●●
●
●●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●●
●●●
●● ●
●●
●
●
●
●●● ●
●
●●
●
●
●
●
●●
●●
●●
●
●
●●
●
●
● ●
●
●●
●
●
●
●
● ●
●●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●●
●●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●●●
●
●
●●
●
●
●
●●●
●
●
●
●
●●
●
●
●●
● ●
●● ●●
●● ●●●
●
●
●
●
●
●
●●
●
●●●
●
●
●
●
●
●
●
●
●
● ●
●
●
●●
●
●
●
●
●
● ●
●
●●
●
●●●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●●
●
●
●●
●
●
●
●
●●
●
●
●●
●●
●
●
●●
●
●
●
●
●●
●
●
● ●
●●
●
●
●
●
● ●
●
● ●
●●
●
●
●
●
● ●
●
● ● ●
● ●
●
●
● ●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●
● ●● ●
● ●●
●
●
●
●
●
●
●
●●
●
●
● ●
●
●
●●
●●
●
● ●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
−3 −2 −1 0 1
−3
−2
−1
01
Dino set1H5 #5 (gMed=85 rho12=0.281)m.b. Cobalt chloride 0.5 mM
First Half
Sec
ond
Hal
f
-
●
●
●●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●●●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●●●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●● ●
●
●●
●
●●
●●
●●
●
●
●
●●
●
●●
●
●●
●●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●●
●●
●●
●
●
●●
●
●●
●
●●
●
●●
●
●
●
● ●●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●●●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●●
●●
●●●
● ●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●
●
●●
●
●●
● ●●
●
● ●● ●
●
●
●
●
●●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
● ●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●●
●
●
●
●
●●
●●
● ●
●
●
●
●
●
●
● ●
●●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
● ●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
● ●●
●
● ●●
●
●
● ●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
● ●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
● ●●
●●
●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●
●●
●●●
●
●
●
●
●●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●●
●
●●
●
●
●
● ●
●
●
●●
●
●●●
●
●
●●
●
●
●
●
●
●●●
●
●
●●
●
●●
●●
●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
● ●●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●●
● ●
●
●
●
●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●●●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●●
●
●●
●
● ●●●
●
●
●●●
●
●
●
● ●●
●
● ●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
● ● ● ●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
● ●
●
●
●
● ●●
● ●
●
●●
● ●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
● ●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
● ●
●
●
●
●
● ●●
●
●
●
●
●
●●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
● ●
●●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●●
●
●
●
●●
●
●●
●
●
●
●
●
●
●● ●
●
●●
●
●
●
●● ●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●
●●
●●
●
●
●●● ●●
●●●
● ●
●
●●
●● ●●
●●
●
●●
●
●
●●
●●
●
●●
●●
●
●
●● ●
●
●
●
●●
●
●
●
●
● ●●
●
●●
●●
●●
●
●●
●
●●
●●
●
●●
●●
●
● ●●●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
● ●
●●
●●
●
●
●
● ● ●●●
●● ●●
●●
●
●●●
●
●●●
●
●
●
●
●●
●
●
● ●●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
● ●
●●
●●
●
●
●
●
●
●●
●
●
●
●● ●
●
●
●●
●
● ●
●
●●
●
●
●
●● ●
●
●
● ●
●
●●
●●
●
●
● ●●●
●●
●
●
●●
●
●
●
●
●
●
●●
●
●●●
●
●
●
●
●●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
● ●●
●●
●
● ●●
●
●●
●
●
●
●
●
●
● ●
●● ●
● ●●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●●
−3 −2 −1 0 1
−3
−2
−1
01
2Dino set1H6 #6 (gMed=89 rho12=0.343)
m.b. copper (II) chloride 0.32 mM
First Half
Sec
ond
Hal
f
-
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●●
●
●
●●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●●
●
●
●
●
●
●
●
●●
●●●
●●
●●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●● ●
●
●
●●
●
●
●
●
●
●
●
●●●
●
●
●
●●
●●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●●
●
●●
●●
●●
●●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●●
●●
●
●
●●
●
●● ●
●
●
●●
●●
●
●
●
●
●●
● ●
●
●
●●
●
●
●●
●
●●
●
● ●
●●●
●
●
●
●
●●
●
●
●
● ●
●
●
●
●●
●●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●●
●●●
●
●●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
● ●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
● ●
●●●
●
● ●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●●
● ●
●●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●●
● ●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●●
●
●
●
●
●
●
●
●
●
● ●●
●
●●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●●
●●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●●
● ●●
● ●
●
●●
●
●●●
●
●
●●
●
● ●
●
●●
●●
●
●
●●
●
●
●
●
●
●
● ●
●
●
●●
●●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●
●●
●● ●●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●●
●●
●
●
● ●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
● ●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●●
●
●
●●●
●● ●
●
●
●●●
●
●
●
● ●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●●●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●●●
●
●
●
●
●
●
●
●
● ● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●●
●
●●
●
●
●
●●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
�