pseudo1 n1b4 set1it001 #1 (gmed=44 rho12=0.039)...
TRANSCRIPT
-
●
● ●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●●
●
●
●●
●●
● ●
●
●
●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●●
●
●
●●
●●
●●
●
●●
●
●
●
●
●
● ●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●●
●
●
●●
●●
●
●●
●●●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●
●● ●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●●
●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
● ●
● ●
● ●
●●●
●
●
●●
●●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●●
●
●●
●● ●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●●
●
●●
●
●
●
●●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●●
●●
●●
●
●
●
●
●
● ●
●●
●
●
●
●
●
●
●
●
●●
●
● ●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●●
●
●
●●
●
●
●●●
●
●
●●
●●
●
● ●
●
●
●
●●
●
● ●●
●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●●●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
● ●
●
●●●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
● ●●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●●
● ●
●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
● ●
●
●
●
● ●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
●
● ●
●
●
●
−1.5 −1.0 −0.5 0.0 0.5 1.0
−1.
5−
1.0
−0.
50.
00.
51.
0pseudo1_N1B4 set1IT001 #1 (gMed=44 rho12=0.039)
Time0
First Half
Sec
ond
Hal
f
-
●
●●
●●●
●●
●
● ●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
● ●
●
●
●
●
●
●● ●
●
●
●
●
●
●●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●●
●
●
●
●
●
●●
●●
●●●
●
●
●
●
●●
●●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●●●
●
●
●
●●
●●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●●
●
●
●
●● ●
●
●
●
●
●●
●
●
●●
●●
●●
●
●
●
●●
●●
● ●
●
●
●
●●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●
●
● ●
●
●●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●●●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●●
●●
●●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
● ●
●
●
●
●●
●●
●
●
●
●●
●
●
●●
●
●
●●
●
●
●
●
●●
●
●●
●
●●●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●●
●
●●
●
●
●
●
●
●
●
● ●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●●
●● ●
●●
●
●
●
●
●●
●
●
●
●
●
●
●●● ● ●
● ●
●
●
●
● ●
●
●
●
●
●●
●●
●
●●
●
●
● ●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
● ●
● ●
●●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●●●
●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●●
● ●
●
●
●
●●●
●●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
● ●
●●
●
●●
●
●
● ●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●● ●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
● ●
●
●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
● ●
●
●
● ●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
● ●●
●
●
●
●
●●
●●
●
●
●
● ●
●
●
●●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
● ●
●
●
●●●
●
●
●
●●●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●●●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●●
●
●
●
● ●
●
●
●
●●
●●
●
−1.0 −0.5 0.0 0.5 1.0
−1.
0−
0.5
0.0
0.5
1.0
1.5
pseudo1_N1B4 set1IT002 #2 (gMed=51 rho12=0.005)Time0
First Half
Sec
ond
Hal
f
-
●●●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●● ●
●
●
●
●
●●●
●
●
●
●●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●●
●
●●
●●
●
●
●●
●
●●
●●●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●●
●●
●
●
●
●
●●
●●
●
●
●●
●
●
●
●
●
●
●
●●
●●
●●
●●
●
●
●●
●●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●
●
●
●●
●
●
●●
●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●●
●●
●●
●●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●●
●●
●
●
●●●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●●
●●
●
●
●●
●
●●
●
●
●
●● ●●
●
●
● ●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●●
●
●
●
●
●
●
●
●●
● ●●
●
●●
●
●●
●
●
●
●●
●
●
●
●
●●
●●
●
●●
●
●●
●
●
●
●
● ●
●
●
●●
●
●●
●
●
●●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●●
● ●●
●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
● ●
●
●
●●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
● ●
●
●
●
●●
●●
●
●
●
●●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
● ●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
● ●●
●
●
●
● ●●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
● ●
● ●
●
●
●
●
●
● ●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
● ● ● ●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ● ●●●
●
●
●
●
●
●●
●
●
●
●
●
●●
●●
●
●
●●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
● ●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
● ●●
●
●
●
●●
●
●●
●
● ●
●●
●
●
●
●
●
●
●
●●
●
●● ●
●
●
●
●
●●
●●●
● ●
●
●
●
●
●●
●●●
● ●●
●
−1.0 −0.5 0.0 0.5 1.0
−1.
5−
1.0
−0.
50.
00.
51.
0pseudo1_N1B4 set1IT003 #3 (gMed=55 rho12=−0.003)
Time0
First Half
Sec
ond
Hal
f
-
●●
●
●
●
●●
●
●
●●
●
●●●
●
●●
●
●● ● ●
●
●●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●●●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●
●
●●
●●
●●●
●
●
● ●●
●
●
●
●●
●
●
●●
●●
●
●
●●
●
●●
●
●● ●●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●●
●
●
●●
●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●
●
●
●●
●
●
●
●
●
●
●
●●
●
●●
●
●
●●
●
●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●●
●●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●●● ●
●
●
●●
●●
●
●
●●
●
●●●
●●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●
●
●
● ●●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ● ●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●
●
●●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●● ●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●● ●
●
● ●
●
●●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
● ●
●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●●
●●
●
●
●
●
●
●
●●
●
● ●
●
●●
●
●
●
●●
●
●
●●
●
●●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●●
●● ●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●●
●
●●
●
●
●
●
●
●●
●
●
●
●●
●
●
●● ●
●●●
●
●
●
●
●●
●
●●
●
●●
●●●
●●
●●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
● ●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●●
●●● ●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●●
●
● ●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
● ●●
●●
●●
●●
●
●
●
●●
●
●●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
● ●●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●●
●● ●●
●
● ●
●
●
●
●
●
●
●
●●
●●
●
●
●●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●
●
● ●●
●
●●
●
● ●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
● ●
●●
●●
●●
●
●
●●
● ●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●●
●●
●
●
●●
● ●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●●
●
●
●
● ●
●●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●
●
●●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●●
●
●
●
● ●
●
●●
●
●●
−1.5 −1.0 −0.5 0.0 0.5 1.0
−2.
0−
1.5
−1.
0−
0.5
0.0
0.5
pseudo1_N1B4 set1IT004 #4 (gMed=49 rho12=−0.003)Time0
First Half
Sec
ond
Hal
f
-
●
●
●
●
●●●
●
●●
●
●
●
●
●●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●
● ●●
●
●
●●
●
●
●
●
●
●
●
●
●● ●
● ●●
●
●
●
●
●
●
●●●●
●
●●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●●●
●
●
●●●
●
●●
●●
●
●
●
●
●
●
●
●
●
●
●●
●●●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●● ●
●●●
●
●●
●● ●
●
●
●
●
●
●●●
●
●
●
●
●●
●
●
●●
●
● ●
●
●
●●
●
●
●
●●
●
●●
●●
●●
●
●
●●
●
●
●
●●●
●
●
●
●●
●●●
●●
●
●
●
●
●
●●
●
●●●
●
●
●
●●
●
●●●
● ●●
●●
● ●
●
●
●
●●
●●
●●
●●
●●●
● ●
●●●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●●
●●
●
●●
●
●
●
●●
●●● ●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●●
●
●
●●●●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●
●●
●●●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●
●
●
●
●
●●
●
●●
●
●●
●
●●
●●
●
●
●●●
●
●
●
●
●●
●
●
●
● ●●
●
●
●
●
● ●
●●●
●
●
●●●●
●●
●
●
●
●
●
● ●
●
●
●
●● ●
●●●●
●●
●
●
●
●●
●●
●
●
●●
●
●●
●●
●
●
●
●
●
●●
●
●
● ●●
●● ●
●
●●●
●
●
●●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●● ●
●
●
●
● ●
●●
●
●●
●●●
●
●
●
●
● ●
●
●
●
●● ●
●
● ●
●
●
●
●●
● ●●
●
●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●●●
●
●
●
●
●●
●
●
●
●●
●
● ●● ●
●
●●
●●
●
●
●
●●●
●
●
●●
●
●●
●●
●
●
●
●●
●●
● ●●
●
●
●
●
●
●●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●●
●
● ●
●
● ●
●
●●●
● ●
●
●●
●
●
● ●
●●
●
●● ●●
● ●●●
●●
●●
●
●
●●
●
●
●●
●
●●
●
●●
●
●
●
●
●
●●
●
●
●●
●
●●●
●
●
●
●
●●
●
●
●
● ●●
●●●
●● ●●●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
●●
●
●
●●
●●●
●
●
●
●
●
●
●
●
●
●
●
●● ●
●●
●
●
● ●
●
●
●
●
●
●
● ●●
●
●
● ●
●
●
●●● ●● ●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●
●
● ●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
●
●●●
●
● ●
●
●
●●
●
●●
●
●●●
●●
●
●●
● ●● ●
● ●●
●
●●
●●
●●
●
●●
●●
●●
●
●
●●
●
●
●
●
●
●
●●●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●●
●
●
●
●
●
●
●●
●●
●
●●●
●●●
●
●● ●
●
●
●
●●
●●
●
●
●●
●
●
●
●●
●
●
●
●
●●
●
●
●●
●● ●●
●
●
●
●
●●
●
●
●
●
●●●
●●
●
●
● ●●
●
●●
●●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
●
●●●
●
●
●
●
●
●
●
●
●●
●●
●●●
●
●
●
●
●
●
●
●
● ●●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●●●
●●
●
●●
●
●
●
●
●●●
●
●
●●
●
●
●●
●
●
●
●
●● ●
●●
●
●●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●●●
●
●
●●●●●
●●
●
●
●
●
●
●
●
●
●●
● ●
●
●
●●
●●
●
●●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
● ●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●●
●●
●
●
●
●
●
●
●● ●
●●●
●
●
●
●●
●
●●
●
●
●
●
●
●
●
●
●●
●
●
●●
●●
●
●
●
● ●●
●
●
●
●●
●
●
●
●
●●
●●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●
●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●
●
●
●
●●●●
●
●
●●●
●
●
●●●
●
●
●
●
●
● ●
●
●
● ●
●
●
●
● ●
●
●●
●
●
●
●
●●
●
●
● ●
●
● ●
●
●
●●
●
●
● ●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●
●
●●
●
● ●●
●
●●
●
●
●
●
●
●
●
●
●
●●
●● ●●●
●●
●
●
●
●
●
●
●
●
●●●
● ●●
●
●●
●●
●●
●
●
●
●
●
●
●
●
●●
−4 −3 −2 −1 0 1 2
−3
−2
−1
01
2pseudo1_N1B4 set1IT005 #5 (gMed=52 rho12=0.177)
D−Glucose (C)
First Half
Sec
ond
Hal
f
-
●●●
●●
●●●
●
● ●● ●●
●
● ●
●
●
●
●
●
●
●
●
●●
●●
●●●
●
●
●
●●
●●
●
●●
●
●●
●●
●
●
●●●
●
●●
●
●
●
● ●
●●
●● ●
●●
●
●
●
● ●
●
●
●
●
●
● ●
●
●●
●
●
● ●●
●●
●
●●
●
● ●
●
●●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●●●
●
●●
●●
●●
● ●●
●●
●
● ●
●●
●
● ●
● ●
●●
●
●
●
●●●
●
●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●●●●
●●
●
●
●
●
●
●
● ●● ●
●
●
●
●
●
●●
●
●
●●
●
● ●●
●
●
●●●●
●
●●●
●●
●
●
●●
●●
●
●●
●
●
●
●
●●● ●
●●
●
●●●
●
●
●
●●
●
●
●
●
●●
●
● ●
●
●●
●
●
●
●
●●● ●●
●
●
●●
●
●●
●●●
●
●
●
●
●
●●
●●
●●
●
●
●●
●●
●
●●
●
●●
●
●
●
●
●
●●
●●●
●
●
●●●●
● ●
●
●●
●●●●●●●
●
●
●●
●●● ●●
●
●●
●●
●●
●●
●
●
●
●●●
●●
●
●
●
● ●
●●
●
●
●●
●●● ●
●
●
● ●
●●
●
●
●
●
●
●●
●
● ●
●
●
●
●●
●●
●
●
●
●
●
●
●
● ●●● ●
●
●
●
●
●
●
●
●●
●●
●
●●●
●
●
●
●
●●
●
●
●
●
●●
●●
●
●
●●
●●
●● ●●●
●
●
●
●
●●●
●
●
●
●
●●
●●
●
●
●● ●●
●
●
●
●
●
●
●
●●
● ● ●
●
●●
● ●●●
●
●
●●●
●●●
●
●
●
●●
●
●
●
●
●●
●●
● ●●
●
●
●
● ●
●
●
●●
●
●
●
●
●
●
● ●
●
●●
●
●● ●
●
●● ●
●●
●
● ●
●
●
●
●●●
●
●
●●● ●
●
●
●
●
●
●
●●
●
●
●●
●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
● ●●●
●
●●
●
●
●
●●
●
●
●●
●●
●
●
●
●
●● ●
● ●
●●
●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●
●
●●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
●●●
●●
●
●●
●
●
●
●
●●
●●
● ●
●
●
●
●
●
●●
●●
●
●
●
●
● ●
●
●
●
●
●●
●●
●
●
●●●
● ●●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●●
●
●
●
●
●●
●
●
●
●
● ●
●●
●
● ●
●
●●●
●●
●
●●
●● ●
●
●
●
●●
●●
●●
●
●●● ● ●●
●
● ●
●
●●
●●●
●
●●●●
●●
●●●
●
●
●
●
●
●
●
●
●●
● ●●
●●●●
●
●
●
●
● ●
●●
●
●
●
● ●●●●●
●
●
●●
●
●●
●
●
●●
●●●●
●●
●
●●
●
●
●
●
●●
●●●● ●●
●
●
●
●
●
●●
●
● ●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●● ●
●●
●●●
●
● ●
●
●
●●
●●
●
●
●●
●
●
●
●
● ●
●
●
●
●●
●
●
●●
●
●●
● ●
●
●
●
●
●●
●
●●●
●
●●
●
●
●● ●●
●
●●
●
●
●
●● ●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●●
●
● ●
●
●
●
●●
●
●●
●
●
●
●
●
●●●
● ●
●●
●
●● ●
● ●
●
●●
●
●
●
●
●
●●●
●
●●
●●
●
●
●
●●
●
●
●
●
●
●
●●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●●●
●
●●●
●
●
● ●
●
●●
●
●●
●
●
●
●
●
●●
●
●●
●
●
●
●
● ●●●●
●
●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
● ●
●●
●●
●●
●
●
●
●
●
●
●
●
●
●
●
● ●
●●
●●
●
●●
●
●
●
●●
●
●●
●●
●●
●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●●
● ●
● ●●
●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●●●
●
●●
●
●
●
●●
●
●
●
●●
●●
●●●
●
●
●●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●●
● ●●
● ●●●
●
●●
●
●●●
●
●●
●
●
● ●
●
●
●●
●
●
●
●●
●
●
●
●
●
●
●
●●
●
●
●
●
●●●
●
●
●
●
●
● ●
●
●
● ●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●
●
●
●
●●
●
●
●●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●
●●
●
●
● ●
●
●
●
●
●
●
● ●
●●
●●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●●
●
●●●
●●
●
●
●
●
●
●
●●
●●●
●
●
●
●
●
●
●●
●
●
●●
●●
●
●●
●
●
●●●
●●
● ●
●
●
●
●
●
●
●●
●
●
●
●●
●● ●
●
●
●●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●
●●
−3 −2 −1 0 1 2 3
−3
−2
−1
01
23
pseudo1_N1B4 set1IT006 #6 (gMed=60 rho12=0.294)D−Fructose (C)
First Half
Sec
ond
Hal
f
-
●
●●
●●●
●●
●
●
●
●●
●●
●●
●
●
●●
●●
●
●
●
● ●
●●
●
●●
●●●
●
● ●●
●
●
●
●●
●●
●
●●
●●● ●
●
●●
●
●
●●
●●
●
●●●
●
●●●●
●
●●
●
●●
●●
●
●●
●
●
●●
● ●●
●
●
●● ●
●
●
●●
●
●
●
●
●●
●
●
●●●
●
●
●
●
●
●
●
●
●●●●
●● ●●
●
●●
●
●
●●
●
● ●
●●●
●
● ●
●
●●
●
●●
●
●●
●
●
● ●●●
●
●
●●● ●●
●
●●
●
●
●
●●
●
● ●●
●
●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●● ●●
●
●
●
●●
●
●
●
●
●●
●
●
●
●
●●
●
●●
●● ●●●
●
●
● ●●
●
●
●
●
●
●
●●
●
●
●● ●●●
●●
●●
●
●
●
●
●●
●
●●●
●
●●
●
●●
●
●●
●
●●
●
●●
●●
●
●
●●
●
●
●
●
●●
●
●
●
●
●
●●
●
●
●
●●●
●●
●●●●
●
●
●
●
●●
●
●●
●
●
●
●
●
●
● ●
●
●
●●
●
●
● ●
●
●
●●
● ●●
●
●
●
●●
●
●
●
●
● ●●
●
●
●
●●
●
●
●
● ●●
●
●●
●
●
●
●
●
●
●●
●
●●
●●
●
● ●
●● ●●
●●●
●●
●
● ●●●
●
● ●
● ●●
●●
●
●
●
●
● ●●
●
●●
●
●●
●●
●
●
●
●
●●● ●
●
●●
●
●●
●●
●
●●
● ●
● ●
●● ●
●
●
●
●
●●
●●
●
●
●●
●●
●●
●●●
●
● ●
●
●
●●
●
●
●●●●●
●
●
●
●●●
●● ●
●
●
●
●
●
●
●●●
●
●
●
●●
●●
●● ●
●●
●●
●●
●
●
●
●
●
●●
●
●
●
●
●●
●●●
●●
●
●
●
●
●
●
●
●●
●●
●
●
●●
●
●
●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●●●
●
●
●●
●
●●
●
●
●●
●
●
●
●
●
●
●
●
●
●●
●
● ●●
●
●
●
●
●
●
●
●
●
●●
●
●
●●●
●●●
●
● ●●
●●
●
●
●
●●
●
●●
●
●
●
●●
●
●
●
●●
●
●
●●●
●
●
●
●
●
●●
●
●●●
●
●
●
●
●
●
●
●
●
●
●
●●
●
●
● ●
●
● ●
●●
●
●
●
●
●
●
●●
●●●
●
●●
●●
●
●
●●
●●
●
●
●
●
●●●
●●
●
●●
●
●
●
●
●
●
●
●
●
●
●●●
●
●
●●
●●
●●
●
● ●●
● ●●
●●
●●
●
●
●
●
●
●●
●
● ●
●
●● ●
●
●●
●
● ●
●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●● ●●●●
●●●
●
●
●
●
●
●
●
●
●
●●
●●
●
●
●
●
●
●
● ●●
●
●
● ●
●
●●●
●●
●
●●
●●
●●
●
●
●
●
●
●
●
●● ●
●
●
● ●
●
●
● ●
●●
●
●
●●●●
●
●
●
●
●
●
●● ●
●●
●
●
●
●
●●●
●
●
●●
●
●
●● ●●
●
●● ●●
●●
●
●
●●
●●
●●●
●
●
●●
●
●
●
●
●●
●
●
●
●●
●●
●● ●●●● ●
●
●
●●● ●
●
●
●
●●
● ●
●
●●● ●●
●●
●
●
●
● ●
●
● ●
●●
●●
●●
●
●●●●
●
● ●●
●●
●
●
●●
●●●
●
●
●●
●●
●
●
●
●●
●
●
●
●
●●
●
●
●●●
●
●
●●
●
●●
●●
●
●
●
●
●●
●
● ●●●
●
●●
●●
●●●
●
●
●
● ●
●●
●
●
● ●●
●
●
●
●●
●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
● ●● ●
●
●
●●●
●
● ●
●●●●
●
●
●
●
● ●
●
●●
●●
●
●
●
●
●
●●●
●
●
●
●
●
●
●●
●
●
●
●
● ●●
●
●
●
●
●●●
●
●
●
●●●
●
●●
●
●
●●● ●
●
●
●
●●●
●
●
●
●
●
● ●●●
●
●
●
● ●
●
●
●
●
●
●
●
●
●●●
●
● ●
● ●
●
●● ●
●●
●
●●
●
●
●●
●
●
●
●●
●
●
●
●●●
●
●
●●
●●
●
● ●●
●●
●●
●●
●
● ● ●
●
●
●
●
● ●
●●●
●
●
●
●
● ●
●
●
●
●●
●●
●
●
●●
●
●●●
●
●●
●
●
●
●
●
●
●●●●
●
●
●
●●
●
●
●
●●●
●
●● ●
●
●
●
●
●●
●
● ●●● ●
●●
●●
●
●●
● ●●●
●
●
●
●
●
●
●
●
● ●
●
●●● ●
●●●
●
●●
●
●
●●
●●
●
●
● ●●●●
●
●
●
●
●
●
●
●
●●
●
●
●
●
●
●
●●
●●
●●●
●
●
●
●
●●
●●
●
●
●●
●
●●●
●
●
●●
●●
●●
●
●●●●●
●●
●●
●●●
●
●
● ●
●
●
●
●
●
●
●
●●
●
●
● ●
●
●●
●
●
●
● ●
●
●● ●
●
●
●●
● ●
●●
●●
●
●
●