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DNA Mutations and Repair Chapter 17

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DNA Mutations and Repair. Chapter 17. Detecting mutations with the AMES test. SUMMARY OF AMES TEST. AMES TEST. Saccharin Aflatoxin. 2-aminofluorene. Aflatoxin B1. DNA Repair: general characteristics. Double stranded DNA Redundancy of pathways. Types of DNA repair. Mismatch repair - PowerPoint PPT Presentation

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Page 1: DNA Mutations and Repair

DNA Mutations and Repair

Chapter 17

Page 2: DNA Mutations and Repair

Detecting mutations with the AMES test

Page 3: DNA Mutations and Repair
Page 4: DNA Mutations and Repair

SUMMARY OF AMES TEST

Page 5: DNA Mutations and Repair

AMES TEST

• Saccharin

• Aflatoxin

2-aminofluorene

Page 6: DNA Mutations and Repair

Aflatoxin B1

Page 7: DNA Mutations and Repair

DNA Repair: general characteristics

• Double stranded DNA• Redundancy of pathways

Page 8: DNA Mutations and Repair

Types of DNA repair

• Mismatch repair

• Direct Repair

• Base-Excision Repair

• Nucleotide Excision Repair

Page 9: DNA Mutations and Repair

Mismatch repair

• Mut H– Recognize GATC hemi-methylation

• Mut S• Mut L

Page 10: DNA Mutations and Repair

A closer look at mismatch repair

Page 11: DNA Mutations and Repair

Direct Repair

DIRECT REVERSAL REPAIR

Page 12: DNA Mutations and Repair

BASE EXCISION REPAIR

Page 13: DNA Mutations and Repair

BASE EXCISION REPAIR

Page 14: DNA Mutations and Repair

Nucleotide Excision Repair

Page 15: DNA Mutations and Repair

Diseases of DNA repair!

Page 16: DNA Mutations and Repair

Xeroderma pigmentosumAutosomal recessive

Page 17: DNA Mutations and Repair

Hereditary Non-Polyposis Colon Cancer

• HNPCC

• 15% of all colon cancers

Page 18: DNA Mutations and Repair

Li-Fraumeni

• P-53 mutation

Page 19: DNA Mutations and Repair
Page 20: DNA Mutations and Repair

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