dna-repairing protein may be key to preventing recurrence of some cancers and a scanner for...
TRANSCRIPT
Paula E. Montoya
Medical student
III semester
Lina María Martínez Sánchez
Molecular Biology
DNA-Repairing Protein May Be Key to
Preventing Recurrence of Some
Cancers and A Scanner for Hereditary
Defects: New Possibilities in Genetic
Damage
Recognition for Improving Cancer
Treatment
INTRODUTION
• When the cell have a faultysystem to repair damaged DNAis when we start to have aserious problems like cancer .
• Also the repair system whencell become in cancer cell aswell have a repair system thatagainst treatment
A SCANNER FOR HEREDITARY
DEFECTS: NEW POSSIBILITIES IN
GENETIC DAMAGE RECOGNITION FOR
IMPROVING CANCER TREATMENT (JAN.
24, 2013)
• Our DNA are constantlyrepair himself for all thethings that attack him, howfrom outside (UV light andtoxins) and inside ( metabolicprocess)
• This repair system is a processthat have a lot importance forthe normal functionality of thecell
A SCANNER FOR HEREDITARY DEFECTS: NEW
POSSIBILITIES IN GENETIC DAMAGE RECOGNITION
FOR IMPROVING CANCER TREATMENT (JAN. 24, 2013)
• When this system don’t recognized andrepair damage genetic material can causecancer or genetic disorders.
• Hanspeter Nägeli and his team discoveredprotein XPD find damage genetic material ,what makes this protein very important inthe study of DNA.
Find Mark Repair
“The XPD scanner (green)is in close contact with
a damaged point (red) on the DNA double helix.
The damaged DNA strand lies in a deep pock et
of the protein to enable a ferrous sensor (Fe) to
come into contact with the damaged point,
thereby halting the protein as it moves along the
DNA. (Credit: Picture:UZH)”
A SCANNER FOR HEREDITARY DEFECTS: NEW
POSSIBILITIES IN GENETIC DAMAGE RECOGNITION
FOR IMPROVING CANCER TREATMENT (JAN. 24,
2013)
• XPD protein as scanner:
The genetic information
is stored on DNA double
helix. This protein works
like a scanner looking
signs of damage. When
find this protein stop and
marks where needs repair
the DNA
• This mechanism is veryimportant because protecthealthy tissue and repair theDNA.
• But have a impact insubstances against cancer it,this helps , cause canstimulate or suppress thisprotein depends ofrequirements (used in therapy)
Basis for possible courses of therapy
A SCANNER FOR HEREDITARY DEFECTS: NEW
POSSIBILITIES IN GENETIC DAMAGE RECOGNITION
FOR IMPROVING CANCER TREATMENT (JAN. 24,
2013)
• PERSONAL OPINION :
Every body cell has specific functions,but they all have a lot in common process,cellular repair is one of them, with veryimportant because I think it's crucial tohave a functional balance of the cell; findthese proteins and know their functionwithin the I think the process is a majorbreakthrough in the field, but whatfollows so you can take one beyond whatyou will find will set the pace for thefunctionality of this protein as a cancertherapy.
A SCANNER FOR HEREDITARY DEFECTS: NEW
POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR
IMPROVING CANCER TREATMENT (JAN. 24, 2013)
DNA-Repairing Protein May Be Key to
Preventing Recurrence of Some
Cancers (Jan. 28, 2013)
Antibiotics , methods of killing cancer tumors -body resistant
University of Central Florida professor has
found a protein
present in several types
Like breast and ovarian cancer
This is important cause can
preventing tumors coming back
KLF8 protein
(appears to
protect tumor cells)
DNA-Repairing Protein May Be Key to
Preventing Recurrence of Some Cancers
( Jan. 28, 2013)
• All our cells can repair her DNA by important
mechanisms ; thanks that the DNA can face
constants damage threats.
• The KLF8 is in specific cancers : such breast and
ovarian cancer.
• If they can stop his activity maybe they can stop
cancer recurrence and use this as therapy against
the cancer.
DNA-Repairing Protein May Be Key to
Preventing Recurrence of Some Cancers
( Jan. 28, 2013)
• The therapy that damage of DNA of cancer cells depends the capacity of this cells of repair himself .
High levels of DNA repair
Increase resistance of the
cells to such therapies
Increase improper DNA repair-mediated
Increase the malignancy of the
cells
DNA-Repairing Protein May Be Key to
Preventing Recurrence of Some Cancers
( Jan. 28, 2013)
KLF8-promoted DNA repair to the cell resistance to
doxorubicin-induced cell death
KLF8 have a role: repairing DNA damage cause by other
types of genotoxic.
This protein do a disturbing genomic integrity and contribute
aggressive progression.
DNA-Repairing Protein May Be Key to
Preventing Recurrence of Some Cancers
( Jan. 28, 2013)
• PERSONAL OPINION:
Not only know the properties of our cells as therapy isthe key but , if not that, to know who we are fightingagainst, it is very important to improve the waytreatment it , which is why I find this news importantbecause it deals with every day situations whichincrease in our society as the news says "There areBetween 2.5 million and 2.7 million Women who HaveBreast Cancer in the United States and 10 to 20percent will experience a recurrence" a percentage thatsuch research may decrease.
MEDICAL UTILITY
• Research and update always will bevery important in the areaof medicine, as this can be at theforefront on issues is increasinglyboom in the middle regarding diseasesand treatment of these.
• the importance of knowing how
work our body , understand and
thus achieve better treatment.
MEDICAL UTILITY
• Our body is constantly changing andsometimes can not keep up and that iswhere we improve this adaptation.
MEDICAL UTILITY
• XPD protein as scanner and KLF8protein, that help us betterunderstand the system of cellularDNA repair and use it in thisadaptation .
MEDICAL UTILITY
BIBLIOGRAFIA
1. Martínez Sánchez LM, Vargas Grisales N, Toro Montoya AE. Biología molecular. 7 ed. Medellín: UPB. Fac. de Medicina, 2012. p 85-101.
2. A Scanner for Hereditary Defects: New Possibilities in Genetic Damage Recognition for Improving Cancer Treatment ,Jan. 24, 2013 from [internet] http://www.sciencedaily.com.
3. DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers, Jan. 28, 2013, from [internet] http://www.sciencedaily.com.
THANKS
• “If we knew what it was we were doing, it would not be called research, would it?”
• ― Albert Einstein