does knowing personal genomic information change behavior?
DESCRIPTION
Does knowing personal genomic information change behavior?. Nate Cira Gene 210 6/5/2012. Importance. Are there benefits to testing? Are there risks from testing? Should people be tested? Should tests be regulated? Relation to other medical risk factors?. Class Related Anecdotes. - PowerPoint PPT PresentationTRANSCRIPT
Does knowing personal genomic information change behavior?
Nate CiraGene 2106/5/2012
Importance
• Are there benefits to testing?• Are there risks from testing?• Should people be tested?• Should tests be regulated?• Relation to other medical risk factors?
Class Related Anecdotes
• Robin Starr– Breast cancer
• Rosalind Chuang– Denial and Insistence
• Steve Quake– Statins
Single Alleles
• 35 article review• Including colorectal cancer, Alzheimer’s,
breast and ovarian cancer• Short term distress and anxiety• Slightly increased screening• Perceived risk increases then returns to
noncarrier by a year
Heska et al. Genetics in Medicine. 2008
Scripps StudyNavigenics test6 month follow-up~2000 surveyedLarge dropout
Bloss et al. NEJM 2011
Keyan’s survey
• Initial 210 class• Found better learning in those genotyped• Submitted for publication
This year’s survey: Population
• Population• 19 responses• 16 were genotyped/3 were not• 9 female/10 male
Behavior: Exercise
Decreased No change Increased02468
10121416
0
14
1
Did you change your habits as a result of learning your genomic information with
regard to exercise?
Behavior: Diet
Worsened No change Improed02468
1012141618
Did you change your habits as a result of learning your genomic information with
regard to diet?
Behavior
Researched a c
ondition
Sough
t medica
l advic
e
Sough
t additional
testing
048
1216 14
0 0
Which of the following did you do as a result of learning your personal genomic
information?
Outlook: Non-health
No Change
Change
d Somewhat
Change
d Sign
ificantly
02468
1012 10
6
0
Did knowing genetic information change your outlook on non-health re-
lated aspects of your life?
Outlook: Health
No chan
ge
Change
d Somewhat
Change
d Sign
ificantly
02468
1012
5
11
0
Did knowing your genomic information change your outlook on your peronal
health?
Outlook: Anxiety
Less
anxio
us
Somewhat
less an
xious
No chan
ge
Somewhat
more anxio
us
More anxio
us02468
1012
0
3
11
20
Has knowing your genomic information changed anxiety in your life?
Sharing
Doctor Genetic Counselor
Friends Family Gene210 Classmates
02468
1012141618
10
13
16
7
Who did you share your genomic in-formation with?
Anticipation
Nervous Excited Calm0
2
4
6
8
10
12
14
6
13
1
When you first opened your results were you?
Engagement
Less
engage
d
Smewhat
less enga
ged
Equally e
ngage
d
Somewhat
more engage
d
More engage
d0
4
8
12
0 0 0
13
3
How has your engagement been influenced by knowing your personal genomic infor-
mation?
Pressure
Yes No02468
101214161820
1
18
Did you feel pressured to be genotyped?
Yes No02468
1012141618
0
16
Did you feel pressured to nonanonomously share genomic infor-
mation?
Genotyping
Yes No0
2
4
6
8
10
12
14
16
1816
0
Would you recommend others be genoyped?
Conclusions
• Sample size• Self-reporting• Short term• Links between gender and anxiety• Representative?• Other medical risk factors?
Questions
?
Thoughts
• Bias against improved health and exercise• Might in future insist on extra testing• Small sample size• Self reporting• All people changing anxiety were female
• 'Does knowing personal genomic information change behavior?' - Why is this question important - Studies on single alleles (BRCA, ect.) - Scripps study and associated literature - Keyan's survey - Anecdotes from Robin, and Steve Quake - Results from my survey - Summary and concluding remarks