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DOGMA 

SENTRALBIOLOGI

MOLEKULERRiandini 

Aisyah

Molecular  

Biology 

& 

Immunology

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Figure 

4-9 Molecular  Biology  of  the Cell(© 

Garland  Science 2008) LOGO www.themegallery.com

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The 

center  

information 

storage 

in 

cell

ALL SECRETS OF LIFE

“BRAI! 

" 

of  

all 

cells 

is 

#A

If  

$e 

can 

re%eal 

the 

eact 

form 

of  

our  

genetic 

'lue(rint 

$e 

shall 

ha%e

ta)en a giant ste( to$ard understanding the many com(le set of 

interconnected 

chemical 

reactions 

in 

an 

organism

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One gene " one (rotein

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#A RA *rotein

+Central #ogma,

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Central DogmaGene

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Protein

Transcription

Translation

Genome

Transcriptome

Proteome

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-u&.eng/ 

01203 

From 

S*s 

to 

SA*s3 

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Else%ier3

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Ro'inson 

et3al301243 

Current 

ad%ance 

in 

system 

Iintegrati%e

 

'iology3 

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56MA 7EOME 8 total geneticinformation

  NUCLEAR GENOME

* 

23 

pairs 

of  

chromosomes 

≈2 

 

! 

3 

 

"#$

%&p' ≈ 2 me(ers DNA ) Ce

* 

2 

 

! 

3 

 

"#"2 

' 

me(ers 

DNA 

i+ 

h,ma+%o-. 

≈ /0###  !ear(h (o moo+'

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LOGO 

Mt#A

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LOGO 

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www.themegallery.com

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ucleotides9

 

A 

" 

T

 

7 

" 

C

 

Sugar9

 

#e 

oy 

ri'ose  Ri'ose

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*hos(hate

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5o$ 

to 

understand 

gene 

functions 

:

 

Certain 

stimuli rece(tor  

signal transduction

intracell 

(ath$ay

nuclear  

res(onse

certain gene on

transcri(tion

RA

s(licing

m 

RA

translation

*rotein +a3a,

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+ ,

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Each 

gene 

 produces 

an 

RNA 

molecule

  The (rimary fuction of  the genome9 to s(ecify RAmol

 

The 

e(ression 

is 

regulated  

(rot3 

'ind 

to 

the 

#Ain regulatory regions to determine $hether  a gene is

transcri'ed

  coding and coding se<uences8 eon and intron

One gene " one (rotein

#A RA *rotein

+Central 

#ogma,LOGO 

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  RA " m  RA

t RA

r RA

  Fungsi RA

m  RA " transfer  information from genes to

(rotein " synthesi=ing machine

t RA " carries acti%ated a3a for  (rotein

synthetisr RA " (rotein synthesis

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  7EOME  9

Mus musulus 9 mammalia >321? '( #A

5omo sa(iens >3@ 21? '(

  7E +#A, AALSIS

RFL*  8 RESTRICTIO FRA7METLE7T5 *OL MOR*5ISM

*F7E  8 *6LSE# FIEL# 7EL ELECTRO*ORESIS

*CR 8 *OLMERASE C5AI

REACTIO

5BRI#ISATIO ORT5ER/ SO6T5ER

-ESTER   LOGO 

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#A 

  

7enes

 

eistence

 

multico(y

 rearrangement

 mutation

 

structural 

  

se<uence 

changesLOGO 

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RA  9

 

gene 

e(ression

 

le%el 

of  

e(ression

 

degradation 

time

 

gene 

function

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Thera(y in the future/ drug disco%ery

todayDD

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LOGO Lorio et al.2013. Gene to Screen. Review. Elsevier 

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in  ang et al3012@3ision from et

7eneration 

Se<uencing3 

Fig323 

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LOGO