dolen & malenka 2013
DESCRIPTION
Journal club for 2013 Nature article, "Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.TRANSCRIPT
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Kristen DelevichJournal Club 10/15/13
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Prairie vole Montane vole
Insel and Shapiro 1992
125I-OTA bindingOTR and pair-bonding
Photo: Todd Ahern/Emory University/via the San Francisco Chronicle
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How to make love like a prairie vole??
Kimberly A. Young, Kyle L. Gobrogge, Yan Liu, Zuoxin Wang 2011
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Love and other drugs
photograph copyright Jean-Louis Klein and Marie-Luce Hubert
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2013
2012
Complex role of Oxytocin signaling
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Do OTergic hypothalamic inputs to NAc even exist in male mice?
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Male mice receive substantial OTergic input from PVN but not SON
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Oxytocin is required for social CPP
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NAc delivery of OT-A sufficient to block social CPP
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Cocaine-induced CPP doesn’t require Oxytocin
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Oxytocin induces LTD onto NAcc MSNs
Allen Brain Atlas
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Social housing engages OT-LTD, OT-LTD targets D1 & D2 NAc MSNs
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Oxytocin-induced LTD is presynaptic
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Selective ablation of OTRs in cOTR mice
AAV-Cre
Rabies-Cre
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Presynaptic OTRs are required for social CPP
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OTR-expressing cells that project to NAc
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Ruling out vSub and ACC
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Dorsal-raphe presynaptic OTRs necessary for social CPP and OT-LTD
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NAc projecting dorsal raphe neurons are serotonergic
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OT-LTD acts through 5HTR1B 5H
T1R
B a
goni
st5H
T1R
B a
ntag
. + O
T
5HT
1R
B a
goni
st +
OT
ant
ag.
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5HTR1B antagonist in NAc blocks social CPP
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Circuit Summary
Downstream target?
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Mechanism?
2009