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** Digestive System **
Small/Large IntestineLiver
A&P Lecture NotesPages 98-103
Liver, Bile ducts, Pancreas and Small Intestine
2Figures from: Marieb, Human Anatomy &Physiology, Pearson, 2013
Three Parts of Small Intestine“Mixing bowl”; acid neutralization
Bulk of chemical digestion and nutrient absorption
Figure from: Hole’s Human A&P, 12th edition, 2010
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Main functions of small intestine: 1) chemical digestion 2) absorption of nutrients (90%) from chyme
occurs here
Vitamin B12 absorption
The ‘bowel’ consists of the small and large intestines.
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Blood Supply and Drainage of Small Intestine
4Figure from: Martini, Anatomy & Physiology, Prentice Hall, 2001
Wall of Small Intestine
Plicae circulares –permanent circular folds of mucosa that further increase surface area for absorption – do not flatten out with distention like rugae of
Figure from: Hole’s Human A&P, 12th edition, 2010
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distention like rugae of stomach.
Especially prominent in lower duodenum and upper jejunum
Submucosa of duodenum contains mucus-secreting glands (Brunner’s glands) that protect the small intestine
Intestinal Villi & GlandsFigure from: Saladin, Anatomy & Physiology, McGraw Hill, 2007 Enterocyte = Intestinal Cell
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Intestinal glands secrete an abundant watery fluid that helps absorb products of digestion. They also contain enteroendocrine cells (enterokinase, gastrin, secretin, CCK)
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Intestinal Epithelium
Microvilli further increase the surface area available for absorption in the small intestine
F ‘b h b d ’
Figure from: Hole’s Human A&P, 12th edition, 2010
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Form a ‘brush border’ on the intestine
Digestive enzymes are embedded in the membrane of microvilli
Main function of plicae, villi, and microvilli is to increase the surface area for absorption (from about 3.6 ft2 to about 2200 ft2!)
Secretions of Small Intestine• peptidase – breaks down peptides into amino acids
• sucrase, maltase, lactase – break down disaccharides into monosaccharides
• intestinal lipase – breaks down fats into fatty acids and glycerol
• enterokinase – converts trypsinogen to trypsin
Brush border
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• gastrin/somatostatin – hormones that stimulate/inhibit acid secretion by stomach
• cholecystokinin (CCK) – hormone that inhibits gastric glands, stimulates pancreas to release enzymes in pancreatic juice, stimulates gallbladder to release bile, and relaxes hepatopancreatic sphincter (of Oddi)
• secretin – stimulates pancreas to release bicarbonate ions in pancreatic juice; stimulates gall bladder to release bicarbonate-rich bile
See Table 23.32 in Marieb for a great summary of digestive enzymes
Movements of the Small Intestine
• peristalsis – pushing movements
• segmentation – ringlike contractions that aid in mixing and l i i t l i
Movements in local segments can occur without stimulation by parasympathetic NS. However, nervous stimulation accelerates segmentation and peristalsis.
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slowing peristalsis
• overdistended or irritated wall triggers “peristaltic rush” resulting in diarrhea
“Long distance” movements are triggered by stomach filling: - gastroenteric reflex (↑ motility and secretion along length of
small intestine)- gastroileal reflex (relaxation of ileocecal sphincter)
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Absorption in the Small Intestine
• monosaccharides and amino acids
• through facilitated diffusion and active transport• absorbed into blood
• electrolytes and water• through diffusion, osmosis, and active transport• absorbed into blood
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absorbed into blood
• vitamins• fat-soluble dissolve in dietary fats (vit A,D,E,K)•Water-soluble through diffusion, except B12 (active transport)• Vitamin K (large intestine) – with other lipids• absorbed into blood
Absorption of Fats in the Small Intestine
• fatty acids and glycerol
Figure from: Hole’s Human A&P, 12th edition, 2010
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g y• several steps• absorbed into lymph into blood
Chylomicrons contain TG, cholesterol, and phospholipids
Large Intestine
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Figure from: Martini, Anatomy & Physiology, Prentice Hall, 2001
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Histology of the Large Intestine
Walls of large intestine are much thinner than the small intestine, however, the lumen is larger
Figures from: Hole’s Human A&P, 12th edition, 2010
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Note lack of villi and presence of numerous goblet cells (mucus)
No enzymes produced; any digestion is from previously introduced enzymes or bacteria
Functions of Large Intestine• little or no digestive function
• absorbs water, bile salts, and electrolytes
• secretes mucus (lubrication, binding, protection, pH)
• conversion of bilirubin (uro- and stercobilinogen)
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• conversion of bilirubin (uro- and stercobilinogen)
• houses intestinal flora (~800 species of bacteria) and absorbs vitamins liberated by bacterial action (K, B5, and Biotin); produces intestinal gas (flatus)
• forms and stores feces
• carries out defecation
The Rectum, Anal Canal, and Anus
Temporary storage of fecal material in rectum triggers the urge to defecate
Internal anal
Rectal valves
Figure from: Hole’s Human A&P, 12th edition, 2010
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sphincter is usually contracted but relaxes in response to distension. External sphincter must be tensed reflexively to retain feces
(Keratinzed strat. squamous epithelium)
Procto- = anus or rectum
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Movements of Large Intestine
• slower and less frequent than those of small intestine
• mixing movements (haustral churning every 30 min)
• mass movements - usually follow meals (stimulated
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y (by distension of stomach and duodenum)
- gastrocolic reflex- duodenocolic reflex
- peristaltic wave from transverse colon through rest of large intestine
All You Need to Know???
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Parasympathetic Defecation ReflexFigure from: Saladin, Anatomy & Physiology, McGraw Hill, 2007
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Note that this reflex opens the internal sphincter and closes the external sphincter
Need voluntary relaxation of the external sphincter for defecation
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Feces• water (75%), solids (25%)
• electrolytes
• mucus
• bacteria (30% of solids) and sloughed epithelial cells
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• bacteria (30% of solids) and sloughed epithelial cells
• bile pigments altered by bacteria provide color (mainly urobilins and stercobilins)
• odor produced by bacterial compounds (indoles and skatoles, phenols, H2S, ammonia)
• indigestible materials
Major Organs of Digestive SystemFigure from: Saladin, Anatomy & Physiology, McGraw Hill, 2007
Organs can be divided into the:
-Digestive tract (primary)
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(alimentary canal); tube extending from mouth to anus (about 30 ft.)
-Accessory organs; teeth, tongue, salivary glands, liver, gallbladder, and pancreas
Liver [ Hepat(o)- ]
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Round ligament is part of the falciform ligament that divides the lobes; remnant of fetal umbilical vein.
Note that the vena cava does not enter the liver; it passes by
Figure from: Martini, Anatomy & Physiology, Pearson Education, 2004
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Arterial Supply and Venous Drainage of Liver
22Figure from: Martini, Anatomy & Physiology, Prentice Hall, 2001
Hepatic LobuleHepatic lobules are the functional units of the liver (>100,000)
23Figure from: Saladin, Anatomy & Physiology, McGraw Hill, 2007
Paths of Blood and Bile in Hepatic Lobule
Liver’s role as an accessory organ in digestion is production of bile
Figure from: Hole’s Human A&P, 12th edition, 2010
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Hepatic portal vein → sinusoids → central vein → hepatic veins → inferior vena cava
Hepatic artery
Sinusoid
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Liver Functions (over 200!)• Three general categories of function
1) Metabolic regulation• Interconversion of carbohydrates, lipids, amino acids
• Removal of wastes
• Vitamin and mineral metabolism
• Drug inactivation
• Storage of fats, glycogen, iron, vit A/B12/D/E/K Know items
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Storage of fats, glycogen, iron, vit A/B12/D/E/K
2) Hematological regulation• Phagocytosis and antigen presentation; ab removal
• Synthesis of plasma proteins
• Removal of circulating hormones
• Removal of worn-out RBCs (Kupffer cells)
• Removal or storage of toxins
3) Synthesis and secretion of bile (role in digestion)
in red
Composition of Bile (Chole-)
• water
• bile salts (bile acids) • derived from cholesterol • emulsification of fats (increases surface area for digestive enzymes)• helps absorption of fatty acids, cholesterol, and fat-soluble vitamins
Yellowish-green liquid continually secreted by hepatocytes
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• 80% are recycled (reabsorbed and reused) – enterohepatic circulation of bile• 20% excreted in feces (disposes of excess cholesterol)
• bile pigments (bilirubin and biliverdin from breakdown of RBCs)
• electrolytes
Gallbladder [Cyst(o)-]
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Figure from: Martini, Anatomy & Physiology, Prentice Hall, 2001
Main function is to store and concentrate bile between meals, and release bile under the influence of CCK
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Regulation of Bile Release from GBFigure from: Hole’s Human A&P, 12th edition, 2010
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• fatty chyme entering duodenum stimulates the GB to release bile (via CCK)
Secretin causes the bile ducts (and pancreatic ducts) to secrete bile rich in HCO3
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Actions of Cholecystokinin (CCK) on Digestion
CCKFigure adapted from: Barrett, K., Gastrointestinal Physiology, Lange, 2006
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Contraction of Gallbladder
Secretion of pancreatic enzymes
Reduced emptying of
stomach
Relaxation of hepatopancreatic
sphincter
Protein, CHO, lipid absorption and digestion
Matching of nutrient delivery to digestive and absorptive capability
Pancreatic Juice
• pancreatic amylase – splits glycogen into disaccharides
• pancreatic lipases – break down triglycerides
• pancreatic nucleases – digest nucleic acids
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• bicarbonate ions – make pancreatic juice alkaline (pH = 8) and neutralize acid coming from stomach
• Pancreatic proteolytic enzymes…