بسم الله الرحمن الرحيمبسم الله الرحمن الرحيم
GENUS: GENUS: YERSINIAYERSINIAProf. Khalifa Sifaw Ghenghesh
Yersinia pestisYersinia pestis
PlaguePlague Infected Fleas (Infected Fleas (Xenopsylla cheopisXenopsylla cheopis) )
are the Major Mechanism of are the Major Mechanism of
Transmission.Transmission.
Rodents >>Rodents >>
Clinical SyndromesClinical Syndromes
i. i. Bubonic PlagueBubonic Plague:: Incubation period: Incubation period:
– << 7 days after flea bite. 7 days after flea bite. High fever and painful bubo in the groin and High fever and painful bubo in the groin and
axilla.axilla. Untreated Untreated Bacteremia > 75% mortality Bacteremia > 75% mortality
raterate
ii. ii. Pneumonic PlaguePneumonic Plague:: Bubonic Disease >Pneumonic Plague > Bubonic Disease >Pneumonic Plague >
Exhales the Organism in Droplets.Exhales the Organism in Droplets.
Highly infectiousHighly infectious Incubation period:Incubation period:
– 2 to 3 days, with fever and malaise2 to 3 days, with fever and malaise– pulmonary signs within one daypulmonary signs within one day
Untreated Untreated > 90% mortality rate> 90% mortality rate
LABORATORY DIAGNOSIS
Aspirate from Buboes, Aspirate from Buboes, Pus from the Area of Flea Bite, Pus from the Area of Flea Bite, Sputum, Throat Swab or Blood.Sputum, Throat Swab or Blood.
Transport Media >>Transport Media >>
TREATMENT– StreptomycinStreptomycin
CONTROL– A Quarantinable Disease.– Control of Urban Plague:– Garbage Disposal.