DTL Partner Advisory Committee meeting
Utrecht, 13 November 2015
Professor in Personalized Healthcare Head Radboud Center for Proteomics, Glycomics and Metabolomics Coordinator Radboud Technology Centers Senior Scientist Integrator - Biomarkers
Prof Alain van Gool
• Nijmegen, The Netherlands
• Mission: “To have a significant impact on healthcare”
• Strategic focus on Personalized Healthcare through “the patient as partner”
• Core activities:
• Patient care
• Research
• Education
• 11.000 colleagues
• 52 departments
• 3.300 students
• 1.000 beds
Radboud university medical center
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Radboud campus: - Radboudumc - Radboud University - Hogeschool Arnhem Nijmegen - Max Planck Institute - Multiple companies
Orientation across the spectrum from molecule to man to population
Ori
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the
spec
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PI
Research Theme
Te
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C
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Research support by Technology
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Radboudumc Technology Infrastructure
Get organised:
1. What technological expertise do we have and should we have ?
2. How should we organise this ?
3. How will we communicate this ?
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External role
Internal role
• Knowledge hub for technological expertise • Maximise use of available technical capabilities and knowledge (‘duurzaamheid’) • Advise scientists with technological expertise • Advise management on strategic investments and opportunities • Drive innovations by working with each other, research theme’s and Valorisation
• Easy access to Radboudumc’s technological expertise • Represent Radboudumc as one in external technology networks • Increase funding (grants, contract research)
Internal / external role
Radboudumc Technology Centers
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Technology Platforms UMC St Radboud
(Potential) Technology Platforms
Genomics
RPC
CMBI PRIME
MIC
CDL
CRCN
Radboud Biobank Malaria lab
Flow cytometry
TR&CT
TNU
MITeC
PDRC
December 2013
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Inventory phase
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Radboudumc Technology Centers
Genomics
Bioinformatics Animal studies
Flow cytometry
Translational neuroscience
Image-guided treatment
Imaging
Microscopy
Biobank
Data stewardship
Proteomics Glycomics
Metabolomics
Radboudumc Technology
Centers
GMP products
Clinical trials
January 2014
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Repositioning phase
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Radboudumc Technology Centers Improving phase
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Feb-Oct 2014
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Radboudumc Technology Centers Improving phase
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Feb-Oct 2014
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www.radboudumc.nl/research/technologycenters
Genomics
Bioinformatics
Animal studies
Stem cells
Translational neuroscience
Image-guided treatment
Imaging
Microscopy
Biobank
Health economics
Mass Spectrometry
Radboudumc Technology
Centers Investigational
products
Clinical studies
EHR-based research
Statistics
Human performance
Data stewardship
Molecule
Flow cytometry
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Implementation phase
Nov 2014 -
About 250 dedicated people working in 18 Technology Centers, ~1600 users (internal, external), ~140 consortia www.radboudumc.nl/research/technologycenters/
• Proteins • Metabolites • Drugs • PK-PD
• Preclinical • Clinical
• Behavioural • Preclinical
• Animal facility • Systematic review
• Cell analysis • Sorting
• Pediatric • Adult • Phase 1, 2, 3, 4
• Vaccines • Pharmaceutics • Cyclotron • Radio-isotopes • Malaria parasites
• Management • Analysis • Sharing • Cloud computing
• DNA • RNA
• Internal • External
• Early HTA • Evidence-based
surgery • Field lab
• Statistics • Biological • Structural
• Preclinical • Clinical • Economic
viability • Decision
analysis
• Experimental design • Biostatistical advice
• Electronic Health Records • Big Data • Best practice
• In vivo • Functional
diagnostics
• iPSC • Organoids
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Visibility
• Logo
• Key figures • Website • Leaflets
• Lectures
Combination of • Science • Business • Innovation • Impact in health www.radboudumc.nl/research/technologycenters/
(1H2015: 1.900 unique visitors, 26.000 page views)
Users Radboudumc Technology Centers
Internal researchers (often with external collaborators)
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External researchers (direct collaborations, public-private)
External fee for service (public-private)
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Working together on the Radboud campus
(Spin-out) companies
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Radboud Research Facilities • Shared facilities across Radboud campus, also made part of Gelderland facilities • Initiated by funding 6.2M Eur Gelderland + 6.2M Eur Radboud University/ Radboudumc
www.ru.nl/radboudresearchfacilities/ 15
Working with other networks Region, nation, Europe, world
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Next steps
• Collaboration • Organisation of individual RTC’s • Interactions/collaborations/cross-selling between RTC’s • Research themes – Technology centers
• Networks • Local/regional/national/international
• Support • Cash, kind
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Use lessons learned for DTL?
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• Visualize DTL infrastructure 2.0 • Who, what, where? • Speciality? Quality? Accessibility? • Branding !! (eg. SciLifeLab)
• Define functional networks
• Coalition of the willing: based on mutual interest to collaborate (1+1=3) • E.g. Biobanks – facilities – data stewardship
• Funding should not be main driver
• Focus and get support • Define overarching theme and/or specialised focus areas
• E.g. Personalized Medicine & Health resp. Microscopy • Join forces in getting funding (NL (eg. NWO), EU (eg. ESFRI’s))
• Next steps
• Collaboration. Joined integrated D-T-L strategy. Focus. Action.
