Usage of IC in the bio/pharma industryCurrently Use
Not Sure
Do Not Use
68%
18%
14%
Ultraviolet(UV/Vis)
Conductivity Pulsed Amperometric
Detection (PAD)
Mass Spectrometry
(MS)
Fluorescence Evaporative Light
Scattering Detection
(ELSD)
Charged Aerosol
Detection (CAD)
Inductively Coupled
Plasma-MS (ICP-MS)
High Resolution MS
(HRMS)
Not Sure
38% 38% 33% 27% 22% 11% 9% 8% 8% 6% 11%
How do the bio/pharma industry use compendial monographs?
Use them as a minimum standard and stating point
Follow them word for word
Refer to the methods but don’t follow them
Planning to use them
Do not use them
Not Sure
Use them as a minimum standard and stating point
Follow them word for word
Refer to the methods but don’t follow them
Planning to use them
Do not use them
Not Sure
Are the bio/pharma industry familar with USP General Chapter <1065> ion Chromatography?
Yes No
18%
32%
31%
10%
6%3%
44%
56%
Modernizing pharmacopeial monographs with ICAnions and Cations in
a Drug FormulationAnions and Cations in
a Drug FormulationCurrent Monograph
Scenario
TOTAL # OF TESTS INVOLVED = 5 TOTAL # OF TESTS INVOLVED = 2
With the USP Modernization Initiative
Sodium
Potassium
Magnesium
Chloride
Acetate
Gluconate
Phosphate
Cationic IC
Cationic IC
Cationic IC
Anionic IC
Anionic IC
Anionic IC
Anionic IC
Flame photometry
Flame photometry
Atomic absorption
Titration with silver nitrate
Ion Exclusion Chromatography
Ion Exclusion Chromatography
Spectroscopic Procedure
More on Drug Monographs and Assays Using Ion Chromatographythermofisher.com/PharmaIC
Panel Discussion on Pharmacopeial Monograph Modernization and Ion ChromatographyRegister & Watch On-Demand Now
©2017 Thermo Fisher Scienti�c. All rights reserved. ST72591-EN 1217S
Application of Ion Chromatography in the Bio/Pharma Industry
In August-September 2017 an online survey was conducted by the Analytical Scientist (a Texere
Publication) on behalf of Thermo Fisher Scientific. The intent was to learn more about the application
of ion chromatography (IC) in the bio/pharmaceutical industry and the level of awareness and
applicability of pharmacopeial monograph modernization. The qualified responses collected in the
survey are the basis for the data shared in this infographic.
APIs/Drug Substances..
Counterions ... of API or Drug Sustance
Impurities/degradants...
Excipients and inactive formulation components
Monosaccharides and sialic acids
Amino acids (in biologics drugs)
Antibiotics
Glycans (in biologics drugs)
Other (small molecules...)
Not Sure
49%
48%
32%
25%
19%
15%
13%
8%
8%
8%
What do the bio/pharma industry analyse using IC?
Suppressed Conductivity
Which detectors are used with IC in the bio/pharma industry?
API, Counterions & Impurities
most analysed
Suppressed Conductivity& UV main detectors employed
