Usage of IC in the bio/pharma industryCurrently Use

Not Sure

Do Not Use

68%

18%

14%

Ultraviolet(UV/Vis)

Conductivity Pulsed Amperometric

Detection (PAD)

Mass Spectrometry

(MS)

Fluorescence Evaporative Light

Scattering Detection

(ELSD)

Charged Aerosol

Detection (CAD)

Inductively Coupled

Plasma-MS (ICP-MS)

High Resolution MS

(HRMS)

Not Sure

38% 38% 33% 27% 22% 11% 9% 8% 8% 6% 11%

How do the bio/pharma industry use compendial monographs?

Use them as a minimum standard and stating point

Follow them word for word

Refer to the methods but don’t follow them

Planning to use them

Do not use them

Not Sure

Use them as a minimum standard and stating point

Follow them word for word

Refer to the methods but don’t follow them

Planning to use them

Do not use them

Not Sure

Are the bio/pharma industry familar with USP General Chapter <1065> ion Chromatography?

Yes No

18%

32%

31%

10%

6%3%

44%

56%

Modernizing pharmacopeial monographs with ICAnions and Cations in

a Drug FormulationAnions and Cations in

a Drug FormulationCurrent Monograph

Scenario

TOTAL # OF TESTS INVOLVED = 5 TOTAL # OF TESTS INVOLVED = 2

With the USP Modernization Initiative

Sodium

Potassium

Magnesium

Chloride

Acetate

Gluconate

Phosphate

Cationic IC

Cationic IC

Cationic IC

Anionic IC

Anionic IC

Anionic IC

Anionic IC

Flame photometry

Flame photometry

Atomic absorption

Titration with silver nitrate

Ion Exclusion Chromatography

Ion Exclusion Chromatography

Spectroscopic Procedure

More on Drug Monographs and Assays Using Ion Chromatographythermofisher.com/PharmaIC

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Application of Ion Chromatography in the Bio/Pharma Industry

In August-September 2017 an online survey was conducted by the Analytical Scientist (a Texere

Publication) on behalf of Thermo Fisher Scientific. The intent was to learn more about the application

of ion chromatography (IC) in the bio/pharmaceutical industry and the level of awareness and

applicability of pharmacopeial monograph modernization. The qualified responses collected in the

survey are the basis for the data shared in this infographic.

APIs/Drug Substances..

Counterions ... of API or Drug Sustance

Impurities/degradants...

Excipients and inactive formulation components

Monosaccharides and sialic acids

Amino acids (in biologics drugs)

Antibiotics

Glycans (in biologics drugs)

Other (small molecules...)

Not Sure

49%

48%

32%

25%

19%

15%

13%

8%

8%

8%

What do the bio/pharma industry analyse using IC?

Suppressed Conductivity

Which detectors are used with IC in the bio/pharma industry?

API, Counterions & Impurities

most analysed

Suppressed Conductivity& UV main detectors employed