Aspirin
A medical miracle
• Source: http://jakeandkims.blogspot.com/2010/07/medicine-highlight-aspirin.html
Index
• Reason for this topic• History• Chemistry of aspirin• Uses• Contra-indications• Side effects• Conclusion• Questions, discussion
Why talk about aspirin?
• Most people come across aspirin
• You can teach an old dog new tricks!
History
• Hippocrates, father of medicine
• Left records of relieving pain
History
• Hippocrates, father of medicine
• 460 – 377 BC
History
• Hippocrates of Kos
History
• Hippocrates of Kos
1829
• Hippo-crates used the willow tree
1829
• It’s in willow tree bark
1829
• It’s salicin does the job!
• But… side effects
1853
• France: Charles Frédéric Gerhardt neutralizes salicin with:– sodium– acetyl chloride
1853
• France: Charles Frédéric Gerhardt neutralizes salicin with:– sodium– acetyl chloride
1900
• Germany: Felix Hoffmann
• Bayer patents the drug
• Its name: aspirin
1900
• Germany: Felix Hoffmann
• Bayer patents the drug
• Its name: aspirin
1900
• Germany: Felix Hoffmann
• Bayer patents the drug
• Its name: aspirin
Chemistry
• salicylic acid
Chemistry
• acetic anhedryde
Chemistry
• aspirin
Uses
• Various pains, e.g.– painful periods– headaches
• Fever
• Stroke
• Heart attack and heart attack prevention
• Arthritis
• Prevention of blood clots
1829Special case
• Stopping a heart attack
• Advice: – Have aspirins ready– Chest pains? Chew one
Side effects
• Abdominal pains, cramps
• Stomach irritation
• Heartburn
• Nausea/vomiting
When not to use
• On women– during pregnancy, especially after 6
months– when breastfeeding
• On children• In case of:
– Salicates allergy– Ulcers– Bleeding disorders
Properties
• Aspirin is absorbed in stomach
Functions
• Decreasing pain
• Decreasing fever
• Preventing blood clots
• Countering strokes and arthitis
More
• http://www.periodicvideos.com/videos/mv_aspirin.htm
• http://en.wikipedia.org/wiki/Aspirin