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Beta Cell Mass in Type 2 DMGepts et al
McClean et al
Westermark et al
Saito et al
Stefan et al
Ann Roy Sci Med Nat 10:1, 1957 Reduced
Diabetes 4:367, 1957 Reduced
Diabetologia 15:417, 1978 Reduced
Tokohu J Exp Med 129:273, 1979 Reduced
Diabetes 31:694, 1982 Reduced
Kloppel et al Surv Synth Path Res 4:110, 1985 Reduced
Clark et al Diabetes Res Clin Prac 4:151, 1988 Reduced
Guiot et al Diabetes 50 (Suppl 1):S188, 2001 Reduced
Sakuraba et al Diabetologia 45:85, 2002 Reduced
Butler et al Diabetes 52:102, 2003 Reduced
Voon et al J Clin Endocrinol Metab 88:2000,2003 Reduced
Rahier et al Diab Obes Metab Suppl 4:32, 2008 Reduced
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35% -cells65% β-cells
52% -cells48% β-cells
P <0.01Adapted from Deng S, et al. Diabetes. 2004;53:624-632.
T2DMControl
In T2DM, β-Cell Mass in Islets is Significantly Reduced
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Beta cell mass is a function of relative rates of apoptosis, replication and neogenesis.
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Butler et alDiabetes 52:102, 2003
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Pathogenesis of Type 2 DiabetesBeta Cell Mass and Function
Normal Abnormal
Insulin Resistance Insulin Resistance
Yes No
Normal Glucose Tolerance Abnormal Glucose Tolerance
Deterioration in Capacity to Secrete Insulin
Glucose-Lipotoxicity Loss of Mass
Type 2 Diabetes
Compensation
+ +
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