beta cell mass in type 2 dm gepts et al mcclean et al westermark et al saito et al stefan et al ann...

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Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367, 1957 Reduced Diabetologia 15:417, 1978 Reduced Tokohu J Exp Med 129:273, 1979 Reduced Diabetes 31:694, 1982 Reduced Kloppel et al Surv Synth Path Res 4:110, 1985 Reduced Clark et al Diabetes Res Clin Prac 4:151, 1988Reduced Guiot et al Diabetes 50 (Suppl 1):S188, 2001 Reduced Sakuraba et al Diabetologia 45:85, 2002 Reduced Butler et al Diabetes 52:102, 2003 Reduced Voon et al J Clin Endocrinol Metab 88:2000,2003 Reduced Rahier et al Diab Obes Metab Suppl 4:32, 2008 Reduced

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Page 1: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Beta Cell Mass in Type 2 DMGepts et al

McClean et al

Westermark et al

Saito et al

Stefan et al

Ann Roy Sci Med Nat 10:1, 1957 Reduced

Diabetes 4:367, 1957 Reduced

Diabetologia 15:417, 1978 Reduced

Tokohu J Exp Med 129:273, 1979 Reduced

Diabetes 31:694, 1982 Reduced

Kloppel et al Surv Synth Path Res 4:110, 1985 Reduced

Clark et al Diabetes Res Clin Prac 4:151, 1988 Reduced

Guiot et al Diabetes 50 (Suppl 1):S188, 2001 Reduced

Sakuraba et al Diabetologia 45:85, 2002 Reduced

Butler et al Diabetes 52:102, 2003 Reduced

Voon et al J Clin Endocrinol Metab 88:2000,2003 Reduced

Rahier et al Diab Obes Metab Suppl 4:32, 2008 Reduced

Page 2: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Page 3: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Page 4: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

35% -cells65% β-cells

52% -cells48% β-cells

P <0.01Adapted from Deng S, et al. Diabetes. 2004;53:624-632.

T2DMControl

In T2DM, β-Cell Mass in Islets is Significantly Reduced

Page 5: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Beta cell mass is a function of relative rates of apoptosis, replication and neogenesis.

Page 6: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Butler et alDiabetes 52:102, 2003

Page 7: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Page 8: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Pathogenesis of Type 2 DiabetesBeta Cell Mass and Function

Normal Abnormal

Insulin Resistance Insulin Resistance

Yes No

Normal Glucose Tolerance Abnormal Glucose Tolerance

Deterioration in Capacity to Secrete Insulin

Glucose-Lipotoxicity Loss of Mass

Type 2 Diabetes

Compensation

+ +

Page 9: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Page 10: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Page 11: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

Page 12: Beta Cell Mass in Type 2 DM Gepts et al McClean et al Westermark et al Saito et al Stefan et al Ann Roy Sci Med Nat 10:1, 1957 Reduced Diabetes 4:367,

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